Journal of Advanced Pharmaceutical Technology & Research最新文献

The current study aimed at evaluation of the awareness of undergraduate dental students regarding the use of digital imaging that are used for orthodontic diagnosis and treatment. An online survey using google forms was conducted among the undergraduate dental students as a part of this study setting. The sample size of participants was 109. The survey was composed of a set of 14 questions including demographics. Ethical clearance was obtained from the Institutionalized ethical committee. SPSS software was used for data analysis and descriptive statistics. Among the entire population, 46.2% participants said that they would be using digital dental imaging during their practices and in their career and the remaining 53.8% participants said that they would not be using digital imaging due to various reasons. This study found out that undergraduate dental students have an average level of awareness regarding the use of digital dental imaging that are used for orthodontic diagnosis and treatment.

In countries with a high amount of geriatric patients, it is mandatory for a dental clinician to have working knowledge on complete denture (CD) procedures. The aim of this study was to troubleshoot the errors in denture fabrication by assessing the difficulties in clinical procedures. A questionnaire was distributed among dental undergraduates across the country in the present study. A total of 26 questions were included in the study. An online sharing medium was used for distribution and a total of 140 responses were received. SPSS for windows, version 20 was used for data tabulation. Descriptive statistics and Chi-square test were done. The results of this study revealed that jaw relation was the most difficult procedure followed by border molding. Multiple problems arise from the practitioner's end due to the lack of knowledge. One of the causes for these problems could be inability to learn the principles and procedures during the undergraduate program. This must be addressed at the base level so that better care can be given to patients.

The antibacterial, antiviral, and anticancer properties of ivermectin make it a wonder drug with a wide range of possible applications. It works against a variety of microorganisms, including viruses. Ivermectin has a wide range of antiviral effects, according to in vivo research in animal models. Because ivermectin is involved in a range of biological processes, it could be a promising therapeutic candidate for viruses such as COVID-19 and other positive-sense single-stranded RNA viruses. The study aims to analyze the awareness about the current status of usage of ivermectin in management of COVID among students studying in a private dental college. A study based on questionnaire was organized among students studying in a private dental college in Tamil Nadu. The subjects were asked a series of structural questions based on the usage of ivermectin in management of COVID. The questionnaire was prepared with 10 questions. 150 individuals completed the questionnaire; all of their answers were tallied in excel and imported into SPSS. For statistical analysis, the Chi-square test was performed. Excel was used to tabulate and enter the data, and the SPSS package software was used to analyze it. The study's threshold for statistical significance was set at P < 0.05. From this study, we found that the students had limited knowledge about the usage of ivermectin for management of COVID. More studies should be conducted to widen the knowledge among the students about the current affairs of the world.

Dental treatment under GA is a compelling method for giving therapeutically important consideration to those youngsters who might be intellectually juvenile, exceptionally restless, medicinally split the difference, or unfit to get treatment in a customary office setting. While the traditional work on concerning corticosteroids is likely innocuous and perhaps gainful with lower prophylactic dosages and the nature of oral admission was additionally unaffected. The study aimed to investigate commonly prescribed corticosteroids in children undergoing full-mouth dental management under general anesthesia. A single-centered retrospective study among pediatric patients treated under general anesthesia of the age group of 0-13 years. The sample size is 124. Data were collected and tabulated. Data were statistically analyzed using the SPSS software version 23. Chi-square test and Pearson correlation were done using the software and P < 0.05 was considered statistically significant. The results show that 79.67% commonly prescribed dexamethasone, whereas 20.33% use hydrocortisone, providing the age groups between 0 and 3 has higher prescribing of corticosteroids. From this study, it is concluded that since the P value was more than 0.05, there is no significant statistical difference that has been analyzed. Dexamethasone is the commonly prescribed corticosteroid in children undergoing full-mouth rehabilitation under GA, followed by hydrocortisone.

The aim of the present study was to assess the prevalence of usage of various removable appliances among undergraduate dental students in private dental colleges. Ethical approval for the study was obtained from the Institutional Review Board of Saveetha Institute of Medical and Technical Sciences, Chennai, India. A dental record of patients was investigated. Data evaluation was completed and entered into Microsoft Excel. Gender distribution among the cohorts was assessed. The most commonly used appliance is Hawley's appliance (61), followed by Essix retainer (25), Begg's wrap-around retainer (23), Hawley's appliance with tongue crib (16), cantilever spring (7), splint (7), and T spring (1), respectively. The majority of the females (36) took Hawley's appliance. The difference was not statistically significant between both the arches and between the male and female population. Hawley's appliance is the most commonly used removable appliance among dental graduates.

