Cervical cancer which attacks the cervix is triggered by a virus called human papilloma virus (HPV). One effective treatment method for cervical cancer is external radiotherapy using a Linear Accelerator (Linac). This research aims to obtain radiation dose distribution by comparing the effectiveness of two treatment techniques cervical cancer, through Conformity Index (CI), Homogenity Index (HI), and radiation protection against Organ at Risk (OAR) in accordance with QUANTEC rules. The techniques used is Three Dimensional Conformal Radiation Therapy (3DCRT) with 2 directions of irradiation (anterior – posterior) and 4 directions of irradiation (box). Research data was obtained from 15 images of cervical cancer patients who have contoured by a Radiation Onkology Doctor at Indriati Hospital Solo Baru. From the result of the research, it can be said that the 3DCRT technique with 4 directions It can be seen from a higher Conformity Index (CI) value indicating a better level of conformity, and a lower Homogenity Index (HI) value indicating a higher level of homogenity. In addition, the 3DCRT technique with 4 directions of irradiation is also considered more effective in protecting OAR compared to 2 directions of irradiation.
{"title":"Dose Distribution Three-Dimensional Conformal Radiation Therapy (3DCRT) With 2 And 4 Directions in Treatment Planning System for Cervical Cancer Cases","authors":"Armayta Krisnanjani, Wahyu Setia Budi, Evi Setiawati, Septi Purwaningsih, Irma Juwita, Fasicha Furaida","doi":"10.32628/ijsrst2411352","DOIUrl":"https://doi.org/10.32628/ijsrst2411352","url":null,"abstract":"Cervical cancer which attacks the cervix is triggered by a virus called human papilloma virus (HPV). One effective treatment method for cervical cancer is external radiotherapy using a Linear Accelerator (Linac). This research aims to obtain radiation dose distribution by comparing the effectiveness of two treatment techniques cervical cancer, through Conformity Index (CI), Homogenity Index (HI), and radiation protection against Organ at Risk (OAR) in accordance with QUANTEC rules. The techniques used is Three Dimensional Conformal Radiation Therapy (3DCRT) with 2 directions of irradiation (anterior – posterior) and 4 directions of irradiation (box). Research data was obtained from 15 images of cervical cancer patients who have contoured by a Radiation Onkology Doctor at Indriati Hospital Solo Baru. From the result of the research, it can be said that the 3DCRT technique with 4 directions It can be seen from a higher Conformity Index (CI) value indicating a better level of conformity, and a lower Homogenity Index (HI) value indicating a higher level of homogenity. In addition, the 3DCRT technique with 4 directions of irradiation is also considered more effective in protecting OAR compared to 2 directions of irradiation.","PeriodicalId":14387,"journal":{"name":"International Journal of Scientific Research in Science and Technology","volume":" 755","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141669368","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Akankshsa S. Atole, Payal S. Badhe, Vijaya U. Barge
Hyperthyroidism is a condition characterized by increased in synthesis and secretion of thyroid hormones from thyroid gland. Methimazole is an anti-hyperthyroidism drug. It is of great importance and significance for life science. Up to now, various different methods have been applied for the determination of methimazole, such as spectrophotometry1-3, LC4, HPLC6, RP-HPLC7, HPLC-UV8, electrochemical analysis9, kinetic method10. In this paper, a new UV-Spectrophotometric method for the determination of methimazole has been established. The chemical name of Methimazole is (1-methylimidazole-2-thiol). The chemical formula of Methimazole is C4H6N2S and the molecular weight is 114.17 g/mol. The structure of Methimazole features a 5 membered imidazole ring with a methyl group at position 1st and thione group at position 2nd. Methimazole is white colour powder and has melting point 1440 C.
