Pub Date : 2024-07-15DOI: 10.18231/j.ijpca.2024.027
X. Fatima Grace, K. Himana Begam, A. Janani, M. Jayaram
The formulation and evaluation of a natural lip balm with beetroot juice as the main ingredient are the main subjects of this study. Due to its natural pigments and moisturising qualities, beetroot known for its rich colour and possible health benefits is a promising ingredient in cosmetics. The research begins with the development of a formulation incorporating beetroot juice alongside other natural ingredients to create a lip balm product.Subsequently, the physical, chemical, and sensory aspects of the lip balm formulation are evaluated. The overall quality and consumer attractiveness of the product are assessed by analysing various parameters, including colour, pH, texture, fragrance, and moisturising efficacy. Furthermore, stability checks are carried out to ensure the durability and shelf-life of the lip balm under different storage conditions.The findings of this study aim to contribute to the growing demand for natural and sustainable cosmetics while providing insights into the potential benefits of utilising beetroot juice in lip care products. Ultimately, the research seeks to offer a viable alternative to conventional lip balms, promoting both health-conscious and eco-friendly beauty solutions.
{"title":"Formulation and evaluation of natural lip balm","authors":"X. Fatima Grace, K. Himana Begam, A. Janani, M. Jayaram","doi":"10.18231/j.ijpca.2024.027","DOIUrl":"https://doi.org/10.18231/j.ijpca.2024.027","url":null,"abstract":"The formulation and evaluation of a natural lip balm with beetroot juice as the main ingredient are the main subjects of this study. Due to its natural pigments and moisturising qualities, beetroot known for its rich colour and possible health benefits is a promising ingredient in cosmetics. The research begins with the development of a formulation incorporating beetroot juice alongside other natural ingredients to create a lip balm product.Subsequently, the physical, chemical, and sensory aspects of the lip balm formulation are evaluated. The overall quality and consumer attractiveness of the product are assessed by analysing various parameters, including colour, pH, texture, fragrance, and moisturising efficacy. Furthermore, stability checks are carried out to ensure the durability and shelf-life of the lip balm under different storage conditions.The findings of this study aim to contribute to the growing demand for natural and sustainable cosmetics while providing insights into the potential benefits of utilising beetroot juice in lip care products. Ultimately, the research seeks to offer a viable alternative to conventional lip balms, promoting both health-conscious and eco-friendly beauty solutions.","PeriodicalId":14182,"journal":{"name":"International Journal of Pharmaceutical Chemistry and Analysis","volume":" 14","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141833047","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-07-15DOI: 10.18231/j.ijpca.2024.019
Rimjhim Arora, Kamal Singh Rathore, S. S. Saurabh
The treatment of behavioral and psychological symptoms of dementia (BPSD) in Alzheimer's disease (AD) is crucial for individuals with the condition. Cholinesterase inhibitors (CIs) and memantine, used for cognitive symptoms, may have some effect on BPSD, but additional drugs may be needed as BPSD worsens. Selective serotonin reuptake inhibitors (SSRIs) like fluoxetine, sertraline, and others are effective antidepressants for comorbid depression in AD. Limited evidence supports their use for treating depression, agitation, and psychosis in AD, but recent trials showed no benefit and increased risks. Non-pharmacological interventions such as psycho social approaches and alternative therapies are important. A comprehensive approach combining medication and non-pharmacological interventions, along with close monitoring, is essential for managing BPSD and improving quality of life for individuals with AD and their caregivers.
