Pub Date : 2023-07-28DOI: 10.37118/ijdr.26926.07.2023
The burden of low vision is rapidly increasing globally, and cally, in the developing world. The study aims to more speci nal assess various commonly used low visual aids and the outcome in patients. 36 patients with low vision were examined, investigated and treated by the author in the period between Dec 2018 to April 2019, using a variety of new instruments and rehabilitation techniques. Following this, there was improvement in visual acuity in 32 patients as well as improvement in quality of living where patients were able to undertake several household and profession related tasks and activities. Through this, the author concludes that for low vision patients, following proper diagnosis, and treatment, proper rehabilitation tools and techniques are needed to bring improvement the quality of life.
{"title":"Vision miracles for daily living enhancement","authors":"","doi":"10.37118/ijdr.26926.07.2023","DOIUrl":"https://doi.org/10.37118/ijdr.26926.07.2023","url":null,"abstract":"The burden of low vision is rapidly increasing globally, and cally, in the developing world. The study aims to more speci nal assess various commonly used low visual aids and the outcome in patients. 36 patients with low vision were examined, investigated and treated by the author in the period between Dec 2018 to April 2019, using a variety of new instruments and rehabilitation techniques. Following this, there was improvement in visual acuity in 32 patients as well as improvement in quality of living where patients were able to undertake several household and profession related tasks and activities. Through this, the author concludes that for low vision patients, following proper diagnosis, and treatment, proper rehabilitation tools and techniques are needed to bring improvement the quality of life.","PeriodicalId":13916,"journal":{"name":"International Journal of Drug Development and Research","volume":"8 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-07-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81857864","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-07-28DOI: 10.37118/ijdr.26938.07.2023
The object of this study was to examine the Body temperature and Blood oxygen level (SpO2) between Women in area of Pune District especially in Junnar Tahasil urban and Ruler area. For this research, population form Junnar Nagarpalica area have been selected as population a total of 60 among them 30 urban women and 30 Ruler women age group of 21 to 40 years old. The test was conducted during the Maharashtra governments policy of “Maze Kutumba Mazi Zababdari” during Covid-19 Pandemics in 2020, so government permitted particular area for test and the particular data was submitted to government agencies also. Samples for this research were women in urban and Ruler area of Pune District especially in Junnar Tahasil area. Researcher took around 300 test (Morning at 9.00am.to11.30 am.) for every person in that area but children, men and senior citizens were excluded from this study so researcher have been selected total of 60 women age group of 21 to 40 years old population for particular study. For this study body temperature was measured by Digital Thermometer and blood oxygen level was measured by Pulse Oximeter. For these studies, Descriptive statistics, and Independent sample t-test used for the data analysis. Results: This particular research researcher shows that the Body temperature of urban women and ruler women was normal (t-3.669: P 0.06 > 0.05) and also found that no significant difference in body temperature of urban women and ruler women. Blood oxygen level of urban women and ruler women was also normal (t- 2.91: P 0.79 < 0.05) and significant difference found in SpO2 level of urban women and ruler women. There were no signs of any fever or infection. In this research researcher also shows the blood oxygen level of urban women and ruler women were normal so research conclude that no fever and infection sings found in any subject.