{"title":"A Review On : To Develop and Validate Analytical Method for Determination of Methimazole in Bulk and Pharmaceutical Dosage Form","authors":"Akankshsa S. Atole, Payal S. Badhe, Vijaya U. Barge","doi":"10.32628/ijsrst24113248","DOIUrl":"https://doi.org/10.32628/ijsrst24113248","url":null,"abstract":"Hyperthyroidism is a condition characterized by increased in synthesis and secretion of thyroid hormones from thyroid gland. Methimazole is an anti-hyperthyroidism drug. It is of great importance and significance for life science. Up to now, various different methods have been applied for the determination of methimazole, such as spectrophotometry1-3, LC4, HPLC6, RP-HPLC7, HPLC-UV8, electrochemical analysis9, kinetic method10. In this paper, a new UV-Spectrophotometric method for the determination of methimazole has been established. The chemical name of Methimazole is (1-methylimidazole-2-thiol). The chemical formula of Methimazole is C4H6N2S and the molecular weight is 114.17 g/mol. The structure of Methimazole features a 5 membered imidazole ring with a methyl group at position 1st and thione group at position 2nd. Methimazole is white colour powder and has melting point 1440 C.","PeriodicalId":14387,"journal":{"name":"International Journal of Scientific Research in Science and Technology","volume":" 17","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141677389","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Protein from the coronavirus causing severe acute respiratory syndrome (SARS-CoV) is responsible for binding to and identifying amino acid residues that are important for the synthesis of S1 with ACE2. It aids in the creation of antiviral inhibitors and experimental research. Anatomical models of the SARS-CoV S1 protein in fuse with human ACE2 were created in this study. One riboswitch depict for one strain of SARS Virus and five inhibitors have been classified for this riboswitch by virtual screening. These inhibitors seen to be free from the side effects of anti-viral agents.
{"title":"In-Silico Riboswitch Based Drug Design for SARS 1","authors":"Sonal Nivsarkar, Vishal Bhojyawal","doi":"10.32628/ijsrst24114102","DOIUrl":"https://doi.org/10.32628/ijsrst24114102","url":null,"abstract":"Protein from the coronavirus causing severe acute respiratory syndrome (SARS-CoV) is responsible for binding to and identifying amino acid residues that are important for the synthesis of S1 with ACE2. It aids in the creation of antiviral inhibitors and experimental research. Anatomical models of the SARS-CoV S1 protein in fuse with human ACE2 were created in this study. One riboswitch depict for one strain of SARS Virus and five inhibitors have been classified for this riboswitch by virtual screening. These inhibitors seen to be free from the side effects of anti-viral agents.","PeriodicalId":14387,"journal":{"name":"International Journal of Scientific Research in Science and Technology","volume":" 4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141676657","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Sadashiv N. Sinkar, Ram. B. Kohire, Dnyaneshwar T. Nagre
A Green and efficient environmentally synthesis using scientific microwave method of novel ligand derived from 2-amino 5-methyl benzimidazole with 2-bromo Isophthalaldehyde. Metal complexes were derived from Mn(II) chloride and nitrate of Co(II), Ni(II), Cu(II), Zn(II), Cd(II), salts with novel ligand at the end of the reaction all metal complexes show fine colour. By TLC and melting point of each complex was confirming the formation of metal complex. Characterization of novel ligand carried out by elemental analysis, IR,1HNMR, Mass spectroscopy and characterization of metal complexes carried out by UV, IR. The thermal stability of Zn (II) and Cd (II) complexes was studied by thermo-gravimetric analyses (TGA). All metal complexes show antibacterial activity against E-Coli, S.Aureus and S.Typhi.
