Pub Date : 2024-02-27DOI: 10.9734/jamps/2024/v26i4679
B. Oyan, Sarah Abere, Ernest O Nwazor, Aisha O. Ajala, Florence K Briggs, Linda Iroegbu-Emeruem
Background: Elevated blood pressure (BP) is associated with increased cardiovascular disease mortality and all-cause mortality. Despite availability of medication for treatment of hypertension and prevention of complications, the goal of universal optimal BP control has remained elusive. This dual center study aims to assess the level of blood pressure control in hypertensive patients and its determinants. Methods: This was a descriptive cross-sectional study conducted in the Cardiology outpatient clinics of the Rivers State University Teaching Hospital and the University of Port Harcourt Teaching Hospital. A total of 426 previously diagnosed hypertensive subjects on follow up for at least 6 months were recruited via convenience sampling. Uncontrolled BP was defined as systolic BP of ≥140mmHg and/or diastolic BP of ≥90mmHg. Data was analysed using SPSS version 22. Bivariate logistic regression analysis was used to determine predictors of poor blood pressure control and p-values <0.05 were considered statistically significant. Results: The mean age of the respondents was 57.89±12.17years and 237(55.6%) were women. The mean systolic BP was 139.9±17.5mmHg, whereas the mean diastolic BP was 88.2±14.4mmHg. Controlled BP was recorded in 184(43.2%) persons, while 242(56.8%) had uncontrolled BP. Factors significantly associated with uncontrolled BP were household monthly income (p=0.024), Body Mass Index (p=0.002), poor adherence to medication (p=0.001) and physical inactivity (p=0.047). Conclusion: Uncontrolled BP was found in more than half of the patients on follow up in tertiary care. There is need to intensify health education and care of hypertensive patients as a strategy to enhance blood pressure control and mitigate cardiovascular complications.
{"title":"Blood Pressure Control and Its Determinants Among Outpatient Hypertensive Subjects in Port Harcourt: A Survey of Two Teaching Hospitals","authors":"B. Oyan, Sarah Abere, Ernest O Nwazor, Aisha O. Ajala, Florence K Briggs, Linda Iroegbu-Emeruem","doi":"10.9734/jamps/2024/v26i4679","DOIUrl":"https://doi.org/10.9734/jamps/2024/v26i4679","url":null,"abstract":"Background: Elevated blood pressure (BP) is associated with increased cardiovascular disease mortality and all-cause mortality. Despite availability of medication for treatment of hypertension and prevention of complications, the goal of universal optimal BP control has remained elusive. This dual center study aims to assess the level of blood pressure control in hypertensive patients and its determinants. \u0000Methods: This was a descriptive cross-sectional study conducted in the Cardiology outpatient clinics of the Rivers State University Teaching Hospital and the University of Port Harcourt Teaching Hospital. A total of 426 previously diagnosed hypertensive subjects on follow up for at least 6 months were recruited via convenience sampling. Uncontrolled BP was defined as systolic BP of ≥140mmHg and/or diastolic BP of ≥90mmHg. Data was analysed using SPSS version 22. Bivariate logistic regression analysis was used to determine predictors of poor blood pressure control and p-values <0.05 were considered statistically significant. \u0000Results: The mean age of the respondents was 57.89±12.17years and 237(55.6%) were women. The mean systolic BP was 139.9±17.5mmHg, whereas the mean diastolic BP was 88.2±14.4mmHg. Controlled BP was recorded in 184(43.2%) persons, while 242(56.8%) had uncontrolled BP. Factors significantly associated with uncontrolled BP were household monthly income (p=0.024), Body Mass Index (p=0.002), poor adherence to medication (p=0.001) and physical inactivity (p=0.047). \u0000Conclusion: Uncontrolled BP was found in more than half of the patients on follow up in tertiary care. There is need to intensify health education and care of hypertensive patients as a strategy to enhance blood pressure control and mitigate cardiovascular complications.","PeriodicalId":14903,"journal":{"name":"Journal of Advances in Medical and Pharmaceutical Sciences","volume":"63 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140426763","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-02-20DOI: 10.9734/jamps/2024/v26i4678
Koka Gogichashvili, Zviad Malazonia, Tornike Kldiashvili, Ciara Francesca Maxwell
This prospective study aimed to comprehensively investigate the impact of L-Lysine aescinat supplementation on the neurological outcomes of patients recovering from spinal fractures and traumatic spine injuries. A total of 32 patients were recruited and categorised into two groups: Group A (n=16), receiving L-Lysine aescinat supplementation, and Group B (N=16), serving as the control group without L-Lysine aescinat administration. The primary objective was to assess changes in the Karnofsky performance scale, a functional and well-being neurological assessment tool especially for those undergoing operations or with chronic illness, over a follow up period of one month in order to determine if L-Lysine aescinat had an immediate effect on recovery in the post-operative period. Urinary dysfunction was noted, alongside the location of the fracture, type of surgery and if there were any significant comorbidities.
{"title":"Evaluating the Therapeutic Efficacy of L-Lysine Aescinat Supplementation on Neurological Outcomes in Patients with Spinal Fractures and Traumatic Spine Injuries: A Prospective Cohort Study from Tbilisi, Georgia","authors":"Koka Gogichashvili, Zviad Malazonia, Tornike Kldiashvili, Ciara Francesca Maxwell","doi":"10.9734/jamps/2024/v26i4678","DOIUrl":"https://doi.org/10.9734/jamps/2024/v26i4678","url":null,"abstract":"This prospective study aimed to comprehensively investigate the impact of L-Lysine aescinat supplementation on the neurological outcomes of patients recovering from spinal fractures and traumatic spine injuries. A total of 32 patients were recruited and categorised into two groups: Group A (n=16), receiving L-Lysine aescinat supplementation, and Group B (N=16), serving as the control group without L-Lysine aescinat administration. The primary objective was to assess changes in the Karnofsky performance scale, a functional and well-being neurological assessment tool especially for those undergoing operations or with chronic illness, over a follow up period of one month in order to determine if L-Lysine aescinat had an immediate effect on recovery in the post-operative period. Urinary dysfunction was noted, alongside the location of the fracture, type of surgery and if there were any significant comorbidities.","PeriodicalId":14903,"journal":{"name":"Journal of Advances in Medical and Pharmaceutical Sciences","volume":"160 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140447509","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-02-19DOI: 10.9734/jamps/2024/v26i3676
George-Opuda, I. M, Etuk, E.J, Elechi-Amadi, K. N, Okolonkwo, B. N, Adegoke, O. A., Ohaka, T. P., Elekima, I.