本研究的目的是研究普那地区特别是Junnar Tahasil城市和统治者地区妇女的体温和血氧水平(SpO2)。本研究选取Junnar Nagarpalica地区的人口作为人口，共60人，其中城市女性30人，统治者女性30人，年龄在21 - 40岁。该测试是在2020年新冠肺炎大流行期间马哈拉施特拉邦政府“迷宫库图姆巴Mazi Zababdari”政策期间进行的，因此政府允许特定区域进行测试，并将特定数据提交给政府机构。本研究的样本是普那地区的城市和统治者地区的妇女，特别是在Junnar Tahasil地区。研究人员对该地区的每个人进行了大约300次测试(上午9点至11点30分)，但儿童，男性和老年人被排除在这项研究之外，因此研究人员总共选择了60名年龄在21至40岁之间的女性进行特定研究。本研究采用数字体温计测量体温，脉搏血氧仪测量血氧水平。对于这些研究，使用描述性统计和独立样本t检验进行数据分析。结果:本研究表明城市女性和统治者女性的体温正常(t-3.669: P 0.06 > 0.05)，也发现城市女性和统治者女性的体温无显著差异。城市女性与统治者女性血氧水平均正常(t- 2.91: P 0.79 < 0.05)， SpO2水平与统治者女性差异有统计学意义。没有任何发烧或感染的迹象。在这项研究中，研究人员还表明，城市妇女和农村妇女的血氧水平都是正常的，因此研究得出结论，没有发现任何受试者发烧和感染。
{"title":"Assessing the body temperature and spo2 level during covid-19 pandemic among urban and ruler women","authors":"","doi":"10.37118/ijdr.26938.07.2023","DOIUrl":"https://doi.org/10.37118/ijdr.26938.07.2023","url":null,"abstract":"The object of this study was to examine the Body temperature and Blood oxygen level (SpO2) between Women in area of Pune District especially in Junnar Tahasil urban and Ruler area. For this research, population form Junnar Nagarpalica area have been selected as population a total of 60 among them 30 urban women and 30 Ruler women age group of 21 to 40 years old. The test was conducted during the Maharashtra governments policy of “Maze Kutumba Mazi Zababdari” during Covid-19 Pandemics in 2020, so government permitted particular area for test and the particular data was submitted to government agencies also. Samples for this research were women in urban and Ruler area of Pune District especially in Junnar Tahasil area. Researcher took around 300 test (Morning at 9.00am.to11.30 am.) for every person in that area but children, men and senior citizens were excluded from this study so researcher have been selected total of 60 women age group of 21 to 40 years old population for particular study. For this study body temperature was measured by Digital Thermometer and blood oxygen level was measured by Pulse Oximeter. For these studies, Descriptive statistics, and Independent sample t-test used for the data analysis. Results: This particular research researcher shows that the Body temperature of urban women and ruler women was normal (t-3.669: P 0.06 > 0.05) and also found that no significant difference in body temperature of urban women and ruler women. Blood oxygen level of urban women and ruler women was also normal (t- 2.91: P 0.79 < 0.05) and significant difference found in SpO2 level of urban women and ruler women. There were no signs of any fever or infection. In this research researcher also shows the blood oxygen level of urban women and ruler women were normal so research conclude that no fever and infection sings found in any subject.","PeriodicalId":13916,"journal":{"name":"International Journal of Drug Development and Research","volume":"11 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-07-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74524604","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-07-28DOI: 10.37118/ijdr.26965.07.2023
This is an in-vivo research conducted in the denture wearing population at PGIDS, Rohtak. The patients evaluated on their methods and frequency of oral and denture hygiene and their nocturnal denture wearing habits.
{"title":"Evaluation of complete denture hygiene and nocturnal wearing habits among patients reporting to pgids rohtak: An in-vivo study","authors":"","doi":"10.37118/ijdr.26965.07.2023","DOIUrl":"https://doi.org/10.37118/ijdr.26965.07.2023","url":null,"abstract":"This is an in-vivo research conducted in the denture wearing population at PGIDS, Rohtak. The patients evaluated on their methods and frequency of oral and denture hygiene and their nocturnal denture wearing habits.","PeriodicalId":13916,"journal":{"name":"International Journal of Drug Development and Research","volume":"181 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-07-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72694481","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-06-30DOI: 10.37118/ijdr.26875.06.2023
Recurring flood scenarios are globally, the most endemic, ubiquitous and dramatic natural hazards especially on low-lying and steep sloping areas. The area space covered by the settlements of Kumba, Mutengene and Tiko have these characteristic landscapes and flooding events common but those of July to September August to 2022 were not only record breaking but somewhat enigmatic in nature. This study sought to make an in-depth examination of probable triggers of the hydroclimatic catastrophe. The study adopted the mixed research design combining both quantitative and qualitative techniques. Primary data on the dimension of the flooding scenarios, the drivers were obtained through empirical research methods of direct and indirect field observations of affected areas. Daily, monthly and annual climatic data were sourced from NASA satellite database, and analysed to obtain temporal rainfall intensities and distribution patterns. Change detection of landcover and land uses were established through GIS analysis of satellite images between year 2000 and 2022. Impacts of the flood events were obtained through an exploratory survey of the flood impacted zones. The results revealed the principal trigger mechanism of the cataclysmic floods of July and September 2022 to be the disruption of the natural balance of the landscape linked to combined effects over the years, of intensifying high rainfall concentration within fewer months of the year, and the heightened vulnerability of the landscape due to uncontrolled land cover and land use mutations that have coerced anthropic colonisation of natural water course ways, to the extent that indigenous adaptation measures as raised foundations and sand bag embankments were dwarfed by the flood waters.Far reaching consequences registered were destruction of communication lines, infrastructural facilities, arable and pastoral farmlands and landscape spoliation by landslides. The recommends proper land use planning and improvement of drains systems as the sustainable preventive panacea to such a situation.
