S. Sahinler, B. Sever Yılmaz, Cengiz SarikÜrkcÜ, B. Tepe
Lavandula stoechas is distributed in Africa, Europe, and Asia continents, especially in the countries of Southern Europe and North Africa neighboring the Mediterranean. The use of L. stoechas, which has a cosmopolitan distribution, mainly in the Mediterranean region, in the treatment of rheumatic diseases and reduction of inflammatory problems in folk medicine dates back to ancient times. It has been determined that L. stoechas contains various bioactive phytochemicals such as flavonoids, catechic tannins, sterols, coumarins, leucoanthocyanins, and mucilages. The essential oil obtained from the leaves and flowers is widely used in pharmacy. There are ethnobotanical and phytopharmacological studies on the antimicrobial, insecticidal, antileishmanial, antioxidant, and anti-inflammatory effects of the essential oil and extracts of the plant. There are intensive studies and clinical data on its anti-inflammatory, antimicrobial, antioxidant, and anticonvulsant effects. It has been determined that L. stoechas has anti-inflammatory, antioxidant, antimicrobial, insecticide, larvicide, anticonvulsant, antispasmodic, sedative, hepatoprotective, nephroprotective, antidiabetic, and anticancer effects with scientific studies based on the traditional use of L. stoechas. This review supports that the aforementioned plant can be used as a medicine in the light of its traditional use and the data obtained as a result of scientific studies. In this review, it was emphasized that some regulations should be made on the cultivation, formulation, and marketing of L. stoechas.
{"title":"The importance of Lavandula stoechas L. in pharmacognosy and phytotherapy","authors":"S. Sahinler, B. Sever Yılmaz, Cengiz SarikÜrkcÜ, B. Tepe","doi":"10.21448/ijsm.1098975","DOIUrl":"https://doi.org/10.21448/ijsm.1098975","url":null,"abstract":"Lavandula stoechas is distributed in Africa, Europe, and Asia continents, especially in the countries of Southern Europe and North Africa neighboring the Mediterranean. The use of L. stoechas, which has a cosmopolitan distribution, mainly in the Mediterranean region, in the treatment of rheumatic diseases and reduction of inflammatory problems in folk medicine dates back to ancient times. It has been determined that L. stoechas contains various bioactive phytochemicals such as flavonoids, catechic tannins, sterols, coumarins, leucoanthocyanins, and mucilages. The essential oil obtained from the leaves and flowers is widely used in pharmacy. There are ethnobotanical and phytopharmacological studies on the antimicrobial, insecticidal, antileishmanial, antioxidant, and anti-inflammatory effects of the essential oil and extracts of the plant. There are intensive studies and clinical data on its anti-inflammatory, antimicrobial, antioxidant, and anticonvulsant effects. It has been determined that L. stoechas has anti-inflammatory, antioxidant, antimicrobial, insecticide, larvicide, anticonvulsant, antispasmodic, sedative, hepatoprotective, nephroprotective, antidiabetic, and anticancer effects with scientific studies based on the traditional use of L. stoechas. This review supports that the aforementioned plant can be used as a medicine in the light of its traditional use and the data obtained as a result of scientific studies. In this review, it was emphasized that some regulations should be made on the cultivation, formulation, and marketing of L. stoechas.","PeriodicalId":14437,"journal":{"name":"International Journal of Secondary Metabolite","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68256948","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Fadhilatul Ula, M. Prawira-Atmaja, H. Maulana, S. Harianto, S. Shabri, Dede Zainal Arief
Fixation is essential in green tea processing to inactivate the polyphenol oxidase enzyme. In Indonesia, green tea is made from the Assam variety and produced using the panning method. Few studies are reported on green tea made from Indonesian clones of the Sinensis variety. This study aims to identify chemical characteristics, antioxidant activity, and sensory evaluation of green tea from local clones of the Sinensis variety (GMBS 2, GMBS 4, and GMBS 5) with different fixation methods (panning and steaming). The results show that the caffeine content of green tea products ranged from 2.51-2.59% and 2.67-2.74% for panning and steaming methods. The panning method produced green tea with higher total polyphenol and flavonoid content than the steaming method. Green tea with the panning method has an IC50 value of 14.45; 14.41; and 17.41 mg/L for GMBS 2, GMBS 4, and GMBS 5, respectively. The panning method resulted in a smaller IC50 value than the steaming method for GMBS 2 and GMBS 4 clones. The steaming method produced green tea with a higher taste, aroma, and total score than those the panning method. However, different fixation methods did not significantly affect the appearance, liquor color, and leaf infusion. In conclusion, different fixation methods on GMBS 2, GMB 4, and GMB 5 produced green tea products that met the Indonesian National Standard 3945:2016. Further research is needed to determine the role of the plucking period/season and the characteristics of volatile compounds of green tea from GMBS clones with different fixation methods.
