Pub Date : 2023-06-19DOI: 10.52419/issn2072-2419.2023.1.105
M. Novikova, N. Pudovkin, N. I. Zakharkina, D. V. Vorobyev
The article presents the results of studies on the effect of the preparation "Aspartzinc" on the processes of lipid peroxidation and the activity of the antioxidant system of the pheasant organism. For the prevention of zinc deficiency conditions, various additives are often used recently. One of them is "Aspartzinc", which includes zinc aspartate. The aim of the work was to study the effect of the zinc preparation "Aspartzinc" on the processes of lipid peroxidation and the activity of the antioxidant defense system of the pheasant organism. The studies were carried out on pheasants of the North Caucasian breed. The birds were kept under the conditions of the State Budgetary Institution JSC "Directorate of the Southern Specialized Protected Areas and GOOH" Astrakhanskoye ". It has been established that the Asparzinc drug has an antioxidant effect and inhibits the processes of lipid peroxidation in the body of pheasants. It was found that after the administration of "Asparzinc" at doses of 1 mg/kg (experimental group 1) and 2 mg/kg (experimental group 2), the concentration of DC in the blood serum of pheasants decreased by 8.9% and 16.4%, respectively, relative to the initial values. The concentration of MDA in the tissues of the lungs also decreases by 14.6% (experimental group 1) and 13.5% (experimental group 2) and in the tissues of the pectoral muscle by 14.6% (dose 1 mg/kg) and 13.5% (dose 2 mg/kg), respectively, relative to the initial value.The antioxidant activity of the drug is expressed in an increase in catalase activity in the tissue of the liver, kidney and lungs after the administration of the Asparzinc preparation in birds of the 2nd experimental group, relative to the initial level. In the heart tissue after the introduction of the drug "Aspartzinc" in birds of the 1st and 2nd experimental groups, there was an increase in catalase activity by 9.8% and 14.5%, respectively, relative to the initial level.
{"title":"The effect of the zinc preparation \"asparzink\" on the processes of lipid peroxidation and the activity of the antioxidant system of the pheasant body","authors":"M. Novikova, N. Pudovkin, N. I. Zakharkina, D. V. Vorobyev","doi":"10.52419/issn2072-2419.2023.1.105","DOIUrl":"https://doi.org/10.52419/issn2072-2419.2023.1.105","url":null,"abstract":"The article presents the results of studies on the effect of the preparation \"Aspartzinc\" on the processes of lipid peroxidation and the activity of the antioxidant system of the pheasant organism. For the prevention of zinc deficiency conditions, various additives are often used recently. One of them is \"Aspartzinc\", which includes zinc aspartate. The aim of the work was to study the effect of the zinc preparation \"Aspartzinc\" on the processes of lipid peroxidation and the activity of the antioxidant defense system of the pheasant organism. The studies were carried out on pheasants of the North Caucasian breed. The birds were kept under the conditions of the State Budgetary Institution JSC \"Directorate of the Southern Specialized Protected Areas and GOOH\" Astrakhanskoye \". It has been established that the Asparzinc drug has an antioxidant effect and inhibits the processes of lipid peroxidation in the body of pheasants. It was found that after the administration of \"Asparzinc\" at doses of 1 mg/kg (experimental group 1) and 2 mg/kg (experimental group 2), the concentration of DC in the blood serum of pheasants decreased by 8.9% and 16.4%, respectively, relative to the initial values. The concentration of MDA in the tissues of the lungs also decreases by 14.6% (experimental group 1) and 13.5% (experimental group 2) and in the tissues of the pectoral muscle by 14.6% (dose 1 mg/kg) and 13.5% (dose 2 mg/kg), respectively, relative to the initial value.The antioxidant activity of the drug is expressed in an increase in catalase activity in the tissue of the liver, kidney and lungs after the administration of the Asparzinc preparation in birds of the 2nd experimental group, relative to the initial level. In the heart tissue after the introduction of the drug \"Aspartzinc\" in birds of the 1st and 2nd experimental groups, there was an increase in catalase activity by 9.8% and 14.5%, respectively, relative to the initial level.","PeriodicalId":14419,"journal":{"name":"International Journal of Veterinary Medicine","volume":"18 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-06-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87644993","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-06-16DOI: 10.52419/issn2072-2419.2023.1.79
A. Moiseeva