{"title":"Ascribing the capricious weather thes is to the unprecedented july-september 2022 flood hazards in the kumba and mutengene-likomba agglomerations of the south west cameroon coastal plain of cameroon","authors":"","doi":"10.37118/ijdr.26875.06.2023","DOIUrl":"https://doi.org/10.37118/ijdr.26875.06.2023","url":null,"abstract":"Recurring flood scenarios are globally, the most endemic, ubiquitous and dramatic natural hazards especially on low-lying and steep sloping areas. The area space covered by the settlements of Kumba, Mutengene and Tiko have these characteristic landscapes and flooding events common but those of July to September August to 2022 were not only record breaking but somewhat enigmatic in nature. This study sought to make an in-depth examination of probable triggers of the hydroclimatic catastrophe. The study adopted the mixed research design combining both quantitative and qualitative techniques. Primary data on the dimension of the flooding scenarios, the drivers were obtained through empirical research methods of direct and indirect field observations of affected areas. Daily, monthly and annual climatic data were sourced from NASA satellite database, and analysed to obtain temporal rainfall intensities and distribution patterns. Change detection of landcover and land uses were established through GIS analysis of satellite images between year 2000 and 2022. Impacts of the flood events were obtained through an exploratory survey of the flood impacted zones. The results revealed the principal trigger mechanism of the cataclysmic floods of July and September 2022 to be the disruption of the natural balance of the landscape linked to combined effects over the years, of intensifying high rainfall concentration within fewer months of the year, and the heightened vulnerability of the landscape due to uncontrolled land cover and land use mutations that have coerced anthropic colonisation of natural water course ways, to the extent that indigenous adaptation measures as raised foundations and sand bag embankments were dwarfed by the flood waters.Far reaching consequences registered were destruction of communication lines, infrastructural facilities, arable and pastoral farmlands and landscape spoliation by landslides. The recommends proper land use planning and improvement of drains systems as the sustainable preventive panacea to such a situation.","PeriodicalId":13916,"journal":{"name":"International Journal of Drug Development and Research","volume":"77 5-6","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72604075","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-06-30DOI: 10.37118/ijdr.26836.06.2023
In this study, nanoparticles of titanium dioxide (TiO2) and graphene were incorporated into a matrix of thermoplastic starch (TPS) obtained from cassava (Manihot esculenta Crantz) with the objective of producing a material for covering fruit, aiming to last the shelf life of food. The polymeric nanocomposites (NCPs) were obtained by the solvent dispersion method and, subsequently, the spray drying technique was used to obtain the material in powder form. The NCPs were characterized by Fourier transform infrared spectroscopy (FTIR), X-ray diffraction (XRD), fluidity index (MFI), dynamic light scattering (DLS), zeta potential (PZ) and UV absorption spectroscopy ultraviolet and visible (UV-vis). The main results showed that the polymeric suspension obtained from the pulverized nanocomposites presented characteristics for potential use in coating apples and guava, such as high efficiency in absorbing UV-A and UV-B radiation and high stability of the formed solutions. Furthermore, the fruit coating test proved that the developed solution improved the visual characteristics and significantly delayed the degradation process of the analyzed fruits, proving to be effective in offering greater longevity to the food, reducing exorbitant losses and waste that strongly impact positively the economy and the environment.
