首页 > 最新文献

International Journal of Environmental Health Research最新文献

英文 中文
Radiological assessment of radon concentration in cooking plates available in Erbil city, Kurdistan Region of Iraq. 伊拉克库尔德斯坦地区埃尔比勒市可用烹饪板中氡浓度的放射评估。
IF 1.9 4区 医学 Q3 ENVIRONMENTAL SCIENCES Pub Date : 2026-02-01 Epub Date: 2025-06-02 DOI: 10.1080/09603123.2025.2512414
Hawzhin Abdulkhaleq Asaad, Ali Hassan Ahmed

The evaluation of radon concentration in meal cooking plates is crucial, as radon gas is the second leading cause of lung cancer. For this purpose, 65 meal dish samples were collected in Erbil city. The radon concentration, surface exhalation rate, mass exhalation rate, and effective radon content, as well as the annual effective dose and excess lifetime cancer risk, were measured using a RAD-7 detector. The results demonstrate that the range of radon concentration, surface and mass exhalation rates, effective radon content, annual effective dose, and excess lifetime cancer risk in the studied samples are 14.2-80.1 Bq/m3, 0.027-0.151 Bq/m2. h, 0.86-3.83 mBq/kg. h, 0.114-0.508 Bq/kg, 0.356-2.021 mSv/y, and (1.25-7.07)×10-3 respectively. Radon concentrations in all samples fell below the ICRP's recommended activity range of 200-600 Bq/m3. The results indicated that the rate of radon release was less than the global average of 57.600 Bq/m2.h. Additionally, the annual effective dose for a minority of the samples (15 out of 65, or 23%) exceeded the global average value of 1.2 mSv/y. The study reveals a strong correlation between radon activity concentration, surface exhalation rate, and mass exhalation rate, suggesting that certain ceramic plate dishes in kitchens increase radon pollution levels.

由于氡气是导致肺癌的第二大原因,因此对饭菜烹饪板中氡浓度的评估至关重要。为此,在埃尔比勒市收集了65个餐碟样本。氡浓度、表面呼出率、质量呼出率、有效氡含量,以及年有效剂量和超额终身癌症风险,采用RAD-7检测仪测量。结果表明,研究样本的氡浓度、表面和质量呼出率、有效氡含量、年有效剂量和终生过量致癌风险范围分别为14.2 ~ 80.1 Bq/m3、0.027 ~ 0.151 Bq/m2。h, 0.86 ~ 3.83 mBq/kg。h、0.114 ~ 0.508 Bq/kg、0.356 ~ 2.021 mSv/y和(1.25 ~ 7.07)×10-3。所有样本的氡浓度均低于国际污染防治委员会建议的200-600 Bq/m3的活度范围。结果表明,该地区氡释放速率低于全球平均值57.600 Bq/m2.h。此外,少数样本(65个样本中的15个,即23%)的年有效剂量超过了1.2毫西弗/年的全球平均值。该研究揭示了氡活度浓度、表面呼出率和整体呼出率之间存在很强的相关性,这表明厨房中的某些陶瓷盘子会增加氡污染水平。
{"title":"Radiological assessment of radon concentration in cooking plates available in Erbil city, Kurdistan Region of Iraq.","authors":"Hawzhin Abdulkhaleq Asaad, Ali Hassan Ahmed","doi":"10.1080/09603123.2025.2512414","DOIUrl":"10.1080/09603123.2025.2512414","url":null,"abstract":"<p><p>The evaluation of radon concentration in meal cooking plates is crucial, as radon gas is the second leading cause of lung cancer. For this purpose, 65 meal dish samples were collected in Erbil city. The radon concentration, surface exhalation rate, mass exhalation rate, and effective radon content, as well as the annual effective dose and excess lifetime cancer risk, were measured using a RAD-7 detector. The results demonstrate that the range of radon concentration, surface and mass exhalation rates, effective radon content, annual effective dose, and excess lifetime cancer risk in the studied samples are 14.2-80.1 Bq/m<sup>3</sup>, 0.027-0.151 Bq/m<sup>2</sup>. h, 0.86-3.83 mBq/kg. h, 0.114-0.508 Bq/kg, 0.356-2.021 mSv/y, and (1.25-7.07)×10<sup>-3</sup> respectively. Radon concentrations in all samples fell below the ICRP's recommended activity range of 200-600 Bq/m<sup>3</sup>. The results indicated that the rate of radon release was less than the global average of 57.600 Bq/m<sup>2</sup>.h. Additionally, the annual effective dose for a minority of the samples (15 out of 65, or 23%) exceeded the global average value of 1.2 mSv/y. The study reveals a strong correlation between radon activity concentration, surface exhalation rate, and mass exhalation rate, suggesting that certain ceramic plate dishes in kitchens increase radon pollution levels.</p>","PeriodicalId":14039,"journal":{"name":"International Journal of Environmental Health Research","volume":" ","pages":"203-215"},"PeriodicalIF":1.9,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144199046","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Nature-based interventions system for the urban population with sub-healthy state: an analysis using the CiteSpace and VOSviewer. 基于自然的城市亚健康人群干预系统:基于CiteSpace和VOSviewer的分析
IF 1.9 4区 医学 Q3 ENVIRONMENTAL SCIENCES Pub Date : 2026-02-01 Epub Date: 2025-06-10 DOI: 10.1080/09603123.2025.2518165
Bo Jiang, Binxia Xue, Tongyu Li, Claudia Kam Yuk Lai, Anna Maria Pálsdóttir, Msasi Lilian

Amid rapid urbanization and rising health challenges, nature-based interventions (NBI) have emerged as a multidisciplinary focus for enhancing well-being and environmental sustainability. This study analyzed 35,418 publications from the Web of Science (1985-2023) using bibliometric tools (CiteSpace, VOSviewer) to map trends in NBI research. The annual number of publications, research institutions, and keywords were systematically analyzed. The conclusions drawn from this analysis are as follows: (1) The annual publication volume in the field of nature-based interventions has been steadily growing, reflecting the rising interest and recognition of its importance within the research community; (2) The research direction is gradually exhibiting diverse characteristics, spanning multiple disciplinary fields; (3) The current research predominantly emphasizes on four dimensions of nature-based interventions: physiological therapy, mental health, rehabilitation effects of physical activity, and the enhancement of quality of life across various population group. However, systematic exploration of the benefits of nature-based interventions for the sub-healthy population remains limited particularly concerning their impact on social health. Therefore, future research should place greater emphasis on examining the interactive relationship between nature-based interventions and the social health of sub-healthy populations, offering valuable references and inspiration for further research.

