Myocardial ischemia refers to the condition in which a portion of a heart is starved of oxygen and nutrients as a result of sudden block i the coronary arteries. It may be caused by chemotherapy, complications from anorexia nervosa , adverse effects of heavy metals intake and an incorrectly administered drug.The aim of the study is to investigate the protective role of Ascidia sydneiensis in isoproterenol - induced myocardial ischemia in rats. The extract was administered at a dose of 50, 100 and 150 mg/kg bw i.g.c for 28 days. The animals of ISO control and Ascidia sydneiensis pretreated groups were given isoproterenol (150 mg/kg bw) at an interval of 24 hours on 29 th and 30 th day of the experiment. Biochemical parameters like LDH, AST, ALT in serum and lipid peroxidation marker enzyme - MDA in both serum and tissue; enzymatic and non-enzymatic myocardial antioxidant enzymes - SOD, CAT, GPx in heart tissue and GSH in both serum and tissue were analysed following standard procedures. Histopathological architecture of cardiac muscle was also studied. A significant increase in the level of LDH, AST, ALT in the serum and lipid peroxidation marker enzyme - MDA in serum and heart tissue and decrease in the enzymatic and non-enzymatic antioxidant enzymes - SOD, CAT, GPx in heart tissue and GSH in both serum and tissue were noted in ISO treated groups. In the pretreated groups all the above parameters were normal. Restoration of enzyme level observed in the co-treated groups indicate that the extract has protective role in ISO - induced myocardial ischemia. Histopathological studies also confirmed the protective nature of the extract on heart tissue. Based on present findings, it is concluded that Ascidia sydneiensis may be a potential and therapeutic agent against the oxidative stress associated ischemic heart disease owing to antioxidant and antiperoxidative activity.
{"title":"Protective role of Ascidia sydneiensis Stimpson, 1855 on cardiac enzyme biochemistry and histopathology in isoproterenol - induced myocardial ischemia","authors":"C. Packiam, R. Margret, V. Meenakshi","doi":"10.7439/IJPC.V7I1.3857","DOIUrl":"https://doi.org/10.7439/IJPC.V7I1.3857","url":null,"abstract":"Myocardial ischemia refers to the condition in which a portion of a heart is starved of oxygen and nutrients as a result of sudden block i the coronary arteries. It may be caused by chemotherapy, complications from anorexia nervosa , adverse effects of heavy metals intake and an incorrectly administered drug.The aim of the study is to investigate the protective role of Ascidia sydneiensis in isoproterenol - induced myocardial ischemia in rats. The extract was administered at a dose of 50, 100 and 150 mg/kg bw i.g.c for 28 days. The animals of ISO control and Ascidia sydneiensis pretreated groups were given isoproterenol (150 mg/kg bw) at an interval of 24 hours on 29 th and 30 th day of the experiment. Biochemical parameters like LDH, AST, ALT in serum and lipid peroxidation marker enzyme - MDA in both serum and tissue; enzymatic and non-enzymatic myocardial antioxidant enzymes - SOD, CAT, GPx in heart tissue and GSH in both serum and tissue were analysed following standard procedures. Histopathological architecture of cardiac muscle was also studied. A significant increase in the level of LDH, AST, ALT in the serum and lipid peroxidation marker enzyme - MDA in serum and heart tissue and decrease in the enzymatic and non-enzymatic antioxidant enzymes - SOD, CAT, GPx in heart tissue and GSH in both serum and tissue were noted in ISO treated groups. In the pretreated groups all the above parameters were normal. Restoration of enzyme level observed in the co-treated groups indicate that the extract has protective role in ISO - induced myocardial ischemia. Histopathological studies also confirmed the protective nature of the extract on heart tissue. Based on present findings, it is concluded that Ascidia sydneiensis may be a potential and therapeutic agent against the oxidative stress associated ischemic heart disease owing to antioxidant and antiperoxidative activity.","PeriodicalId":14317,"journal":{"name":"International Journal of Pharmaceutical Chemistry","volume":"13 1","pages":"11-19"},"PeriodicalIF":0.0,"publicationDate":"2017-02-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83735051","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
B. Dash, S. Dash, Damiki Laloo, Jashabir Chakraborty
