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Genotoxic Effects of Spirotetramat on Allium Cepa L. 螺旋体对葱的遗传毒性研究。
Pub Date : 2021-07-01 DOI: 10.7176/JSTR/7-06-06
M. Gultekin, C. Aki
In this research the genotoxic effects of spirotetramat have been determined by the meaning of mitotic index (MI) and chromosomal abnormality in Allium cepa L. root tip meristematic cells. For this purpose the Allium test was carried out exposing roots to spirotetramat for 24 and 48 hours at the concentrations of 1 mL/L, 2 mL/L, 4 mL/L. After the spirotetramat applications, root tips have been harvested and standard mitotic test procedures have been realized. The mitotic index was calculated as the number of dividing cells per number of 1000 1500 observed cells and the chromosomal aberrations also were scored for each group. Our results have showed that the mitotic index significantly decreased with the increase of doses and exposure times when compare to their controls. According to our results, MI value has been decreased as 56% and 65% in 4 mL/L spirotetramat application after 24 and 48 hours respectively. As a result of our research, it was understood that the chromosomal aberration frequency increased in all application groups when we compare with the control group. According to chromosomal aberration frequency results, when we compare with control group chromosome aberration frequency increased approximately seven fold in 4 mL/L spirotetramat applications after 24 and 48 hours respectively. Our results showed that spirotetramat induced significant increases of chromosomal aberrations such as table and pole shifting, chromosomal bridge. In addition that mitotic index (MI) decreased significantly with increasing of spirotetramat doses and the exposure time as compared to their controls. Keywords: Allium cepa, spirotetramat, genotoxicity, mitotic index. DOI: 10.7176/JSTR/7-06-03
本研究通过对洋葱根尖分生组织细胞有丝分裂指数(MI)和染色体异常的意义来确定螺虫菌的遗传毒性作用。为此,在1 mL/L、2 mL/L、4 mL/L的浓度下,将葱根暴露在螺虫菌中24和48小时。施用螺虫剂后,收获根尖,并实现标准的有丝分裂试验程序。有丝分裂指数计算为每1000个观察细胞中分裂的细胞数,并对每组的染色体畸变进行评分。我们的研究结果表明,与对照组相比,有丝分裂指数随着剂量和暴露时间的增加而显著降低。根据我们的研究结果,施用4ml /L螺虫酯24小时和48小时后MI值分别下降56%和65%。我们的研究结果表明,与对照组相比,所有应用组的染色体畸变频率都有所增加。根据染色体畸变频率的结果,当我们与对照组相比,4 mL/L螺虫剂分别在24和48小时后染色体畸变频率增加了约7倍。我们的研究结果表明,螺虫病导致染色体畸变显著增加,如表移和极移,染色体桥。此外,与对照组相比,有丝分裂指数(MI)随螺虫曲霉剂量和暴露时间的增加而显著降低。关键词:葱,螺旋体,遗传毒性,有丝分裂指数。DOI: 10.7176 / JSTR / 7-06-03
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引用次数: 0
Rural and Central District Primary School Students Body Mass Index and Milk Consumption Habits 农村和中心区小学生体质指数与牛奶消费习惯
Pub Date : 2021-07-01 DOI: 10.7176/jstr/7-06-02
Serap Goncu
This study was to planned investigate the milk consumption and body mass index values in rural and central district primary school students. In this context, a questionnaire was applied to 152 children from 59 families, 25 of whom were in the center and 34 living in the countryside, during home visits. In addition, during the survey, the height and weight of the participants were determined and the body mass index values were calculated. The drinking habits of rural and central district students participating in the study were 35% in the evenings for rural girls and 48% for boys (p=0.211); the central region was found to be 55% in girls and 59% in boys (p=0.282). While 20.62% of the children in the families participating in the survey liked hot milk, 23.5% liked cold milk, 29.4% stated that they liked to drink milk with fruit. Although 90% of the respondents in this study say that they like milk, it is understood that there is irregular milk consumption.