{"title":"Evaluation of the action and properties of thermoplastic starch / titanium dioxide / graphene nanocomposites obtained through spray drying for fruit covering","authors":"","doi":"10.37118/ijdr.26836.06.2023","DOIUrl":"https://doi.org/10.37118/ijdr.26836.06.2023","url":null,"abstract":"In this study, nanoparticles of titanium dioxide (TiO2) and graphene were incorporated into a matrix of thermoplastic starch (TPS) obtained from cassava (Manihot esculenta Crantz) with the objective of producing a material for covering fruit, aiming to last the shelf life of food. The polymeric nanocomposites (NCPs) were obtained by the solvent dispersion method and, subsequently, the spray drying technique was used to obtain the material in powder form. The NCPs were characterized by Fourier transform infrared spectroscopy (FTIR), X-ray diffraction (XRD), fluidity index (MFI), dynamic light scattering (DLS), zeta potential (PZ) and UV absorption spectroscopy ultraviolet and visible (UV-vis). The main results showed that the polymeric suspension obtained from the pulverized nanocomposites presented characteristics for potential use in coating apples and guava, such as high efficiency in absorbing UV-A and UV-B radiation and high stability of the formed solutions. Furthermore, the fruit coating test proved that the developed solution improved the visual characteristics and significantly delayed the degradation process of the analyzed fruits, proving to be effective in offering greater longevity to the food, reducing exorbitant losses and waste that strongly impact positively the economy and the environment.","PeriodicalId":13916,"journal":{"name":"International Journal of Drug Development and Research","volume":"40 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77464139","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-06-30DOI: 10.37118/ijdr.26749.06.2023
Introduction: Physical activity and sedentary behavior play crucial roles in human development and public health. Understanding the factors associated with these behaviors is essential, particularly in specific populations such as university professors. This study aimed to examine the prevalence of sedentary behavior and physical activity levels among university professors and identify associated factors. Method: This cross-sectional study included professors from two universities in Goiás, Brazil. Data were collected using an online questionnaire and the International Physical Activity Questionnaire (IPAQ-bref) to assess physical activity levels. Sedentary behavior was evaluated based on the time spent sitting on weekdays. Sociodemographic, work-related, clinical, and lifestyle variables were collected. Descriptive analyses, chi-square tests, and logistic regression analyses were conducted to analyze the data. Results: Among the 152 professors analyzed, 62.5% were classified as insufficiently active, whereas 37.5% were considered active. Regarding sedentary behavior, 23% reported sitting for 6 h or less, while 77% reported sedentary behavior. Factors associated with physical activity levels included body mass index, presence of acute or chronic diseases, teaching time, sleep quality, and musculoskeletal pain. Factors associated with sedentary behavior included body mass index, teaching time, area of work, and alcohol intake. Conclusion: This study revealed a high prevalence of insufficient physical activity and sedentary behavior among university professors. Several factors such as BMI, teaching time, and lifestyle variables were associated with these behaviors. These findings emphasize the need for interventions to promote physical activity and reduce sedentary behavior among university professors, especially during the COVID-19 pandemic.
