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Human Papillomavirus-Associated Oral Epithelial Dysplasia: A Practical Approach to Make the Diagnosis. 人类乳头瘤病毒相关口腔上皮增生症:诊断的实用方法》(Human Papillomavirus-Associated Oral Epithelial Dysplasia: A Practical Approach to Make the Diagnosis)。
IF 2.4 Q2 MEDICINE, GENERAL & INTERNAL Pub Date : 2024-03-01 DOI: 10.30476/IJMS.2023.96202.2897
Kiarash Parchami, Samira Derakhshan, Hana Saffar, Pouyan Aminishakib, Ahmad Reza Shamshiri, Samaneh Afshar

Background: High-risk Human Papillomavirus (HPV) genotypes are found in malignant oral epithelial lesions, and HPV infection is proposed as a risk factor for initiating Squamous cell carcinoma (SCC) in the head and neck region. This study suggests a practical approach to detect HPV in HPV-associated oral epithelial dysplasia (HAOED).

Methods: Fifty-four oral epithelial dysplasia specimens were examined, comprising twenty-seven cases diagnosed with high-grade dysplasia and twenty-seven cases diagnosed with low-grade dysplasia using a binary grading system. To assess the cases for HPV, the specimens were examined for p16 protein using an immunohistochemical (IHC) study, and then, the Chromatin In Situ Hybridization (CISH) test was performed for all positive cases. Chromatin Immunoprecipitation-Polymerase Chain Reaction (ChIP-PCR) was performed on CISH-positive specimens to assess the outcome. This cross-sectional study was conducted in 2020 at Tehran University of Medical Science. SPSS software version 22.0 was used to perform the Chi square or Fisher's exact test to examine the relationship between variables (statistically significant level P<0.05).

Results: The expression of p16 protein was not associated with the severity of epithelial dysplasia (81.5% in low-grade and 59.2% in high-grade cases) (P=0.16). Moreover, according to the CISH test result, 9.25% of all specimens were positive (P>0.99), and in the nine cases, undergone the ChIP-PCR study, two cases (22.2%) showed positivity for HPV-16, while one case (11.1%) demonstrated positivity for HPV-51.

Conclusion: Regarding HAOED, here, we proposed a step-by-step combination approach using different diagnostic methods, including IHC for p16 protein, CISH, and ChIP-PCR based on a complementary algorithm.

背景:在恶性口腔上皮病变中发现了高危人乳头瘤病毒(HPV)基因型,HPV感染被认为是引发头颈部鳞状细胞癌(SCC)的危险因素。本研究提出了一种检测 HPV 相关口腔上皮发育不良(HAOED)中 HPV 的实用方法:方法:采用二元分级系统检查了54例口腔上皮发育不良标本,其中27例被诊断为高级别发育不良,27例被诊断为低级别发育不良。为了评估病例是否感染了人乳头瘤病毒,研究人员对标本进行了免疫组化(IHC)检查,以检测 p16 蛋白,然后对所有阳性病例进行了染色质原位杂交(CISH)检测。对 CISH 阳性标本进行染色质免疫沉淀聚合酶链反应(ChIP-PCR),以评估结果。这项横断面研究于 2020 年在德黑兰医科大学进行。研究人员使用 SPSS 软件 22.0 版进行了卡方检验或费雪精确检验,以检验变量之间的关系(统计学显著水平):p16 蛋白的表达与上皮发育不良的严重程度无关(低度病例为 81.5%,高度病例为 59.2%)(P=0.16)。此外,根据 CISH 检测结果,9.25% 的标本呈阳性(P>0.99),在进行 ChIP-PCR 研究的 9 例病例中,2 例(22.2%)显示 HPV-16 阳性,1 例(11.1%)显示 HPV-51 阳性:关于 HAOED,我们在此提出了一种基于互补算法的分步组合方法,使用不同的诊断方法,包括 p16 蛋白 IHC、CISH 和 ChIP-PCR。
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引用次数: 0
The Potential Role of Autophagy in Progression of Liver Fibrosis in Chronic Hepatitis B Patients Receiving Antiviral Treatment: A Brief Report. 自噬在接受抗病毒治疗的慢性乙型肝炎患者肝纤维化进展中的潜在作用:简要报告。
IF 2.4 Q2 MEDICINE, GENERAL & INTERNAL Pub Date : 2024-03-01 DOI: 10.30476/ijms.2023.96588.2813
Kamran Bagheri Lankarani, Atefeh Sadidoost, Mohammadreza Fattahi, Saeid Amirizadeh Fard, Pooneh Mokarram

