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Transcriptional expression of H2B, CTP synthase and PLK3 genes in whole blood exposed to 60 Co gamma radiation 60co辐照下全血H2B、CTP合成酶和PLK3基因的转录表达
Q4 Medicine Pub Date : 2011-06-13 DOI: 10.1504/IJLR.2011.040649
V. Jain, B. Das, M. Seshadri
Ionising radiation induces complex molecular responses in human cells resulting in changes at mRNA and protein expression. Limited data is available on the transcriptional status of functional genes in response to ionising radiation using peripheral blood mononuclear cells (PBMCs). In the present study, transcriptional profiles of Histone 2B , CTP synthase and PLK3 were studied. Blood samples were collected from ten random healthy males with informed consent. Whole blood irradiation was done at four different dose groups (0.3, 0.6, 1.0 and 2.0 Gy) at a dose rate of 0.68 Gy/minute. PBMCs were separated immediately as well as 4 hours post-irradiation. Total RNA was isolated, transcribed to cDNA and real-time quantitative PCR was performed. Our results revealed a dose-dependent significant upregulation at H2B and CTP synthase at 4 hours post-irradiation. At PLK3 significant upregulation was observed at 2.0 Gy ( P = 0.007). In conclusion, these genes can be used for population monitoring programme.
电离辐射在人体细胞中诱导复杂的分子反应,导致mRNA和蛋白质表达的变化。利用外周血单核细胞(PBMCs)应答电离辐射的功能基因转录状态的数据有限。本研究研究了组蛋白2B、CTP合成酶和PLK3的转录谱。在知情同意的情况下,随机抽取10名健康男性的血液样本。全血辐照分为0.3、0.6、1.0、2.0 Gy 4个剂量组,剂量率0.68 Gy/min。在照射后4小时和立即分离pbmc。提取总RNA,转录成cDNA,进行实时定量PCR。我们的研究结果显示,辐照后4小时H2B和CTP合成酶出现剂量依赖性的显著上调。2.0 Gy时PLK3显著上调(P = 0.007)。总之,这些基因可用于种群监测方案。
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引用次数: 8
Special effects of low doses and lifespan of irradiated daphnids 低剂量辐照水蚤的特殊效应及寿命
Q4 Medicine Pub Date : 2011-06-13 DOI: 10.1504/IJLR.2011.040647
I. B. Bychkovskaya, E. Sarapultseva
Specific species-unspecific effects of low-radiation doses were studied. These effects are fundamentally different from stochastic effects. They have a mass character and full appearance at low doses for the species. The characteristic manifestation of the studied type of effect is a steady increase in the probability of cell death. Earlier in the model experiments on the crustacean Daphnia magna it was shown that the studied type of damage at low doses (0.1, 1 and 20 Gy, LD 50/30 = 100 Gy) can develop a dose-independent increased mortality of irradiated daphnids. The present study shows that the studied type of effect can lead to reduced life expectancy of daphnids at a lowest dose of 0.1 Gy. Owing to the fact that the studied effect is observed at organism level, it is assumed that it could affect the life expectancy in mammals (including humans) even at relatively low doses of radiation.
研究了低辐射剂量对特定物种的非特异性影响。这些效应与随机效应根本不同。它们在低剂量下具有质量特征和完整的外观。所研究的效应类型的特征表现是细胞死亡概率的稳步增加。早期对大水蚤的模型实验表明,低剂量(0.1、1和20 Gy, LD 50/30 = 100 Gy)所研究的损伤类型可以导致水蚤死亡率的剂量无关性增加。目前的研究表明,所研究的这种效应在最低0.1 Gy的剂量下可导致水蚤的预期寿命缩短。由于所研究的影响是在生物体水平上观察到的,因此假定即使在相对较低剂量的辐射下,它也可能影响哺乳动物(包括人类)的预期寿命。
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引用次数: 4
Caffeine treatment enhances low dose γ-irradiation- induced chromatid-type aberrations in human leukaemia cells, but not in human normal fibroblast cells in culture 咖啡因处理增强了低剂量γ辐照诱导的人白血病细胞染色单体型畸变,但对培养的人正常成纤维细胞没有影响
Q4 Medicine Pub Date : 2011-01-01 DOI: 10.1504/IJLR.2011.047176
M. N. Jha, J. Bedford, S. Jha, K. Prasad
We investigated the effect of caffeine on low dose γ -radiationinduced chromosomal damage in human T-cell leukaemia cells (Jurkat T-cells) and two normal human fibroblast cell lines (AG1522 and GM2149). Low doses of gamma-radiation were found to increase the levels of chromatid gaps and breaks in a dose-dependent manner in both normal and cancer cells; however, cancer cells appeared to be more sensitive than the normal cells. Caffeine treatment before radiation exposure significantly increased the levels of chromatid gaps and breaks in Jurkat T-cells at all radiation doses, but it did not increase the level of these aberrations in normal cells. The mechanisms of this differential effect of caffeine in cancer cells and normal cells are unknown; however, G2-delay allows more time for rejoining of chromosome breakage to occur, then elimination of this delay by caffeine in tumour cells, not in normal cells might account for difference.
