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Gestasyonel Diyabet ile IL8/CXCL8 rs4073 Gen Polimorfizmi Arasındaki İlişkinin Araştırılması
Pub Date : 2023-04-28 DOI: 10.25048/tudod.1198053
Güneş ÇAKMAK GENÇ, Sevim KARAKAŞ ÇELİK, Mürsel Hazaloğlu, M. Harma, Ahmet Dursun
Amaç: Gestasyonel Diyabet (GDM) ilk defa gebelikte tanı konulan glukoz intoleransıdır. Hem anne hem de bebekte komplikasyon riskini artıran GDM için ileri gebelik yaşı, çok sayıda parite, önceki gebelikte GDM öyküsü, genetik faktörler gibi birçok risk faktörü tanımlanmıştır. Ayrıca bazı inflamatuar mediatörler, kemokinler ve onları kodlayan genlerin polimorfizmlerinin GDM ile ilişkisi gösterilmiştir. Biz bu çalışmada GDM tanısı konulan gebelerle sağlıklı gebelerdeki genotip ve allel frekans dağılımlarını karşılaştırarak, GDM yatkınlığı ile IL8/CXCL8 rs4073 (251A/T) gen polimorfizminin ilişkisini belirlemeyi amaçladık. Gereç ve Yöntemler: Çalışmamıza GDM tanılı 100 gebe ve kontrol grubu olarak 100 sağlıklı gebe dahil edilmiştir. Tüm katılımcılar Zonguldak Bülent Ecevit Üniversitesi Tıp Fakültesi Hastanesi Kadın Hastalıkları ve Doğum Anabilim Dalı’nda takip edilmiştir. IL8/ CXCL8 rs4073 gen polimorfizminin genotiplenmesi, polimeraz zincir reaksiyonu bazlı restriksiyon fragman uzunluk polimorfizmi (PCR-RFLP) yöntemi kullanılarak belirlenmiştir. GDM hastalarında ve kontrollerde her bir gen polimorfizminin genotip sıklığını karşılaştırmak için χ2 testi kullanıldı. Bulgular: Gestasyonel diyabetli gebelerle sağlıklı gebeler arasında rs4073 polimorfizmi genotip ve allel frekans dağılımları açısından istatistiksel olarak anlamlı bir farklılık saptanmamıştır (sırasıyla; p=0,260, p=1,000). Sonuç: Bulgularımız IL8/CXCL8 rs4073 gen polimorfizminin GDM’ye yatkınlıkla ilişkili olmadığını göstermekle birlikte bulgularımızın doğrulanması için farklı etnik grupları içeren geniş örneklem büyüklükleriyle, katılımcıların vücut kütle indeksleri, gebelik öncesi kiloları gibi klinik parametreler de dahil edilerek yapılacak ileri çalışmalara ihtiyaç vardır
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引用次数: 0
The Relationship Between Long-Term Glycemic Control and Partial Remission in Type 1 Diabetes: A Retrospective Study 1型糖尿病长期血糖控制与部分缓解的关系:一项回顾性研究
Pub Date : 2022-12-29 DOI: 10.25048/tudod.1170939
E. A. Cimbek, Semiha Bekfi̇lavi̇oğlu, G. Karagüzel
Aim: Partial remission (PR) is a significant period in the early course of type 1 diabetes (T1D) with implications for diabetes management. We aimed to investigate whether long-term hemoglobin A1c (HbA1c) outcomes in T1D differed as a result of experiencing PR. We also analyzed the demographic and clinical factors that may influence long-term glycemic control. Material and methods: We retrospectively tracked the HbA1c values of 131 children and adolescents with T1D over a 5-year period. Patients were stratified into low (
目的:部分缓解(PR)是1型糖尿病(T1D)早期病程中的一个重要时期,对糖尿病管理具有重要意义。我们的目的是调查长期血红蛋白A1c (HbA1c)结果是否因经历PR而不同。我们还分析了可能影响长期血糖控制的人口统计学和临床因素。材料和方法:我们回顾性追踪了131例T1D儿童和青少年患者5年的HbA1c值。患者被分为低(
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引用次数: 0
