首页 > 最新文献

International Journal of Drug Development and Research最新文献

英文 中文
Abordagens terapeuticas na osteomielite crônica bacteriana: uma revisão integrativa de literatura 慢性细菌性骨髓炎的治疗方法:综合文献综述
Pub Date : 2023-07-28 DOI: 10.37118/ijdr.26933.07.2023
Objetivo: Revisar de forma integrativaas principais formas de tratamento e diagnóstico de acordo com as bactérias mais encontradas nas infecções da Osteomielite crônica. Métodos: Foram utilizadas as bases de dados BVS-Lilacs, PubMed, SciElo e Cochrane Library através dos descritores “osteomyelitis”, “chronic” e “treatment” entre o período de 2016 a 2021. Resultados e Discussão: 13 artigos foram selecionados, a partir dos critérios de inclusão, reunindo informações acerca da Osteomielite Crônica. A Osteomielite Crônica ocorre geralmente nas infecções agudas tratadas de forma incorreta ou após procedimento cirúrgico. Os patógenos podem fazer parte da microbióta hospitalar, como a Pseudomonas aeruginosa eStaphylococcus aureus ou podem ser de origem polibacteriana. Os três principais locais de infecção são fêmur, tibiofibular e articulação do quadril e tratamento costuma ser cirúrgico associado a antibióticos locais e orais. A reincidência geralmente ocorre pelas bactérias MRSA (Staphilococcus aureus Resistentes a Metilcilina) e leva a substituição de antibióticos β-lactâmicos (penicillinas, cefalosporinas, carbapenem e subfamílias monobactam) pelos de 5ª geração como a daptomicina associada a rifampicina, vancomicina, fluoroquinolonas ou sulfametoxazol-trimetoprima (TMP-SMX). Conclusão: O presente estudo revelou a importância de revisar os mecanismos terapêuticos sobre a osteomielite aguda, visto que é considerada uma doença com elevado risco de reincidência e evoluir para o quadro crônico através de contaminações por microorganismos multirresistentes ao esquema terapêutico das drogas usuais.
摘要目的:根据慢性骨髓炎感染中最常见的细菌,综合回顾主要的治疗和诊断方法。方法:我们使用BVS-Lilacs、PubMed、SciElo和Cochrane Library数据库,描述符为“骨髓炎”、“慢性”和“治疗”,时间为2016 - 2021年。结果与讨论:从纳入标准中选择13篇文章,收集有关慢性骨髓炎的信息。慢性骨髓炎通常发生在治疗不当的急性感染或手术后。病原体可以是医院微生物群的一部分,如铜绿假单胞菌金黄色葡萄球菌,也可以是多细菌来源。感染的三个主要部位是股骨、胫骨和髋关节,治疗通常是手术结合局部和口服抗生素。通常在复发耐药细菌耐甲氧西林金黄色葡萄球菌(Staphilococcus球菌Metilcilina)和带替代抗生素β-lactâmicos (penicillinas,头孢菌素、附着和亚科5ª代monobactam)为达与利福平,万古霉素,氟喹诺酮类药物或磺胺甲恶唑-trimetoprima (TMP -SMX)。结论:本研究揭示了回顾急性骨髓炎治疗机制的重要性,因为它被认为是一种复发风险高的疾病,并通过对常用药物治疗方案的多重耐药微生物污染发展为慢性疾病。
{"title":"Abordagens terapeuticas na osteomielite crônica bacteriana: uma revisão integrativa de literatura","authors":"","doi":"10.37118/ijdr.26933.07.2023","DOIUrl":"https://doi.org/10.37118/ijdr.26933.07.2023","url":null,"abstract":"Objetivo: Revisar de forma integrativaas principais formas de tratamento e diagnóstico de acordo com as bactérias mais encontradas nas infecções da Osteomielite crônica. Métodos: Foram utilizadas as bases de dados BVS-Lilacs, PubMed, SciElo e Cochrane Library através dos descritores “osteomyelitis”, “chronic” e “treatment” entre o período de 2016 a 2021. Resultados e Discussão: 13 artigos foram selecionados, a partir dos critérios de inclusão, reunindo informações acerca da Osteomielite Crônica. A Osteomielite Crônica ocorre geralmente nas infecções agudas tratadas de forma incorreta ou após procedimento cirúrgico. Os patógenos podem fazer parte da microbióta hospitalar, como a Pseudomonas aeruginosa eStaphylococcus aureus ou podem ser de origem polibacteriana. Os três principais locais de infecção são fêmur, tibiofibular e articulação do quadril e tratamento costuma ser cirúrgico associado a antibióticos locais e orais. A reincidência geralmente ocorre pelas bactérias MRSA (Staphilococcus aureus Resistentes a Metilcilina) e leva a substituição de antibióticos β-lactâmicos (penicillinas, cefalosporinas, carbapenem e subfamílias monobactam) pelos de 5ª geração como a daptomicina associada a rifampicina, vancomicina, fluoroquinolonas ou sulfametoxazol-trimetoprima (TMP-SMX). Conclusão: O presente estudo revelou a importância de revisar os mecanismos terapêuticos sobre a osteomielite aguda, visto que é considerada uma doença com elevado risco de reincidência e evoluir para o quadro crônico através de contaminações por microorganismos multirresistentes ao esquema terapêutico das drogas usuais.","PeriodicalId":13916,"journal":{"name":"International Journal of Drug Development and Research","volume":"16 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-07-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88055208","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Inbound marketing and e-commerce on user experience in Algeria 阿尔及利亚用户体验的入站营销和电子商务
Pub Date : 2023-07-28 DOI: 10.37118/ijdr.26963.07.2023
In today's digital age, businesses have undergone a profound transformation with the advent of digital technologies and marketing strategies. Digital transformation encompasses the integration of digital tools and technologies across all areas of a business, leading to fundamental changes in its operations, value delivery, and customer engagement. Simultaneously, digital marketing involves utilizing online platforms, including websites, social media, and online advertising, to promote products or services and expand the reach to a broader audience. The synergy between digital transformation and digital marketing enables businesses to adapt to the ever-evolving digital landscape, enhance customer experiences, streamline processes, and gain a competitive edge in a digitally interconnected world. This article aims to explore the significance of inbound marketing and e-commerce in shaping the user experience in the digital age. Through quantitative research involving a questionnaire, the study identifies key elements of inbound marketing, such as personalized content, targeted advertising, and user segmentation. These elements have a substantial impact on user experience satisfaction, engagement, and loyalty within the e-commerce context, particularly among Algerian consumers.