在快速城市化和不断增加的健康挑战中,基于自然的干预措施(NBI)已成为提高福祉和环境可持续性的多学科重点。本研究使用文献计量工具(CiteSpace, VOSviewer)分析了1985-2023年间来自Web of Science的35,418篇出版物,绘制了NBI研究的趋势图。系统分析年度出版物数量、研究机构数量、关键词数量。从分析中得出的结论如下:(1)基于自然的干预领域的年度出版物量稳步增长,反映了研究界对其重要性的兴趣和认识不断上升;(2)研究方向逐渐呈现多元化特征,跨越多学科领域;(3)目前的研究主要侧重于基于自然的干预的四个维度:生理治疗、心理健康、体育活动的康复效果和提高不同人群的生活质量。然而,对基于自然的干预措施对亚健康人群的益处的系统探索仍然有限,特别是关于它们对社会健康的影响。因此,未来的研究应更加注重研究基于自然的干预措施与亚健康人群社会健康之间的互动关系,为进一步的研究提供有价值的参考和启示。
{"title":"Nature-based interventions system for the urban population with sub-healthy state: an analysis using the CiteSpace and VOSviewer.","authors":"Bo Jiang, Binxia Xue, Tongyu Li, Claudia Kam Yuk Lai, Anna Maria Pálsdóttir, Msasi Lilian","doi":"10.1080/09603123.2025.2518165","DOIUrl":"10.1080/09603123.2025.2518165","url":null,"abstract":"<p><p>Amid rapid urbanization and rising health challenges, nature-based interventions (NBI) have emerged as a multidisciplinary focus for enhancing well-being and environmental sustainability. This study analyzed 35,418 publications from the Web of Science (1985-2023) using bibliometric tools (CiteSpace, VOSviewer) to map trends in NBI research. The annual number of publications, research institutions, and keywords were systematically analyzed. The conclusions drawn from this analysis are as follows: (1) The annual publication volume in the field of nature-based interventions has been steadily growing, reflecting the rising interest and recognition of its importance within the research community; (2) The research direction is gradually exhibiting diverse characteristics, spanning multiple disciplinary fields; (3) The current research predominantly emphasizes on four dimensions of nature-based interventions: physiological therapy, mental health, rehabilitation effects of physical activity, and the enhancement of quality of life across various population group. However, systematic exploration of the benefits of nature-based interventions for the sub-healthy population remains limited particularly concerning their impact on social health. Therefore, future research should place greater emphasis on examining the interactive relationship between nature-based interventions and the social health of sub-healthy populations, offering valuable references and inspiration for further research.</p>","PeriodicalId":14039,"journal":{"name":"International Journal of Environmental Health Research","volume":" ","pages":"262-275"},"PeriodicalIF":1.9,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144258052","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Spatial mapping of dengue incidence with climate factors at district levels in Bangladesh. 孟加拉国各区登革热发病率与气候因素的空间制图。
IF 1.9 4区 医学 Q3 ENVIRONMENTAL SCIENCES Pub Date : 2026-02-01 Epub Date: 2025-05-30 DOI: 10.1080/09603123.2025.2511800
Sorif Hossain, Abid Hasan, Md Momin Islam, Mamun Miah, Bazlur Rashid, Kabirul Bashar, Rabiul Awal

This study investigates the spatial distribution of dengue incidence in Bangladesh and its correlation with climate factors at the district level. Data from the Institute for Epidemiology, Disease Control and Research (IEDCR), Directorate General of Health Services (DGHS), and Bangladesh Meteorological Department (BMD) were used. Poisson, zero-inflated, and negative binomial models were employed, with the negative binomial regression model selected based on Akaike Information Criterion (AIC) values. Spatial mapping revealed varying dengue incidence across districts, with higher transmission in specific areas. Temperature and rainfall significantly influenced dengue incidence. Notably, increases in minimum temperature were associated with higher dengue cases in districts such as Kurigram and Chapainawabganj. A negative relation was observed between maximum temperature and dengue cases (e.g. for Dhaka District, Exp(β) = 0.24, (95% CI: 0.14, 0.40)), while rainfall's impact varied by region, with notably increasing cases in Khulna (Exp(β) = 1.05, (95% CI: 1.04, 1.06)), Madaripur (Exp(β) = 1.28, (95% CI: 1.25, 1.31)), and Satkhira (Exp(β) = 1.15, (95% CI: 1.14, 1.16)). The study highlights the importance of incorporating spatial and climate factors into prevention efforts, aiding in proactive district-level strategies to mitigate dengue's public health burden in Bangladesh.