Despite antiviral treatment, some patients with chronic hepatitis B (CHB) progress to cirrhosis. Enhancement of autophagy was implicated in the proliferation of hepatitis B in hepatocytes. This study aimed to evaluate the potential role of autophagy in the progression of liver fibrosis in patients receiving antiviral treatments and having completely inhibited viral replication. This descriptive-analytical study was designed and conducted in 2020 at Mottahhari Hepatitis Clinic affiliated with Shiraz University of Medical Science (Shiraz, Iran). Patients who were on anti-hepatitis B nucleotide treatments for at least two years, and those who were not cirrhotic at baseline but later progressed to cirrhosis were identified to be included in the case group. Besides, for the control group, patients on the nucleotide regimens who did not have cirrhosis at baseline or during follow-up were randomly selected. Ultimately, 16 cases and 14 controls were included in the study. Data were analyzed using SPSS software, and P<0.05 was considered statistically significant. Serum Beclin-1 and LC3 levels were compared between the two groups using enzyme-linked immunosorbent assays. The t test was used to assess the statistical differences between the case and control groups. Beclin-1 level was significantly higher in cirrhosis patients than the control group (1283±244 vs. 1063±257, P=0.024). However, there was no statistical difference between the level of LC3 in the cirrhotic group (168±31) and the control group (150±16) (P=0.065). Autophagy may have a role in the progression of cirrhosis in patients with CHB. Future larger prospective studies are required to determine the effect of blocking on the progression of liver disease in this population A preprint of this study was published at https://www.researchsquare.com/article/rs-1435490/v1.pdf.

尽管接受了抗病毒治疗,一些慢性乙型肝炎(CHB)患者仍会发展为肝硬化。自噬的增强与乙型肝炎在肝细胞中的增殖有关。本研究旨在评估自噬在接受抗病毒治疗并完全抑制病毒复制的患者肝纤维化进展过程中的潜在作用。这项描述性分析研究于 2020 年在伊朗设拉子医科大学附属 Mottahhari 肝炎诊所(伊朗设拉子)设计和实施。病例组包括接受抗乙型肝炎核苷酸治疗至少两年的患者,以及基线时未患肝硬化但后来发展为肝硬化的患者。此外,在对照组中,随机选取了接受核苷酸治疗但在基线或随访期间未出现肝硬化的患者。研究最终纳入了 16 例病例和 14 例对照。研究使用 SPSS 软件对数据进行分析,并使用 Pt 检验来评估病例组和对照组之间的统计学差异。肝硬化患者的Beclin-1水平明显高于对照组(1283±244 vs. 1063±257,P=0.024)。然而,肝硬化组(168±31)和对照组(150±16)的 LC3 水平无统计学差异(P=0.065)。自噬可能在慢性乙型肝炎患者肝硬化的进展过程中发挥作用。未来需要进行更大规模的前瞻性研究,以确定阻断对该人群肝病进展的影响。本研究的预印本发表于 https://www.researchsquare.com/article/rs-1435490/v1.pdf。
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引用次数: 0
Mesenteric Panniculitis: An Enigma. 肠系膜泛发炎:一个谜。
IF 2.4 Q2 MEDICINE, GENERAL & INTERNAL Pub Date : 2024-03-01 DOI: 10.30476/IJMS.2023.98397.3074
Amit Kumar Gupta, Niraj Shrivastava
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引用次数: 0
Comparison of High-intensity Laser Therapy with Extracorporeal Shock Wave Therapy in the Treatment of Patients with Plantar Fasciitis: A Double-blind Randomized Clinical Trial. 高强度激光疗法与体外冲击波疗法在治疗足底筋膜炎患者方面的比较:双盲随机临床试验。
IF 2.4 Q2 MEDICINE, GENERAL & INTERNAL Pub Date : 2024-03-01 DOI: 10.30476/IJMS.2023.98042.2991
Marzieh Zare Bidoki, Mohammad Reza Vafaeei Nasab, Amidodin Khatibi Aghda

Background: The most common cause of heel pain is plantar fasciitis (PF). Although conservative treatments relieve pain in more than 90% of patients, it may remain painful in some cases. This study aimed to compare High-intensity Laser Therapy (HILT) with Extracorporeal Shock Wave Therapy (ESWT) in patients with PF.