Aim: To evaluate the effect of vitamin C supplementation on lipid profile parameters among oil and gas workers occupationally exposed to petroleum fumes through inhalation over a period of 12 months. Study Design: A total of 150 subjects between the age ranges of 18 to 45 years old were recruited for the study of which 50 subjects were exposed to petroleum fumes and were given vitamin C supplementation (group1), 50 were also exposed to petroleum without vitamin C (Group 2) and 50 subjects are non-oil and gas workers (control subjects). Methodology: The Group 1 subjects were orally administered vitamin C supplements of 100mg/day for 60 days before sample collection while Group 2 subjects exposed to petroleum fumes were not given vitamin C or took vitamin during the period of the study. The control subjects were non-oil and gas workers. At the end of the experiment (60 days), blood specimens were collected from group 1, group 2, and the control subjects. Lipid parameters such as cholesterol, triglycerides, high-density lipoprotein, low-density lipoprotein, and very low-density lipoprotein were analysed using enzymatic methods. Statistical analysis was done using GraphPad Prism and results were expressed as Mean±SD. Results: The results indicated significantly higher values in total cholesterol, triglyceride, low-density lipoprotein, and very low-density lipoprotein in the petroleum fumes exposed subjects compared to control subjects except for high-density lipoprotein which indicated significantly lower values. When those exposed were given vitamin C supplementation, there was a significant reduction in the lipid parameters except HDL-C which indicated a significantly higher value compared with those exposed without vitamin C supplementation administered orally at 100mg for 60 days at P=.05. Conclusion: The study has shown that occupational exposure to petroleum fumes is associated with dyslipidaemia. However, the use of 100mg of vitamin C daily for 60 days ameliorated the degree of dyslipidaemia associated with occupational exposure to petroleum fumes. Vitamin C could be considered as a preventive means to mitigate or ameliorate cardiovascular risks due to occupational exposure to petroleum fumes and products among workers.
目的：评估维生素 C 补充剂对通过吸入石油烟雾而职业暴露于石油和天然气的工人的血脂特征参数的影响，为期 12 个月。研究设计：共招募 150 名年龄介于 18 至 45 岁之间的受试者进行研究，其中 50 名受试者暴露于石油烟雾并补充维生素 C（第一组），50 名受试者同样暴露于石油烟雾但未补充维生素 C（第二组），50 名受试者为非石油和天然气工人（对照组）。研究方法： 第一组受试者在样本采集前口服维生素 C 补充剂 100 毫克/天，为期 60 天；第二组受试者暴露于石油烟雾中，在研究期间未服用维生素 C 或服用维生素。对照组受试者为非石油和天然气工人。实验结束时（60 天），从第 1 组、第 2 组和对照组受试者身上采集血液样本。 使用酶法分析胆固醇、甘油三酯、高密度脂蛋白、低密度脂蛋白和极低密度脂蛋白等血脂参数。使用 GraphPad Prism 进行统计分析，结果以均数±SD 表示。结果结果表明，与对照组相比，接触石油烟雾的受试者的总胆固醇、甘油三酯、低密度脂蛋白和极低密度脂蛋白的数值明显较高，但高密度脂蛋白的数值明显较低。与未口服维生素 C 补充剂（100 毫克，连续 60 天）的受试者相比，接触过石油烟雾的受试者在补充维生素 C 后，血脂参数显著降低，但高密度脂蛋白胆固醇（HDL-C）的值显著升高，P=.05。结论研究表明，职业暴露于石油烟雾与血脂异常有关。 然而，连续 60 天每天服用 100 毫克维生素 C 可改善与职业性接触石油烟雾有关的血脂异常程度。可以考虑将维生素 C 作为一种预防手段，以减轻或改善工人因职业暴露于石油烟雾和产品而导致的心血管风险。
{"title":"Vitamin C Supplementation Lowered Atherogenic Lipid Parameters among Oil and Gas Workers Occupationally Exposed to Petroleum Fumes in Port Harcourt, Rivers State, Nigeria","authors":"George-Opuda, I. M, Etuk, E.J, Elechi-Amadi, K. N, Okolonkwo, B. N, Adegoke, O. A., Ohaka, T. P., Elekima, I.","doi":"10.9734/jamps/2024/v26i3676","DOIUrl":"https://doi.org/10.9734/jamps/2024/v26i3676","url":null,"abstract":"Aim: To evaluate the effect of vitamin C supplementation on lipid profile parameters among oil and gas workers occupationally exposed to petroleum fumes through inhalation over a period of 12 months. \u0000Study Design: A total of 150 subjects between the age ranges of 18 to 45 years old were recruited for the study of which 50 subjects were exposed to petroleum fumes and were given vitamin C supplementation (group1), 50 were also exposed to petroleum without vitamin C (Group 2) and 50 subjects are non-oil and gas workers (control subjects). \u0000Methodology: The Group 1 subjects were orally administered vitamin C supplements of 100mg/day for 60 days before sample collection while Group 2 subjects exposed to petroleum fumes were not given vitamin C or took vitamin during the period of the study. The control subjects were non-oil and gas workers. At the end of the experiment (60 days), blood specimens were collected from group 1, group 2, and the control subjects. Lipid parameters such as cholesterol, triglycerides, high-density lipoprotein, low-density lipoprotein, and very low-density lipoprotein were analysed using enzymatic methods. Statistical analysis was done using GraphPad Prism and results were expressed as Mean±SD. \u0000Results: The results indicated significantly higher values in total cholesterol, triglyceride, low-density lipoprotein, and very low-density lipoprotein in the petroleum fumes exposed subjects compared to control subjects except for high-density lipoprotein which indicated significantly lower values. When those exposed were given vitamin C supplementation, there was a significant reduction in the lipid parameters except HDL-C which indicated a significantly higher value compared with those exposed without vitamin C supplementation administered orally at 100mg for 60 days at P=.05. \u0000Conclusion: The study has shown that occupational exposure to petroleum fumes is associated with dyslipidaemia. However, the use of 100mg of vitamin C daily for 60 days ameliorated the degree of dyslipidaemia associated with occupational exposure to petroleum fumes. Vitamin C could be considered as a preventive means to mitigate or ameliorate cardiovascular risks due to occupational exposure to petroleum fumes and products among workers.","PeriodicalId":14903,"journal":{"name":"Journal of Advances in Medical and Pharmaceutical Sciences","volume":"167 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140451828","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-02-19DOI: 10.9734/jamps/2024/v26i4677
