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A Study on Serum Immunoglooubin E levels as a marker in childhood asthma 血清免疫球蛋白E水平作为儿童哮喘标志物的研究
Pub Date : 2020-07-01 DOI: 10.33545/26643685.2020.v3.i2c.109
S. Sr, R. R., Harivasudevan S, C. S.
Background: Asthma is a chronic inflammatory of the lungs which causes bronchial hyperresponsiveness and reversible airway obstruction. The disease predominantly affects the children. Bronchial asthma is manifested in response to external trigger of allergens. The most important risk factor is atopy, which produces high amount of IgE, the aim of this study is to evaluate serum IgE levels as a marker for the disease activity and study the correlation with the severity of bronchial asthma. Methods: A prospective study was conducted in peadiatrics department of the tertiary care hospital from March 2019 to February 2019. Children between 6-12yrs admitted with clinical features of asthma as per GINA guidelines was included in the study. IgE levels were taken at the time of the initial presentation. Results: The study showed that all the participants 100% who presented with clinical features suggestive of asthma had high IgE levels irrespective of age, sex and severity of asthma. The mean IgE levels in females were more than males. As the severity of asthma increased the mean IgE levels also increased. Conclusion: The study conclude that the IgE levels are independent of age and sex. IgE levels are directly proportional to severity of asthma.
背景:哮喘是肺部的一种慢性炎症,可引起支气管高反应性和可逆性气道阻塞。这种疾病主要影响儿童。支气管哮喘表现为对外界过敏原的反应。最重要的危险因素是特应性,它会产生大量的IgE,本研究的目的是评估血清IgE水平作为疾病活动性的标志,并研究其与支气管哮喘严重程度的相关性。方法:于2019年3月至2019年2月在该三级医院儿科进行前瞻性研究。根据GINA指南,6-12岁之间有哮喘临床特征的儿童被纳入研究。在初次就诊时测定IgE水平。结果:研究表明,所有表现出哮喘临床特征的参与者(100%),无论年龄、性别和哮喘严重程度,都有高IgE水平。女性的平均IgE水平高于男性。随着哮喘严重程度的增加,平均IgE水平也随之增加。结论:IgE水平与年龄、性别无关。IgE水平与哮喘的严重程度成正比。
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引用次数: 0
Geriatric depression in contemporary India: An overview 当代印度的老年抑郁症:综述
Pub Date : 2020-07-01 DOI: 10.33545/26643685.2020.v3.i2b.181
Khairkar Sushma Narayan, Dr. Mridula Saikia Khanikor
Introduction: The Indian elderly population is currently the second largest in the world. Depression is quite common among elderly living in the community in India. Depression in elderly is not yet perceived as a public health problem and is grossly underdiagnosed and undertreated. Methodology: Survey of secondary literature is the prime methodology for preparing this research article. Research Findings: There is a significant gap in research evaluating various aspects of depression in elderly in India. There is a need for multicentric, longitudinal studies evaluating various aspects of depression i n India’s geriatric population. Conclusion: Majority of depressive disorders remains undiagnosed and untreated because of a wrong belief that it is a part of ageing and a social stigma. There is a need to sensitize the primary care physicians and specialists from different specialties to identify and manage depression in India’s geriatric population.