Diseases of bacterial etiology are a serious problem hindering the development of the poultry industry, causing serious economic damage to it.Herein we present the results of studies of the effect that drugs of different antimicrobial groups (ditrim and furazolidone) have on leukogram of Hisex Brown chicks. We studied blood values in 3 groups, group I received pure drinking water, group II received ditrim via drinking water at a concentration of 200 mg/L 10 consecutive days, whereas group III received furazolidone in the same manner. Blood samples were collected at Day 1, Day 3, Day 5, Day 7 and Day 9 after the drug withdrawal. We performed leukocyte count in chick blood in each group, then in blood smears we calculated the number of eosinophils, basophils, pseudoeosinophils, lymphocytes and monocytes. We also calculated percentages of separate white blood cell types in order to perform the white blood cell differential. We discovered that administration of furazolidone via drinking water causes a long-term decrease in leukocyte number while such decrease was not observed following administration of ditrim. Leukopenia was observed in chicks of group III at Day 1, Day 5 and Day 7, their values differing from the control values by 26%, 12% and 25% respectively. Besides the administration of furazolidone via drinking water caused changes in leukogram, manifesting in prolonged dynamics of pseudoeosinophil number and lymphocyte number, and also in transitory change in eosinophil number. We did not observe such effect on blood values following the administration of ditrim to the chicks of Group II, except for transitory eosinopenia at Day 9 of our experiment
{"title":"Comparative study of the effect of different antimicrobial groups on chick blood leukogram","authors":"A. Moiseeva","doi":"10.52419/issn2072-2419.2023.1.79","DOIUrl":"https://doi.org/10.52419/issn2072-2419.2023.1.79","url":null,"abstract":"Diseases of bacterial etiology are a serious problem hindering the development of the poultry industry, causing serious economic damage to it.Herein we present the results of studies of the effect that drugs of different antimicrobial groups (ditrim and furazolidone) have on leukogram of Hisex Brown chicks. We studied blood values in 3 groups, group I received pure drinking water, group II received ditrim via drinking water at a concentration of 200 mg/L 10 consecutive days, whereas group III received furazolidone in the same manner. Blood samples were collected at Day 1, Day 3, Day 5, Day 7 and Day 9 after the drug withdrawal. We performed leukocyte count in chick blood in each group, then in blood smears we calculated the number of eosinophils, basophils, pseudoeosinophils, lymphocytes and monocytes. We also calculated percentages of separate white blood cell types in order to perform the white blood cell differential. We discovered that administration of furazolidone via drinking water causes a long-term decrease in leukocyte number while such decrease was not observed following administration of ditrim. Leukopenia was observed in chicks of group III at Day 1, Day 5 and Day 7, their values differing from the control values by 26%, 12% and 25% respectively. Besides the administration of furazolidone via drinking water caused changes in leukogram, manifesting in prolonged dynamics of pseudoeosinophil number and lymphocyte number, and also in transitory change in eosinophil number. We did not observe such effect on blood values following the administration of ditrim to the chicks of Group II, except for transitory eosinopenia at Day 9 of our experiment","PeriodicalId":14419,"journal":{"name":"International Journal of Veterinary Medicine","volume":"205 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-06-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77734295","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-06-16DOI: 10.52419/issn2072-2419.2023.1.92
S. Dabravolski, Y. Kavalionak
Gastroenteritis in piglets after weaning is a common disease that significantly reduces feeding efficiency, impairs performance and leads to financial losses. In this paper, we have proposed a method for the prevention of gastroenteritis by neutralizing provender lectins with glucosamine (GluA). Lectin proteins are anti-nutritional factors in provender and one of the etiological factors causing gastroenteritis. In our in vitro experiments we found that GluA effectively neutralises provender lectins. Industrial pig farms testing of the use of 0.1 g of GluA per 1 kg of provender to neutralise provender lectins as a means of preventing gastroenteritis showed that GluA effectively reduces the incidence of gastroenteritis and the number of severe cases of the disease. In the experimental groups the disease developed in a later period, when the body is more adapted. The average duration of the disease, nonproductive disposal and the number of relapses were also lower, which demonstrate the high efficiency of GluA application at a dose of 0.1 g per 1 kg of provender for the prevention of gastroenteritis in piglets.
