Pub Date : 2024-03-15DOI: 10.18231/j.ijpca.2024.006
Manashri Yashwant Mokal, S. Shaikh
The most common intraocular tumor in children is retinoblastoma. In developed countries, there has been an impressive rise in the survival rate and visual outcome of patients with retinoblastoma. This is clarified by developments in retinoblastoma treatment and early detection of tumors. The primary therapy remedy for intraocular retinoblastoma is now chemotherapy along with adjuvant consolidative treatment, instead of external beam radiation. Likewise, prophylactic chemotherapy is now allowed to treat potential micro metastases in enucleated eyes based on the identification of high-risk histopathological factors. Extra ocular retinoblastoma still has a poor future outcome; chances of survival have been reported to be between 50% and 70%. Retinoblastoma patients' overall survival is still struggling in developing countries, mostly because of delayed presentation and greater risk of extra ocular illness while compared to with the developed world, where intraocular disease contributes to majority of cases. To enhance the survival rate for those with retinoblastoma in developing countries, greater priority must be given to early detection of tumors. We provide a summary of the latest clinical management of retinoblastoma in this article.
{"title":"Advancement in the treatment, genetic understanding, and diagnostic approaches for retinoblastoma","authors":"Manashri Yashwant Mokal, S. Shaikh","doi":"10.18231/j.ijpca.2024.006","DOIUrl":"https://doi.org/10.18231/j.ijpca.2024.006","url":null,"abstract":"The most common intraocular tumor in children is retinoblastoma. In developed countries, there has been an impressive rise in the survival rate and visual outcome of patients with retinoblastoma. This is clarified by developments in retinoblastoma treatment and early detection of tumors. The primary therapy remedy for intraocular retinoblastoma is now chemotherapy along with adjuvant consolidative treatment, instead of external beam radiation. Likewise, prophylactic chemotherapy is now allowed to treat potential micro metastases in enucleated eyes based on the identification of high-risk histopathological factors. Extra ocular retinoblastoma still has a poor future outcome; chances of survival have been reported to be between 50% and 70%. Retinoblastoma patients' overall survival is still struggling in developing countries, mostly because of delayed presentation and greater risk of extra ocular illness while compared to with the developed world, where intraocular disease contributes to majority of cases. To enhance the survival rate for those with retinoblastoma in developing countries, greater priority must be given to early detection of tumors. We provide a summary of the latest clinical management of retinoblastoma in this article.","PeriodicalId":14182,"journal":{"name":"International Journal of Pharmaceutical Chemistry and Analysis","volume":" 44","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140392022","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-03-15DOI: 10.18231/j.ijpca.2024.008
Jigar V. Patel, V. Patel, Pravinkumar M. Patel
Essential hypertension has been treated for over 30 years using both diuretics and beta-blockers. When it comes to treating heart failure, there are three different generations of beta-blockers that are now in use. Carvedilol is a blocker from the third generation. Nimodipine is a common L-type calcium channel blocker. The hypertension medication furosemide is a loop diuretic. This class of medications' low solubility in water has emerged as a serious obstacle in the pharmaceutical industry's pursuit of better treatments. A novel class of polymers called dendrimers has recently gained a lot of interest due to its impressive solubility-enhancing characteristics. Results from hemolysis studies and cytotoxicity tests using the novel nanostructure dendrimer shown here demonstrate superior performance of synthetic dendritic macromolecules compared to commercially available PAMAM dendrimer. Dendrimers are used to enhance the solubility of nimodipine, furosemide, and carvedilol up to 38.08µg/ml, 70.999µg/ml and 147.065µg/ml respectively. The enhancement of dendrimer-mediated solubility is primarily determined by factors such as dendrimer concentration and generation size. Drugs containing dendrimers may be studied using Fourier-transform infrared spectroscopy. Based on the results of this investigation, nanostructured dendrimer technology may help with hydrophobic medication dispersion.