本研究旨在调查农村及中心区小学生的牛奶消费量与体质指数。在此背景下,在家访期间对来自59个家庭的152名儿童进行了问卷调查,其中25名在中心,34名生活在农村。此外,在调查过程中,确定了参与者的身高和体重,并计算了体重指数值。参加研究的农村和中心区学生夜间饮酒习惯,农村女孩为35%,男孩为48% (p=0.211);中央区女生占55%,男生占59% (p=0.282)。在参与调查的家庭中,20.62%的孩子喜欢热牛奶,23.5%的孩子喜欢冷牛奶,29.4%的孩子表示喜欢喝水果牛奶。虽然本研究中90%的受访者表示喜欢牛奶,但据了解,他们的牛奶消费是不规律的。
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引用次数: 0
The Evaluation of Wnt Pathway Proteins (Wnt-1/Β-Catenin/ E-Cadherin) in Bone Marrow Biopsies in Essential Thrombocythemia and Polycythemia Vera 原发性血小板增多症和真性红细胞增多症患者骨髓活检中Wnt通路蛋白(Wnt-1/Β-Catenin/ E-Cadherin)的评价
Pub Date : 2021-07-01 DOI: 10.7176/jstr/7-06-04
H. Kucuk, U. Cobanoglu, M. Sonmez
The aim of the study is to investigate the expressions of Wnt signal pathway proteins (Wnt 1/Β Catenin/E Cadherin) in polycythemia vera and essential thrombocythemia. In addition to 25 Polycythemia vera and 25 Essential thrombocytosis cases who received bone marrow biopsies with the diagnoses of Polycythemia vera and Essential thrombocytosis, 25 normocellular bone marrow biopsies were included as the control group. In cells belonging to erythroid, myeloid and megakaryocytic series in the bone marrow biopsies of the cases, Wnt 1, β catenin and E cadherin expressions were examined by the immunohistochemical method. For each series, staining up to 10% was accepted as negative, and 10% and higher staining was accepted as positive. In the Essential thrombocytosis cases, there was a significant increase in the Wnt 1 expression in the megakaryocytic series and E cadherin expression in the erythroid series (p<0.05). When the cases were assessed within themselves based on the three series, an increase in E cadherin and E cadherin expression in the erythroid series in the Polycythemia vera cases and Wnt 1 expression in the megakaryocytic series in the Essential thrombocytosis cases was observed (p<0.05). β catenin expression was not encountered in the cases. Consequently, it was considered that Wnt 1 may be associated with megakaryocytopoiesis in ET cases, and E cadherin may be associated with erythropoiesis in ET cases. However, it will be beneficial to repeat the study on broader myeloproliferative neoplasm series and assess other factors in the Wnt pathway. Keywords: Essential Thrombocytosis, Polycythemia Vera, Wnt 1, β catenin, E cadherin DOI: 10.7176/JSTR/7-06-04
本研究旨在探讨Wnt信号通路蛋白(Wnt 1/Β Catenin/E Cadherin)在真性红细胞增多症和原发性血小板增多症中的表达。除25例真性红细胞增多症和25例原发性血小板增多症患者行骨髓活检诊断为真性红细胞增多症和原发性血小板增多症外,25例正常细胞骨髓活检为对照组。采用免疫组化方法检测患者骨髓活检属红系、髓系和巨核系细胞Wnt 1、β catenin和E cadherin的表达。对于每个系列,高达10%的染色被接受为阴性,10%及以上的染色被接受为阳性。在原发性血小板增多病例中,巨核系Wnt 1表达显著升高,红细胞系E cadherin表达显著升高(p<0.05)。在三个系列的基础上进行内部评估时,真性红细胞增多症患者红系E - cadherin和E - cadherin表达升高,原发性血小板增多症患者巨核细胞系Wnt - 1表达升高(p<0.05)。未见β连环蛋白表达。因此,我们认为Wnt 1可能与ET病例中的巨核细胞生成有关,E钙粘蛋白可能与ET病例中的红细胞生成有关。然而,在更广泛的骨髓增殖性肿瘤系列中重复研究并评估Wnt通路中的其他因素将是有益的。关键词:原发性血小板增多症,真性红细胞增多症,Wnt 1, β catenin, E cadherin
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引用次数: 0
Hypericum Perforatum Extract Modifies Serum and Tumoral Redox Status and Nitric Oxide Metabolites in Mice 贯叶连翘提取物对小鼠血清和肿瘤氧化还原状态及一氧化氮代谢产物的影响
Pub Date : 2021-06-01 DOI: 10.7176/jstr/7-05-05
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引用次数: 0