在当今的数字时代,随着数字技术和营销策略的出现,企业经历了深刻的变革。数字化转型包括跨业务所有领域的数字化工具和技术的集成,导致其运营、价值交付和客户参与的根本变化。同时,数字营销涉及到利用在线平台,包括网站、社交媒体和在线广告,来推广产品或服务,并扩大到更广泛的受众。数字化转型和数字化营销之间的协同作用使企业能够适应不断发展的数字环境,增强客户体验,简化流程,并在数字化互联的世界中获得竞争优势。本文旨在探讨入站营销和电子商务在数字时代塑造用户体验方面的意义。通过问卷调查的定量研究,该研究确定了入站营销的关键要素,如个性化内容、目标广告和用户细分。这些因素对电子商务背景下的用户体验满意度、参与度和忠诚度有重大影响,尤其是在阿尔及利亚消费者中。
{"title":"Inbound marketing and e-commerce on user experience in Algeria","authors":"","doi":"10.37118/ijdr.26963.07.2023","DOIUrl":"https://doi.org/10.37118/ijdr.26963.07.2023","url":null,"abstract":"In today's digital age, businesses have undergone a profound transformation with the advent of digital technologies and marketing strategies. Digital transformation encompasses the integration of digital tools and technologies across all areas of a business, leading to fundamental changes in its operations, value delivery, and customer engagement. Simultaneously, digital marketing involves utilizing online platforms, including websites, social media, and online advertising, to promote products or services and expand the reach to a broader audience. The synergy between digital transformation and digital marketing enables businesses to adapt to the ever-evolving digital landscape, enhance customer experiences, streamline processes, and gain a competitive edge in a digitally interconnected world. This article aims to explore the significance of inbound marketing and e-commerce in shaping the user experience in the digital age. Through quantitative research involving a questionnaire, the study identifies key elements of inbound marketing, such as personalized content, targeted advertising, and user segmentation. These elements have a substantial impact on user experience satisfaction, engagement, and loyalty within the e-commerce context, particularly among Algerian consumers.","PeriodicalId":13916,"journal":{"name":"International Journal of Drug Development and Research","volume":"107 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-07-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76666629","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Buddha and nature as depicted in Aśvaghoṣa’s buddhacarita 如Aśvaghoṣa的《佛缘》所描绘的佛与自然
Pub Date : 2023-07-28 DOI: 10.37118/ijdr.26906.07.2023
This paper emphasizes the deep interdependence of nature and the Buddha as depicted in Buddhacarita of Aśvaghoṣa Bodhisattva. The text contends that the Buddha was inextricably linked with the natural world throughout his life. Nature is the Buddha's ally in the path to enlightenment, cultivating a deep regard for nature's extraordinary beauty and diversity. The accounts of the Buddha's life in Buddhacarita are difficult to divide between stories, facts, and myths. Many plants, flowers, animals, and trees are linked to Buddha's life story. Animals affected the Buddha's yearning for Nibbāna; observing the suffering of both mankind and animals motivated him to seek enlightenment. Furthermore, the Buddha's relationship with natural events is portrayed as one of the Buddha's vast and amazing traits. This paper employs the literary analysis method on three well-known English translations. The first is The Buddhacarita, or Acts of the Buddha, which E.H. Johnson translated from Sanskrit and augmented with the Tibetan version. The second is E.B. Cowell's translation from Sanskrit titled The Buddhacarita of Aśvaghoṣa. The last is Samuel Beal's translation from Chinese of The Fo-Sho-Hing-Tsan-King. According to the findings, Buddha's life is a remarkable example of the close relationship between humans and nature. It serves as a reminder that human and nonhuman ecosystems are intrinsically linked and intertwined.
