Pub Date : 2016-01-01DOI: 10.1504/IJLR.2016.10002361
P. Venkatachalam, T.R. Muralidharan, S. Joseph, M. Bhavani, Venkateswarlu Raavi, Sakina Murtaza, Safa Abdul Syed Basheerudeen
Occupational radiation exposures for interventionalists are considered as the highest received doses among medical practitioners and contributing a risk of DNA damage. A significantly higher γ-H2AX foci and unstable chromosomal aberrations (p > 0.001) was observed in Peripheral Blood Lymphocytes (PBL) of medical professionals when compared to healthy volunteers, whereas translocations did not show any difference. The results suggest that low-dose protracted radiation exposure can induce DNA damages in PBL and can get repaired or misrepaired and develop into chromosomal aberrations.
{"title":"Assessment of early and late DNA damages in interventional radiologists exposed to protracted low dose and dose rate of X-radiation","authors":"P. Venkatachalam, T.R. Muralidharan, S. Joseph, M. Bhavani, Venkateswarlu Raavi, Sakina Murtaza, Safa Abdul Syed Basheerudeen","doi":"10.1504/IJLR.2016.10002361","DOIUrl":"https://doi.org/10.1504/IJLR.2016.10002361","url":null,"abstract":"Occupational radiation exposures for interventionalists are considered as the highest received doses among medical practitioners and contributing a risk of DNA damage. A significantly higher γ-H2AX foci and unstable chromosomal aberrations (p > 0.001) was observed in Peripheral Blood Lymphocytes (PBL) of medical professionals when compared to healthy volunteers, whereas translocations did not show any difference. The results suggest that low-dose protracted radiation exposure can induce DNA damages in PBL and can get repaired or misrepaired and develop into chromosomal aberrations.","PeriodicalId":14141,"journal":{"name":"International Journal of Low Radiation","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2016-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"66669553","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2015-09-19DOI: 10.1504/ijlr.2015.071761
S. Murugesan, S. Mullainathan, V. Ramasamy
The activity concentrations of 238U, 232Th and 40K have been determined by gamma ray spectrometry with an NaI(Tl) detector in sediments of Palar River, Tamil Nadu, India. The absorbed dose rate, radium equivalent concentration, external (Hex) and internal (Hin) hazardous indices are calculated from criteria formula and compared with the international recommended limits. The Radioactive Heat Production (RHP) rate and Excess Lifetime Cancer Risk (ELCR) are also calculated. The observed dose rate from ERDM (Environmental Radiation Dosimeter) at 1 m above the ground level at each site of the river is measured and correlated with calculated absorbed dose rate. The distribution of quartz, feldspar, magnetic susceptibility and weight of the magnetic minerals is correlated with radioactivity results. From the observations, the weight of the magnetic minerals is an index to identify the sediments of low or high radiological risk.
{"title":"Natural radioactivity and hazardous index of major South Indian river sediments","authors":"S. Murugesan, S. Mullainathan, V. Ramasamy","doi":"10.1504/ijlr.2015.071761","DOIUrl":"https://doi.org/10.1504/ijlr.2015.071761","url":null,"abstract":"The activity concentrations of 238U, 232Th and 40K have been determined by gamma ray spectrometry with an NaI(Tl) detector in sediments of Palar River, Tamil Nadu, India. The absorbed dose rate, radium equivalent concentration, external (Hex) and internal (Hin) hazardous indices are calculated from criteria formula and compared with the international recommended limits. The Radioactive Heat Production (RHP) rate and Excess Lifetime Cancer Risk (ELCR) are also calculated. The observed dose rate from ERDM (Environmental Radiation Dosimeter) at 1 m above the ground level at each site of the river is measured and correlated with calculated absorbed dose rate. The distribution of quartz, feldspar, magnetic susceptibility and weight of the magnetic minerals is correlated with radioactivity results. From the observations, the weight of the magnetic minerals is an index to identify the sediments of low or high radiological risk.","PeriodicalId":14141,"journal":{"name":"International Journal of Low Radiation","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2015-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1504/ijlr.2015.071761","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"66669288","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2015-09-19DOI: 10.1504/ijlr.2015.071764
K. S. Banerjee, D. Sengupta
The measurement of indoor radon in villages is very important as 50% of the world populations live in villages, and rural houses normally have very low air exchange rates. This study has estimated the possible indoor radon level from five types of rocks, which are readily available to build houses in Eastern Singhbhum district of India. In the process to calculate this radon inventory, radium content and radon flux rate were measured in the selected rocks. Then calculated radon emanation factor was compared with the possible indoor radon concentration computed from the available air ventilation rate of typical Indian houses. It was found that granite generated low radon level and it can be a good alternative choice as building material instead of other regionally used rocks. This study also suggests that important geological parameters, which develop and increase porosity, can effectively increase radon inventory.