治疗阿尔茨海默病（AD）痴呆的行为和心理症状（BPSD）对患者至关重要。用于治疗认知症状的胆碱酯酶抑制剂（CIs）和美金刚，可能会对行为和心理症状产生一些影响，但随着行为和心理症状的恶化，可能还需要额外的药物。选择性血清素再摄取抑制剂（SSRIs），如氟西汀、舍曲林等，是治疗AD合并抑郁症的有效抗抑郁药物。有限的证据支持将这些药物用于治疗注意力缺失症患者的抑郁、躁动和精神病，但最近的试验表明这些药物无益且风险增加。非药物干预措施也很重要，如社会心理疗法和替代疗法。结合药物和非药物干预措施的综合方法以及密切监测，对于控制 BPSD 和改善 AD 患者及其护理者的生活质量至关重要。
{"title":"Review on Alzheimer’s disease","authors":"Rimjhim Arora, Kamal Singh Rathore, S. S. Saurabh","doi":"10.18231/j.ijpca.2024.019","DOIUrl":"https://doi.org/10.18231/j.ijpca.2024.019","url":null,"abstract":"The treatment of behavioral and psychological symptoms of dementia (BPSD) in Alzheimer's disease (AD) is crucial for individuals with the condition. Cholinesterase inhibitors (CIs) and memantine, used for cognitive symptoms, may have some effect on BPSD, but additional drugs may be needed as BPSD worsens. Selective serotonin reuptake inhibitors (SSRIs) like fluoxetine, sertraline, and others are effective antidepressants for comorbid depression in AD. Limited evidence supports their use for treating depression, agitation, and psychosis in AD, but recent trials showed no benefit and increased risks. Non-pharmacological interventions such as psycho social approaches and alternative therapies are important. A comprehensive approach combining medication and non-pharmacological interventions, along with close monitoring, is essential for managing BPSD and improving quality of life for individuals with AD and their caregivers.","PeriodicalId":14182,"journal":{"name":"International Journal of Pharmaceutical Chemistry and Analysis","volume":" 17","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141832969","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-07-15DOI: 10.18231/j.ijpca.2024.018
S. Chaudhry, Abhijit Tailokya, Gopal Wawde, Yogesh Bhide, Kavita Inamdar
Alogliptin was initially approved to treat T2DM in Japan in 2010 and then approved by FDA and by EMA in 2013. Alogliptin, a highly potent and selective, noncovalent inhibitor of DPP-4. Inhibition of DPP-4 activity, alogliptin slows the inactivation of incretin hormones, glucagon-like peptide-1 (GLP-1). In terms of drug safety alogliptin is generally well-tolerated, with a low risk of hypoglycemia, weight gain, acute pancreatitis, and hepatotoxicity. Alogliptin has been effectively combined with Metformin or Pioglitazone to provide better glycaemic control. The drug can be used in mild hepatic or renal impairment with appropriate dosage adjustment. Treatment with alogliptin has shown less weight gain compared with sulfonylureas. Alogliptin and FDC of Alogliptin + Metformin approved and available in India with brand name Aloja & Aloja M/Forte, with well documented safety and efficacy through phase IV study conducted in India.
{"title":"Steps in discovery of alogliptin","authors":"S. Chaudhry, Abhijit Tailokya, Gopal Wawde, Yogesh Bhide, Kavita Inamdar","doi":"10.18231/j.ijpca.2024.018","DOIUrl":"https://doi.org/10.18231/j.ijpca.2024.018","url":null,"abstract":"Alogliptin was initially approved to treat T2DM in Japan in 2010 and then approved by FDA and by EMA in 2013. Alogliptin, a highly potent and selective, noncovalent inhibitor of DPP-4. Inhibition of DPP-4 activity, alogliptin slows the inactivation of incretin hormones, glucagon-like peptide-1 (GLP-1). In terms of drug safety alogliptin is generally well-tolerated, with a low risk of hypoglycemia, weight gain, acute pancreatitis, and hepatotoxicity. Alogliptin has been effectively combined with Metformin or Pioglitazone to provide better glycaemic control. The drug can be used in mild hepatic or renal impairment with appropriate dosage adjustment. Treatment with alogliptin has shown less weight gain compared with sulfonylureas. Alogliptin and FDC of Alogliptin + Metformin approved and available in India with brand name Aloja & Aloja M/Forte, with well documented safety and efficacy through phase IV study conducted in India.","PeriodicalId":14182,"journal":{"name":"International Journal of Pharmaceutical Chemistry and Analysis","volume":" 16","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141833033","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-07-15DOI: 10.18231/j.ijpca.2024.023
S.M. Attar, S. Ghurghure, Sumit
Oral route is considered as one of the most convenient route for administration of various pharmaceutical dosage form like tablet, capsule, syrup, suspension and emulsion. Fast Dissolving Drug Delivery systems have developed various fast disintegrating preparations like Oral disintegrating film, ODF. Oral disintegrating film is the solid oral drug delivery system, in which water soluble polymer involve to disintegrate film into mouth fastly. Oral disintegrating film is superior as compare to orally disintegrating tablet as the cost of production is low. The present research was undertaken to develop oral disintegrating film of tteneligliptin hydrobromide hydrate to have rapid onset of action. of tteneligliptin hydrobromide hydrate which is an anti-diabetic. The mechanism action of Teneligliptin is to increase incretin levels (GLP-1 and GIP), which inhibit glucagon release, which in turn increases insulin secretion, decreases gastric emptying, and decreases blood glucose levels.The concept of formulating fast disintegrating film Teneligliptin containing offers a suitable and practical approach in serving desired objective of faster disintegration and dissolution characteristics with increased bioavailability. ODF of Teneligliptin were prepared by solvent casting method and evaluated physicochemical parameters like thickness, weight variation, moisture content, folding endurance, drug content, etc. All the formulations of Teneligliptin ODF displayed optimum folding endurance, which indicates the formulation prepared can withstand handling and transportation. From the results obtained, it was concluded that the formulation of oral disintegrating film has better physical chemical properties with good disintegration property.