The Comparison of Food Addiction Rates and Characteristics Between Obese and Non-Obese Individuals: A Cross-Sectional Study 肥胖和非肥胖个体食物成瘾率和特征的比较:一项横断面研究
Pub Date : 2022-12-29 DOI: 10.25048/tudod.1159245
H. H. Mutlu, Hasan Huseyin Mutlu
Aim: Even though obesity and food addiction have been linked, only a small number of obese individuals fulfill the diagnostic criteria for food addiction, on the other hand some normal and underweight people also meet these criteria. To investigate the difference between the prevalence of food addiction between obese and non-obese persons using Yale Food Addiction Scale. Material and Methods: A demographic information form and Yale Food Addiction Scale was applied to obese and non-obese individiuals admitted to family medicine and obesity outpatient clinic. Significant differences of normally distributed data were assessed using a t-test, and significant differences of not normally distributed data were analyzed using the Mann-Whitney U test. Categorical data were expressed as percentages. The associations between food addiction and age, BMI, gender, and smoking status and the associationsbetween gender, smoking, food addiction, and obesity were determined by using the established a binary logistic regression models. P
目的:虽然肥胖和食物成瘾有联系,但只有少数肥胖者符合食物成瘾的诊断标准,另一方面,一些正常和体重过轻的人也符合这些标准。运用耶鲁食物成瘾量表探讨肥胖者与非肥胖者食物成瘾患病率的差异。材料与方法:采用人口统计学信息表和耶鲁食物成瘾量表对家庭医学和肥胖门诊收治的肥胖和非肥胖患者进行调查。正态分布数据的显著性差异采用t检验,非正态分布数据的显著性差异采用Mann-Whitney U检验。分类数据以百分比表示。采用建立的二元logistic回归模型确定食物成瘾与年龄、BMI、性别、吸烟状况之间的关系,以及性别、吸烟、食物成瘾和肥胖之间的关系。P
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引用次数: 0
Learning Needs of Bariatric Surgery Patients: A Qualitative Study 减肥手术患者的学习需求:一项定性研究
Pub Date : 2022-12-29 DOI: 10.25048/tudod.1116507
H. Bozdemir, Züleyha ŞİMŞEK YABAN, S. Güler, Z. Utkan
Aim: This study was planned to determine the training needs that patients who experienced bariatric surgery patients should receive from health professionals. Material and Methods: The research was planned using a qualitative research methods. The study was conducted with 13 patients in a university hospital between April 2020 and July 2020. Research data was collected using a Semi-Structured Interview form and patient socio-demographic form. The data analysis method was used with MAXQDA 2020-Qualitative data Analyses program, Colaizzi's 7-step analysis process. Results: We five main themes related to the learning needs of patients who have undergone bariatric surgery were determined as; “Physiological Requirements, Psychological Requirements, Social requirements, Consulting requirements and Learning methods”. Conclusion: It was determined that the patients had the highest learning needs on postoperative nutrition, complications, surgical procedure, symptoms, daily life activities, mobilization, adapting to the social life, learning materials, to come together with the people experiencing the process of bariatric surgery, etc. in the codes and sub-codes created from the patient expressions. Patients undergoing bariatric surgery need continuous, easily accessible, applicable, and emotional support to prevent complications before and after the surgery, to make behavioral changes and prevent weight gain.
