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Effect of high background natural radioactivity on human mitochondrial DNA in Ramsar, the north of Iran 伊朗北部拉姆萨尔地区高本底天然放射性对人类线粒体DNA的影响
Q4 Medicine Pub Date : 2016-01-29 DOI: 10.1504/IJLR.2015.074405
Reza Vazifehmand, S. Saber, Abbas Takavr, Dhuha Ali, Tina Saber, Farnaz Takavar
Radioactivity is known to induce tumours, chromosome lesions, and mini-satellite length mutations, but also effects on the DNA sequence. Ramsar region, in the north of Iran with the highest background of natural radiation (226Ra) in the world, with a densely populated area, offers an opportunity to characterise radiation-associated DNA mutations. We sampled 30 individuals from this area and 15 cases from Tehran as controls. We sequenced their mtDNA and found multiple variations in multiple nucleotide positions in Ramsar inhabitants. 16519 and T > C were the most frequent NPS and variables in our study. In this preliminary investigation, we conclude that an elevated level of natural background radiation in Ramsar region had a significant effect on the control region of mtDNA. We think this is the first report from Ramsar in this field. Moreover, using molecular and biological pathways and study of gene expression to understand the cellular and molecular response of human mtDNA to low-dose radiation exposure is recommended.
已知放射性会诱发肿瘤、染色体损伤和小卫星长度突变,但也会影响DNA序列。拉姆萨尔地区位于伊朗北部,拥有世界上最高的自然辐射背景(226Ra),人口稠密,为描述与辐射相关的DNA突变提供了机会。我们从该地区抽取了30例样本,并从德黑兰抽取了15例作为对照。我们对他们的mtDNA进行了测序,发现拉姆萨尔居民的多个核苷酸位置存在多种变异。16519和t> C是我们研究中最常见的NPS和变量。在本初步调查中,我们得出结论,拉姆萨尔地区自然本底辐射水平的升高对mtDNA控制区有显著影响。我们认为这是拉姆萨尔在该领域的第一份报告。此外,建议使用分子和生物学途径以及基因表达研究来了解人类mtDNA对低剂量辐射的细胞和分子反应。
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引用次数: 0
Determination of natural radionuclides in abattoir wastes and sediments from rivers and streams around selected abattoirs in Southwest Nigeria 测定尼日利亚西南部选定屠宰场周围河流和溪流中屠宰场废物和沉积物中的天然放射性核素
Q4 Medicine Pub Date : 2016-01-29 DOI: 10.1504/ijlr.2015.074408
N. Jibiri, O. M. Isinkaye, Oluwafemi A. Ilori, A. A. Sowunmi
The concentrations of natural radionuclides in abattoir wastes and sediments of streams and rivers around selected abattoirs in Southwestern Nigeria have been measured using gamma-ray spectrometry. In abattoir wastes, the activity concentrations obtained in cow-dung samples are higher than those obtained in blood and bone ash samples. For sediment, the mean activity concentration of 40K, 238U and 232Th obtained is 290.04 ± 156.84, 22.02 ± 4.14 and 50.42 ± 18.90 Bq kg−1, respectively. The absorbed gamma-indoor dose rates and other radiological health indices were calculated in order to assess the radiological hazards associated with the use of the sediments in construction of dwellings. The values obtained were less than the recommended safe and criterion limits by UNSCEAR. It is sufficient to say therefore that sediments from the respective rivers and streams around the abattoir sites are safe and can be used for construction of buildings without undue radiological health concerns.
