Aim: It was aimed to examine the complication risk perception and diabetes self-management skills of individuals with diabetes. Material and Methods: The data of the descriptive and relational study were collected using google forms. The sample consists of 153 diabetic individuals. Data were collected with the recognition form, Diabetes Mellitus-Risk Perception Scale, and Diabetes Self-Management Skills Scale. Number, percentage, mean, standard deviation and median were used as descriptive statistical methods in the evaluation of the data. The distribution of the data was evaluated with the Kolmogorov-Smirnov and Shapiro-Wilk test. Mann-Whitney U test, Kruskal- Wallis test and Spearman correlation analysis were used to evaluate non-parametric data. Results: The mean age of the sample was 49.96 years, 51% were female, 24.8% were illiterate, 5.2% had postgraduate education, 45.1% had poor income, 60.1% had Type 2 diabetes and 36.6% had the highest It has few complications. 87.6% of individuals with diabetes were worried about the development of complications, their self-management scores were found to be higher than those of the nonconcerned group, and a statistically significant difference was found (p
{"title":"Investigation of Diabetes Complication Risk Perception and Diabetes Self-Management Skills in Individuals with Diabetes","authors":"Mehmet Aytemur, B. Inkaya","doi":"10.25048/tudod.1099172","DOIUrl":"https://doi.org/10.25048/tudod.1099172","url":null,"abstract":"Aim: It was aimed to examine the complication risk perception and diabetes self-management skills of individuals with diabetes. \u0000Material and Methods: The data of the descriptive and relational study were collected using google forms. The sample consists of 153 \u0000diabetic individuals. Data were collected with the recognition form, Diabetes Mellitus-Risk Perception Scale, and Diabetes Self-Management \u0000Skills Scale. Number, percentage, mean, standard deviation and median were used as descriptive statistical methods in the evaluation of \u0000the data. The distribution of the data was evaluated with the Kolmogorov-Smirnov and Shapiro-Wilk test. Mann-Whitney U test, Kruskal- \u0000Wallis test and Spearman correlation analysis were used to evaluate non-parametric data. \u0000Results: The mean age of the sample was 49.96 years, 51% were female, 24.8% were illiterate, 5.2% had postgraduate education, 45.1% \u0000had poor income, 60.1% had Type 2 diabetes and 36.6% had the highest It has few complications. 87.6% of individuals with diabetes \u0000were worried about the development of complications, their self-management scores were found to be higher than those of the nonconcerned \u0000group, and a statistically significant difference was found (p","PeriodicalId":141643,"journal":{"name":"Turkish Journal of Diabetes and Obesity","volume":"749 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122970118","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
A. Kalkan, Bilge Başdoğan, Özge Özer, Fatma Belgin Efe, Nur Kebapçi, A. Akalın, Göknur Yorulmaz
