Eman Khaled, Juhi Godara, G. Alrais, Asra'a Alnakeb
This comprehensive narrative review elucidates the complexities surrounding menopausal hormone therapy (MHT), encompassing diverse symptom management strategies and associated risks. It explores the dynamic landscape of hormonal and non-hormonal approaches, integrating recent primary evidence and updated recommendations from specialized medical societies. Menopause, a critical phase in women's lives, is examined through its multifaceted physiological changes and the impact of MHT on symptomatology and long-term health outcomes. Additionally, the review delves into alternative therapies, emphasizing personalized care and tailored interventions for managing menopausal symptoms effectively
{"title":"MENOPAUSAL HORMONE THERAPY AND SYMPTOM MANAGEMENT: A COMPREHENSIVE REVIEW","authors":"Eman Khaled, Juhi Godara, G. Alrais, Asra'a Alnakeb","doi":"10.36106/ijsr/3220352","DOIUrl":"https://doi.org/10.36106/ijsr/3220352","url":null,"abstract":"This comprehensive narrative review elucidates the complexities surrounding menopausal hormone therapy (MHT), encompassing diverse\u0000symptom management strategies and associated risks. It explores the dynamic landscape of hormonal and non-hormonal approaches, integrating\u0000recent primary evidence and updated recommendations from specialized medical societies. Menopause, a critical phase in women's lives, is\u0000examined through its multifaceted physiological changes and the impact of MHT on symptomatology and long-term health outcomes.\u0000Additionally, the review delves into alternative therapies, emphasizing personalized care and tailored interventions for managing menopausal\u0000symptoms effectively","PeriodicalId":14358,"journal":{"name":"International journal of scientific research","volume":"14 4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141134151","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The Enhanced Recovery After Surgery (ERAS) route was created to help patients following major surgery recover more quickly. Three crucial elements include the preoperative, intraoperative, and postoperative regimens.Early eating, opioid-free multimodal pain treatment, and euvolemia are just a few of the elements that make up enhanced recovery protocols, which all work together to speed postoperative recovery. In order to optimize patient care, pre- and post-habilitation are crucial. The results for patients signicantly improved once the ERAS was implemented, and the overall cost of treatment decreased. Evidence-based medicine is the foundation of the ERAS. In this review, we summarized the most recent data on ERAS and how it benets the patient.
{"title":"ENHANCED RECOVERY AFTER SURGERY IN GYNECOLOGY","authors":"Hala El Sayed Ali Hassan","doi":"10.36106/ijsr/3520436","DOIUrl":"https://doi.org/10.36106/ijsr/3520436","url":null,"abstract":"The Enhanced Recovery After Surgery (ERAS) route was created to help patients following major surgery recover more quickly. Three crucial\u0000elements include the preoperative, intraoperative, and postoperative regimens.Early eating, opioid-free multimodal pain treatment, and\u0000euvolemia are just a few of the elements that make up enhanced recovery protocols, which all work together to speed postoperative recovery. In\u0000order to optimize patient care, pre- and post-habilitation are crucial. The results for patients signicantly improved once the ERAS was\u0000implemented, and the overall cost of treatment decreased. Evidence-based medicine is the foundation of the ERAS. In this review, we summarized\u0000the most recent data on ERAS and how it benets the patient.","PeriodicalId":14358,"journal":{"name":"International journal of scientific research","volume":"47 10","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141142195","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Yugam Rajeshkumar Oza, H. M. Joshi, Sameeha Fatima Khan, Amna Shahid Bilal, Ali Zeeshan Murtuza, Vidhi Mashru
Intestinal failure associated with liver disease (IFALD) is an intricate illness having the prevalence of 40-60% in paediatric population and 15-40% in adults [1]. The diseases corresponding with liver include cholestasis, gall bladder disease, steatohepatitis, and biliary cirrhosis [1]. Since IFALD has a complicated etiology there are many factors causing it but parenteral administration (PN) remains the key reason. Each patient of a different age group presents with varying symptoms and signs, so the treatment strategy is tailored accordingly. This review encompasses the risk factors causing IFALD along with the intricate pathogenesis, the changes that can be bought in our diet to prevent it from occurring and last most importantly the management techniques along with the line of treatment.