利用伽马射线能谱法测量了尼日利亚西南部某些屠宰场周围的屠宰场废物和溪流及河流沉积物中天然放射性核素的浓度。在屠宰场废物中,牛粪样品中获得的活性浓度高于血液和骨灰样品中获得的活性浓度。沉积物40K、238U和232Th的平均活度浓度分别为290.04±156.84、22.02±4.14和50.42±18.90 Bq kg−1。计算了吸收的γ -室内剂量率和其他辐射健康指数,以便评估与在住宅建设中使用沉积物有关的辐射危害。所获得的数值低于科委会建议的安全和标准限值。因此,可以说,屠宰场周围各河流和溪流的沉积物是安全的,可以用于建造建筑物,而不会引起不必要的辐射健康问题。
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引用次数: 2
Lack of epithelial-to-mesenchymal transition induction in two bronchial epithelial cell lines after alpha and gamma irradiation 两种支气管上皮细胞系在α和γ照射后缺乏上皮向间质转化的诱导
Q4 Medicine Pub Date : 2016-01-29 DOI: 10.1504/ijlr.2015.074411
A. Acheva, E. Eklund, Elina Lemola, T. Siiskonen, V. Launonen, M. Kämäräinen
The induction of epithelial-to-mesenchymal transition (EMT) in human lung epithelial cell lines was investigated after α-particle and γ-radiation exposures. We applied TGF-β treatment of cells as positive EMT-controls and tested in parallel if radiation has a potentiating effect on the EMT induction. BEAS-2B and HBEC-3KT cells were irradiated with 5.4 MeV α-particles or γ-rays (60Co, 1.13-1.15 Gy/min) with or without of TGF-β. The cells were harvested three days post treatment and the EMT markers vimentin, fibronectin and E-cadherin were analysed by immunofluorescence staining and Western blotting. The TGF-β treatment-induced EMT in both cell lines in the applied concentrations. We could not prove any clear EMT induction with low or moderate doses of α-particles and γ-rays. No significant additive effect with radiation and TGF-β was observed. We suggest that there might be a different mechanism induced by radiation in bronchial cells after radon and medical exposures that does not involve direct EMT changes.
研究了α-粒子和γ-辐射对人肺上皮细胞上皮间质转化(EMT)的诱导作用。我们使用TGF-β处理细胞作为阳性EMT对照,并平行测试辐射是否对EMT诱导有增强作用。用含TGF-β或不含TGF-β的5.4 MeV α-粒子或γ射线(60Co, 1.13-1.15 Gy/min)照射BEAS-2B和hbecc - 3kt细胞。处理3天后收获细胞,免疫荧光染色和Western blotting分析EMT标志物vimentin、纤维连接蛋白和E-cadherin。TGF-β处理在两种细胞系中均诱导EMT。我们不能证明低或中剂量α-粒子和γ射线对EMT有明显的诱导作用。放疗与TGF-β无明显叠加作用。我们认为,在氡和医疗照射后,支气管细胞中可能存在不同的辐射诱导机制,而不涉及直接的EMT变化。
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引用次数: 2
Natural radioactivity and radiological hazard assessment of coal samples collected from Kasimpur thermal power plant, Kasimpur (U.P.), India 印度Kasimpur (upp) Kasimpur热电厂煤样的自然放射性和放射性危害评估
Q4 Medicine Pub Date : 2016-01-29 DOI: 10.1504/ijlr.2015.074412
A. Sharma, R. Sonkawade, Avinash C. Sharma
Low-level gamma ray spectroscopy with a NaI (TI) gamma radiation detector was used for the measurement of activity concentrations of radionuclides 226Ra, 232Th and 40K. Activity concentrations of radium were found to vary from 12 to 39 Bq kg−1, thorium ranged from 15 to 49 Bq kg−1 whereas 40K ranged from 157 to 460 Bq kg−1. Radium equivalent activity has been found to vary from 50.8 to 118 Bq kg−1 and absorbed gamma dose rates varied from 24 to 53.2 nGy h−1 whereas corresponding outdoor annual effective dose found to vary from 0.029 to 0.065 mSv y−1. The calculated values of Hex and Hin range from 0.13 to 0.31 and 0.16 to 0.41 respectively whereas values of gamma and alpha index vary from 0.19 to 0.42 and 0.06 to 0.19 respectively. The values of hazard index are under the action limit.
用低水平伽玛能谱仪和NaI (TI)伽玛射线探测器测量了放射性核素226Ra、232Th和40K的活度浓度。镭的活度浓度在12至39 Bq kg - 1之间变化,钍的活度浓度在15至49 Bq kg - 1之间变化,而40K的活度浓度在157至460 Bq kg - 1之间变化。已发现镭当量活度在50.8至118 Bq kg−1之间变化,吸收的伽马剂量率在24至53.2毫希·h−1之间变化,而相应的室外年有效剂量在0.029至0.065毫希·y−1之间变化。Hex和Hin的计算值分别为0.13 ~ 0.31和0.16 ~ 0.41,gamma和alpha指数的计算值分别为0.19 ~ 0.42和0.06 ~ 0.19。危害指数均在作用限值之内。
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引用次数: 0
The human cancer in high natural background radiation areas 高自然本底辐射地区的人类癌症
Q4 Medicine Pub Date : 2016-01-29 DOI: 10.1504/ijlr.2015.074413
L. Dobrzyński, K. W. Fornalski, L. Feinendegen
The studies of health effects in human populations living in places with high levels of natural background radiation are of crucial importance for understanding the impact of low doses of ionising radiation. The paper reviews some exemplary literature that addresses the likelihood of the radiation-induced cancer in aforementioned regions. It is shown that using Bayesian analysis one can arrive at an essentially different conclusion concerning dose-effect dependence from the one which could be guessed from first glance. The general conclusion is that cancers do not correlate with elevated radiation in regions with high natural background radiation.