目的:本研究旨在确定经历过减肥手术的患者应该从健康专业人员那里接受的培训需求。材料与方法:本研究采用定性研究方法。该研究于2020年4月至2020年7月在一所大学医院对13名患者进行了研究。研究数据采用半结构化访谈表和患者社会人口统计表收集。数据分析方法采用MAXQDA 2020-Qualitative data Analyses program, Colaizzi’s 7-step analysis process。结果:我们确定了与减肥手术患者学习需求相关的五个主要主题为;“生理要求、心理要求、社会要求、咨询要求、学习方法”。结论:从患者表情创建的码和子码中,确定患者对术后营养、并发症、手术程序、症状、日常生活活动、动员、适应社会生活、学习材料、与经历减肥手术过程的人在一起等方面的学习需求最高。接受减肥手术的患者需要持续的、容易获得的、适用的和情感上的支持,以防止手术前后的并发症,改变行为,防止体重增加。
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引用次数: 0
Evaluation of First Trimester Fasting Blood Glucose, HOMA-IR and HbA1c in Prediction of Gestational Diabetes Mellitus in Non-Obese Pregnant Women: A Retrospective Study 非肥胖孕妇妊娠早期空腹血糖、HOMA-IR和HbA1c预测妊娠糖尿病的回顾性研究
Pub Date : 2022-12-29 DOI: 10.25048/tudod.1198697
M. Kırlangıç, B. N. Arıcı Halıcı
Aim: Gestational Diabetes Mellitus (GDM) is the most common endocrine complication in pregnancy with fetomaternal comorbidities. It is aimed to evaluate fasting blood glucose (FBG), homeostasis model assessment of insulin resistance (HOMA-IR), and hemoglobin A1c (HbA1c) values in the first trimester in non-obese pregnant women for early detection of GDM. Material and Methods: Pregnant women with first-trimester FBG, HOMA-IR, HbA1c values, and second-trimester OGTT results were scanned from the hospital database. First-trimester height, weight, age and gestational weeks were also recorded. The presence of Body Mass Index (BMI) over 30 kg/m2, chronic and systemic disease and history of G(DM) were not included in the study. ROC analysis was performed on FBG, HOMA-IR, and HbA1c. Results: This retrospective study was conducted between 01/01/2021, and 01/01/2022 in Tuzla State Hospital Gynecology and Obstetrics Clinic. 131 pregnant women who met the inclusion criteria were reached. Twenty of pregnant women were evaluated as GDM positive(+). Age, height, weight, BMI, gestational week, and nulliparity were observed to be similar between the groups. FBG, insulin, HOMA-IR, and HbA1c values were higher in the group with GDM. As a result of ROC analysis, those with an FBG value of 88,5 mg/dl (sensitivity 68.2%, specificity 68.2%), a HOMA-IR value of 2.24 (sensitivity 63.6%, specificity 64.5%), and a HbA1c (sensitivity 68.2%, specificity 66.7%) value of over 5.25% were observed to be at risk for GDM. Conclusion: It has shown that pregnant women with high first trimester FBG, HOMA-IR and HbA1c have a high risk for GDM and can be used as a predictor of GDM.
目的:妊娠期糖尿病(GDM)是妊娠期最常见的内分泌并发症,并伴有胎母合并症。该研究旨在评估非肥胖孕妇妊娠早期的空腹血糖(FBG)、胰岛素抵抗稳态模型评估(HOMA-IR)和血红蛋白A1c (HbA1c)值,以便早期发现GDM。材料和方法:从医院数据库中扫描妊娠早期FBG、HOMA-IR、HbA1c值和妊娠中期OGTT结果的孕妇。还记录了孕早期的身高、体重、年龄和孕周。体重指数(BMI)超过30 kg/m2、慢性和全身性疾病以及G(DM)病史均未纳入研究。对FBG、HOMA-IR和HbA1c进行ROC分析。结果:本回顾性研究于2021年1月1日至2022年1月1日在图兹拉州立医院妇产科诊所进行,共纳入131名符合纳入标准的孕妇。20例孕妇GDM阳性(+)。年龄、身高、体重、身体质量指数、妊娠周数和无产率在两组之间相似。GDM组的FBG、胰岛素、HOMA-IR和HbA1c值较高。ROC分析结果显示,FBG值为88.5 mg/dl(敏感性68.2%,特异性68.2%)、HOMA-IR值为2.24(敏感性63.6%,特异性64.5%)、HbA1c(敏感性68.2%,特异性66.7%)值超过5.25%的患者为GDM高危人群。结论:孕早期FBG、HOMA-IR、HbA1c较高的孕妇发生GDM的风险较高,可作为GDM的预测指标。
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引用次数: 2
Tip 1 Diyabetli Çocuklarda Kardiyak Fonksiyonlar ile Karotis İntima Media Kalınlığının Değerlendirilmesi
