Pub Date : 2014-05-23DOI: 10.1504/IJLR.2014.060913
R. Tripathi, V. Jha
Low-grade uranium ore is mined and processed in India since the early 1970s. To adhere to the regulatory compliance monitoring of external gamma level, radon and long-lived alpha activity of ore dust is carried out in uranium mines. Apart from this, surface contamination is also monitored in radiologically important areas of ore processing plant. Exposure of occupational workers is evaluated based on the results of area and personal monitoring. Monitoring of radon and external gamma level is carried out in the vicinity of tailings pond and away. Samples from surface water, groundwater and soil are collected from the environment adjoining the facilities. Results reveal that the exposure of occupational workers is well below the annual average dose limit of 20 mSv as prescribed by the Atomic Energy Regulatory Board (AERB). Results further reflect that the discharges of process waste at tailings pond have not modified the pre-existing radiological status of the environment.
{"title":"Radiological safety and environmental monitoring aspects of mining and processing of uranium ore at Jaduguda, India","authors":"R. Tripathi, V. Jha","doi":"10.1504/IJLR.2014.060913","DOIUrl":"https://doi.org/10.1504/IJLR.2014.060913","url":null,"abstract":"Low-grade uranium ore is mined and processed in India since the early 1970s. To adhere to the regulatory compliance monitoring of external gamma level, radon and long-lived alpha activity of ore dust is carried out in uranium mines. Apart from this, surface contamination is also monitored in radiologically important areas of ore processing plant. Exposure of occupational workers is evaluated based on the results of area and personal monitoring. Monitoring of radon and external gamma level is carried out in the vicinity of tailings pond and away. Samples from surface water, groundwater and soil are collected from the environment adjoining the facilities. Results reveal that the exposure of occupational workers is well below the annual average dose limit of 20 mSv as prescribed by the Atomic Energy Regulatory Board (AERB). Results further reflect that the discharges of process waste at tailings pond have not modified the pre-existing radiological status of the environment.","PeriodicalId":14141,"journal":{"name":"International Journal of Low Radiation","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2014-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1504/IJLR.2014.060913","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"66668693","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2014-05-23DOI: 10.1504/IJLR.2014.060909
D. D. Jayanthi, C. Maniyan, S. Perumal
The present study was carried out to evaluate the activity concentration of radionuclides and the annual effective dose received by the residents of south-west coast of Tamil Nadu, India, due to the consumption of typical South Indian meal. Food samples were collected and analysed by means of gamma spectrometry to measure the activity concentration of 228Ra, 40K, 232Th and 238U. The daily intake of 228Ra, 40K, 232Th and 238U activity ranged from 1.34 to 2.98 Bq kg–1, 27.7 to 88.7 Bq kg–1, 5.4 to 11.3 Bq kg–1 and 2.05 to 4.94 Bq kg–1, respectively. Among the intake of radionuclides, the highest consumption is that of 40K. The annual effective dose to individuals from the consumption of South Indian food was estimated on the basis of the measured radionuclide contents in the food. The annual effective dose received by the individuals ranged between 0.79 and 1.73 mSv.