{"title":"Teneligliptin hydrobromide hydrate mouth dissolving strip: Formulation and evaluation","authors":"S.M. Attar, S. Ghurghure, Sumit","doi":"10.18231/j.ijpca.2024.023","DOIUrl":"https://doi.org/10.18231/j.ijpca.2024.023","url":null,"abstract":"Oral route is considered as one of the most convenient route for administration of various pharmaceutical dosage form like tablet, capsule, syrup, suspension and emulsion. Fast Dissolving Drug Delivery systems have developed various fast disintegrating preparations like Oral disintegrating film, ODF. Oral disintegrating film is the solid oral drug delivery system, in which water soluble polymer involve to disintegrate film into mouth fastly. Oral disintegrating film is superior as compare to orally disintegrating tablet as the cost of production is low. The present research was undertaken to develop oral disintegrating film of tteneligliptin hydrobromide hydrate to have rapid onset of action. of tteneligliptin hydrobromide hydrate which is an anti-diabetic. The mechanism action of Teneligliptin is to increase incretin levels (GLP-1 and GIP), which inhibit glucagon release, which in turn increases insulin secretion, decreases gastric emptying, and decreases blood glucose levels.The concept of formulating fast disintegrating film Teneligliptin containing offers a suitable and practical approach in serving desired objective of faster disintegration and dissolution characteristics with increased bioavailability. ODF of Teneligliptin were prepared by solvent casting method and evaluated physicochemical parameters like thickness, weight variation, moisture content, folding endurance, drug content, etc. All the formulations of Teneligliptin ODF displayed optimum folding endurance, which indicates the formulation prepared can withstand handling and transportation. From the results obtained, it was concluded that the formulation of oral disintegrating film has better physical chemical properties with good disintegration property.","PeriodicalId":14182,"journal":{"name":"International Journal of Pharmaceutical Chemistry and Analysis","volume":" 81","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141833757","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-07-15DOI: 10.18231/j.ijpca.2024.015
Naseef PP, Femina K P, Navaneeth Krishnan, Shifana, Shijiya Sherin KP, Vighnesh S
Antiperspirants are typically applied to the under arms, to prevent or reduce perspiration and odour, providing comfort and confidence to individuals. Antiperspirants are one of the most commonly used cosmetics with millions of people applying them to their axillae regularly. Aluminium salts are commonly used as antiperspirants which increase alzhimer’s disease, breast and prostate cancer and, contact dermatitis. As a result plant extract with antibacterial properties are useful. Herbal cosmetics products are believed to have effectiveness and inherent acceptability due to their wide spread use in everyday life while avoiding negative effects associated with synthetic products. The natural plant extracts like helps to avoid the adverse effects caused by chemicals and offer a promising avenue for developing effective and safe antiperspirant formulations.