R. Duman, A. Vurmaz
Introduction: TNF-α plays a key role in initiating pathologic angiogenesis, however, literature on the effects of infliximab on angiogenesis is limited. Objective: The study aimed to investigate the effects of infliximab on angiogenesis in an in vivo chick chorioallantoic membrane (CAM) model. Methods: The study was approved by the local ethics committee on animal experimentation. Thirty fertilized specific pathogen-free eggs were incubated and kept under appropriate temperature and humidity control. On the third day of the incubation, infliximab (1 µmol) dissolved in phosphate-buffered saline in the first group, phosphate-buffered saline (negative control) (0.1 ml) in the second group, anti-VEGF (positive control) (1 µmol) in the third group were administered by injection. On the eighth day of incubation, the vascular structures of the CAMs were macroscopically examined, and standard digital photographs were taken. The digital images were analyzed, and data including mean vessel density, thickness, and number were compared between groups. P < 0.05 was considered statistically significant. Results: Angiogenesis was significantly reduced in the anti-VEGF and infliximab groups compared to the saline-only group. Vessel thickness, vessel number, and vessel density were significantly less in the infliximab and anti-VEGF groups compared to the saline-only group (p=0.034, 0.029, 0.024, respectively). Conclusions: Infliximab showed promising antiangiogenic effects in the chick CAM model. Thus, infliximab could be a treatment agent in pathological processes in which angiogenesis is responsible. The antiangiogenic effect of infliximab could be due to the inhibition of various angiogenesis-related cytokines and adhesion molecules. Further studies are needed to clarify the exact mechanisms.
{"title":"Antiangiogenic Effects of Infliximab in Chick Chorioallantoic Membrane Model","authors":"R. Duman, A. Vurmaz","doi":"10.9734/jamps/2024/v26i4677","DOIUrl":"https://doi.org/10.9734/jamps/2024/v26i4677","url":null,"abstract":"Introduction: TNF-α plays a key role in initiating pathologic angiogenesis, however, literature on the effects of infliximab on angiogenesis is limited. \u0000Objective: The study aimed to investigate the effects of infliximab on angiogenesis in an in vivo chick chorioallantoic membrane (CAM) model. \u0000Methods: The study was approved by the local ethics committee on animal experimentation. Thirty fertilized specific pathogen-free eggs were incubated and kept under appropriate temperature and humidity control. On the third day of the incubation, infliximab (1 µmol) dissolved in phosphate-buffered saline in the first group, phosphate-buffered saline (negative control) (0.1 ml) in the second group, anti-VEGF (positive control) (1 µmol) in the third group were administered by injection. On the eighth day of incubation, the vascular structures of the CAMs were macroscopically examined, and standard digital photographs were taken. The digital images were analyzed, and data including mean vessel density, thickness, and number were compared between groups. P < 0.05 was considered statistically significant. \u0000Results: Angiogenesis was significantly reduced in the anti-VEGF and infliximab groups compared to the saline-only group. Vessel thickness, vessel number, and vessel density were significantly less in the infliximab and anti-VEGF groups compared to the saline-only group (p=0.034, 0.029, 0.024, respectively). \u0000Conclusions: Infliximab showed promising antiangiogenic effects in the chick CAM model. Thus, infliximab could be a treatment agent in pathological processes in which angiogenesis is responsible. The antiangiogenic effect of infliximab could be due to the inhibition of various angiogenesis-related cytokines and adhesion molecules. Further studies are needed to clarify the exact mechanisms.","PeriodicalId":14903,"journal":{"name":"Journal of Advances in Medical and Pharmaceutical Sciences","volume":"6 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139958845","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Background: VAP, or ventilator-associated pneumonia, is one of the most common ICU-acquired diseases and a significant cause of mortality among Intensive Care Unit patients. Infectious illnesses are currently underestimated in the South Asian Region, which has limited health resources. Objective: To examine the incidence of VAP, risk factors associated and the microbiological profile in ICU patients in tertiary care hospitals. Methods: A total of 114 patients under mechanical who satisfied all inclusion criteria were selected. Detailed history, investigations were undertaken. The diagnosis of VAP was made according to clinical and laboratory findings (as per CDC criteria) and incidence was derived from the number of patients developing VAP out of the total number of patients on ventilatory support in ICU. Results: We included 114 patients in our study. Out of 114 patients, the majority were above 70 years age group Mean age of study population was 61.29±13.42 years. Out of 114, 80 patients i.e. 70.2% were males and 34(29.8%) were females. Male: female ratio was 2.3:1. Klebsiella Pneumonia was a commonly observed organism in cultures i.e. 30.7%, followed by Pseudomonas Aeruginosa in 27.2% and Acinetobacter Baumani in 19.3%. Antibiotic sensitivity pattern of Klebsiella Pneumonia showed resistance to Carbapenemase in 20(57.1%) cases and to ESBL in 15(42.9%) cases. Death rate in our study was 17.5% Conclusion: The outcome of VAP depends on rapid identification of the causative microorganism. Empirical therapy based on knowledge of the most prevalent microorganisms and their resistance pattern has an impact on lowering morbidity and mortality, shortening the length of hospital stay, lowering of treatment expenses, and prevents the development of MDR bacteria in patients with VAP.