{"title":"Importance of radon studies in rural areas and correlation of indoor radon level with radon inventory","authors":"K. S. Banerjee, D. Sengupta","doi":"10.1504/ijlr.2015.071764","DOIUrl":"https://doi.org/10.1504/ijlr.2015.071764","url":null,"abstract":"The measurement of indoor radon in villages is very important as 50% of the world populations live in villages, and rural houses normally have very low air exchange rates. This study has estimated the possible indoor radon level from five types of rocks, which are readily available to build houses in Eastern Singhbhum district of India. In the process to calculate this radon inventory, radium content and radon flux rate were measured in the selected rocks. Then calculated radon emanation factor was compared with the possible indoor radon concentration computed from the available air ventilation rate of typical Indian houses. It was found that granite generated low radon level and it can be a good alternative choice as building material instead of other regionally used rocks. This study also suggests that important geological parameters, which develop and increase porosity, can effectively increase radon inventory.","PeriodicalId":14141,"journal":{"name":"International Journal of Low Radiation","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2015-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1504/ijlr.2015.071764","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"66669323","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2015-09-19DOI: 10.1504/ijlr.2015.071747
S. Kansal, Rohit Mehra
The measurements of radium, thorium and potassium using gamma spectrometry and radon exhalation rates using solid-state nuclear track detectors (LR-115, Type-II plastic) are carried out in the soil samples collected from some parts of western districts of Haryana, India. The activity concentrations of 226Ra, 232Th and 40K range from 13.93 to 142 Bq kg−1, 35.95 to 91.78 Bq kg−1 and 299.57 to 1056.77 Bq kg−1, respectively. The values of total absorbed dose and annual effective dose (indoors and outdoors) were found to vary from 42.12 to 140.05 nGy h−1, 0.22 to 0.69 mSv y−1 and 0.05 to 0.17 mSv y−1 respectively. The radium equivalent activity (Raeq) in all the soil samples varies from 92.51 to 287.08 Bq kg−1 with an average of 184.15 Bq kg−1. The radium values are lower than the recommended safe limit of 370 Bq kg−1 hence there is no radiological risk to the residents of the studied area.