本文强调了《Aśvaghoṣa菩萨》中所描绘的自然与佛的深层相互依存关系。文中认为,佛陀一生都与自然世界有着千丝万缕的联系。大自然是佛陀开悟之路的盟友,培养了对大自然非凡之美和多样性的深切关注。佛陀在《释迦牟尼》中的生平很难区分为故事、事实和神话。许多植物、花卉、动物和树木都与佛陀的生活故事有关。动物影响了佛陀对Nibbāna的向往;观察人类和动物的痛苦促使他寻求启蒙。此外,佛陀与自然事件的关系被描绘成佛陀巨大而惊人的特征之一。本文采用文学分析法对三部著名英译本进行分析。第一部是《佛行经》,由E.H.约翰逊从梵文翻译而来,并增补了藏文版本。第二本是e·b·考威尔从梵文翻译的《佛教》Aśvaghoṣa。最后一篇是塞缪尔·比尔翻译的《法王》。根据研究结果,佛陀的一生是人与自然密切关系的一个杰出例子。它提醒我们,人类和非人类生态系统是内在联系和交织在一起的。
{"title":"Buddha and nature as depicted in Aśvaghoṣa’s buddhacarita","authors":"","doi":"10.37118/ijdr.26906.07.2023","DOIUrl":"https://doi.org/10.37118/ijdr.26906.07.2023","url":null,"abstract":"This paper emphasizes the deep interdependence of nature and the Buddha as depicted in Buddhacarita of Aśvaghoṣa Bodhisattva. The text contends that the Buddha was inextricably linked with the natural world throughout his life. Nature is the Buddha's ally in the path to enlightenment, cultivating a deep regard for nature's extraordinary beauty and diversity. The accounts of the Buddha's life in Buddhacarita are difficult to divide between stories, facts, and myths. Many plants, flowers, animals, and trees are linked to Buddha's life story. Animals affected the Buddha's yearning for Nibbāna; observing the suffering of both mankind and animals motivated him to seek enlightenment. Furthermore, the Buddha's relationship with natural events is portrayed as one of the Buddha's vast and amazing traits. This paper employs the literary analysis method on three well-known English translations. The first is The Buddhacarita, or Acts of the Buddha, which E.H. Johnson translated from Sanskrit and augmented with the Tibetan version. The second is E.B. Cowell's translation from Sanskrit titled The Buddhacarita of Aśvaghoṣa. The last is Samuel Beal's translation from Chinese of The Fo-Sho-Hing-Tsan-King. According to the findings, Buddha's life is a remarkable example of the close relationship between humans and nature. It serves as a reminder that human and nonhuman ecosystems are intrinsically linked and intertwined.","PeriodicalId":13916,"journal":{"name":"International Journal of Drug Development and Research","volume":"11 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-07-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89047000","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Exploring the evolutionary relationships and impact of metacaspase proteins in harmful algal blooms in the uae waters 探索阿联酋水域有害藻华中metacaspase蛋白的进化关系和影响
Pub Date : 2023-07-28 DOI: 10.37118/ijdr.26971.07.2023
Harmful algal blooms (HABs) pose significant threats to aquatic ecosystems, human health, and coastal economies worldwide. The causative agents of HABs are primarily dinoflagellates Marglefidiniumpolykrikoides and Prorocentrum minimum), and diatoms (Chaetocerostenuissimus, Fragilaria radians, Phaeodactylumtricornutum, and Skeletonemamarinoi), which produce various toxins that exacerbate the harmful effects. Metacaspase, a toxin-producing protein, has emerged as a critical component in the pathogenesis of HABs. This study aims to investigate the evolutionary relationships among diatoms and dinoflagellates based on the metacaspase protein. The analysis based on sequence clustering, indicates that the dinoflagellates anddiatoms share common ancestors where Marglefidiniumpolykrikoides and Prorocentrum minimum are evolutionarily closer to diatom Skeletonemamarinoi. This study prepares the base to further explore their involvement in HABs, elucidate the production of metacaspase by specific diatom and dinoflagellate species, and investigate the role of metacaspase in the toxicity of HABs.
有害藻华(HABs)对全球水生生态系统、人类健康和沿海经济构成重大威胁。有害藻华的病原体主要是鞭毛藻(marlefidiniumpolykrikoides和proorocentrum minimum)和硅藻(chaetocerosteruissimus、Fragilaria radians、Phaeodactylumtricornutum和onemamarinoi),它们产生各种毒素,加剧有害影响。Metacaspase是一种产生毒素的蛋白质,已成为HABs发病机制的关键组成部分。本研究旨在探讨硅藻和鞭毛藻之间基于metacaspase蛋白的进化关系。序列聚类分析表明,鞭毛藻和硅藻具有共同的祖先,其中Marglefidiniumpolykrikoides和proocentrum minimum在进化上更接近于硅藻骷髅藻。本研究为进一步探讨它们在赤潮中的作用、阐明特定硅藻和鞭毛藻产生metacaspase以及metacaspase在赤潮毒性中的作用奠定了基础。
{"title":"Exploring the evolutionary relationships and impact of metacaspase proteins in harmful algal blooms in the uae waters","authors":"","doi":"10.37118/ijdr.26971.07.2023","DOIUrl":"https://doi.org/10.37118/ijdr.26971.07.2023","url":null,"abstract":"Harmful algal blooms (HABs) pose significant threats to aquatic ecosystems, human health, and coastal economies worldwide. The causative agents of HABs are primarily dinoflagellates Marglefidiniumpolykrikoides and Prorocentrum minimum), and diatoms (Chaetocerostenuissimus, Fragilaria radians, Phaeodactylumtricornutum, and Skeletonemamarinoi), which produce various toxins that exacerbate the harmful effects. Metacaspase, a toxin-producing protein, has emerged as a critical component in the pathogenesis of HABs. This study aims to investigate the evolutionary relationships among diatoms and dinoflagellates based on the metacaspase protein. The analysis based on sequence clustering, indicates that the dinoflagellates anddiatoms share common ancestors where Marglefidiniumpolykrikoides and Prorocentrum minimum are evolutionarily closer to diatom Skeletonemamarinoi. This study prepares the base to further explore their involvement in HABs, elucidate the production of metacaspase by specific diatom and dinoflagellate species, and investigate the role of metacaspase in the toxicity of HABs.","PeriodicalId":13916,"journal":{"name":"International Journal of Drug Development and Research","volume":"69 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-07-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88530836","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Improving hots literacy using the pjbl model with learner worksheets-based guided inquiry on reaction rate materials 使用pjbl模型和基于学习者工作表的对反应速率材料的引导探究来提高学生的读写能力