{"title":"Measurement of activity concentration of radionuclides and the committed annual effective dose due to the consumption of typical South Indian meal","authors":"D. D. Jayanthi, C. Maniyan, S. Perumal","doi":"10.1504/IJLR.2014.060909","DOIUrl":"https://doi.org/10.1504/IJLR.2014.060909","url":null,"abstract":"The present study was carried out to evaluate the activity concentration of radionuclides and the annual effective dose received by the residents of south-west coast of Tamil Nadu, India, due to the consumption of typical South Indian meal. Food samples were collected and analysed by means of gamma spectrometry to measure the activity concentration of 228Ra, 40K, 232Th and 238U. The daily intake of 228Ra, 40K, 232Th and 238U activity ranged from 1.34 to 2.98 Bq kg–1, 27.7 to 88.7 Bq kg–1, 5.4 to 11.3 Bq kg–1 and 2.05 to 4.94 Bq kg–1, respectively. Among the intake of radionuclides, the highest consumption is that of 40K. The annual effective dose to individuals from the consumption of South Indian food was estimated on the basis of the measured radionuclide contents in the food. The annual effective dose received by the individuals ranged between 0.79 and 1.73 mSv.","PeriodicalId":14141,"journal":{"name":"International Journal of Low Radiation","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2014-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1504/IJLR.2014.060909","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"66669103","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2014-05-23DOI: 10.1504/IJLR.2014.060911
K. Mezhoud, Amina Sakly, H. B. Cheikh, M. Saidi, M. Edery
Radiology is an essential technology in medicine and is used for organ diagnosis, radio-tracing and radiotherapy. The risks for the radiobiology workers have not been assessed sufficiently because measuring instruments fail to detect very low doses. This paper presents an investigation on the potential risks for radiobiology workers, due to the occupational exposure to low doses of irradiation. In this respect we used plasma samples from 16 subjects who were supposed to receive very low dose of irradiation in a longer time period. We used chromosomal aberrations, means of oxidative stress measurement and combined proteomics and bioinformatics in order to elucidate risks of such exposure. We found significant chromosome aberrations in lymphocytes and the increase of oxidative stress biomarkers in plasma. In addition, the proteomic analysis shows differentially regulated proteins from which three were verified by ELISA tests. This proteomic analysis picks out some interesting proteins that may belong to biomarkers panel of radiation exposure.
{"title":"Radiobiology worker risk assessment using stress indicators and proteomics","authors":"K. Mezhoud, Amina Sakly, H. B. Cheikh, M. Saidi, M. Edery","doi":"10.1504/IJLR.2014.060911","DOIUrl":"https://doi.org/10.1504/IJLR.2014.060911","url":null,"abstract":"Radiology is an essential technology in medicine and is used for organ diagnosis, radio-tracing and radiotherapy. The risks for the radiobiology workers have not been assessed sufficiently because measuring instruments fail to detect very low doses. This paper presents an investigation on the potential risks for radiobiology workers, due to the occupational exposure to low doses of irradiation. In this respect we used plasma samples from 16 subjects who were supposed to receive very low dose of irradiation in a longer time period. We used chromosomal aberrations, means of oxidative stress measurement and combined proteomics and bioinformatics in order to elucidate risks of such exposure. We found significant chromosome aberrations in lymphocytes and the increase of oxidative stress biomarkers in plasma. In addition, the proteomic analysis shows differentially regulated proteins from which three were verified by ELISA tests. This proteomic analysis picks out some interesting proteins that may belong to biomarkers panel of radiation exposure.","PeriodicalId":14141,"journal":{"name":"International Journal of Low Radiation","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2014-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1504/IJLR.2014.060911","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"66668647","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2014-05-23DOI: 10.1504/IJLR.2014.060912
N. Jain
Health and environmental impact of tritium released from fusion reactor technology may end up as a worldwide problem in the final analysis. Pregnant Swiss albino mice were irradiated with 11.1 kBq ml–1 tritiated drinking water. The young ones born to them were maintained on tritiated water (HTO) at the same dose level and in adulthood, when tested in a maze showed an apparent increased learned behaviour over the controls, though statistically not significant. Similar results have been obtained when mice were acutely irradiated at a dose 185 kBq gm–1 body weight of tritiated water. Histologically, in the cerebellar tissue excised from mice brain after the ethology experiments, there was a depopulation of granule cells and the Purkinje cells appeared pyknotic and shrunken at certain places. At the cellular level, definitely there are radiopathological changes in brain, however, very contrastingly, at the organism level ethological data show a better learned behaviour in mice post tritiated water exposure.