{"title":"Design and development of antiperspirant formulation from natural extract: An overview","authors":"Naseef PP, Femina K P, Navaneeth Krishnan, Shifana, Shijiya Sherin KP, Vighnesh S","doi":"10.18231/j.ijpca.2024.015","DOIUrl":"https://doi.org/10.18231/j.ijpca.2024.015","url":null,"abstract":"Antiperspirants are typically applied to the under arms, to prevent or reduce perspiration and odour, providing comfort and confidence to individuals. Antiperspirants are one of the most commonly used cosmetics with millions of people applying them to their axillae regularly. Aluminium salts are commonly used as antiperspirants which increase alzhimer’s disease, breast and prostate cancer and, contact dermatitis. As a result plant extract with antibacterial properties are useful. Herbal cosmetics products are believed to have effectiveness and inherent acceptability due to their wide spread use in everyday life while avoiding negative effects associated with synthetic products. The natural plant extracts like helps to avoid the adverse effects caused by chemicals and offer a promising avenue for developing effective and safe antiperspirant formulations.","PeriodicalId":14182,"journal":{"name":"International Journal of Pharmaceutical Chemistry and Analysis","volume":" 5","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141833005","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-07-15DOI: 10.18231/j.ijpca.2024.020
Alemu Tadesse Feroche, Frehiwot Beyene Woselassie
Macrocyclic kinase inhibitors have high binding affinity and selectivity towards a variety of kinases including mammalian target of rapamycin complex 1/2, janus kinases/ Fms like tyrosine kinase, cyclin-dependent kinases and anaplastic lymphoma kinase1. Recently, few macrocyclic kinase inhibitors have entered clinical trial for treatment different types of cancers including leukemia, non-small cell lung cancer, myelofibrosis, breast cancer, glioblastoma and lymphoma. Of them, ridaforomilus has completed Phase III clinical trial and is waiting to be approved for treatment of breast cancer and advanced leukemia. Pacritinib is also currently being tested in phase III clinical trial for treatment of myelofibrosis and, loratinib is being evaluated for advanced ALK gene positive nonsmall cell lung carcinoma. The broad-spectrum cyclin-dependent kinases inhibitor, TGO2, has also entered phase II clinical trial for treatment of glioblastoma and advanced leukemia.
大环激酶抑制剂对多种激酶具有高结合亲和力和选择性，这些激酶包括哺乳动物雷帕霉素靶复合物 1/2、janus 激酶/Fms 类酪氨酸激酶、细胞周期蛋白依赖性激酶和无性淋巴瘤激酶1。最近，一些大环激酶抑制剂已进入临床试验阶段，用于治疗不同类型的癌症，包括白血病、非小细胞肺癌、骨髓纤维化、乳腺癌、胶质母细胞瘤和淋巴瘤。其中，ridaforomilus 已完成 III 期临床试验，正在等待批准用于治疗乳腺癌和晚期白血病。帕克替尼（Pacritinib）目前也正在进行治疗骨髓纤维化的III期临床试验，而罗拉替尼（loratinib）则正在进行治疗晚期ALK基因阳性非小细胞肺癌的评估。广谱细胞周期蛋白依赖性激酶抑制剂 TGO2 也已进入治疗胶质母细胞瘤和晚期白血病的 II 期临床试验。
{"title":"A review on macrocyclic kinase inhibitors in clinical trials","authors":"Alemu Tadesse Feroche, Frehiwot Beyene Woselassie","doi":"10.18231/j.ijpca.2024.020","DOIUrl":"https://doi.org/10.18231/j.ijpca.2024.020","url":null,"abstract":"Macrocyclic kinase inhibitors have high binding affinity and selectivity towards a variety of kinases including mammalian target of rapamycin complex 1/2, janus kinases/ Fms like tyrosine kinase, cyclin-dependent kinases and anaplastic lymphoma kinase1. Recently, few macrocyclic kinase inhibitors have entered clinical trial for treatment different types of cancers including leukemia, non-small cell lung cancer, myelofibrosis, breast cancer, glioblastoma and lymphoma. Of them, ridaforomilus has completed Phase III clinical trial and is waiting to be approved for treatment of breast cancer and advanced leukemia. Pacritinib is also currently being tested in phase III clinical trial for treatment of myelofibrosis and, loratinib is being evaluated for advanced ALK gene positive nonsmall cell lung carcinoma. The broad-spectrum cyclin-dependent kinases inhibitor, TGO2, has also entered phase II clinical trial for treatment of glioblastoma and advanced leukemia.","PeriodicalId":14182,"journal":{"name":"International Journal of Pharmaceutical Chemistry and Analysis","volume":" 4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141832977","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The purpose of this study is to establish Zero-order UV-Spectrophotometric - absorbance and Zero Order- Area under curve (AUC) methods for estimation of Fenticonazole Nitrate in bulk and vaginal capsules. Fenticonazole Nitrate is an antifungal drug and it is completely insoluble in water. Methanol was used as solvent for solubilization of Fenticonazole Nitrate. Maximum absorption for Fenticonazole Nitrate was found to be at wavelength 253 nm when dissolved in Methanol. The methods are based upon measurement of absorbance at 253nm and integration of area under curve for analysis of Fenticonazole Nitrate in the wavelength range of 242-262 nm. The drug followed linearity in the concentration range of 5 - 30µg/mL with correlation coefficient value r> 0.99 for both methods. The proposed methods were validated for accuracy (% recovery), precision, repeatability and ruggedness, as per ICH guidelines. The proposed methods were applied for qualitative and quantitative estimation of Fenticonazole Nitrate in vaginal capsules and results were found in good agreement with the label claimed. Developed methods can be used for routine analysis of Fenticonazole Nitrate in bulk and Vaginal Capsules.
