This paper introduces an innovative approach to modelling boundary conditions for blood flow simulations in arteries with highly complex geometries and multiple outlets. In cases where the arterial cross-section varies significantly, employing analytical models like Windkessel to represent tissue resistance becomes particularly challenging. In this study, we propose a novel approach that combines a porosity model, which induces a pressure drop, with physiological outlet pressures to achieve realistic hemodynamic conditions in blood vessels. The total proportion of blood flow through the perforators was approximately 7.2 % for the BA and 11.6 % for the MCA, while maintaining physiological velocity values in the subsequent branches. The proposed method stands out for its relative simplicity in determining porous body parameters for outlets of varying diameters by quasi-iteratively adjusting two key values of the Power Law model. A major advantage of this approach is its accessibility to non-experts in fluid mechanics, as it does not require complex model reductions to 1D. The study also examines key parameters influencing artery remodelling processes, specifically wall shear stress divergence (WSSD). Furthermore, preliminary histopathological analyses confirm that regions with low WSSD exhibit structural changes in the vessel wall, leading changes similar to intimal hyperplasia. The original data such as DICOM images, artery geometry and domain mesh for the individual representations, together with UDF files for the initial boundary conditions, have been included in the Mendeley database: DOI: 10.17632/5vxtmcwr64.3 and basilar artery model in DOI: 10.17632/ng9mrrn2r7.3.
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