{"title":"Green and Efficient Synthesis, Spectroscopic, Characterization, Antibacterial Activity of Some Selected Transition Metal Complexes of Novel Schiff Base Ligand Derived from 2-amino 5-methyl benzimidazole with 2-bromo Isophthalaldehyde","authors":"Sadashiv N. Sinkar, Ram. B. Kohire, Dnyaneshwar T. Nagre","doi":"10.32628/ijsrst24114101","DOIUrl":"https://doi.org/10.32628/ijsrst24114101","url":null,"abstract":"A Green and efficient environmentally synthesis using scientific microwave method of novel ligand derived from 2-amino 5-methyl benzimidazole with 2-bromo Isophthalaldehyde. Metal complexes were derived from Mn(II) chloride and nitrate of Co(II), Ni(II), Cu(II), Zn(II), Cd(II), salts with novel ligand at the end of the reaction all metal complexes show fine colour. By TLC and melting point of each complex was confirming the formation of metal complex. Characterization of novel ligand carried out by elemental analysis, IR,1HNMR, Mass spectroscopy and characterization of metal complexes carried out by UV, IR. The thermal stability of Zn (II) and Cd (II) complexes was studied by thermo-gravimetric analyses (TGA). All metal complexes show antibacterial activity against E-Coli, S.Aureus and S.Typhi.","PeriodicalId":14387,"journal":{"name":"International Journal of Scientific Research in Science and Technology","volume":" 42","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141673840","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Dr. Pamarthi Nagarjuna, Dr. N Madhusudan Babu, Dr. K Sudheer
INTRODUCTION - Pleural effusion is the abnormal collection of fluid in the pleural space. It is classified into exudates and transudates based on Light's criteria. Among the extra pulmonary presentations after tuberculous lymphadenitis, pleural TB is the second frequent. Although many biochemical parameters, such as lactate dehydrogenase (LDH), C-reactive protein (CRP), adenosine deaminase (ADA), interferon-gamma, and procalcitonin levels have been studied in the context of the diagnosis of exudative pleural effusion, its diagnosis is still challenging. AIMS & OBJECTIVES- To determine whether the combined use of ADA activity and lymphocyte/neutrophil ratio would provide a more efficient means for diagnosing tuberculous pleural effusion than the use of ADA alone. MATERIAL & METHODS- Hospital based Observational study was conducted over 8 months with total number of 100 Patients diagnosed as having pleural effusion based on clinical features and chest radiography in GEMS MEDICAL COLLEGE AND HOSPITAL. Biochemical, cytological and microbiology studies were done by obtaining pleural fluid by thoracocentesis. RESULTS - out of 100 cases, 84 cases were tubercular and had high level of ADA in comparison to rest of 16 non tubercular cases. At level of 50 IU/L of ADA activity test had sensitivity of 97.6%, specificity 87.5% which was increased to 100% and 92.8% in combination with test of Lymphocytic/Neutrophilic ratio - 0.75 CONCLUSION- The combined use of ADA along with the L/N ratio would provide a more efficient means for diagnosing tuberculous pleural effusion than the use of ADA alone.
简介--胸腔积液是指胸膜腔内液体的异常聚集。根据莱特的标准，胸腔积液可分为渗出液和透出液。在继结核性淋巴结炎之后的肺外表现中，胸腔结核是第二常见的疾病。尽管许多生化指标，如乳酸脱氢酶（LDH）、C反应蛋白（CRP）、腺苷脱氨酶（ADA）、γ干扰素和降钙素原水平，都已被用于渗出性胸腔积液的诊断，但其诊断仍具有挑战性。目的和目标：确定联合使用 ADA 活性和淋巴细胞/中性粒细胞比值是否比单独使用 ADA 更能有效诊断结核性胸腔积液。材料和方法- 在 GEMS 医学院和医院进行了为期 8 个月的观察性研究，共有 100 名患者根据临床特征和胸部放射线检查被诊断为胸腔积液。通过胸腔穿刺获取胸腔积液，进行生化、细胞学和微生物学研究。结果 - 在 100 例病例中，84 例为结核病患者，与其余 16 例非结核病患者相比，他们的 ADA 水平较高。当 ADA 活性水平为 50 IU/L 时，检测灵敏度为 97.6%，特异性为 87.5%，而结合淋巴细胞/中性粒细胞比值 - 0.75 的检测，灵敏度提高到 100%，特异性提高到 92.8%。
{"title":"To Study the Combined Use of Pleural Fluid Lymphocyte / Neutrophil Ratio and ADA for the Diagnosis of Tuberculous Pleural Effusion","authors":"Dr. Pamarthi Nagarjuna, Dr. N Madhusudan Babu, Dr. K Sudheer","doi":"10.32628/ijsrst2411348","DOIUrl":"https://doi.org/10.32628/ijsrst2411348","url":null,"abstract":"INTRODUCTION - Pleural effusion is the abnormal collection of fluid in the pleural space. It is classified into exudates and transudates based on Light's criteria. Among the extra pulmonary presentations after tuberculous lymphadenitis, pleural TB is the second frequent. Although many biochemical parameters, such as lactate dehydrogenase (LDH), C-reactive protein (CRP), adenosine deaminase (ADA), interferon-gamma, and procalcitonin levels have been studied in the context of the diagnosis of exudative pleural