Pub Date : 2023-07-28 DOI: 10.37118/ijdr.26961.07.2023
The logical influence of the demands of teacher professionalism in the presentation of chemistry learning is the teacher's ability to create the right learning strategy in accordance with the problems faced in the world of education. One of the things that can be done in solving the problem in question is to transfer the old learning method with the new one. This study aims to determine the improvement of HOTS literacy by integrating the PjBL model with Guided inquiry students worksheed on the Reaction Rate material in class XI SMA and to describe the most developed aspects of HOTS literacy. This research is a Quantitative Descriptive research using an experimental method with a One-Group Pretest-Posttest Design design. The results showed that students' HOTS literacy ability increased through learning with the PjBL model with Crossword media, this was proven through a t-test that obtained a value tcount> ttable (7.152 > 2,03452) with an N-gain value of 0.7079 (70.79%).
教师专业化要求对化学学习呈现的逻辑影响是教师根据教育界面临的问题制定正确学习策略的能力。要解决这个问题,可以做的事情之一就是把旧的学习方法和新的学习方法结合起来。本研究是一项定量描述性研究,采用一组前测后测设计的实验方法。结果表明,通过使用填字游戏媒介的PjBL模型学习,学生的HOTS读写能力得到了提高,通过t检验得到值tcount>表(7.152 > 2,03452),n增益值为0.7079(70.79%)。
{"title":"Improving hots literacy using the pjbl model with learner worksheets-based guided inquiry on reaction rate materials","authors":"","doi":"10.37118/ijdr.26961.07.2023","DOIUrl":"https://doi.org/10.37118/ijdr.26961.07.2023","url":null,"abstract":"The logical influence of the demands of teacher professionalism in the presentation of chemistry learning is the teacher's ability to create the right learning strategy in accordance with the problems faced in the world of education. One of the things that can be done in solving the problem in question is to transfer the old learning method with the new one. This study aims to determine the improvement of HOTS literacy by integrating the PjBL model with Guided inquiry students worksheed on the Reaction Rate material in class XI SMA and to describe the most developed aspects of HOTS literacy. This research is a Quantitative Descriptive research using an experimental method with a One-Group Pretest-Posttest Design design. The results showed that students' HOTS literacy ability increased through learning with the PjBL model with Crossword media, this was proven through a t-test that obtained a value tcount> ttable (7.152 > 2,03452) with an N-gain value of 0.7079 (70.79%).","PeriodicalId":13916,"journal":{"name":"International Journal of Drug Development and Research","volume":"29 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-07-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87265500","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The effect of body weight on peak expiratory flow rate (pefr) among the adolescent rural school children, an observational study 体重对农村学龄青少年呼气流量峰值(pefr)的影响:一项观察性研究
Pub Date : 2023-07-28 DOI: 10.37118/ijdr.26872.07.2023
Background: The increasing prevalence of childhood obesity in developing countries is a growing public health concern. Obesity has been linked to pulmonary dysfunction, including reduced peak expiratory flow rate (PEFR). This study aimed to investigate the effect of body weight on PEFR among rural adolescent school children. Methods: A cross-sectional observational study was conducted in schools located in and around Nagamangala Taluk, with a study duration of 18 months. The sample size was determined using a formula based on the prevalence of obesity in school-going children. Anthropometric measurements, including height, weight, waist circumference (WC), and waist-to-height ratio (WHtR), were recorded. PEFR was measured using a peak flow meter. Statistical analysis, including correlation coefficient, t-test, and linear regression analysis, was performed using SPSS version 26. Results: The study included 573 rural adolescent school children, with a majority aged between 13 and 15 years and a higher proportion of female participants. The prevalence of overweight based on WHtR was 29.7%. There was no significant difference in mean age between overweight and normal WHtR groups. However, a higher prevalence of overweight was observed among boys compared to girls. Higher consumption of sweets, soft drinks, and fast food was significantly associated with overweight, while a higher frequency of exercise showed an inverse association. Longer duration of TV viewing was also associated with overweight. Overweight children had a significantly higher mean BMI and lower mean PEFR compared to children with a normal WHtR. There was a significant inverse correlation between PEFR and both BMI and WHtR. Conclusion: The present study observed a significant inverse correlation between PEFR and both BMI and WHtR. The study findings support the negative impact of excess body weight on lung function, as evidenced by reduced PEFR among overweight rural adolescent school children. The results emphasize the need for interventions to address childhood obesity and promote healthy lifestyle behaviors. Awareness among healthcare professionals, parents, and educators is crucial for early detection and management of pulmonary dysfunction associated with excess body weight in children.
