Pub Date : 2024-07-15DOI: 10.18231/j.ijpca.2024.017
Joshi Ankur, S. Priyanka, Malviya Neelesh, Malviya Sapna, Kharia Anil
Researchers from a variety of disciplines are investigating the use of extracellular vesicles (EVs) as delivery vehicles for pharmaceutical solutions. In order to make the most of the therapeutic potential of EVs, various loading strategies have been devised. Despite the widespread application of exogenous methods, endogenous approaches are becoming increasingly preferred instead. Medicinal macro molecules such as proteins and nucleic acids can be loaded with relative ease using this technology that manipulates parental cells through genetic engineering. We examine the most effective ways for EV loading and demonstrate why endogenous is superior. Extracellular vesicles (EVs), which are able to transport pharmaceuticals, have the potential to tackle the problems of biologic therapeutic stability and off-target undesirable effects. In addition, we investigate the most recent findings and applications of this innovative method in order to shed light on the numerous potential therapeutic possibilities in the field of EV-based treatments. The possibility of endogenous loading of EVs with big biological medicines has been brought to light by recent research. In order to optimize the loading of biologic drugs in extracellular vesicles (EVs), researchers have been able to apply cargo selection and loading pathway molecules thanks to advancements in EV biogenesis. It has been established that endogenous EV loading is successful in preclinical in vivo trials, which demonstrates its promise in a variety of therapeutic situations.
来自不同学科的研究人员正在研究如何利用细胞外囊泡 (EVs) 作为药液的输送载体。为了充分利用细胞外囊泡的治疗潜力，人们设计了各种装载策略。尽管外源性方法得到了广泛应用，但内源性方法却越来越受到青睐。利用这种通过基因工程操纵母细胞的技术，可以相对容易地装载蛋白质和核酸等药用大分子。我们研究了装载细胞外囊泡的最有效方法，并说明了为什么内源性技术更胜一筹。细胞外囊泡 (EV) 能够运输药物，具有解决生物治疗稳定性和脱靶不良反应问题的潜力。此外，我们还调查了这一创新方法的最新发现和应用，以揭示基于 EV 的治疗领域的众多潜在治疗可能性。最近的研究发现，EVs 可内源性负载大型生物药物。为了优化细胞外囊泡（EVs）中生物药物的负载，研究人员已经能够应用货物选择和负载路径分子，这要归功于 EV 生物发生的进步。在临床前的体内试验中，内源性 EV 负载已被证实是成功的，这证明了它在各种治疗情况下的应用前景。
{"title":"Extracellular vesicles the delivery of drugs through genetic engineering","authors":"Joshi Ankur, S. Priyanka, Malviya Neelesh, Malviya Sapna, Kharia Anil","doi":"10.18231/j.ijpca.2024.017","DOIUrl":"https://doi.org/10.18231/j.ijpca.2024.017","url":null,"abstract":"Researchers from a variety of disciplines are investigating the use of extracellular vesicles (EVs) as delivery vehicles for pharmaceutical solutions. In order to make the most of the therapeutic potential of EVs, various loading strategies have been devised. Despite the widespread application of exogenous methods, endogenous approaches are becoming increasingly preferred instead. Medicinal macro molecules such as proteins and nucleic acids can be loaded with relative ease using this technology that manipulates parental cells through genetic engineering. We examine the most effective ways for EV loading and demonstrate why endogenous is superior. Extracellular vesicles (EVs), which are able to transport pharmaceuticals, have the potential to tackle the problems of biologic therapeutic stability and off-target undesirable effects. In addition, we investigate the most recent findings and applications of this innovative method in order to shed light on the numerous potential therapeutic possibilities in the field of EV-based treatments. The possibility of endogenous loading of EVs with big biological medicines has been brought to light by recent research. In order to optimize the loading of biologic drugs in extracellular vesicles (EVs), researchers have been able to apply cargo selection and loading pathway molecules thanks to advancements in EV biogenesis. It has been established that endogenous EV loading is successful in preclinical in vivo trials, which demonstrates its promise in a variety of therapeutic situations.","PeriodicalId":14182,"journal":{"name":"International Journal of Pharmaceutical Chemistry and Analysis","volume":" 44","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141832912","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-07-15DOI: 10.18231/j.ijpca.2024.021
Madhuri Dalavi, Sakshi Handge, Vaishnavi Pate, Hemant Raut, Amit V. Kakad, M.R.N Shaikh
There are currently worldwide efforts to reduce sugar intake due to various adverse health effects linked with the overconsumption of sugar. Natural sweeteners have been used as an alternative to artificial sweeteners, nutritive sugar for numerous applications. However, their long-term effects on human health remain. Thaumatin is a class of sweet proteins found in West African plants from the arils of Thaumatococcus daniellii. The article reviews the Thaumatin Morphology, Collection time, Extraction, Bio-production, Bio-transformation, Properties like sensory properties, Characteristics of plants ie Sweetness, Composition, Isolation process, Mode of action, Binding site of the receptor, Applications, Uses and overall safety aspects of Thaumatin is known as sweetest compound till the date.