{"title":"The efficacy of glucosamine application for feed lectins neutralization as gastroenteritis prevention approach","authors":"S. Dabravolski, Y. Kavalionak","doi":"10.52419/issn2072-2419.2023.1.92","DOIUrl":"https://doi.org/10.52419/issn2072-2419.2023.1.92","url":null,"abstract":"Gastroenteritis in piglets after weaning is a common disease that significantly reduces feeding efficiency, impairs performance and leads to financial losses. In this paper, we have proposed a method for the prevention of gastroenteritis by neutralizing provender lectins with glucosamine (GluA). Lectin proteins are anti-nutritional factors in provender and one of the etiological factors causing gastroenteritis. In our in vitro experiments we found that GluA effectively neutralises provender lectins. Industrial pig farms testing of the use of 0.1 g of GluA per 1 kg of provender to neutralise provender lectins as a means of preventing gastroenteritis showed that GluA effectively reduces the incidence of gastroenteritis and the number of severe cases of the disease. In the experimental groups the disease developed in a later period, when the body is more adapted. The average duration of the disease, nonproductive disposal and the number of relapses were also lower, which demonstrate the high efficiency of GluA application at a dose of 0.1 g per 1 kg of provender for the prevention of gastroenteritis in piglets.","PeriodicalId":14419,"journal":{"name":"International Journal of Veterinary Medicine","volume":"77 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-06-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82312493","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-06-16DOI: 10.52419/issn2072-2419.2023.1.50
M. V. Khramchenkova
The last large-scale study of the parasite fauna of cats and dogs in St. Petersburg was carried out by Prozorov A.M. However, since then, according to sociological surveys, the number of animals in large cities of Russia has increased significantly, and no new studies on parasitic diseases of carnivores have been conducted. As the number of pets increases, so does the parasite population. Of particular danger are zoonotic invasions, in particular toxocariasis, dipilidiosis and toxoplasmosis. In the process of studying the species composition of parasites of carnivores, material from 608 animals from a number of districts of St. Petersburg and the Leningrad region was examined. As a result, the extensiveness of invasion in carnivores was established, which amounted to 23.7% (in cats 11.5%, in dogs - 12.2%). Cat toxocariasis is registered in every district and is in first place in terms of frequency of occurrence, with the exception of the Kalininsky district of St. Petersburg. The most common infestation of dogs, as well as in cats, in all the studied areas was toxocariasis, the prevalence of invasion of which in animals from centers for helping homeless animals and owners is 26.5% and 7.7%, respectively, which contributes to the contamination of the environment with toxocara eggs. Dipylidiasis is rare in carnivores (extensiveness of invasion was 0.2%) but has not been completely ruled out. The analysis led to the conclusion that the danger of infection with zoonotic invasions is preserved, therefore, it is necessary to carry out timely fight against diseases and carnivorous people, both in the centers for helping homeless animals, and in the owners of dogs and cats. It is also necessary to increase the level of people's knowledge about parasites, methods of infection and prevention, most common in humans and animals, invasive infections.
{"title":"Evaluation of the zoonotic potential of invasions of carnivores in a number of regions of St. Petersburg and the Lenigrad region","authors":"M. V. Khramchenkova","doi":"10.52419/issn2072-2419.2023.1.50","DOIUrl":"https://doi.org/10.52419/issn2072-2419.2023.1.50","url":null,"abstract":"The last large-scale study of the parasite fauna of cats and dogs in St. Petersburg was carried out by Prozorov A.M. However, since then, according to sociological surveys, the number of animals in large cities of Russia has increased significantly, and no new studies on parasitic diseases of carnivores have been conducted. As the number of pets increases, so does the parasite population. Of particular danger are zoonotic invasions, in particular toxocariasis, dipilidiosis and toxoplasmosis. In the process of studying the species composition of parasites of carnivores, material from 608 animals from a number of districts of St. Petersburg and the Leningrad region was examined. As a result, the extensiveness of invasion in carnivores was established, which amounted to 23.7% (in cats 11.5%, in dogs - 12.2%). Cat toxocariasis is registered in every district and is in first place in terms of frequency of occurrence, with the exception of the Kalininsky district of St. Petersburg. The most common infestation of dogs, as well as in cats, in all the studied areas was toxocariasis, the prevalence of invasion of which in animals from centers for helping homeless animals