背景:儿童肥胖症在发展中国家日益普遍,这是一个日益令人关注的公共卫生问题。肥胖与肺功能障碍有关,包括呼气流量峰值(PEFR)降低。本研究旨在探讨体重对农村青少年学龄儿童PEFR的影响。方法:在Nagamangala Taluk及其周围的学校进行了一项横断面观察研究,研究时间为18个月。样本量是根据学龄儿童肥胖的流行程度来确定的。记录人体测量数据,包括身高、体重、腰围(WC)和腰高比(WHtR)。PEFR采用峰值流量计测量。统计分析采用SPSS 26进行,包括相关系数、t检验和线性回归分析。结果:研究对象为573名农村青少年学童,年龄在13 - 15岁之间,女性比例较高。基于WHtR的超重患病率为29.7%。超重组和正常WHtR组的平均年龄无显著差异。然而,与女孩相比,男孩中超重的患病率更高。多吃甜食、软饮料和快餐与超重显著相关,而高频率的运动则呈反比关系。长时间看电视也与超重有关。与WHtR正常的儿童相比,超重儿童的平均BMI明显较高,平均PEFR明显较低。PEFR与BMI、WHtR均呈显著负相关。结论:本研究发现PEFR与BMI和WHtR均呈显著负相关。研究结果支持超重对肺功能的负面影响,如超重农村青少年学龄儿童PEFR降低。研究结果强调需要采取干预措施来解决儿童肥胖问题,促进健康的生活方式行为。医疗保健专业人员、家长和教育工作者的意识对于早期发现和管理与儿童超重相关的肺功能障碍至关重要。
{"title":"The effect of body weight on peak expiratory flow rate (pefr) among the adolescent rural school children, an observational study","authors":"","doi":"10.37118/ijdr.26872.07.2023","DOIUrl":"https://doi.org/10.37118/ijdr.26872.07.2023","url":null,"abstract":"Background: The increasing prevalence of childhood obesity in developing countries is a growing public health concern. Obesity has been linked to pulmonary dysfunction, including reduced peak expiratory flow rate (PEFR). This study aimed to investigate the effect of body weight on PEFR among rural adolescent school children. Methods: A cross-sectional observational study was conducted in schools located in and around Nagamangala Taluk, with a study duration of 18 months. The sample size was determined using a formula based on the prevalence of obesity in school-going children. Anthropometric measurements, including height, weight, waist circumference (WC), and waist-to-height ratio (WHtR), were recorded. PEFR was measured using a peak flow meter. Statistical analysis, including correlation coefficient, t-test, and linear regression analysis, was performed using SPSS version 26. Results: The study included 573 rural adolescent school children, with a majority aged between 13 and 15 years and a higher proportion of female participants. The prevalence of overweight based on WHtR was 29.7%. There was no significant difference in mean age between overweight and normal WHtR groups. However, a higher prevalence of overweight was observed among boys compared to girls. Higher consumption of sweets, soft drinks, and fast food was significantly associated with overweight, while a higher frequency of exercise showed an inverse association. Longer duration of TV viewing was also associated with overweight. Overweight children had a significantly higher mean BMI and lower mean PEFR compared to children with a normal WHtR. There was a significant inverse correlation between PEFR and both BMI and WHtR. Conclusion: The present study observed a significant inverse correlation between PEFR and both BMI and WHtR. The study findings support the negative impact of excess body weight on lung function, as evidenced by reduced PEFR among overweight rural adolescent school children. The results emphasize the need for interventions to address childhood obesity and promote healthy lifestyle behaviors. Awareness among healthcare professionals, parents, and educators is crucial for early detection and management of pulmonary dysfunction associated with excess body weight in children.","PeriodicalId":13916,"journal":{"name":"International Journal of Drug Development and Research","volume":"s3-29 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-07-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90819250","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The correspondence between emptiness, dependent origination, and Nirvāna in early Buddhist Literature 早期佛教文献中空性、缘起与Nirvāna的对应关系
Pub Date : 2023-07-28 DOI: 10.37118/ijdr.26960.07.2023
The logical influence of the demands of teacher professionalism in the presentation of chemistry learning is the teacher's ability to create the right learning strategy in accordance with the problems faced in the world of education. One of the things that can be done in solving the problem in question is to transfer the old learning method with the new one. This study aims to determine the improvement of HOTS literacy by integrating the PjBL model with Guided inquiry students worksheed on the Reaction Rate material in class XI SMA and to describe the most developed aspects of HOTS literacy. This research is a Quantitative Descriptive research using an experimental method with a One-Group Pretest-Posttest Design design. The results showed that students' HOTS literacy ability increased through learning with the PjBL model with Crossword media, this was proven through a t-test that obtained a value tcount> ttable (7.152 > 2,03452) with an N-gain value of 0.7079 (70.79%).