Pub Date : 2022-12-29 DOI: 10.25048/tudod.1152686
Veli Akkurt, Mehmet Fatih Deveci, Osman Başpınar, Mehmet Keskin
Amaç: Tip 1 Diyabetes Mellitus (DM) tanısı ile izlenen çocuklarda, karotis intima media kalınlığı (KİMK), sol kardiyak sistolik ve diyastolik fonksiyonları ekokardiyografik yöntem ile değerlendirmek. Gereç ve Yöntemler: Üniversitemizde en az 4 yıldır tip 1 DM tanısı ile izlenen 31 hasta ve kontrol grubu olarak 19 sağlıklı çocuk çalışmaya alınmıştır. Hastalar; glisemik kontrol düzeyleri, hastalık süreleri ve cinsiyetlerine göre gruplandırılarak, kontrol grubuyla karşılaştırıldı. SPSS for Windows version 17.0 paket programı kullanılarak istatistiksel analizler yapıldı. Bulgular: Hasta ve kontrol grubu; yaş, boy, cinsiyet, ağırlık, vücut kütle indeksi, sistolik ve diyastolik kan basıncı bakımından benzerdi (p>0.05). Diyabetli hastalar ve kontrol grubu, kardiyak sistolik ve diyastolik fonksiyonlar, KİMK değerleri arasında anlamlı bir fark yoktu (p>0.05). Hastalar diyabet sürelerine göre ve glisemik kontrole göre alt gruplara ayrıldığında KİMK düzeyleri arasında anlamlı bir fark bulunamadı (sırasıyla, p=0.084 ve p=0.410). DM süresi ≥8 yıl olan hastalarda KİMK 0.54 mm olarak istatistiksel anlamlı olmasa da belirgin artmış olarak bulundu. Alt grup analizinde diyabetik erkeklerde, kontrol grubu erkeklere ve diyabetik kızlara göre sol KİMK anlamlı olarak artmış olarak bulundu (sırasıyla, p=0.026 ve p=0.022). Diyabetik erkeklerde ortalama KİMK kız grubuna göre anlamlı fark saptandı (p=0.042). Sonuç: Diyabetik erkeklerde artış gösteren ortalama ve sol KİMK, ateroskleroz açısından cinsiyetin bağımsız bir risk faktörü olabileceğini düşündürdü. Yoğun diyabet tedavisi ve glisemik kontrolüne rağmen Tip 1 DM özellikle erkek cinsiyette çocukluk çağında dahi kardiyovasküler sistemi etkileyen önemli bir risk faktörüdür.
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引用次数: 0
The Emerging Roles of MicroRNAs as Biomarkers in Diabetic Nephropathy microrna作为糖尿病肾病生物标志物的新作用
Pub Date : 2022-12-29 DOI: 10.25048/tudod.1111845
Destan Kalacay, A. Hacışevki
Diabetic nephropathy (DN) is one of the most common complications of diabetes mellitus (DM), as well as the most common health issue among End Stage Renal Diseases (ESRD). Recent studies have shown that this concern will likely to become a global phenomenon in the future. Early diagnosis of DN is vital for its treatment. MicroRNAs (miRNAs or miRs) are the most promising for new biomarker candidates proposed for DN. MiRNAs, known as non protein-coding short-chain RNA sequences, have a regulatory role in many cellular events. Advances in molecular genetics and successful genomic techniques allow miRNAs to be used in the diagnosis of several diseases. As the DN diagnostic markers used today are insufficient for some cases, identifying new diagnostic markers is the basis of recent studies. Successful use of miRNAs in the areas of cancer, immunity and diabetes indicates that the DN perspective should be based on miRNA. In this review, miRNAs and their role in DN will be reviewed.