Amaç: Gerçek hayatta yeni nesil insülin glarjin u-300'ün açlık kan şekeri, HbA1c, LDL ve trigliserit düzeylerine etkisini değerlendirmeyi amaçladık. Gereç ve Yöntemler: Eskişehir Osmangazi Üniversitesi Endokrinoloji ve Metabolizma polikliniğine 2019 yılında başvuran, eski nesil bazal insülin yerine glargine u-300 kullanılan ve antilipidemik tedavisi değişmeyen hastaları geriye dönük olarak inceledik. Başlangıçta ve 3 ay sonra açlık kan şekeri(mg/dl), HbA1c(%), LDL(mg/dl) ve trigliserit(mg/dl) değerlerini karşılaştırdık. Biz de bu verileri cinsiyetlere continayırarak değerlendirdik. Sürekli değişkenler için Shapiro-Wilk normallik testi yapıldı. Normal dağılım gösteren değişkenler için paired sample t testi, normal dağılım göstermeyen değişkenler için Wilcoxon Signed Ranks testi uygulandı. Bulgular: 109 hasta ile ilgili veriler analiz edildi. Açlık kan şekeri ortalaması ve medyan değeri kontrolde glarjin u-300'e başladıktan sonra azaldı. Ancak istatistiksel olarak farklı değildi(p=0,06). HbA1c kontrol değeri (%8,8) başlangıç değerine (%9,61) göre istatistiksel olarak anlamlı derecede azaldı (p
研究目的我们旨在评估新一代胰岛素格列卫u-300在实际生活中对空腹血糖、HbA1c、低密度脂蛋白和甘油三酯水平的影响。 材料与方法：我们回顾性分析了2019年向埃斯基谢希尔-奥斯曼加齐大学内分泌与代谢门诊申请就诊的患者，这些患者使用格列卫u-300替代了老一代基础胰岛素，且抗脂治疗没有改变。我们比较了基线和 3 个月后的空腹血糖（毫克/分升）、HbA1c（%）、低密度脂蛋白（毫克/分升）和甘油三酯（毫克/分升）值。 我们还按性别对这些数据进行了评估。 对连续变量进行了 Shapiro-Wilk 正态性检验。对正态分布变量采用配对样本 t 检验，对非正态分布变量采用 Wilcoxon Signed Ranks 检验。结果分析了 109 名患者的数据。对照组患者开始使用格列宁 u-300 后，空腹血糖的平均值和中位值均有所下降。但在统计学上没有差异（P=0.06）。与基线值（9.61%）相比，HbA1c 控制值（8.8%）在统计学上有显著下降（p
{"title":"Glargine u300'ün Düşük Yoğunluklu Lipoprotein (LDL), Trigliserid (TG) ve Kan Şekeri Düzeyleri Üzerindeki Etkileri: Gerçek Yaşam Sonuçları","authors":"A. Kalkan, Bilge Başdoğan, Özge Özer, Fatma Belgin Efe, Nur Kebapçi, A. Akalın, Göknur Yorulmaz","doi":"10.25048/tudod.1092781","DOIUrl":"https://doi.org/10.25048/tudod.1092781","url":null,"abstract":"Amaç: Gerçek hayatta yeni nesil insülin glarjin u-300'ün açlık kan şekeri, HbA1c, LDL ve trigliserit düzeylerine etkisini değerlendirmeyi \u0000amaçladık. \u0000Gereç ve Yöntemler: Eskişehir Osmangazi Üniversitesi Endokrinoloji ve Metabolizma polikliniğine 2019 yılında başvuran, eski nesil \u0000bazal insülin yerine glargine u-300 kullanılan ve antilipidemik tedavisi değişmeyen hastaları geriye dönük olarak inceledik. Başlangıçta ve \u00003 ay sonra açlık kan şekeri(mg/dl), HbA1c(%), LDL(mg/dl) ve trigliserit(mg/dl) değerlerini karşılaştırdık. Biz de bu verileri cinsiyetlere continayırarak \u0000değerlendirdik. Sürekli değişkenler için Shapiro-Wilk normallik testi yapıldı. Normal dağılım gösteren değişkenler için paired \u0000sample t testi, normal dağılım göstermeyen değişkenler için Wilcoxon Signed Ranks testi uygulandı. \u0000Bulgular: 109 hasta ile ilgili veriler analiz edildi. Açlık kan şekeri ortalaması ve medyan değeri kontrolde glarjin u-300'e başladıktan \u0000sonra azaldı. Ancak istatistiksel olarak farklı değildi(p=0,06). HbA1c kontrol değeri (%8,8) başlangıç değerine (%9,61) göre istatistiksel \u0000olarak anlamlı derecede azaldı (p","PeriodicalId":141643,"journal":{"name":"Turkish Journal of Diabetes and Obesity","volume":"161 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127295430","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Type 1 diabetes is a process that children with diabetes and their parents can manage through repetitive training, care and close monitoring that they need to continue throughout their lives at the time of diagnosis. Type 1 forms diabetes management components into insulin treatment, healthy nutrition, physical activity, self-monitoring, multidisciplinary close-up and nursing approach. Insulintherapy is central to these components. With the development of diabetes technologies, an electromechanical pump entered the lives of the diabetic child and his or her parents, who automatically sends insulin continuously.In this compilation article, the advantages and disadvantages of the insulin infusion pump, which has become widely used globally, have been discussed in detail in the literature.