{"title":"Ethological studies in Swiss albino mice with special reference to the histology of the cerebellar tissue after an acute as well as a continuous low-dose tritiated water (HTO) exposure","authors":"N. Jain","doi":"10.1504/IJLR.2014.060912","DOIUrl":"https://doi.org/10.1504/IJLR.2014.060912","url":null,"abstract":"Health and environmental impact of tritium released from fusion reactor technology may end up as a worldwide problem in the final analysis. Pregnant Swiss albino mice were irradiated with 11.1 kBq ml–1 tritiated drinking water. The young ones born to them were maintained on tritiated water (HTO) at the same dose level and in adulthood, when tested in a maze showed an apparent increased learned behaviour over the controls, though statistically not significant. Similar results have been obtained when mice were acutely irradiated at a dose 185 kBq gm–1 body weight of tritiated water. Histologically, in the cerebellar tissue excised from mice brain after the ethology experiments, there was a depopulation of granule cells and the Purkinje cells appeared pyknotic and shrunken at certain places. At the cellular level, definitely there are radiopathological changes in brain, however, very contrastingly, at the organism level ethological data show a better learned behaviour in mice post tritiated water exposure.","PeriodicalId":14141,"journal":{"name":"International Journal of Low Radiation","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2014-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1504/IJLR.2014.060912","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"66668656","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2014-05-23DOI: 10.1504/IJLR.2014.060908
A. Akinlua, J. Fagbemi, F.O.I. Asubiojo, N. Torto
Thirty sedimentary organic rock samples were collected at different depths from three oil wells in the Niger Delta. The natural radionuclides in the samples were measured in order to determine their geochemical significance and radiological effect. The radionuclides were measured using gamma spectrometric technique. Natural occurring radionuclides identified were uranium, thorium and potassium. The average activity concentrations obtained were 2441.65±753.00, 28.31±8.83 and 14.49±4.46 Bq/kg for 40K, 232Th and 238U, respectively. The equivalent doses calculated from activity concentrations of the radionuclides ranged from 0.69–1.25, 0.89–1.18, and 1.19–1.38 mSv/year for Meji, Malu and Mefa oil wells, respectively. These values are slightly higher than the normal background radiation value of 1 mSv/year. The background radiation of 40K detected in these samples was high, the absorbed dose rate and equivalent dose was slightly high, which could pose intrinsically radiological health hazard because of their cumulative radiological effect in the environment.
{"title":"Natural radionuclides in Niger delta sedimentary organic rock samples","authors":"A. Akinlua, J. Fagbemi, F.O.I. Asubiojo, N. Torto","doi":"10.1504/IJLR.2014.060908","DOIUrl":"https://doi.org/10.1504/IJLR.2014.060908","url":null,"abstract":"Thirty sedimentary organic rock samples were collected at different depths from three oil wells in the Niger Delta. The natural radionuclides in the samples were measured in order to determine their geochemical significance and radiological effect. The radionuclides were measured using gamma spectrometric technique. Natural occurring radionuclides identified were uranium, thorium and potassium. The average activity concentrations obtained were 2441.65±753.00, 28.31±8.83 and 14.49±4.46 Bq/kg for 40K, 232Th and 238U, respectively. The equivalent doses calculated from activity concentrations of the radionuclides ranged from 0.69–1.25, 0.89–1.18, and 1.19–1.38 mSv/year for Meji, Malu and Mefa oil wells, respectively. These values are slightly higher than the normal background radiation value of 1 mSv/year. The background radiation of 40K detected in these samples was high, the absorbed dose rate and equivalent dose was slightly high, which could pose intrinsically radiological health hazard because of their cumulative radiological effect in the environment.","PeriodicalId":14141,"journal":{"name":"International Journal of Low Radiation","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2014-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1504/IJLR.2014.060908","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"66669095","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2014-05-23DOI: 10.1504/IJLR.2014.060910
N. K. Sethy, V. Jha, A. K. Sutar, P. Rath, P. Ravi, R. Tripathi
Dissolved radionuclides in the effluent of uranium mining industry were studied. Activity concentrations of uranium and radium were estimated in effluent water from different uranium mines and mill tailings ponds. The concentrations of U and 226Ra in untreated effluent water were found to be elevated. The concentrations of dissolved radionuclides in the adjacent aquatic streams and river were found to be of low range. The waste management technology used for removal process of dissolved radionuclides in the Effluent Treatment Plant (ETP) is found to be effective.