印度的老年人口目前是世界上第二大的。抑郁症在印度社区的老年人中很常见。老年人抑郁症尚未被视为一个公共卫生问题,而且诊断和治疗严重不足。方法:二手文献调查是准备本研究文章的主要方法。研究发现:在评估印度老年人抑郁症的各个方面的研究存在显著差距。有必要进行多中心的纵向研究,评估印度老年人群中抑郁症的各个方面。结论:大多数抑郁症仍未得到诊断和治疗,因为人们错误地认为它是老龄化的一部分,是一种社会耻辱。有必要提高初级保健医生和来自不同专业的专家的敏感性,以识别和管理印度老年人口的抑郁症。
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引用次数: 0
Comparison of correlation of various methods of gestational age assessment in term neonates 足月新生儿不同胎龄评估方法的相关性比较
Pub Date : 2020-07-01 DOI: 10.33545/26643685.2020.v3.i2b.101
Mahesh Khanna Sa, Chandrasekar Balachandran, S. Chidambaranathan, R. P. Kumar
Knowledge of gestational age of newborn babies may modify the details of their care. Though gestational age is usually calculated from the date of mother’s last menstrual period this date is not known with certainty in large majority of pregnancy. In others there may be misleading information especially when the menstrual cycle is irregular, when conception is shortly after a previous pregnancy or when the mother was taking oral contraceptives shortly before conception. Hence the need of multiple modalities to confirm the gestational age and the reliability of modalities is a major concern. Our study is undertaken to compare the correlation of gestation age assessment by three methods viz., gestational age assessment by last menstrual period dates, gestational age assessment by last trimester ultrasound and gestational assessment by post-natal assessment of modified Ballard score. This study is a prospective study conducted in a rural medical college hospital. Total of 150 term babies were enrolled in the study. Duration of the study was two years. The gestational age of the neonates was calculated by all 3 methods and the correlation was assessed. The study concluded that the modified Ballard score overestimates the gestational age and the third trimester ultrasound underestimates the gestational age.
对新生儿胎龄的了解可能会改变他们护理的细节。虽然胎龄通常是从母亲最后一次月经的日期计算的,但在大多数怀孕中,这个日期是不确定的。在其他情况下,特别是当月经周期不规律,怀孕后不久怀孕或母亲在怀孕前不久服用口服避孕药时,可能会有误导性的信息。因此,需要多种模式来确认胎龄和模式的可靠性是一个主要问题。我们的研究是比较三种方法的胎龄评估的相关性,即最后一次月经日期胎龄评估、最后三个月超声胎龄评估和产后改良巴拉德评分胎龄评估。本研究是在一所农村医学院附属医院进行的前瞻性研究。共有150名足月婴儿参加了这项研究。研究时间为两年。采用3种方法计算新生儿胎龄并评价相关性。该研究得出结论,改良的巴拉德评分高估了胎龄,而孕晚期超声低估了胎龄。
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引用次数: 0
Biochemical profile of children with severe acute malnutrition 严重急性营养不良儿童的生化特征
Pub Date : 2020-07-01 DOI: 10.33545/26643685.2020.v3.i2c.110
Ashok E, Dr. S Ramesh, Dr. R Surya Prakash
Background: Malnutrition in children is widely prevalent in developing countries including India. More than 33% of the deaths in 0-5 years are associated with malnutrition. Children with severe acute malnutrition (SAM) are in danger of death from hypoglycemia, hypothermia, fluid overload, electrolyte imbalances. Hence, biochemical profile in these children is important for management. Objectives: The aim of this study is to describe the biochemical profile of children with severe acute malnutrition. Methods: This hospital based observational study was conducted on children with Severe Acute Malnutrition. Children were tested for biochemical parameters like complete blood counts with peripheral smear, C-Reactive protein, Blood glucose, renal function tests, serum electrolytes, calcium. Results: Among the study participants, 35 (46.7%) were anemic. CRP was Positive in 37, (49.3%) of the study population, Peripheral Smear showing Microcytic picture was present in 33, (44.0%) of the study population. Hypocalcaemia was present in 15, (20.0%), Hypokalaemia in 21, (28.0%) and Hyponatremia in 3, (4.0%). Elevated Urea was present in 34, (44.0%) and Elevated Creatinine in 30, (40.0%). Random Blood Sugar showed Hypoglycemia among 19, (25.3%). Conclusion: The observations in this study confirm a significant association between severe acute malnutrition and abnormalities in biochemical parameters. Many of these children had abnormal biochemical parameters like anemia, hypocalcemia, hypokalemia, hyponatremia, hypoglycaemia.