{"title":"FROM BOWELS TO BILIRUBIN UNRAVELING THE MECHANISM OF INTESTINAL FAILURE ASSOCIATED LIVER DISEASE: A NARRATIVE REVIEW","authors":"Yugam Rajeshkumar Oza, H. M. Joshi, Sameeha Fatima Khan, Amna Shahid Bilal, Ali Zeeshan Murtuza, Vidhi Mashru","doi":"10.36106/ijsr/8208926","DOIUrl":"https://doi.org/10.36106/ijsr/8208926","url":null,"abstract":"Intestinal failure associated with liver disease (IFALD) is an intricate illness having the prevalence of 40-60% in paediatric population and 15-40%\u0000in adults [1]. The diseases corresponding with liver include cholestasis, gall bladder disease, steatohepatitis, and biliary cirrhosis [1]. Since IFALD\u0000has a complicated etiology there are many factors causing it but parenteral administration (PN) remains the key reason. Each patient of a different\u0000age group presents with varying symptoms and signs, so the treatment strategy is tailored accordingly. This review encompasses the risk factors\u0000causing IFALD along with the intricate pathogenesis, the changes that can be bought in our diet to prevent it from occurring and last most\u0000importantly the management techniques along with the line of treatment.","PeriodicalId":14358,"journal":{"name":"International journal of scientific research","volume":"24 32","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141136861","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Background: Dengue a vector borne disease considered hazard to public health. Diagnosis is by dengue specic antigen and antibody detection. Decrease in platelet count consider as warning sign in dengue positive cases. Hence this study was done to correlate various dengue parameter and platelet count. Material and Methods: A Retrospective analytical study conducted from period of September 2022- September 2023.A total of 1670 serum samples tested for dengue using ICTkit , 82 samples were tested positive. Platelet count recorded for all the cases. Results: 1670 serum sample tested for dengue, 82 sample tested positive for dengue antigen or antibody by ICT based test. Thrombocytopenia (platelet count < 100,000/ml) observed in 20 cases. Association of thrombocytopenia in dengue positive cases was more signicant as compared to dengue negative cases. Conclusion: A necessary to provide association of thrombocytopenia and various dengue markers to physician in management of dengue infection, which further help in reducing complications as thrombocytopenia association in dengue case was signicant as compared to other dengue negative cases.
{"title":"UNLOCKING THE LINK: DENGUE SEROLOGICAL MARKER AND PLATELET DYNAMICS","authors":"Prakash Narayan Gupta, Bhagya Babu","doi":"10.36106/ijsr/3408101","DOIUrl":"https://doi.org/10.36106/ijsr/3408101","url":null,"abstract":"Background: Dengue a vector borne disease considered hazard to public health. Diagnosis is by dengue specic antigen and antibody detection.\u0000Decrease in platelet count consider as warning sign in dengue positive cases. Hence this study was done to correlate various dengue parameter and\u0000platelet count. Material and Methods: A Retrospective analytical study conducted from period of September 2022- September 2023.A total of\u00001670 serum samples tested for dengue using ICTkit , 82 samples were tested positive. Platelet count recorded for all the cases. Results: 1670 serum\u0000sample tested for dengue, 82 sample tested positive for dengue antigen or antibody by ICT based test. Thrombocytopenia (platelet count <\u0000100,000/ml) observed in 20 cases. Association of thrombocytopenia in dengue positive cases was more signicant as compared to dengue negative\u0000cases. Conclusion: A necessary to provide association of thrombocytopenia and various dengue markers to physician in management of dengue\u0000infection, which further help in reducing complications as thrombocytopenia association in dengue case was signicant as compared to other\u0000dengue negative cases.","PeriodicalId":14358,"journal":{"name":"International journal of scientific research","volume":" 29","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141130790","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Background: Increasing rate of musculoskeletal dysfunction due to backpack is matter of concern. Prevalence varies regionally as it depends on many variables. Heavy backpack is one of the important underlying causes. Adolescent spine is in the critical stage of development in the age group of 07-15 years. This study was carried out to decide regional cutoffs of heavy relative weights of backpacks in male and female children. Methodology: For this survey, a