and owners is 26.5% and 7.7%, respectively, which contributes to the contamination of the environment with toxocara eggs. Dipylidiasis is rare in carnivores (extensiveness of invasion was 0.2%) but has not been completely ruled out. The analysis led to the conclusion that the danger of infection with zoonotic invasions is preserved, therefore, it is necessary to carry out timely fight against diseases and carnivorous people, both in the centers for helping homeless animals, and in the owners of dogs and cats. It is also necessary to increase the level of people's knowledge about parasites, methods of infection and prevention, most common in humans and animals, invasive infections.","PeriodicalId":14419,"journal":{"name":"International Journal of Veterinary Medicine","volume":"44 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-06-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81646000","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-06-16DOI: 10.52419/issn2072-2419.2023.1.85
E. M. Stepanov, V. Mikhalev, L. Sashnina, G. Chusova
The state of the immunobiochemical status of the blood of cows when using a drug containing gm-csf was studied on 15 animals with a hypofunctional state of the ovaries. The animals were divided according to the principle of analogues into three groups. The animals were included in the experiment 45- 60 days after calving without signs of sexual cyclicity. The cows of the first group were injected with a drug based on gm-csf (granulocyte-macrophage colony-stimulating factor), the cows of the second one - follimag, the third group served as a negative control without the introduction of drugs. Evaluation of the efficacy of the use of gonadotropic and recombinant drugs showed that the use of the agent based on gm-csf turned out to be the most effective in comparison with follimag and the negative control. After the use of the drug of recombinant interferons, the content of circulating immune complexes turned out to be lower by 30.9%, malon dialdehyde - by 17.1%, medium molecular peptides - by 34.9% TNFα - by 21.0%, IL-1β - by 41.1%, IL-2 - by 35.9%, with an increase in serum bactericidal and lysozyme activity by 13.8% and 21.7%, respectively, phagocytic index - by 12.9%, phagocytic number - by 18.4%, progesterone - by 5.09 times, estradiol - by 29.3%, dehydroepiandrosterone sulfate - by 78.9%, IL-4 - by 44.6%, IL-10 - by 20.3%, which indicates activation the humoral link of general nonspecific resistance, an increase in the content of anti-inflammatory cytokines, with a decrease in the intensity of lipid peroxidation processes, the level of proinflammatory cytokines against the background of the restoration of the hormoneproducing function of the sex gonads. Changes in the indicators of the immunobiochemical blood status of cows are reflected in the activation of the functional activity of the ovaries, the manifestation of full-fledged sexual cycles by animals and successful insemination.
{"title":"Changes in the indicators of immunobiochemical blood status of cows during correction of the functional activity of the ovaries with a drug based on GM-CSF","authors":"E. M. Stepanov, V. Mikhalev, L. Sashnina, G. Chusova","doi":"10.52419/issn2072-2419.2023.1.85","DOIUrl":"https://doi.org/10.52419/issn2072-2419.2023.1.85","url":null,"abstract":"The state of the immunobiochemical status of the blood of cows when using a drug containing gm-csf was studied on 15 animals with a hypofunctional state of the ovaries. The animals were divided according to the principle of analogues into three groups. The animals were included in the experiment 45- 60 days after calving without signs of sexual cyclicity. The cows of the first group were injected with a drug based on gm-csf (granulocyte-macrophage colony-stimulating factor), the cows of the second one - follimag, the third group served as a negative control without the introduction of drugs. Evaluation of the efficacy of the use of gonadotropic and recombinant drugs showed that the use of the agent based on gm-csf turned out to be the most effective in comparison with follimag and the negative control. After the use of the drug of recombinant interferons, the content of circulating immune complexes turned out to be lower by 30.9%, malon dialdehyde - by 17.1%, medium molecular peptides - by 34.9% TNFα - by 21.0%, IL-1β - by 41.1%, IL-2 - by 35.9%, with an increase in serum bactericidal and lysozyme activity by 13.8% and 21.7%, respectively, phagocytic index - by 12.9%, phagocytic number - by 18.4%, progesterone - by 5.09 times, estradiol - by 29.3%, dehydroepiandrosterone sulfate - by 78.9%, IL-4 - by 44.6%, IL-10 - by 20.3%, which indicates activation the humoral link of general nonspecific resistance, an increase in the content of anti-inflammatory cytokines, with a decrease in the intensity of lipid peroxidation processes, the level of proinflammatory cytokines against the background of the restoration of the hormoneproducing function of the sex gonads. Changes in the indicators of the immunobiochemical blood status of cows are reflected in the activation of the functional activity of the ovaries, the manifestation of full-fledged sexual cycles by animals and successful insemination.","PeriodicalId":14419,"journal":{"name":"International Journal of Veterinary Medicine","volume":"5 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-06-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89761150","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-06-16DOI: 10.52419/issn2072-2419.2023.1.28
