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Antioxidant and antimicrobial activities of methanol extracts from Adonis paryadrica (Ranunculaceae) – a critically endangered endemic species growing in the Turkish flora 土耳其一种濒危特有物种——毛茛科(Adonis paryadrica)甲醇提取物的抗氧化和抗菌活性
Pub Date : 2023-03-26 DOI: 10.21448/ijsm.1271974
Mustafa CÜCE
This study was conducted to determine the antioxidant and antimicrobial activities of methanol extract obtained from flower, leaf and root sections of endemic Adonis paryadrica (Boiss.) Kandemir & Aytaç stat. nova. naturally growing in the Turkish flora. The most efficient total phenolic compounds and flavonoid contents were obtained from leaf extract at 21.24 mg GAEs (gallic acid equivalent)/g dw and 54.97 mg REs (rutin equivalent)/g dw, respectively. Among the three different sections of this plant, leaf extracts showed the highest Cupric Reducing Antioxidant Power (CUPRAC) effect with 80.28 µmol TEs (trolox equivalent)/g dw. From the three different sections, the methanol extract of the leaf parts demonstrated strong antibacterial activity against Bacillus subtilis with a 16.1 mm zone diameter. These valuable and current findings from these precious plants, which constitute natural resources in terms of biodiversity, contribute innovative information to the literature on endemic plant species.
摘要本研究主要研究了特有植物Adonis paryadrica (Boiss.)花、叶和根的甲醇提取物的抗氧化和抗菌活性。Kandemir, amp;Aytaç stat. nova。土耳其植物区系中自然生长的。以21.24 mg GAEs(没食子酸当量)/g dw和54.97 mg REs(芦丁当量)/g dw处理时,总酚类化合物和类黄酮含量最高。在该植物的三个不同部位中,叶片提取物的cu还原抗氧化能力(CUPRAC)最高,为80.28µmol TEs (trolox equivalent)/g dw。从三个不同的切片来看,叶部甲醇提取物对枯草芽孢杆菌的抑菌活性较强,其区直径为16.1 mm。这些珍贵植物是生物多样性的自然资源,它们的最新发现为地方性植物物种的研究提供了新的信息。
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引用次数: 0
A systematic review on Hammada scoparia medicinal plant: Phytochemicals, traditional uses and biological activities 哈马药用植物:植物化学物质、传统用途和生物活性系统综述
Pub Date : 2023-03-24 DOI: 10.21448/ijsm.1132549
Chaima Benine, Ali Boutlelis Djahra, Laiche AMMAR TOUHAMİ, A. Rebiai
Medicinal plants have played an important influence in the development of human society; they were always at the forefront of all cultures and civilizations as a source of medicine. Medicinal plants are considered rich sources of secondary compounds, and many modern medications are derived from them. Hammada scoparia is a medicinal plant that belongs to the Chenopodiaceae family. It is currently found in North Africa (Morocco, Algeria, Libya, and Egypt) and has many medicinal properties used as folk medicine. The present research discusses the phytochemical components and biological activities of Hammada scoparia. The corresponding data were collected from various online databases, new research, and published resources. Different secondary compounds from the species have been documented, including flavonoids, tannins, alkaloids, terpenoids, and saponins. Pharmacological research has demonstrated that the major bioactives have antimicrobial, antioxidant, cytotoxic, and antimalarial activities and anticancer, reno-protective, and hepatoprotective effects. In conclusion, this study provides much information about the interests of vegetal species: Hammada scoparia.