sample of students from Ahmedabad's New Education School was used. Every student who satises the inclusion requirements is welcome to take part in the research. Through the semi-structured questionnaire, the data were collected. The length of the trip, the type of vehicle, and the distance traveled, the posture taken while traveling, and the level of pain were all mentioned in the questionnaires. Every outcome that was measured was obtained at baseline. NDI, SPADI & NPRS. In present study we found th Result: at from total 60 students 34 students shows highest upper cross syndrome and students with upper cross syndrome were having mean pain score of NPRS 4.52±2.18 and disability as per NDI & SPADI as 50.79 &51.28.overall prevalence of musculoskeletal dysfunction is 55.66%. Majority of the Conclusions: School going students are exposed to the risk of adopting poor postures which can lead to musculoskeletal dysfunction. The results of this study suggesting the importance of postural awareness among school going students.
{"title":"PREVALENCE OF MUSCULOSKELETAL DYSFUNCTION DUE TO BACKPACKS IN STUDENTS WITH UPPER CROSS SYNDROME","authors":"Bushra N Shaikh, Drashti Shah, Arvind Kumar","doi":"10.36106/ijsr/7906921","DOIUrl":"https://doi.org/10.36106/ijsr/7906921","url":null,"abstract":"Background: Increasing rate of musculoskeletal dysfunction due to backpack is matter of concern. Prevalence varies regionally as it depends on\u0000many variables. Heavy backpack is one of the important underlying causes. Adolescent spine is in the critical stage of development in the age group\u0000of 07-15 years. This study was carried out to decide regional cutoffs of heavy relative weights of backpacks in male and female children.\u0000Methodology: For this survey, a sample of students from Ahmedabad's New Education School was used. Every student who satises the inclusion\u0000requirements is welcome to take part in the research. Through the semi-structured questionnaire, the data were collected. The length of the trip, the\u0000type of vehicle, and the distance traveled, the posture taken while traveling, and the level of pain were all mentioned in the questionnaires. Every\u0000outcome that was measured was obtained at baseline. NDI, SPADI & NPRS. In present study we found th Result: at from total 60 students 34\u0000students shows highest upper cross syndrome and students with upper cross syndrome were having mean pain score of NPRS 4.52±2.18 and\u0000disability as per NDI & SPADI as 50.79 &51.28.overall prevalence of musculoskeletal dysfunction is 55.66%. Majority of the Conclusions:\u0000School going students are exposed to the risk of adopting poor postures which can lead to musculoskeletal dysfunction. The results of this study\u0000suggesting the importance of postural awareness among school going students.","PeriodicalId":14358,"journal":{"name":"International journal of scientific research","volume":"65 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141135935","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Culture sensitivity of deep tracheal suction samples collected from intubated patients has paramount importance in getting a proper antibiogram which can prevent morbidity and mortality and reduce the duration of ICU stay of the patients. Objectives are to nd out the bacteriological prole of isolates from deep tracheal suction samples at zero hours and at 48 hours of intubation, along with their antibiotic sensitivity pattern. 51 participants whose samples showed no growth at zero hours of intubation were included. Among the remaining 51 samples, 36 were found culture positive at 48 hours of intubation, where male participants were the majority with >60 years age group being maximally affected. Samples were collected in ICU, sent immediately to the microbiology laboratory followed by direct gram staining, and after plating, incubation, motility test and various biochemical identication methods, ABST was performed. Incidence of causative bacteria revealed gram negative bacilli to be more than gram positive organisms. Klebsiella pneumoniae showed maximum sensitivity to amikacin with other drugs being partially sensitive. Acinetobacter baumannii complex showed maximum sensitivity to levooxacin and amikacin, while being completely resistant to all other drugs. Amikacin and piperacillin tazobactam served the best combination therapy against Pseudomonas aeruginosa, while MRSA showed maximum sensitivity to linezolid. Antibiogram is thus an important tool in choosing selected antibiotics in order to prevent emergence of bacterial resistance in ventilator patients.
