Pub Date : 2025-01-01DOI: 10.1016/j.jfo.2025.104419
{"title":"Remerciements aux rédacteurs adjoints et aux experts","authors":"","doi":"10.1016/j.jfo.2025.104419","DOIUrl":"10.1016/j.jfo.2025.104419","url":null,"abstract":"","PeriodicalId":14777,"journal":{"name":"Journal Francais D Ophtalmologie","volume":"48 1","pages":"Article 104419"},"PeriodicalIF":1.2,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143179003","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-01-01DOI: 10.1016/j.jfo.2024.104367
D.-M. Calinescu , A. El Maftouhi , C. Baudouin
La maculopathie médiane paracentrale aiguë est une lésion de la couche nucléaire interne et de la couche plexiforme externe de la macula associée aux maladies vasculaires locales ou systémiques pouvant induire une hypoxie rétinienne. Le mécanisme d’apparition peut être lié à l’augmentation de la pression intraoculaire qui crée les conditions d’une hypoperfusion au niveau de la vascularisation rétinienne. Nous présentons un cas qui montre une association possible entre la maculopathie médiane paracentrale aiguë et le glaucome avec un traumatisme par pression comme évènement déclencheur.
Paracentral acute middle maculopathy is a lesion of the inner nuclear layer and outer plexiform layer of the macula associated with local or systemic vascular diseases that can induce retinal hypoxia. The etiologic mechanism may be related to the increase in intraocular pressure which creates conditions of hypoperfusion in the retinal vasculature. We present a case that shows a possible association between paracentral acute middle maculopathy and glaucoma with the trauma of elevated intraocular pressure as a triggering event.
{"title":"Un cas de maculopathie médiane paracentrale aiguë post-traumatique associée au glaucome","authors":"D.-M. Calinescu , A. El Maftouhi , C. Baudouin","doi":"10.1016/j.jfo.2024.104367","DOIUrl":"10.1016/j.jfo.2024.104367","url":null,"abstract":"<div><div>La maculopathie médiane paracentrale aiguë est une lésion de la couche nucléaire interne et de la couche plexiforme externe de la macula associée aux maladies vasculaires locales ou systémiques pouvant induire une hypoxie rétinienne. Le mécanisme d’apparition peut être lié à l’augmentation de la pression intraoculaire qui crée les conditions d’une hypoperfusion au niveau de la vascularisation rétinienne. Nous présentons un cas qui montre une association possible entre la maculopathie médiane paracentrale aiguë et le glaucome avec un traumatisme par pression comme évènement déclencheur.</div></div><div><div>Paracentral acute middle maculopathy is a lesion of the inner nuclear layer and outer plexiform layer of the macula associated with local or systemic vascular diseases that can induce retinal hypoxia. The etiologic mechanism may be related to the increase in intraocular pressure which creates conditions of hypoperfusion in the retinal vasculature. We present a case that shows a possible association between paracentral acute middle maculopathy and glaucoma with the trauma of elevated intraocular pressure as a triggering event.</div></div>","PeriodicalId":14777,"journal":{"name":"Journal Francais D Ophtalmologie","volume":"48 1","pages":"Article 104367"},"PeriodicalIF":1.2,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142807315","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-12-26DOI: 10.1016/j.jfo.2024.104402
R Saidane, I Fendouli, L El Matri, F Mghaieth, Y Falfoul, R Limaiem, K El Matri
{"title":"Multimodal imaging of bilateral giant macular holes and anterior lenticonus revealing Alport syndrome.","authors":"R Saidane, I Fendouli, L El Matri, F Mghaieth, Y Falfoul, R Limaiem, K El Matri","doi":"10.1016/j.jfo.2024.104402","DOIUrl":"https://doi.org/10.1016/j.jfo.2024.104402","url":null,"abstract":"","PeriodicalId":14777,"journal":{"name":"Journal Francais D Ophtalmologie","volume":" ","pages":"104402"},"PeriodicalIF":1.2,"publicationDate":"2024-12-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142894419","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-12-21DOI: 10.1016/j.jfo.2024.104394