Objective: The present investigation is designed to synthesize some new isomeric series of quinazoline-4-one/4-thione derivatives, depending upon on the pharmacophoric model of in-vivo anticancer activity by modifying the structures retaining the fundamental structural features for the activity and screened for their antitumor properties. Methods: A new series of 7-chloro-3-[substituted (amino/phenyl amino)]-2-phenyl quinazolin-4 (3H)-one/thione derivatives and 1-(7-chloro-4-oxo/-2-phenylquinazoline-3 (4H-yl)) substituted urea derivatives were synthesized. The reaction scheme proceeds through 7-chloro-2-phenyl-4H-benzo [d] [1, 3] oxazin-4-one which is the intermediate one. The structures of the newly synthesized compounds were characterised from infrared (IR), H 1 nuclear magnetic resonance (NMR) and mass spectra (m/z) and elemental analysis. The in-vivo antitumor activity was evaluated by body weight analysis, mean survival time and percentage increase in life span methods in Swiss albino mice bearing Ehrilich ascites carcinoma (EAC). Result: The physico-chemical and spectroscopic data established the synthesis of quinazoline derivatives with a common pharmacophore. The synthesized compounds were evaluated for their antitumor properties. Among the newly quinazoline derivatives screened, six compounds (IIh, IIi, IIj, IIIh, IIIi, IIIj)) have shown significant antitumor activity. Conclusion: The quinazoline derivatives obtained from the present study indicates that the amino group at 3 rd position and urea/thiourea group in phenyl hydrazine ring at 3 rd position of quinzoline skeleton are essential for antitumor activity. Compounds IIh, IIi, IIj, IIIh, IIIi and IIIj were found to be biologically active which may be useful as potential resource for the discovery of anti-tumor compound having common quinazoline pharmacophore with lesser toxic effects.
{"title":"Design, synthesis and in vivo antitumor activity of novel 3, 4 di-substituted quinazoline derivatives","authors":"B. Dash, S. Dash, Damiki Laloo, Jashabir Chakraborty","doi":"10.7439/ijpc.v7i1.3928","DOIUrl":"https://doi.org/10.7439/ijpc.v7i1.3928","url":null,"abstract":"Objective: The present investigation is designed to synthesize some new isomeric series of quinazoline-4-one/4-thione derivatives, depending upon on the pharmacophoric model of in-vivo anticancer activity by modifying the structures retaining the fundamental structural features for the activity and screened for their antitumor properties. Methods: A new series of 7-chloro-3-[substituted (amino/phenyl amino)]-2-phenyl quinazolin-4 (3H)-one/thione derivatives and 1-(7-chloro-4-oxo/-2-phenylquinazoline-3 (4H-yl)) substituted urea derivatives were synthesized. The reaction scheme proceeds through 7-chloro-2-phenyl-4H-benzo [d] [1, 3] oxazin-4-one which is the intermediate one. The structures of the newly synthesized compounds were characterised from infrared (IR), H 1 nuclear magnetic resonance (NMR) and mass spectra (m/z) and elemental analysis. The in-vivo antitumor activity was evaluated by body weight analysis, mean survival time and percentage increase in life span methods in Swiss albino mice bearing Ehrilich ascites carcinoma (EAC). Result: The physico-chemical and spectroscopic data established the synthesis of quinazoline derivatives with a common pharmacophore. The synthesized compounds were evaluated for their antitumor properties. Among the newly quinazoline derivatives screened, six compounds (IIh, IIi, IIj, IIIh, IIIi, IIIj)) have shown significant antitumor activity. Conclusion: The quinazoline derivatives obtained from the present study indicates that the amino group at 3 rd position and urea/thiourea group in phenyl hydrazine ring at 3 rd position of quinzoline skeleton are essential for antitumor activity. Compounds IIh, IIi, IIj, IIIh, IIIi and IIIj were found to be biologically active which may be useful as potential resource for the discovery of anti-tumor compound having common quinazoline pharmacophore with lesser toxic effects.","PeriodicalId":14317,"journal":{"name":"International Journal of Pharmaceutical Chemistry","volume":"18 1","pages":"20-30"},"PeriodicalIF":0.0,"publicationDate":"2017-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81850960","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Nicotine is an important class of heterocyclic compound, has been shown to exhibit diverse biological and pharmacological activities. In this study, a series of newer 2-amino nicotinate derivativeshave been synthesized by Baylis Hillman reaction. All the synthesized compounds have been characterized by using elemental analysis, FT-IR, 1 H NMR, 13 C NMR spectroscopy and further supported by mass spectroscopy. Purity of all the compounds has been checked on thin layer chromatographic plate and HPLC technique. All the synthesized compounds were tested for their analgesic and anti-inflammatory activities. The compounds exhibited significant analgesic and anti-inflammatory activities. These compounds can be further exploited to get the potent lead compounds. The detailed synthesis and the pharmacological screening of 2-amino nicotinate derivatives are reported.