教师专业化要求对化学学习呈现的逻辑影响是教师根据教育界面临的问题制定正确学习策略的能力。要解决这个问题,可以做的事情之一就是把旧的学习方法和新的学习方法结合起来。本研究是一项定量描述性研究,采用一组前测后测设计的实验方法。结果表明,通过使用填字游戏媒介的PjBL模型学习,学生的HOTS读写能力得到了提高,通过t检验得到值tcount>表(7.152 > 2,03452),n增益值为0.7079(70.79%)。
{"title":"The correspondence between emptiness, dependent origination, and Nirvāna in early Buddhist Literature","authors":"","doi":"10.37118/ijdr.26960.07.2023","DOIUrl":"https://doi.org/10.37118/ijdr.26960.07.2023","url":null,"abstract":"The logical influence of the demands of teacher professionalism in the presentation of chemistry learning is the teacher's ability to create the right learning strategy in accordance with the problems faced in the world of education. One of the things that can be done in solving the problem in question is to transfer the old learning method with the new one. This study aims to determine the improvement of HOTS literacy by integrating the PjBL model with Guided inquiry students worksheed on the Reaction Rate material in class XI SMA and to describe the most developed aspects of HOTS literacy. This research is a Quantitative Descriptive research using an experimental method with a One-Group Pretest-Posttest Design design. The results showed that students' HOTS literacy ability increased through learning with the PjBL model with Crossword media, this was proven through a t-test that obtained a value tcount> ttable (7.152 > 2,03452) with an N-gain value of 0.7079 (70.79%).","PeriodicalId":13916,"journal":{"name":"International Journal of Drug Development and Research","volume":"56 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-07-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74035247","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Contribution des filets sociaux à l'amélioration des conditions de vie des ménages dans la province du zondoma 社会网络对改善宗多马省家庭生活条件的贡献
Pub Date : 2023-07-28 DOI: 10.37118/ijdr.26921.07.2023
The aim of this research was to measure the contribution of the social safety net project to the improvement of household living conditions and the development of early childhood in the province of Zondoma from 2015 to 2019. The methodological approach used is is based on field surveys with a dynamic and interactive approach that involved beneficiaries, resource persons and project managers. The results show that the Social Safety Nets project has positive effects on the economic and social level within the beneficiary community and more particularly on the beneficiary families, despite some difficulties observed in its implementation. For better consideration of early childhood in Burkinabe households with a view to breaking the intergenerational transmission of poverty, advocacy should be developed to increase funding for social protection, in order to reach all poor and vulnerable households ; set up a unified social register highlighting poor and vulnerables households with young children; coordinate the different approaches to social protection; strengthen support for beneficiaries despite degraded security conditions; and sustain the achievements through the provision of community relays after the closure of the project.
本研究的目的是衡量2015年至2019年社会安全网项目对Zondoma省家庭生活条件改善和幼儿发展的贡献。所使用的方法是以实地调查为基础的,采用有受益者、资源人员和项目管理人员参与的动态和相互作用的方法。结果表明,社会安全网项目对受益社区的经济和社会层面产生了积极影响,尤其是对受益家庭,尽管在实施过程中发现了一些困难。为了更好地考虑到布基纳法索家庭中的幼儿,以便打破贫穷的代际传递,应开展宣传活动,增加社会保护的资金,以便惠及所有贫穷和脆弱的家庭;建立一个统一的社会登记册,突出显示有年幼儿童的贫困和弱势家庭;协调不同的社会保护办法;加强对受益人的支持,尽管安全状况恶化;并在项目结束后通过提供社区接力赛来维持这些成果。
{"title":"Contribution des filets sociaux à l'amélioration des conditions de vie des ménages dans la province du zondoma","authors":"","doi":"10.37118/ijdr.26921.07.2023","DOIUrl":"https://doi.org/10.37118/ijdr.26921.07.2023","url":null,"abstract":"The aim of this research was to measure the contribution of the social safety net project to the improvement of household living conditions and the development of early childhood in the province of Zondoma from 2015 to 2019. The methodological approach used is is based on field surveys with a dynamic and interactive approach that involved beneficiaries, resource persons and project managers. The results show that the Social Safety Nets project has positive effects on the economic and social level within the beneficiary community and more particularly on the beneficiary families, despite some difficulties observed in its implementation. For better consideration of early childhood in Burkinabe households with a view to breaking the intergenerational transmission of poverty, advocacy should be developed to increase funding for social protection, in order to reach all poor and vulnerable households ; set up a unified social register highlighting poor and vulnerables households with young children; coordinate the different approaches to social protection; strengthen support for beneficiaries despite degraded security conditions; and sustain the achievements through the provision of community relays after the closure of the project.","PeriodicalId":13916,"journal":{"name":"International Journal of Drug Development and Research","volume":"15 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-07-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86934801","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A licensing plan for coupling nuclear–renewable hybrid energy systems 核-可再生混合能源系统耦合许可计划
Pub Date : 2023-07-28 DOI: 10.37118/ijdr.26914.07.2023
South Africa committed to reducing greenhouse gas emissions by 34% below "Business As Usual" levels by 2020 and 42% by 2025 at the Copenhagen climate change conference. However, global energy demand was projected to rise due to population and industrial growth, with energy usage expected to increase by 13% through 2040. In South Africa, a steady increase in electricity demand prompted the government to implement a new growth path (NGP), which prioritized job creation in all economic policies, including energy. To address the growing energy demand, an alternative energy source for combined heat and power was necessary, particularly for synthetic fuel production. The coupling of a high temperature reactor (HTR) with a chemical process plant could improve carbon and thermal efficiency, as seen in international organizations like the ARCHER (Advanced High-Temperature Reactors for Cogeneration of Heat and Electricity R&D) project. HTRs are still in their conceptual stages andaresuitable candidate forcouplingto an energy-intensiveindustrythat require process heat with sufficiently hightemperatures,with potential uses for NRHES (Nuclear-Renewable Hybrid Energy Systems). The South African team aimed to model the SASOL process, assess its financial viability, and develop a licensing plan.