{"title":"Effect of fixation methods and various clones of Camellia sinensis var. sinensis (L) properties and antioxidant activity of Indonesian green tea","authors":"Fadhilatul Ula, M. Prawira-Atmaja, H. Maulana, S. Harianto, S. Shabri, Dede Zainal Arief","doi":"10.21448/ijsm.1014894","DOIUrl":"https://doi.org/10.21448/ijsm.1014894","url":null,"abstract":"Fixation is essential in green tea processing to inactivate the polyphenol oxidase enzyme. In Indonesia, green tea is made from the Assam variety and produced using the panning method. Few studies are reported on green tea made from Indonesian clones of the Sinensis variety. This study aims to identify chemical characteristics, antioxidant activity, and sensory evaluation of green tea from local clones of the Sinensis variety (GMBS 2, GMBS 4, and GMBS 5) with different fixation methods (panning and steaming). The results show that the caffeine content of green tea products ranged from 2.51-2.59% and 2.67-2.74% for panning and steaming methods. The panning method produced green tea with higher total polyphenol and flavonoid content than the steaming method. Green tea with the panning method has an IC50 value of 14.45; 14.41; and 17.41 mg/L for GMBS 2, GMBS 4, and GMBS 5, respectively. The panning method resulted in a smaller IC50 value than the steaming method for GMBS 2 and GMBS 4 clones. The steaming method produced green tea with a higher taste, aroma, and total score than those the panning method. However, different fixation methods did not significantly affect the appearance, liquor color, and leaf infusion. In conclusion, different fixation methods on GMBS 2, GMB 4, and GMB 5 produced green tea products that met the Indonesian National Standard 3945:2016. Further research is needed to determine the role of the plucking period/season and the characteristics of volatile compounds of green tea from GMBS clones with different fixation methods.","PeriodicalId":14437,"journal":{"name":"International Journal of Secondary Metabolite","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46250990","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Olive tree (Olea europaea L.) leaf is known to have a number of bioactive properties being antioxidant, antihypertensive, antiatherogenic, anti-inflammatory, antifungal, antiviral and antimicrobial. In this study, the immunomodulatory roles of Olive tree (Olea europaea L.) leaf against oxidative damage caused by carbon tetrachloride (CCl4) in Saccharomyces cerevisiae were investigated. In the study, four groups were formed; namely, (i) Control Group: Yeast only planted group; (ii) CCl4 Group: Group given CCl4 (15 mM); (iii) Olive Tree Leaf Group: The group given olive tree leaf (10%); and (iv) Olive Tree Leaf + CCl4 Group: Olive tree leaf (10%) + CCl4 (15 mM) given group. Cultures of Saccharomyces cerevisiae were grown at 30 °C for 1, 3, 5, and 24 hours. Malondialdehyde (MDA), glutathione levels (GSH), cell growth and catalase (CAT) activity measurements were determined by spectrophotometer. Total protein concentrations were determined by SDS-PAGE electrophoresis and the Bradford protein method. According to the results obtained; compared to the CCl4 group, cell growth (1, 3, 5 and 24 hours), total protein synthesis, and GSH and CAT activities (24 hours) increased in olive tree leaf groups, while MDA level (24 hours) decreased. Thanks to its strong bioactive properties, olive tree leaf has been found to increase cell growth and total protein synthesis by decreasing CCl4 induced oxidative stress in Saccharomyces cerevisiae culture. It has been concluded that if the olive tree leaf is used regularly, it will be beneficial in eliminating many health problems.