{"title":"Fundamental overview and applicability of thaumatin","authors":"Madhuri Dalavi, Sakshi Handge, Vaishnavi Pate, Hemant Raut, Amit V. Kakad, M.R.N Shaikh","doi":"10.18231/j.ijpca.2024.021","DOIUrl":"https://doi.org/10.18231/j.ijpca.2024.021","url":null,"abstract":"There are currently worldwide efforts to reduce sugar intake due to various adverse health effects linked with the overconsumption of sugar. Natural sweeteners have been used as an alternative to artificial sweeteners, nutritive sugar for numerous applications. However, their long-term effects on human health remain. Thaumatin is a class of sweet proteins found in West African plants from the arils of Thaumatococcus daniellii. The article reviews the Thaumatin Morphology, Collection time, Extraction, Bio-production, Bio-transformation, Properties like sensory properties, Characteristics of plants ie Sweetness, Composition, Isolation process, Mode of action, Binding site of the receptor, Applications, Uses and overall safety aspects of Thaumatin is known as sweetest compound till the date.","PeriodicalId":14182,"journal":{"name":"International Journal of Pharmaceutical Chemistry and Analysis","volume":" 41","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141833322","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-07-15DOI: 10.18231/j.ijpca.2024.014
T. Basuri, Ranjit Mohapatra, N. Dhal, S. N. Kharat
This review article include study on plants used by different tribes of different districts of Odisha for the treatment of Liver disease. A Field work was carried out the months of June – July 2016. The ethano-medicinal survey was conducted particularly with Odisha tribes in different districts having forest pockets with the help of local medicine men, locally known as Ayurveda. Data were collected through structure questionnaires and observing during the field visits. In the present study the local population used a total of 20 plant species belonging to 10 families to cure a variety of diseases. Out of the 20 plants,12 was herb, followed by trees and shrubs. The present study concluded that, the Odisha tribes of the study area possess rich knowledge on the medicinal plants and their utilization. Thus, the present study focuses on the documentation of the traditional knowledge of these valuable plants, which could enhance the potential of these medicinal plants to other communities as well and by understanding the importance, other communities can also helpful for conservation of these resources for further use.
{"title":"A meta analysis study on plants used by tribes of various districts of Odisha for treatment of liver disease","authors":"T. Basuri, Ranjit Mohapatra, N. Dhal, S. N. Kharat","doi":"10.18231/j.ijpca.2024.014","DOIUrl":"https://doi.org/10.18231/j.ijpca.2024.014","url":null,"abstract":"This review article include study on plants used by different tribes of different districts of Odisha for the treatment of Liver disease. A Field work was carried out the months of June – July 2016. The ethano-medicinal survey was conducted particularly with Odisha tribes in different districts having forest pockets with the help of local medicine men, locally known as Ayurveda. Data were collected through structure questionnaires and observing during the field visits. In the present study the local population used a total of 20 plant species belonging to 10 families to cure a variety of diseases. Out of the 20 plants,12 was herb, followed by trees and shrubs. The present study concluded that, the Odisha tribes of the study area possess rich knowledge on the medicinal plants and their utilization. Thus, the present study focuses on the documentation of the traditional knowledge of these valuable plants, which could enhance the potential of these medicinal plants to other communities as well and by understanding the importance, other communities can also helpful for conservation of these resources for further use.","PeriodicalId":14182,"journal":{"name":"International Journal of Pharmaceutical Chemistry and Analysis","volume":" 14","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141833386","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-07-15DOI: 10.18231/j.ijpca.2024.016