{"title":"Analgesic and antiinflammatory evaluation of newer 2-amino nicotinate derivatives synthesized by baylis hillman reaction","authors":"K. Ch., G. Raju, R. Nadendla","doi":"10.7439/ijpc.v7i1.3875","DOIUrl":"https://doi.org/10.7439/ijpc.v7i1.3875","url":null,"abstract":"Nicotine is an important class of heterocyclic compound, has been shown to exhibit diverse biological and pharmacological activities. In this study, a series of newer 2-amino nicotinate derivativeshave been synthesized by Baylis Hillman reaction. All the synthesized compounds have been characterized by using elemental analysis, FT-IR, 1 H NMR, 13 C NMR spectroscopy and further supported by mass spectroscopy. Purity of all the compounds has been checked on thin layer chromatographic plate and HPLC technique. All the synthesized compounds were tested for their analgesic and anti-inflammatory activities. The compounds exhibited significant analgesic and anti-inflammatory activities. These compounds can be further exploited to get the potent lead compounds. The detailed synthesis and the pharmacological screening of 2-amino nicotinate derivatives are reported.","PeriodicalId":14317,"journal":{"name":"International Journal of Pharmaceutical Chemistry","volume":"123 1","pages":"31-36"},"PeriodicalIF":0.0,"publicationDate":"2017-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76234138","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Xianfeng Huang, Yuanyuan Liu, Cheng Zhang, Guoqiang Song
A novel class of ferulic acid derivatives with urea groups were synthesized and evaluated for hypoglycemic and aldose reductase inhibition activities. Several compounds showed comparable in vivo hypoglycemic agents to the commercial drug glibenclamide. Furthermore, of the tested compounds, 7a and 7 b displayed the most potent aldose reductase inhibitory activity in vitro , with an IC 50 of 0.55 and 3.88 M, respectively. Docking simulation was performed to insert compound 7a and 12a into the crystal structure of aldose reductase at active site to determine the probable binding model.
{"title":"Synthesis, hypoglycemic and aldose reductase inhibition activity of novel ferulic acid derivatives","authors":"Xianfeng Huang, Yuanyuan Liu, Cheng Zhang, Guoqiang Song","doi":"10.7439/IJPC.V7I1.3798","DOIUrl":"https://doi.org/10.7439/IJPC.V7I1.3798","url":null,"abstract":"A novel class of ferulic acid derivatives with urea groups were synthesized and evaluated for hypoglycemic and aldose reductase inhibition activities. Several compounds showed comparable in vivo hypoglycemic agents to the commercial drug glibenclamide. Furthermore, of the tested compounds, 7a and 7 b displayed the most potent aldose reductase inhibitory activity in vitro , with an IC 50 of 0.55 and 3.88 M, respectively. Docking simulation was performed to insert compound 7a and 12a into the crystal structure of aldose reductase at active site to determine the probable binding model.","PeriodicalId":14317,"journal":{"name":"International Journal of Pharmaceutical Chemistry","volume":"43 1","pages":"01-10"},"PeriodicalIF":0.0,"publicationDate":"2017-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91354640","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Rajesh Kumar, Manoj Kumar, C. Sharma, K. R. Aneja, O. Prakash
Pyrazolyl isoxazolines were synthesized by 1,3-dipolar cycloaddition of pyrazolyl nitrile oxide with various activated alkene such as acrylonitrile, methyl acrylate and vinyl acetate in the presence of iodobenzene diacetate in methanol containing a catalytic amount of TFA at room temperature with an aim to explore their effect on in vitro growth of microorganism causing microbial infection. Eleven compounds were tested in vitro for their antibacterial activity against two Gram-positive bacteria namely, Staphylococcus aureus , Bacillus subtilis and two Gram-negative bacteria namely, Escherichia coli and Pseudomonas aeruginosa . All the synthesized compounds were also tested for their inhibitory action against two strains of fungus.