使用利尿剂和β-受体阻滞剂治疗原发性高血压已有 30 多年的历史。在治疗心力衰竭方面，目前使用的β-受体阻滞剂有三代。卡维地洛（Carvedilol）是第三代受体阻滞剂。尼莫地平是一种常见的 L 型钙通道阻滞剂。高血压药物呋塞米是一种襻利尿剂。这类药物在水中的低溶解度已成为制药业寻求更好治疗方法的严重障碍。最近，一类名为树枝状聚合物的新型聚合物因其令人印象深刻的增溶特性而备受关注。本文展示的新型纳米结构树枝状聚合物的溶血研究和细胞毒性测试结果表明，与市售的 PAMAM 树枝状聚合物相比，合成树枝状大分子的性能更优越。树枝状聚合物用于提高尼莫地平、呋塞米和卡维地洛的溶解度，使其分别达到 38.08µg/ml、70.999µg/ml 和 147.065µg/ml。树枝状聚合物介导溶解度的提高主要取决于树枝状聚合物的浓度和生成大小等因素。含有树枝状聚合物的药物可使用傅立叶变换红外光谱进行研究。根据这项研究的结果，纳米结构树枝状聚合物技术可能有助于疏水性药物的分散。
{"title":"Nanostructured dendrimer improves the solubility of carvedilol, furosemide and nimodipine","authors":"Jigar V. Patel, V. Patel, Pravinkumar M. Patel","doi":"10.18231/j.ijpca.2024.008","DOIUrl":"https://doi.org/10.18231/j.ijpca.2024.008","url":null,"abstract":"Essential hypertension has been treated for over 30 years using both diuretics and beta-blockers. When it comes to treating heart failure, there are three different generations of beta-blockers that are now in use. Carvedilol is a blocker from the third generation. Nimodipine is a common L-type calcium channel blocker. The hypertension medication furosemide is a loop diuretic. This class of medications' low solubility in water has emerged as a serious obstacle in the pharmaceutical industry's pursuit of better treatments. A novel class of polymers called dendrimers has recently gained a lot of interest due to its impressive solubility-enhancing characteristics. Results from hemolysis studies and cytotoxicity tests using the novel nanostructure dendrimer shown here demonstrate superior performance of synthetic dendritic macromolecules compared to commercially available PAMAM dendrimer. Dendrimers are used to enhance the solubility of nimodipine, furosemide, and carvedilol up to 38.08µg/ml, 70.999µg/ml and 147.065µg/ml respectively. The enhancement of dendrimer-mediated solubility is primarily determined by factors such as dendrimer concentration and generation size. Drugs containing dendrimers may be studied using Fourier-transform infrared spectroscopy. Based on the results of this investigation, nanostructured dendrimer technology may help with hydrophobic medication dispersion.","PeriodicalId":14182,"journal":{"name":"International Journal of Pharmaceutical Chemistry and Analysis","volume":" 16","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140391320","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-03-15DOI: 10.18231/j.ijpca.2024.011
T. Anjali, P. Prasanna Kumar, N. Srinivas, K. Shivaji
Aceclofenac is a NSAID with anti-inflammatory, analgesic activity. The aim is to develop the Aceclofenac tablets with sida acuta powder that exhibit rapid disintegration, dissolution and showing maximum pharmacological activity in less time. This is desirable for improving patient compliance. The present study was to formulate and evaluate the fast-disintegrating tablets of Aceclofenac using Sida acuta powder by direct compression technique with varying concentrations. Each formulation was evaluated for pre and post evaluation tests such as Flow property, Bulk density, tapped density, Weight variation, Hardness, Friability, Wetting time, Disintegration time, Assay, in-vitro dissolution. Among the 06 formulations, F6 formulation Aceclofenac with 6%w/w of Sida acuta showed the in-vitro dissolution (99.75%) release of drug within 20 minutes and release of drug mechanism as first order kinetics. It was concluded that the fast-disintegrating tablets are prepared by Natural polymer Sida acuta acts as a disintegrant and showed excellent disintegration time,enhance the dissolution rate.