A. Gusev, V. A. Babak
With the development of human society, the intensification of agricultural production, climatic changes, environmental pollution, which negatively affect human and animal health, significant changes are taking place in the micro-world. The experience of infectionists show that the most effective way of protection against bacterial, as well as many viral and parasitic diseases, are antibiotics and vaccines.The article provides an overview of immunobiological remedies of veterinary medicine - whole-corpuscular, subunit, genetically engineered, vector and DNA vaccines, vaccines based on virus-like particles and transgenic plants. Whole–body vaccines are live and inactivated biological products, consisting of bacteria or viruses, that retain their integrity during the manufacturing process. Subunit vaccines consist of fragments of infectious disease pathogens capable of providing a specific immune response against a specific pathogen. The technology of manufacturing vector genetically engineered vaccines is based on the use of the virus as a vector for the transfer of genes of protective antigens of other viruses. A gene of the virus of interest is inserted into the genome of the avirulent virus, encoding an antigen that causes an immune response in the vaccinated organism. The avirulent virus modified in this way is used as a live viral vaccine. For the prevention of viral and bacterial diseases in veterinary practice, currently, the advantage is still given to live and inactivated whole-cell biologics, which have a full set of antigens and create intense immunity against infections. The last is the promising direction is the work on the design of genetically engineered vector and DNA vaccines.
{"title":"Modern immunobiological preparations for veterinary medicine","authors":"A. Gusev, V. A. Babak","doi":"10.52419/issn2072-2419.2023.1.28","DOIUrl":"https://doi.org/10.52419/issn2072-2419.2023.1.28","url":null,"abstract":"With the development of human society, the intensification of agricultural production, climatic changes, environmental pollution, which negatively affect human and animal health, significant changes are taking place in the micro-world. The experience of infectionists show that the most effective way of protection against bacterial, as well as many viral and parasitic diseases, are antibiotics and vaccines.The article provides an overview of immunobiological remedies of veterinary medicine - whole-corpuscular, subunit, genetically engineered, vector and DNA vaccines, vaccines based on virus-like particles and transgenic plants. Whole–body vaccines are live and inactivated biological products, consisting of bacteria or viruses, that retain their integrity during the manufacturing process. Subunit vaccines consist of fragments of infectious disease pathogens capable of providing a specific immune response against a specific pathogen. The technology of manufacturing vector genetically engineered vaccines is based on the use of the virus as a vector for the transfer of genes of protective antigens of other viruses. A gene of the virus of interest is inserted into the genome of the avirulent virus, encoding an antigen that causes an immune response in the vaccinated organism. The avirulent virus modified in this way is used as a live viral vaccine. For the prevention of viral and bacterial diseases in veterinary practice, currently, the advantage is still given to live and inactivated whole-cell biologics, which have a full set of antigens and create intense immunity against infections. The last is the promising direction is the work on the design of genetically engineered vector and DNA vaccines.","PeriodicalId":14419,"journal":{"name":"International Journal of Veterinary Medicine","volume":"9 39 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-06-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80546497","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-06-16DOI: 10.52419/issn2072-2419.2023.1.71
R. Vasiliev