The Factors Predicting Pre-service Science Teachers’ Scientific Literacy 职前科学教师科学素养的影响因素
Pub Date : 2021-06-01 DOI: 10.7176/jstr/7-05-02
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引用次数: 0
Abraham in the Old Testament and the New Testament 旧约和新约中的亚伯拉罕
Pub Date : 2021-06-01 DOI: 10.7176/jstr/7-05-04
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引用次数: 0
Re-Ornament of Traditional Architectural Ornament and at the Present-Time the Possibilities of Technology 传统建筑装饰的再装饰与当代技术的可能性
Pub Date : 2021-06-01 DOI: 10.7176/jstr/7-05-03
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引用次数: 0
Excavatability Classification of Rocks around Haroglu Mountain in Northeast of Baskil in Elazig According to Engineering Geology Properties 根据工程地质性质对鄂拉孜格巴什基尔东北部哈罗格鲁山周边岩石可采性进行分类
Pub Date : 2021-03-01 DOI: 10.7176/JSTR/7-02-03
E. Kiliç
Knowledge of the geology of the ground to be excavated in surface mines and foundations, especially in civil engineering works, is very important to decide on the appropriate excavation method and equipment and ensure human and equipment safety with time and cost savings. For this purpose, the engineering geological properties and excavatability classification of rocks around the Haroglu Mountain located in the northeast of Baskil in Elazig were studied. The research started with a desktop study and then continued with a walkover, the determination, and mapping of lithostratigraphic units outcropping in this study area. Yuksekova Formation, Kuscular Formation, Seske Formation, Kirkgecit Formation, and surficial deposits are the lithostratigraphic units in order of occurrence from old to young. Yuksekova Formation, the oldest unit between them, makes up of a group of plutonic, hypabyssal, volcanic, and pyroclastic rocks. After Yuksekova Formation occurs which is magmatic, the sedimentary sequence begins to form with Middle Paleocene-aged rocks. Sedimentary rocks are divided into three formations according to their stratigraphic properties. In order of occurrence from old to young, these sedimentary formations are composed of Kuscular conglomerate, Seske Formation, Kirkgecit Formation. Also, surficial deposits as the youngest unit are formed occasionally over other formations. The structural geological properties of the formations, one of the most important parameters of the excavability, were mapped. The set number, roughness, magnitude of the angle of dip, azimuth of strike or dip of discontinuities or joints, and the block volume are the significant parameters that are influenced excavatability. The azimuths of strikes of discontinuities were measured and carried out the rose diagrams from them. As a result of these measurements, the discontinuities or fractures in Yuksekova Formation have been usually found in the azimuth of a strike having NNE and a 45-90 SW of angle and azimuth of dip. It was determined that the orientation of K60W of excavation is the orientation of a very favorable excavation based on the discontinuity attitudes in the study area. It was established that the orientation of a very unfavorable excavation also is in the azimuth of the strike of fracture, namely N30E. Excavatability of the rocks was determined