effusion, its diagnosis is still challenging. \u0000AIMS & OBJECTIVES- To determine whether the combined use of ADA activity and lymphocyte/neutrophil ratio would provide a more efficient means for diagnosing tuberculous pleural effusion than the use of ADA alone. \u0000MATERIAL & METHODS- Hospital based Observational study was conducted over 8 months with total number of 100 Patients diagnosed as having pleural effusion based on clinical features and chest radiography in GEMS MEDICAL COLLEGE AND HOSPITAL. Biochemical, cytological and microbiology studies were done by obtaining pleural fluid by thoracocentesis. \u0000RESULTS - out of 100 cases, 84 cases were tubercular and had high level of ADA in comparison to rest of 16 non tubercular cases. At level of 50 IU/L of ADA activity test had sensitivity of 97.6%, specificity 87.5% which was increased to 100% and 92.8% in combination with test of Lymphocytic/Neutrophilic ratio - 0.75 \u0000CONCLUSION- The combined use of ADA along with the L/N ratio would provide a more efficient means for diagnosing tuberculous pleural effusion than the use of ADA alone.","PeriodicalId":14387,"journal":{"name":"International Journal of Scientific Research in Science and Technology","volume":"74 7","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141688387","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
This research investigates the impact of ink sequences and paper substrates on color reproduction in offset printing. Through experimentation and analysis, we demonstrate how altering the sequence of ink application influences color gamut. The variations in color gamut depend on the ink transfer capabilities. The MYCK order allows the most extensive color gamut for the investigated conditions. However, the effect is less observed on uncoated paper due to its high absorbency, resulting in minimal changes in ink transfer processes. Furthermore, our study highlights a substantial difference in color gamut between coated and uncoated paper, emphasizing the importance of considering paper substrate for achieving desired color reproduction. This research provides valuable insights for optimizing color fidelity in offset printing processes.
{"title":"Ink Sequence Effects on Color Gamut in Multicolor Lithographic Printing","authors":"Hoang Thi Kieu Nguyen","doi":"10.32628/ijsrst2411334","DOIUrl":"https://doi.org/10.32628/ijsrst2411334","url":null,"abstract":"This research investigates the impact of ink sequences and paper substrates on color reproduction in offset printing. Through experimentation and analysis, we demonstrate how altering the sequence of ink application influences color gamut. The variations in color gamut depend on the ink transfer capabilities. The MYCK order allows the most extensive color gamut for the investigated conditions. However, the effect is less observed on uncoated paper due to its high absorbency, resulting in minimal changes in ink transfer processes. Furthermore, our study highlights a substantial difference in color gamut between coated and uncoated paper, emphasizing the importance of considering paper substrate for achieving desired color reproduction. This research provides valuable insights for optimizing color fidelity in offset printing processes.","PeriodicalId":14387,"journal":{"name":"International Journal of Scientific Research in Science and Technology","volume":"99 16","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-06-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141352218","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
This paper explores the multifaceted aspects of improving academic performance through detailed data analysis, diverse teaching methods, student engagement, and parental involvement. By examining the impact of traditional and innovative teaching strategies, the study highlights the benefits of combining structured and interactive approaches to enhance learning. The crucial role of student engagement and parental support in boosting academic success is also discussed. Additionally, the paper delves into the transformative potential of data mining and machine learning in education, illustrating how these technologies can uncover valuable insights and predict student performance trends. This comprehensive approach aims to provide a robust framework for educators to optimize educational outcomes and foster a more effective learning environment.