Methods: In this double-blinded randomized clinical trial (conducted in Yazd, Iran, from May 2020 to March 2021), patients were classified into two groups, including the ESWT and HILT, using online randomization. Nine sessions, three times a week for 3 weeks, were the treatment period in both groups. Visual Analogue Score (VAS), Heel Tenderness Index (HTI), and the SF36 questionnaire were compared and analyzed statistically at the beginning and 9 months after treatment.

Results: 38 patients (19 in each group) completed the study. Results showed that pain and patient satisfaction improved significantly 3 months after treatment. The VAS and HTI decreased 3 months after treatment in both groups, which was statistically significant (P<0.001). The SF36 score in both groups increased 3 months after treatment, and this increase was statistically significant (P<0.001). Although the two modalities were effective based on VAS, HTI, and SF36, a significant statistical difference was observed between them (P=0.03, P=0.006, P=0.002, respectively), and the HILT was more effective.

Conclusion: ESWT and HILT decrease pain and increase patient satisfaction in PF. Besides, both methods are non-invasive and safe. However, there is a significant difference between them, and HILT is more effective. Trial registration number: IRCT20210913052465N1.

背景:足跟疼痛最常见的原因是足底筋膜炎(PF)。尽管保守治疗可缓解 90% 以上患者的疼痛,但在某些病例中,疼痛仍会持续。本研究旨在比较高强度激光疗法(HILT)和体外冲击波疗法(ESWT)对足跟炎患者的治疗效果:在这项双盲随机临床试验(2020 年 5 月至 2021 年 3 月在伊朗亚兹德进行)中,采用在线随机分配法将患者分为两组,包括 ESWT 组和 HILT 组。两组的治疗时间均为 9 次,每周 3 次,每次 3 周。对治疗开始时和治疗后 9 个月的视觉模拟评分(VAS)、足跟触痛指数(HTI)和 SF36 问卷进行比较和统计分析:38名患者(每组19人)完成了研究。结果显示,治疗 3 个月后,疼痛和患者满意度明显改善。两组患者在治疗 3 个月后的 VAS 和 HTI 均有所下降,具有统计学意义(PC 结论:ESWT 和 HILT 可降低患者的疼痛和满意度:ESWT 和 HILT 可以减轻 PF 患者的疼痛,提高患者满意度。此外,这两种方法都是非侵入性和安全的。但两者之间存在明显差异,HILT更为有效。试验注册号:IRCT20210913052465N1。
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引用次数: 0
Effect of Fish-Based Diet on Malnourished Children: A Systematic Review. 鱼类膳食对营养不良儿童的影响:系统回顾。
IF 2.4 Q2 MEDICINE, GENERAL & INTERNAL Pub Date : 2024-03-01 DOI: 10.30476/ijms.2023.96986.2863
La Banudi La Banudi, Purnomo Leksono, M Anas Anasiru

Background: Malnutrition in children is mainly caused by the lack of protein and fat intake which harms their ability to grow and survive. Accurate data on the benefits of fish-based foods on the nutritional status of children is limited. The present systematic review aimed to provide an overview of published articles on the nutritional value of fish-based foods for children.

Methods: A systematic review was performed during 2000-2021 by searching Science Direct, Cochrane Library, PubMed, ProQuest, and Wiley Online Library databases. The full text of selected articles in English was screened based on the inclusion and exclusion criteria. Included articles were all experimental studies (randomized control trial, quasi-randomized trial) or mixed methods studies involving malnourished children. The study was reported under the preferred reporting items for systematic reviews and meta-analyses guidelines. The risk of bias was assessed using the Cochrane tool.

Results: A total of 330,859 articles were screened, out of which eight articles were included in the systematic review. Interventions included fish-based foods and beverages such as wafer bars, Jemawut-tuna cookies, Amizate in chocolate drink, dried fish powder, flaxseed oil supplemented with fish oil capsules, and porridge fortified with fish powder. Primary or secondary outcomes were the determination of zinc level, height growth, erythrocyte n-3 polyunsaturated fatty acid content, safety and acceptability, intestinal integrity, and cognitive development. The results showed that dried fish powder produced the most significant effect on body weight.

Conclusion: The consumption of dried fish powder had positive effects on the recovery of malnourished children.