Shilpi Arora, Anubhav Dubey, Mamta Kumari
Digital fabrication technology, often known as 3D printing or additive manufacturing, constructs tangible items by incrementally adding materials based on a geometric model. 3D printing technology is a rapidly advancing technology. Currently, 3D printing finds extensive use worldwide. The agricultural, healthcare, automobile, locomotive, and aviation sectors are increasingly utilising 3D printing technology for mass customisation and manufacturing of various open-source designs. 3D printing technology enables the sequential addition of material layers to create an item directly from a computer-assisted design (CAD) model. This article provides an overview of several kinds of 3D printing methods, their applications, and the materials used in the manufacturing business.Additive manufacturing, 3D Printing, Manufacturing industry
数字制造技术通常被称为三维打印或快速成型技术，它通过在几何模型的基础上逐步添加材料来制造有形物品。三维打印技术是一项发展迅速的技术。目前，3D 打印技术在全球范围内得到广泛应用。农业、医疗保健、汽车、机车和航空领域正越来越多地利用 3D 打印技术来大规模定制和制造各种开源设计。三维打印技术可按顺序添加材料层，直接根据计算机辅助设计（CAD）模型创建物品。本文概述了几种 3D 打印方法、其应用以及制造业务中使用的材料。
{"title":"The role of 3- D printing technologies","authors":"Shilpi Arora, Anubhav Dubey, Mamta Kumari","doi":"10.18231/j.ijpca.2024.016","DOIUrl":"https://doi.org/10.18231/j.ijpca.2024.016","url":null,"abstract":"Digital fabrication technology, often known as 3D printing or additive manufacturing, constructs tangible items by incrementally adding materials based on a geometric model. 3D printing technology is a rapidly advancing technology. Currently, 3D printing finds extensive use worldwide. The agricultural, healthcare, automobile, locomotive, and aviation sectors are increasingly utilising 3D printing technology for mass customisation and manufacturing of various open-source designs. 3D printing technology enables the sequential addition of material layers to create an item directly from a computer-assisted design (CAD) model. This article provides an overview of several kinds of 3D printing methods, their applications, and the materials used in the manufacturing business.Additive manufacturing, 3D Printing, Manufacturing industry","PeriodicalId":14182,"journal":{"name":"International Journal of Pharmaceutical Chemistry and Analysis","volume":" 82","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141833756","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-03-15DOI: 10.18231/j.ijpca.2024.010
F. Obed, Shatha M. J. Al-Khateeb, Raghada Shams Akram, Mohammad Ali Kareem
This study is aimed to put light on the effect of vitamin D3 (VitD3) in newly diagnosed acute myeloid leukemia (AML) patients. The AML patients consisted of sixty patients (30 male, 30 female). The average age of patients was (36.44±8.44) years (range 25-45). Thirty healthy subjects were considered as controls (15 male and 15 female), and the average age of control group was (32.22±5.13) years. All subjects had to go through clinical examination to determine existence of other diseases in addition to evaluate some tests as complete blood count [hemoglobin (Hb), platelet (PLT), and white blood cells (WBCs)], ferritin, FBS (fasting blood sugar), TG (triglycerides), TC (total cholesterol), and HDL (high density lipoprotein cholesterol) (HDL-Ch), urea, and creatinine. Vitamin D3 was measured by minividase Biomerux/French. The VitD3 was highly significantly lower in AML patients than in controls (p=0.001). While, VitD3 was lower in male than in female AML patients but the difference was not statistically significant. There were statistically significant positive correlations between VitD3 and Hb, PLT, Wbc, ferritin, FBS, and TG in both male and female AML patients. These findings suggest that lower serum concentrations of vitamin D3 may possibly be considered as a potential factor for early assessment of acute myeloid leukemia.