我们研究了咖啡因对低剂量γ辐射诱导的人t细胞白血病细胞(Jurkat t细胞)和两种正常人成纤维细胞系(AG1522和GM2149)染色体损伤的影响。发现低剂量的伽马辐射会以剂量依赖的方式增加正常细胞和癌细胞中染色单体间隙和断裂的水平;然而,癌细胞似乎比正常细胞更敏感。辐射暴露前的咖啡因处理在所有辐射剂量下都显著增加了Jurkat t细胞中染色单体间隙和断裂的水平,但没有增加正常细胞中这些畸变的水平。咖啡因对癌细胞和正常细胞的不同作用机制尚不清楚;然而,g2延迟允许更多的时间来重新连接染色体断裂发生,然后咖啡因消除这种延迟在肿瘤细胞中,而不是在正常细胞中可能解释差异。
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引用次数: 1
Dosimetry analysis of two new design 103 Pd interstitial brachytherapy sources 两种新设计的103 Pd间质性近距离放射治疗源的剂量学分析
Q4 Medicine Pub Date : 2011-01-01 DOI: 10.1504/IJLR.2011.047177
P. Saidi, M. Sadeghi, A. Shirazi, S. Mahdavi, M. Mirzaii
With increased demand for low 103 Pd (palladium) seed sources, to treat prostate and eye cancers, new sources have been designed and introduced. This paper presents the two new palladium brachytherapy sources, IR03- 103 Pd and IR04- 103 Pd that have been developed at Agricultural, Medical & Industrial Research School . The dosimetric parameters, such as the dose rate constant Λ , the radial dose function g ( r ) and the anisotropy function F ( r , θ ), around the sources have been characterised using Version 5 Monte Carlo radiation transport code in accordance with the update AAPM Task Group No. 43 Report (TG-43U1). The results indicated the dose rate constant of 0.689 ± 0.02 and 0.667 ± 0.02 cGy h -1 U -1 for the IR03- 103 Pd and IR04- 103 Pd sources, respectively, which are in acceptable agreement with other commercial seeds. The calculated results were compared with published results for those of other source manufacturers. However, they show an acceptable dose distribution, using for clinical applications is pending experimental dosimetry.
随着对低103 Pd(钯)种子源的需求增加,用于治疗前列腺癌和眼癌,新的来源已被设计和引入。本文介绍了农业、医学和工业研究学院开发的两种新型钯近距离治疗源IR03- 103pd和IR04- 103pd。辐射源周围的剂量学参数,如剂量率常数Λ、径向剂量函数g (r)和各向异性函数F (r, θ),已根据最新的AAPM工作组第43号报告(TG-43U1),使用第5版蒙特卡罗辐射输运代码进行了表征。结果表明,IR03- 103 Pd和IR04- 103 Pd源的剂量率常数分别为0.689±0.02和0.667±0.02 cGy h -1 U -1,与其他商品种子的剂量率常数基本一致。计算结果与公布的其他来源制造商的结果进行了比较。然而,它们显示出可接受的剂量分布,用于临床应用尚待实验剂量测定。
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引用次数: 0
A chronic very low dose of gamma-rays alters cell adhesion 长期极低剂量的伽马射线会改变细胞粘附
Q4 Medicine Pub Date : 2011-01-01 DOI: 10.1504/IJLR.2011.047185
L. Lacoste-Collin, S. Jozan, V. Pereda, M. Courtade-Saïdi
The biological effects of very low doses of ionising radiation are difficult to assess. We previously observed a delay of death by lymphoma in two different mouse strains continuously irradiated ( γ -rays) with a dose rate of 10 cGy year −1 . Cellular mechanisms likely to lead to slowing tumour growth were explored. Human lymphoid and epithelial cell lines (HL60 and MCF7) were irradiated in vitro at very low dose rate of 4 cGy month −1 . Proliferation was not modified in HL60 and MCF7 cells. However, irradiated MCF7 adherent cells showed a lower cell attachment to support partly related to a slight decrease in expression levels of α6 and β4 integrins. We also observed a transient adaptive response during at least two weeks after the beginning of the irradiation in both cell lines. These results demonstrate the ability of tiny amounts of gamma-irradiation to alter cell attachment to support and to induce an adaptive response.