背景:儿童营养不良的主要原因是蛋白质和脂肪摄入不足,这损害了他们的生长和生存能力。有关鱼类食品对儿童营养状况益处的准确数据十分有限。本系统综述旨在概述已发表的有关儿童鱼类食品营养价值的文章:方法:在 2000-2021 年期间,通过搜索 Science Direct、Cochrane Library、PubMed、ProQuest 和 Wiley Online Library 数据库,进行了一次系统性综述。根据纳入和排除标准对所选英文文章的全文进行了筛选。纳入的文章均为涉及营养不良儿童的实验研究(随机对照试验、准随机试验)或混合方法研究。研究按照系统综述和荟萃分析指南的首选报告项目进行报告。使用 Cochrane 工具评估偏倚风险:共筛选出 330,859 篇文章,其中 8 篇文章被纳入系统综述。干预措施包括鱼类食品和饮料,如威化饼、Jemawut-tuna 饼干、巧克力饮料中的 Amizate、干鱼粉、亚麻籽油补充鱼油胶囊和强化鱼粉粥。主要或次要结果是测定锌水平、身高增长、红细胞中 n-3 多不饱和脂肪酸含量、安全性和可接受性、肠道完整性以及认知发展。结果显示,鱼干粉对体重的影响最为显著:结论:食用鱼干粉对营养不良儿童的康复有积极作用。
{"title":"Effect of Fish-Based Diet on Malnourished Children: A Systematic Review.","authors":"La Banudi La Banudi, Purnomo Leksono, M Anas Anasiru","doi":"10.30476/ijms.2023.96986.2863","DOIUrl":"https://doi.org/10.30476/ijms.2023.96986.2863","url":null,"abstract":"<p><strong>Background: </strong>Malnutrition in children is mainly caused by the lack of protein and fat intake which harms their ability to grow and survive. Accurate data on the benefits of fish-based foods on the nutritional status of children is limited. The present systematic review aimed to provide an overview of published articles on the nutritional value of fish-based foods for children.</p><p><strong>Methods: </strong>A systematic review was performed during 2000-2021 by searching Science Direct, Cochrane Library, PubMed, ProQuest, and Wiley Online Library databases. The full text of selected articles in English was screened based on the inclusion and exclusion criteria. Included articles were all experimental studies (randomized control trial, quasi-randomized trial) or mixed methods studies involving malnourished children. The study was reported under the preferred reporting items for systematic reviews and meta-analyses guidelines. The risk of bias was assessed using the Cochrane tool.</p><p><strong>Results: </strong>A total of 330,859 articles were screened, out of which eight articles were included in the systematic review. Interventions included fish-based foods and beverages such as wafer bars, Jemawut-tuna cookies, Amizate in chocolate drink, dried fish powder, flaxseed oil supplemented with fish oil capsules, and porridge fortified with fish powder. Primary or secondary outcomes were the determination of zinc level, height growth, erythrocyte n-3 polyunsaturated fatty acid content, safety and acceptability, intestinal integrity, and cognitive development. The results showed that dried fish powder produced the most significant effect on body weight.</p><p><strong>Conclusion: </strong>The consumption of dried fish powder had positive effects on the recovery of malnourished children.</p>","PeriodicalId":14510,"journal":{"name":"Iranian Journal of Medical Sciences","volume":"49 3","pages":"137-146"},"PeriodicalIF":2.4,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10997854/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140849532","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Correlation of US-7 and US-9 Scores with Disease Activity Score using 28 Joint Counts (DAS28) in Patients with Rheumatoid Arthritis. 类风湿关节炎患者 US-7 和 US-9 评分与使用 28 个关节计数的疾病活动度评分 (DAS28) 的相关性。
IF 2.4 Q2 MEDICINE, GENERAL & INTERNAL Pub Date : 2024-03-01 DOI: 10.30476/IJMS.2023.97776.2996
Sahar Ebadati, Maryam Sahebari, Amir Mahmoud Ahmadzadeh, Maryam Emadzadeh, Farzaneh Khoroushi, Hedieh Ragati Haghi, Ramesh Giti, Behzad Aminzadeh

Background: The attentive management of rheumatoid arthritis (RA) has attracted particular attention. The German 7-joint Ultrasound (US-7) is the first scoring system that combines bone erosions and soft tissue lesions in a single composite scoring system. This study aimed to assess the correlation between US-7 and Disease Activity Score Using 28 Joint Counts (DAS28) in clinically active RA patients. The efficacy of a novel ultrasound score-based system, the US-9 score (joints assessed with US-7 plus knees), was also compared with the standard US-7 score.