本研究调查了孟加拉国登革热发病率的空间分布及其与地区气候因子的相关性。使用了流行病学、疾病控制和研究所(IEDCR)、卫生服务总局(DGHS)和孟加拉国气象部门(BMD)的数据。采用泊松模型、零膨胀模型和负二项模型,并根据赤池信息准则(Akaike Information Criterion, AIC)值选择负二项回归模型。空间制图显示,不同地区的登革热发病率不同,特定地区的传播率较高。气温和降雨量对登革热发病率有显著影响。值得注意的是,Kurigram和chapainawganj等地区的最低气温升高与登革热病例增加有关。最高气温与登革热病例呈负相关(如达卡地区,Exp(β) = 0.24, (95% CI: 0.14, 0.40)),而降雨的影响因地区而异,库尔纳(Exp(β) = 1.05, (95% CI: 1.04, 1.06))、Madaripur (Exp(β) = 1.28, (95% CI: 1.25, 1.31))和Satkhira (Exp(β) = 1.15, (95% CI: 1.14, 1.16)的病例显著增加。该研究强调了将空间和气候因素纳入预防工作的重要性,有助于制定积极的地区一级战略,减轻孟加拉国登革热的公共卫生负担。
{"title":"Spatial mapping of dengue incidence with climate factors at district levels in Bangladesh.","authors":"Sorif Hossain, Abid Hasan, Md Momin Islam, Mamun Miah, Bazlur Rashid, Kabirul Bashar, Rabiul Awal","doi":"10.1080/09603123.2025.2511800","DOIUrl":"10.1080/09603123.2025.2511800","url":null,"abstract":"<p><p>This study investigates the spatial distribution of dengue incidence in Bangladesh and its correlation with climate factors at the district level. Data from the Institute for Epidemiology, Disease Control and Research (IEDCR), Directorate General of Health Services (DGHS), and Bangladesh Meteorological Department (BMD) were used. Poisson, zero-inflated, and negative binomial models were employed, with the negative binomial regression model selected based on Akaike Information Criterion (AIC) values. Spatial mapping revealed varying dengue incidence across districts, with higher transmission in specific areas. Temperature and rainfall significantly influenced dengue incidence. Notably, increases in minimum temperature were associated with higher dengue cases in districts such as Kurigram and Chapainawabganj. A negative relation was observed between maximum temperature and dengue cases (e.g. for Dhaka District, Exp(β) = 0.24, (95% CI: 0.14, 0.40)), while rainfall's impact varied by region, with notably increasing cases in Khulna (Exp(β) = 1.05, (95% CI: 1.04, 1.06)), Madaripur (Exp(β) = 1.28, (95% CI: 1.25, 1.31)), and Satkhira (Exp(β) = 1.15, (95% CI: 1.14, 1.16)). The study highlights the importance of incorporating spatial and climate factors into prevention efforts, aiding in proactive district-level strategies to mitigate dengue's public health burden in Bangladesh.</p>","PeriodicalId":14039,"journal":{"name":"International Journal of Environmental Health Research","volume":" ","pages":"182-193"},"PeriodicalIF":1.9,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144186972","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A comparison of the effects of temperature change between neighboring days and diurnal temperature range on stroke incidence in rural Northwest. 西北农村相邻日温差与日温差对脑卒中发病影响的比较
IF 1.9 4区 医学 Q3 ENVIRONMENTAL SCIENCES Pub Date : 2026-02-01 Epub Date: 2025-06-17 DOI: 10.1080/09603123.2025.2519746
Guangyu Zhai, Hang Li, Wenjuan Zhou

Studies on the effect of temperature variation on the number of hospitalizations for stroke-related diseases in rural Northwest China are rare, and there is a gap in related studies in Pingliang, a less developed city located in Northwest China. We collected hospitalization data for stroke patients covered by the New Rural Cooperative Medical Insurance in Pingliang City and meteorological data from the Gansu Meteorological Bureau. Using quasi-Poisson regression combined with distributed lag nonlinear models (DLNM), we compared the effects of temperature change between neighboring days (TCN) and diurnal temperature range (DTR) on stroke-related hospitalizations in rural areas. The analysis indicated that DTR exerted a significantly greater impact on stroke incidence than TCN (RR = 1.267, 95% CI: 1.193-1.346 vs. RR = 1.168, 95% CI: 1.055-1.293). Both DTR and TCN exhibited a nonlinear U-shaped relationship. Sex-stratified analysis revealed that men were more adversely affected by low TCN and DTR levels than women, whereas women exhibited a greater susceptibility to high TCN levels. An age-stratified analysis indicated that adults were more vulnerable to the effects of DTR than elderly, who were more affected by high TCN. No significant differences were observed across the age groups under low TCN conditions.

气温变化对西北农村脑卒中相关疾病住院人数影响的研究较少,而平凉市作为西北欠发达城市,相关研究还存在空白。我们收集了平凉市新型农村合作医疗保险范围内脑卒中患者的住院数据和甘肃省气象局的气象数据。采用拟泊松回归结合分布滞后非线性模型(DLNM),比较了相邻日温度变化(TCN)和昼夜温度变化(DTR)对农村地区卒中相关住院的影响。分析显示,DTR对脑卒中发生率的影响显著大于TCN (RR = 1.267, 95% CI: 1.193 ~ 1.346 vs. RR = 1.168, 95% CI: 1.055 ~ 1.293)。DTR和TCN均呈非线性u型关系。性别分层分析显示,低TCN和DTR水平对男性的不利影响大于女性,而女性对高TCN水平的易感性更大。一项年龄分层分析表明,成年人比老年人更容易受到DTR的影响,老年人更容易受到高TCN的影响。在低TCN条件下,各年龄组间无显著差异。
{"title":"A comparison of the effects of temperature change between neighboring days and diurnal temperature range on stroke incidence in rural Northwest.","authors":"Guangyu Zhai, Hang Li, Wenjuan Zhou","doi":"10.1080/09603123.2025.2519746","DOIUrl":"10.1080/09603123.2025.2519746","url":null,"abstract":"<p><p>Studies on the effect of temperature variation on the number of hospitalizations for stroke-related diseases in rural Northwest China are rare, and there is a gap in related studies in Pingliang, a less developed city located in Northwest China. We collected hospitalization data for stroke patients covered by the New Rural Cooperative Medical Insurance in Pingliang City and meteorological data from the Gansu Meteorological Bureau. Using quasi-Poisson regression combined with distributed lag nonlinear models (DLNM), we compared the effects of temperature change between neighboring days (TCN) and diurnal temperature range (DTR) on stroke-related hospitalizations in rural areas. The analysis indicated that DTR exerted a significantly greater impact on stroke incidence than TCN (RR = 1.267, 95% CI: 1.193-1.346 vs. RR = 1.168, 95% CI: 1.055-1.293). Both DTR and TCN exhibited a nonlinear U-shaped relationship. Sex-stratified analysis revealed that men were more adversely affected by low TCN and DTR levels than women, whereas women exhibited a greater susceptibility to high TCN levels. An age-stratified analysis indicated that adults were more vulnerable to the effects of DTR than elderly, who were more affected by high TCN. No significant differences were observed across the age groups under low TCN conditions.</p>","PeriodicalId":14039,"journal":{"name":"International Journal of Environmental Health Research","volume":" ","pages":"305-317"},"PeriodicalIF":1.9,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144316794","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Environmental bioprinting in forensic pathology: applications in DNA preservation and forensic identification. 环境生物打印在法医病理学:在DNA保存和法医鉴定中的应用。
IF 1.9 4区 医学 Q3 ENVIRONMENTAL SCIENCES Pub Date : 2026-02-01 Epub Date: 2025-05-12 DOI: 10.1080/09603123.2025.2504610
Phoka C Rathebe, Mota X Kholopo