{"title":"Synthesis and Biological Evaluation of Pyrazolyl Isoxazolines as Antimicrobial Agents","authors":"Rajesh Kumar, Manoj Kumar, C. Sharma, K. R. Aneja, O. Prakash","doi":"10.7439/IJPC.V6I12.3610","DOIUrl":"https://doi.org/10.7439/IJPC.V6I12.3610","url":null,"abstract":"Pyrazolyl isoxazolines were synthesized by 1,3-dipolar cycloaddition of pyrazolyl nitrile oxide with various activated alkene such as acrylonitrile, methyl acrylate and vinyl acetate in the presence of iodobenzene diacetate in methanol containing a catalytic amount of TFA at room temperature with an aim to explore their effect on in vitro growth of microorganism causing microbial infection. Eleven compounds were tested in vitro for their antibacterial activity against two Gram-positive bacteria namely, Staphylococcus aureus , Bacillus subtilis and two Gram-negative bacteria namely, Escherichia coli and Pseudomonas aeruginosa . All the synthesized compounds were also tested for their inhibitory action against two strains of fungus.","PeriodicalId":14317,"journal":{"name":"International Journal of Pharmaceutical Chemistry","volume":"515 1","pages":"245-253"},"PeriodicalIF":0.0,"publicationDate":"2016-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80098876","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Antimicrobial analysis and structural elucidation were carried out on the purified leaves of Dialium indum. The Harbone method was used for the extraction. The extracts were separated using a combination of column chromatography and thin layer chromatography, which gave rise to the isolation of two fractions, these fractions were further purified using recrystallization. The melting point of each pure fraction was determined. The purified extracts were subjected to structural elucidation using various spectroscopic techniques which includes; FTIR, UV, H1 NMR, C13 NMR, DEPT 1350, COSY, TOCSY, HMBC and HSQC . The spectral analysis suggested the presence of Stigmasterol, and Lauric acid. The antimicrobial analysis (anti fungal and anti bacterial analysis) using the punched agar diffusion method was carried out on the isolated fractions comparatively with a standard drug Funbact-A cream (a broad spectrum antibiotic). A total of thirteen test organisms were used for this analysis amongst which were ten bacteria test organism and three fungi test organisms. The results from the average diameter zones of inhibition, minimum inhibitory concentration (MIC), minimum bactericidal concentration (MBC) and fungicidal concentrations (MFC) showed that all the fractions were all active on the entire test organism with zones of inhibition ranging from 14mm-36mm comparatively. None of these fractions showed similar antimicrobial effect as the standard drug Funbact-A cream but individually could serve as anti microbial to diseases caused by these test organisms from their MIC, MBC and MFC.