Methods: All the RA patients referred to the outpatient rheumatology clinic of Ghaem Hospital, Mashhad, Iran, during 2019-2020 were included. 28 joints were clinically examined to calculate DAS28. Nine joints were assessed comprising the German US-7 plus knees using grayscale ultrasonography (GSUS) and power Doppler ultrasonography (PDUS). Retrieved data were analyzed by SPSS software, version 22. The Spearman Correlation test was used to find the correlation between DAS28 and ultrasonographic findings. The statistical significance level was set at P<0.05.

Results: This study was composed of thirty-five RA patients with a mean age of 49.1±12.0 years. US-7 synovitis scores in GSUS and PDUS were significantly correlated with DAS28 (P=0.02, r=0.38 and P=0.003, r=0.48, respectively). US-9 synovitis scores in GSUS and PDUS were also significantly correlated with DAS28 (P=0.003, r=0.49 and P=0.006, r=0.45, respectively). The synovitis score measured by GSUS was significantly correlated with the GSUS knee synovial score (P=0.01, r=0.42).

Conclusion: Ultrasound assessment of large joints such as knees can be an effective approach to determining RA severity. However, it can be proposed that adding more involved joints into the sonographic assessment does not necessarily provide a better clinical correlation.

背景:类风湿性关节炎(RA)的贴心管理尤其引人关注。德国七关节超声(US-7)是首个将骨侵蚀和软组织病变纳入单一综合评分系统的评分系统。本研究旨在评估临床活跃的 RA 患者的 US-7 与使用 28 个关节计数的疾病活动度评分(DAS28)之间的相关性。此外,还比较了基于超声评分的新型系统 US-9 评分(US-7 加膝关节评估)与标准 US-7 评分的效果:方法:纳入2019-2020年期间转诊至伊朗马什哈德市盖姆医院风湿病门诊的所有RA患者。对 28 个关节进行临床检查,计算 DAS28。使用灰阶超声波(GSUS)和功率多普勒超声波(PDUS)评估了九个关节,包括德国 US-7 加膝盖。检索到的数据由 SPSS 软件(22 版)进行分析。斯皮尔曼相关性检验用于发现 DAS28 与超声波检查结果之间的相关性。统计显著性水平设定为 PResults:本研究由 35 名 RA 患者组成,平均年龄(49.1±12.0)岁。GSUS 和 PDUS 的 US-7 滑膜炎评分与 DAS28 显著相关(分别为 P=0.02,r=0.38 和 P=0.003,r=0.48)。GSUS 和 PDUS 的 US-9 滑膜炎评分与 DAS28 也有明显相关性(分别为 P=0.003,r=0.49 和 P=0.006,r=0.45)。GSUS测量的滑膜炎评分与GSUS膝关节滑膜评分有明显相关性(P=0.01,r=0.42):结论:对膝关节等大关节进行超声评估是确定 RA 严重程度的有效方法。结论:超声评估膝关节等大关节可作为判断 RA 严重程度的有效方法,但超声评估中增加受累关节并不一定能提供更好的临床相关性。
{"title":"Correlation of US-7 and US-9 Scores with Disease Activity Score using 28 Joint Counts (DAS28) in Patients with Rheumatoid Arthritis.","authors":"Sahar Ebadati, Maryam Sahebari, Amir Mahmoud Ahmadzadeh, Maryam Emadzadeh, Farzaneh Khoroushi, Hedieh Ragati Haghi, Ramesh Giti, Behzad Aminzadeh","doi":"10.30476/IJMS.2023.97776.2996","DOIUrl":"https://doi.org/10.30476/IJMS.2023.97776.2996","url":null,"abstract":"<p><strong>Background: </strong>The attentive management of rheumatoid arthritis (RA) has attracted particular attention. The German 7-joint Ultrasound (US-7) is the first scoring system that combines bone erosions and soft tissue lesions in a single composite scoring system. This study aimed to assess the correlation between US-7 and Disease Activity Score Using 28 Joint Counts (DAS28) in clinically active RA patients. The efficacy of a novel ultrasound score-based system, the US-9 score (joints assessed with US-7 plus knees), was also compared with the standard US-7 score.</p><p><strong>Methods: </strong>All the RA patients referred to the outpatient rheumatology clinic of Ghaem Hospital, Mashhad, Iran, during 2019-2020 were included. 28 joints were clinically examined to calculate DAS28. Nine joints were assessed comprising the German US-7 plus knees using grayscale ultrasonography (GSUS) and power Doppler ultrasonography (PDUS). Retrieved data were analyzed by SPSS software, version 22. The Spearman Correlation test was used to find the correlation between DAS28 and ultrasonographic findings. The statistical significance level was set at P<0.05.</p><p><strong>Results: </strong>This study was composed of thirty-five RA patients with a mean age of 49.1±12.0 years. US-7 synovitis scores in GSUS and PDUS were significantly correlated with DAS28 (P=0.02, r=0.38 and P=0.003, r=0.48, respectively). US-9 synovitis scores in GSUS and PDUS were also significantly correlated with DAS28 (P=0.003, r=0.49 and P=0.006, r=0.45, respectively). The synovitis score measured by GSUS was significantly correlated with the GSUS knee synovial score (P=0.01, r=0.42).</p><p><strong>Conclusion: </strong>Ultrasound assessment of large joints such as knees can be an effective approach to determining RA severity. However, it can be proposed that adding more involved joints into the sonographic assessment does not necessarily provide a better clinical correlation.</p>","PeriodicalId":14510,"journal":{"name":"Iranian Journal of Medical Sciences","volume":"49 3","pages":"167-175"},"PeriodicalIF":2.4,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10997851/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140858536","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Adipose-Derived Stem Cells' Secretome Attenuates Lesion Size and Parasite Loading in Leishmaniasis Caused by Leishmania Major in Mice. 脂肪干细胞的分泌物减轻小鼠利什曼病的皮损面积和寄生虫负荷
IF 2.4 Q2 MEDICINE, GENERAL & INTERNAL Pub Date : 2024-02-01 DOI: 10.30476/IJMS.2023.96413.2795
Iman Khodkar, Jasem Saki, Reza Arjmand, Ghasem Saki, Layasadat Khorsandi