{"title":"A research paper on the immunomodulatory and anti-inflammatory activities of olive tree (Olea europaea L.) leaf","authors":"S. Beyaz, Özlem Gök, A. Aslan","doi":"10.21448/ijsm.1075283","DOIUrl":"https://doi.org/10.21448/ijsm.1075283","url":null,"abstract":"Olive tree (Olea europaea L.) leaf is known to have a number of bioactive properties being antioxidant, antihypertensive, antiatherogenic, anti-inflammatory, antifungal, antiviral and antimicrobial. In this study, the immunomodulatory roles of Olive tree (Olea europaea L.) leaf against oxidative damage caused by carbon tetrachloride (CCl4) in Saccharomyces cerevisiae were investigated. In the study, four groups were formed; namely, (i) Control Group: Yeast only planted group; (ii) CCl4 Group: Group given CCl4 (15 mM); (iii) Olive Tree Leaf Group: The group given olive tree leaf (10%); and (iv) Olive Tree Leaf + CCl4 Group: Olive tree leaf (10%) + CCl4 (15 mM) given group. Cultures of Saccharomyces cerevisiae were grown at 30 °C for 1, 3, 5, and 24 hours. Malondialdehyde (MDA), glutathione levels (GSH), cell growth and catalase (CAT) activity measurements were determined by spectrophotometer. Total protein concentrations were determined by SDS-PAGE electrophoresis and the Bradford protein method. According to the results obtained; compared to the CCl4 group, cell growth (1, 3, 5 and 24 hours), total protein synthesis, and GSH and CAT activities (24 hours) increased in olive tree leaf groups, while MDA level (24 hours) decreased. Thanks to its strong bioactive properties, olive tree leaf has been found to increase cell growth and total protein synthesis by decreasing CCl4 induced oxidative stress in Saccharomyces cerevisiae culture. It has been concluded that if the olive tree leaf is used regularly, it will be beneficial in eliminating many health problems.","PeriodicalId":14437,"journal":{"name":"International Journal of Secondary Metabolite","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49133898","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ahmed Elkhalifa Chemsa, Noura Gheraissa, Eman RAMADAN ELSHARKAWY, Nezar Cherrada
Current study verifies the biological efficiency of Bassia muricata (Chenopodiaceae vent), a wild plant in the Algerian desert. MeOH extract (70%) of the aerial parts of B. muricata was tested for antibacterial, anti-inflammatory and antioxidant activities. In addition to determining the value of the SPF and its effectiveness as hypoglycemia through a glucose uptake assay by yeast cells. Its phenolic content was also verified by quantitative estimations and RP-HPLC-UV analysis. MeOH extract of B. muricata exhibited antioxidant effects, where it showed good to moderate free radical inhibition activity towards both DPPH• and OH•, and this corresponded with excellent anti-hemolytic activity. As well as being a Fe2+ and molybdate reducing agent, the extract showed moderate photoprotective activity with SPFSpectrophootometric=18.89±0.005. It also has anti-inflammatory properties and enhances glucose uptake. MeOH extract of B. muricata showed remarkable antibacterial activity against B. subtilis, L. innocua, S. aureus, E. coli and P. aeruginosa. It did not give efficacy against S. typhimurium. Its phenolic content on the other hand was verified by quantitative estimations and RP-HPLC-UV analysis, which revealed the presence of chlorogenic acid, p-coumarin acid, gallic acid as a major phenolic compounds. These results showed that B. muricata could be useful as source of bioactive compounds for food, the pharmaceutical industry and the manufacture of cosmetics.
{"title":"Phenolic compound profile, and evaluation of biological properties of Bassia muricata (L.) Asch. aerial part","authors":"Ahmed Elkhalifa Chemsa, Noura Gheraissa, Eman RAMADAN ELSHARKAWY, Nezar Cherrada","doi":"10.21448/ijsm.1080537","DOIUrl":"https://doi.org/10.21448/ijsm.1080537","url":null,"abstract":"Current study verifies the biological efficiency of Bassia muricata (Chenopodiaceae vent), a wild plant in the Algerian desert. MeOH extract (70%) of the aerial parts of B. muricata was tested for antibacterial, anti-inflammatory and antioxidant activities. In addition to determining the value of the SPF and its effectiveness as hypoglycemia through a glucose uptake assay by yeast cells. Its phenolic content was also verified by quantitative estimations and RP-HPLC-UV analysis. MeOH extract of B. muricata exhibited antioxidant effects, where it showed good to moderate free radical inhibition activity towards both DPPH• and OH•, and this corresponded with excellent anti-hemolytic activity. As well as being a Fe2+ and molybdate reducing agent, the extract showed moderate photoprotective activity with SPFSpectrophootometric=18.89±0.005. It also has anti-inflammatory properties and enhances glucose uptake. MeOH extract of B. muricata showed remarkable antibacterial activity against B. subtilis, L. innocua, S. aureus, E. coli and P. aeruginosa. It did not give efficacy against S. typhimurium. Its phenolic content on the other hand was verified by quantitative estimations and RP-HPLC-UV analysis, which revealed the presence of chlorogenic acid, p-coumarin acid, gallic acid as a major phenolic compounds. \u0000These results showed that B. muricata could be useful as source of bioactive compounds for food, the pharmaceutical industry and the manufacture of cosmetics.","PeriodicalId":14437,"journal":{"name":"International Journal of Secondary Metabolite","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46462861","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Hydrolysis and dehydration reactions of carbohydrates, which are used as energy raw materials by all living things in nature, are controlled by Carbohydrate Active Enzyme (CAZy) systems. These enzymes are also used in different industrial areas today. There are different types of microorganisms that have the CAZy system and are used in the industrial sector. Apart from current organisms, there are also rumen fungi within the group of candidate microorganisms with the CAZy system. It has been reported that xylanase (EC3.2.1.8 and EC3.2.1.37) enzyme, a member of the glycoside hydrolase enzyme family obtained from Trichoderma sp. and used especially in areas such as bread, paper, and feed industry, is more synthesized in rumen fungi such as Orpinomyces sp. and Neocallimastix sp. Therefore, this study reviews Neocallimastixsp., Orpinomyces sp., Caecomyces sp., Piromyces sp., and Anaeromyces sp., registered in the CAZy and Mycocosm database for rumen fungi to have both CAZy enzyme activity and to be an alternative microorganism in the industry. Furthermore the CAZy enzyme activities of the strains are investigated. The review shows thatNeocallimax sp. and Orpinomyces sp. areconsidered as candidate microorganisms.