{"title":"Dissolved radionuclide in the industrial effluent of uranium facilities, Jaduguda, India","authors":"N. K. Sethy, V. Jha, A. K. Sutar, P. Rath, P. Ravi, R. Tripathi","doi":"10.1504/IJLR.2014.060910","DOIUrl":"https://doi.org/10.1504/IJLR.2014.060910","url":null,"abstract":"Dissolved radionuclides in the effluent of uranium mining industry were studied. Activity concentrations of uranium and radium were estimated in effluent water from different uranium mines and mill tailings ponds. The concentrations of U and 226Ra in untreated effluent water were found to be elevated. The concentrations of dissolved radionuclides in the adjacent aquatic streams and river were found to be of low range. The waste management technology used for removal process of dissolved radionuclides in the Effluent Treatment Plant (ETP) is found to be effective.","PeriodicalId":14141,"journal":{"name":"International Journal of Low Radiation","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2014-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1504/IJLR.2014.060910","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"66669113","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2014-01-01DOI: 10.1504/IJLR.2014.068256
E. Antar, S. Gafar, M. El-Ahdal
Radiochromic film has become an important tool to assess complex dose distributions. As a self–developing film, EBT2 is a perfect fit for the processor–less environment. Radiation dosimeters based on EBT2 containing active layer, marker dye (coded) and stabiliser have been prepared. EBT2 films undergo radiation when subjected to gamma rays inducing change in the absorption spectra in the film which converts from faint green to deep green peaking at 631 nm, and upon irradiation the new developed peak and their amplitudes with the original peak increase with the increase of absorbed dose. The useful dose range of this film is 1 cGy to 15 Gy. So it can be used as a dosimeter in the field of blood irradiation and radiotherapy. The effect of relative humidity during irradiation on the response of films as well as pre– and post–irradiation stability at different storage conditions was described.
{"title":"Suitability of gafchromic EBT2 films for dosimetry of low gamma–rays","authors":"E. Antar, S. Gafar, M. El-Ahdal","doi":"10.1504/IJLR.2014.068256","DOIUrl":"https://doi.org/10.1504/IJLR.2014.068256","url":null,"abstract":"Radiochromic film has become an important tool to assess complex dose distributions. As a self–developing film, EBT2 is a perfect fit for the processor–less environment. Radiation dosimeters based on EBT2 containing active layer, marker dye (coded) and stabiliser have been prepared. EBT2 films undergo radiation when subjected to gamma rays inducing change in the absorption spectra in the film which converts from faint green to deep green peaking at 631 nm, and upon irradiation the new developed peak and their amplitudes with the original peak increase with the increase of absorbed dose. The useful dose range of this film is 1 cGy to 15 Gy. So it can be used as a dosimeter in the field of blood irradiation and radiotherapy. The effect of relative humidity during irradiation on the response of films as well as pre– and post–irradiation stability at different storage conditions was described.","PeriodicalId":14141,"journal":{"name":"International Journal of Low Radiation","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2014-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1504/IJLR.2014.068256","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"66668901","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2014-01-01DOI: 10.1504/IJLR.2014.068257
J. C. Luca, D. López-Larraza
The goal of this study is to determine whether cysteimine, buthionine sulphoximide and dithitreitol protect CHO K1 cells against chromosomal aberrations induced by low doses of X–radiation, as well as whether radiation protection is related to physical properties of those thiols. Experimental design included four different treatments: (a) control, (b) cells treated with 5 mM of buthionine sulphoximide as well as cysteine and dithitreitol, (c) cells treated with 100 mGy of X–rays and (d) cells treated with 5 mM of each thiol and 100 mGy X–rays. In combined treatment, all chemical compounds were added 30 min before irradiation and remained until cell sacrifice (18 h). None of the three compounds studied showed a radioprotector effect. These results are consistent with the electrical charges and chemical structure of the three thiols.
{"title":"Effect of buthionine sulphoximine, cysteine and dithitreitol in cells exposed to low doses of radiation","authors":"J. C. Luca, D. López-Larraza","doi":"10.1504/IJLR.2014.068257","DOIUrl":"https://doi.org/10.1504/IJLR.2014.068257","url":null,"abstract":"The goal of this study is to determine whether cysteimine, buthionine sulphoximide and dithitreitol protect CHO K1 cells against chromosomal aberrations induced by low doses of X–radiation, as well as whether radiation protection is related to physical properties of those thiols. Experimental design included four different treatments: (a) control, (b) cells treated with 5 mM of buthionine sulphoximide as well as cysteine and dithitreitol, (c) cells treated with 100 mGy of X–rays and (d) cells treated with 5 mM of each thiol and 100 mGy X–rays. In combined treatment, all chemical compounds were added 30 min before irradiation and remained until cell sacrifice (18 h). None of the three compounds studied showed a radioprotector effect. These results are consistent with the electrical charges and chemical structure of the three thiols.","PeriodicalId":14141,"journal":{"name":"International Journal of Low Radiation","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2014-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1504/IJLR.2014.068257","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"66668914","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2014-01-01DOI: 10.1504/IJLR.2014.068258
H. A. A. Ghany
High altitude is characterised by hypoxic and hypobaric conditions. Exposure to high altitude is known to affect human physiology, specially blood oxygen tension and saturation. Also, oxygen, carbon dioxide and vacuum are known to affect some polymers used in radon detection. In the present work alpha track detector (CR–39 plastic) was used to assess the radon exhalation rates and effective radium in rock, soil, plants (wild herbs) and water samples measured at low altitude with normal oxygen and atmospheric pressure and compared with the corresponding measurements in hypoxic and hypobaric conditions at high altitude (2412 m above sea level). The data indicated that high–altitude conditions slightly affect the measurements of the radon concentration and its exhalation rate.