C R Lacher, N R Patel, M H Dastjerdi
{"title":"Sclerokeratouveitis presumed to be associated with durvalumab treatment.","authors":"C R Lacher, N R Patel, M H Dastjerdi","doi":"10.1016/j.jfo.2024.104394","DOIUrl":"https://doi.org/10.1016/j.jfo.2024.104394","url":null,"abstract":"","PeriodicalId":14777,"journal":{"name":"Journal Francais D Ophtalmologie","volume":" ","pages":"104394"},"PeriodicalIF":1.2,"publicationDate":"2024-12-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142877358","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-12-20DOI: 10.1016/j.jfo.2024.104391
D. Mikhail , A. Mihalache , R.S. Huang , T. Khairy , M.M. Popovic , D. Milad , R. Shor , A. Pereira , J. Kwok , P. Yan , D.T. Wong , P.J. Kertes , R. Duval , R.H. Muni
<div><h3>Purpose</h3><div>Prior literature has suggested a reduced performance of large language models (LLMs) in non-English analyses, including Arabic and French. However, there are no current studies testing the multimodal performance of ChatGPT in French ophthalmology cases, and comparing this to the results observed in the English literature. We compared the performance of ChatGPT-4 in French and English on open-ended prompts using multimodal input data from retinal cases.</div></div><div><h3>Methods</h3><div>GPT-4 was prompted in English and French using a public dataset containing 67 retinal cases from the ophthalmology education website OCTCases.com. The clinical case and accompanying ophthalmic images comprised the prompt, along with the open-ended question: “What is the most likely diagnosis?” Systematic prompting was used to identify and compare relevant factor(s) contributing to correct and incorrect responses. Diagnostic accuracy was the primary outcome, defined as the proportion of correctly diagnosed cases in French and English. Diagnoses were compared with the answer key on OCTCases to confirm correct or incorrect responses. Clinically relevant factors reported by the LLM as contributory to its decision-making were secondary endpoints.</div></div><div><h3>Results</h3><div>The diagnostic accuracies of GPT-4 in English and French were 35.8% and 28.4%, respectively (χ<sup>2</sup>, <em>P</em> <!-->=<!--> <!-->0.36). Imaging findings were reported as most influential for correct diagnosis in English (37.5%) and French (42.1%) (<em>P</em> <!-->=<!--> <!-->0.76). In incorrectly diagnosed cases, imaging findings were primarily implicated in English (35.6%) and French (33.3%) (<em>P</em> <!-->=<!--> <!-->0.81). In incorrectly diagnosed cases, the differential diagnosis list contained the correct diagnosis in 39.5% of English cases and 41.7% of French cases (<em>P</em> <!-->=<!--> <!-->0.83).</div></div><div><h3>Conclusion</h3><div>Our results suggest that GPT-4 performed similarly in English and French on all quantitative performance metrics measured. Ophthalmic images were identified in both languages as critical for correct diagnosis. Future research should assess LLM comprehension through the clarity, grammatical, cultural, and idiomatic accuracy of its responses.</div></div><div><h3>Objectif</h3><div>Comparer la performance de GPT-4 en français et en anglais sur des cas multimodaux en rétine.</div></div><div><h3>Méthode</h3><div>GPT-4 a été posée des questions en français et en anglais à l’aide d’un ensemble de données publiques contenant 67 cas rétiniens provenant du site web OCTCases.com. Les cas cliniques et les images ophtalmiques qui l’accompagnent constituaient les entrées, ainsi que la question ouverte : « Quel est le diagnostic le plus probable ? » Des demandes précises nous ont permis d’identifier et de comparer les facteurs pertinents contribuant aux réponses correctes et incorrectes. La performance au diagnostic était le rés