The aim of this study is to analyze and characterize the antimicrobial effect of cerium oxide nanoparticles (NP) synthesized using neem and ginger. Finely grounded neem and ginger powder were taken and mixed with distilled water. This mixture was then heated and filtered. Ammonium cerium nitrate dissolved in distilled water. Both the mixtures were mixed and stirred magnetically. A double-beam ultraviolet-visible spectrophotometer was used to monitor color changes. The extract was centrifuged at 8000 rpm for 15 min. The final pellet was powdered using a hot air oven at 70°C for 24 h. Visualization was done by transmission electron microscopy and spherical morphology was noted, with an average diameter of 5 nm, in aggregated form. The sample containing 100 mg of cerium oxide shows the most significant effect on the zone of inhibition of 11 mm of Staphylococcus aureus. The results obtained in the current study confirmed that CeO-NP possessed antioxidant and cytotoxic properties.

Kaempferia galanga rhizome (KGR) is a stemless, sweet-smelling, enduring, and rhizomatous monocotyledonous plant of the ginger family also called sand ginger or kencur. lt possesses many pharmacological effects and the goal of this study is to use several solvent solutions to determine the antioxidant and anti-diabetic potential of KGR. By observing KGR's alpha-glucosidase and alpha-amylase inhibitory activity, the in vitro diabetic activity was assessed. The in vitro cancer preventive action was evaluated by doing the 2,2-diphenyl-1-picrylhydrazyl test. The outcomes of the study showed increase in dose-dependent percentage of inhibition in α-amylase and α-glucosidase activity for both extract and standard ranging from 100 to 500 μg/ml. The current review proposes that the concentrate of KGR could be utilized for the treatment of diabetes mellitus as well with respect to dealing with the oxidative stress-related diseases.

This study aimed to synthesize selenium nanoparticles (SeNPs) using stevia plant leaves and to evaluate the antimicrobial effect of nano-sized particles of selenium. A new organic synthesis of nano-sized selenium particles was done in this study. In this study, stevia leaves for the synthesis of nano-sized particles along with sodium selenite were done. This mixture was mixed homogeneously using an orbital shaker overnight. The color change indicated the formation of SeNPs. The SeNPs were evaluated for their size and shape and their antimicrobial property was assessed. SeNPs showed excellent antimicrobial activity against Candida albicans at 100 μL concentration. At 25 μL and 50 μL, C. albicans showed intermediate susceptibility to SeNPs which also indicated a good antimicrobial potential. Following C. albicans, SeNPs showed good antimicrobial potential against Streptococcus mutans at all concentrations. SeNPs possessed good antimicrobial activity against most common oral pathogens.

Wound damage must be shielded from inflammatory responses caused by the external environment, while also receiving adequate moisture and promoting wound healing. Cinnamomum verum, Coleus aromaticus/amboinicus, and Mentha have proven effects on anti-inflammatory and antimicrobial effects as separate in various studies, but no studies have observed the synergistic effects of one herb on the other. The aim of the present study is to assess the anti-inflammatory and antimicrobial properties of karpooravalli, mint, and cinnamon formulation against wound pathogens for better healing of mouth ulcers through an in vitro study for further mouth paint preparation. Herbal extract is prepared using herbal plants karpooravalli, mint, and cinnamon. We studied the antimicrobial effects on Escherichia coli, Staphylococcus aureus, and Pseudomonas with ampicillin antibiotic disks as positive control and anti-inflammatory with control of diclofenac sodium. The antimicrobial activity of zone of inhibition increased with higher concentration of 100 μL against E. coli, S. aureus, and Pseudomonas at 20 mm, 18 mm, and 15 mm, respectively. The anti-inflammatory activity showed the highest percentage of inhibition using 50 μL with 91.5%; this reveals good anti-inflammatory activity by the synergistic action of the herbal formulation. The synergistic effect of the herbal formulation had a comparable anti-inflammatory activity as that of the standard. Hence, it can be employed in large-scale production and may be used for fabricating a natural product based on mouthwashes and mouth paints.

The present invention relates to dental compositions that include a phosphorescent material, more particularly, adding phosphorescent material to waxes that used in dentistry. The aim of the study is to develop a wax that has innate phosphorescent properties. Three groups of samples were taken in which the phosphorescent material was added. Three groups were later compared for their phosphorescent property in the material. All the samples in the initial molten state were poured into a mold made of silicone impression material and allowed to set. The material was placed in a dark room, and visual examination was done to compare the materials. From the samples obtained, paraffin wax showed more phosphorescent property than beeswax. The least phosphorescent property was seen in marginal wax. It can be concluded from this study that paraffin wax showed the most phosphorescent property.