在印度哈里亚纳邦西部一些地区收集的土壤样本中，使用伽马能谱法测量镭、钍和钾，使用固态核径迹探测器(LR-115, ii型塑料)测量氡的呼出率。226Ra、232Th和40K的活性浓度分别为13.93 ~ 142 Bq kg - 1、35.95 ~ 91.78 Bq kg - 1和299.57 ~ 1056.77 Bq kg - 1。总吸收剂量和年有效剂量(室内和室外)分别在42.12 ~ 140.05 nGy h−1、0.22 ~ 0.69 mSv y−1和0.05 ~ 0.17 mSv y−1之间变化。所有土壤样品的镭当量活度(Raeq)变化范围为92.51 ~ 287.08 Bq kg - 1，平均为184.15 Bq kg - 1。镭值低于建议的安全限值370 Bq kg−1，因此对研究地区的居民没有辐射风险。
{"title":"Evaluation and analysis of 226Ra, 232Th and 40K and radon exhalation rate in the soil samples for health risk assessment","authors":"S. Kansal, Rohit Mehra","doi":"10.1504/ijlr.2015.071747","DOIUrl":"https://doi.org/10.1504/ijlr.2015.071747","url":null,"abstract":"The measurements of radium, thorium and potassium using gamma spectrometry and radon exhalation rates using solid-state nuclear track detectors (LR-115, Type-II plastic) are carried out in the soil samples collected from some parts of western districts of Haryana, India. The activity concentrations of 226Ra, 232Th and 40K range from 13.93 to 142 Bq kg−1, 35.95 to 91.78 Bq kg−1 and 299.57 to 1056.77 Bq kg−1, respectively. The values of total absorbed dose and annual effective dose (indoors and outdoors) were found to vary from 42.12 to 140.05 nGy h−1, 0.22 to 0.69 mSv y−1 and 0.05 to 0.17 mSv y−1 respectively. The radium equivalent activity (Raeq) in all the soil samples varies from 92.51 to 287.08 Bq kg−1 with an average of 184.15 Bq kg−1. The radium values are lower than the recommended safe limit of 370 Bq kg−1 hence there is no radiological risk to the residents of the studied area.","PeriodicalId":14141,"journal":{"name":"International Journal of Low Radiation","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2015-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1504/ijlr.2015.071747","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"66669276","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2015-09-19DOI: 10.1504/IJLR.2015.071766
L. Meza, M. Mandour, M. Shalaby, M. H. Hassan, N. Mohamed
Using high resolution gamma ray spectrometry, the terrestrial radionuclides from all phosphate rock samples were measured and results are presented. From the measured gamma ray spectra, activity concentrations were determined for 226Ra/238U (range from 122.5±6.9 to 8060±806 Bq kg−1), 232Th (range from 13.2±0.8 to 1201.3±77.3 Bq kg−1), 40K (range from 12.9±1.3 to 1827.6±93.9 Bq kg−1) and 137Cs (range from 0.5±0.017 to 70.58±1.25 Bq kg−1) with mean of 1832.32±00, 447.62±00, 399.46±00 and 22.98±0.43 Bq kg−1 respectively. Radium equivalent activity ranges from 219.27±00 to 9127.07±00 Bq kg−1 with mean of 2433.56±00 Bq kg−1. The total absorbed dose estimated at 1 metre above the ground varies from 102.1 to 3967.8 nGyh−1 with an average of 1055.9 nGy h−1. Investigation of uranium recorded a peak of 650±65ppm, this suggests the existing U concentration is over three times greater than economically viable and production of a cleaner fertiliser is favourable.