{"title":"Performance of ChatGPT in French language analysis of multimodal retinal cases","authors":"D. Mikhail , A. Mihalache , R.S. Huang , T. Khairy , M.M. Popovic , D. Milad , R. Shor , A. Pereira , J. Kwok , P. Yan , D.T. Wong , P.J. Kertes , R. Duval , R.H. Muni","doi":"10.1016/j.jfo.2024.104391","DOIUrl":"10.1016/j.jfo.2024.104391","url":null,"abstract":"<div><h3>Purpose</h3><div>Prior literature has suggested a reduced performance of large language models (LLMs) in non-English analyses, including Arabic and French. However, there are no current studies testing the multimodal performance of ChatGPT in French ophthalmology cases, and comparing this to the results observed in the English literature. We compared the performance of ChatGPT-4 in French and English on open-ended prompts using multimodal input data from retinal cases.</div></div><div><h3>Methods</h3><div>GPT-4 was prompted in English and French using a public dataset containing 67 retinal cases from the ophthalmology education website OCTCases.com. The clinical case and accompanying ophthalmic images comprised the prompt, along with the open-ended question: “What is the most likely diagnosis?” Systematic prompting was used to identify and compare relevant factor(s) contributing to correct and incorrect responses. Diagnostic accuracy was the primary outcome, defined as the proportion of correctly diagnosed cases in French and English. Diagnoses were compared with the answer key on OCTCases to confirm correct or incorrect responses. Clinically relevant factors reported by the LLM as contributory to its decision-making were secondary endpoints.</div></div><div><h3>Results</h3><div>The diagnostic accuracies of GPT-4 in English and French were 35.8% and 28.4%, respectively (χ<sup>2</sup>, <em>P</em> <!-->=<!--> <!-->0.36). Imaging findings were reported as most influential for correct diagnosis in English (37.5%) and French (42.1%) (<em>P</em> <!-->=<!--> <!-->0.76). In incorrectly diagnosed cases, imaging findings were primarily implicated in English (35.6%) and French (33.3%) (<em>P</em> <!-->=<!--> <!-->0.81). In incorrectly diagnosed cases, the differential diagnosis list contained the correct diagnosis in 39.5% of English cases and 41.7% of French cases (<em>P</em> <!-->=<!--> <!-->0.83).</div></div><div><h3>Conclusion</h3><div>Our results suggest that GPT-4 performed similarly in English and French on all quantitative performance metrics measured. Ophthalmic images were identified in both languages as critical for correct diagnosis. Future research should assess LLM comprehension through the clarity, grammatical, cultural, and idiomatic accuracy of its responses.</div></div><div><h3>Objectif</h3><div>Comparer la performance de GPT-4 en français et en anglais sur des cas multimodaux en rétine.</div></div><div><h3>Méthode</h3><div>GPT-4 a été posée des questions en français et en anglais à l’aide d’un ensemble de données publiques contenant 67 cas rétiniens provenant du site web OCTCases.com. Les cas cliniques et les images ophtalmiques qui l’accompagnent constituaient les entrées, ainsi que la question ouverte : « Quel est le diagnostic le plus probable ? » Des demandes précises nous ont permis d’identifier et de comparer les facteurs pertinents contribuant aux réponses correctes et incorrectes. La performance au diagnostic était le rés","PeriodicalId":14777,"journal":{"name":"Journal Francais D Ophtalmologie","volume":"48 3","pages":"Article 104391"},"PeriodicalIF":1.2,"publicationDate":"2024-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142872135","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-12-20DOI: 10.1016/j.jfo.2024.104400
S. Guven, B. Ayyildiz