药用植物在人类社会发展中发挥了重要作用;他们始终处于所有文化和文明的前沿,是医学的源泉。药用植物被认为是次生化合物的丰富来源,许多现代药物都是从中提取的。Hammada scoperia是藜科的一种药用植物。它目前在北非(摩洛哥、阿尔及利亚、利比亚和埃及)发现,具有许多用作民间药物的药用特性。本研究探讨了哈马的植物化学成分和生物学活性。相应的数据是从各种在线数据库、新研究和已发表的资源中收集的。已经记录了该物种的不同次生化合物,包括黄酮类化合物、单宁、生物碱、萜类化合物和皂苷。药理学研究表明,主要的生物活性物质具有抗菌、抗氧化、细胞毒性和抗疟活性,并具有抗癌、肾保护和肝保护作用。总之,本研究提供了许多关于植物物种兴趣的信息:Hammada scoparia。
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引用次数: 1
Oxidative stress induced by fluorine in Xanthoria parietina (L.) Th. Fr. 氟对黄原菌氧化应激的诱导作用。
Pub Date : 2023-03-23 DOI: 10.21448/ijsm.1136546
Ouahiba Benhamada, Nabila Benhamada, E. Leghouchi
In our work we were interested in the toxicity of fluorine on the various parameters of stress: chlorophyll, proteins, and antioxidant system in the lichen Xanthoria parietina (L.) Th. Fr., and for this purpose, lichen thalli were treated by sodium fluoride (NaF) at concentrations of 0, 0.5, 1.0, 5.0 and 10.0 mM, for time scale 0, 24, 48 and 96 h. The analysis results obtained revealed that all the parameters evaluated showed significant variations compared to those of the controls. From the analysis results obtained, it was noted that chlorophyll a (Ca), chlorophyll b (Cb) and total chlorophyll (Ca+b) decreased correlating with exposure times to NaF (r = -0.785, p < 0.001; r = -0.955, p < 0.001; r = -0.899, p < 0.001, respectively), with a significant increase of Ca/b ratio (p = 0.00572**) showing that Cb was more affected than Ca. However, hydrogen peroxide (H2O2) increased (r = 0.949, p < 0.001). In correlation with NaF concentrations, Glutathione (GSH) increased (r = 0.969, p < 0.001), while proteins decreased (r = -0.872, p < 0.001). Furthermore, results showed that catalase activity (CAT) increased correlating with increasing exposure time of X. parietina to increasing concentrations of NaF. Long-term exposure (48 h -96 h) caused a significant decrease in GSH content (p = 0.02*) followed by total destruction at time 96 h.
在我们的工作中,我们对氟对地衣叶绿素、蛋白质和抗氧化系统的各种胁迫参数的毒性感兴趣。Th。在0、0.5、1.0、5.0和10.0 mM浓度的氟化钠(NaF)处理地衣,时间尺度分别为0、24、48和96 h。分析结果表明,与对照组相比,所有参数均有显著差异。分析结果表明,叶绿素a (Ca)、叶绿素b (Cb)和总叶绿素(Ca+b)随NaF暴露时间的增加而降低(r = -0.785, p < 0.001);R = -0.955, p < 0.001;r = -0.899, p < 0.001), Ca/b比值显著升高(p = 0.00572**),表明Cb比Ca受影响更大,而过氧化氢(H2O2)升高(r = 0.949, p < 0.001)。与NaF浓度相关,谷胱甘肽(GSH)含量升高(r = 0.969, p < 0.001),蛋白质含量降低(r = -0.872, p < 0.001)。此外,过氧化氢酶活性(CAT)随NaF浓度的增加而增加。长期暴露(48 h -96 h)导致谷胱甘肽含量显著降低(p = 0.02*),随后在96 h发生完全破坏。
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引用次数: 0
Susceptibility of bacterial species isolated from mares to ozonated sunflower oil 从母马中分离的细菌对臭氧葵花油的敏感性
Pub Date : 2023-03-16 DOI: 10.21448/ijsm.1167867
Gabriel Souza dos Santos, Arthur Azevedo Perpétuo, Marcus Vinícius DİAS SOUZA
Sunflower oil is known for its therapeutic properties and culinary use. It is an important alimentary source of tocopherol and unsaturated fatty acids, and is used especially for wound healing. Studies on its antimicrobial potential, however, are lacking. The ozonation of oils of vegetable sources has been explored to enhance their therapeutic properties; however, studies that provide evidence of such benefits are still lacking. In the field of veterinary medicine, such data are even more scarce. In this study, the antimicrobial activity of ozonated sunflower oil was compared to that of non-ozonated oil, in an in vitro system, against strains of Staphylococcus aureus and Escherichia coli, isolated from intrauterine lavages of mares with endometritis. Tests were conducted using the minimum inhibitory concentration method. The ozonated oil was effective against S. aureus, whereas it was not against E. coli isolates. Our data open doors for discussion on the use of sunflower oil, with or without ozone treatment, for therapeutic purposes in veterinary medicine.