对生活在自然本底辐射水平高的地方的人口的健康影响进行研究,对于了解低剂量电离辐射的影响至关重要。本文回顾了一些关于上述地区辐射致癌可能性的典型文献。结果表明,利用贝叶斯分析可以得出与乍一看就能猜到的剂量效应依赖关系有本质不同的结论。总的结论是,在天然本底辐射高的地区,癌症与辐射升高无关。
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引用次数: 5
Activity concentration and annual effective ingestion dose assessment due to natural radionuclides present in cereal samples consumed by inhabitants of India 印度居民食用谷物样品中天然放射性核素的活动浓度和年有效摄入剂量评估
Q4 Medicine Pub Date : 2016-01-29 DOI: 10.1504/IJLR.2015.074414
R. Kumari, K. Kant, Maneesha Garg, Rashi Gupta, R. Sonkawade, S. Chakarvarti
In the present study, activity concentration and annual effective ingestion dose assessment was carried out in cereal samples using gamma spectrometry. In the studied samples the activity of 226Ra, 238U, 232Th, and 40K varied from 10.25±0.94 Bq/kg to 29.13±0.69 Bq/kg, 7.04±0.13 Bq/kg to 20.08±1.32 Bq/kg, 22.20±2.46 Bq/kg to 58.21±1.15 Bq/kg and 1158.4±26.05Bq/kg to 1962.2±18.17 Bq/kg with an average value of 20.06±4.82 Bq/kg, 13.08±1.31 Bq/kg, 41.53±3.77 Bq/kg, and 1639±75.55 Bq/kg respectively. The average value of annual effective ingestion dose from ingested food was 0.62±0.08 mSv/y, 0.07±0.006 mSv/y, 1.20±0.11 mSv/y, and 1.28±0.06 mSv/y from 226Ra, 238U, 232Th, and 40K, respectively. The average value of total ingestion dose and cancer risk was found to be 3.18±0.14 mSv/y and (79.5±3.55) × 10−4 respectively.
在本研究中,利用伽马能谱法对谷物样品进行了活性浓度和年有效摄入剂量的评估。研究样品中226Ra、238U、232Th和40K的活性变化范围为10.25±0.94 Bq/kg ~ 29.13±0.69 Bq/kg、7.04±0.13 Bq/kg ~ 20.08±1.32 Bq/kg、22.20±2.46 Bq/kg ~ 58.21±1.15 Bq/kg和1158.4±26.05Bq/kg ~ 1962.2±18.17 Bq/kg,平均值分别为20.06±4.82 Bq/kg、13.08±1.31 Bq/kg、41.53±3.77 Bq/kg和1639±75.55 Bq/kg。226Ra、238U、232Th和40K的年有效摄入剂量平均值分别为0.62±0.08 mSv/y、0.07±0.006 mSv/y、1.20±0.11 mSv/y和1.28±0.06 mSv/y。总摄入剂量平均值为3.18±0.14 mSv/y,致癌风险平均值为(79.5±3.55)× 10−4。
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引用次数: 4
Assessment of the possible radiological hazard caused from marble and granite tails commercially available in Egypt 对埃及市售大理石和花岗岩尾石可能造成的放射性危害进行评估
Q4 Medicine Pub Date : 2016-01-01 DOI: 10.1504/IJLR.2016.10002420
A. Mostafa
This paper reports the natural radioactivity and possible radiological hazards in different types of local and imported marble and granite tiles used as covering building materials in Egypt. Gamma-ray spectrometry was used to estimate the 226Ra, 232Th and 40K activity concentrations. The obtained values were found in the ranges 15-73, 29-203, and 50-253 Bq kg−1 in marbles and 23-179, 78-317, 113-1207 Bq kg−1 in granites for 226Ra, 232Th and 40K, respectively. Using indirect methods radon exhalation rates were calculated, the obtained values varied from 2.1 to 9.7 and from 3-23.9 Bq m−2 h−1 for marble and granite samples, respectively. Radon concentrations in the room caused by marble and granite samples were also estimated. Under normal ventilation (0.5 h−1), the obtained values were below reference level (100 Bq m−3) recommended by World Health Organization. Most values of external annual dose and annual doses due to the indoor radon exposure (ERn) were within recommended.