<div><h3>Purpose</h3><div>To evaluate the compatibility and readability of ChatGPT-4 in providing responses to common inquiries about strabismus and amblyopia.</div></div><div><h3>Materials and methods</h3><div>A series of commonly asked questions were compiled, covering topics such as the definition, prevalence, diagnostic approaches, surgical and non-surgical treatment alternatives, postoperative guidelines, surgery-related risks, and visual prognosis associated with strabismus and amblyopia. Each question was asked three times on the online ChatGPT-4 platform both in English and French, with data collection conducted on February 18, 2024. The responses generated by ChatGPT-4 were evaluated by two independent pediatric ophthalmologists, who classified them as “acceptable,” “unacceptable,” or “incomplete.” Additionally, an online readability assessment tool called “readable” was utilized for readability analysis.</div></div><div><h3>Results</h3><div>The majority of responses, totaling 97% of the questions regarding strabismus and amblyopia, consistently met the criteria for acceptability. Only 3% of responses were classified as incomplete, with no instances of unacceptable responses observed. The average Flesch-Kincaid Grade Level and Flesch Reading Ease Score were calculated as 14.53<!--> <!-->±<!--> <!-->1.8 and 23.63<!--> <!-->±<!--> <!-->8.2, respectively. Furthermore, the means for all readability indices, including the Coleman-Liau index, the Gunning Fog index, and the SMOG index, were found to be 15.75<!--> <!-->±<!--> <!-->1.4, 16.96<!--> <!-->±<!--> <!-->2.4, and 16.05<!--> <!-->±<!--> <!-->1.6, respectively.</div></div><div><h3>Conclusions</h3><div>ChatGPT-4 consistently produced acceptable responses to the majority of the questions asked (97%). Nevertheless, the readability of these responses proved challenging for the average layperson, requiring a college-level education for comprehension. Further improvements, particularly in terms of readability, are necessary to enhance the advisory capacity of this AI software in providing eye and health-related guidance for patients, physicians, and the general public.</div></div><div><h3>Objectif</h3><div>Évaluer la compatibilité et la lisibilité de ChatGPT-4 pour fournir des réponses aux demandes sur le strabisme et l’amblyopie.</div></div><div><h3>Matériels et méthodes</h3><div>Une série de questions fréquemment posées ont été compilées, couvrant des sujets tels que la définition, la prévalence, les approches diagnostiques, les alternatives de traitement chirurgical et non chirurgical, les directives postopératoires, les risques liés à la chirurgie et le pronostic visuel associés au strabisme et à l’amblyopie. Chaque question a été posée trois fois sur la plateforme en ligne ChatGPT-4 en anglais et en français, avec une collecte de données effectuée le 18 février 2024. Les réponses générées par ChatGPT-4 ont été évaluées par deux ophtalmologistes pédiatriques indépendants, qui les ont classé
{"title":"Acceptability and readability of ChatGPT-4 based responses for frequently asked questions about strabismus and amblyopia","authors":"S. Guven, B. Ayyildiz","doi":"10.1016/j.jfo.2024.104400","DOIUrl":"10.1016/j.jfo.2024.104400","url":null,"abstract":"<div><h3>Purpose</h3><div>To evaluate the compatibility and readability of ChatGPT-4 in providing responses to common inquiries about strabismus and amblyopia.</div></div><div><h3>Materials and methods</h3><div>A series of commonly asked questions were compiled, covering topics such as the definition, prevalence, diagnostic approaches, surgical and non-surgical treatment alternatives, postoperative guidelines, surgery-related risks, and visual prognosis associated with strabismus and amblyopia. Each question was asked three times on the online ChatGPT-4 platform both in English and French, with data collection conducted on February 18, 2024. The responses generated by ChatGPT-4 were evaluated by two independent pediatric ophthalmologists, who classified them as “acceptable,” “unacceptable,” or “incomplete.” Additionally, an online readability assessment tool called “readable” was utilized for readability analysis.