在哥本哈根气候变化会议上,南非承诺到2020年将温室气体排放量在“一切照旧”水平基础上减少34%,到2025年减少42%。然而,由于人口和工业的增长,全球能源需求预计将上升,到2040年,能源使用量预计将增长13%。在南非,电力需求的稳步增长促使政府实施新的增长路径(NGP),在包括能源在内的所有经济政策中优先考虑创造就业机会。为了满足日益增长的能源需求,需要一种热电联产的替代能源,特别是用于合成燃料生产。高温反应堆(HTR)与化学处理厂的耦合可以提高碳和热效率,正如ARCHER(用于热电联产的先进高温反应堆研发)项目等国际组织所看到的那样。htr仍处于概念阶段,是能源密集型工业的合适候选者,需要足够高温度的过程热量,具有NRHES(核可再生混合能源系统)的潜在用途。南非团队的目标是模拟SASOL过程,评估其财务可行性,并制定许可计划。
{"title":"A licensing plan for coupling nuclear–renewable hybrid energy systems","authors":"","doi":"10.37118/ijdr.26914.07.2023","DOIUrl":"https://doi.org/10.37118/ijdr.26914.07.2023","url":null,"abstract":"South Africa committed to reducing greenhouse gas emissions by 34% below \"Business As Usual\" levels by 2020 and 42% by 2025 at the Copenhagen climate change conference. However, global energy demand was projected to rise due to population and industrial growth, with energy usage expected to increase by 13% through 2040. In South Africa, a steady increase in electricity demand prompted the government to implement a new growth path (NGP), which prioritized job creation in all economic policies, including energy. To address the growing energy demand, an alternative energy source for combined heat and power was necessary, particularly for synthetic fuel production. The coupling of a high temperature reactor (HTR) with a chemical process plant could improve carbon and thermal efficiency, as seen in international organizations like the ARCHER (Advanced High-Temperature Reactors for Cogeneration of Heat and Electricity R&D) project. HTRs are still in their conceptual stages andaresuitable candidate forcouplingto an energy-intensiveindustrythat require process heat with sufficiently hightemperatures,with potential uses for NRHES (Nuclear-Renewable Hybrid Energy Systems). The South African team aimed to model the SASOL process, assess its financial viability, and develop a licensing plan.","PeriodicalId":13916,"journal":{"name":"International Journal of Drug Development and Research","volume":"38 4 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-07-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90214186","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Quality of life and coping strategies in the Covid-19 pandemic: Comparison analysis between middle-aged and eldery people 新冠肺炎大流行中老年人的生活质量与应对策略比较分析
Pub Date : 2023-07-28 DOI: 10.37118/ijdr.26908.07.2023
The emergence of the coronavirus disease (COVID-19) has triggered a global public health crisis and posed an unprecedented threat to mental health worldwide. The aim of this study was to compare quality of life variables and coping strategies during the COVID-19 pandemic between two different age groups: middle-aged people and elderly people. Descriptive and comparative studies were carried out. The study has a quantitative, correlational and cross-sectional design. The sample was for convenience and not probabilistic. 311 people aged over 40 years were interviewed. The following evaluation instruments were used: socio-demographic data, EUROHIS- QOL and the Coping Strategies Inventory. For the comparative study of means, the Mann-Whitney U test was used, with a significance level ≤. 0.05. For the statistical study, IBM-SPSS, v. 28.0. A statistically significant relationship (p<0.001) was identified with respect to the variable satisfaction with personal relationships during the pandemic, being higher among the group of elderly people. Coping strategies were more used by the middle-aged group (p=0.050). Coping strategies: thought that the situation happened because of others (p=0.031), complained or vented to someone (p<0.001), showed hostility (p=0.018), drank and ate excessively to compensate or to forget what was happening (p<0.001), shouting and swearing (p<0.001) were more used by middle-aged people. The strategy trusted in God or in some higher being or force was more used by elderly participants (p=0.012). The expression of negative emotions was more used by the middle-aged group (p<0.001) and the inhibition of emotions as well (p=0.002). The results highlight the resilience of older adults during the COVID-19 pandemic and provide additional insight into the influence of pandemic-related stressors on age-related psychosocial functioning.