{"title":"Problems in Insulin Pump Management and Suggestions for Solutions in Children and Adolescents with Type 1 Diabetes","authors":"Günay Demir, Emine Çubukcu, Nurdan Akçay","doi":"10.25048/tudod.1105407","DOIUrl":"https://doi.org/10.25048/tudod.1105407","url":null,"abstract":"Type 1 diabetes is a process that children with diabetes and their parents can manage through repetitive training, care and close monitoring \u0000that they need to continue throughout their lives at the time of diagnosis. Type 1 forms diabetes management components into insulin \u0000treatment, healthy nutrition, physical activity, self-monitoring, multidisciplinary close-up and nursing approach. Insulintherapy is \u0000central to these components. With the development of diabetes technologies, an electromechanical pump entered the lives of the diabetic \u0000child and his or her parents, who automatically sends insulin continuously.In this compilation article, the advantages and disadvantages \u0000of the insulin infusion pump, which has become widely used globally, have been discussed in detail in the literature.","PeriodicalId":141643,"journal":{"name":"Turkish Journal of Diabetes and Obesity","volume":"62 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131011979","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Aim: The aim of the study is to evaluate the frequency of food consumption of university students and to examine the effect of nutritional knowledge levels on Body Mass Index (BMI). Material and Methods: A questionnaire consisting of sociodemographic characteristics, nutritional habits, general nutrition information questionnaire (GBBA) and food consumption frequency was applied to 812 students studying at Istanbul Aydın University. Data were analyzed with SPSS v26. Results: The average age of the student is 20.87±1.27 years, 68.4% of the students are female and 31.6% are male. The mean BMI of the students was 22.82±2.91 kg/m2, 8.7% were underweight in terms of BMI, 65.3% were normal weight, 22.8% were obese and 3.2% were obese. GBBA point average of students; It is 253.92±25.64, and the median score of male students [131 (101-167)] in GBBA's “Nutrition Sources” sub-factor score is statistically higher than female students [128 (95-174)] (U= 63410; p
{"title":"Evaluation of Nutritional Consumption Frequency of and Investigation of the Effect of Nutritional Knowledge Levels on Body Mass Index on University Students: A Sample of Istanbul Aydin University","authors":"Djiba Sacko, M. Arslan","doi":"10.25048/tudod.1119104","DOIUrl":"https://doi.org/10.25048/tudod.1119104","url":null,"abstract":"Aim: The aim of the study is to evaluate the frequency of food consumption of university students and to examine the effect of nutritional \u0000knowledge levels on Body Mass Index (BMI). \u0000Material and Methods: A questionnaire consisting of sociodemographic characteristics, nutritional habits, general nutrition information \u0000questionnaire (GBBA) and food consumption frequency was applied to 812 students studying at Istanbul Aydın University. Data were \u0000analyzed with SPSS v26. \u0000Results: The average age of the student is 20.87±1.27 years, 68.4% of the students are female and 31.6% are male. The mean BMI of the \u0000students was 22.82±2.91 kg/m2, 8.7% were underweight in terms of BMI, 65.3% were normal weight, 22.8% were obese and 3.2% were \u0000obese. GBBA point average of students; It is 253.92±25.64, and the median score of male students [131 (101-167)] in GBBA's “Nutrition \u0000Sources” sub-factor score is statistically higher than female students [128 (95-174)] (U= 63410; p","PeriodicalId":141643,"journal":{"name":"Turkish Journal of Diabetes and Obesity","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129488668","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Aim: The aim of this study is to examine the effects of Fitness (Full Body) and EMS (Electromyostimulation) training on body composition. Material and Methods: A total of 128 volunteers, Fitness (72) and EMS (56), participated in the study. 