葵花籽油以其治疗特性和烹饪用途而闻名。它是生育酚和不饱和脂肪酸的重要食物来源,特别用于伤口愈合。然而,对其抗菌潜力的研究还很缺乏。探索了植物油的臭氧化处理,以提高其治疗性能;然而,提供这些益处的证据的研究仍然缺乏。在兽医学领域,这样的数据更是稀缺。在这项研究中,在体外系统中比较了臭氧化葵花籽油与非臭氧化葵花籽油对从子宫内膜炎母马宫内冲洗液中分离的金黄色葡萄球菌和大肠杆菌的抗菌活性。采用最小抑菌浓度法进行试验。臭氧化油对金黄色葡萄球菌有效,对大肠杆菌无效。我们的数据打开了讨论使用葵花籽油的大门,有或没有臭氧处理,用于兽医学的治疗目的。
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引用次数: 0
Assessment of genetic diversity based on agro-morphological traits and ISSR molecular markers in einkorn wheat (Triticum monococcum ssp. monococcum) landrace populations from Turkey 基于农业形态特征和ISSR分子标记的土耳其小麦地方品种群体遗传多样性评估
Pub Date : 2023-03-16 DOI: 10.21448/ijsm.1084853
Suliman Zommita, Gülgez Gökçe Yıldız, N. Zencirci, Ö. Özbek, Ömer Can Ünüvar, E. Ünlü
The aim of this study is to investigate genetic diversity in 48 einkorn (Triticum monococcum L. ssp. monococcum) landraces grown in agricultural areas of Bolu and Kastamonu. Therefore, variation in seven agro-morphological traits was investigated. Agro-morphological traits such as leaf weight (mg), coleoptile length (cm), root number (n), root length (cm), fresh root weight (mg), and dry root weight (mg) were examined by the coefficient of variation, ANOVA, and principal components analysis. The highest coefficient of variation (%) was observed in fresh root weight (FRW = 52.09%), while the lowest was in leaf weight (LW = 8.9%). Principal Component Analysis (PCA) was calculated as 76.93% variation in two main components. For molecular characterization, data obtained with iSSR primers were analyzed with the population genetics analysis program PopGene (ver. 1.32). According to PopGene results, the mean number of alleles, the mean number of effective alleles, and average genetic diversity values were calculated as na = 2, nea = 1.33, and h = 0.13, respectively. Among the agro-morphological traits, germination power, root number, and coleoptile length appeared to be reliable traits. The results show that the use of morphological characters alone for genetic diversity in populations is not sufficient to determine the difference between populations and their genetic structure.
本研究的目的是研究48个单粒小麦(Triticum monococum L. ssp)的遗传多样性。生长在Bolu和Kastamonu农业区的地方品种。因此,研究了7个农业形态性状的变异。采用变异系数、方差分析和主成分分析等方法对叶片重(mg)、胚芽鞘长(cm)、根数(n)、根长(cm)、鲜根重(mg)和干根重(mg)等农业形态性状进行检验。变异系数最大的是鲜根重(FRW = 52.09%),最小的是叶重(LW = 8.9%)。主成分分析(PCA)计算出两个主成分的变异率为76.93%。用iSSR引物获得的数据用群体遗传学分析程序PopGene (ver.)进行分子分析。1.32)。根据PopGene结果计算出平均等位基因数、平均有效等位基因数和平均遗传多样性值分别为na = 2、nea = 1.33、h = 0.13。在农业形态性状中,发芽率、根数和胚芽鞘长度是可靠的性状。结果表明,仅用形态特征来衡量群体的遗传多样性不足以确定群体之间及其遗传结构的差异。
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引用次数: 0
Interactive effects of salicylic acid and jasmonic acid on secondary metabolite production in Echinacea purpurea 水杨酸和茉莉酸对紫锥菊次生代谢产物产生的相互作用
Pub Date : 2023-03-16 DOI: 10.21448/ijsm.1079812
Fatemeh Rasoli̇, M. Gholipoor
Secondary metabolites are highly beneficial to human health and have commercial and industrial values. So, this research aimed to study the effects of exogenous salicylic acid (SA) and jasmonic acid (JA) on some secondary metabolites in purple coneflower. A field experiment as a randomized complete block design with three replications was conducted in Shahrood, Iran. Treatments were the factorial arrangement of 3 SA (0, 0.5, and 1 millimole) and 4 JA concentrations (0, 5, 20, and 50 micromole). The non-linear regression procedure was employed to quantify the relation of these materials with each other. The results indicated that the SA effect on all ten measured secondary metabolites changed with changing the JA levels as there was the interaction between these elicitors. On average, most (7 out of 11) of the combined SA_JA levels up-regulated the production of secondary metabolites as compared to the plants not sprayed with SA and JA. In terms of average response to elicitation with 11 combined SA_JA levels, they ranked from higher to lower as the guaiacol peroxidase, hydrogen proxide (H2O2), polyphenol oxidase, glutathione S-transferase, superoxide dismutase, NADPH oxidase, total phenolic content, phenylalanine ammonia-lyase, anthocyanin, and flavonoid. A few secondary metabolites appeared to have a biphasic relationship with each other. For instance, over lower and medium values of NADPH oxidase activity, anthocyanin content increased linearly with increasing NADPH oxidase activity; over higher values of NADPH oxidase activity, it showed a plateau state.