{"title":"Incidence, Risk Factors and Microbiological Profile of Ventilator Associated Pneumonia Patients in ICU in Tertiary Care Hospital","authors":"Anil Kumar Behera, H. Guruprasad, Shivram, Navoday, Divya, Madhusudhan Reddy, Bharadwaj, Manswini, Atahullah","doi":"10.9734/jamps/2024/v26i3675","DOIUrl":"https://doi.org/10.9734/jamps/2024/v26i3675","url":null,"abstract":"Background: VAP, or ventilator-associated pneumonia, is one of the most common ICU-acquired diseases and a significant cause of mortality among Intensive Care Unit patients. Infectious illnesses are currently underestimated in the South Asian Region, which has limited health resources. \u0000Objective: To examine the incidence of VAP, risk factors associated and the microbiological profile in ICU patients in tertiary care hospitals. \u0000Methods: A total of 114 patients under mechanical who satisfied all inclusion criteria were selected. Detailed history, investigations were undertaken. The diagnosis of VAP was made according to clinical and laboratory findings (as per CDC criteria) and incidence was derived from the number of patients developing VAP out of the total number of patients on ventilatory support in ICU. \u0000Results: We included 114 patients in our study. Out of 114 patients, the majority were above 70 years age group Mean age of study population was 61.29±13.42 years. Out of 114, 80 patients i.e. 70.2% were males and 34(29.8%) were females. Male: female ratio was 2.3:1. Klebsiella Pneumonia was a commonly observed organism in cultures i.e. 30.7%, followed by Pseudomonas Aeruginosa in 27.2% and Acinetobacter Baumani in 19.3%. Antibiotic sensitivity pattern of Klebsiella Pneumonia showed resistance to Carbapenemase in 20(57.1%) cases and to ESBL in 15(42.9%) cases. Death rate in our study was 17.5% \u0000Conclusion: The outcome of VAP depends on rapid identification of the causative microorganism. Empirical therapy based on knowledge of the most prevalent microorganisms and their resistance pattern has an impact on lowering morbidity and mortality, shortening the length of hospital stay, lowering of treatment expenses, and prevents the development of MDR bacteria in patients with VAP.","PeriodicalId":14903,"journal":{"name":"Journal of Advances in Medical and Pharmaceutical Sciences","volume":"135 21","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139780750","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Background: VAP, or ventilator-associated pneumonia, is one of the most common ICU-acquired diseases and a significant cause of mortality among Intensive Care Unit patients. Infectious illnesses are currently underestimated in the South Asian Region, which has limited health resources. Objective: To examine the incidence of VAP, risk factors associated and the microbiological profile in ICU patients in tertiary care hospitals. Methods: A total of 114 patients under mechanical who satisfied all inclusion criteria were selected. Detailed history, investigations were undertaken. The diagnosis of VAP was made according to clinical and laboratory findings (as per CDC criteria) and incidence was derived from the number of patients developing VAP out of the total number of patients on ventilatory support in ICU. Results: We included 114 patients in our study. Out of 114 patients, the majority were above 70 years age group Mean age of study population was 61.29±13.42 years. Out of 114, 80 patients i.e. 70.2% were males and 34(29.8%) were females. Male: female ratio was 2.3:1. Klebsiella Pneumonia was a commonly observed organism in cultures i.e. 30.7%, followed by Pseudomonas Aeruginosa in 27.2% and Acinetobacter Baumani in 19.3%. Antibiotic sensitivity pattern of Klebsiella Pneumonia showed resistance to Carbapenemase in 20(57.1%) cases and to ESBL in 15(42.9%) cases. Death rate in our study was 17.5% Conclusion: The outcome of VAP depends on rapid identification of the causative microorganism. Empirical therapy based on knowledge of the most prevalent microorganisms and their resistance pattern has an impact on lowering morbidity and mortality, shortening the length of hospital stay, lowering of treatment expenses, and prevents the development of MDR bacteria in patients with VAP.