{"title":"Antimicrobial Analysis and Structural Elucidation Of Active Compounds Of Dialium Indum Leaves Extract (Valvet Tarmarind)","authors":"K. I. Ijoma, V. Ajiwe, C. I. Awuzie","doi":"10.7439/IJPC.V6I12.3658","DOIUrl":"https://doi.org/10.7439/IJPC.V6I12.3658","url":null,"abstract":"Antimicrobial analysis and structural elucidation were carried out on the purified leaves of Dialium indum. The Harbone method was used for the extraction. The extracts were separated using a combination of column chromatography and thin layer chromatography, which gave rise to the isolation of two fractions, these fractions were further purified using recrystallization. The melting point of each pure fraction was determined. The purified extracts were subjected to structural elucidation using various spectroscopic techniques which includes; FTIR, UV, H1 NMR, C13 NMR, DEPT 1350, COSY, TOCSY, HMBC and HSQC . The spectral analysis suggested the presence of Stigmasterol, and Lauric acid. The antimicrobial analysis (anti fungal and anti bacterial analysis) using the punched agar diffusion method was carried out on the isolated fractions comparatively with a standard drug Funbact-A cream (a broad spectrum antibiotic). A total of thirteen test organisms were used for this analysis amongst which were ten bacteria test organism and three fungi test organisms. The results from the average diameter zones of inhibition, minimum inhibitory concentration (MIC), minimum bactericidal concentration (MBC) and fungicidal concentrations (MFC) showed that all the fractions were all active on the entire test organism with zones of inhibition ranging from 14mm-36mm comparatively. None of these fractions showed similar antimicrobial effect as the standard drug Funbact-A cream but individually could serve as anti microbial to diseases caused by these test organisms from their MIC, MBC and MFC.","PeriodicalId":14317,"journal":{"name":"International Journal of Pharmaceutical Chemistry","volume":"23 1","pages":"237-244"},"PeriodicalIF":0.0,"publicationDate":"2016-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77854324","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The present study was undertaken to evaluate cardiotonic activity of aqueous extract of whole plant of carmona retusa (vahl) masam. Phytochemical screening of whole plant material revealed that the major constituent of Carmon retusa (Vahl.) Masam plant is an intractable mixture of alkaloids,triterpenes, flavanoids and cardiac gylcosides. Cardiotonic effect of aqueous extract of whole plant of carmona retusa was studied by using isolated frog heart perfusion technique (IFHP). Calcium free Ringer solution was used as vehicle for administration of aqueous extract of carmona retusa as a test extract and digoxin as a standard. A significant increase in height of force of contraction (positive inotropic effect) and decrease in heart rate (negative chronotropic effect) at a very low concentration (10g/ml) was observed with test extract as compared to the same dose of a standard digoxin. The present results indicated that a significant increase in height of force of contraction with decrease in heart rate was observed as the dose of test extract increased. The test extract does not produced cardiac arrest at 80g/ml, a higher concentration, as compared to standard, digoxin, a drug with narrow therapeutic window, carmona retusa showed wide therapeutic window.
{"title":"Phytochemical Screening, Spectroscpic Characterisation and Cardiotonic Activity of Aqueous Extract from Arieal Parts of Carmona Retusa (Vahl) Masam on Isolated Frogs Heart","authors":"G. Kumar, A. Rani, B. Pooja, Y. Kumar","doi":"10.7439/IJPC.V6I12.3804","DOIUrl":"https://doi.org/10.7439/IJPC.V6I12.3804","url":null,"abstract":"The present study was undertaken to evaluate cardiotonic activity of aqueous extract of whole plant of carmona retusa (vahl) masam. Phytochemical screening of whole plant material revealed that the major constituent of Carmon retusa (Vahl.) Masam plant is an intractable mixture of alkaloids,triterpenes, flavanoids and cardiac gylcosides. Cardiotonic effect of aqueous extract of whole plant of carmona retusa was studied by using isolated frog heart perfusion technique (IFHP). Calcium free Ringer solution was used as vehicle for administration of aqueous extract of carmona retusa as a test extract and digoxin as a standard. A significant increase in height of force of contraction (positive inotropic effect) and decrease in heart rate (negative chronotropic effect) at a very low concentration (10g/ml) was observed with test extract as compared to the same dose of a standard digoxin. The present results indicated that a significant increase in height of force of contraction with decrease in heart rate was observed as the dose of test extract increased. The test extract does not produced cardiac arrest at 80g/ml, a higher concentration, as compared to standard, digoxin, a drug with narrow therapeutic window, carmona retusa showed wide therapeutic window.","PeriodicalId":14317,"journal":{"name":"International Journal of Pharmaceutical Chemistry","volume":"16 1","pages":"230-236"},"PeriodicalIF":0.0,"publicationDate":"2016-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87415909","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
P. Salunke, K. Ingale, Pooja Gondhankhede, Kanchan Ghate, S. S. Patil, S. Barhate
A simple, rapid, accurate and precise UV method was developed and validated for the estimation of Itraconazole in pharmaceutical dosage form. Spectroscopic method was carried out by using acidic ethanol as solvent. Itraconazole detection wavelength was set at 262nm for validation purpose linearity, accuracy, repeatability, precision, LOD, LOQ, and ruggedness parameters were studied. The linearity was found to be in the range of 2-12 g/ml.