Background: Stem cell-derived secretome (SE) released into the extracellular space contributes to tissue repair. The present study aimed to investigate the impact of isolated secretome (SE) from adipose-derived mesenchymal stem cells (ASCs) on Leishmania major (L. major) lesions in BALB/c mice.

Methods: This experimental study was conducted at Ahvaz University of Medical Sciences (Ahvaz, Iran) in 2021. Forty female BALB/c mice were infected with stationary phase promastigotes through intradermal injection in the bottom of their tail and randomly divided into four groups (n=10 per group). The mice were given SE (20 mg/mL), either alone or in combination with Glucantime (GC, 20 mg/mL/Kg), meglumine antimoniate (20 mg/mL/Kg) for the GC group, and phosphate-buffered saline (PBS) for the control group. After eight weeks, the lesion size, histopathology, the levels of Interleukin 10 (IL-10), and Interleukin 12 (IL-12) were assessed. For the comparison of values between groups, the parametric one-way ANOVA was used to assess statistical significance.

Results: At the end of the experiment, the mice that received SE had smaller lesions (4.56±0.83 mm versus 3.62±0.59 mm, P=0.092), lower levels of IL-10 (66.5±9.7 pg/mL versus 285.4±25.2 pg/mL, P<0.001), and higher levels of IL-12 (152.2±14.2 pg/mL versus 24.2±4.4 pg/mL, P<0.001) than the control. Histopathology findings revealed that mice treated with SE had a lower parasite burden in lesions and spleen than the control group.

Conclusion: The current study demonstrated that ADSC-derived SE could protect mice infected with L. major against leishmaniasis.