{"title":"Incidence, Risk Factors and Microbiological Profile of Ventilator Associated Pneumonia Patients in ICU in Tertiary Care Hospital","authors":"Anil Kumar Behera, H. Guruprasad, Shivram, Navoday, Divya, Madhusudhan Reddy, Bharadwaj, Manswini, Atahullah","doi":"10.9734/jamps/2024/v26i3675","DOIUrl":"https://doi.org/10.9734/jamps/2024/v26i3675","url":null,"abstract":"Background: VAP, or ventilator-associated pneumonia, is one of the most common ICU-acquired diseases and a significant cause of mortality among Intensive Care Unit patients. Infectious illnesses are currently underestimated in the South Asian Region, which has limited health resources. \u0000Objective: To examine the incidence of VAP, risk factors associated and the microbiological profile in ICU patients in tertiary care hospitals. \u0000Methods: A total of 114 patients under mechanical who satisfied all inclusion criteria were selected. Detailed history, investigations were undertaken. The diagnosis of VAP was made according to clinical and laboratory findings (as per CDC criteria) and incidence was derived from the number of patients developing VAP out of the total number of patients on ventilatory support in ICU. \u0000Results: We included 114 patients in our study. Out of 114 patients, the majority were above 70 years age group Mean age of study population was 61.29±13.42 years. Out of 114, 80 patients i.e. 70.2% were males and 34(29.8%) were females. Male: female ratio was 2.3:1. Klebsiella Pneumonia was a commonly observed organism in cultures i.e. 30.7%, followed by Pseudomonas Aeruginosa in 27.2% and Acinetobacter Baumani in 19.3%. Antibiotic sensitivity pattern of Klebsiella Pneumonia showed resistance to Carbapenemase in 20(57.1%) cases and to ESBL in 15(42.9%) cases. Death rate in our study was 17.5% \u0000Conclusion: The outcome of VAP depends on rapid identification of the causative microorganism. Empirical therapy based on knowledge of the most prevalent microorganisms and their resistance pattern has an impact on lowering morbidity and mortality, shortening the length of hospital stay, lowering of treatment expenses, and prevents the development of MDR bacteria in patients with VAP.","PeriodicalId":14903,"journal":{"name":"Journal of Advances in Medical and Pharmaceutical Sciences","volume":"47 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139840511","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-01-31DOI: 10.9734/jamps/2024/v26i3674
Mas’-ûd Hayatou, Bayaga Herve, L. Abongwa, E. Tembe, Njinkio Nono Borgia, C. Fokunang
Guiera senegalensis is a plant of the Combretaceae family, found in West Africa and Central Africa. It has many properties such as antibacterial, antifungal, anticancer, antioxidants, which are the subject of this study. The objective of this study was to realize a qualitative and quantitative phytochemical screening, evaluation of the antioxidant activity of the plant leaf extracts. Plant extractions was done in accordance with the methods described by Fonmboh and collaborators on the leaves of the plant; a qualitative phytochemical screening according to the methods described by Shaik and al quantitative phytochemical screening consisting of colorimetric dosage and finally the antioxidant activity was explored in-vitro by the Folin-Ciocalteu method and by the phosphomolybdenum method. This study revealed the presence of primary metabolites such as carbohydrates and proteins but also secondary metabolites such as alkaloids, flavonoids and coumarins. Quantification analysis demonstrated a significant concentration of these metabolites depending on the extract. Carbohydrates, proteins and polyphenols had a higher concentration in the hydro-ehtanolic extract with concentrations of 45,38 ± 1,88, 1172,31 ± 17,59, 310,27 ± 11,83 µg/ml respectively. Flavonoids, flavonols and alkaloids in the Aqueous maceration extract with concentrations of 145,84 ± 8,34, 169,52 ± 10,13, 320,56 ± 67,52 µg/ml. and Tannins in decoction extract with a concentration of 338,55 ± 12,25 µg/ml. The in-vitro antioxidant activity demonstrated an inhibition percentage of the order of 70.96 ± 0.58% in the extract obtained by hydro-ethanolic maceration. This study confirms the use of the plant in category 1 traditional medicine, and results show a promising potential for developing a category 2 phytomedicine. Future studies should explore the use of phytochemical compounds involved in this antioxidant activity as well as its mechanism.
{"title":"Phytochemical and In-vitro Antioxidant Activity of Guiera senegalensis (Combretaceae) Leaf Extracts","authors":"Mas’-ûd Hayatou, Bayaga Herve, L. Abongwa, E. Tembe, Njinkio Nono Borgia, C. Fokunang","doi":"10.9734/jamps/2024/v26i3674","DOIUrl":"https://doi.org/10.9734/jamps/2024/v26i3674","url":null,"abstract":"Guiera senegalensis is a plant of the Combretaceae family, found in West Africa and Central Africa. It has many properties such as antibacterial, antifungal, anticancer, antioxidants, which are the subject of this study. The objective of this study was to realize a qualitative and quantitative phytochemical screening, evaluation of the antioxidant activity of the plant leaf extracts. Plant extractions was done in accordance with the methods described by Fonmboh and collaborators on the leaves of the plant; a qualitative phytochemical screening according to the methods described by Shaik and al quantitative phytochemical screening consisting of colorimetric dosage and finally the antioxidant activity was explored in-vitro by the Folin-Ciocalteu method and by the phosphomolybdenum method. This study revealed the presence of primary metabolites such as carbohydrates and proteins but also secondary metabolites such as alkaloids, flavonoids and coumarins. Quantification analysis demonstrated a significant concentration of these metabolites depending on the extract. Carbohydrates, proteins and polyphenols had a higher concentration in the hydro-ehtanolic extract with concentrations of 45,38 ± 1,88, 1172,31 ± 17,59, 310,27 ± 11,83 µg/ml respectively. Flavonoids, flavonols and alkaloids in the Aqueous maceration extract with concentrations of 145,84 ± 8,34, 169,52 ± 10,13, 320,56 ± 67,52 µg/ml. and Tannins in decoction extract with a concentration of 338,55 ± 12,25 µg/ml. The in-vitro antioxidant activity demonstrated an inhibition percentage of the order of 70.96 ± 0.58% in the extract obtained by hydro-ethanolic maceration. This study confirms the use of the plant in category 1 traditional medicine, and results show a promising potential for developing a category 2 phytomedicine. Future studies should explore the use of phytochemical compounds involved in this antioxidant activity as well as its mechanism.","PeriodicalId":14903,"journal":{"name":"Journal of Advances in Medical and Pharmaceutical Sciences","volume":"218 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140473611","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-01-29DOI: 10.9734/jamps/2024/v26i3673
Bayaga Herve, T. Estella, Njinkio Nono Borgia Legrand, Ngameni Bathélémy, Fokunang Charles
Background: Infections are recurrent in the presence of external skin lesions and significantly complicate the healing process. Plant extracts are used in the management of these complications. Objective: This study was aimed to evaluate the phytochemical composition and the in vitro antimicrobial activity of crude extracts of four Cameroonian medicinal plants. Methods: Primary and secondary metabolites were sought and quantified in the different aqueous and hydroethanolic extracts of these different plants through colorimetric tests and spectrophotometric assays. Determination of the Minimum Inhibitory Concentration by Broth dilution methods were used to test the antimicrobial activity of different extracts of Musa paradisiaca, Ficus exasperata, Dacryodes edulis and Citrullus lanatus against five reference bacterial strains: Shigella flexneri, Pseudomonas aeroginosa; Staphylococcus aureus; Klebsiela pneumonia, Eschericha coli and three fungal isolates: Candida Albicans; Candida parapsilosis; Candida glabrata. Results: Alkaloids, polyphenols (flavonoids, coumarins, total tannins), carbohydrates and total proteins were present in the different plant extracts with varying levels from one plant to another and from one extract to another. However, the D. edulis extracts had the highest levels overall. All the extracts tested inhibited the visible growth of one of the bacterial or fungal strains used, with MIC values between 1.565 and 25 mg/mL for bacterial strains and equal to 25 mg/mL for fungal isolates. The MIC values obtained with the reference molecules were between 0.015 and 0.0625 µg/mL and 0.0765 and 0.306 µg/mL respectively for Ciprofloxacin and Fluconazole. Conclusion: This study indicates clear evidence supporting the traditional use of M. paradisiaca, F. exasperata, D. edulis and C. lanatus in treating skin and wound infections related to bacterial and fungal.