极低剂量电离辐射的生物效应难以评估。我们之前观察到,在两种不同的小鼠品系中,以10 cGy年−1的剂量率连续照射(γ射线)可延迟死于淋巴瘤。研究人员还探索了可能导致肿瘤生长减缓的细胞机制。人淋巴细胞和上皮细胞系(HL60和MCF7)在体外以4 cGy月−1的极低剂量率照射。HL60和MCF7细胞的增殖未受影响。然而,辐照后MCF7贴壁细胞表现出较低的细胞粘附力,这与α6和β4整合素的表达水平略有下降有关。我们还观察到两种细胞系在辐照开始后至少两周内出现了短暂的适应性反应。这些结果表明,少量的伽马辐射能够改变细胞的附着,以支持和诱导适应性反应。
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引用次数: 3
The comparison of CD4/CD8 ratio among high and ordinary background radiation areas in Ramsar, Iran 伊朗拉姆萨尔地区高、普通本底辐射区CD4/CD8比值比较
Q4 Medicine Pub Date : 2011-01-01 DOI: 10.1504/IJLR.2011.046531
S. Borzoueisileh, A. Monfared, S. Abediankenari, A. Mostafazadeh, M. Khosravifarsani, M. Amiri, F. Elahimanesh
The High Natural Background Radiation Area (HNBRA) of Ramsar has been the subject of concern in the last 40 years for a high level of radiation measured in some spots as high as 260 mSv per year. Studies of health status of Ramsar inhabitants did not show significant increase in the frequency of cancer. In this study, some aspects of the immune surveillance in the HNBRA residents of Ramsar were investigated. Our results showed that the CD4+ and CD8+ percentage in residents of HNBRA was higher compared to the Ordinary Natural Background Radiation Area (ONBRA) inhabitants. However, the difference between CD4+ also CD8+ cells count and CD4/CD8 ratio in two areas was not significant statistically. These findings may indicate that the immune systems of these people are adapted but more studies to compare the function of immune systems between two groups become essential.
拉姆萨尔的高自然本底辐射区(HNBRA)在过去40年一直备受关注,有些地方的辐射水平高达每年260毫西弗。对拉姆萨尔居民健康状况的研究没有显示癌症发病率显著增加。本研究对拉姆萨尔地区HNBRA居民免疫监测的某些方面进行了调查。结果表明,与普通自然本底辐射区(ONBRA)居民相比,HNBRA居民CD4+和CD8+百分比较高。但两区CD4+、CD8+细胞计数及CD4/CD8比值差异无统计学意义。这些发现可能表明,这些人的免疫系统是适应的,但更多的研究来比较两组人之间的免疫系统功能是必要的。
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引用次数: 12
A simple radon chamber for use with soil gas for calibration of radon measuring devices and instruments 一种简单的氡室,用于土壤气体,用于校准氡测量装置和仪器
Q4 Medicine Pub Date : 2011-01-01 DOI: 10.1504/IJLR.2011.047183
D. Al-Azmi, N. Karunakara
A simple and easy to use radon calibration chamber of volume of 216 litres was designed and constructed for applications in calibration of radon measuring devices and for research studies. The main advantage of this chamber is that instead of using 226 Ra source to generate the 222 Rn inside the chamber, soil gas is utilised as a source of 222 Rn. Soil gas is drawn from the soil using a pump to fill the chamber in order to obtain radon with high concentrations inside the chamber. The advantage of this technique is that the desired radon concentration (ranging from few Bq/m 3 to about kBq/m 3 ) can be attained easily and fast at any time by filling the chamber with different volumes of soil gas. After demonstrating the usefulness of the technique, calibration experiments were carried out for radon measuring devices (charcoal canisters and scintillation cell) using the calibration chamber constructed in the present study.