{"title":"Study the effect of Vitamin D3 in newly diagnosed acute myeloid leukemia","authors":"F. Obed, Shatha M. J. Al-Khateeb, Raghada Shams Akram, Mohammad Ali Kareem","doi":"10.18231/j.ijpca.2024.010","DOIUrl":"https://doi.org/10.18231/j.ijpca.2024.010","url":null,"abstract":"This study is aimed to put light on the effect of vitamin D3 (VitD3) in newly diagnosed acute myeloid leukemia (AML) patients. The AML patients consisted of sixty patients (30 male, 30 female). The average age of patients was (36.44±8.44) years (range 25-45). Thirty healthy subjects were considered as controls (15 male and 15 female), and the average age of control group was (32.22±5.13) years. All subjects had to go through clinical examination to determine existence of other diseases in addition to evaluate some tests as complete blood count [hemoglobin (Hb), platelet (PLT), and white blood cells (WBCs)], ferritin, FBS (fasting blood sugar), TG (triglycerides), TC (total cholesterol), and HDL (high density lipoprotein cholesterol) (HDL-Ch), urea, and creatinine. Vitamin D3 was measured by minividase Biomerux/French. The VitD3 was highly significantly lower in AML patients than in controls (p=0.001). While, VitD3 was lower in male than in female AML patients but the difference was not statistically significant. There were statistically significant positive correlations between VitD3 and Hb, PLT, Wbc, ferritin, FBS, and TG in both male and female AML patients. These findings suggest that lower serum concentrations of vitamin D3 may possibly be considered as a potential factor for early assessment of acute myeloid leukemia.","PeriodicalId":14182,"journal":{"name":"International Journal of Pharmaceutical Chemistry and Analysis","volume":" 72","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140392048","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-03-15DOI: 10.18231/j.ijpca.2024.009
Vinay V. Sarode, Sadhana P. Gautam
Hair has historically been associated with beauty and a person's unique personality. Numerous elements, including metabolism, hormones, inheritance, and the adverse effects of immunosuppressive and anti-neoplastic medications, can adversely impact hair health and lead to hair loss, or alopecia. It is typical everywhere in the world.The current study examined the effect of betulin for hair growth promoting activity in rats.The study used 48 albino wistar rats, weighing 200 ± 30 grams and aged between 12 and 16 months. Testosterone was given at a dose of 0.5 mg/kg to induce hair loss. During 28 days, a once-daily topical application of minoxidil solution was made. On a daily basis for 28 days, betulin was administered orally at concentrations of 10 mg/kg, 20 mg/kg, and 40 mg/kg. A combination of Betulin (10 mg/kg p.o.) and 3% Minoxidil was administered to one group, while the other was treated with Topical Betulin Solution (3 mg/ml once daily for 28 days). ANOVA analysis was used to ascertain the data's statistic.The results showed that effect of Betulin on Alopecia as evidenced by decreased levels of cholesterol, testosterone and increased levels of Hair length.According to the current study, albino wistar rats with Testosterone induced Alopecia can benefit from treatment with an Betulin.
{"title":"Evaluation of betulin for hair growth promoting activity in rats","authors":"Vinay V. Sarode, Sadhana P. Gautam","doi":"10.18231/j.ijpca.2024.009","DOIUrl":"https://doi.org/10.18231/j.ijpca.2024.009","url":null,"abstract":"Hair has historically been associated with beauty and a person's unique personality. Numerous elements, including metabolism, hormones, inheritance, and the adverse effects of immunosuppressive and anti-neoplastic medications, can adversely impact hair health and lead to hair loss, or alopecia. It is typical everywhere in the world.The current study examined the effect of betulin for hair growth promoting activity in rats.The study used 48 albino wistar rats, weighing 200 ± 30 grams and aged between 12 and 16 months. Testosterone was given at a dose of 0.5 mg/kg to induce hair loss. During 28 days, a once-daily topical application of minoxidil solution was made. On a daily basis for 28 days, betulin was administered orally at concentrations of 10 mg/kg, 20 mg/kg, and 40 mg/kg. A combination of Betulin (10 mg/kg p.o.) and 3% Minoxidil was administered to one group, while the other was treated with Topical Betulin Solution (3 mg/ml once daily for 28 days). ANOVA analysis was used to ascertain the data's statistic.The results showed that effect of Betulin on Alopecia as evidenced by decreased levels of cholesterol, testosterone and increased levels of Hair length.According to the current study, albino wistar rats with Testosterone induced Alopecia can benefit from treatment with an Betulin.","PeriodicalId":14182,"journal":{"name":"International Journal of Pharmaceutical Chemistry and Analysis","volume":" 6","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140391553","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-03-15DOI: 10.18231/j.ijpca.2024.005
A. Panwar, Priyanka Rathore
The skin serves as the primary barrier protecting the body from external insults, and its integrity is crucial for overall health. Formulation excipients, including emulsifiers, thickeners, and preservatives, commonly used in skincare products, can significantly influence skin barrier function and permeability. This review evaluates the impact of these Excipients on skin barrier function using biophysical measurements such as Trans-epidermal Water Loss (TEWL), skin hydration, and trans-epidermal water content. Furthermore, it discusses the potential implications of excipient-induced alterations in skin barrier function for skin health and tolerability.