Modern technologies of cattle breeding imply the maximum use of the productive potential of animals, the realization of which is hindered by various diseases, one of which is genital mycoplasmosis. According to domestic and foreign scientists, this disease is quite widespread in livestock enterprises. Considering that mycoplasmosis is characterized by a long latent period, its diagnosis is associated with a number of difficulties, therefore, a significant role belongs to the diagnostic aspects of immuno-metabolic changes occurring in the body. In addition, it is necessary for the development of rational therapy. We have studied the effect of tulatromycin therapy in patients with genital mycoplasmosis of cows on the content of total protein, absolute and relative content of albumins and globulins, immunoglobulins and their classes in blood serum. For the experiment, 3 groups of animals were formed: the first - cows with mycoplasmosis (without treatment); the second - cows with mycoplasmosis, for the treatment of which tulatromycin was used; the third – clinically healthy cows (control). The results of studies have shown that the use of tulatromycin in this disease leads to the recovery of 75% of infected animals. significant redistribution of the content of immunoglobulins in the blood serum of cows. An increase in the content of Ig G by 44% and a decrease in the concentration of Ig M and Ig A by 37% and 31.5%, respectively, were found. However, the indicators characterizing the state of protein metabolism, except for the total protein content, did not undergo significant changes
{"title":"The effect of tulatromycin therapy on the immune status of cows with mycoplasmosis and calves born by them","authors":"R. Vasiliev","doi":"10.52419/issn2072-2419.2023.1.71","DOIUrl":"https://doi.org/10.52419/issn2072-2419.2023.1.71","url":null,"abstract":"Modern technologies of cattle breeding imply the maximum use of the productive potential of animals, the realization of which is hindered by various diseases, one of which is genital mycoplasmosis. According to domestic and foreign scientists, this disease is quite widespread in livestock enterprises. Considering that mycoplasmosis is characterized by a long latent period, its diagnosis is associated with a number of difficulties, therefore, a significant role belongs to the diagnostic aspects of immuno-metabolic changes occurring in the body. In addition, it is necessary for the development of rational therapy. We have studied the effect of tulatromycin therapy in patients with genital mycoplasmosis of cows on the content of total protein, absolute and relative content of albumins and globulins, immunoglobulins and their classes in blood serum. For the experiment, 3 groups of animals were formed: the first - cows with mycoplasmosis (without treatment); the second - cows with mycoplasmosis, for the treatment of which tulatromycin was used; the third – clinically healthy cows (control). The results of studies have shown that the use of tulatromycin in this disease leads to the recovery of 75% of infected animals. significant redistribution of the content of immunoglobulins in the blood serum of cows. An increase in the content of Ig G by 44% and a decrease in the concentration of Ig M and Ig A by 37% and 31.5%, respectively, were found. However, the indicators characterizing the state of protein metabolism, except for the total protein content, did not undergo significant changes","PeriodicalId":14419,"journal":{"name":"International Journal of Veterinary Medicine","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-06-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83413992","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-06-16DOI: 10.52419/issn2072-2419.2023.1.45
A. S. Gorbaneva, V. Skvortsov, A. Mazur, A. Laishevtsev
Salmonellosis is one of the most widespread zoonoses. Control of salmonellosis is becoming a matter of great importance as the number of cases of Salmonella infection increases, new Salmonella serovars emerge and the bacteria contaminate food products and environment easily. Salmonella infantis is one of the most common serovars among those isolated recently from poultry products and meat products and that translates into need to develop new and effective treatment methods concerning infection caused by this serovar. In the present publication we study the comparative effectiveness of different antimicrobials selected for therapy of chicks, which have been experimentally infected with Salmonella infantis. For the experiment we employed as many as 275 Hisex Brown chicks which we had divided into 11 groups (n = 25 in each group). We administered the drugs via drinking water at a concentration 200 mg/L for 5 days. The treatment began 24 hours before the challenge. On the second day of life the chicks were challenged by intraperitoneal injection with 1.5 x 10^8 CFUs of one-day old agar culture of S. infantis in 0.5 mL isotonic saline (1 McFarland). The observation period in the experiment was 15 days following the drug withdrawal. The study of comparative effectiveness of aforementioned drugs for treatment of chicks, infected with S. infantis, demonstrated the highest therapeutic effectiveness of fluoroquinolone class of antimicrobials. The survival rate for the chicks, receiving enrofloxacin and ciprofloxacin, was 96 %. The survival rate for the chicks, receiving ofloxacin per os, was 92 %. Tilmicosin and chloramphenicol showed lower therapeutic effectiveness, 44 % and 36 % respectively. When we used tylosin, amoxycillin, doxycycline or apramycin, the results were at their worst as the mortality rate of the chicks was 80-96 %.