{"title":"Carbohydrate active enzyme system in rumen fungi: a review","authors":"H. Yücel, Kübra Ekinci","doi":"10.21448/ijsm.1075030","DOIUrl":"https://doi.org/10.21448/ijsm.1075030","url":null,"abstract":"Hydrolysis and dehydration reactions of carbohydrates, which are used as energy raw materials by all living things in nature, are controlled by Carbohydrate Active Enzyme (CAZy) systems. These enzymes are also used in different industrial areas today. There are different types of microorganisms that have the CAZy system and are used in the industrial sector. Apart from current organisms, there are also rumen fungi within the group of candidate microorganisms with the CAZy system. It has been reported that xylanase (EC3.2.1.8 and EC3.2.1.37) enzyme, a member of the glycoside hydrolase enzyme family obtained from Trichoderma sp. and used especially in areas such as bread, paper, and feed industry, is more synthesized in rumen fungi such as Orpinomyces sp. and Neocallimastix sp. Therefore, this study reviews Neocallimastixsp., Orpinomyces sp., Caecomyces sp., Piromyces sp., and Anaeromyces sp., registered in the CAZy and Mycocosm database for rumen fungi to have both CAZy enzyme activity and to be an alternative microorganism in the industry. Furthermore the CAZy enzyme activities of the strains are investigated. The review shows thatNeocallimax sp. and Orpinomyces sp. areconsidered as candidate microorganisms.","PeriodicalId":14437,"journal":{"name":"International Journal of Secondary Metabolite","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41427671","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Phytochemical investigation of Helianthemum lippii l. aerial Dum.Cours part and evaluation for its antioxidant activities","authors":"Ibtissam Laib, Ali Boutlelis Djahra","doi":"10.21448/ijsm.999518","DOIUrl":"https://doi.org/10.21448/ijsm.999518","url":null,"abstract":"","PeriodicalId":14437,"journal":{"name":"International Journal of Secondary Metabolite","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48000899","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"The Use of Organic Sun-Dried Fruits for Delivery of Phenolic Compounds","authors":"Gökhan Dervi̇şoğlu, A. Yemenicioğlu","doi":"10.21448/ijsm.1078277","DOIUrl":"https://doi.org/10.21448/ijsm.1078277","url":null,"abstract":"","PeriodicalId":14437,"journal":{"name":"International Journal of Secondary Metabolite","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44387619","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Antiproliferative and antioxidant potential of methanol extracts of aerial parts of Colchicum boissieri and Colchicum balansae","authors":"M. Alper","doi":"10.21448/ijsm.1056920","DOIUrl":"https://doi.org/10.21448/ijsm.1056920","url":null,"abstract":"","PeriodicalId":14437,"journal":{"name":"International Journal of Secondary Metabolite","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41712385","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Y. Melaku, T. Getahun, Markos Addi̇su, H. Tesso, R. Eswaramoorthy, A. Garg
{"title":"Molecular Docking, Antibacterial and Antioxidant Activities of Compounds Isolated from Ethiopian Plants","authors":"Y. Melaku, T. Getahun, Markos Addi̇su, H. Tesso, R. Eswaramoorthy, A. Garg","doi":"10.21448/ijsm.1023864","DOIUrl":"https://doi.org/10.21448/ijsm.1023864","url":null,"abstract":"","PeriodicalId":14437,"journal":{"name":"International Journal of Secondary Metabolite","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42575543","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Antioxidant Activities and Chemical Composition of Essential Oil of Rhizomes of Zingiber officinale (Ginger) and Curcuma longa L.(Turmeric)","authors":"Ü. Erdoğan","doi":"10.21448/ijsm.993906","DOIUrl":"https://doi.org/10.21448/ijsm.993906","url":null,"abstract":"","PeriodicalId":14437,"journal":{"name":"International Journal of Secondary Metabolite","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42296376","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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