背景:干细胞衍生的分泌物(SE)释放到细胞外空间有助于组织修复。本研究旨在调查从脂肪间充质干细胞(ASCs)中分离出的分泌物对 BALB/c 小鼠利什曼原虫(L. major)病变的影响:这项实验研究于 2021 年在阿瓦士医科大学(伊朗阿瓦士)进行。40 只雌性 BALB/c 小鼠通过尾底部皮内注射感染了静止期原体,并随机分为四组(每组 10 只)。给小鼠单独注射 SE(20 毫克/毫升)或与 Glucantime(GC,20 毫克/毫升/千克)联合注射,GC 组注射甲氧苄啶(20 毫克/毫升/千克),对照组注射磷酸盐缓冲盐水(PBS)。八周后,对病变大小、组织病理学、白细胞介素 10(IL-10)和白细胞介素 12(IL-12)的水平进行评估。组间数值比较采用参数单因素方差分析,以评估统计学意义:结果:实验结束时,接受SE治疗的小鼠皮损更小(4.56±0.83 mm对3.62±0.59 mm,P=0.092),IL-10水平更低(66.5±9.7 pg/mL 对285.4±25.2 pg/mL,PC结论:目前的研究表明,ADSC衍生的SE可以保护感染大鼠的小鼠免受利什曼病的侵袭。
{"title":"Adipose-Derived Stem Cells' Secretome Attenuates Lesion Size and Parasite Loading in Leishmaniasis Caused by <i>Leishmania Major</i> in Mice.","authors":"Iman Khodkar, Jasem Saki, Reza Arjmand, Ghasem Saki, Layasadat Khorsandi","doi":"10.30476/IJMS.2023.96413.2795","DOIUrl":"10.30476/IJMS.2023.96413.2795","url":null,"abstract":"<p><strong>Background: </strong>Stem cell-derived secretome (SE) released into the extracellular space contributes to tissue repair. The present study aimed to investigate the impact of isolated secretome (SE) from adipose-derived mesenchymal stem cells (ASCs) on <i>Leishmania major</i> (<i>L. major</i>) lesions in BALB/c mice.</p><p><strong>Methods: </strong>This experimental study was conducted at Ahvaz University of Medical Sciences (Ahvaz, Iran) in 2021. Forty female BALB/c mice were infected with stationary phase promastigotes through intradermal injection in the bottom of their tail and randomly divided into four groups (n=10 per group). The mice were given SE (20 mg/mL), either alone or in combination with Glucantime (GC, 20 mg/mL/Kg), meglumine antimoniate (20 mg/mL/Kg) for the GC group, and phosphate-buffered saline (PBS) for the control group. After eight weeks, the lesion size, histopathology, the levels of Interleukin 10 (IL-10), and Interleukin 12 (IL-12) were assessed. For the comparison of values between groups, the parametric one-way ANOVA was used to assess statistical significance.</p><p><strong>Results: </strong>At the end of the experiment, the mice that received SE had smaller lesions (4.56±0.83 mm versus 3.62±0.59 mm, P=0.092), lower levels of IL-10 (66.5±9.7 pg/mL versus 285.4±25.2 pg/mL, P<0.001), and higher levels of IL-12 (152.2±14.2 pg/mL versus 24.2±4.4 pg/mL, P<0.001) than the control. Histopathology findings revealed that mice treated with SE had a lower parasite burden in lesions and spleen than the control group.</p><p><strong>Conclusion: </strong>The current study demonstrated that ADSC-derived SE could protect mice infected with <i>L. major</i> against leishmaniasis.</p>","PeriodicalId":14510,"journal":{"name":"Iranian Journal of Medical Sciences","volume":"49 2","pages":"121-129"},"PeriodicalIF":2.4,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10862109/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139735109","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Comparison of Telogen Effluvium Incidence in Hospitalized and Outpatient Settings after Recovery from COVID-19. COVID-19康复后住院患者和门诊患者毛发脱落症发病率的比较。
IF 2.4 Q2 MEDICINE, GENERAL & INTERNAL Pub Date : 2024-02-01 DOI: 10.30476/IJMS.2023.98516.3053
Ali Asilian, Fariba Iraji, Sayed Mohsen Hosseini, Parisa Mohammadian Dehkordi
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引用次数: 0
Correlation Between Intimate Partner Violence During Pregnancy and Parental Acceptance by Primiparous Mothers. 孕期亲密伴侣暴力与初产母亲对父母的接受度之间的相关性。
IF 2.4 Q2 MEDICINE, GENERAL & INTERNAL Pub Date : 2024-02-01 DOI: 10.30476/IJMS.2023.97325.2903
Masomah Jalili, Shahnaz Kohan, Mohammad Javad Tarrahi, Fatemeh Torabi

Background: Pregnancy and the transition to parenthood are periods in parents' lives that require tremendous adjustment. The physical and mental health of mothers during these periods is significantly associated with maternal acceptance. The present study aimed to evaluate the correlation between intimate partner violence (IPV) during pregnancy and parental acceptance by primiparous mothers in Isfahan, Iran.

Methods: A cross-sectional descriptive and correlational study was conducted from September 2021 to February 2022 in Isfahan, Iran. The target population was primiparous mothers in the postpartum period referred to nine different health centers across Isfahan. The participants (n=308) completed three questionnaires, namely demographic, Tabrizi intimate partner violence screening, and parental acceptance questionnaire. Data were analyzed using descriptive and inferential statistics with SPSS software (version 22.0). P<0.05 was considered statistically significant.