次生代谢物对人体健康非常有益,具有商业和工业价值。因此,本研究旨在研究外源水杨酸(SA)和茉莉酸(JA)对紫合花次生代谢产物的影响。在伊朗Shahrood进行了3个重复的随机完全区组田间试验。处理是3个SA(0、0.5和1毫摩尔)和4个JA浓度(0、5、20和50毫摩尔)的阶乘排列。采用非线性回归方法量化了这些材料之间的关系。结果表明,由于这些激发子之间存在相互作用,SA对所有10种次生代谢产物的影响都随着JA水平的变化而变化。平均而言,与未施用SA和JA的植株相比,大多数(7 / 11)SA_JA组合水平上调了次生代谢物的产量。11种组合SA_JA对诱导的平均响应从高到低依次为愈创木酚过氧化物酶、过氧化氢(H2O2)、多酚氧化酶、谷胱甘肽s -转移酶、超氧化物歧化酶、NADPH氧化酶、总酚含量、苯丙氨酸解氨酶、花青素、类黄酮。少数次生代谢物似乎彼此具有双相关系。例如,在低、中值NADPH氧化酶活性下,花青素含量随NADPH氧化酶活性的增加而线性增加;当NADPH氧化酶活性较高时,呈平台状态。
{"title":"Interactive effects of salicylic acid and jasmonic acid on secondary metabolite production in Echinacea purpurea","authors":"Fatemeh Rasoli̇, M. Gholipoor","doi":"10.21448/ijsm.1079812","DOIUrl":"https://doi.org/10.21448/ijsm.1079812","url":null,"abstract":"Secondary metabolites are highly beneficial to human health and have commercial and industrial values. So, this research aimed to study the effects of exogenous salicylic acid (SA) and jasmonic acid (JA) on some secondary metabolites in purple coneflower. A field experiment as a randomized complete block design with three replications was conducted in Shahrood, Iran. Treatments were the factorial arrangement of 3 SA (0, 0.5, and 1 millimole) and 4 JA concentrations (0, 5, 20, and 50 micromole). The non-linear regression procedure was employed to quantify the relation of these materials with each other. The results indicated that the SA effect on all ten measured secondary metabolites changed with changing the JA levels as there was the interaction between these elicitors. On average, most (7 out of 11) of the combined SA_JA levels up-regulated the production of secondary metabolites as compared to the plants not sprayed with SA and JA. In terms of average response to elicitation with 11 combined SA_JA levels, they ranked from higher to lower as the guaiacol peroxidase, hydrogen proxide (H2O2), polyphenol oxidase, glutathione S-transferase, superoxide dismutase, NADPH oxidase, total phenolic content, phenylalanine ammonia-lyase, anthocyanin, and flavonoid. A few secondary metabolites appeared to have a biphasic relationship with each other. For instance, over lower and medium values of NADPH oxidase activity, anthocyanin content increased linearly with increasing NADPH oxidase activity; over higher values of NADPH oxidase activity, it showed a plateau state.","PeriodicalId":14437,"journal":{"name":"International Journal of Secondary Metabolite","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-03-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48738480","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Analysis of phytochemical composition and biological activities of Helichrysum pallasii (Sprengel) ledeb leaves 黄蜡菊叶片的植物化学成分及生物活性分析
Pub Date : 2023-03-15 DOI: 10.21448/ijsm.1132698
Nejmi Işik, Muzaffer Mükemre, Rabia Sena Türker, G. Zengin, Abdullah Dalar