{"title":"Formulation and evaluation of aceclofenac fast disintegrating tablets using sida acuta powder","authors":"T. Anjali, P. Prasanna Kumar, N. Srinivas, K. Shivaji","doi":"10.18231/j.ijpca.2024.011","DOIUrl":"https://doi.org/10.18231/j.ijpca.2024.011","url":null,"abstract":"Aceclofenac is a NSAID with anti-inflammatory, analgesic activity. The aim is to develop the Aceclofenac tablets with sida acuta powder that exhibit rapid disintegration, dissolution and showing maximum pharmacological activity in less time. This is desirable for improving patient compliance. The present study was to formulate and evaluate the fast-disintegrating tablets of Aceclofenac using Sida acuta powder by direct compression technique with varying concentrations. Each formulation was evaluated for pre and post evaluation tests such as Flow property, Bulk density, tapped density, Weight variation, Hardness, Friability, Wetting time, Disintegration time, Assay, in-vitro dissolution. Among the 06 formulations, F6 formulation Aceclofenac with 6%w/w of Sida acuta showed the in-vitro dissolution (99.75%) release of drug within 20 minutes and release of drug mechanism as first order kinetics. It was concluded that the fast-disintegrating tablets are prepared by Natural polymer Sida acuta acts as a disintegrant and showed excellent disintegration time,enhance the dissolution rate.","PeriodicalId":14182,"journal":{"name":"International Journal of Pharmaceutical Chemistry and Analysis","volume":" 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140391348","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-03-15DOI: 10.18231/j.ijpca.2024.012
P. Prasanna Kumar, T. Anjali, Srinivas Nandyala, K. Sivaji
Diclofenac sodium is an agent shows Anti-Inflammatory, Anti-pyretic and Analgesic activity. The present work of the study is to design, formulate a tablet by using powder from Corn silk which disintegrate, dissolve rapidly, thereby gives rapid onset of action and investigate the fast-disintegrating property. The natural polymer chosen for the purpose of study is due to disintegrating property, non-toxicity, low cost, reliable, free availability, eco-friendly, potentially degradable and compatible. The formulation has been preparedCorn silkpowderwithvarious 05 different concentrations 2-10%W/W using direct compression method and evaluations are conducted. Each formulation has been Evaluated for various parameters of pre and post compression tablets namely Bulk density, tapped density, Angle of repose, Weight variation, Hardness, Friability, Wetting time, Disintegration time, In- vitro dissolution studies. The in vitro dissolution studies revealed that F5 with 10%w/w of Corn silk achieved a remarkable release of 99.98% of the drug within 25 minutes.The inclusion of corn silk in F5 significantly enhances the dissolution rate of diclofenac sodium compared with other formulations.
{"title":"Design, formulation and in-vitro evaluation of diclofenac sodium fast disintegrating tablets","authors":"P. Prasanna Kumar, T. Anjali, Srinivas Nandyala, K. Sivaji","doi":"10.18231/j.ijpca.2024.012","DOIUrl":"https://doi.org/10.18231/j.ijpca.2024.012","url":null,"abstract":"Diclofenac sodium is an agent shows Anti-Inflammatory, Anti-pyretic and Analgesic activity. The present work of the study is to design, formulate a tablet by using powder from Corn silk which disintegrate, dissolve rapidly, thereby gives rapid onset of action and investigate the fast-disintegrating property. The natural polymer chosen for the purpose of study is due to disintegrating property, non-toxicity, low cost, reliable, free availability, eco-friendly, potentially degradable and compatible. The formulation has been preparedCorn silkpowderwithvarious 05 different concentrations 2-10%W/W using direct compression method and evaluations are conducted. Each formulation has been Evaluated for various parameters of pre and post compression tablets namely Bulk density, tapped density, Angle of repose, Weight variation, Hardness, Friability, Wetting time, Disintegration time, In- vitro dissolution studies. The in vitro dissolution studies revealed that F5 with 10%w/w of Corn silk achieved a remarkable release of 99.98% of the drug within 25 minutes.The inclusion of corn silk in F5 significantly enhances the dissolution rate of diclofenac sodium compared with other formulations.","PeriodicalId":14182,"journal":{"name":"International Journal of Pharmaceutical Chemistry and Analysis","volume":" 8","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140391576","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
About 2 million deaths occur annually, and 4% of all deaths are caused by liver disease, which ranks as the 11 leading cause of death worldwide. This review includes the different kinds of liver disorders and their global prevalence. It focuses primarily on areas where significant new data is available, such as drug-induced liver injury, acute chronic liver disease, hepatocellular carcinoma, non-alcoholic fatty liver disease, alcoholic liver disease, and viral hepatitis. Most deaths are attributed to complications arising from hepatocellular carcinoma and cirrhosis. Obesity in Early life is an independent risk factor for cancer and cirrhosis. In the western world, alcohol is the primary cause of liver cirrhosis. It also covers some special considerations, such as hepatic conditions during COVID-19 and pregnancy, with a retrospective study. Additionally, we cover important data on sign symptoms, prevention, diagnosis with specialized techniques, and treatment with various drugs.
