Various uncertainties are widely presented in engineering problems, such as material properties, loads, geometries, etc. Research has indicated that there is a significant relationship between the dispersion of fatigue life and the material properties. Therefore, it is necessary to study the effect of the parameter distribution of the material on the uncertainty of fatigue life. However, there are very few studies involving the distribution of fatigue performance parameters {σf’, εf’} of materials. In this paper, a probability framework of multiaxial fatigue life prediction based on the uncertainty of material parameters {σf’, εf’} was established, which focuses on quantifying the distribution of material parameters {σf’, εf’} based on the Huffman model. Next, based on the Fatemi-Socie (FS) model and the distribution of strain life parameters {σf’, εf’}, the probability field of Δγeq/2-N curves were obtained, and experimental data were distributed around the predicted average life. In addition, a time-dependent multiaxial fatigue reliability analysis method based on the Palmgren-Miner rule and P-Δγeq/2-N was derived, and the reliability curves were obtained under four multiaxial loading cases.