This study aimed at the investigation of in vitro biological activities (antioxidant and enzyme inhibition) and phytochemical composition of various extracts (ethanol maceration, aqueous infusion, and aqueous decoction) obtained from leaf organs of Helichrysum pallasii, which has been traditionally used as herbal tea and medicine in Eastern Anatolia.Experimental analysis showed that ethanol-based extract had higher total phenolic content (TPC: 103 mg GAE/gE) and showed superior antioxidant potentials (FRAP: 2205 μmol Fe2+/gE; ORAC: 2540 μmol Trolox Eq./gE; DPPH: IC50=0.58 mg/ml; CUPRAC: IC50=0.37 mg/ml; Phosphomolybdenum: IC50=1.34 mg/ml ve metal chelation: IC50=1.42 mg/ml) and enzyme inhibition (Acetylcholinesterase: IC50=1.49 mg/ml; Butyrylcholinesterase: IC50=1.98 mg/ml; Tyrosinase: IC50=0.68 mg/ml; Alpha-amylase: IC50=2.09 mg/ml; Alpha-glucosidase: IC50=0.51 mg/ml; and Pancreatic lipase: IC50=42.5 μg/ml) and contained higher amounts of phenolic (chlorogenic acid isomers and rutin) and fatty acid (palmitic, linoleic, and linolenic acids) compounds than traditional preparations (infusion and decoction). The current study's findings indicate that the leaves of the Helichrysum pallasii are a source of phytochemicals with strong antioxidant and enzyme inhibitory properties, implying that it could be a candidate for biotherapeutic agent research and development.
本研究旨在研究从蜡菊叶器官中提取的各种提取物(乙醇浸渍、水浸液和水煎液)的体外生物活性(抗氧化和酶抑制)和植物化学成分,实验分析表明,乙醇提取物具有较高的总酚含量(TPC:103 mg GAE/gE),并显示出优异的抗氧化潜力(FRAP:2205μmol Fe2+/gE;ORAC:2540μmol Trolox Eq./gE;DPPH:IC50=0.58 mg/ml;CUTRAC:IC50=0.37 mg/ml;磷钼:IC50=1.34 mg/ml ve金属螯合:IC50=1.42 mg/ml)和酶抑制(乙酰胆碱酯酶:IC50=1.49 mg/ml;丁酰胆碱酯酶:IC50:1.98 mg/ml;酪氨酸酶:IC50=0.68 mg/ml;α-淀粉酶:IC50=2.09 mg/ml;β-葡萄糖苷酶:IC50:0.51 mg/ml;胰脂肪酶:IC50=42.5μg/ml),与传统制剂相比,其酚类(绿原酸异构体和芦丁)和脂肪酸(棕榈酸、亚油酸和亚麻酸)化合物含量更高(输液和煎煮)。目前的研究结果表明,蜡菊的叶子是一种具有强大抗氧化和酶抑制特性的植物化学物质来源,这意味着它可能是生物治疗剂研发的候选者。
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引用次数: 1
Antioxidant activity, analgesic activity, and phytochemical analysis of Ammi majus (L.) extracts 麻仁提取物的抗氧化、镇痛活性及植物化学分析
Pub Date : 2023-03-14 DOI: 10.21448/ijsm.1139246
O. El-Guourrami, Soufiane Drioua, Mouna Ameggouz, N. Salhi, K. Sayah, G. Zengin, Ahmed Zahidi, A. Doukkali, H. Benzeid
Ammi majus (L.) is commonly used to cure many diseases in Moroccan folk medicine, especially vitiligo. This research tries to evaluate the phytochemical constituents of two aqueous extracts (E1; Maceration; 48 h) and (E2: Infusion; 1h) and three organic fractions (F1: Cyclohexane), (F2: Ethyl acetate (EtOAc)) and (F3: Ethanolic (EtOH)) of A. majus (L.) seeds, as well as to study the antioxidant and analgesic activity of the species. Phytochemical analysis, antioxidant activity (DPPH, FRAP, ABTS, and TAC tests), and analgesic activity (writhing and tail immersion were induced by Acetic acid tests) were analyzed according to the literature. A quantitative phytochemical study indicate that the E1 had the highest content of total polyphenols (26.95 ± 0.53 mg GAE/g extract) and flavonoids (37.92 ± 0.46 mg QE/g extract), while F3 showed a promising flavonol content (24.26±0.08 mg QE/g extract). Tannins were found to be high in F1 (59.27 ± 0.16 mg CE/g extract) and F2 (57.65 ± 1.18 mg CE/g extract). Antioxidant results reveals that DPPH (IC50 = 179.68 ± 0.47 μg/mL) and FRAP (EC50 = 367.03 ± 0.12 μg/mL) show to E1 a high antioxidant activity. Regarding the analgesic activity of the different studied extracts, it was found that E1 has a high peripheral analgesic effect with 62.32 % and a high central analgesic potential throughout the experimentation at 500 mg/kg. Our studies demonstrated for the first time that A. majus seeds extracts have high antioxidant and analgesic activities through different analysis techniques.