Bioprinting is an advanced technology that enables the fabrication of complex three-dimensional (3D) biological structures by layering bio-inks embedded with cells to replicate natural tissues. Environmental bioprinting, an emerging field at the intersection of biotechnology and forensic science, presents new possibilities for forensic pathology by recreating biological tissues under specific environmental conditions. This narrative review explores how environmental bioprinting can enhance forensic investigations by generating tissue models that mimic real-world environmental influences such as temperature fluctuations, chemical exposure, and decomposition processes. Special attention is given to the resilience of dental pulp DNA, which remains intact under extreme environmental conditions, making it a crucial element in forensic identification. The review also examines how early childhood diet and dental structures contribute to forensic profiling by providing insights into an individual's nutritional background and regional influences. By leveraging bioprinting technology, forensic scientists can improve the accuracy of tissue reconstruction, DNA preservation, and forensic biometrics, especially in challenging cases involving mass disasters and unidentified mortal remains. This narrative review synthesizes existing literature on environmental bioprinting's forensic applications, emphasizing its potential to revolutionize forensic pathology by offering a controlled, replicable model for biological tissue analysis.

生物打印是一种先进的技术,通过嵌入细胞的分层生物墨水来复制自然组织,从而制造复杂的三维(3D)生物结构。环境生物打印是生物技术与法医学交叉的新兴领域,通过在特定环境条件下重建生物组织,为法医病理学提供了新的可能性。这篇叙述性综述探讨了环境生物打印如何通过生成模拟真实环境影响(如温度波动、化学暴露和分解过程)的组织模型来增强法医调查。特别关注牙髓DNA的弹性,它在极端环境条件下保持完整,使其成为法医鉴定的关键因素。该综述还研究了幼儿饮食和牙齿结构如何通过提供对个人营养背景和区域影响的见解来促进法医鉴定。通过利用生物打印技术,法医科学家可以提高组织重建、DNA保存和法医生物识别的准确性,特别是在涉及大规模灾难和身份不明的遗体的具有挑战性的案件中。这篇叙述性的综述综合了现有的关于环境生物打印的法医应用的文献,强调了它通过提供一个受控的、可复制的生物组织分析模型来彻底改变法医病理学的潜力。
{"title":"Environmental bioprinting in forensic pathology: applications in DNA preservation and forensic identification.","authors":"Phoka C Rathebe, Mota X Kholopo","doi":"10.1080/09603123.2025.2504610","DOIUrl":"10.1080/09603123.2025.2504610","url":null,"abstract":"<p><p>Bioprinting is an advanced technology that enables the fabrication of complex three-dimensional (3D) biological structures by layering bio-inks embedded with cells to replicate natural tissues. Environmental bioprinting, an emerging field at the intersection of biotechnology and forensic science, presents new possibilities for forensic pathology by recreating biological tissues under specific environmental conditions. This narrative review explores how environmental bioprinting can enhance forensic investigations by generating tissue models that mimic real-world environmental influences such as temperature fluctuations, chemical exposure, and decomposition processes. Special attention is given to the resilience of dental pulp DNA, which remains intact under extreme environmental conditions, making it a crucial element in forensic identification. The review also examines how early childhood diet and dental structures contribute to forensic profiling by providing insights into an individual's nutritional background and regional influences. By leveraging bioprinting technology, forensic scientists can improve the accuracy of tissue reconstruction, DNA preservation, and forensic biometrics, especially in challenging cases involving mass disasters and unidentified mortal remains. This narrative review synthesizes existing literature on environmental bioprinting's forensic applications, emphasizing its potential to revolutionize forensic pathology by offering a controlled, replicable model for biological tissue analysis.</p>","PeriodicalId":14039,"journal":{"name":"International Journal of Environmental Health Research","volume":" ","pages":"169-181"},"PeriodicalIF":1.9,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143996058","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Microplastic content of over-the-counter toothpastes from India: an in-vitro study. 印度非处方牙膏的微塑料含量:一项体外研究。
IF 1.9 4区 医学 Q3 ENVIRONMENTAL SCIENCES Pub Date : 2026-02-01 Epub Date: 2025-06-04 DOI: 10.1080/09603123.2025.2512413
Kavery Chengappa S, Ashwini Rao, Sowmya R Holla, Ramya Shenoy, Mithun Pai Bh, Praveen Jodalli, Avinash Br

Toothpaste, an indispensable oral care aid, has been the focal point of environmental and health concerns due to its composition, especially for the presence of microplastics, one of the many contentious components needing scrutiny. However, there is an immense dearth of studies in this context in India. Hence, this study was conceptualised to determine the presence of microplastics in over-the-counter toothpastes from India using the Fourier Transform Infrared Spectroscopy-Attenuated Total Reflectance (FTIR-ATR) technique. The 20 most popular toothpastes available on the Indian market were selected and examined to identify the presence of microplastics. The absorbance peaks corresponding to functional groups indicative of the compounds, polyamides, polyethene and polypropylenes were identified at different ranges in all 20 toothpastes examined. The polyamides presented characteristic absorbance peaks at 3268-3342 cm-1, 1639-1643 cm-1, 1200-1218 cm-1, 1090-1109 cm-1 and 870-929 cm-1, whereas for polyethylene and polypropylene the characteristic absorbance peaks were observed at 2854-2945 cm-1 and 1402-1415 cm-1, respectively. The presence of microplastics in all 20 samples of toothpastes indicates a pressing need for scrutiny at the premarket phase and for stringent implementation of the rules to ensure their complete elimination, thus safeguarding the health of the public and the environment.