{"title":"Physical activity level and sedentary behavior and associated predictors among university professors during the pandemic period by covid-19","authors":"","doi":"10.37118/ijdr.26749.06.2023","DOIUrl":"https://doi.org/10.37118/ijdr.26749.06.2023","url":null,"abstract":"Introduction: Physical activity and sedentary behavior play crucial roles in human development and public health. Understanding the factors associated with these behaviors is essential, particularly in specific populations such as university professors. This study aimed to examine the prevalence of sedentary behavior and physical activity levels among university professors and identify associated factors. Method: This cross-sectional study included professors from two universities in Goiás, Brazil. Data were collected using an online questionnaire and the International Physical Activity Questionnaire (IPAQ-bref) to assess physical activity levels. Sedentary behavior was evaluated based on the time spent sitting on weekdays. Sociodemographic, work-related, clinical, and lifestyle variables were collected. Descriptive analyses, chi-square tests, and logistic regression analyses were conducted to analyze the data. Results: Among the 152 professors analyzed, 62.5% were classified as insufficiently active, whereas 37.5% were considered active. Regarding sedentary behavior, 23% reported sitting for 6 h or less, while 77% reported sedentary behavior. Factors associated with physical activity levels included body mass index, presence of acute or chronic diseases, teaching time, sleep quality, and musculoskeletal pain. Factors associated with sedentary behavior included body mass index, teaching time, area of work, and alcohol intake. Conclusion: This study revealed a high prevalence of insufficient physical activity and sedentary behavior among university professors. Several factors such as BMI, teaching time, and lifestyle variables were associated with these behaviors. These findings emphasize the need for interventions to promote physical activity and reduce sedentary behavior among university professors, especially during the COVID-19 pandemic.","PeriodicalId":13916,"journal":{"name":"International Journal of Drug Development and Research","volume":"78 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87624193","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-06-30DOI: 10.37118/ijdr.26664.06.2023
Objectives: The objective of this study was to examine the clinical and microbiological effects of combining mangosteen peel extract (MPE) and demineralized freeze-dried bovine bone xenograft (DFDBBX) on the expression of fibroblast growth factor-2 (FGF-2), the amount of osteoblast, and the amount of osteoclast in the alveolar bone following Cavia cobaya tooth extraction. Tooth extraction followed by alveolar ridge resorption is an unavoidable physiological process. The combination of MPE and DFDBBX is expected to primarily provide osteoconductive properties as well as strengthen the graft in order to stimulate new bone formation. Materials and Methods: Fifty-six Cavia cobaya were divided into two groups for 7-day (group A) and 30-day (group B) examinations, respectively. Each group consisted of twenty-eight animals that received four treatments. In each treatment, seven Cavia cobaya were used. The bottom right incisor was extracted. In groups AI and BI, tooth sockets were filled with 25 grams of polyethylene glycol (PEG). Tooth sockets in groups AII and BII were filled with 0.5 grams of DFDBBX and 24.5 grams of PEG. Tooth sockets in groups AIII and BIII were filled with 0.5 grams of MPE and 24.5 grams of PEG. In groups AIV and BIV, tooth sockets were filled with a mixture of 0.5 grams of DFDBBX, 0.5 grams of MPE, and 24 grams of PEG. Cavia cobaya's mandible was decalcified with ethylene diamine tetraacetic acid (EDTA) at 7 and 30 days. During this time, histopathology (HPA) and immunohistochemistry (IHC) tests were also performed. Statistical analysis: The calculated amounts of osteoblasts, osteoclasts, and FGF-2 expression data were used in the one-way ANOVA test. Results: FGF2 expression and the number of osteoblasts increased significantly after 7-day and 30-day of examination. On the other hand, the number of osteoclasts decreased. Conclusion: The combination of MPE and DFDBBX effectively increases FGF-2 expression and the number of osteoblast cells while decreasing the number of osteoclast cells on the alveolar ridge of Cavia cobaya.