在摩洛哥民间医学中,阿米马朱斯(Ammi majus,L.)常用于治疗许多疾病,尤其是白癜风。本研究试图评价马齿苋种子的两种水提取物(E1;浸泡;48小时)和(E2:浸泡;1小时)以及三种有机组分(F1:环己烷)、(F2:乙酸乙酯(EtOAc))和(F3:乙醇(EtOH))的植物化学成分,并研究其抗氧化和镇痛活性。根据文献分析了植物化学分析、抗氧化活性(DPPH、FRAP、ABTS和TAC试验)和镇痛活性(醋酸试验诱导扭体和尾部浸泡)。定量植物化学研究表明,E1的总多酚含量最高(26.95±0.53 mg GAE/g提取物),黄酮含量最高(37.92±0.46 mg QE/g提取物),而F3的黄酮醇含量很有希望(24.26±0.08 mg QE/g提取液)。F1(59.27±0.16mg CE/g提取物)和F2(57.65±1.18mg CE/g提取液)中的单宁含量较高。抗氧化结果表明,DPPH(IC50=179.68±0.47μg/mL)和FRAP(EC50=367.03±0.12μg/mL。关于所研究的不同提取物的镇痛活性,发现E1在500mg/kg的整个实验中具有62.32%的高外周镇痛作用和高中枢镇痛潜力。我们的研究首次表明,通过不同的分析技术,马齿苋种子提取物具有较高的抗氧化和镇痛活性。
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引用次数: 1
Promising antioxidant activity of crude extract from Calliandra tweedii Benth 杜鹃花粗提物抗氧化活性研究
Pub Date : 2023-03-06 DOI: 10.21448/ijsm.953427
Kátia Pereira dos Santos, Alice Nagai, Carmen E. Palacios, Bruno Evangelista, Carlos Pri̇ante, Débora Zamban, C. Furlan
The interest in medicinal plants encourages new research studies on plant extracts, as they are sources for treatments in medicine, agriculture, and veterinary. Calliandra tweedii is a native Brazilian species with broad use in folk medicine. This study aimed to examine the leaf crude extract (CE) of C. tweedii and its methanolic (MP) and hexane (HP) phases concerning total phenolic compounds (TPC), proanthocyanidins (PRO), and flavonoid profile, and correlate it to their antioxidant activity (DPPH and FRAP). CE and MP revealed high contents of TPC, PRO and high antioxidant activity (DPPH and FRAP) in relation to HP. Opposite, HP showed reduced antioxidant activity, according to the scarce phenolic constituents obtained from the partition. Five flavonols were detected by HPLC-UV-DAD, being quercitrin the major constituent. Also, one kaempferol derivate, and a series of three quercetin derivates were detected. Strong positive correlations were observed between DPPH, FRAP, and phenolic compounds. These discoveries are important to highlight the promising antioxidant activity of CE of C. tweedii, which could contribute to the expansion of popular herbal medicines and new drug discovery.