牙膏是一种不可或缺的口腔护理辅助产品,由于其成分,特别是微塑料的存在,一直是环境和健康问题的焦点,微塑料是许多需要审查的有争议的成分之一。然而,在印度,这方面的研究非常缺乏。因此,本研究的概念是利用傅里叶变换红外光谱-衰减全反射(FTIR-ATR)技术确定印度非处方牙膏中微塑料的存在。研究人员挑选了印度市场上最受欢迎的20种牙膏,并对其进行了检测,以确定其中是否含有微塑料。在20种牙膏中,聚酰胺、聚乙烯和聚丙烯等化合物的官能团对应的吸光度峰分布在不同的范围。聚酰胺的特征吸光度峰在3268 ~ 3342 cm-1、1639 ~ 1643 cm-1、1200 ~ 1218 cm-1、1090 ~ 1109 cm-1和870 ~ 929 cm-1,而聚乙烯和聚丙烯的特征吸光度峰分别在2854 ~ 2945 cm-1和1402 ~ 1415 cm-1。所有20种牙膏样品中都含有微塑料,这表明迫切需要在上市前阶段进行审查,并严格执行规则,以确保完全消除微塑料,从而保障公众健康和环境。
{"title":"Microplastic content of over-the-counter toothpastes from India: an in-vitro study.","authors":"Kavery Chengappa S, Ashwini Rao, Sowmya R Holla, Ramya Shenoy, Mithun Pai Bh, Praveen Jodalli, Avinash Br","doi":"10.1080/09603123.2025.2512413","DOIUrl":"10.1080/09603123.2025.2512413","url":null,"abstract":"<p><p>Toothpaste, an indispensable oral care aid, has been the focal point of environmental and health concerns due to its composition, especially for the presence of microplastics, one of the many contentious components needing scrutiny. However, there is an immense dearth of studies in this context in India. Hence, this study was conceptualised to determine the presence of microplastics in over-the-counter toothpastes from India using the Fourier Transform Infrared Spectroscopy-Attenuated Total Reflectance (FTIR-ATR) technique. The 20 most popular toothpastes available on the Indian market were selected and examined to identify the presence of microplastics. The absorbance peaks corresponding to functional groups indicative of the compounds, polyamides, polyethene and polypropylenes were identified at different ranges in all 20 toothpastes examined. The polyamides presented characteristic absorbance peaks at 3268-3342 cm<sup>-1</sup>, 1639-1643 cm<sup>-1</sup>, 1200-1218 cm<sup>-1</sup>, 1090-1109 cm<sup>-1</sup> and 870-929 cm<sup>-1</sup>, whereas for polyethylene and polypropylene the characteristic absorbance peaks were observed at 2854-2945 cm<sup>-1</sup> and 1402-1415 cm<sup>-1</sup>, respectively. The presence of microplastics in all 20 samples of toothpastes indicates a pressing need for scrutiny at the premarket phase and for stringent implementation of the rules to ensure their complete elimination, thus safeguarding the health of the public and the environment.</p>","PeriodicalId":14039,"journal":{"name":"International Journal of Environmental Health Research","volume":" ","pages":"194-202"},"PeriodicalIF":1.9,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144215756","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Microbial safety and quality assessment of drinking water from various water sources in Punjab, India. 印度旁遮普不同水源饮用水的微生物安全和质量评价。
IF 1.9 4区 医学 Q3 ENVIRONMENTAL SCIENCES Pub Date : 2026-02-01 Epub Date: 2025-06-03 DOI: 10.1080/09603123.2025.2514597
Rahul Khanna, Keshani Bhushan

Waterborne illnesses caused by contaminated water are increasing due to lack of accessibility to clean drinking water. This study investigates the microbial safety and antibiotic resistance profiles of waterborne microbes in different drinking water sources of Ludhiana, Punjab. Using most probable number as the selection criteria, 66% samples showed the presence of coliforms and other microbes with count ranging from 3 to 2600/100 mL. Overall, 50% of tap water samples were found to be unacceptable, followed by submersible (25%) and filters/RO systems (20%). The results revealed the presence of microbial contaminants, including Pseudomonas spp. Staphylococcus spp. E. coli, Klebsiella spp. Salmonella spp. Enterococcus spp. Citrobacter spp. and Proteus spp. Furthermore, antibiotic susceptibility testing by well diffusion method showed high levels of resistance, particularly to β-lactams, trimethoprim/sulfamethoxazole, monobactam and cephalosporins, highlighting the critical issue of antibiotic-resistant bacteria (ARB) in water systems. Maximum multiple drug resistance index was seen in Enterococcus spp. (0.916), followed by Proteus spp. (0.83), Pseudomonas spp. and Staphylococcus spp. (0.58). The study underscores the importance of stringent necessity for water quality monitoring to mitigate the risks posed by ARB. Further, advanced molecular detection of antibiotic resistance genes is required to enable targeted interventions and prevent their spread.

由于缺乏清洁饮用水,受污染的水引起的水传播疾病正在增加。本研究调查了旁遮普卢迪亚纳不同饮用水源中水生微生物的安全性和抗生素耐药性。以最可能数为选择标准,66%的样品存在大肠菌群和其他微生物,计数范围为3 ~ 2600/100 mL。总体而言,50%的自来水样本不合格,其次是潜水水(25%)和过滤器/反渗透系统(20%)。结果显示,水体中存在假单胞菌、葡萄球菌、大肠杆菌、克雷伯氏菌、沙门氏菌、肠球菌、柠檬酸杆菌和变形杆菌等微生物污染物。此外,通过井扩散法进行的抗生素药敏试验显示,水体中存在高水平的耐药菌,特别是对β-内酰胺类、甲氧苄啶/磺胺甲恶唑类、单巴坦类和头孢菌素类,突出了水体中抗生素耐药菌(ARB)的问题。多重耐药指数最高的是肠球菌(0.916),其次是变形杆菌(0.83)、假单胞菌和葡萄球菌(0.58)。该研究强调了严格进行水质监测以减轻ARB带来的风险的重要性。此外,需要对抗生素耐药基因进行先进的分子检测,以实现有针对性的干预并防止其传播。
{"title":"Microbial safety and quality assessment of drinking water from various water sources in Punjab, India.","authors":"Rahul Khanna, Keshani Bhushan","doi":"10.1080/09603123.2025.2514597","DOIUrl":"10.1080/09603123.2025.2514597","url":null,"abstract":"<p><p>Waterborne illnesses caused by contaminated water are increasing due to lack of accessibility to clean drinking water. This study investigates the microbial safety and antibiotic resistance profiles of waterborne microbes in different drinking water sources of Ludhiana, Punjab. Using most probable number as the selection criteria, 66% samples showed the presence of coliforms and other microbes with count ranging from 3 to 2600/100 mL. Overall, 50% of tap water samples were found to be unacceptable, followed by submersible (25%) and filters/RO systems (20%). The results revealed the presence of microbial contaminants, including <i>Pseudomonas</i> spp. <i>Staphylococcus</i> spp. <i>E. coli, Klebsiella</i> spp. <i>Salmonella</i> spp. <i>Enterococcus</i> spp. <i>Citrobacter</i> spp. and <i>Proteus</i> spp. Furthermore, antibiotic susceptibility testing by well diffusion method showed high levels of resistance, particularly to β-lactams, trimethoprim/sulfamethoxazole, monobactam and cephalosporins, highlighting the critical issue of antibiotic-resistant bacteria (ARB) in water systems. Maximum multiple drug resistance index was seen in <i>Enterococcus</i> spp. (0.916), followed by <i>Proteus</i> spp. (0.83), <i>Pseudomonas</i> spp. and <i>Staphylococcus</i> spp. (0.58). The study underscores the importance of stringent necessity for water quality monitoring to mitigate the risks posed by ARB. Further, advanced molecular detection of antibiotic resistance genes is required to enable targeted interventions and prevent their spread.</p>","PeriodicalId":14039,"journal":{"name":"International Journal of Environmental Health Research","volume":" ","pages":"216-230"},"PeriodicalIF":1.9,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144215755","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Adverse eye effects of smoke exposure at prescribed burns in wildland firefighters. 野火消防员在规定的烧伤中暴露于烟雾对眼睛的不利影响。
IF 1.9 4区 医学 Q3 ENVIRONMENTAL SCIENCES Pub Date : 2026-02-01 Epub Date: 2025-07-06 DOI: 10.1080/09603123.2025.2519764
Sukanya Jaiswal, Blanka Golebiowski, Ha T Duong, Michele C Madigan, Isabelle Jalbert