设计和制造了一个体积为216升的简单易用的氡校准室,用于氡测量装置的校准和研究。该室的主要优点是不使用226 Ra源在室内产生222 Rn,而是利用土壤气体作为222 Rn源。用泵从土壤中抽取土壤气体,填满腔室,以便在腔室内获得高浓度的氡。该技术的优点是,通过向室内填充不同体积的土壤气体,可以随时轻松快速地获得所需的氡浓度(范围从几Bq/ m3到大约kBq/ m3)。在证明了该技术的实用性之后,利用本研究构建的校准室对氡测量装置(木炭罐和闪烁池)进行了校准实验。
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引用次数: 6
Low doses of γ-radiation induce consistent protein expression changes in human leukocytes 低剂量γ-辐射诱导人白细胞一致的蛋白表达变化
Q4 Medicine Pub Date : 2011-01-01 DOI: 10.1504/IJLR.2011.047188
Sara Skiöld, S. Becker, U. Hellman, G. Auer, I. Näslund, M. Harms‐Ringdahl, S. Haghdoost
Twenty percent of cancer patients experience adverse effects after radiotherapy. The therapeutic doses are adjusted to the most sensitive individuals, resulting in a suboptimal dose for many patien ...
20%的癌症患者在接受放射治疗后会出现不良反应。治疗剂量是根据最敏感的个体调整的,导致许多病人的剂量不是最佳的。
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引用次数: 6
Medicinal fungus Ganoderma lucidum protects cellular DNA in mice exposed to whole-body gamma radiation 药用真菌灵芝保护暴露于全身伽马辐射的小鼠的细胞DNA
Q4 Medicine Pub Date : 2011-01-01 DOI: 10.1504/IJLR.2011.046168
F. Martin, C. Nair
Ganoderma lucidum is a medicinal fungus with a variety of biological activities and is used for the treatment of various diseases, including cancers. The present work is focused on the radioprotective property of G. lucidum in Swiss albino mice. Whole-body exposure of the mice to gamma radiation results in damage to cellular DNA in various tissues, such as brain, bone marrow, blood and intestine, and prior administration of a hydroal-coholic extract of G. lucidum prevented radiation-induced DNA damage. Administration of the extract prior to whole-body exposure to a lethal dose of gamma radiation gave survival advantage to mice. Also, there was considerable protection from radiation-induced loss of body weight in animals administered with the extract. The results are suggestive of the radioprotective activity of G. lucidum Extract (GLE) in mammalian organism.
灵芝是一种具有多种生物活性的药用真菌,用于治疗包括癌症在内的多种疾病。本文主要研究了灵芝对瑞士白化小鼠的辐射防护作用。将小鼠全身暴露在伽马辐射下会导致不同组织的细胞DNA受损,如大脑、骨髓、血液和肠道,而事先服用灵芝水乙醇提取物可防止辐射引起的DNA损伤。在小鼠全身暴露于致死剂量的伽马辐射之前服用这种提取物,对小鼠具有生存优势。此外,使用该提取物的动物对辐射引起的体重下降有相当大的保护作用。结果提示灵芝提取物(GLE)对哺乳动物机体具有辐射防护作用。
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引用次数: 4
The possibility of determining of anomalies and pathologies in the offspring of liquidators of Chernobyl accident by non–radiation factors 用非辐射因素确定切尔诺贝利事故清理者后代异常和病理的可能性
Q4 Medicine Pub Date : 2011-01-01 DOI: 10.1504/IJLR.2011.046529
A. N. Koterov, A. Biryukov
Hereditary effects of radiation on people are not revealed and estimations for humans have been carried out by extrapolation from mutagenesis of irradiated mice (UNSCEAR). Nevertheless, in Russia, Ukraine and Belarus disturbance and pathologies are found in the children of liquidators of the accident at the Chernobyl atomic power station. Authors connect effects only with irradiation (basically in low doses) though there were also other factors. So, the psychogenic stress leads to genomic and chromosomal damages and strengthens the mutagens. For the offspring of parents with psychoemotional stress, depression, etc. the set of alterations and diseases is registered. For liquidators probably there is also the influence of other non–radiation factors. The conclusion is made that effects on the children of liquidators have mainly not a radiation cause. Families of liquidators were in a stress (together with effects of other agents on fathers) and could give birth to less healthy children.
辐射对人类的遗传影响尚未揭示,对人类的估计是通过辐照小鼠诱变的外推法进行的(UNSCEAR)。然而,在俄罗斯、乌克兰和白俄罗斯,在切尔诺贝利核电站事故清理者的子女中发现了骚乱和病症。虽然也有其他因素,但作者们只将影响与辐照(基本上是低剂量)联系起来。因此,心因性应激导致基因组和染色体损伤,并加强了诱变因子。对于父母有心理情绪压力、抑郁等的后代,登记了一系列的变化和疾病。对于清算人来说,可能还有其他非辐射因素的影响。结论是,对清算人子女的影响主要不是辐射原因。清算人的家庭处于压力之中(加上其他代理人对父亲的影响),可能生下不太健康的孩子。
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引用次数: 7
期刊
International Journal of Low Radiation
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