{"title":"BACTERIOLOGICAL PROFILE AND ANTIBIOGRAM OF AEROBIC BACTERIA ISOLATED FROM PATIENTS WITH VENTILATOR ASSOCIATED PNEUMONIA ADMITTED IN CRITICAL CARE UNIT OF A MEDICAL COLLEGE IN WEST BENGAL","authors":"Aritra Bhattacharya","doi":"10.36106/ijsr/0208326","DOIUrl":"https://doi.org/10.36106/ijsr/0208326","url":null,"abstract":"Culture sensitivity of deep tracheal suction samples collected from intubated patients has paramount importance in getting a proper antibiogram\u0000which can prevent morbidity and mortality and reduce the duration of ICU stay of the patients. Objectives are to nd out the bacteriological prole\u0000of isolates from deep tracheal suction samples at zero hours and at 48 hours of intubation, along with their antibiotic sensitivity pattern. 51\u0000participants whose samples showed no growth at zero hours of intubation were included. Among the remaining 51 samples, 36 were found culture\u0000positive at 48 hours of intubation, where male participants were the majority with >60 years age group being maximally affected. Samples were\u0000collected in ICU, sent immediately to the microbiology laboratory followed by direct gram staining, and after plating, incubation, motility test and\u0000various biochemical identication methods, ABST was performed. Incidence of causative bacteria revealed gram negative bacilli to be more than\u0000gram positive organisms. Klebsiella pneumoniae showed maximum sensitivity to amikacin with other drugs being partially sensitive.\u0000Acinetobacter baumannii complex showed maximum sensitivity to levooxacin and amikacin, while being completely resistant to all other drugs.\u0000Amikacin and piperacillin tazobactam served the best combination therapy against Pseudomonas aeruginosa, while MRSA showed maximum\u0000sensitivity to linezolid. Antibiogram is thus an important tool in choosing selected antibiotics in order to prevent emergence of bacterial resistance\u0000in ventilator patients.","PeriodicalId":14358,"journal":{"name":"International journal of scientific research","volume":"358 21","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141138498","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Objective: The aim of this 12-week, blind randomized control comparative study was to determine the safety and efcacy of uvoxamine and clomipramine in adult outpatients with obsessive-compulsive disorder (OCD). Method: 156 adult outpatients with DSM-IV OCD were randomly assigned into two groups to receive 100 to 300 mg of uvoxamine CR (N=78) or Clomipramine (N = 78) once daily at bedtime for 12 weeks. Intentto-treat, analysis of efcacy assessments with the Yale- Brown Obsessive Compulsive Scale (YBOCS), Clinical Global Impressions-Severity of Illness scale (CGI-S) was done. Results: The percentage of responders (response >35% improvement in the YBOCS total score) at the end of the study was similar in both groups (62% FLV vs 65% CMI) by LOCF analysis. Fluvoxamine CR and Clomipramine showed a signicant (>35%) decrease in YBOCS total score beginning at week 2. This early response was sustained at all subsequent visits. At endpoint, there was a mean decrease of 11.65 ± 0.7 (44.89%) in the YBOCS total score compared with baseline in the uvoxamine CR treatment group versus a mean decrease of 12.3 ± 0.7 (46.32%) in the clomipramine treatment group (p = .001). It was observed that FLV was better tolerated than CMI among subjects; patients treated with CMI had more anticholinergic side effects (dry mouth, constipation, and tremor) and premature withdrawals due to adverse events. CGI-S scores also showed a statistically signicant improvement of 59.25% in FLV group and 55.14% in CMI group. Conclusion: The study show that both uvoxamine and clomipramine has equivalent efcacy, wherein both the drugs start showing signicant reduction in primary efcacy parameters: YBOCS and CSI-S scores since the end of second week. Treatment dropout rate was higher in the Clomipramine (24%) group than the uvoxamine (17%) group. We concluded that with long-term or even life- long treatment appearing necessary for people with OCD, Fluvoxamine would appear to be the treatment of choice in view of their tolerability and safety advantages compared with clomipramine.