{"title":"Overview: Global burden of liver disease","authors":"Krushna Baviskar, Aniket Kshirsagar, Hemant Raut, M.R.N Shaikh","doi":"10.18231/j.ijpca.2024.001","DOIUrl":"https://doi.org/10.18231/j.ijpca.2024.001","url":null,"abstract":"About 2 million deaths occur annually, and 4% of all deaths are caused by liver disease, which ranks as the 11 leading cause of death worldwide. This review includes the different kinds of liver disorders and their global prevalence. It focuses primarily on areas where significant new data is available, such as drug-induced liver injury, acute chronic liver disease, hepatocellular carcinoma, non-alcoholic fatty liver disease, alcoholic liver disease, and viral hepatitis. Most deaths are attributed to complications arising from hepatocellular carcinoma and cirrhosis. Obesity in Early life is an independent risk factor for cancer and cirrhosis. In the western world, alcohol is the primary cause of liver cirrhosis. It also covers some special considerations, such as hepatic conditions during COVID-19 and pregnancy, with a retrospective study. Additionally, we cover important data on sign symptoms, prevention, diagnosis with specialized techniques, and treatment with various drugs.","PeriodicalId":14182,"journal":{"name":"International Journal of Pharmaceutical Chemistry and Analysis","volume":" 38","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140392028","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-03-15DOI: 10.18231/j.ijpca.2024.003
Rohit Doke, Ritik R Matade, Swarup Harne, Sakshi Kale, Yashodhan Ponde, Tejas S Naik, Ganesh Lamkhade
Psoriasis, characterized by immune-mediated inflammation triggered by dysfunctions in the immune system, manifests in various skin areas with elevated plaques presenting as common symptoms. Traditional psoriasis treatments often incorporate plant-based remedies, which, although safer, are predominantly hydrophobic, limiting their permeation and absorption into the skin. To address these challenges, researchers have turned to emulgels as drug delivery systems. Emulgels, combining the properties of both emulsions and gels, effectively solubilize hydrophobic drug molecules, enhancing their absorption through the skin. Emulgels shows several advantages including easy application and removal, emollient properties, non-greasiness, cosmetic appeal, and excellent penetration capabilities.This review emphasizes the significance of herbal drugs in psoriasis therapeutics and explores the utilization of emulgels as a delivery system for herbal extracts and constituents in psoriasis treatment. By highlighting the potential of emulgels in enhancing the delivery of herbal remedies for psoriasis management, this review offers insights into novel approaches to address the challenges associated with traditional psoriasis treatments.
{"title":"Therapeutic landscape of natural products and emulgel in psoriasis","authors":"Rohit Doke, Ritik R Matade, Swarup Harne, Sakshi Kale, Yashodhan Ponde, Tejas S Naik, Ganesh Lamkhade","doi":"10.18231/j.ijpca.2024.003","DOIUrl":"https://doi.org/10.18231/j.ijpca.2024.003","url":null,"abstract":"Psoriasis, characterized by immune-mediated inflammation triggered by dysfunctions in the immune system, manifests in various skin areas with elevated plaques presenting as common symptoms. Traditional psoriasis treatments often incorporate plant-based remedies, which, although safer, are predominantly hydrophobic, limiting their permeation and absorption into the skin. To address these challenges, researchers have turned to emulgels as drug delivery systems. Emulgels, combining the properties of both emulsions and gels, effectively solubilize hydrophobic drug molecules, enhancing their absorption through the skin. Emulgels shows several advantages including easy application and removal, emollient properties, non-greasiness, cosmetic appeal, and excellent penetration capabilities.This review emphasizes the significance of herbal drugs in psoriasis therapeutics and explores the utilization of emulgels as a delivery system for herbal extracts and constituents in psoriasis treatment. By highlighting the potential of emulgels in enhancing the delivery of herbal remedies for psoriasis management, this review offers insights into novel approaches to address the challenges associated with traditional psoriasis treatments.","PeriodicalId":14182,"journal":{"name":"International Journal of Pharmaceutical Chemistry and Analysis","volume":" 11","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140391527","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-12-15DOI: 10.18231/j.ijpca.2023.045
Bhavini K Gharia, B. Suhagia, Vineet Jain
In the present study we have reported the synthesis of some novel heterocyclic derivatives comprising imidazole and 1,3,4-thiadiazole containing cyclopropyl moiety. Imidazothiadiazoles are of interest because of their diverse biological activities and clinical applications. Primarily docking studies are carried out with reference structure Pdb code:2DKO. We have reported the new series of 5,6 diaryl substituted with imidazo[2,1- b], , thiadiazoles analogs to target caspase family cysteine proteases. The reaction was monitored by Thin-layer chromatography using suitable mobile phase. The Rf values were compared and determined the melting point of synthesized compounds. Further these derivatives were characterized and confirmed by IR, 1H-NMR, 13C-NMR, and Mass spectral (MS) studies. For anticancer activity, all the selected compounds submitted to National Cancer Institute (NCI) for in vitro anticancer assay were evaluated for their anticancer activity. Primary one dose anticancer assay was performed in full NCI 60 cell panel in accordance with the protocol of the NCI, USA. The compounds and showed good activity against all cancer cell lines. The synthesized drugs were monitored with Caspase 3 inhibitor kit.(CASP3C-1KT)using colorimeteric assay.