{"title":"A thorough investigation of the uranium concentration in phosphate mines: a case study of Minjingu phosphate mine, Arusha, United Republic of Tanzania","authors":"L. Meza, M. Mandour, M. Shalaby, M. H. Hassan, N. Mohamed","doi":"10.1504/IJLR.2015.071766","DOIUrl":"https://doi.org/10.1504/IJLR.2015.071766","url":null,"abstract":"Using high resolution gamma ray spectrometry, the terrestrial radionuclides from all phosphate rock samples were measured and results are presented. From the measured gamma ray spectra, activity concentrations were determined for 226Ra/238U (range from 122.5±6.9 to 8060±806 Bq kg−1), 232Th (range from 13.2±0.8 to 1201.3±77.3 Bq kg−1), 40K (range from 12.9±1.3 to 1827.6±93.9 Bq kg−1) and 137Cs (range from 0.5±0.017 to 70.58±1.25 Bq kg−1) with mean of 1832.32±00, 447.62±00, 399.46±00 and 22.98±0.43 Bq kg−1 respectively. Radium equivalent activity ranges from 219.27±00 to 9127.07±00 Bq kg−1 with mean of 2433.56±00 Bq kg−1. The total absorbed dose estimated at 1 metre above the ground varies from 102.1 to 3967.8 nGyh−1 with an average of 1055.9 nGy h−1. Investigation of uranium recorded a peak of 650±65ppm, this suggests the existing U concentration is over three times greater than economically viable and production of a cleaner fertiliser is favourable.","PeriodicalId":14141,"journal":{"name":"International Journal of Low Radiation","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2015-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1504/IJLR.2015.071766","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"66669331","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2014-07-15DOI: 10.1504/IJLR.2014.063410
C. Silva, C. C. Júnior
210Pb is widely distributed in the marine environment. The aim of this research, therefore, was to determine 210Pb concentrations in marine salt consumed by the population of Recife and calculate the ingestion dose of 210Pb due to marine salt consumption. The ion exchange resin method was used. The concentration of 210Pb varied from 4 to 365 Bq kg–1 in fresh weight. The estimated ingestion dose of 210Pb due to consumption of marine salt in the population of Recife was 1.2 Sv, at least three orders of magnitude above the maximum recommended level.
{"title":"210Pb in marine salt consumed by the inhabitants of Recife, Brazil","authors":"C. Silva, C. C. Júnior","doi":"10.1504/IJLR.2014.063410","DOIUrl":"https://doi.org/10.1504/IJLR.2014.063410","url":null,"abstract":"210Pb is widely distributed in the marine environment. The aim of this research, therefore, was to determine 210Pb concentrations in marine salt consumed by the population of Recife and calculate the ingestion dose of 210Pb due to marine salt consumption. The ion exchange resin method was used. The concentration of 210Pb varied from 4 to 365 Bq kg–1 in fresh weight. The estimated ingestion dose of 210Pb due to consumption of marine salt in the population of Recife was 1.2 Sv, at least three orders of magnitude above the maximum recommended level.","PeriodicalId":14141,"journal":{"name":"International Journal of Low Radiation","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2014-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1504/IJLR.2014.063410","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"66668794","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2014-07-15DOI: 10.1504/IJLR.2014.063409
A. Menon, R. Indu, Tiju Chacko, C. Nair
Cellular DNA damage, tissue antioxidant levels, serum parameters, blood count and histopathological alterations were examined in tissues of mice exposed to thoron (average radiation dose0.065 μSv/hr). Alkaline cometassay results indicated that inhalation of thoron caused significant increase in the damage to DNA of lung tissue, while there was no significant damage to DNA in bone marrow cells. A small increase in cellular DNA damage was also seen in blood leukocytesfollowing thoron exposure. Inhalation of thoron induced severe damage in the lung cells leading to their elimination by apoptosis. Histology of lungs showed areas of abnormalities. An increase in the level of inflammatory response mediator, NF-κB, was also observed in the lung tissue of exposed mice. The DNA damage in lung cells could be induced by high energy radiation emanating from radioactive decay of thoron and its progeny particularly the alpha radiation of 8.88 MeV from 212Po.