{"title":"FLUVOXAMINE VERSUS CLOMIPRAMINE FOR OBSESSIVE COMPULSIVE DISORDER: A COMPARATIVE STUDY TO DETERMINE SAFETY AND EFFICACY OF THE DRUGS","authors":"Anirudh Atul Salunke","doi":"10.36106/ijsr/9606856","DOIUrl":"https://doi.org/10.36106/ijsr/9606856","url":null,"abstract":"Objective: The aim of this 12-week, blind randomized control comparative study was to determine the safety and efcacy of uvoxamine and\u0000clomipramine in adult outpatients with obsessive-compulsive disorder (OCD). Method: 156 adult outpatients with DSM-IV OCD were randomly\u0000assigned into two groups to receive 100 to 300 mg of uvoxamine CR (N=78) or Clomipramine (N = 78) once daily at bedtime for 12 weeks. Intentto-treat, analysis of efcacy assessments with the Yale- Brown Obsessive Compulsive Scale (YBOCS), Clinical Global Impressions-Severity of\u0000Illness scale (CGI-S) was done. Results: The percentage of responders (response >35% improvement in the YBOCS total score) at the end of the\u0000study was similar in both groups (62% FLV vs 65% CMI) by LOCF analysis. Fluvoxamine CR and Clomipramine showed a signicant (>35%)\u0000decrease in YBOCS total score beginning at week 2. This early response was sustained at all subsequent visits. At endpoint, there was a mean\u0000decrease of 11.65 ± 0.7 (44.89%) in the YBOCS total score compared with baseline in the uvoxamine CR treatment group versus a mean decrease\u0000of 12.3 ± 0.7 (46.32%) in the clomipramine treatment group (p = .001). It was observed that FLV was better tolerated than CMI among subjects;\u0000patients treated with CMI had more anticholinergic side effects (dry mouth, constipation, and tremor) and premature withdrawals due to adverse\u0000events. CGI-S scores also showed a statistically signicant improvement of 59.25% in FLV group and 55.14% in CMI group. Conclusion: The\u0000study show that both uvoxamine and clomipramine has equivalent efcacy, wherein both the drugs start showing signicant reduction in primary\u0000efcacy parameters: YBOCS and CSI-S scores since the end of second week. Treatment dropout rate was higher in the Clomipramine (24%) group\u0000than the uvoxamine (17%) group. We concluded that with long-term or even life- long treatment appearing necessary for people with OCD,\u0000Fluvoxamine would appear to be the treatment of choice in view of their tolerability and safety advantages compared with clomipramine.","PeriodicalId":14358,"journal":{"name":"International journal of scientific research","volume":"46 11","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141141950","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Introduction: Free tissue transfer is warranted when local aps cannot be harvested outside the zone of injury or when soft tissue defects are extensive and are complicated by exposure of bone, tendon, vessel, nerves or implants. The free anterolateral thigh ap is one such option. It is a fasciocutaneous (FC) ap based on the septocutaneous or musculocutaneous perforators of the descending branch of the lateral circumex femoral artery. : This prospective study was conducted from June 2021 to December 2022. A total of 10 patien Materials And Methods ts were included in the study : Out of 10 patients, 6 were females and 4 were males. The maximum patients were in the age Results group of 41-60 years. Maximum patients had malignancy as the etiological factor. The ap was used for lower extremity defect reconstruction in 5 patients while for the rest it was done for upper extremity, scalp and abdominal defect reconstruction. The maximum length of the ap taken was 22cm and the maximum width taken was 18cm. The average pedicle length was 11cm. All required STSG coverage for closure of donor site. The mean duration of ap harvest was 2hrs 10min and the mean duration of surgery was 6hrs 52min. Flap congestion was seen in 3 patients which required re-exploration. Out of these, 2 aps had complete necrosis. The free anterolateral thigh ap is a workhorse ap for reconstruction of Conclusion: large complex defects. It is easy to harvest with relatively constant anatomy, offers long and large pedicle, and has minimal donor site morbidity.