by assessment of lower and upper discontinuity spacing index and point load strength values. Yuksekova Formation requires methods that can be excavated from very hard to extremely hard ripping (D 9)–blasting by taking into consideration formations exposed in the study area. Kuscular Formation can be excavated by methods of easy ripping (D 6-D 7) to hard ripping (D 8) and Seske Formation also easy ripping (D 6-D 7)-very hard ripping (D 9). Kirkgecit Formation has the capabilities of being excavated by methods of hard digging (CAT 245) to very hard ripping (D 9). As a result of this study, the order of excavatability as the
在露天矿山和基础中,特别是在土木工程中,了解待开挖地面的地质情况,对于确定合适的开挖方法和设备,确保人员和设备的安全,节省时间和成本是非常重要的。为此,对埃拉孜格州巴什基尔东北部哈罗格鲁山周围岩石的工程地质性质和可采性分类进行了研究。研究从桌面研究开始,然后在研究区进行了遍历,确定和绘制了岩石地层单元的露头。由老到新依次为Yuksekova组、Kuscular组、Seske组、kirkgeecit组和表层矿床。尤塞科娃组是它们之间最古老的单位,由一组深成岩、浅成岩、火山岩和火山碎屑岩组成。尤克谢科娃组形成后,开始形成中古新世的沉积层序。沉积岩根据其地层性质分为三组。这些沉积层由老到新依次为Kuscular砾岩、Seske组、kirkgeecit组。此外,表面矿床作为最年轻的单位,偶尔会在其他地层之上形成。构造地质性质是确定可挖掘性的重要参数之一。结构面或节理的倾斜角、走向方位或倾斜角的设置数、粗糙度、大小以及块体体积是影响可采性的重要参数。测量了不连续面走向的方位角,并由此得到了玫瑰图。这些测量结果表明,Yuksekova组的不连续或裂缝通常位于北北东向、倾角和倾角为45-90偏南的走向方位角上。根据研究区不连续走向,确定开挖方向K60W为非常有利的开挖方向。确定了极不利开挖的方位也在裂缝走向的方位角上,即N30E。通过评价上、下不连续间距指数和点荷载强度值来确定岩石的可掘进性。Yuksekova组需要考虑到研究区暴露的地层,可以从极硬撕裂到极硬撕裂(d9)爆破开挖的方法。Kuscular形成可以挖掘的方法简单的转存(D 6 D 7)努力撷取(8 D)和Seske形成也容易转存(D 6 D 7) -非常努力撷取(D 9)。Kirkgecit形成有功能的挖掘方法挖掘245年(CAT)很难很难撕(D 9)。作为本研究的结果,excavatability作为岩石的订单很难简单可以表示为micro-diorite,花岗岩、安山岩,Yuksekova形成的闪长岩,kirkgeecit组砾岩和kusular组砾岩。最后,Kirkgecit组的灰岩和页岩也将分别是最容易挖掘的。此外,还揭示了采用易挖法开采地表矿床的最佳条件。关键词:爆破,开挖,不连续间距指数,可挖性,地层,撕裂,DOI: 10.7176/JSTR/7-02-03
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引用次数: 0
In Vitro Assay and Dissolution Study of Diclofenac Sodium Tablets Marketed In Port Harcourt, South – South Nigeria 尼日利亚南南部哈科特港市售双氯芬酸钠片体外测定及溶出度研究
Pub Date : 2021-01-01 DOI: 10.7176/jstr/7-02-06
The aim of this study is to determine the potency of Diclofenac sodium tablet available in Port Harcourt metropolis, south-south Nigeria. Diclofenac Sodium is a potent Non-Steroidal Anti-Inflammatory Drug (NSAID) commonly used as an Over the Counter (OTC) drug. Potency determination was performed to evaluate and authenticate whether the marketed samples complies with the declared specification. In vitro dissolution study was, performed to verify the potency of the drug and its relative bioavailability. Hardness was checked to verify whether it interferes with the dissolution, which might ultimately affect the drug bioavailability. In this present study, a simple, cost effective, and spectrophotometric method for the potency determination of marketed diclofenac sodium tablets is used. Six samples were randomly collected from the market and coded as A, B, C, D, E and F, and the potency determined are 80%, 98.7%, 126.9%, 99.6%, 109.2% and 91.4% respectively. Hardness and in vitro dissolution of the six brands of diclofenac sodium tablet were studied and reported. After 1 h dissolution release of samples A, B, C, D, E, and F are 135%, 30%, 70%, 122%, 38%, and 40% respectively. The results obtained from the study signified, that not all the samples analyzed complied with the BP and USP standards or requirements.