{"title":"Low-dose ionising radiation effects: effects of thoron inhalation","authors":"A. Menon, R. Indu, Tiju Chacko, C. Nair","doi":"10.1504/IJLR.2014.063409","DOIUrl":"https://doi.org/10.1504/IJLR.2014.063409","url":null,"abstract":"Cellular DNA damage, tissue antioxidant levels, serum parameters, blood count and histopathological alterations were examined in tissues of mice exposed to thoron (average radiation dose0.065 μSv/hr). Alkaline cometassay results indicated that inhalation of thoron caused significant increase in the damage to DNA of lung tissue, while there was no significant damage to DNA in bone marrow cells. A small increase in cellular DNA damage was also seen in blood leukocytesfollowing thoron exposure. Inhalation of thoron induced severe damage in the lung cells leading to their elimination by apoptosis. Histology of lungs showed areas of abnormalities. An increase in the level of inflammatory response mediator, NF-κB, was also observed in the lung tissue of exposed mice. The DNA damage in lung cells could be induced by high energy radiation emanating from radioactive decay of thoron and its progeny particularly the alpha radiation of 8.88 MeV from 212Po.","PeriodicalId":14141,"journal":{"name":"International Journal of Low Radiation","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2014-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1504/IJLR.2014.063409","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"66668759","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2014-07-15DOI: 10.1504/IJLR.2014.063411
J. Djounova, N. Chobanova, I. Guleva, A. Milchev, Iler Peyankov, K. Negoicheva, D. Panova
The aim of the study is to assess the health status of Kozloduy Nuclear Power Plant personnel in association with their occupational exposure to low doses of ionising radiation (IR) as well as with other factors of their working environment and to determine the probability of the occupational exposure to be a reason for the diagnosed malignant diseases (Probability of Causation – PC). More than 1000 occupationally exposed workers and nonexposed administrative staff have been studied during 1993–2008. No statistically significant variation in the average cumulative dose was found between the healthy people and the persons with at least one disorder. The highest rate of morbidity was registered in persons with doses up to 1 mSv. The analysis of parameters of peripheral blood showed that at occupational lowdose exposure the haemopoietic system completely preserves the tri-linear cell proliferation capacity of the bone marrow. The analysis of results of PC demonstrated that this is spontaneously arising malignant diseases, regardless of condition of work.
{"title":"Health monitoring of NPP workers","authors":"J. Djounova, N. Chobanova, I. Guleva, A. Milchev, Iler Peyankov, K. Negoicheva, D. Panova","doi":"10.1504/IJLR.2014.063411","DOIUrl":"https://doi.org/10.1504/IJLR.2014.063411","url":null,"abstract":"The aim of the study is to assess the health status of Kozloduy Nuclear Power Plant personnel in association with their occupational exposure to low doses of ionising radiation (IR) as well as with other factors of their working environment and to determine the probability of the occupational exposure to be a reason for the diagnosed malignant diseases (Probability of Causation – PC). More than 1000 occupationally exposed workers and nonexposed administrative staff have been studied during 1993–2008. No statistically significant variation in the average cumulative dose was found between the healthy people and the persons with at least one disorder. The highest rate of morbidity was registered in persons with doses up to 1 mSv. The analysis of parameters of peripheral blood showed that at occupational lowdose exposure the haemopoietic system completely preserves the tri-linear cell proliferation capacity of the bone marrow. The analysis of results of PC demonstrated that this is spontaneously arising malignant diseases, regardless of condition of work.","PeriodicalId":14141,"journal":{"name":"International Journal of Low Radiation","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2014-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1504/IJLR.2014.063411","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"66668804","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2014-07-15DOI: 10.1504/IJLR.2014.063412
V. Korogodina
At present, a possible radiation effect is estimated as a function of dose irradiation although it is strongly dependent more on the environmental factors. The consequences of low doses of internal irradiation linked to chronic soil contamination and of external irradiation associated with short or prolonged atmospheric impacts for plant populations in nature are analysed in this paper. The results revealed that the internal and external lab short and prolonged irradiations showed the same effects. In nature, soil contamination (~30 Bq/kg) limited survival of seeds to ~50% and increased their resistance to heat stress, whereas atmospheric impact (~0.12 μSv/h) combined with high summer temperature decreased viability to 20–30%. External atmospheric irradiations compared with background originate sporadically synergic radiation-heat effect which can be lethal for populations from time to time, whereas low-chronic internal soil contamination decreases seed survival significantly but increases resistance caus...