Objective: Despite exposure to high concentrations of particulate matter (PM) and gases on the fire ground, little is known about the impact of wildfire smoke on the eye surface of wildland firefighters. This field study investigated the impact of smoke exposure at prescribed burns on the eye surface of Australian wildland firefighters.

Methods: Twenty-three firefighters (19-60 years, 78% male) were evaluated before and after four prescribed burns for eye symptoms and clinical signs of eye surface damage. Types of protective eyewear used were recorded and a subset of firefighters wore PM2.5 personal monitors.

Results: Symptoms of eye discomfort, dryness and foreign body sensation increased after the burns, along with epithelial staining scores, eye surface redness and palpebral conjunctival roughness. Tear film stability reduced after the burns. Group mean PM2.5 exposure during the burns ranged from 130 to 480 µg/m3. All firefighters reported wearing sunglasses or goggles 40% to 100% of the time during the burns. Four firefighters (17%) wore no eye protection for 20% to 90% of the time.

Conclusion: Wildland firefighters experience increased eye irritation and display eye surface clinical changes consistent with eye surface damage. Evidence-based recommendations on how to prevent and manage eye surface complications in firefighters are urgently needed.

目的:尽管暴露在火场的高浓度颗粒物(PM)和气体中,但野火烟雾对野火消防员眼表的影响知之甚少。这项实地研究调查了澳大利亚野外消防员在规定烧伤时暴露于烟雾对眼睛表面的影响。方法:对23名消防员(19-60岁,78%男性)在4次烧伤前后的眼部症状和眼表损伤的临床体征进行评估。记录了使用的防护眼镜类型,一部分消防员佩戴了PM2.5个人监测器。结果:烧伤后眼不适、眼干、异物感加重,上皮染色评分、眼表发红、睑结膜粗糙程度增加。烧伤后泪膜稳定性降低。烧伤期间各组平均PM2.5暴露量为130至480µg/m3。所有消防员都报告说,在烧伤过程中,40%到100%的时间都戴着太阳镜或护目镜。四名消防员(17%)在20%至90%的时间里不戴护目镜。结论:野外消防员的眼睛刺激增加,并表现出与眼表损伤一致的眼表临床变化。迫切需要关于如何预防和管理消防员眼表并发症的循证建议。
{"title":"Adverse eye effects of smoke exposure at prescribed burns in wildland firefighters.","authors":"Sukanya Jaiswal, Blanka Golebiowski, Ha T Duong, Michele C Madigan, Isabelle Jalbert","doi":"10.1080/09603123.2025.2519764","DOIUrl":"10.1080/09603123.2025.2519764","url":null,"abstract":"<p><strong>Objective: </strong>Despite exposure to high concentrations of particulate matter (PM) and gases on the fire ground, little is known about the impact of wildfire smoke on the eye surface of wildland firefighters. This field study investigated the impact of smoke exposure at prescribed burns on the eye surface of Australian wildland firefighters.</p><p><strong>Methods: </strong>Twenty-three firefighters (19-60 years, 78% male) were evaluated before and after four prescribed burns for eye symptoms and clinical signs of eye surface damage. Types of protective eyewear used were recorded and a subset of firefighters wore PM2.5 personal monitors.</p><p><strong>Results: </strong>Symptoms of eye discomfort, dryness and foreign body sensation increased after the burns, along with epithelial staining scores, eye surface redness and palpebral conjunctival roughness. Tear film stability reduced after the burns. Group mean PM2.5 exposure during the burns ranged from 130 to 480 µg/m<sup>3</sup>. All firefighters reported wearing sunglasses or goggles 40% to 100% of the time during the burns. Four firefighters (17%) wore no eye protection for 20% to 90% of the time.</p><p><strong>Conclusion: </strong>Wildland firefighters experience increased eye irritation and display eye surface clinical changes consistent with eye surface damage. Evidence-based recommendations on how to prevent and manage eye surface complications in firefighters are urgently needed.</p>","PeriodicalId":14039,"journal":{"name":"International Journal of Environmental Health Research","volume":" ","pages":"328-341"},"PeriodicalIF":1.9,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144575418","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Extraction of Yucca schidigera with deep eutectic solvents: bromatological, antioxidant, and antibacterial analysis. 深共晶溶剂提取丝兰:色谱、抗氧化及抗菌分析。
IF 1.9 4区 医学 Q3 ENVIRONMENTAL SCIENCES Pub Date : 2026-02-01 Epub Date: 2025-06-25 DOI: 10.1080/09603123.2025.2519765
Ana C Hernández-Cruz, Jaime Lizardi-Mendoza, Gloria G Morales-Figueroa, Marco A López-Mata, Ildefonso Guerrero-Encinas, Javier N González-González, Jesús F Ayala-Zavala, Melvin R Tapia-Rodriguez, Luis Quihui-Cota