{"title":"Comparative effectiveness of antimicrobials in experimental infection of chicks with salmonella infantis","authors":"A. S. Gorbaneva, V. Skvortsov, A. Mazur, A. Laishevtsev","doi":"10.52419/issn2072-2419.2023.1.45","DOIUrl":"https://doi.org/10.52419/issn2072-2419.2023.1.45","url":null,"abstract":"Salmonellosis is one of the most widespread zoonoses. Control of salmonellosis is becoming a matter of great importance as the number of cases of Salmonella infection increases, new Salmonella serovars emerge and the bacteria contaminate food products and environment easily. Salmonella infantis is one of the most common serovars among those isolated recently from poultry products and meat products and that translates into need to develop new and effective treatment methods concerning infection caused by this serovar. In the present publication we study the comparative effectiveness of different antimicrobials selected for therapy of chicks, which have been experimentally infected with Salmonella infantis. For the experiment we employed as many as 275 Hisex Brown chicks which we had divided into 11 groups (n = 25 in each group). We administered the drugs via drinking water at a concentration 200 mg/L for 5 days. The treatment began 24 hours before the challenge. On the second day of life the chicks were challenged by intraperitoneal injection with 1.5 x 10^8 CFUs of one-day old agar culture of S. infantis in 0.5 mL isotonic saline (1 McFarland). The observation period in the experiment was 15 days following the drug withdrawal. The study of comparative effectiveness of aforementioned drugs for treatment of chicks, infected with S. infantis, demonstrated the highest therapeutic effectiveness of fluoroquinolone class of antimicrobials. The survival rate for the chicks, receiving enrofloxacin and ciprofloxacin, was 96 %. The survival rate for the chicks, receiving ofloxacin per os, was 92 %. Tilmicosin and chloramphenicol showed lower therapeutic effectiveness, 44 % and 36 % respectively. When we used tylosin, amoxycillin, doxycycline or apramycin, the results were at their worst as the mortality rate of the chicks was 80-96 %.","PeriodicalId":14419,"journal":{"name":"International Journal of Veterinary Medicine","volume":"28 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-06-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79120304","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-06-16DOI: 10.52419/issn2072-2419.2023.1.40
N. Gavrilova, L. Belova
The importance and necessity of confirming the diagnosis of tick-borne borreliosis (Lyme disease) in dogs at the initial stages is due to the possibility of timely prescribing specific treatment and reducing the recovery time of animals. In the conditions of a veterinary clinic in St. Petersburg, tick-borne borreliosis was diagnosed in dogs, taking into account the parasitism of ixodid ticks, erythema at the site of their attachment, depression, lowgrade fever, anorexia, lameness, paraplegia, and confirmed by the PCR. In dogs of one of the experimental groups, after removing the ticks, the Borrelia Test test system was used to detect the pathogen Borrelia burgdorferi. Dogs were treated with tertacycline preparations - "Doxycycline", "Doxyfin" and fluoroquinolones - "Enroflaxocin". It was found that the oral administration of drugs "Doxycycline" and "Doxyfin" to dogs at the rate of 10 mg / kg of animal weight, 1 time per day, for 28 days is equally effective in Lyme disease. The alternation of the use of bacteriostatic antibiotics of the tetracycline series and fluoroquinolones has a greater therapeutic efficacy compared to the use of only drugs of the tetracycline group. The use of drugs "Enroflaxocin" and "Doxycycline" reduced the recovery time of animals to three weeks compared to 28 days when animals were treated only with tetracycline antibiotics. The early timing of the detection of borrelia in ixodid ticks made it possible to timely prescribe treatment to animals. In dogs of this group, it was possible to avoid the development of a severe course of tick-borne borreliosis, accompanied by a long period of fever, the development of signs of anorexia, depression, lameness, and the use of drugs from the fluoroquinolones and tetracyclines groups reduced the recovery time of animals to two weeks
{"title":"Dependence of treatment effectiveness in dogs ticke-borreliosis from the time of diagnosis","authors":"N. Gavrilova, L. Belova","doi":"10.52419/issn2072-2419.2023.1.40","DOIUrl":"https://doi.org/10.52419/issn2072-2419.2023.1.40","url":null,"abstract":"The importance and necessity of confirming the diagnosis of tick-borne borreliosis (Lyme disease) in dogs at the initial stages is due to the possibility of timely prescribing specific treatment and reducing the recovery time of animals. In the conditions of a veterinary clinic in St. Petersburg, tick-borne borreliosis was diagnosed in dogs, taking into account the parasitism of ixodid ticks, erythema at the site of their attachment, depression, lowgrade fever, anorexia, lameness, paraplegia, and confirmed by the PCR. In dogs of one of the experimental groups, after removing the ticks, the Borrelia Test test system was used to detect the pathogen Borrelia burgdorferi. Dogs were treated with tertacycline preparations - \"Doxycycline\", \"Doxyfin\" and fluoroquinolones - \"Enroflaxocin\". It was found that the oral administration of drugs \"Doxycycline\" and \"Doxyfin\" to dogs at the rate of 10 mg / kg of animal weight, 1 time per day, for 28 days is equally effective in Lyme