</div></div><div><h3>Results</h3><div>The majority of responses, totaling 97% of the questions regarding strabismus and amblyopia, consistently met the criteria for acceptability. Only 3% of responses were classified as incomplete, with no instances of unacceptable responses observed. The average Flesch-Kincaid Grade Level and Flesch Reading Ease Score were calculated as 14.53<!--> <!-->±<!--> <!-->1.8 and 23.63<!--> <!-->±<!--> <!-->8.2, respectively. Furthermore, the means for all readability indices, including the Coleman-Liau index, the Gunning Fog index, and the SMOG index, were found to be 15.75<!--> <!-->±<!--> <!-->1.4, 16.96<!--> <!-->±<!--> <!-->2.4, and 16.05<!--> <!-->±<!--> <!-->1.6, respectively.</div></div><div><h3>Conclusions</h3><div>ChatGPT-4 consistently produced acceptable responses to the majority of the questions asked (97%). Nevertheless, the readability of these responses proved challenging for the average layperson, requiring a college-level education for comprehension. Further improvements, particularly in terms of readability, are necessary to enhance the advisory capacity of this AI software in providing eye and health-related guidance for patients, physicians, and the general public.</div></div><div><h3>Objectif</h3><div>Évaluer la compatibilité et la lisibilité de ChatGPT-4 pour fournir des réponses aux demandes sur le strabisme et l’amblyopie.</div></div><div><h3>Matériels et méthodes</h3><div>Une série de questions fréquemment posées ont été compilées, couvrant des sujets tels que la définition, la prévalence, les approches diagnostiques, les alternatives de traitement chirurgical et non chirurgical, les directives postopératoires, les risques liés à la chirurgie et le pronostic visuel associés au strabisme et à l’amblyopie. Chaque question a été posée trois fois sur la plateforme en ligne ChatGPT-4 en anglais et en français, avec une collecte de données effectuée le 18 février 2024. Les réponses générées par ChatGPT-4 ont été évaluées par deux ophtalmologistes pédiatriques indépendants, qui les ont classé","PeriodicalId":14777,"journal":{"name":"Journal Francais D Ophtalmologie","volume":"48 3","pages":"Article 104400"},"PeriodicalIF":1.2,"publicationDate":"2024-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142872131","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
<div><h3>Purpose</h3><div>To correlate fluorescein dye disappearance test (FDDT) grades and endoscopic dye transit times (EDTT) in patients with patent osteotomies after nasolacrimal duct obstruction surgery (NLDO).</div></div><div><h3>Design</h3><div>Cross-sectional study.</div></div><div><h3>Methods</h3><div>All adult patients with patent osteotomies post-external dacryocystorhinostomy (Ex-DCR) or post-endoscopic dacryocystorhinostomy (EDCR) for NLDO were included in this cross-sectional investigation. Patients with dry eye and endoscopically unidentified osteotomy sites were excluded from the study. The FDDT grade, EDTT and lacrimal symptom questionnaire (Lac-Q) scores were documented for all patients.</div></div><div><h3>Results</h3><div>This study included 39 patients. Nineteen had undergone EDCR, twenty Ex-DCR. The FDDT grade and EDTT were positively correlated (r<!--> <!-->=<!--> <!-->0.32, <em>P</em> <!-->=<!--> <!-->0.045). The mean Lac-Q score was not correlated with FDDT grade (r<!--> <!-->=<!--> <!-->−0.01, <em>P</em> <!-->=<!--> <!-->0.951) or EDTT (r<!--> <!-->=<!--> <!-->0.07, <em>P</em> <!-->=<!--> <!-->0.669). There were no significant differences in the FDDT grade, EDTT, Lac-Q score or ostial characteristics between Ex-DCR and EDCR.</div></div><div><h3>Conclusion</h3><div>FDDT grading correlates with EDTT, suggesting that these tests may be used interchangeably based on the clinician's ease of access and instrumentation. There was no correlation between the symptoms of lacrimal outflow obstruction with objective evidence of drainage.