Results: The mean score of total IPV was 40.45±28.94. Domestic violence during pregnancy was reported by 59 (19.2%) mothers. The most common types were psychological violence (74.4%), followed by financial abuse (35.1%), sexual violence (17.2%), and physical violence (14.9%). The mean score of parental acceptance was 115.77±12.58. There was a significant inverse correlation between parental acceptance and IPV score (r=-0.15, P=0.005). The number of siblings and birth order had a significant inverse correlation with parental acceptance (r=-0.13, P=0.002; r=-0.13, P=0.002, respectively). Moreover, the age difference between the mothers and their next siblings had a significant direct correlation with parental acceptance (r=0.12, P=0.003).

Conclusion: Primiparous mothers subjected to IPV during pregnancy had lower parental acceptance after delivery.

背景:怀孕和为人父母是父母一生中需要进行巨大调整的时期。在这一时期,母亲的身心健康与母亲的接受程度有很大关系。本研究旨在评估伊朗伊斯法罕地区初产妇在怀孕期间遭受的亲密伴侣暴力(IPV)与父母接受度之间的相关性:方法:2021 年 9 月至 2022 年 2 月在伊朗伊斯法罕进行了一项横断面描述性和相关性研究。目标人群为伊斯法罕市 9 家不同医疗中心转诊的产后初产妇。参与者(308 人)填写了三份问卷,即人口统计学问卷、塔布里兹亲密伴侣暴力筛查问卷和父母接受度问卷。数据使用 SPSS 软件(22.0 版)进行描述性和推论性统计分析。结果IPV 总分的平均值为 40.45±28.94。有 59 名(19.2%)母亲报告在怀孕期间遭受家庭暴力。最常见的类型是心理暴力(74.4%),其次是经济虐待(35.1%)、性暴力(17.2%)和身体暴力(14.9%)。父母接受度的平均得分为 115.77±12.58。父母接受度与 IPV 分数之间存在明显的反相关关系(r=-0.15,P=0.005)。兄弟姐妹数量和出生顺序与父母接受度呈显著反相关(分别为 r=-0.13,P=0.002;r=-0.13,P=0.002)。此外,母亲与下一个兄弟姐妹的年龄差与父母的接受度有明显的直接相关性(r=0.12,P=0.003):结论:在孕期遭受过 IPV 的初产妇在产后对父母的接受度较低。
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引用次数: 0
Successful Sealing of Post-COVID-19 Bronchopleural Fistula with Computed Tomography Scan-Guided Percutaneous Cyanoacrylate Glue Injection: A Case Series. 计算机断层扫描引导下经皮氰基丙烯酸酯胶注射成功封堵 COVID-19 后支气管胸膜瘘:病例系列。
IF 2.4 Q2 MEDICINE, GENERAL & INTERNAL Pub Date : 2024-02-01 DOI: 10.30476/IJMS.2023.97068.2872
Alireza Rasekhi, Haleh Bozorgi, Seyed Masoom Masoompour, Parviz Mardani, Mohammad Reza Azimi Aval

Bronchopleural fistula (BPF), a sinus tract between the bronchial system and the pleural space, is associated with COVID-19 and can lead to pneumothorax, which increases the mortality rate. Due to the analytical status of COVID-19 patients, sealing the BPF necessitates the least minimal invasive treatment. Herein, we demonstrated a technique of sealing post-COVID-19 BPF with direct injection of cyanoacrylate glue under the guidance of a computed tomography scan. Following glue injection, the BPF was completely sealed in all four patients. In conclusion, in COVID-19 patients with small and distal BPF, percutaneous glue injection is recommended for BPF closure.

支气管胸膜瘘(BPF)是支气管系统和胸膜腔之间的窦道,与 COVID-19 相关,可导致气胸,从而增加死亡率。鉴于 COVID-19 患者的分析状况,封堵 BPF 需要最小的微创治疗。在此,我们展示了一种在计算机断层扫描引导下直接注射氰基丙烯酸酯胶水封堵 COVID-19 后 BPF 的技术。注射胶水后,所有四名患者的 BPF 都完全密封。总之,对于 COVID-19 BPF 较小且较远的患者,建议采用经皮注射胶水的方法进行 BPF 封闭。
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Iranian Journal of Medical Sciences
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