{"title":"Impact of formulation excipients on skin barrier functions: A review","authors":"A. Panwar, Priyanka Rathore","doi":"10.18231/j.ijpca.2024.005","DOIUrl":"https://doi.org/10.18231/j.ijpca.2024.005","url":null,"abstract":"The skin serves as the primary barrier protecting the body from external insults, and its integrity is crucial for overall health. Formulation excipients, including emulsifiers, thickeners, and preservatives, commonly used in skincare products, can significantly influence skin barrier function and permeability. This review evaluates the impact of these Excipients on skin barrier function using biophysical measurements such as Trans-epidermal Water Loss (TEWL), skin hydration, and trans-epidermal water content. Furthermore, it discusses the potential implications of excipient-induced alterations in skin barrier function for skin health and tolerability.","PeriodicalId":14182,"journal":{"name":"International Journal of Pharmaceutical Chemistry and Analysis","volume":" 13","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140391441","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-03-15DOI: 10.18231/j.ijpca.2024.004
R. Chakraverty, Jyotirmoy Bondyopadhyay, Tatini Debnath
Amyloid-β (Aβ) peptide accumulation in the brain, leading to amyloid plaques, is considered to be the starting point of Alzheimer's disease. It is believed that these plaques impair cognitive and functional capacities and induce neurodegeneration. Research on uncommon genetic variants that either increase or decrease the quantity of Aβ deposited offers proof that amyloid plaques are involved in the disease's progression. Early-stage amyloid plaque buildup increases the likelihood that moderate cognitive impairment may progress to dementia.Donanemab, a humanized IgG1 antibody, targets an N-terminal pyroglutamate Aβ epitope that is unique to plaques that have already begun to develop. It is specific to this epitope and has no known clinical effect. Furthermore, it doesn't show any off-target binding to neurotransmitters, their receptors, or other Aβ species. In this systematic review, we first collect the necessary information after carefully reviewing four different study articles. After the data is collected, we evaluate it and create a graph to compare those study articles.
{"title":"Prospective role of Donanemab and amyloid beta therapies in early Alzheimer’s disease: A systematic review","authors":"R. Chakraverty, Jyotirmoy Bondyopadhyay, Tatini Debnath","doi":"10.18231/j.ijpca.2024.004","DOIUrl":"https://doi.org/10.18231/j.ijpca.2024.004","url":null,"abstract":"Amyloid-β (Aβ) peptide accumulation in the brain, leading to amyloid plaques, is considered to be the starting point of Alzheimer's disease. It is believed that these plaques impair cognitive and functional capacities and induce neurodegeneration. Research on uncommon genetic variants that either increase or decrease the quantity of Aβ deposited offers proof that amyloid plaques are involved in the disease's progression. Early-stage amyloid plaque buildup increases the likelihood that moderate cognitive impairment may progress to dementia.Donanemab, a humanized IgG1 antibody, targets an N-terminal pyroglutamate Aβ epitope that is unique to plaques that have already begun to develop. It is specific to this epitope and has no known clinical effect. Furthermore, it doesn't show any off-target binding to neurotransmitters, their receptors, or other Aβ species. In this systematic review, we first collect the necessary information after carefully reviewing four different study articles. After the data is collected, we evaluate it and create a graph to compare those study articles.","PeriodicalId":14182,"journal":{"name":"International Journal of Pharmaceutical Chemistry and Analysis","volume":" 43","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140391760","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-03-15DOI: 10.18231/j.ijpca.2024.013
S. Shaikh
The lip care product which we use for everyday purpose contain harmful metals and preservatives. Other than absorbing through the pores on your lips, these harmful chemicals and metals can lead to heart and brain diseases. Butylated compounds are generally used as preservatives in lip balm which can lead to cancer. Which are harmful to lips. Herbal lip balms are commonly used to avoid the problem which arise due to synthetic lip balm. Herbal lip balm is applied on the lips to prevent drying and protect us against the adverse environment. Herbal lip balm protects the lips from drying, chapping, inflammation, sores, cheilitis etc. these side effects can be reduced by using the medicated lip balms. These review article provide us a treatment for lips in the formulation of medicated lip balm. All ingredient used in the formulation are totally herbal and can reduce the chances of having lip disease.