目的:研究山竹皮提取物(MPE)和脱矿冻干牛骨异种移植物(DFDBBX)联合应用对牙槽骨成纤维细胞生长因子-2 (FGF-2)表达、成骨细胞数量和破骨细胞数量的临床和微生物学影响。拔牙后牙槽嵴吸收是一个不可避免的生理过程。MPE和DFDBBX的结合有望主要提供骨传导性能，并加强移植物以刺激新骨形成。材料与方法:将56只鱼子狸分为两组，分别进行7 d (A组)和30 d (B组)的检验。每组28只动物接受4种治疗。在每个治疗中，使用7只海茱萸。右下切牙拔除。AI组和BI组牙槽内填充聚乙二醇(PEG) 25 g。AII组和BII组牙槽填充DFDBBX 0.5 g和PEG 24.5 g。AIII组和BIII组牙槽填充0.5 g MPE和24.5 g PEG。AIV组和BIV组牙槽内填充0.5 g DFDBBX、0.5 g MPE和24 g PEG的混合物。分别于第7、30天用乙二胺四乙酸(EDTA)脱钙。在此期间，还进行了组织病理学(HPA)和免疫组织化学(IHC)检测。统计分析:计算成骨细胞数量、破骨细胞数量和FGF-2表达数据采用单因素方差分析。结果:观察7天、30天后，FGF2表达及成骨细胞数量均明显增加。另一方面，破骨细胞数量减少。结论:MPE与DFDBBX联合使用可有效提高海胆牙槽嵴上FGF-2的表达和成骨细胞的数量，减少破骨细胞的数量。
{"title":"Mangosteen peel extract (mpe) and dfdbbx applied to cavia cobaya tooth extraction sockets for guided bone regeneration","authors":"","doi":"10.37118/ijdr.26664.06.2023","DOIUrl":"https://doi.org/10.37118/ijdr.26664.06.2023","url":null,"abstract":"Objectives: The objective of this study was to examine the clinical and microbiological effects of combining mangosteen peel extract (MPE) and demineralized freeze-dried bovine bone xenograft (DFDBBX) on the expression of fibroblast growth factor-2 (FGF-2), the amount of osteoblast, and the amount of osteoclast in the alveolar bone following Cavia cobaya tooth extraction. Tooth extraction followed by alveolar ridge resorption is an unavoidable physiological process. The combination of MPE and DFDBBX is expected to primarily provide osteoconductive properties as well as strengthen the graft in order to stimulate new bone formation. Materials and Methods: Fifty-six Cavia cobaya were divided into two groups for 7-day (group A) and 30-day (group B) examinations, respectively. Each group consisted of twenty-eight animals that received four treatments. In each treatment, seven Cavia cobaya were used. The bottom right incisor was extracted. In groups AI and BI, tooth sockets were filled with 25 grams of polyethylene glycol (PEG). Tooth sockets in groups AII and BII were filled with 0.5 grams of DFDBBX and 24.5 grams of PEG. Tooth sockets in groups AIII and BIII were filled with 0.5 grams of MPE and 24.5 grams of PEG. In groups AIV and BIV, tooth sockets were filled with a mixture of 0.5 grams of DFDBBX, 0.5 grams of MPE, and 24 grams of PEG. Cavia cobaya's mandible was decalcified with ethylene diamine tetraacetic acid (EDTA) at 7 and 30 days. During this time, histopathology (HPA) and immunohistochemistry (IHC) tests were also performed. Statistical analysis: The calculated amounts of osteoblasts, osteoclasts, and FGF-2 expression data were used in the one-way ANOVA test. Results: FGF2 expression and the number of osteoblasts increased significantly after 7-day and 30-day of examination. On the other hand, the number of osteoclasts decreased. Conclusion: The combination of MPE and DFDBBX effectively increases FGF-2 expression and the number of osteoblast cells while decreasing the number of osteoclast cells on the alveolar ridge of Cavia cobaya.","PeriodicalId":13916,"journal":{"name":"International Journal of Drug Development and Research","volume":"5 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87889538","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-06-30DOI: 10.37118/ijdr.26901.06.2023
Introduction: Keratoconus (KC) is a chronic, progressive pathology that causes visual concern, in young patients the condition is more advanced with a faster progression of the disease. Treatment in pediatrics is mainly respiratory, among the most used methods is keratoplasty. Objective: To evaluate the profile of keratoplasty used in the correction of keratoconus in children and the main complications that this method entails for pediatric health. Method: The research is a systematic literature review, descriptive and qualitative. The bibliographic research was carried out in the databases, BVS, PUBMED SciELO and Cochrane Library. Results: After the survey and selection of articles, a total of 13 articles were obtained. Discussion: When the efficiency of DALK and PK was not observed significant difference in the results between the two types of keratoplasty, the cases of graft epitheliopathy and suture-associated complications that were associated with DALK are due to poor quality donor tissue. In addition, new therapies are promising and less invasive, such as CXL. Conclusion: The decision on the correct management of keratoconus includes extensive knowledge about the intercurrences that may occur during and after emergency treatment.