本研究的目的是确定尼日利亚南南哈科特港市双氯芬酸钠片的效价。双氯芬酸钠是一种有效的非甾体抗炎药(NSAID),通常作为非处方(OTC)药物使用。效价测定是为了评估和验证上市样品是否符合声明的规格。体外溶出度研究验证了该药物的效价和相对生物利用度。检查硬度以验证其是否干扰溶出,这可能最终影响药物的生物利用度。本研究采用一种简单、经济、高效的分光光度法测定市售双氯芬酸钠片的效价。随机抽取市场样品6份,编码为A、B、C、D、E、F,测定效价分别为80%、98.7%、126.9%、99.6%、109.2%、91.4%。对6种牌子双氯芬酸钠片的硬度和体外溶出度进行了研究。样品A、B、C、D、E、F溶出1 h后的释放度分别为135%、30%、70%、122%、38%、40%。研究结果表明,并非所有分析的样品都符合BP和USP的标准或要求。
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引用次数: 0
Financial Development and Income Inequality Relationship: Analyzing Financial Kuznets Curve with ARDL Boundary Test in Turkey 金融发展与收入不平等关系:用ARDL边界检验分析土耳其金融库兹涅茨曲线
Pub Date : 2021-01-01 DOI: 10.7176/jstr/7-01-07
Seyma Yilmaz Kuscuoglu, Macide Çiçek
In this study, the relationship between the financial development and the income inequality in Turkey is investigated by testing the validity of Financial Kuznets Curve Hypothesis. To examine this relationship for the period of 1987 2017, the variables of the public final consumption expenditures, the modern sector share, the inflation and the human capitalare also added to the model setted as control variables, and the long term relationships among the variables are analyzed by using the ARDL (The Autoregressive Distributed Lag) Boundary Test approach. Empirical evidence refers to the validity of the Financial Kuznets Curve Hypothesis in Turkey, in other words, there is an inverse U shaped relationship between the financial development and the income inequality. Accordingly, while the financial development raises the inequality in income distribution to a certain threshold level, it reduces the inequality after this threshold level in Turkey. Moreover, in the long run increases in the modern sector share, the public final consumption expenditures and in the trade openness help to reducing income inequality but increases in the inflation and in the human capital make worse income inequality. Keywords: Financial Development, Income Inequality, Financial Kuznets Curve, ARDL Boundary Test. DOI: 10.7176/JSTR/7-01-07
本研究通过检验金融库兹涅茨曲线假设的有效性,考察土耳其金融发展与收入不平等之间的关系。为了检验1987 - 2017年期间的这种关系,将公共最终消费支出、现代部门份额、通货膨胀和人力资本作为控制变量加入到模型中,并采用自回归分布滞后(ARDL)边界检验方法分析变量之间的长期关系。经验证据指的是土耳其金融库兹涅茨曲线假说的有效性,即金融发展与收入不平等之间存在倒U型关系。因此,在土耳其,金融发展在将收入分配不平等提升到一定阈值水平的同时,也降低了该阈值之后的不平等。此外,从长期来看,现代部门份额、公共最终消费支出和贸易开放的增加有助于减少收入不平等,但通货膨胀和人力资本的增加会加剧收入不平等。关键词:金融发展,收入不平等,金融库兹涅茨曲线,ARDL边界检验DOI: 10.7176 / JSTR / 7-01-07
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引用次数: 2
期刊
International Journal of Scientific and Technological Research
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