Infections caused by Escherichiacoli, Staphylococcus aureus, Salmonella Typhimurium, and Listeria monocytogenes are linked to contaminated food or water, while antibiotic resistance limits treatment options. Plant extracts are considered potential alternatives, and deep eutectic solvents and natural deep eutectic solvents (DES and NADES) offer a sustainable approach to metabolite extraction. Yucca schidigera powder was extracted using butanol (YSBE) and a NADES composed of choline chloride and lactic acid at a 1:1 molar ratio (YS-NADES). Bromatological composition, saponin content, total phenols and flavonoids, emulsifying and foaming capacities, antioxidant activity, and antibacterial properties were analyzed. YSBE contained 25.43% saponins, while YS-NADES had 0.093%. YSBE had higher protein (0.73%) and carbohydrate (77.5%) content than YS-NADES (0.03% and 0.95%, respectively). Antioxidant activity (DPPH, TEAC, ORAC) was significantly higher in YSBE than in YS-NADES. Phenol and flavonoid concentrations were also greater in YSBE. E. coli showed less sensitivity to both extracts than S. Typhimurium, S. aureus, and L. monocytogenes, while S. Typhimurium was less sensitive to YS-NADES. This study provides insights into the bromatological composition, antioxidant potential, and antibacterial properties of Y. schidigera extracted with NADES, highlighting its potential applications.

大肠杆菌、金黄色葡萄球菌、鼠伤寒沙门氏菌和单核增生李斯特菌引起的感染与受污染的食物或水有关,而抗生素耐药性限制了治疗选择。植物提取物被认为是潜在的替代品,而深共晶溶剂和天然深共晶溶剂(DES和NADES)提供了一种可持续的代谢物提取方法。采用丁醇(YSBE)和氯化胆碱与乳酸按1:1摩尔比组成的NADES (YS-NADES)提取丝兰粉末。分析了其色谱组成、皂苷含量、总酚类和总黄酮、乳化发泡能力、抗氧化活性和抗菌性能。YSBE皂苷含量为25.43%,YS-NADES皂苷含量为0.093%。YSBE的蛋白质(0.73%)和碳水化合物(77.5%)含量高于YS-NADES(0.03%)和0.95%。YSBE抗氧化活性(DPPH、TEAC、ORAC)显著高于YS-NADES。YSBE的酚和类黄酮浓度也较高。大肠杆菌对这两种提取物的敏感性均低于鼠伤寒沙门氏菌、金黄色葡萄球菌和单核增生乳杆菌,而鼠伤寒沙门氏菌对YS-NADES的敏感性较低。本研究揭示了NADES提取的雪梨菌的色谱组成、抗氧化潜力和抗菌性能,突出了其潜在的应用前景。
{"title":"Extraction of <i>Yucca schidigera</i> with deep eutectic solvents: bromatological, antioxidant, and antibacterial analysis.","authors":"Ana C Hernández-Cruz, Jaime Lizardi-Mendoza, Gloria G Morales-Figueroa, Marco A López-Mata, Ildefonso Guerrero-Encinas, Javier N González-González, Jesús F Ayala-Zavala, Melvin R Tapia-Rodriguez, Luis Quihui-Cota","doi":"10.1080/09603123.2025.2519765","DOIUrl":"10.1080/09603123.2025.2519765","url":null,"abstract":"<p><p>Infections caused by <i>Escherichiacoli</i>, <i>Staphylococcus aureus</i>, <i>Salmonella</i> Typhimurium, and <i>Listeria monocytogenes</i> are linked to contaminated food or water, while antibiotic resistance limits treatment options. Plant extracts are considered potential alternatives, and deep eutectic solvents and natural deep eutectic solvents (DES and NADES) offer a sustainable approach to metabolite extraction. <i>Yucca schidigera</i> powder was extracted using butanol (YSBE) and a NADES composed of choline chloride and lactic acid at a 1:1 molar ratio (YS-NADES). Bromatological composition, saponin content, total phenols and flavonoids, emulsifying and foaming capacities, antioxidant activity, and antibacterial properties were analyzed. YSBE contained 25.43% saponins, while YS-NADES had 0.093%. YSBE had higher protein (0.73%) and carbohydrate (77.5%) content than YS-NADES (0.03% and 0.95%, respectively). Antioxidant activity (DPPH, TEAC, ORAC) was significantly higher in YSBE than in YS-NADES. Phenol and flavonoid concentrations were also greater in YSBE. <i>E. coli</i> showed less sensitivity to both extracts than <i>S</i>. Typhimurium, <i>S. aureus</i>, and <i>L. monocytogenes</i>, while <i>S</i>. Typhimurium was less sensitive to YS-NADES. This study provides insights into the bromatological composition, antioxidant potential, and antibacterial properties of <i>Y. schidigera</i> extracted with NADES, highlighting its potential applications.</p>","PeriodicalId":14039,"journal":{"name":"International Journal of Environmental Health Research","volume":" ","pages":"342-356"},"PeriodicalIF":1.9,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144496153","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
DEHP-associated toxic targets in endometrial carcinoma: prognostic value and immunological implications. 子宫内膜癌中dehp相关的毒性靶点:预后价值和免疫学意义。
IF 1.9 4区 医学 Q3 ENVIRONMENTAL SCIENCES Pub Date : 2026-01-30 DOI: 10.1080/09603123.2026.2621066
Minuo Yin, Huimin Zhang

Diethylhexyl phthalate (DEHP), a common plasticizer, has been associated with hormone disruption and carcinogenesis, but its molecular impact on uterine corpus endometrial carcinoma (UCEC) remains unclear. This study aims to computationally identify a gene signature based on known DEHP-associated toxic targets and evaluates their clinical and immunological relevance in UCEC. DEGs were intersected with DEHP targets from CTD and TargetNet databases. PPI networks, functional enrichment, and survival analyses were conducted. Prognostic genes were identified using Cox and LASSO regression. DEHP risk score models and nomograms were constructed. Immune infiltration was analyzed using ESTIMATE and ssGSEA algorithms. Molecular docking was performed via CB-Dock2. Seventy-five genetic targets linked to DEHP in toxicological databases were identified, and enrichment analyses revealed DEHP-related genes enriched in neurotransmission and hormone signaling pathways. Seven prognostic genes (HTR3A, GRM2, HTR6, THRB, TUBB2B, FOLH1, PGR) correlated with overall survival and histologic grade. The DEHP risk score effectively stratified patients. DEHP-THRB showed strongest binding affinity, suggesting direct toxicological interaction. This study characterizes a computationally derived gene signature associated with DEHP toxicity in UCEC, highlighting their prognostic and immunological significance as potential molecular footprints, while acknowledging that direct exposure inference requires future validation with measured biomonitoring data.