本文报道了埃及用于建筑覆盖材料的不同类型的本地和进口大理石和花岗岩砖的天然放射性和可能的放射性危害。用伽马能谱法测定了226Ra、232Th和40K的活度浓度。在226Ra、232Th和40K中,大理岩的Bq - kg -1分别为15 ~ 73,29 ~ 203,50 ~ 253bq - kg -1,花岗岩的Bq - kg -1分别为23 ~ 179,78 ~ 317,113 ~ 1207。采用间接方法计算氡的呼出率,得到的数值分别为2.1 ~ 9.7 Bq m−2 h−1和3 ~ 23.9 Bq m−2 h−1。还估计了大理石和花岗岩样品引起的室内氡浓度。在正常通风(0.5 h−1)下,获得的数值低于世界卫生组织推荐的参考水平(100 Bq m−3)。大多数外部年剂量和室内氡暴露(ERn)引起的年剂量值在推荐范围内。
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引用次数: 0
Studies of radioactive contaminations and heavy metal contents in cosmetics 化妆品中放射性污染物和重金属含量的研究
Q4 Medicine Pub Date : 2016-01-01 DOI: 10.1504/IJLR.2016.10002356
H. Abdel-ghany, F. Ragab
Measurement of radioactivity in cosmetics such as face powders and eye liner (kohl) has not been reported so far. Herein gamma ray spectrometry and CR-39 solid state nuclear track detector have been used to investigate six cosmetics of different brands. The results have demonstrate that the average values of specific activities of 238U, 232Th and 40K were 12.66±2.96, 14.58±8.83 and 269±120 Bqkg−1, respectively. Also the average radon exhalation rate was 0.21±0.04 Bqm−2h−1. The calculated radium-equivalents were lower than recommended value (370 Bqkg−1). The absorbed dose rates due to the natural radioactivity of the investigated samples ranged from 6.83±2.6 to 99.5±51 nGyh−1. Also, X-ray fluorescence spectrometry studies showed that the concentrations of the heavy Mo, Sr, Pb, Zn, Cu, Ni, Fe, Mn, Rb, As, Zr and Cr were 4±0.96, 26.93±12.24, 110135±109973, 672.98±433, 1001±722, 318±145, 3847±790, 60±25, 24.71±13, 9002±4210, 24.71±18 and 153±72 ppm, respectively.
到目前为止,对化妆品(如粉饼和眼线笔)的放射性测量还没有报道。本文采用伽马能谱法和CR-39固体核径迹探测器对6种不同品牌的化妆品进行了研究。结果表明,238U、232Th和40K的比活度平均值分别为12.66±2.96、14.58±8.83和269±120 Bqkg−1。氡平均呼出率为0.21±0.04 Bqm−2h−1。计算出的镭当量低于推荐值(370 Bqkg−1)。所研究样品的自然放射性吸收剂量率范围为6.83±2.6 ~ 99.5±51 nGyh−1。x射线荧光光谱研究表明,重Mo、Sr、Pb、Zn、Cu、Ni、Fe、Mn、Rb、As、Zr和Cr的浓度分别为4±0.96、26.93±12.24、110135±109973、672.98±433、1001±722、318±145、3847±790、60±25、24.71±13、9002±4210、24.71±18和153±72 ppm。
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引用次数: 0
Determinations of soil radioactivity, indoor radon concentration levels and their correlation in Oke-Ogun area, Southwestern Nigeria 尼日利亚西南部奥克-奥贡地区土壤放射性、室内氡浓度水平及其相关性的测定
Q4 Medicine Pub Date : 2016-01-01 DOI: 10.1504/IJLR.2016.10002362
A. Ademola, R. Obed
Indoor radon concentration measurements in 116 rooms and gamma activity measurements in the soil samples around the rooms were carried out in Oke-Ogun area (Southwestern, Nigeria). The mean activity concentrations of 40K, 232Th, and 238U in the soil were 3±5, 25±7 and 212±99 Bqkg−1, respectively. The mean absorbed dose rate (D) and the effective dose estimated were 44±8 nGy h−1 and 45±8 μSv y−1, respectively. Radon concentrations in the rooms varied from 148 Bqm−3 to 627 Bqm−3 with mean of 282±99 Bqm−3. The estimated mean annual effective dose is 7±2 mSv y−1. It is therefore advisable for the inhabitants of the study area to ventilate their houses regularly, to reduce the possible risk of contracting lung cancer. Radon concentration in the rooms surveyed show a good correlation (R² = 0.702) with 238U/226Ra activity in soil samples.