{"title":"UV-Visible Spectrophotometric Method Development and Validation of Itraconazole in Bulk and Capsule Formulation","authors":"P. Salunke, K. Ingale, Pooja Gondhankhede, Kanchan Ghate, S. S. Patil, S. Barhate","doi":"10.7439/IJAPA.V6I4.3833","DOIUrl":"https://doi.org/10.7439/IJAPA.V6I4.3833","url":null,"abstract":"A simple, rapid, accurate and precise UV method was developed and validated for the estimation of Itraconazole in pharmaceutical dosage form. Spectroscopic method was carried out by using acidic ethanol as solvent. Itraconazole detection wavelength was set at 262nm for validation purpose linearity, accuracy, repeatability, precision, LOD, LOQ, and ruggedness parameters were studied. The linearity was found to be in the range of 2-12 g/ml.","PeriodicalId":14317,"journal":{"name":"International Journal of Pharmaceutical Chemistry","volume":"176 1","pages":"21-26"},"PeriodicalIF":0.0,"publicationDate":"2016-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77476955","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
An isocratic reversed phase stability-indicating high-performance liquid chromatographic (HPLC) assay method was developed and validated for quantitative determination of Meclizine HCl in bulk drugs. An isocratic, reversed phase HPLC method was developed to separate the drug from the degradation products, using a Water Nova Pack C18 (250 x 4.6) mm, 5? column and the mobile phase containing 1.0 gm Sodium dihydrogen phosphate and 1.0 gm 1-octaneSulfonic acid salt in 1000ml water filter and mixed. Prepare a homogenous mixture of buffer, methanol and acetonitile. The detection was carried out at wavelength 264 nm. The developed method was validated with respect to linearity, accuracy (recovery), precision, system suitability, selectivity, robustness prove the stability indicating ability of the method.
{"title":"A validated stability-indicating HPLC assay method for Meclizine HCl in bulk drug","authors":"M. Ubale, M. Shioorkar, V. Choudhari","doi":"10.7439/IJAPA.V6I3.3855","DOIUrl":"https://doi.org/10.7439/IJAPA.V6I3.3855","url":null,"abstract":"An isocratic reversed phase stability-indicating high-performance liquid chromatographic (HPLC) assay method was developed and validated for quantitative determination of Meclizine HCl in bulk drugs. An isocratic, reversed phase HPLC method was developed to separate the drug from the degradation products, using a Water Nova Pack C18 (250 x 4.6) mm, 5? column and the mobile phase containing 1.0 gm Sodium dihydrogen phosphate and 1.0 gm 1-octaneSulfonic acid salt in 1000ml water filter and mixed. Prepare a homogenous mixture of buffer, methanol and acetonitile. The detection was carried out at wavelength 264 nm. The developed method was validated with respect to linearity, accuracy (recovery), precision, system suitability, selectivity, robustness prove the stability indicating ability of the method.","PeriodicalId":14317,"journal":{"name":"International Journal of Pharmaceutical Chemistry","volume":"66 1","pages":"16-20"},"PeriodicalIF":0.0,"publicationDate":"2016-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80215244","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Series of oxazepine derivatives were synthesized from Schiffs base as aldehyde derivatives by using semicarbazide as starting material.Then equimolar quantities of prepared Schiffs base reacts with pthallic anhydride or succinic anhydride undergo cycloaddition reaction in the presence of organic solvent benzene give an oxazepine ring system. Chemical structures of the synthesized compounds were confirmed on the basis of their spectral data
{"title":"Synthesis and physico-chemical characterization of some novel oxazepine derivatives","authors":"L. Joseph, M. George, Surekha","doi":"10.7439/IJPC.V6I11.3713","DOIUrl":"https://doi.org/10.7439/IJPC.V6I11.3713","url":null,"abstract":"Series of oxazepine derivatives were synthesized from Schiffs base as aldehyde derivatives by using semicarbazide as starting material.Then equimolar quantities of prepared Schiffs base reacts with pthallic anhydride or succinic anhydride undergo cycloaddition reaction in the presence of organic solvent benzene give an oxazepine ring system. Chemical structures of the synthesized compounds were confirmed on the basis of their spectral data","PeriodicalId":14317,"journal":{"name":"International Journal of Pharmaceutical Chemistry","volume":"87 1","pages":"224-229"},"PeriodicalIF":0.0,"publicationDate":"2016-11-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84040587","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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