邻苯二甲酸二乙基己酯(DEHP)是一种常见的增塑剂,与激素干扰和致癌有关,但其对子宫内膜癌(UCEC)的分子影响尚不清楚。本研究旨在基于已知的dehp相关毒性靶点计算鉴定基因标记,并评估其在UCEC中的临床和免疫学相关性。deg与CTD和TargetNet数据库中的DEHP目标相交。进行了PPI网络、功能富集和生存分析。采用Cox和LASSO回归分析确定预后基因。构建DEHP风险评分模型和模态图。采用ESTIMATE和ssGSEA算法分析免疫浸润。通过CB-Dock2进行分子对接。在毒理学数据库中鉴定了75个与DEHP相关的遗传靶点,富集分析显示DEHP相关基因富集于神经传递和激素信号通路中。7个预后基因(HTR3A、GRM2、HTR6、THRB、TUBB2B、FOLH1、PGR)与总生存期和组织学分级相关。DEHP风险评分有效地对患者进行分层。DEHP-THRB的结合亲和力最强,提示有直接的毒理学作用。本研究描述了计算得出的与UCEC中DEHP毒性相关的基因特征,强调了它们作为潜在分子足迹的预后和免疫学意义,同时承认直接暴露推断需要未来通过测量的生物监测数据进行验证。
{"title":"DEHP-associated toxic targets in endometrial carcinoma: prognostic value and immunological implications.","authors":"Minuo Yin, Huimin Zhang","doi":"10.1080/09603123.2026.2621066","DOIUrl":"https://doi.org/10.1080/09603123.2026.2621066","url":null,"abstract":"<p><p>Diethylhexyl phthalate (DEHP), a common plasticizer, has been associated with hormone disruption and carcinogenesis, but its molecular impact on uterine corpus endometrial carcinoma (UCEC) remains unclear. This study aims to computationally identify a gene signature based on known DEHP-associated toxic targets and evaluates their clinical and immunological relevance in UCEC. DEGs were intersected with DEHP targets from CTD and TargetNet databases. PPI networks, functional enrichment, and survival analyses were conducted. Prognostic genes were identified using Cox and LASSO regression. DEHP risk score models and nomograms were constructed. Immune infiltration was analyzed using ESTIMATE and ssGSEA algorithms. Molecular docking was performed via CB-Dock2. Seventy-five genetic targets linked to DEHP in toxicological databases were identified, and enrichment analyses revealed DEHP-related genes enriched in neurotransmission and hormone signaling pathways. Seven prognostic genes (HTR3A, GRM2, HTR6, THRB, TUBB2B, FOLH1, PGR) correlated with overall survival and histologic grade. The DEHP risk score effectively stratified patients. DEHP-THRB showed strongest binding affinity, suggesting direct toxicological interaction. This study characterizes a computationally derived gene signature associated with DEHP toxicity in UCEC, highlighting their prognostic and immunological significance as potential molecular footprints, while acknowledging that direct exposure inference requires future validation with measured biomonitoring data.</p>","PeriodicalId":14039,"journal":{"name":"International Journal of Environmental Health Research","volume":" ","pages":"1-15"},"PeriodicalIF":1.9,"publicationDate":"2026-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146093041","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
期刊
International Journal of Environmental Health Research
全部 Acc. Chem. Res. ACS Applied Bio Materials ACS Appl. Electron. Mater. ACS Appl. Energy Mater. ACS Appl. Mater. Interfaces ACS Appl. Nano Mater. ACS Appl. Polym. Mater. ACS BIOMATER-SCI ENG ACS Catal. ACS Cent. Sci. ACS Chem. Biol. ACS Chemical Health & Safety ACS Chem. Neurosci. ACS Comb. Sci. ACS Earth Space Chem. ACS Energy Lett. ACS Infect. Dis. ACS Macro Lett. ACS Mater. Lett. ACS Med. Chem. Lett. ACS Nano ACS Omega ACS Photonics ACS Sens. ACS Sustainable Chem. Eng. ACS Synth. Biol. Anal. Chem. BIOCHEMISTRY-US Bioconjugate Chem. BIOMACROMOLECULES Chem. Res. Toxicol. Chem. Rev. Chem. Mater. CRYST GROWTH DES ENERG FUEL Environ. Sci. Technol. Environ. Sci. Technol. Lett. Eur. J. Inorg. Chem. IND ENG CHEM RES Inorg. Chem. J. Agric. Food. Chem. J. Chem. Eng. Data J. Chem. Educ. J. Chem. Inf. Model. J. Chem. Theory Comput. J. Med. Chem. J. Nat. Prod. J PROTEOME RES J. Am. Chem. Soc. LANGMUIR MACROMOLECULES Mol. Pharmaceutics Nano Lett. Org. Lett. ORG PROCESS RES DEV ORGANOMETALLICS J. Org. Chem. J. Phys. Chem. J. Phys. Chem. A J. Phys. Chem. B J. Phys. Chem. C J. Phys. Chem. Lett. Analyst Anal. Methods Biomater. Sci. Catal. Sci. Technol. Chem. Commun. Chem. Soc. Rev. CHEM EDUC RES PRACT CRYSTENGCOMM Dalton Trans. Energy Environ. Sci. ENVIRON SCI-NANO ENVIRON SCI-PROC IMP ENVIRON SCI-WAT RES Faraday Discuss. Food Funct. Green Chem. Inorg. Chem. Front. Integr. Biol. J. Anal. At. Spectrom. J. Mater. Chem. A J. Mater. Chem. B J. Mater. Chem. C Lab Chip Mater. Chem. Front. Mater. Horiz. MEDCHEMCOMM Metallomics Mol. Biosyst. Mol. Syst. Des. Eng. Nanoscale Nanoscale Horiz. Nat. Prod. Rep. New J. Chem. Org. Biomol. Chem. Org. Chem. Front. PHOTOCH PHOTOBIO SCI PCCP Polym. Chem.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:604180095
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1