disease. The alternation of the use of bacteriostatic antibiotics of the tetracycline series and fluoroquinolones has a greater therapeutic efficacy compared to the use of only drugs of the tetracycline group. The use of drugs \"Enroflaxocin\" and \"Doxycycline\" reduced the recovery time of animals to three weeks compared to 28 days when animals were treated only with tetracycline antibiotics. The early timing of the detection of borrelia in ixodid ticks made it possible to timely prescribe treatment to animals. In dogs of this group, it was possible to avoid the development of a severe course of tick-borne borreliosis, accompanied by a long period of fever, the development of signs of anorexia, depression, lameness, and the use of drugs from the fluoroquinolones and tetracyclines groups reduced the recovery time of animals to two weeks","PeriodicalId":14419,"journal":{"name":"International Journal of Veterinary Medicine","volume":"53 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-06-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88398204","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-06-16DOI: 10.52419/issn2072-2419.2023.1.57
G. Bondarenko, I. Solovyova, T. I. Trukhina
The problem of trichinosis on the territory of the Far East has a pronounced natural focal character with the predominant circulation of the causative agent of trichinosis in wild animals. The main species circulating in the Amur Region is the capsule- forming species T. spiralis. The ability to form capsules is one of the biological features of Trichinella larvae and a necessary component of the process of their survival. The thickness of the walls of the capsule gradually increases while the larva and intracapsular muscle sarcoplasm with nuclei remain alive. At the same time, the morphological variability of Trichinella capsules under the influence of many ecological and biological factors was noted.The goal is to determine the morphological features of the capsules of Trichinella larvae in wild animals in the Amur region.We conducted studies of the muscle tissues of wild animals by the method of compressor trichinelloscopy and the method of digestion in artificial gastric juice, according to MUK 4.2.2747-10 "Methods of sanitary and parasitological examination of meat and meat products" to determine the presence of Trichinella larvae. To establish the morphological features, the length and width of the capsules, the thickness of the capsule wall from the sides and at the poles, and the thickness of the larva itself were determined using an eyepiece micrometer. The capsule shape index (V) was calculated as the ratio of the diameter to its length (V=D/L). The shape of capsules of Trichinella larvae in different species of wild animals was determined. The relationship between the morphological parameters of the capsule of the larvae of Trichinella has been established. Indicators of the thickness of the wall of the capsule from the sides and the thickness of the wall of the capsule at the poles can be used to determine the age of Trichinella larvae.
{"title":"Morphological features of capsules of trichinella larvae in wild animals of the amur region","authors":"G. Bondarenko, I. Solovyova, T. I. Trukhina","doi":"10.52419/issn2072-2419.2023.1.57","DOIUrl":"https://doi.org/10.52419/issn2072-2419.2023.1.57","url":null,"abstract":"The problem of trichinosis on the territory of the Far East has a pronounced natural focal character with the predominant circulation of the causative agent of trichinosis in wild animals. The main species circulating in the Amur Region is the capsule- forming species T. spiralis. The ability to form capsules is one of the biological features of Trichinella larvae and a necessary component of the process of their survival. The thickness of the walls of the capsule gradually increases while the larva and intracapsular muscle sarcoplasm with nuclei remain alive. At the same time, the morphological variability of Trichinella capsules under the influence of many ecological and biological factors was noted.The goal is to determine the morphological features of the capsules of Trichinella larvae in wild animals in the Amur region.We conducted studies of the muscle tissues of wild animals by the method of compressor trichinelloscopy and the method of digestion in artificial gastric juice, according to MUK 4.2.2747-10 \"Methods of sanitary and parasitological examination of meat and meat products\" to determine the presence of Trichinella larvae. To establish the morphological features, the length and width of the capsules, the thickness of the capsule wall from the sides and at the poles, and the thickness of the larva itself were determined using an eyepiece micrometer. The capsule shape index (V) was calculated as the ratio of the diameter to its length (V=D/L). The shape of capsules of Trichinella larvae in different species of wild animals was determined. The relationship between the morphological parameters of the capsule of the larvae of Trichinella has been established. Indicators of the thickness of the wall of the capsule from the sides and the thickness of the wall of the capsule at the poles can be used to determine the age of Trichinella larvae.","PeriodicalId":14419,"journal":{"name":"International Journal of Veterinary Medicine","volume":"28 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-06-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88405311","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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