26.6% of the participants are between the ages of 30 and below, 36.7% of them are between 31-40 years old, 28.9% of them are between 41-50 years old and 7.8% are over 50 years old. Participants exercising fitness and EMS (mihabody) trainings in the presence of expert personal trainers, two days a week, for a total of 4 weeks (8 training sessions). Body composition measurements of the participants were carried out by Bioelectric Impedance Analysis. “IBM SPSS version 21.0” was used for the statistical evaluation of the data. Whole body, leg, arm and trunk measurments, of the participants were taken prior to and after 4-week training. The data obtained were classified as pre-test and post-test respectively. First of all the pre and post test results of the total body, leg, arm and trunk were compared and to perform this comparison Paired Sample T-test was applied. Results: At the end of the study, in both training techniques there is avarage of 2.360 kg loss of total body fat between pre and post tests this can be considered meaningful with 95% reliability (p
目的:本研究的目的是探讨健身(全身)和肌电刺激(EMS)训练对身体成分的影响。材料与方法:共有128名志愿者参与研究，其中Fitness(72)和EMS(56)。26.6%的参与者年龄在30岁以下，36.7%的参与者年龄在31-40岁之间，28.9%的参与者年龄在41-50岁之间，7.8%的参与者年龄在50岁以上。参与者在专业私人教练的指导下进行健身和EMS (mihabody)训练，每周两天，共4周(8次训练)。通过生物电阻抗分析对参与者的身体成分进行测量。采用IBM SPSS version 21.0对数据进行统计评价。在训练前和训练后，测量了参与者的全身、腿部、手臂和躯干的尺寸。所得数据分别分为前测和后测。首先对全身、腿部、手臂和躯干的前后检验结果进行比较，采用配对样本t检验进行比较。结果:在研究结束时，在两种训练技术中，在测试前后平均减少了2.360 kg的全身脂肪，这可以被认为是有意义的，可靠性为95% (p
{"title":"The Effects of Fitness and EMS (Electromyostimulation) Training Techniques on Body Composition","authors":"G. Bostan, M. Gümüş","doi":"10.25048/tudod.1068060","DOIUrl":"https://doi.org/10.25048/tudod.1068060","url":null,"abstract":"Aim: The aim of this study is to examine the effects of Fitness (Full Body) and EMS (Electromyostimulation) training on body composition. \u0000Material and Methods: A total of 128 volunteers, Fitness (72) and EMS (56), participated in the study. 26.6% of the participants are between \u0000the ages of 30 and below, 36.7% of them are between 31-40 years old, 28.9% of them are between 41-50 years old and 7.8% are over 50 years \u0000old. Participants exercising fitness and EMS (mihabody) trainings in the presence of expert personal trainers, two days a week, for a total \u0000of 4 weeks (8 training sessions). Body composition measurements of the participants were carried out by Bioelectric Impedance Analysis. \u0000“IBM SPSS version 21.0” was used for the statistical evaluation of the data. Whole body, leg, arm and trunk measurments, of the participants \u0000were taken prior to and after 4-week training. The data obtained were classified as pre-test and post-test respectively. First of all the pre \u0000and post test results of the total body, leg, arm and trunk were compared and to perform this comparison Paired Sample T-test was applied. \u0000Results: At the end of the study, in both training techniques there is avarage of 2.360 kg loss of total body fat between pre and post tests \u0000this can be considered meaningful with 95% reliability (p","PeriodicalId":141643,"journal":{"name":"Turkish Journal of Diabetes and Obesity","volume":"11 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127128230","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Kafeinin Ağırlık Yönetimine Etkileri","authors":"Şeyma Kablan, N. Erdem","doi":"10.25048/tudod.970965","DOIUrl":"https://doi.org/10.25048/tudod.970965","url":null,"abstract":"","PeriodicalId":141643,"journal":{"name":"Turkish Journal of Diabetes and Obesity","volume":"17 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128035455","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
İnci Turan, Candan Sağlam, Salih Erdem, Hale SAYAN ÖZAÇMAK