糖尿病肾病(DN)是糖尿病(DM)最常见的并发症之一,也是终末期肾病(ESRD)中最常见的健康问题。最近的研究表明,这种担忧在未来可能会成为一种全球现象。DN的早期诊断对其治疗至关重要。MicroRNAs (miRNAs或miRs)是最有希望的DN新生物标志物候选物。mirna被称为非蛋白质编码短链RNA序列,在许多细胞事件中具有调节作用。分子遗传学的进步和成功的基因组技术使mirna可用于多种疾病的诊断。由于目前使用的DN诊断标记物在某些情况下是不够的,寻找新的诊断标记物是最近研究的基础。miRNA在癌症、免疫和糖尿病领域的成功应用表明,DN的视角应该基于miRNA。本文将对mirna及其在DN中的作用进行综述。
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引用次数: 0
Diyabetik Retinopatili Hastalarda Sağlıkla İlişkili Yaşam Kalitesini Etkileyen Faktörlerin Değerlendirilmesi
Pub Date : 2022-12-29 DOI: 10.25048/tudod.1127641
Ahmet Sakallioğlu, İrfan Akaray, Sultan Kaya, Ö. Kaya, Gizem Köse, Rüveyde Gari̇p, Hande Guclu
Amaç: Diyabetik retinopati (DRP) hastalarında sağlıkla ilişkili yaşam kalitesini (SİYK) etkileyen faktörlerin araştırılması. Gereç ve Yöntemler: Çalışmaya tip 2 diyabet nedeniyle DRP açısından takipli 400 hastanın 800 gözü katılmıştır. Hastalar oftalmolojik muayene sonrasında Kısa Form-36 (SF-36) anketini doldurmuştur. SF-36’ya göre fiziksel işlev, fiziksel rol, bedensel ağrı, genel sağlık, canlılık, sosyal işlevsellik, duygusal rol ve ruh sağlığı, fiziksel ve zihinsel bileşen özet ölçümleri hesaplandı. Hastaların demografik özellikleri hasta dosyalarından not edilmiştir. İki bağımsız grubu karşılaştırmak için normal dağılım varsayıldığında bağımsız örneklemlerde T-testi, verilerin normalliği reddedildiğinde Mann-Whitney U testi kullanıldı. İkiden fazla olan bağımsız grupların karşılaştırılmasında Bonferroni veya Tamhane’s T2 düzeltmeli ANOVA testi, sayısal değişkenler arasındaki ilişki Pearson korelasyon testi ile değerlendirildi. Anlamlılık düzeyi p
目的:研究影响糖尿病视网膜病变患者健康相关生活质量(HRQoL)的因素:研究影响糖尿病视网膜病变(DRP)患者健康相关生活质量(HRQoL)的因素。材料与方法:研究对象包括 400 名 2 型糖尿病视网膜病变患者的 800 只眼睛。患者在眼科检查后填写了简表-36(SF-36)问卷。根据 SF-36,计算了身体功能、身体角色、身体疼痛、一般健康、活力、社会功能、情感角色和心理健康、身体和心理部分的汇总测量值。从患者档案中记录了患者的人口统计学特征。在假定数据呈正态分布的情况下,采用独立样本 T 检验比较两个独立组别;在拒绝接受数据正态性的情况下,采用曼-惠特尼 U 检验。对两个以上的独立组进行比较时,采用 Bonferroni 或 Tamhane's T2 校正方差分析检验,数字变量之间的关系采用皮尔逊相关检验进行评估。显著性水平 p
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引用次数: 0
Given According to Knowledge, Motivation and Behavioral Skills (IMB Model) The Effect of Diabetes Education on Self-Care 基于知识、动机和行为技能(IMB模型)的糖尿病教育对自我护理的影响
Pub Date : 2022-12-29 DOI: 10.25048/tudod.1149785
B. Inkaya, Tuba Yılmazer, Hilal Tüzer, E. Erbil
Aim: It has been determined that the education given according to the information, motivation, and behaviour model is effective in AIDS, chronic diseases, glucose control in diabetes, and self-care behaviours such as diet and exercise. The aim of this study, which is planned from this point of view, is to evaluate the effect of education given according to the information, motivation, and behaviour model on diabetic self-care management. Material and Methods: This study was conducted as an experimental study with a nonrandomized control group that included 90 diabetes mellitus individuals, with 45 in the intervention group and 45 in the control group. The control group were given formal diabetes mellitus education. In contrast, the intervention group received an education based on