</div></div><div><h3>Objectif</h3><div>Corréler le grade du test de disparition du colorant à la fluorescéine (FDDT) et le temps de transit endoscopique du colorant (EDTT) chez les patients présentant des ostéotomies perméables après une chirurgie d’obstruction du canal lacrymo-nasal (NLDO).</div></div><div><h3>Conception</h3><div>Étude transversale.</div></div><div><h3>Méthodes</h3><div>Tous les patients adultes présentant des ostéotomies perméables après une dacryocystorhinostomie externe (Ex-DCR) ou une dacryocystorhinostomie post-endoscopique (EDCR) pour NLDO ont été inclus dans cette enquête transversale. Les patients souffrant de sécheresse oculaire et de sites d’ostéotomie non identifiés par endoscopie ont été exclus de l’étude. Le grade FDDT, l’EDTT et le score du questionnaire sur les symptômes lacrymaux (Lac-Q) ont été documentés pour tous les patients.</div></div><div><h3>Résultats</h3><div>Cette étude a inclus 39 patients. Dix-neuf avaient EDCR, vingt Ex-DCR. Le grade FDDT et EDTT étaient positivement corrélés (r<!--> <!-->=<!--> <!-->0,32, <em>p</em> <!-->=<!--> <!-->0,045). Le score Lac-Q moyen n’était pas corrélé au grade FDDT (r<!--> <!-->=<!--> <!-->−0,01, <em>p</em> <!-->=<!--> <!-->0,951) ou EDTT (r<!--> <!-->=<!--> <!-->0,07, <em>p</em> <!-->=<!--> <!-->0,669). Il n’y avait pas de différences significatives dans le grade FDDT, l’EDTT, le score Lac-Q et les caractéristiques ostiale
{"title":"Correlation of the fluorescein dye disappearance test and endoscopic dye transit time in patients after surgery for nasolacrimal duct obstruction","authors":"E.L.M. Tai , T.P. Amirul-Hasbi , A.H. Zamli , K.A. Rajet , Y.C. Kueh","doi":"10.1016/j.jfo.2024.104388","DOIUrl":"10.1016/j.jfo.2024.104388","url":null,"abstract":"<div><h3>Purpose</h3><div>To correlate fluorescein dye disappearance test (FDDT) grades and endoscopic dye transit times (EDTT) in patients with patent osteotomies after nasolacrimal duct obstruction surgery (NLDO).</div></div><div><h3>Design</h3><div>Cross-sectional study.</div></div><div><h3>Methods</h3><div>All adult patients with patent osteotomies post-external dacryocystorhinostomy (Ex-DCR) or post-endoscopic dacryocystorhinostomy (EDCR) for NLDO were included in this cross-sectional investigation. Patients with dry eye and endoscopically unidentified osteotomy sites were excluded from the study. The FDDT grade, EDTT and lacrimal symptom questionnaire (Lac-Q) scores were documented for all patients.</div></div><div><h3>Results</h3><div>This study included 39 patients. Nineteen had undergone EDCR, twenty Ex-DCR. The FDDT grade and EDTT were positively correlated (r<!--> <!-->=<!--> <!-->0.32, <em>P</em> <!-->=<!--> <!-->0.045). The mean Lac-Q score was not correlated with FDDT grade (r<!--> <!-->=<!--> <!-->−0.01, <em>P</em> <!-->=<!--> <!-->0.951) or EDTT (r<!--> <!-->=<!--> <!-->0.07, <em>P</em> <!-->=<!--> <!-->0.669). There were no significant differences in the FDDT grade, EDTT, Lac-Q score or ostial characteristics between Ex-DCR and EDCR.</div></div><div><h3>Conclusion</h3><div>FDDT grading correlates with EDTT, suggesting that these tests may be used interchangeably based on the clinician's ease of access and instrumentation. There was no correlation between the symptoms of lacrimal outflow obstruction with objective evidence of drainage.</div></div><div><h3>Objectif</h3><div>Corréler le grade du test de disparition du colorant à la fluorescéine (FDDT) et le temps de transit endoscopique du colorant (EDTT) chez les patients présentant des ostéotomies perméables après une chirurgie d’obstruction du canal lacrymo-nasal (NLDO).</div></div><div><h3>Conception</h3><div>Étude transversale.