{"title":"Perfil de ceratoplastia por ceratocone em crianças: uma revisão crítica de literatura","authors":"","doi":"10.37118/ijdr.26901.06.2023","DOIUrl":"https://doi.org/10.37118/ijdr.26901.06.2023","url":null,"abstract":"Introduction: Keratoconus (KC) is a chronic, progressive pathology that causes visual concern, in young patients the condition is more advanced with a faster progression of the disease. Treatment in pediatrics is mainly respiratory, among the most used methods is keratoplasty. Objective: To evaluate the profile of keratoplasty used in the correction of keratoconus in children and the main complications that this method entails for pediatric health. Method: The research is a systematic literature review, descriptive and qualitative. The bibliographic research was carried out in the databases, BVS, PUBMED SciELO and Cochrane Library. Results: After the survey and selection of articles, a total of 13 articles were obtained. Discussion: When the efficiency of DALK and PK was not observed significant difference in the results between the two types of keratoplasty, the cases of graft epitheliopathy and suture-associated complications that were associated with DALK are due to poor quality donor tissue. In addition, new therapies are promising and less invasive, such as CXL. Conclusion: The decision on the correct management of keratoconus includes extensive knowledge about the intercurrences that may occur during and after emergency treatment.","PeriodicalId":13916,"journal":{"name":"International Journal of Drug Development and Research","volume":"7 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73547103","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-06-30DOI: 10.37118/ijdr.26855.06.2023
Palliative care improves the quality of life for patients with life-threatening illnesses, their families and medical staff. They should be performed early in the process of disease evolution, always in conjunction with curative therapy. We investigated which influences are related to the conduct of palliative care in Brazilian children. Data were analyzed qualitatively by the software IRAMUTEQ (Interface de R pour les Analyzes Multidimensionnelles de Textes et de Questionnaires). The analysis performed by IRAMUTEQ selected words with p<0.05. The process of pre-testing the questions was carried out with pediatricians from the institution where the researcher works, to analyze the perception of these professionals regarding the applicability of the questions and their objectives in relation to the various questions about pediatric palliative care found in the scientific literature. The instrument was validated and 236 questionnaires were subsequently sent to physicians from the National Academy of Palliative Care, between July 2018 and December 2019, who worked with this care in the Brazilian child population. The bibliographic material was obtained by searching the Scielo, Lilacs, Cochrane and Pubmed databases for articles published until 2020, selected for their relevance in the scientific literature. Ethical recommendations for research with human subjects were followed. In pediatrics, the understanding of palliative care is often mistaken or incomplete when it is assumed that it is only applied in the final stage of the disease. Health professionals must provide this care not only to patients, but also to family members, even after death, in a multidisciplinary and personalized way. There are difficulties in implementing palliative care. In Brazil. It was possible to observe that health professionals have difficulties, resulting from different influences, which make communication and care with the child and their family difficult in relation to death. There are several influences that make it difficult to conduct palliative care and that need to be worked on in their fields by the multiprofessional team, together with the family, with a tendency to create a new culture based on the true meaning of palliative care.
姑息治疗改善了危及生命的疾病患者、其家属和医务人员的生活质量。这些检查应在疾病发展的早期进行，并始终与治疗相结合。我们调查了哪些影响与巴西儿童姑息治疗的行为有关。数据采用IRAMUTEQ (Interface de R pour les analyses multidimensionneles de Textes et de questionnaire)软件进行定性分析。IRAMUTEQ选取p<0.05的词进行分析。问卷的预测过程由研究人员所在机构的儿科医生进行，以分析这些专业人员对问题的适用性的看法，以及他们对科学文献中发现的关于儿科姑息治疗的各种问题的目标。该工具经过验证，随后在2018年7月至2019年12月期间向国家姑息治疗学院的医生发送了236份问卷，这些医生在巴西儿童群体中使用这种护理方法。文献资料是通过检索Scielo、Lilacs、Cochrane和Pubmed数据库中发表到2020年的文章获得的，这些文章是根据与科学文献的相关性选择的。遵循了以人类为研究对象的伦理建议。在儿科，姑息治疗的理解往往是错误的或不完整的，当它被认为只适用于疾病的最后阶段。卫生专业人员必须以多学科和个性化的方式不仅向病人提供这种护理，而且还要向家属提供这种护理，甚至在他们死后也是如此。实施姑息治疗存在困难。在巴西。可以看到，由于不同的影响，保健专业人员在与死亡有关的问题上存在困难，这使得与儿童及其家庭的沟通和护理变得困难。有几种影响因素使实施姑息治疗变得困难，需要由多专业团队与家庭一起在各自的领域进行研究，并倾向于创造一种基于姑息治疗真正意义的新文化。