背景:儿童营养不良在包括印度在内的发展中国家普遍存在。0-5岁儿童死亡的33%以上与营养不良有关。患有严重急性营养不良(SAM)的儿童有因低血糖、低体温、体液超载、电解质失衡而死亡的危险。因此,这些儿童的生化特征对管理很重要。目的:本研究的目的是描述严重急性营养不良儿童的生化特征。方法:以医院为基础,对重症急性营养不良患儿进行观察性研究。对儿童进行生化指标检测,如外周血涂片全血细胞计数、c反应蛋白、血糖、肾功能检查、血清电解质、钙。结果:在研究参与者中,35人(46.7%)贫血。CRP阳性37例(49.3%),外周涂片显示小细胞图像33例(44.0%)。低钙血症15例(20.0%),低钾血症21例(28.0%),低钠血症3例(4.0%)。尿素升高34例(44.0%),肌酐升高30例(40.0%)。随机血糖显示低血糖者19例,占25.3%。结论:本研究结果证实了严重急性营养不良与生化指标异常之间的显著相关性。这些儿童中的许多人有异常的生化参数,如贫血,低钙血症,低钾血症,低钠血症,低血糖。
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引用次数: 0
Macrosomia index in neonates of diabetic mothers as a simple predictor of maternal glycemic control 糖尿病母亲新生儿巨大儿指数作为母亲血糖控制的简单预测指标
Pub Date : 2020-07-01 DOI: 10.33545/26643685.2020.v3.i2c.108
A. Durga, R. PraveenKumar, S. Chidambaranathan, Balachandran Cs
Background: About 2–5% of the pregnancies are complicated by diabetes and is recognized to be related with poor maternal and fetal outcomes. An abnormal Macrosomia index (MI) or Macrosomia index (HC in cm/CC in cm) of ≤1 can be considered as a marker for macrosomia in infants of diabetic mothers. The main objective of this study to correlate the maternal glycemic control with neonatal macrosomia index. This is a Cross sectional observational study done among the neonates of mothers with diabetes attending a Medical College Hospital. Birth weight, head circumference and chest circumference, MI, were measured. Glycated haemoglobin (HbA1C) were measured in mother at third trimester or at early puerperium. The results showed that there is a negative correlation of MI with HbA1C. So MI can be used as a predictor of maternal glycemic status and we also recommend strict glycemic control with regular monitoring of the HbA1C levels in antenatal mother and meticulous monitoring for the complications in neonates with abnormal MI (≤1).
背景:约2-5%的妊娠合并糖尿病,并被认为与不良的母胎结局有关。异常巨大儿指数(MI)或异常巨大儿指数(HC / cm/CC)≤1可视为糖尿病母亲所生婴儿存在巨大儿的标志。本研究的主要目的是探讨产妇血糖控制与新生儿巨大儿指数的关系。这是一项横断面观察研究,在一所医学院附属医院的糖尿病母亲所生的新生儿中进行。测量出生体重、头围和胸围。在妊娠晚期或产褥期早期测量母亲的糖化血红蛋白(HbA1C)。结果显示心肌梗死与HbA1C呈负相关。因此,心肌梗死可作为母亲血糖状态的预测指标,我们建议严格控制血糖,定期监测产前母亲的HbA1C水平,并对心肌梗死异常(≤1)的新生儿的并发症进行严密监测。
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引用次数: 0
Evaluation of the cord blood albumin for the early prediction of neonatal jaundice 脐带血白蛋白对新生儿黄疸早期预测的评价
Pub Date : 2020-01-01 DOI: 10.33545/26643685.2020.v3.i1b.63
Sannan Shaikh, Hasmukh Chauhan, Nairuti A Sanghavi
Background and Aim: Neonatal Hyperbilirubinemia (NH) is the most common cause for readmission during the early neonatal period. There are reports of bilirubin induced brain damage occurred in healthy term infants even without haemolysis and the sequalae could be serious. Aim of the study was to predict the development of Neonatal Hyperbilirubinemia at birth using Cord Serum Albumin as a risk indicator.Material and Methods: Observation study was performed on 348 healthy term new-borns. Cord blood was collected from the healthy term new-borns delivered either vaginally or caesarean section for cord serum albumin level measurements. Total serum bilirubin and direct serum bilirubin were measured during 72-96 hours of life with serum sampling of peripheral venous blood. Newburn was assessed clinically daily for Neonatal Hyperbilirubinemia or for any other complication during the study period. Results: Study cohort is grouped into Group1, Group2 and Group 3 based on Cord Serum Albumin level 2.8g/dl, 2.9-3.3g/dl and 3.4g/dl, respectively. In these groups, new-borns with total serum bilirubin level 17mg/dl after 72 hours are taken as Neonatal Hyperbilirubinemia, requiring interventions like phototherapy or exchange transfusion. Conclusion: There is a correlation between Cord serum albumin level and neonatal hyperbilirubinemia in healthy term new-borns. Cord serum albumin level of 2.8 g/dl can predict the development of neonatal hyperbilirubinemia.