Aim: Glucagon-like peptide 1 (GLP-1) is an important incretin hormone secreted from enteroendocrine L cells. GLP-1 analogs are used for the treatment of diabetes and obesity. Ovarian hormones are well known in playing critical roles in regulating cardiovascular functions. Cardiovascular disease incidence increases in postmenopausal women. The aim of this study was to investigate the effect of administration of liraglutide, a GLP 1 analogue, on cardiac function and cardiac tissue oxidative stress in ovariectomized rats. Material and Methods: Thirty two young female Wistar albino rats were used in the study. Subjects were randomly divided into control, liraglutide-treated control, ovariectomized (OVX), and liraglutide-treated OVX groups. Ovariectomy and sham surgical procedures were performed in 2-month-old female rats. Liraglutide treatment (150µg/kg, subcutaneous, 14 days) was started five weeks after the ovariectomy operation. After measuring the heart rate and blood pressure at the end of the 14-day period, the animals were sacrificed, brown and white adipose tissue weights, and heart tissue malondialdehyde (MDA), reduced glutathione (GSH), nitrate, glycogen and ascorbic acid levels were measured. cardiac glycogen level was increased in the OVX group treated with OVX and liraglutide compared to the control group. Nitral levels in the heart tissue were found to be decreased with ovarectomy. Liraglutide treatment maintained nitrate levels in the heart at control levels. In addition, liraglutide administration reduced retroperitoneal fat deposition in OVX rats. Conclusion: Our results showed that GLP-1 administration was effective in reducing the increased blood pressure due to ovariectomy and maintaining the decreased GSH level in the heart tissue.. Therefore, GLP-1 analogs can be considered as potential therapeutic agents in the regulation of blood pressure in the postmenopausal period.
{"title":"Ovariektomize Sıçanlarda Liraglutid’in Kalp Fonksiyonları Üzerine Etkisi","authors":"İnci Turan, Candan Sağlam, Salih Erdem, Hale SAYAN ÖZAÇMAK","doi":"10.25048/tudod.1074076","DOIUrl":"https://doi.org/10.25048/tudod.1074076","url":null,"abstract":"Aim: Glucagon-like peptide 1 (GLP-1) is an important incretin hormone secreted from enteroendocrine L cells. GLP-1 analogs are used for the treatment of diabetes and obesity. Ovarian hormones are well known in playing critical roles in regulating cardiovascular functions. Cardiovascular disease incidence increases in postmenopausal women. The aim of this study was to investigate the effect of administration of liraglutide, a GLP 1 analogue, on cardiac function and cardiac tissue oxidative stress in ovariectomized rats. Material and Methods: Thirty two young female Wistar albino rats were used in the study. Subjects were randomly divided into control, liraglutide-treated control, ovariectomized (OVX), and liraglutide-treated OVX groups. Ovariectomy and sham surgical procedures were performed in 2-month-old female rats. Liraglutide treatment (150µg/kg, subcutaneous, 14 days) was started five weeks after the ovariectomy operation. After measuring the heart rate and blood pressure at the end of the 14-day period, the animals were sacrificed, brown and white adipose tissue weights, and heart tissue malondialdehyde (MDA), reduced glutathione (GSH), nitrate, glycogen and ascorbic acid levels were measured. cardiac glycogen level was increased in the OVX group treated with OVX and liraglutide compared to the control group. Nitral levels in the heart tissue were found to be decreased with ovarectomy. Liraglutide treatment maintained nitrate levels in the heart at control levels. In addition, liraglutide administration reduced retroperitoneal fat deposition in OVX rats. Conclusion: Our results showed that GLP-1 administration was effective in reducing the increased blood pressure due to ovariectomy and maintaining the decreased GSH level in the heart tissue.. Therefore, GLP-1 analogs can be considered as potential therapeutic agents in the regulation of blood pressure in the postmenopausal period.","PeriodicalId":141643,"journal":{"name":"Turkish Journal of Diabetes and Obesity","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128558168","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Leptin, Mikrobiyota ve Obezite İlişkisi","authors":"T. Şahin, Duygu Tozcu","doi":"10.25048/tudod.1005455","DOIUrl":"https://doi.org/10.25048/tudod.1005455","url":null,"abstract":"","PeriodicalId":141643,"journal":{"name":"Turkish Journal of Diabetes