{"title":"Synthesis, crystal structure studies, characterization and study of novel heterocyclic thiadiazoles as caspase 3 inhibitors for anticancer activity","authors":"Bhavini K Gharia, B. Suhagia, Vineet Jain","doi":"10.18231/j.ijpca.2023.045","DOIUrl":"https://doi.org/10.18231/j.ijpca.2023.045","url":null,"abstract":"In the present study we have reported the synthesis of some novel heterocyclic derivatives comprising imidazole and 1,3,4-thiadiazole containing cyclopropyl moiety. Imidazothiadiazoles are of interest because of their diverse biological activities and clinical applications. Primarily docking studies are carried out with reference structure Pdb code:2DKO. We have reported the new series of 5,6 diaryl substituted with imidazo[2,1- b], , thiadiazoles analogs to target caspase family cysteine proteases. The reaction was monitored by Thin-layer chromatography using suitable mobile phase. The Rf values were compared and determined the melting point of synthesized compounds. Further these derivatives were characterized and confirmed by IR, 1H-NMR, 13C-NMR, and Mass spectral (MS) studies. For anticancer activity, all the selected compounds submitted to National Cancer Institute (NCI) for in vitro anticancer assay were evaluated for their anticancer activity. Primary one dose anticancer assay was performed in full NCI 60 cell panel in accordance with the protocol of the NCI, USA. The compounds and showed good activity against all cancer cell lines. The synthesized drugs were monitored with Caspase 3 inhibitor kit.(CASP3C-1KT)using colorimeteric assay.","PeriodicalId":14182,"journal":{"name":"International Journal of Pharmaceutical Chemistry and Analysis","volume":"24 5","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138997730","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-12-15DOI: 10.18231/j.ijpca.2023.047
Abm Mahfuz ul Alam, I. Mamun, Nilufar Nahar, M. Shoeb
This study emphasizes the pivotal role of Quality by Design (QbD) in the development of pharmaceutical methods, with a particular focus on risk assessment to ensure consistent quality. The research showcases the creation of a precise and practical HPLC method for Linagliptin Tablets, developed using QbD principles. This optimized method, designed through a systematic Design of Experiment approach, provides a robust and cost-effective solution for pharmaceutical analysis, promoting the consistent quality required within predefined specifications. The method employs C18 column (150 mm x 4.6 mm, 5μM) and employs isocratic elution with a mobile phase composed of Acetonitrile: Sodium Acetate Buffer with a pH of 4.5 in a ratio of 25:75. The flow rate was optimized at 1.0 mL/min, and peak detection was achieved using a UV detector set at 294 nm. The injection volume was standardized at 10 µL, and the Column Oven Temperature was maintained at 25°C. Rigorous validation following ICH Q 2 (R1) and USP <1225> guidelines ensure the method's reliability, with assessments of parameters such as limit of detection (LOD), limit of quantification (LOQ), accuracy, precision, and robustness. The method's exceptional sensitivity, selectivity, efficiency, precision, accuracy, and cost-effectiveness make it an optimal choice for pharmaceutical analysis of Linagliptin Tablets.This method is intended for further use in routine analysis for quality control in the pharmaceutical industry and has demonstrated the ability to distinguish marketed products, including comparability with the innovator product.