对药用植物的兴趣鼓励了对植物提取物的新研究,因为它们是医学、农业和兽医治疗的来源。特威迪卡利安德拉是一种巴西本土物种,在民间医学中有着广泛的用途。本研究旨在检测粗花叶提取物(CE)及其甲醇(MP)和己烷(HP)相的总酚类化合物(TPC)、原花青素(PRO)和类黄酮含量,并将其与抗氧化活性(DPPH和FRAP)联系起来。CE和MP显示与HP相关的TPC、PRO含量高和抗氧化活性高(DPPH和FRAP)。相反,根据从分配中获得的稀缺酚类成分,HP显示出降低的抗氧化活性。用HPLC-UV-DAD法检测了5种黄酮醇,其中槲皮素为主要成分。此外,还检测到一种山奈酚衍生物和一系列三种槲皮素衍生物。DPPH、FRAP和酚类化合物之间存在很强的正相关性。这些发现对于突出粗花C.tweedii CE的抗氧化活性具有重要意义,这可能有助于扩大流行草药和新药的发现。
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引用次数: 0
In vitro investigations of biological activities of Thymus willdenowii and Thymus atlanticus polyphenol-rich extracts willdenowii和atlanticus富含多酚提取物的体外生物活性研究
Pub Date : 2023-03-05 DOI: 10.21448/ijsm.1110715
Elbouny Hamza, Ouahzizi Brahi̇m, S. Khalid, Alem Chakib
Thyme species produce a wide variety of phenolic compounds including tannins, phenolic acids, and flavonoids. Thymus atlanticus (T. atlanticus) and Thymus willdenowii (T. willdenowii) are important thyme species in the southeast of Morocco, with numerous biological properties. The polyphenolic extracts of these two thyme species were obtained using ethanol through Soxhlet apparatus. Antioxidant (DPPH, FRAP, and TAC methods), antihemolytic (2,2'-Azobis(2-amidinopropane) dihydrochloride (AAPH) induced hemolysis test), hypolipidemic (3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase activity inhibition test), and anti-inflammatory (protein denaturation inhibition) effects of extracts were carried out using in vitro methods. The results showed that the polyphenolic extracts of these two species revealed important amounts of phenolic compounds. The contents of flavonoids were significant in the two species, while the contents of tannins and anthocyanin were very low. T. atlanticus showed an important antioxidant activity and a considerable antihemolytic effect in AAPH-induced hemolysis test (IC50 = 0.29 mg/mL), while T. willdenowii showed an important anti-inflammatory activity in heat-induced protein denaturation test (IC50 = 1.61 mg/mL). Moreover, both extracts at a dose of 20 µg/mL showed an important in vitro hypolipidemic activity by inhibiting HMG-CoA reductase activity (T. willdenowii: 51.16 %; T. atlanticus: 62.83 %). In conclusion, T. willdenowii and T. atlanticus extracts have considerable antioxidant, antihemolytic, hypolipidemic, and anti-inflammatory effects. The richness of these species in polyphenols gives them a large specter of biological properties, making them a valuable source of natural bioactive compounds that could prevent or treat various diseases.
百里香产生多种酚类化合物,包括单宁、酚酸和黄酮类化合物。atlanticus和willdenowii是摩洛哥东南部的重要百里香物种,具有许多生物学特性。这两种百里香的多酚提取物是用乙醇通过索氏装置获得的。使用体外方法进行提取物的抗氧化(DPPH、FRAP和TAC方法)、抗溶血(2,2'-偶氮双(2-氨基丙烷)二盐酸盐(AAPH)诱导的溶血试验)、降血脂(3-羟基-3-甲基戊二酰辅酶A(HMG-CoA)还原酶活性抑制试验)和抗炎(蛋白质变性抑制)作用。结果表明,这两种植物的多酚提取物中含有大量的酚类化合物。两种植物中黄酮类化合物含量显著,而单宁和花青素含量极低。atlanticus在AAPH诱导的溶血试验中显示出重要的抗氧化活性和相当大的抗溶血作用(IC50=0.29 mg/mL),而willdenowii在热诱导的蛋白质变性试验中表现出重要的抗炎活性(IC50=1.61 mg/mL)。此外,两种提取物在20µg/mL的剂量下均通过抑制HMG-CoA还原酶活性显示出重要的体外降血脂活性(T.willdenwii:51.16%;T.atlanticus:62.83%)。总之,willdenowii和T.atlanticus提取物具有相当大的抗氧化、解热、降血脂和抗炎作用。这些物种富含多酚,这使它们具有很大的生物特性,成为预防或治疗各种疾病的天然生物活性化合物的宝贵来源。
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引用次数: 2
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International Journal of Secondary Metabolite
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