{"title":"A STUDY ON THE VERSATILITY AND OUTCOME OF FREE ANTEROLATERAL THIGH FLAP FOR COVERAGE OF LARGE COMPLEX DEFECTS.","authors":"Kinkar Munian, Parvez Asfiah, Vinay N Baretha","doi":"10.36106/ijsr/2504813","DOIUrl":"https://doi.org/10.36106/ijsr/2504813","url":null,"abstract":"Introduction: Free tissue transfer is warranted when local aps cannot be harvested outside the zone of injury or when soft tissue defects are\u0000extensive and are complicated by exposure of bone, tendon, vessel, nerves or implants. The free anterolateral thigh ap is one such option. It is a\u0000fasciocutaneous (FC) ap based on the septocutaneous or musculocutaneous perforators of the descending branch of the lateral circumex femoral\u0000artery. : This prospective study was conducted from June 2021 to December 2022. A total of 10 patien Materials And Methods ts were included in\u0000the study : Out of 10 patients, 6 were females and 4 were males. The maximum patients were in the age Results group of 41-60 years. Maximum\u0000patients had malignancy as the etiological factor. The ap was used for lower extremity defect reconstruction in 5 patients while for the rest it was\u0000done for upper extremity, scalp and abdominal defect reconstruction. The maximum length of the ap taken was 22cm and the maximum width\u0000taken was 18cm. The average pedicle length was 11cm. All required STSG coverage for closure of donor site. The mean duration of ap harvest was\u00002hrs 10min and the mean duration of surgery was 6hrs 52min. Flap congestion was seen in 3 patients which required re-exploration. Out of these, 2\u0000aps had complete necrosis. The free anterolateral thigh ap is a workhorse ap for reconstruction of Conclusion: large complex defects. It is easy\u0000to harvest with relatively constant anatomy, offers long and large pedicle, and has minimal donor site morbidity.","PeriodicalId":14358,"journal":{"name":"International journal of scientific research","volume":"342 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141028091","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Background & Aim: Botulinum Toxin A is the most potent serotype, involved in the management of facial rejuvenation. The safety and effectiveness of Botulinum Toxin Type-A was evaluated for managing moderate to severe facial wrinkles in real-world clinical practice. Materials and Methods: Male and female subjects with moderate to severe facial wrinkles were included. Treatment was administered to single or multiple facial zones, depending on the case. The primary objective was to assess the safety and tolerability of the formulation used. The secondary objectives were to assess the effectiveness of the treatment based on the Investigator and subject-assessed Modied Global Aesthetic Improvement Scale (GAIS). The study involved 100 participants, mostly females (64%), with a mean (±S.D.) age of Results: 40.7±6.2 years. Eight of them reported a total of 10 adverse events (AEs), such as headache (3%) and heaviness of forehead (2%), but none reported serious adverse events (SAEs). The study revealed statistically signicant improvements, as assessed by the investigator and the subjects, in zones 1, 2, and 3 of the GAIS (Global Aesthetic Improvement Scale). Moreover, the percentage of subjects reporting "I look younger" increased from 3% in visit 1 to 70.7% in visit 4, signicantly. Botulinum toxin A appears to be well-tolerated and effective treatment opti Conclusion: on that enhances facial appearance and quality of life. It was associated with very few to no treatment-associated adverse events (TEAEs) and serious adverse events (SAEs).