背景：外部皮肤损伤时，感染会反复发生，并使愈合过程大大复杂化。植物提取物可用于治疗这些并发症。研究目的本研究旨在评估四种喀麦隆药用植物粗提取物的植物化学成分和体外抗菌活性。方法：通过比色试验和分光光度测定法，对这些不同植物的不同水提取物和水乙醇提取物中的初级和次级代谢物进行研究和定量。采用肉汤稀释法测定最低抑菌浓度，以检验麝香草、榕树、大戟和瓜的不同提取物对五种参考细菌菌株的抗菌活性：志贺氏菌、铜绿假单胞菌、金黄色葡萄球菌、肺炎克雷伯氏菌、大肠埃希氏菌和三种真菌分离物：白色念珠菌、副丝状念珠菌和光滑念珠菌。研究结果不同植物提取物中含有生物碱、多酚（黄酮类、香豆素、总鞣质）、碳水化合物和总蛋白质，不同植物和不同提取物中的含量各不相同。不过，D. edulis 提取物的总体含量最高。所有测试的提取物都能抑制一种细菌或真菌菌株的可见生长，细菌菌株的 MIC 值在 1.565 至 25 毫克/毫升之间，真菌分离物的 MIC 值等于 25 毫克/毫升。环丙沙星和氟康唑的 MIC 值分别为 0.015 和 0.0625 微克/毫升，0.0765 和 0.306 微克/毫升。结论这项研究表明，有明确的证据支持传统上使用 M.paradisiaca、F. exasperata、D. edulis 和 C. lanatus 治疗与细菌和真菌有关的皮肤和伤口感染。
{"title":"Phytochemical Screening and In vitro Antimicrobial Activity of Four Cameroonian Medicinal Plant Extracts against Bacterial and Fungal Strains Involved in Skin Lesion Infections","authors":"Bayaga Herve, T. Estella, Njinkio Nono Borgia Legrand, Ngameni Bathélémy, Fokunang Charles","doi":"10.9734/jamps/2024/v26i3673","DOIUrl":"https://doi.org/10.9734/jamps/2024/v26i3673","url":null,"abstract":"Background: Infections are recurrent in the presence of external skin lesions and significantly complicate the healing process. Plant extracts are used in the management of these complications. \u0000Objective: This study was aimed to evaluate the phytochemical composition and the in vitro antimicrobial activity of crude extracts of four Cameroonian medicinal plants. \u0000Methods: Primary and secondary metabolites were sought and quantified in the different aqueous and hydroethanolic extracts of these different plants through colorimetric tests and spectrophotometric assays. Determination of the Minimum Inhibitory Concentration by Broth dilution methods were used to test the antimicrobial activity of different extracts of Musa paradisiaca, Ficus exasperata, Dacryodes edulis and Citrullus lanatus against five reference bacterial strains: Shigella flexneri, Pseudomonas aeroginosa; Staphylococcus aureus; Klebsiela pneumonia, Eschericha coli and three fungal isolates: Candida Albicans; Candida parapsilosis; Candida glabrata. \u0000Results: Alkaloids, polyphenols (flavonoids, coumarins, total tannins), carbohydrates and total proteins were present in the different plant extracts with varying levels from one plant to another and from one extract to another. However, the D. edulis extracts had the highest levels overall. All the extracts tested inhibited the visible growth of one of the bacterial or fungal strains used, with MIC values between 1.565 and 25 mg/mL for bacterial strains and equal to 25 mg/mL for fungal isolates. The MIC values obtained with the reference molecules were between 0.015 and 0.0625 µg/mL and 0.0765 and 0.306 µg/mL respectively for Ciprofloxacin and Fluconazole. \u0000Conclusion: This study indicates clear evidence supporting the traditional use of M. paradisiaca, F. exasperata, D. edulis and C. lanatus in treating skin and wound infections related to bacterial and fungal.","PeriodicalId":14903,"journal":{"name":"Journal of Advances in Medical and Pharmaceutical Sciences","volume":"31 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140489531","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Background: Coagulation disorders are common in patients with Human Immunodeficiency virus (HIV). Coagulation abnormalities occur as a result of HIV-related thrombocytopenia, induced hepatotoxicity due to highly active antiretroviral therapy (HAART) that impairs liver function and diminishes the function and synthesis of coagulation factors. The aim of this study was to evaluate prothrombin time (PT), activated partial thromboplastin time (APTT), platelet count, mean platelet volume, plateletcrit and platelet distribution width in HAART-naïve HIV infected patients, HAART treated and HIV-seronegative controls. Place and Duration of Study: Department of Haematology and antiretroviraltherapies (ART) clinic both of Enugu State University of Science and Technology Teaching Hospital, between March and June 2023. Methodology: A total of 150 study participants, consisting of 50 HAART-naïve HIV-infected subjects, 50 HIV-infected subjects who were taking HAART, and 50 HIV-seronegative apparently healthy subjects, were included. Coagulation tests such as PT, APTT were determined by manual procedures. Platelet counts (PC), mean platelet volume (MPV), plateletcrit (PCT), platelet distribution width (PDW) were analyzed by Mindray/BC-5150 automated analyzer. The data were analyzed using SPSS version 21. Analysis of variance (ANOVA) and Pearson correlation analysis were used. P-Value < 0.05 was considered as statistically significant. Results: Mild thrombocytopenia (100-<150 x 109/L) was found in 48% of HIV-infected subjects