{"title":"A view on the effects induced by low irradiation contamination of soil and atmospheric impact on plant populations in nature","authors":"V. Korogodina","doi":"10.1504/IJLR.2014.063412","DOIUrl":"https://doi.org/10.1504/IJLR.2014.063412","url":null,"abstract":"At present, a possible radiation effect is estimated as a function of dose irradiation although it is strongly dependent more on the environmental factors. The consequences of low doses of internal irradiation linked to chronic soil contamination and of external irradiation associated with short or prolonged atmospheric impacts for plant populations in nature are analysed in this paper. The results revealed that the internal and external lab short and prolonged irradiations showed the same effects. In nature, soil contamination (~30 Bq/kg) limited survival of seeds to ~50% and increased their resistance to heat stress, whereas atmospheric impact (~0.12 μSv/h) combined with high summer temperature decreased viability to 20–30%. External atmospheric irradiations compared with background originate sporadically synergic radiation-heat effect which can be lethal for populations from time to time, whereas low-chronic internal soil contamination decreases seed survival significantly but increases resistance caus...","PeriodicalId":14141,"journal":{"name":"International Journal of Low Radiation","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2014-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1504/IJLR.2014.063412","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"66668844","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2014-07-15DOI: 10.1504/IJLR.2014.063414
F. Hakkim, Miwa Miura, N. Matsuda, Ahmed Suleiman Alharassi, G. Guillemin, M. Yamauchi, G. Arivazhagan, Hyuk Song
Ionising radiation (γ or X-rays) is the mandatory tool to treat cancer despite its detrimental effects in particular on skin cells which lead to severe dermatological diseases and carcinogenesis. Natural antioxidants caffeic acid (CA), rosmarinic acid (RA), trans cinnamic acid (TCA), p-coumaric acid (PCA), and hydroxyphenyllactic acid (HPA) acid are known to be potent anticancer and antioxidant agents. Current study is designed to provide experimental evidence as these compounds offer radiation protection for skin cells. Non-toxic concentrations of CA, RA, TCA, PCA, and HPA were tested for radiation protection, γ-radiation induced intracellular reactive oxygen species (ROS) by flow cytometry and DNA double strand break in human keratinocytes (HaCaT cells) by immunocytochemistry. CA, RA and TCA pretreatment can protect the HaCaT cells by 40%, 20%, 15% respectively through scavenging γ-radiation induced ROS and decreasing number of post irradiation 53bp1 foci. Inclusion of these compounds in chemo-radiother...
{"title":"An in vitro evidence for caffeic acid, rosmarinic acid and trans cinnamic acid as a skin protectant against γ-radiation","authors":"F. Hakkim, Miwa Miura, N. Matsuda, Ahmed Suleiman Alharassi, G. Guillemin, M. Yamauchi, G. Arivazhagan, Hyuk Song","doi":"10.1504/IJLR.2014.063414","DOIUrl":"https://doi.org/10.1504/IJLR.2014.063414","url":null,"abstract":"Ionising radiation (γ or X-rays) is the mandatory tool to treat cancer despite its detrimental effects in particular on skin cells which lead to severe dermatological diseases and carcinogenesis. Natural antioxidants caffeic acid (CA), rosmarinic acid (RA), trans cinnamic acid (TCA), p-coumaric acid (PCA), and hydroxyphenyllactic acid (HPA) acid are known to be potent anticancer and antioxidant agents. Current study is designed to provide experimental evidence as these compounds offer radiation protection for skin cells. Non-toxic concentrations of CA, RA, TCA, PCA, and HPA were tested for radiation protection, γ-radiation induced intracellular reactive oxygen species (ROS) by flow cytometry and DNA double strand break in human keratinocytes (HaCaT cells) by immunocytochemistry. CA, RA and TCA pretreatment can protect the HaCaT cells by 40%, 20%, 15% respectively through scavenging γ-radiation induced ROS and decreasing number of post irradiation 53bp1 foci. Inclusion of these compounds in chemo-radiother...","PeriodicalId":14141,"journal":{"name":"International Journal of Low Radiation","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2014-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1504/IJLR.2014.063414","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"66668858","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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