新型冠状病毒病(COVID-19)的出现引发了全球公共卫生危机,对全球精神卫生构成了前所未有的威胁。本研究的目的是比较两个不同年龄组:中年人和老年人在COVID-19大流行期间的生活质量变量和应对策略。进行了描述性和比较性研究。本研究采用定量、相关和横断面设计。这个样本是为了方便而不是概率。调查对象为311名40岁以上的老年人。使用了以下评估工具:社会人口统计数据、EUROHIS- QOL和应对策略量表。均值比较研究采用Mann-Whitney U检验,显著性水平≤。0.05. 统计研究采用IBM-SPSS, v. 28.0。在大流行期间,对个人关系的变量满意度存在统计学显著关系(p<0.001),在老年人群体中更高。中年组使用应对策略较多(p=0.050)。应对策略:认为情况的发生是因为别人(p=0.031),向某人抱怨或发泄(p<0.001),表现出敌意(p=0.018),过度饮酒和饮食以补偿或忘记发生的事情(p<0.001),大喊大叫和咒骂(p<0.001)多用于中年人。老年人更倾向于相信上帝或更高的存在或力量(p=0.012)。中年组负性情绪表达多(p<0.001),情绪抑制多(p=0.002)。研究结果突出了老年人在2019冠状病毒病大流行期间的复原力,并进一步了解了与大流行相关的压力源对年龄相关的心理社会功能的影响。
{"title":"Quality of life and coping strategies in the Covid-19 pandemic: Comparison analysis between middle-aged and eldery people","authors":"","doi":"10.37118/ijdr.26908.07.2023","DOIUrl":"https://doi.org/10.37118/ijdr.26908.07.2023","url":null,"abstract":"The emergence of the coronavirus disease (COVID-19) has triggered a global public health crisis and posed an unprecedented threat to mental health worldwide. The aim of this study was to compare quality of life variables and coping strategies during the COVID-19 pandemic between two different age groups: middle-aged people and elderly people. Descriptive and comparative studies were carried out. The study has a quantitative, correlational and cross-sectional design. The sample was for convenience and not probabilistic. 311 people aged over 40 years were interviewed. The following evaluation instruments were used: socio-demographic data, EUROHIS- QOL and the Coping Strategies Inventory. For the comparative study of means, the Mann-Whitney U test was used, with a significance level ≤. 0.05. For the statistical study, IBM-SPSS, v. 28.0. A statistically significant relationship (p<0.001) was identified with respect to the variable satisfaction with personal relationships during the pandemic, being higher among the group of elderly people. Coping strategies were more used by the middle-aged group (p=0.050). Coping strategies: thought that the situation happened because of others (p=0.031), complained or vented to someone (p<0.001), showed hostility (p=0.018), drank and ate excessively to compensate or to forget what was happening (p<0.001), shouting and swearing (p<0.001) were more used by middle-aged people. The strategy trusted in God or in some higher being or force was more used by elderly participants (p=0.012). The expression of negative emotions was more used by the middle-aged group (p<0.001) and the inhibition of emotions as well (p=0.002). The results highlight the resilience of older adults during the COVID-19 pandemic and provide additional insight into the influence of pandemic-related stressors on age-related psychosocial functioning.","PeriodicalId":13916,"journal":{"name":"International Journal of Drug Development and Research","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-07-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75746992","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
期刊
International Journal of Drug Development and Research
全部 Acc. Chem. Res. ACS Applied Bio Materials ACS Appl. Electron. Mater. ACS Appl. Energy Mater. ACS Appl. Mater. Interfaces ACS Appl. Nano Mater. ACS Appl. Polym. Mater. ACS BIOMATER-SCI ENG ACS Catal. ACS Cent. Sci. ACS Chem. Biol. ACS Chemical Health & Safety ACS Chem. Neurosci. ACS Comb. Sci. ACS Earth Space Chem. ACS Energy Lett. ACS Infect. Dis. ACS Macro Lett. ACS Mater. Lett. ACS Med. Chem. Lett. ACS Nano ACS Omega ACS Photonics ACS Sens. ACS Sustainable Chem. Eng. ACS Synth. Biol. Anal. Chem. BIOCHEMISTRY-US Bioconjugate Chem. BIOMACROMOLECULES Chem. Res. Toxicol. Chem. Rev. Chem. Mater. CRYST GROWTH DES ENERG FUEL Environ. Sci. Technol. Environ. Sci. Technol. Lett. Eur. J. Inorg. Chem. IND ENG CHEM RES Inorg. Chem. J. Agric. Food. Chem. J. Chem. Eng. Data J. Chem. Educ. J. Chem. Inf. Model. J. Chem. Theory Comput. J. Med. Chem. J. Nat. Prod. J PROTEOME RES J. Am. Chem. Soc. LANGMUIR MACROMOLECULES Mol. Pharmaceutics Nano Lett. Org. Lett. ORG PROCESS RES DEV ORGANOMETALLICS J. Org. Chem. J. Phys. Chem. J. Phys. Chem. A J. Phys. Chem. B J. Phys. Chem. C J. Phys. Chem. Lett. Analyst Anal. Methods Biomater. Sci. Catal. Sci. Technol. Chem. Commun. Chem. Soc. Rev. CHEM EDUC RES PRACT CRYSTENGCOMM Dalton Trans. Energy Environ. Sci. ENVIRON SCI-NANO ENVIRON SCI-PROC IMP ENVIRON SCI-WAT RES Faraday Discuss. Food Funct. Green Chem. Inorg. Chem. Front. Integr. Biol. J. Anal. At. Spectrom. J. Mater. Chem. A J. Mater. Chem. B J. Mater. Chem. C Lab Chip Mater. Chem. Front. Mater. Horiz. MEDCHEMCOMM Metallomics Mol. Biosyst. Mol. Syst. Des. Eng. Nanoscale Nanoscale Horiz. Nat. Prod. Rep. New J. Chem. Org. Biomol. Chem. Org. Chem. Front. PHOTOCH PHOTOBIO SCI PCCP Polym. Chem.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1