{"title":"Educational Knowledge Discovery : A Quality Assurance Analysis of Academic Results Employing Data Mining","authors":"Avleen Kaur Mandeep Kaur, Dr. Pardeep Arora","doi":"10.32628/ijsrst24113235","DOIUrl":"https://doi.org/10.32628/ijsrst24113235","url":null,"abstract":"This paper explores the multifaceted aspects of improving academic performance through detailed data analysis, diverse teaching methods, student engagement, and parental involvement. By examining the impact of traditional and innovative teaching strategies, the study highlights the benefits of combining structured and interactive approaches to enhance learning. The crucial role of student engagement and parental support in boosting academic success is also discussed. Additionally, the paper delves into the transformative potential of data mining and machine learning in education, illustrating how these technologies can uncover valuable insights and predict student performance trends. This comprehensive approach aims to provide a robust framework for educators to optimize educational outcomes and foster a more effective learning environment.","PeriodicalId":14387,"journal":{"name":"International Journal of Scientific Research in Science and Technology","volume":"102 20","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141362546","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Garima, Abhinav Tripathi, G. R. Mishra, Sachin Singh
In the present study, a view to keep MOS devices such as CMOS technology appropriates to “Moore’s Law” several solutions have been proposed. Despite those proposals, these solutions also face quite a few restrictions and constriction. This has boosted the research to discover alternative technologies, to design circuits at great nanometer level. In future the conventional digital system and circuit can be designed through Quantum Dot Cellular Automata. High density as well as rate is superior matches for QCA. The QCA are in the place of the digital circuit in order by division of electrons. It is gorgeous for its dense dimension, quicker velocity, extremely scalable, advanced switching frequency, and small power use compared to CMOS skill. QCA are emergent skill that is measured as the improved practical exchange resolution for CMOS skill which suffers from short channel effect. QCA is a transistor less technology which has charge skill, and the data is spread and framed on the electrons charge and by columbic interaction hypothesis. QCA can get more than CMOS skill in future because of its major profit. This paper mostly projects the realization and simulation results of various logic gates as: Majority Voter gate, Basic gate, Universal gate, Exclusive gate & Full Adder through QCA. All utilities and presentation of the schemes can be displayed through QCA Designer 2.0.
{"title":"Efficiency Optimization of One-Bit Full Adder through Quantum Dot Cellular Automata","authors":"Garima, Abhinav Tripathi, G. R. Mishra, Sachin Singh","doi":"10.32628/ijsrst24113130","DOIUrl":"https://doi.org/10.32628/ijsrst24113130","url":null,"abstract":"In the present study, a view to keep MOS devices such as CMOS technology appropriates to “Moore’s Law” several solutions have been proposed. Despite those proposals, these solutions also face quite a few restrictions and constriction. This has boosted the research to discover alternative technologies, to design circuits at great nanometer level. In future the conventional digital system and circuit can be designed through Quantum Dot Cellular Automata. High density as well as rate is superior matches for QCA. The QCA are in the place of the digital circuit in order by division of electrons. It is gorgeous for its dense dimension, quicker velocity, extremely scalable, advanced switching frequency, and small power use compared to CMOS skill. QCA are emergent skill that is measured as the improved practical exchange resolution for CMOS skill which suffers from short channel effect. QCA is a transistor less technology which has charge skill, and the data is spread and framed on the electrons charge and by columbic interaction hypothesis. QCA can get more than CMOS skill in future because of its major profit. This paper mostly projects the realization and simulation results of various logic gates as: Majority Voter gate, Basic gate, Universal gate, Exclusive gate & Full Adder through QCA. All utilities and presentation of the schemes can be displayed through QCA Designer 2.0.","PeriodicalId":14387,"journal":{"name":"International Journal of Scientific Research in Science and Technology","volume":" 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-06-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141368855","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Nitin M. Ghatbandhe, Dr. Priya A. Sangole, Nitesh D. Punyaprediwar, Dr. Rakhi shambharkar, Dr. Ashish K. Kavale, Dr. Ganesh D. Satpute
Inclusion Complex is supramolecular system which is formed by inclusion of the guest molecules into the cavity of host molecule and these molecules are held by intermolecular forces but not by covalent bond. The special characteristic of Cyclodextrins is the ability to form an inclusion complex with viable compounds. This article focuses on the various preparation methods for inclusion complexes, their formation constant, experimental and spectral approaches to demonstrate host-guest interaction. Phase solubility diagram indicated that the solubility of guest molecule increases linearly with CD concentration in AL-type and a stoichiometry of 1:1. The inclusion complex formed by various techniques was characterized by various spectroscopic methods. The study offers a variety of studies that demonstrate how cyclodextrins can be used to enhance the solubility, stability, and effectiveness of synthetic pharmaceuticals as well as their physical, chemical, and biological properties.