{"title":"Influences that are connected to the beginning and conduct of palliative care in pediatrics","authors":"","doi":"10.37118/ijdr.26855.06.2023","DOIUrl":"https://doi.org/10.37118/ijdr.26855.06.2023","url":null,"abstract":"Palliative care improves the quality of life for patients with life-threatening illnesses, their families and medical staff. They should be performed early in the process of disease evolution, always in conjunction with curative therapy. We investigated which influences are related to the conduct of palliative care in Brazilian children. Data were analyzed qualitatively by the software IRAMUTEQ (Interface de R pour les Analyzes Multidimensionnelles de Textes et de Questionnaires). The analysis performed by IRAMUTEQ selected words with p<0.05. The process of pre-testing the questions was carried out with pediatricians from the institution where the researcher works, to analyze the perception of these professionals regarding the applicability of the questions and their objectives in relation to the various questions about pediatric palliative care found in the scientific literature. The instrument was validated and 236 questionnaires were subsequently sent to physicians from the National Academy of Palliative Care, between July 2018 and December 2019, who worked with this care in the Brazilian child population. The bibliographic material was obtained by searching the Scielo, Lilacs, Cochrane and Pubmed databases for articles published until 2020, selected for their relevance in the scientific literature. Ethical recommendations for research with human subjects were followed. In pediatrics, the understanding of palliative care is often mistaken or incomplete when it is assumed that it is only applied in the final stage of the disease. Health professionals must provide this care not only to patients, but also to family members, even after death, in a multidisciplinary and personalized way. There are difficulties in implementing palliative care. In Brazil. It was possible to observe that health professionals have difficulties, resulting from different influences, which make communication and care with the child and their family difficult in relation to death. There are several influences that make it difficult to conduct palliative care and that need to be worked on in their fields by the multiprofessional team, together with the family, with a tendency to create a new culture based on the true meaning of palliative care.","PeriodicalId":13916,"journal":{"name":"International Journal of Drug Development and Research","volume":"20 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76750047","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-06-30DOI: 10.37118/ijdr.26845.06.2023
Background: Chronic Obstructive Pulmonary Disease is very common in general population. It is a slowly progressing disease involving the airways or pulmonary parenchyma resulting in airflow obstruction. The main objective of the study was to determine the effectiveness of interventional package on pulmonary functional parameters among patients with chronic obstructive pulmonary disease in experimental group. Materials and Methods: The research design adopted was quasi experimental with two group pre test post test design. Purposive sampling technique was followed to obtain a sample of 30 COPD patients (15 COPD patients in experimental groups and 15 COPD patients in control groups) Pre test and post test assessment was done by using pulmonary functional parameters. Results: The post -test results depicted that 26.66% of the samples from the experimental group was having mild dyspnea, 53.33% moderate and 20% severe whereas 13.33% of the samples from the control group were having mild dyspnea, 40% moderate and 46.66% severe dyspnea. Conclusion: The findings of the present study concluded that the there was significant improvement in the lung functions and breath holding time and also reduction the severity of dyspnea in the experimental group.
{"title":"Effectiveness of interventional package on pulmonary functional parameters among patients with chronic obstructive pulmonary disease in selected hospital at gandhinagar","authors":"","doi":"10.37118/ijdr.26845.06.2023","DOIUrl":"https://doi.org/10.37118/ijdr.26845.06.2023","url":null,"abstract":"Background: Chronic Obstructive Pulmonary Disease is very common in general population. It is a slowly progressing disease involving the airways or pulmonary parenchyma resulting in airflow obstruction. The main objective of the study was to determine the effectiveness of interventional package on pulmonary functional parameters among patients with chronic obstructive pulmonary disease in experimental group. Materials and Methods: The research design adopted was quasi experimental with two group pre test post test design. Purposive sampling technique was followed to obtain a sample of 30 COPD patients (15 COPD patients in experimental groups and 15 COPD patients in control groups) Pre test and post test assessment was done by using pulmonary functional parameters. Results: The post -test results depicted that 26.66% of the samples from the experimental group was having mild dyspnea, 53.33% moderate and 20% severe whereas 13.33% of the samples from the control group were having mild dyspnea, 40% moderate and 46.66% severe dyspnea. Conclusion: The findings of the present study concluded that the there was significant improvement in the lung functions and breath holding time and also reduction the severity of dyspnea in the experimental group.","PeriodicalId":13916,"journal":{"name":"International Journal of Drug Development and Research","volume":"114 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75481069","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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