who were taking HAART, 76% mild thrombocytopenia and 24% moderate thrombocytopenia (50-<100 x109/L) was found in HAART-naïve HIV-infected subjects, but no thrombocytopenia was found in apparently healthy HIV-seronegative control. Prothrombin time and APTT were significantly higher, whereas PC and PDW was significantly lower in HIV-infected subjects (both who were taking HAART and HAART-naïve) than HIV-seronegative subjects (p<0.05). Prothrombin time and APTT were significantly higher, and PC was significantly lower in HAART-naïve HIV-infected subjects than HIV-infected subjects who were taking HAART. In Pearson correlation analysis, PT and APTT has shown a significant negative correlation with a PC in those taking HAART and HAART-naïve HIV-infected subjects, whereas significant positive correlation was found in HIV-seronegative subjects. Conclusion: Prothrombin time and APTT significantly increased, whereas platelet count and PDW significantly decreased in HIV-infected subjects who were taking HAART and HAART-naïve. Basic coagulation parameters need to be monitored regularly in HIV-infected subjects in Enugu.
背景：凝血功能障碍是人类免疫缺陷病毒（HIV）患者的常见病。凝血异常的发生与 HIV 相关的血小板减少症、高活性抗逆转录病毒疗法（HAART）引起的肝毒性有关，HAART 会损害肝功能并降低凝血因子的功能和合成。本研究旨在评估 HAART 病毒感染者、HAART 治疗者和 HIV 阴性对照者的凝血酶原时间（PT）、活化部分凝血活酶时间（APTT）、血小板计数、平均血小板体积、血小板压积和血小板分布宽度。研究地点和时间：埃努古州立科技大学教学医院血液科和抗逆转录病毒疗法（ART）诊所，2023 年 3 月至 6 月。研究方法：共纳入 150 名研究对象，包括 50 名 HAART（抗逆转录病毒疗法）无效的 HIV 感染者、50 名正在服用 HAART（抗逆转录病毒疗法）的 HIV 感染者和 50 名 HIV 阴性的表面健康者。PT、APTT 等凝血测试均采用人工方法测定。血小板计数（PC）、平均血小板体积（MPV）、血小板比容（PCT）、血小板分布宽度（PDW）由 Mindray/BC-5150 自动分析仪分析。数据使用 SPSS 21 版进行分析。采用方差分析（ANOVA）和皮尔逊相关分析。P 值小于 0.05 视为具有统计学意义。结果48%正在接受 HAART 治疗的 HIV 感染者出现轻度血小板减少（100-<150 x109/L），76% HAART 治疗无效的 HIV 感染者出现轻度血小板减少，24%出现中度血小板减少（50-<100 x109/L），但在表面健康的 HIV 阴性对照组中未发现血小板减少。艾滋病病毒感染者（包括服用 HAART 和 HAART-naïve）的凝血酶原时间和 APTT 明显高于艾滋病病毒阴性对照组，而 PC 和 PDW 则明显低于艾滋病病毒阴性对照组（P<0.05）。与服用 HAART 的 HIV 感染者相比，HAART-naïve HIV 感染者的凝血酶原时间和 APTT 明显较高，PC 明显较低。在皮尔逊相关分析中，PT 和 APTT 与 PC 在接受 HAART 治疗和 HAART 治疗无效的 HIV 感染者中呈显著负相关，而在 HIV 阴性受试者中则呈显著正相关。结论在接受 HAART 治疗和 HAART 治疗无效的 HIV 感染者中，凝血酶原时间和 APTT 明显增加，而血小板计数和 PDW 则明显减少。需要定期监测埃努古地区 HIV 感染者的基本凝血参数。
{"title":"Evaluation of First-Line Coagulation Tests in Highly Active Antiretroviral Therapy (HAART) Naïve and Treated Group of HIV Infected Subjects","authors":"Ngwu Amauche Martina, Ozoemena Chiadikobi Lawrence, Umeh Okechukwu Elijah, U. Basil, Ozoume Chibuike Innocent","doi":"10.9734/jamps/2024/v26i3672","DOIUrl":"https://doi.org/10.9734/jamps/2024/v26i3672","url":null,"abstract":"Background: Coagulation disorders are common in patients with Human Immunodeficiency virus (HIV). Coagulation abnormalities occur as a result of HIV-related thrombocytopenia, induced hepatotoxicity due to highly active antiretroviral therapy (HAART) that impairs liver function and diminishes the function and synthesis of coagulation factors. The aim of this study was to evaluate prothrombin time (PT), activated partial thromboplastin time (APTT), platelet count, mean platelet volume, plateletcrit and platelet distribution width in HAART-naïve HIV infected patients, HAART treated and HIV-seronegative controls. \u0000Place and Duration of Study: Department of Haematology and antiretroviraltherapies (ART) clinic both of Enugu State University of Science and Technology Teaching Hospital, between March and June 2023. \u0000Methodology: A total of 150 study participants, consisting of 50 HAART-naïve HIV-infected subjects, 50 HIV-infected subjects who were taking HAART, and 50 HIV-seronegative apparently healthy subjects, were included. Coagulation tests such as PT, APTT were determined by manual procedures. Platelet counts (PC), mean platelet volume (MPV), plateletcrit (PCT), platelet distribution width (PDW) were analyzed by Mindray/BC-5150 automated analyzer. The data were analyzed using SPSS version 21. Analysis of variance (ANOVA) and Pearson correlation analysis were used. P-Value < 0.05 was considered as statistically significant. \u0000Results: Mild thrombocytopenia (100-<150 x 109/L) was found in 48% of HIV-infected subjects who were taking HAART, 76% mild thrombocytopenia and 24% moderate thrombocytopenia (50-<100 x109/L) was found in HAART-naïve HIV-infected subjects, but no thrombocytopenia was found in apparently healthy HIV-seronegative control. Prothrombin time and APTT were significantly higher, whereas PC and PDW was significantly lower in HIV-infected subjects (both who were taking HAART and HAART-naïve) than HIV-seronegative subjects (p<0.05). Prothrombin time and APTT were significantly higher, and PC was significantly lower in HAART-naïve HIV-infected subjects than HIV-infected subjects