</div></div><div><h3>Méthodes</h3><div>Tous les patients adultes présentant des ostéotomies perméables après une dacryocystorhinostomie externe (Ex-DCR) ou une dacryocystorhinostomie post-endoscopique (EDCR) pour NLDO ont été inclus dans cette enquête transversale. Les patients souffrant de sécheresse oculaire et de sites d’ostéotomie non identifiés par endoscopie ont été exclus de l’étude. Le grade FDDT, l’EDTT et le score du questionnaire sur les symptômes lacrymaux (Lac-Q) ont été documentés pour tous les patients.</div></div><div><h3>Résultats</h3><div>Cette étude a inclus 39 patients. Dix-neuf avaient EDCR, vingt Ex-DCR. Le grade FDDT et EDTT étaient positivement corrélés (r<!--> <!-->=<!--> <!-->0,32, <em>p</em> <!-->=<!--> <!-->0,045). Le score Lac-Q moyen n’était pas corrélé au grade FDDT (r<!--> <!-->=<!--> <!-->−0,01, <em>p</em> <!-->=<!--> <!-->0,951) ou EDTT (r<!--> <!-->=<!--> <!-->0,07, <em>p</em> <!-->=<!--> <!-->0,669). Il n’y avait pas de différences significatives dans le grade FDDT, l’EDTT, le score Lac-Q et les caractéristiques ostiale","PeriodicalId":14777,"journal":{"name":"Journal Francais D Ophtalmologie","volume":"48 3","pages":"Article 104388"},"PeriodicalIF":1.2,"publicationDate":"2024-12-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142872133","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-12-19DOI: 10.1016/j.jfo.2024.104393
Z. Yozgat , B.S. Durmus Ece , M.U. Isik , S. Ilguy , M.C. Sabaner
<div><h3>Purpose</h3><div>To evaluate the natural history of dry age-related macular degeneration (AMD) through advanced retinal pigment epithelium (RPE) analysis and sub-RPE illumination (SRI) data and to elucidate their correlation with disease progression.</div></div><div><h3>Methods</h3><div>A total of 82 patients with dry AMD were included in this longitudinal study. Spectral-domain optical coherence tomography (SD-OCT) was utilized to evaluate central macular thickness (CMT), central retinal thickness (CRT), foveal outer nuclear layer (ONL) thickness, and ellipsoid zone (EZ) integrity. Advanced retinal pigment epithelium (RPE) analysis software was used to obtain area and volume data at 3<!--> <!-->mm and 5<!--> <!-->mm circles, as well as sub-RPE illumination (SRI) assessments within 5<!--> <!-->mm circles.</div></div><div><h3>Results</h3><div>After exclusions, the final cohort consisted of 54 eyes of 54 patients (29 female), with a mean age of 74.72<!--> <!-->±<!--> <!-->8.38<!--> <!-->years and a mean follow-up period of 13.92<!--> <!-->±<!--> <!-->1.7<!--> <!-->months. Both area (mm<sup>2</sup>) and volume (mm<sup>3</sup>) within the 3<!--> <!-->mm and 5<!--> <!-->mm circles were significantly increased at the final visit (all <em>P</em> <!--><<!--> <!-->0.001). From the SRI data, the area within the 5<!--> <!-->mm circle (mm<sup>2</sup>) was also identified as significantly higher at the final visit (<em>P</em> <!--><<!--> <!-->0.001). CMT, CRT, and ONL thickness decreased significantly by the final visit (<em>P</em> <!-->=<!--> <!-->0.014, <em>P</em> <!--><<!--> <!-->0.001, and <em>P</em> <!--><<!--> <!-->0.001, respectively). Baseline and final LogMAR visual acuity values showed a significant inverse correlation with the distance of SRI from the fovea (<em>P</em> <!-->=<!--> <!-->0.03, r<!--> <!-->=<!--> <!-->–0.347 and <em>P</em> <!-->=<!--> <!-->0.04, r<!--> <!-->=<!--> <!-->–0.382, respectively). Baseline SRI values were higher in patients with EZ disruption at onset [0.8 (0.1–1.19) vs. 0.0 (0–0.1), <em>P</em> <!-->=<!--> <!-->0.002]. Furthermore, patients with initial EZ disruption had significantly higher final SRI values than those without [1.1 (0.3–2.1) vs. 0.1 (0.1–0.2), <em>P</em> <!-->=<!--> <!-->0.038]. A significant positive correlation was found between the initial SRI area and final LogMAR visual acuity (<em>P</em> <!--><<!--> <!-->0.001, r<!--> <!-->=<!--> <!-->0.645).</div></div><div><h3>Conclusion</h3><div>Initial SRI area may predict the risk of vision loss over a 12-month follow-up period and could serve as a prognostic marker for progression of dry AMD.</div></div><div><h3>Objectif</h3><div>Évaluer l’histoire naturelle de la sèche via une analyse de l’épithélium pigmentaire rétinien (EPR) et des données d’éclairage sous-EPR (SRI) pour leur lien avec la progression de la maladie.</div></div><div><h3>Méthodes</h3><div>Cette étude longitudinale a inclus 82 patients atteints de DMLA sèche. L'évaluation