{"title":"Quantitative estimation of fenticonazole nitrate by zero-order derivative area under curve spectrophotometric methods in bulk and in-capsule dosage form","authors":"Ashish Gorle, Pritam Jain, Pankaj Nerkar, Nitin Haswani, Saurabh Chordiya, Saipudeen H. Kommakayam","doi":"10.18231/j.ijpca.2024.025","DOIUrl":"https://doi.org/10.18231/j.ijpca.2024.025","url":null,"abstract":"The purpose of this study is to establish Zero-order UV-Spectrophotometric - absorbance and Zero Order- Area under curve (AUC) methods for estimation of Fenticonazole Nitrate in bulk and vaginal capsules. Fenticonazole Nitrate is an antifungal drug and it is completely insoluble in water. Methanol was used as solvent for solubilization of Fenticonazole Nitrate. Maximum absorption for Fenticonazole Nitrate was found to be at wavelength 253 nm when dissolved in Methanol. The methods are based upon measurement of absorbance at 253nm and integration of area under curve for analysis of Fenticonazole Nitrate in the wavelength range of 242-262 nm. The drug followed linearity in the concentration range of 5 - 30µg/mL with correlation coefficient value r> 0.99 for both methods. The proposed methods were validated for accuracy (% recovery), precision, repeatability and ruggedness, as per ICH guidelines. The proposed methods were applied for qualitative and quantitative estimation of Fenticonazole Nitrate in vaginal capsules and results were found in good agreement with the label claimed. Developed methods can be used for routine analysis of Fenticonazole Nitrate in bulk and Vaginal Capsules.","PeriodicalId":14182,"journal":{"name":"International Journal of Pharmaceutical Chemistry and Analysis","volume":" 21","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141833030","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-07-15DOI: 10.18231/j.ijpca.2024.024
SK Umeraazmi, B. Krishna Reddy, K. Raja Sekhar Reddy, R. Ramesh, S. Jayasree, S. Sandeep, B. Thangabalan
Chalcone is an α,β- unsaturated ketone and central core for a variety of important biological compounds extracted from natural products and the experiment is conducted by performing identification tests to identify the chemical components in the compounds such as and are the main components used in this procedure. The synthesized jelly is developed and validated by ramipril and its linearity is found to be 10-50 µg/ml, precision % RSD of in intraday 35.7142 and in inter day 35.7277, Accuracy and recovery studies 80 %, 100%,120% are found to be 82,95,103,. Specificity % RSD is 29.43, Robustness wavelengths are taken as 210 nm, 211nm,212 nm found to be 3.345,26.182,21.038, LOD – 0.8µg/ml, LOQ - 2.5 µg/ml. The amount present in chalcone jelly in given sample of ramipril was 81µg/ml.
{"title":"Determination of the synthesised jelly by UV method development and validation of ramipril","authors":"SK Umeraazmi, B. Krishna Reddy, K. Raja Sekhar Reddy, R. Ramesh, S. Jayasree, S. Sandeep, B. Thangabalan","doi":"10.18231/j.ijpca.2024.024","DOIUrl":"https://doi.org/10.18231/j.ijpca.2024.024","url":null,"abstract":"Chalcone is an α,β- unsaturated ketone and central core for a variety of important biological compounds extracted from natural products and the experiment is conducted by performing identification tests to identify the chemical components in the compounds such as and are the main components used in this procedure. The synthesized jelly is developed and validated by ramipril and its linearity is found to be 10-50 µg/ml, precision % RSD of in intraday 35.7142 and in inter day 35.7277, Accuracy and recovery studies 80 %, 100%,120% are found to be 82,95,103,. Specificity % RSD is 29.43, Robustness wavelengths are taken as 210 nm, 211nm,212 nm found to be 3.345,26.182,21.038, LOD – 0.8µg/ml, LOQ - 2.5 µg/ml. The amount present in chalcone jelly in given sample of ramipril was 81µg/ml.","PeriodicalId":14182,"journal":{"name":"International Journal of Pharmaceutical Chemistry and Analysis","volume":" 17","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141833148","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-07-15DOI: 10.18231/j.ijpca.2024.026
Anurag Garg, Ravi Singhal, Shyamli Varshney
Regular supply of pure oxygen is the need of the hour to be prepared for the fresh waves of COVID-19. The cost of such oxygen supplies should be economical to reach out to the masses & avoid unwelcome burden on the national economy. A requirement has always been felt to identify an alternate source of oxygen generation with readily available raw materials which can ensure its cost effectiveness and last mile oxygen availability through independent generation capabilities.Chemical generation of oxygen has been the go-to technology for portable oxygen generation. However, the cost of production and controlling the reaction has generally been uneconomical for commercial applications. The authors undertook a task to build up a prototype of chemical oxygen generator which did not require compressed gas. It on the principle of dissociation of Sodium per carbonate (SPC) into sodium carbonate and hydrogen peroxide. Hydrogen peroxide so produced interacts with catalyst MnO which further decomposes to produce oxygen. A cast iron tank with a reaction chamber at the bottom is fabricated where upper tank consists of water and space for storing gases. The flow of the water is regulated to control the speed of the reaction.The chemical mixture of sodium percarbonate and manganese dioxide is tightly packed in a cloth bag.Oxygen release valve is kept at the top of the tank which is connected via a pipe to the standard to check the quantity of oxygen as well as the oxygen mask for the patient.This equipment, has a to be the in the fight against COVID especially in remote and difficult to access areas as well as areas without electricity.