包涵复合物是一种超分子体系，它是通过将客体分子包涵到宿主分子的空腔中而形成的，这些分子通过分子间作用力而不是共价键结合在一起。环糊精的特点是能够与有活力的化合物形成包合复合物。本文重点介绍了包涵复合物的各种制备方法、其形成常数、实验和光谱方法，以证明主客体之间的相互作用。相溶解度图显示，客体分子的溶解度随 AL 型中 CD 浓度的增加而线性增加，其化学计量为 1:1。通过各种光谱方法对各种技术形成的包合物进行了表征。这项研究提供了多种研究方法，展示了如何利用环糊精来提高合成药物的溶解度、稳定性和有效性，以及它们的物理、化学和生物特性。
{"title":"Methods of Preparation and Characterization of Cyclodextrin Encapsulated Inclusion Complex : Review","authors":"Nitin M. Ghatbandhe, Dr. Priya A. Sangole, Nitesh D. Punyaprediwar, Dr. Rakhi shambharkar, Dr. Ashish K. Kavale, Dr. Ganesh D. Satpute","doi":"10.32628/ijsrst24113129","DOIUrl":"https://doi.org/10.32628/ijsrst24113129","url":null,"abstract":"Inclusion Complex is supramolecular system which is formed by inclusion of the guest molecules into the cavity of host molecule and these molecules are held by intermolecular forces but not by covalent bond. The special characteristic of Cyclodextrins is the ability to form an inclusion complex with viable compounds. This article focuses on the various preparation methods for inclusion complexes, their formation constant, experimental and spectral approaches to demonstrate host-guest interaction. Phase solubility diagram indicated that the solubility of guest molecule increases linearly with CD concentration in AL-type and a stoichiometry of 1:1. The inclusion complex formed by various techniques was characterized by various spectroscopic methods. The study offers a variety of studies that demonstrate how cyclodextrins can be used to enhance the solubility, stability, and effectiveness of synthetic pharmaceuticals as well as their physical, chemical, and biological properties.","PeriodicalId":14387,"journal":{"name":"International Journal of Scientific Research in Science and Technology","volume":" 23","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-06-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141370029","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The chrysin quantitative from leaf samples were analysed using HPTLC. All the samples were active on TLC plate and revealed the presence of chrysin. The maximum amount of chrysin was obtained from in vivo leaf powder (0.60 μg) than in vitro leaf powder.
{"title":"Chrysin Quantification from Leaf Samples of Dolichandrone Falcata","authors":"R. P. Bansode, S. E. Mahamune","doi":"10.32628/ijsrst2411323","DOIUrl":"https://doi.org/10.32628/ijsrst2411323","url":null,"abstract":"The chrysin quantitative from leaf samples were analysed using HPTLC. All the samples were active on TLC plate and revealed the presence of chrysin. The maximum amount of chrysin was obtained from in vivo leaf powder (0.60 μg) than in vitro leaf powder.","PeriodicalId":14387,"journal":{"name":"International Journal of Scientific Research in Science and Technology","volume":" 8","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-06-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141369204","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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