{"title":"Could “Sub-RPE illumination” be a prognostic marker? A prospective dry AMD study","authors":"Z. Yozgat , B.S. Durmus Ece , M.U. Isik , S. Ilguy , M.C. Sabaner","doi":"10.1016/j.jfo.2024.104393","DOIUrl":"10.1016/j.jfo.2024.104393","url":null,"abstract":"<div><h3>Purpose</h3><div>To evaluate the natural history of dry age-related macular degeneration (AMD) through advanced retinal pigment epithelium (RPE) analysis and sub-RPE illumination (SRI) data and to elucidate their correlation with disease progression.</div></div><div><h3>Methods</h3><div>A total of 82 patients with dry AMD were included in this longitudinal study. Spectral-domain optical coherence tomography (SD-OCT) was utilized to evaluate central macular thickness (CMT), central retinal thickness (CRT), foveal outer nuclear layer (ONL) thickness, and ellipsoid zone (EZ) integrity. Advanced retinal pigment epithelium (RPE) analysis software was used to obtain area and volume data at 3<!--> <!-->mm and 5<!--> <!-->mm circles, as well as sub-RPE illumination (SRI) assessments within 5<!--> <!-->mm circles.</div></div><div><h3>Results</h3><div>After exclusions, the final cohort consisted of 54 eyes of 54 patients (29 female), with a mean age of 74.72<!--> <!-->±<!--> <!-->8.38<!--> <!-->years and a mean follow-up period of 13.92<!--> <!-->±<!--> <!-->1.7<!--> <!-->months. Both area (mm<sup>2</sup>) and volume (mm<sup>3</sup>) within the 3<!--> <!-->mm and 5<!--> <!-->mm circles were significantly increased at the final visit (all <em>P</em> <!--><<!--> <!-->0.001). From the SRI data, the area within the 5<!--> <!-->mm circle (mm<sup>2</sup>) was also identified as significantly higher at the final visit (<em>P</em> <!--><<!--> <!-->0.001). CMT, CRT, and ONL thickness decreased significantly by the final visit (<em>P</em> <!-->=<!--> <!-->0.014, <em>P</em> <!--><<!--> <!-->0.001, and <em>P</em> <!--><<!--> <!-->0.001, respectively). Baseline and final LogMAR visual acuity values showed a significant inverse correlation with the distance of SRI from the fovea (<em>P</em> <!-->=<!--> <!-->0.03, r<!--> <!-->=<!--> <!-->–0.347 and <em>P</em> <!-->=<!--> <!-->0.04, r<!--> <!-->=<!--> <!-->–0.382, respectively). Baseline SRI values were higher in patients with EZ disruption at onset [0.8 (0.1–1.19) vs. 0.0 (0–0.1), <em>P</em> <!-->=<!--> <!-->0.002]. Furthermore, patients with initial EZ disruption had significantly higher final SRI values than those without [1.1 (0.3–2.1) vs. 0.1 (0.1–0.2), <em>P</em> <!-->=<!--> <!-->0.038]. A significant positive correlation was found between the initial SRI area and final LogMAR visual acuity (<em>P</em> <!--><<!--> <!-->0.001, r<!--> <!-->=<!--> <!-->0.645).</div></div><div><h3>Conclusion</h3><div>Initial SRI area may predict the risk of vision loss over a 12-month follow-up period and could serve as a prognostic marker for progression of dry AMD.</div></div><div><h3>Objectif</h3><div>Évaluer l’histoire naturelle de la sèche via une analyse de l’épithélium pigmentaire rétinien (EPR) et des données d’éclairage sous-EPR (SRI) pour leur lien avec la progression de la maladie.</div></div><div><h3>Méthodes</h3><div>Cette étude longitudinale a inclus 82 patients atteints de DMLA sèche. L'évaluation ","PeriodicalId":14777,"journal":{"name":"Journal Francais D Ophtalmologie","volume":"48 3","pages":"Article 104393"},"PeriodicalIF":1.2,"publicationDate":"2024-12-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142872134","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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