{"title":"Effect of the altitude on the concentration and exhalation rate of radon","authors":"H. A. A. Ghany","doi":"10.1504/IJLR.2014.068258","DOIUrl":"https://doi.org/10.1504/IJLR.2014.068258","url":null,"abstract":"High altitude is characterised by hypoxic and hypobaric conditions. Exposure to high altitude is known to affect human physiology, specially blood oxygen tension and saturation. Also, oxygen, carbon dioxide and vacuum are known to affect some polymers used in radon detection. In the present work alpha track detector (CR–39 plastic) was used to assess the radon exhalation rates and effective radium in rock, soil, plants (wild herbs) and water samples measured at low altitude with normal oxygen and atmospheric pressure and compared with the corresponding measurements in hypoxic and hypobaric conditions at high altitude (2412 m above sea level). The data indicated that high–altitude conditions slightly affect the measurements of the radon concentration and its exhalation rate.","PeriodicalId":14141,"journal":{"name":"International Journal of Low Radiation","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2014-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1504/IJLR.2014.068258","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"66668920","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2014-01-01DOI: 10.1504/IJLR.2014.068282
R. Fardid, M. Toossi, Abdolrahim Rezaee, Ariane Sadr Nabavi, H. Rafatpanah
Ionising radiation can cause different forms of DNA damage in living cells. Changes in biomarkers due to exposure to ionising radiation can be an appropriate tool for the immediate recognition of individuals exposed to radiation after a radiological accident or nuclear disaster. QPCR technique, as an approved method, was used for analysing the expression levels of sensitive genes following radiation exposure. Gene expression studies were performed on a group of 36 radiation workers and 36 matched–normal people without a history of radiation exposure. Mean gene expression values for control and irradiated groups were compared. There was significant difference between the mean gene expression of IFNg (p < 0.05), also significant difference was observed between the gene expression of TGFb1 (p < 0.05) in normal and irradiated groups. The logistic regression model is able to correctly identify 72.2% of irradiated samples (sensitivity) and 80.6% of normal samples (specificity).
{"title":"Expression of IFNg and TGFb1 genes can distinguish radiation workers from the normal population","authors":"R. Fardid, M. Toossi, Abdolrahim Rezaee, Ariane Sadr Nabavi, H. Rafatpanah","doi":"10.1504/IJLR.2014.068282","DOIUrl":"https://doi.org/10.1504/IJLR.2014.068282","url":null,"abstract":"Ionising radiation can cause different forms of DNA damage in living cells. Changes in biomarkers due to exposure to ionising radiation can be an appropriate tool for the immediate recognition of individuals exposed to radiation after a radiological accident or nuclear disaster. QPCR technique, as an approved method, was used for analysing the expression levels of sensitive genes following radiation exposure. Gene expression studies were performed on a group of 36 radiation workers and 36 matched–normal people without a history of radiation exposure. Mean gene expression values for control and irradiated groups were compared. There was significant difference between the mean gene expression of IFNg (p < 0.05), also significant difference was observed between the gene expression of TGFb1 (p < 0.05) in normal and irradiated groups. The logistic regression model is able to correctly identify 72.2% of irradiated samples (sensitivity) and 80.6% of normal samples (specificity).","PeriodicalId":14141,"journal":{"name":"International Journal of Low Radiation","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2014-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1504/IJLR.2014.068282","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"66669241","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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