背景与目的:新生儿高胆红素血症(NH)是新生儿早期再入院最常见的原因。有报道称,胆红素引起的脑损伤发生在健康足月婴儿,即使没有溶血,后遗症可能很严重。该研究的目的是预测新生儿高胆红素血症的发展,在出生时使用脐带血清白蛋白作为风险指标。材料与方法:对348例健康足月新生儿进行观察研究。采集顺产或剖宫产的健康足月新生儿脐带血,测定脐带血血清白蛋白水平。在72 ~ 96小时内测定血清总胆红素和直接血清胆红素,同时采集外周血静脉血。在研究期间,Newburn每天接受新生儿高胆红素血症或任何其他并发症的临床评估。结果:根据脐血白蛋白水平(2.8g/dl、2.9 ~ 3.3g/dl、3.4g/dl)将研究队列分为组1、组2、组3。在这些组中,72小时后血清总胆红素水平为17mg/dl的新生儿被视为新生儿高胆红素血症,需要光疗或换血等干预措施。结论:健康足月新生儿脐血白蛋白水平与新生儿高胆红素血症存在相关性。脐血白蛋白水平2.8 g/dl可预测新生儿高胆红素血症的发生。
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引用次数: 0
Case based vs project based teaching in Paediatrics: A cross sectional perception and result based study 儿科案例教学与项目教学:横断面感知与结果研究
Pub Date : 2020-01-01 DOI: 10.33545/26643685.2020.V3.I1B.133
Anant Pai
Paediatrics is a clinical subject, which is taught in IIIrd year of MBBS. According to current curriculum the subject is mainly taught in classroom setting and very less exposure to clinical application and hospital based real life situations. It makes subject very insipid and students do not understand the utilization of subject during their actual practice. Clinical application based learning involves clinical projects that incorporate complex tasks, based on challenging questions or problems that involve students in design, problem-solving, decision-making, or investigative activities; give students the opportunity to work relatively autonomously over extended periods of time; and culminate in realistic products or presentations. This study puts in an effort to find the superior of the two ways of clinical teaching. The first being the case based learning and the second being the project based learning.