and Obesity","volume":"9 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127001242","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Aim: The contemporaneous increase in type 1 diabetes (T1D) and obesity prevalence in children has led to conflicting reports regarding the effects of weight excess on beta-cell function and clinical manifestation of T1D. We aimed to analyze the association between body mass index (BMI) and beta-cell function in a large cohort of new-onset T1D youth. Material and Methods: This study included 204 consecutive children with T1D aged 1-18 years. We retrospectively reviewed the medical data. The preservation of C-peptide was defined as a C-peptide level ≥0.6 ng/mL. Comparisons of variables between groups were made using appropriate statistical procedures. Results: Eighteen percent of children were overweight or obese. Overweight/obesity was associated with significantly higher C-peptide levels at onset [0.57 (0.05-2.99) vs 0.41 (0.05-2.58) ng/ml, p=0.01]. Preservation of C-peptide levels was observed in 67% of patients. Patients with preserved C-peptide levels were older at onset [10.4 (1.9-16.5) vs 7.5 (1.1-17.3) yr, p<0.001], more likely to be pubertal (61.2% vs 22.6%, p<0.001) and had a higher BMI SDS (0.03±1.37 vs -0.67±1.47, p=0.001). The proportion of individuals with preserved C-peptide levels increased with increasing BMI, but the difference did not reach statistical significance (29.9% to 45.9%, p=0.06). While there was a positive correlation between BMI SDS and C-peptide levels (rs=0.24, p=0.001), HbA1c levels negatively correlated with BMI SDS (r=-0.16, p=0.025). proportion of the study population. Obese and overweight children had a greater residual beta-cell function at the onset of T1D. It could be speculated that they were diagnosed at an earlier phase of beta-cell damage.
{"title":"Preservation of C-Peptide Levels in Children with New-Onset Type 1 Diabetes: A Comparison Based on Body Mass Index","authors":"E. A. Cimbek, Mehmet Aykut Öztürk, G. Karagüzel","doi":"10.25048/tudod.1059061","DOIUrl":"https://doi.org/10.25048/tudod.1059061","url":null,"abstract":"Aim: The contemporaneous increase in type 1 diabetes (T1D) and obesity prevalence in children has led to conflicting reports regarding the effects of weight excess on beta-cell function and clinical manifestation of T1D. We aimed to analyze the association between body mass index (BMI) and beta-cell function in a large cohort of new-onset T1D youth. Material and Methods: This study included 204 consecutive children with T1D aged 1-18 years. We retrospectively reviewed the medical data. The preservation of C-peptide was defined as a C-peptide level ≥0.6 ng/mL. Comparisons of variables between groups were made using appropriate statistical procedures. Results: Eighteen percent of children were overweight or obese. Overweight/obesity was associated with significantly higher C-peptide levels at onset [0.57 (0.05-2.99) vs 0.41 (0.05-2.58) ng/ml, p=0.01]. Preservation of C-peptide levels was observed in 67% of patients. Patients with preserved C-peptide levels were older at onset [10.4 (1.9-16.5) vs 7.5 (1.1-17.3) yr, p<0.001], more likely to be pubertal (61.2% vs 22.6%, p<0.001) and had a higher BMI SDS (0.03±1.37 vs -0.67±1.47, p=0.001). The proportion of individuals with preserved C-peptide levels increased with increasing BMI, but the difference did not reach statistical significance (29.9% to 45.9%, p=0.06). While there was a positive correlation between BMI SDS and C-peptide levels (rs=0.24, p=0.001), HbA1c levels negatively correlated with BMI SDS (r=-0.16, p=0.025). proportion of the study population. Obese and overweight children had a greater residual beta-cell function at the onset of T1D. It could be speculated that they were diagnosed at an earlier phase of beta-cell damage.","PeriodicalId":141643,"journal":{"name":"Turkish Journal of Diabetes and Obesity","volume":"7 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122503061","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
京公网安备 11010802042870号
京ICP备2023020795号-1
扫码关注我们
求助内容：
应助结果提醒方式：