{"title":"Getting prepared for the fresh COVID19 wave:","authors":"Anurag Garg, Ravi Singhal, Shyamli Varshney","doi":"10.18231/j.ijpca.2024.026","DOIUrl":"https://doi.org/10.18231/j.ijpca.2024.026","url":null,"abstract":"Regular supply of pure oxygen is the need of the hour to be prepared for the fresh waves of COVID-19. The cost of such oxygen supplies should be economical to reach out to the masses & avoid unwelcome burden on the national economy. A requirement has always been felt to identify an alternate source of oxygen generation with readily available raw materials which can ensure its cost effectiveness and last mile oxygen availability through independent generation capabilities.Chemical generation of oxygen has been the go-to technology for portable oxygen generation. However, the cost of production and controlling the reaction has generally been uneconomical for commercial applications. The authors undertook a task to build up a prototype of chemical oxygen generator which did not require compressed gas. It on the principle of dissociation of Sodium per carbonate (SPC) into sodium carbonate and hydrogen peroxide. Hydrogen peroxide so produced interacts with catalyst MnO which further decomposes to produce oxygen. A cast iron tank with a reaction chamber at the bottom is fabricated where upper tank consists of water and space for storing gases. The flow of the water is regulated to control the speed of the reaction.The chemical mixture of sodium percarbonate and manganese dioxide is tightly packed in a cloth bag.Oxygen release valve is kept at the top of the tank which is connected via a pipe to the standard to check the quantity of oxygen as well as the oxygen mask for the patient.This equipment, has a to be the in the fight against COVID especially in remote and difficult to access areas as well as areas without electricity.","PeriodicalId":14182,"journal":{"name":"International Journal of Pharmaceutical Chemistry and Analysis","volume":" 24","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141832690","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-07-15DOI: 10.18231/j.ijpca.2024.022
Kavita Shukla Pandey, Vinay Gajanan Polpelliwar, T. M. Shirbhate, Zohra Firdous, Pravin Krishnarao Gaidhane, M. Gaidhane
Herbal liquid formulations are the preparation for oral health related issues like toothache, swelling, redness, bacterial or fungal infection in mouth, tooth decay, bleeding gums, weakened gums, etc. Such preparation also improves gums strength, removing bad breath and give fresh feel during good start of the day. Dentists generally use such preparations as antimicrobials before or after oral surgery to sanitize the surface of affected gums and teeth to avoid further contamination. Herbs like Tulsi, Clove, Mint, Ginger etc., are generally used either alone or in combination in herbal mouth-wash preparations which also render antibacterial activities. The other herbs like Eucalyptus and Liquorices have been reported to possess antibacterial, anti-oxidant, aromatic, anti- inflammatory and sweetening properties. In the present work, the research continues with formulation and evaluation of a herbal mouth rinse by using a combination of selected herbal extracts of Tulsi, Bael, Eucalyptus leaves and Liquorices rhizome for their antimicrobial activity against S. aureus using agar well diffusion plate technique. It was found that the formulated herbal mouth rinse or preparations gave satisfactory results in controlling the microorganism. Different physicochemical tests of prepared preparations were performed to figure out their pH, phase separation, homogeneity and scent.,
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