儿科是一门临床学科,在MBBS的第三年教授。根据目前的课程设置,该学科主要在课堂教学,很少接触临床应用和基于医院的现实生活情况。这使得学科非常枯燥,学生在实际操作中不理解学科的运用。基于临床应用的学习包括临床项目,包括复杂的任务,基于具有挑战性的问题或涉及学生设计,解决问题,决策或调查活动的问题;让学生有机会在较长时间内相对自主地学习;并在现实的产品或演示中达到高潮。本研究旨在寻找两种临床教学方式的优势。第一种是基于案例的学习第二种是基于项目的学习。
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引用次数: 0
A comparative study on CRP and ESR in the diagnosis of pediatric septicemia: An institutional experience CRP与ESR在小儿败血症诊断中的比较研究:一项机构经验
Pub Date : 2020-01-01 DOI: 10.33545/26643685.2020.v3.i1c.202
Dr. N Ram Charana Reddy
Introduction: Sepsis is a life-threatening condition that occurs when the body's response to an infection damages its own tissues and organs. In children, sepsis is a leading cause of death. This study aimed to compare the diagnostic efficacy of C-Reactive Protein (CRP) and Erythrocyte Sedimentation Rate (ESR) in pediatric patients with suspected septicemia. Material and Methods: This retrospective study included 125 pediatric patients aged 0-12 years, comprising a sepsis group (n=75) and a control group (n=50). Demographic data, presenting symptoms, vital signs on presentation, and laboratory results, including CRP and ESR levels, were recorded and analyzed. Results: Mean CRP levels were significantly higher in the sepsis group than in the control group. Similarly, mean ESR was higher in the sepsis group. Both parameters correlated with the severity of symptoms and aberrant vital signs on presentation. Conclusion: Both CRP and ESR showed significant elevation in pediatric septicemia, with CRP appearing more accurate and reliable. Further large-scale, prospective studies are needed to validate these findings and establish standardized cut-off levels for these biomarkers in diagnosing pediatric sepsis.
败血症是一种危及生命的疾病,当身体对感染的反应损害了自身的组织和器官时,就会发生败血症。在儿童中,败血症是导致死亡的主要原因。本研究旨在比较c反应蛋白(CRP)和红细胞沉降率(ESR)对小儿疑似败血症的诊断效果。材料和方法:本回顾性研究纳入125例0-12岁的儿童患者,包括败血症组(n=75)和对照组(n=50)。记录和分析人口统计数据、出现症状、就诊时的生命体征和实验室结果,包括CRP和ESR水平。结果:脓毒症组CRP水平明显高于对照组。同样,脓毒症组的平均ESR更高。这两个参数与症状的严重程度和出现时的异常生命体征相关。结论:小儿败血症CRP和ESR均有显著升高,CRP更准确可靠。需要进一步的大规模前瞻性研究来验证这些发现,并建立诊断儿童败血症时这些生物标志物的标准化截止水平。
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引用次数: 0
Clinical profile and short-term outcome of pediatric status epilepticus at a tertiary care hospital 一家三级医院儿童癫痫持续状态的临床概况和短期结果
Pub Date : 2020-01-01 DOI: 10.33545/26643685.2020.v3.i1c.183
M. Patil, Abhineet Samant, V. S. Mantur, Dr. Sudarshan Reddy C
The condition known as status epilepticus is more common in children than it is in adults and can arise in a number of different contexts. It is most common in children who are ill with infections, as well as in patients who have a history of epilepsy, cerebral malformations, hypoxia, hypoglycemia
这种被称为癫痫持续状态的情况在儿童中比在成人中更常见,并且可以在许多不同的情况下出现。它最常见于患有感染的儿童,以及有癫痫、脑畸形、缺氧、低血糖病史的患者
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引用次数: 0
Pattern of admission and factors contributing to neonatal mortality: A small retrospective hospital based study 入院模式和影响新生儿死亡率的因素:一项基于医院的小型回顾性研究
Pub Date : 2019-07-01 DOI: 10.33545/26643685.2019.v2.i2a.32
Richa Sharma, P. Thakur, M. Basit
The neonatal period is a difficult time for a child’s survival. In India, neonatal mortality is high, and the pattern of reduction is very less as compared to infant and child mortality. The magnitude and associated factors of neonatal mortality in a tertiary care centres are also not well documented. Therefore, the aim of this study is to see the pattern of admission, neonatal mortality and its causes. Among the neonates admitted in neonatal intensive care unit of SLBSGMC and hospital.
新生儿期是儿童生存的艰难时期。在印度,新生儿死亡率很高,与婴儿和儿童死亡率相比,死亡率下降的幅度要小得多。三级保健中心新生儿死亡率的大小和相关因素也没有很好的记录。因此,本研究的目的是了解入院模式,新生儿死亡率及其原因。在SLBSGMC和医院新生儿重症监护病房住院的新生儿中。
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引用次数: 0
期刊
International Journal of Paediatrics and Geriatrics
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