{"title":"Beetroot powder loaded medicated lip balm","authors":"S. Shaikh","doi":"10.18231/j.ijpca.2024.013","DOIUrl":"https://doi.org/10.18231/j.ijpca.2024.013","url":null,"abstract":"The lip care product which we use for everyday purpose contain harmful metals and preservatives. Other than absorbing through the pores on your lips, these harmful chemicals and metals can lead to heart and brain diseases. Butylated compounds are generally used as preservatives in lip balm which can lead to cancer. Which are harmful to lips. Herbal lip balms are commonly used to avoid the problem which arise due to synthetic lip balm. Herbal lip balm is applied on the lips to prevent drying and protect us against the adverse environment. Herbal lip balm protects the lips from drying, chapping, inflammation, sores, cheilitis etc. these side effects can be reduced by using the medicated lip balms. These review article provide us a treatment for lips in the formulation of medicated lip balm. All ingredient used in the formulation are totally herbal and can reduce the chances of having lip disease.","PeriodicalId":14182,"journal":{"name":"International Journal of Pharmaceutical Chemistry and Analysis","volume":" 55","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140392462","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-03-15DOI: 10.18231/j.ijpca.2024.007
B. Premkumar, Samson Raj Yesuraj, Santhosh Mohan, Savitha Chandran
Approximately 80% of deaths attributable to skin cancer are attributed to melanoma. The main reason for its life-threatening nature is its high tendency to metastasis. The outlook for melanoma patients with distal metastases is grim, as they have a median survival of only six months, despite the utilization of the most advanced treatments now available. The Extracellular signal-regulated kinase (ERK) pathway is the most frequently altered oncogene in melanoma. Phytochemicals are receiving significant recognition due to their minimal toxicity, affordable price, and widespread acceptance as dietary supplements. Preclinical investigations have revealed many cellular and molecular processes via which phytochemicals function in the prevention and treatment of metastatic melanoma.: In this study, we performed virtual screening of 464 phytoconstituents were obtained from the Naturally Occurring Plant-based Anti-cancer Compound-Activity-Target (NPACT) database to identify novel ERK inhibitors.: Virtual screening carried out prediction of drug-likeness and molecular docking studies with 2OJG, protein target related to ERK pathway.: Nine compounds achieved better docking score as compared to co-crystallized ligand. The accuracy of the docking method was checked using re-docking. Picetannol and sulfurentin were identified as potential inhibitors with docking score of -9.2 and -8.2, respectively. These two phytoconstituents also found to be non-carcinogenic which was predicted using a free webtool, Swiss ADME.: Our finding suggests that Piceatannol has promising potential to be further explored as ERK-pathway inhibitor in treatment of melanoma
{"title":"Molecular docking studies for NPACT ligands for the treatment of melanoma skin cancer","authors":"B. Premkumar, Samson Raj Yesuraj, Santhosh Mohan, Savitha Chandran","doi":"10.18231/j.ijpca.2024.007","DOIUrl":"https://doi.org/10.18231/j.ijpca.2024.007","url":null,"abstract":"Approximately 80% of deaths attributable to skin cancer are attributed to melanoma. The main reason for its life-threatening nature is its high tendency to metastasis. The outlook for melanoma patients with distal metastases is grim, as they have a median survival of only six months, despite the utilization of the most advanced treatments now available. The Extracellular signal-regulated kinase (ERK) pathway is the most frequently altered oncogene in melanoma. Phytochemicals are receiving significant recognition due to their minimal toxicity, affordable price, and widespread acceptance as dietary supplements. Preclinical investigations have revealed many cellular and molecular processes via which phytochemicals function in the prevention and treatment of metastatic melanoma.: In this study, we performed virtual screening of 464 phytoconstituents were obtained from the Naturally Occurring Plant-based Anti-cancer Compound-Activity-Target (NPACT) database to identify novel ERK inhibitors.: Virtual screening carried out prediction of drug-likeness and molecular docking studies with 2OJG, protein target related to ERK pathway.: Nine compounds achieved better docking score as compared to co-crystallized ligand. The accuracy of the docking method was checked using re-docking. Picetannol and sulfurentin were identified as potential inhibitors with docking score of -9.2 and -8.2, respectively. These two phytoconstituents also found to be non-carcinogenic which was predicted using a free webtool, Swiss ADME.: Our finding suggests that Piceatannol has promising potential to be further explored as ERK-pathway inhibitor in treatment of melanoma","PeriodicalId":14182,"journal":{"name":"International Journal of Pharmaceutical Chemistry and Analysis","volume":" 9","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140392041","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
京公网安备 11010802042870号
京ICP备2023020795号-1
扫码关注我们
求助内容：
应助结果提醒方式：