who were taking HAART. In Pearson correlation analysis, PT and APTT has shown a significant negative correlation with a PC in those taking HAART and HAART-naïve HIV-infected subjects, whereas significant positive correlation was found in HIV-seronegative subjects. \u0000Conclusion: Prothrombin time and APTT significantly increased, whereas platelet count and PDW significantly decreased in HIV-infected subjects who were taking HAART and HAART-naïve. Basic coagulation parameters need to be monitored regularly in HIV-infected subjects in Enugu.","PeriodicalId":14903,"journal":{"name":"Journal of Advances in Medical and Pharmaceutical Sciences","volume":"2 5","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139597845","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-01-23DOI: 10.9734/jamps/2024/v26i2671
H. A. Khaqan, Muhammad Ali Haider, Hasnain Muhammad Buksh, Hafiz Ateeq ur Rehman, R. Naz, L. Hassan
Objective: The objective is to find out the preferred surgical approach of retinal surgeons from different part of the world for the management of rhegmatogenous retinal detachment. Materials and Methods: We did a survey via a questionnaire regarding the management of rhegmatogenous retinal detachment whether retinal surgeons prefer scleral buckling or pars plana vitrectomy for rhegmatogenous retinal detachment. This survey included 109 retinal surgeons from 18 different countries across the world. Results: Out of 109 surgeons, 91.7% surgeons perform scleral buckling. The monthly number of buckling surgeries was 5 or less than 5 for 68.8% retinal surgeons while 22% said that they do more than 5 scleral buckling. Scleral buckling was the procedure of choice for 85.3% surgeons if a detachment fits in for the criteria of buckling. In comparison of buckling, vitrectomy was preferred by 66% retinal surgeons while 41.3% surgeons said that they would perform scleral buckling. The number of vitrectomies was 5 or less than 5 for 28.4% retinal surgeons, 17.4% do more than 5 while 33% do not perform vitrectomy. The number of vitrectomies per month for all sort of rhegmatogenous retinal detachment was 5 or less than 5 by 75.2% surgeons while more than 5 vitrectomies was done by 7.3% surgeons. Conclusion: In this study we concluded that most of the retinal surgeons prefer scleral buckling as the procedure of choice for rhegmatogenous retinal detachment than vitrectomy as it gives a higher anatomical success rate with less pre- and post-operative complications.
{"title":"Scleral Buckling VS Pars Plana Vitrectomy: World's Perspective","authors":"H. A. Khaqan, Muhammad Ali Haider, Hasnain Muhammad Buksh, Hafiz Ateeq ur Rehman, R. Naz, L. Hassan","doi":"10.9734/jamps/2024/v26i2671","DOIUrl":"https://doi.org/10.9734/jamps/2024/v26i2671","url":null,"abstract":"Objective: The objective is to find out the preferred surgical approach of retinal surgeons from different part of the world for the management of rhegmatogenous retinal detachment. \u0000Materials and Methods: We did a survey via a questionnaire regarding the management of rhegmatogenous retinal detachment whether retinal surgeons prefer scleral buckling or pars plana vitrectomy for rhegmatogenous retinal detachment. This survey included 109 retinal surgeons from 18 different countries across the world. \u0000Results: Out of 109 surgeons, 91.7% surgeons perform scleral buckling. The monthly number of buckling surgeries was 5 or less than 5 for 68.8% retinal surgeons while 22% said that they do more than 5 scleral buckling. Scleral buckling was the procedure of choice for 85.3% surgeons if a detachment fits in for the criteria of buckling. In comparison of buckling, vitrectomy was preferred by 66% retinal surgeons while 41.3% surgeons said that they would perform scleral buckling. The number of vitrectomies was 5 or less than 5 for 28.4% retinal surgeons, 17.4% do more than 5 while 33% do not perform vitrectomy. The number of vitrectomies per month for all sort of rhegmatogenous retinal detachment was 5 or less than 5 by 75.2% surgeons while more than 5 vitrectomies was done by 7.3% surgeons. \u0000Conclusion: In this study we concluded that most of the retinal surgeons prefer scleral buckling as the procedure of choice for rhegmatogenous retinal detachment than vitrectomy as it gives a higher anatomical success rate with less pre- and post-operative complications.","PeriodicalId":14903,"journal":{"name":"Journal of Advances in Medical and Pharmaceutical Sciences","volume":"67 11","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139604104","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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