{"title":"SAFETY AND EFFICACY OF BOTULINUM TOXIN TYPE A IN THE MANAGEMENT OF MODERATE TO SEVERE FACIAL WRINKLES","authors":"Adarsh Shetty","doi":"10.36106/ijsr/9104194","DOIUrl":"https://doi.org/10.36106/ijsr/9104194","url":null,"abstract":"Background & Aim: Botulinum Toxin A is the most potent serotype, involved in the management of facial rejuvenation. The safety and\u0000effectiveness of Botulinum Toxin Type-A was evaluated for managing moderate to severe facial wrinkles in real-world clinical practice. Materials\u0000and Methods: Male and female subjects with moderate to severe facial wrinkles were included. Treatment was administered to single or multiple\u0000facial zones, depending on the case. The primary objective was to assess the safety and tolerability of the formulation used. The secondary\u0000objectives were to assess the effectiveness of the treatment based on the Investigator and subject-assessed Modied Global Aesthetic Improvement\u0000Scale (GAIS). The study involved 100 participants, mostly females (64%), with a mean (±S.D.) age of Results: 40.7±6.2 years. Eight of them\u0000reported a total of 10 adverse events (AEs), such as headache (3%) and heaviness of forehead (2%), but none reported serious adverse events\u0000(SAEs). The study revealed statistically signicant improvements, as assessed by the investigator and the subjects, in zones 1, 2, and 3 of the GAIS\u0000(Global Aesthetic Improvement Scale). Moreover, the percentage of subjects reporting \"I look younger\" increased from 3% in visit 1 to 70.7% in\u0000visit 4, signicantly. Botulinum toxin A appears to be well-tolerated and effective treatment opti Conclusion: on that enhances facial appearance\u0000and quality of life. It was associated with very few to no treatment-associated adverse events (TEAEs) and serious adverse events (SAEs).","PeriodicalId":14358,"journal":{"name":"International journal of scientific research","volume":"6 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141025528","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Fabella is sesamoid type of bone found around the knee joint. Whenever fabella is present, it is embedded in proximal tendon of lateral head of gastrocnemius. Fabella helps to stabilize the postero-lateral aspect of knee joint, to diminish friction between bone and tendon, to alter the direction of pull and action of muscle. In the present case, during routine dissection for students on a male cadaver, it has been found that fabella was present in proximal tendon of medial head of gastrocnemius in left lower limb. Fabella is more commonly seen in Asian population (30-52%). Recently the knee joint is one of the most frequently injured and diseased joints, it has been the subject of extensive research. Pathologies related to fabella are fabella pain syndrome, common bular nerve palsy, and osteoarthritis. In order to diagnose and treat patients with pathology of this region, a deeper comprehension of the anatomy of the knee joint and its variations, such as fabella, is essential.
{"title":"FABELLA IN THE MEDIAL HEAD OF GASTROCNEMIUS -A CASE REPORT.","authors":"Ketav Daslania, Divya Parmar, Sucheta Chaudhary","doi":"10.36106/ijsr/4103091","DOIUrl":"https://doi.org/10.36106/ijsr/4103091","url":null,"abstract":"Fabella is sesamoid type of bone found around the knee joint. Whenever fabella is present, it is embedded in proximal tendon of lateral head of\u0000gastrocnemius. Fabella helps to stabilize the postero-lateral aspect of knee joint, to diminish friction between bone and tendon, to alter the direction\u0000of pull and action of muscle. In the present case, during routine dissection for students on a male cadaver, it has been found that fabella was present\u0000in proximal tendon of medial head of gastrocnemius in left lower limb. Fabella is more commonly seen in Asian population (30-52%). Recently the\u0000knee joint is one of the most frequently injured and diseased joints, it has been the subject of extensive research. Pathologies related to fabella are\u0000fabella pain syndrome, common bular nerve palsy, and osteoarthritis. In order to diagnose and treat patients with pathology of this region, a deeper\u0000comprehension of the anatomy of the knee joint and its variations, such as fabella, is essential.","PeriodicalId":14358,"journal":{"name":"International journal of scientific research","volume":"37 23","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141043517","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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