在奥克-奥贡地区(尼日利亚西南部)对116个房间的室内氡浓度进行了测量,并对房间周围土壤样品进行了伽马活度测量。土壤中40K、232Th和238U的平均活性浓度分别为3±5、25±7和212±99 Bqkg−1。估计的平均吸收剂量率(D)和有效剂量分别为44±8 nGy h−1和45±8 μSv y−1。室内氡浓度为148 ~ 627 Bqm−3,平均值为282±99 Bqm−3。估计年平均有效剂量为7±2毫西弗y - 1。因此,建议研究地区的居民定期给房屋通风,以减少患肺癌的可能风险。室内氡浓度与土壤样品中238U/226Ra活性呈良好的相关关系(R²= 0.702)。
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引用次数: 0
Radioactivity concentrations and dose assessment for agricultural soil samples around the Jordanian petroleum refinery in Zarqa, Jordan 约旦扎尔卡约旦炼油厂周围农业土壤样品的放射性浓度和剂量评估
Q4 Medicine Pub Date : 2016-01-01 DOI: 10.1504/IJLR.2016.081461
F. Afaneh, Mashour Al-Momani, J. Al-Jundi, A. Aldrabee, Hassan K. Juwhari
The activity concentrations of the natural radionuclides (238U, 232Th, 40K) in the agricultural soils around the Jordanian petroleum refinery in Zarqa city, Jordan, were investigated. The soil samples were collected from three different agricultural regions (X, Y and Z). The 232Th activity concentration was found to be too low in all samples. The average activity concentrations in Bq/kg were found to be: 40.1±1.6 for 238U and 372.6±11.9 for 40K in X-site, 38.3±1.9 for 238U and 486.4±15.0 for 40K in Y-site, and 45.4±1.3 for 238U and 313.3±11.1 for 40K in Z-site. Our findings are within the worldwide average values (UNSCEAR, 2000). The absorbed dose rates were calculated and found to be in the range of 20.86-47.62 nGy/h with an overall average value of 34.66 nGy/h. The average outdoor annual effective dose equivalent was estimated to be 41.13 ± 11.64 μSvy−1 which is below the world average of 70 μSvy−1.
对约旦扎尔卡市约旦炼油厂周围农业土壤中天然放射性核素(238U、232Th、40K)的活度浓度进行了调查。从X、Y、Z三个不同的农业区采集土壤样品,发现所有样品的232Th活性浓度都过低。x位点238U和40K的平均活性浓度分别为40.1±1.6和372.6±11.9,y位点238U和40K的平均活性浓度分别为38.3±1.9和486.4±15.0,z位点238U和40K的平均活性浓度分别为45.4±1.3和313.3±11.1。我们的研究结果在世界平均值之内(UNSCEAR, 2000)。计算吸收剂量率范围为20.86 ~ 47.62 nGy/h,总体平均值为34.66 nGy/h。室外年平均有效剂量当量为41.13±11.64 μSvy−1,低于70 μSvy−1的世界平均水平。
{"title":"Radioactivity concentrations and dose assessment for agricultural soil samples around the Jordanian petroleum refinery in Zarqa, Jordan","authors":"F. Afaneh, Mashour Al-Momani, J. Al-Jundi, A. Aldrabee, Hassan K. Juwhari","doi":"10.1504/IJLR.2016.081461","DOIUrl":"https://doi.org/10.1504/IJLR.2016.081461","url":null,"abstract":"The activity concentrations of the natural radionuclides (238U, 232Th, 40K) in the agricultural soils around the Jordanian petroleum refinery in Zarqa city, Jordan, were investigated. The soil samples were collected from three different agricultural regions (X, Y and Z). The 232Th activity concentration was found to be too low in all samples. The average activity concentrations in Bq/kg were found to be: 40.1±1.6 for 238U and 372.6±11.9 for 40K in X-site, 38.3±1.9 for 238U and 486.4±15.0 for 40K in Y-site, and 45.4±1.3 for 238U and 313.3±11.1 for 40K in Z-site. Our findings are within the worldwide average values (UNSCEAR, 2000). The absorbed dose rates were calculated and found to be in the range of 20.86-47.62 nGy/h with an overall average value of 34.66 nGy/h. The average outdoor annual effective dose equivalent was estimated to be 41.13 ± 11.64 μSvy−1 which is below the world average of 70 μSvy−1.","PeriodicalId":14141,"journal":{"name":"International Journal of Low Radiation","volume":"10 1","pages":"234"},"PeriodicalIF":0.0,"publicationDate":"2016-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1504/IJLR.2016.081461","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"66669502","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
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International Journal of Low Radiation
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