the information, motivation, and behaviour model and diabetes mellitus cases were followed for six months. Data were collected with a questionnaire on the essential characteristics of the patients, an evaluation form on the level of knowledge about diabetes, an evaluation form on their motivation about diabetes, and a diabetes self-care activities questionnaire. An Independent Sample-t test was used to analyze the data, and Paired Sample-test statistics were used to compare two dependent groups. Mann-Whitney U test was used to compare the measurement values of two independent groups that did not have a normal distribution. Wilcoxon test statistics were used to compare two dependent groups. Results: At the end of the study, it was determined that while HbA1c in the intervention group decreased for 6 months, knowledge scores, motivation levels and self-care skill scores increased (t=7.067, p
目的:已经确定,根据信息、动机和行为模式进行的教育对艾滋病、慢性病、糖尿病患者的血糖控制以及饮食和运动等自我保健行为是有效的。从这个角度出发,本研究的目的是评估根据信息、动机和行为模型进行的教育对糖尿病自我保健管理的效果。材料与方法:本研究为实验性研究,采用非随机对照组,90例糖尿病患者,干预组45例,对照组45例。对照组给予正规的糖尿病教育。干预组接受基于信息、动机和行为模式的教育,糖尿病患者随访6个月。采用患者基本特征问卷、糖尿病知识水平评估表、糖尿病动机评估表和糖尿病自我护理活动问卷收集数据。采用独立样本t检验对数据进行分析,采用配对样本检验统计量对两相关组进行比较。采用Mann-Whitney U检验比较两个非正态分布的独立组的测量值。采用Wilcoxon检验统计量对两个依赖组进行比较。结果:研究结束时,在干预组HbA1c下降6个月的同时,知识得分、动机水平和自我护理技能得分均有所提高(t=7.067, p . 796)
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引用次数: 0
VI. ZONGULDAK ENDOKRİN GÜNLERİ III. ENDOKRİNOLOJİK HASTALIKLARA MULTİDİSİPLİNER GÜNCEL YAKLAŞIM KONGRESİ BİLİMSEL PROGRAM, SÖZLÜ VE POSTER BİLDİRİLERİ
Pub Date : 2022-12-29 DOI: 10.25048/tudod.1187443
Taner Bayraktaroğlu, Güldeniz KARADENİZ ÇAKMAK, Ömercan Topaloğlu, Hakan Balbaloğlu
Zonguldak Bulent Ecevit Universitesi Merkez Farabi Kampusu Tahir Karauğuz Konferans Salonu ve Sezai Karakoc Kultur Merkezi’nde, Prof.Dr.Taner BAYRAKTAROĞLU ve Prof.Dr.Güldeniz Karadeniz ÇAKMAK’ın Kongre başkanlıklarıyla, 20 Eylul – 24 Eylul 2022 tarihlerinde “VI. Zonguldak Endokrin Gunleri, Endokrin Hastalıklara Multidisipliner Guncel Yaklaşım Kongresi (https://zeg.beun.edu.tr/)” gercekleştirildi. Kongre oturumlarındaki olgu sunumlarının, sözlü bildirileri ve poster bildirileri ozetlerinin sunulması amaçlanmıştır. Kongre suresince iki ayrı oturumda toplam 16 sözel bildiri ve poster bildirisi yapıldı. Boylece, Kongrede gercekleştirilen endokrin hastalıklara guncel yaklaşımın bilim dunyası ile paylaşılması sağlanmıştır. Anahtar Sözcükler: Zonguldak Endokrin Gunleri, Endokrin Hastalıklar, Multidisipliner Yaklaşım, Kongre
由Taner BAYRAKTAROĞLU教授和Güldeniz Karadeniz ÇAKMAK教授担任大会主席的 "VI. Zonguldak Endocrine Days, Multidisciplinary Current Approach to Endocrine Diseases Congress (https://zeg.beun.edu.tr/) "于2022年9月20日至9月24日在Zonguldak Bulent Ecevit University Central Farabi Campus Tahir Karauğuz会议厅和Sezai Karakoc Kultur Center举行。大会旨在通过病例报告、口头报告和海报摘要等形式进行展示。大会期间,共有 16 个口头报告和墙报展示分两场进行。因此,大会确保了与科学界分享当前治疗内分泌疾病的方法。 关键词宗古尔达克内分泌日、内分泌疾病、多学科方法、大会
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引用次数: 0
期刊
Turkish Journal of Diabetes and Obesity
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