{"title":"A Quality by Design (QBD) approach for the development and validation of RP-HPLC method for the quantification of linagliptin tablets","authors":"Abm Mahfuz ul Alam, I. Mamun, Nilufar Nahar, M. Shoeb","doi":"10.18231/j.ijpca.2023.047","DOIUrl":"https://doi.org/10.18231/j.ijpca.2023.047","url":null,"abstract":"This study emphasizes the pivotal role of Quality by Design (QbD) in the development of pharmaceutical methods, with a particular focus on risk assessment to ensure consistent quality. The research showcases the creation of a precise and practical HPLC method for Linagliptin Tablets, developed using QbD principles. This optimized method, designed through a systematic Design of Experiment approach, provides a robust and cost-effective solution for pharmaceutical analysis, promoting the consistent quality required within predefined specifications. The method employs C18 column (150 mm x 4.6 mm, 5μM) and employs isocratic elution with a mobile phase composed of Acetonitrile: Sodium Acetate Buffer with a pH of 4.5 in a ratio of 25:75. The flow rate was optimized at 1.0 mL/min, and peak detection was achieved using a UV detector set at 294 nm. The injection volume was standardized at 10 µL, and the Column Oven Temperature was maintained at 25°C. Rigorous validation following ICH Q 2 (R1) and USP <1225> guidelines ensure the method's reliability, with assessments of parameters such as limit of detection (LOD), limit of quantification (LOQ), accuracy, precision, and robustness. The method's exceptional sensitivity, selectivity, efficiency, precision, accuracy, and cost-effectiveness make it an optimal choice for pharmaceutical analysis of Linagliptin Tablets.This method is intended for further use in routine analysis for quality control in the pharmaceutical industry and has demonstrated the ability to distinguish marketed products, including comparability with the innovator product.","PeriodicalId":14182,"journal":{"name":"International Journal of Pharmaceutical Chemistry and Analysis","volume":"33 4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138997862","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-12-15DOI: 10.18231/j.ijpca.2023.038
S. Tiware, Komal Khond Warghane, Priyanka Waghmare, Neha P. Rumale
Face wash is the products which is used to cleanse face without drying it out. It is also commonly known as “cleanser”. This product is found to be equally good for all skin type. A face wash is a mild cleanser that does the vital job of keeping skin clean, germ free, smooth and fresh and moisturizes the horny layer without any harshness to the skin. So that skin looks young and energetic. There are various types of herbal ingredients which can be used for manufacturing of face wash. This article is a review about various types ayurvedic or herbal ingredients which can be used for production of herbal face wash.
{"title":"A review on herbal face wash","authors":"S. Tiware, Komal Khond Warghane, Priyanka Waghmare, Neha P. Rumale","doi":"10.18231/j.ijpca.2023.038","DOIUrl":"https://doi.org/10.18231/j.ijpca.2023.038","url":null,"abstract":"Face wash is the products which is used to cleanse face without drying it out. It is also commonly known as “cleanser”. This product is found to be equally good for all skin type. A face wash is a mild cleanser that does the vital job of keeping skin clean, germ free, smooth and fresh and moisturizes the horny layer without any harshness to the skin. So that skin looks young and energetic. There are various types of herbal ingredients which can be used for manufacturing of face wash. This article is a review about various types ayurvedic or herbal ingredients which can be used for production of herbal face wash.","PeriodicalId":14182,"journal":{"name":"International Journal of Pharmaceutical Chemistry and Analysis","volume":"4 32","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139001025","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-12-15DOI: 10.18231/j.ijpca.2023.040
Vikas R. Patil, G. Vadnere, K. D. Baviskar, Vinay V. Sarode, Jayesh T. Nimbalkar
A selective COX-2 inhibitor Rofecoxib it is a non-steroidal anti-inflammatory (NSAIDs) medicines work by inhibiting the COX enzyme, which is a mediator of inflammation. Rofecoxib is used to treat rheumatoid arthritis, osteoarthritis, and primary dysmenorrhea. The main objective of this study is to examine Rofecoxib in pharmaceutical and biological formulations both qualitative and quantitative. In this review paper, we have outlined the approaches based on UV/Vis spectroscopy, High-performance liquid chromatography (HPLC), High-performance thin layer chromatography (HPTLC) and Liquid chromatography-mass spectrometry (LC-MS) for estimating rofecoxib. We have also discussed the bioanalytical methods used to analyse RFX. In conclusion, this review paper will aid researchers in developing new techniques for drug estimation in biological fluids and pharmaceutical dosage forms.
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