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Study of EGCG composite hydrogel for the treatment of radiation-induced skin injuries. EGCG 复合水凝胶治疗辐射引起的皮肤损伤的研究。
IF 2.5 4区 医学 Q2 Biochemistry, Genetics and Molecular Biology Pub Date : 2023-01-01 DOI: 10.1177/22808000231218996
Jingying Wang, Lin Gao, Jianbo Song, Sijin Li

With the rising incidence of cancer, radiotherapy has become an increasingly popular treatment modality. However, radiation-induced skin injuries (RSIs) have emerged as a commonly reported side effect of radiotherapy, thereby presenting a significant challenge in the field of radiotherapy. In this study, we report the successful synthesis of a photosensitive hydrogel via amide reaction for grafting the photosensitive group, methacrylate anhydride (MA), onto chitosan (CHI) and gelatin (GEL), with subsequent physical incorporation of epigallocatechin gallate (EGCG). The resulting composite photosensitive hydrogels exhibited favorable swelling properties, rheological properties, and biocompatibility, which promote angiogenesis and demonstrate notable therapeutic efficacy against RSIs. These findings provide valuable insights into the clinical utility of EGCG composite hydrogels for the effective management of RSIs.

随着癌症发病率的上升,放射治疗已成为一种日益流行的治疗方式。然而,放疗引起的皮肤损伤(RSIs)已成为放疗的常见副作用,从而给放疗领域带来了巨大挑战。在这项研究中,我们报告了通过酰胺反应将光敏基团甲基丙烯酸甲酯酐(MA)接枝到壳聚糖(CHI)和明胶(GEL)上,并在其中加入表没食子儿茶素没食子酸酯(EGCG),从而成功合成了一种光敏水凝胶。由此产生的复合光敏水凝胶具有良好的溶胀特性、流变特性和生物相容性,可促进血管生成,对 RSI 具有显著疗效。这些发现为 EGCG 复合水凝胶有效治疗 RSI 的临床应用提供了宝贵的见解。
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引用次数: 0
Anti-fungal efficacy of Miswak Extract (Salvadora Persica) and commercial cleaner against Candida albicans on heat cured polymethylmethacrylate denture base. Miswak 提取物(Salvadora Persica)和商用清洁剂对热固化聚甲基丙烯酸甲酯义齿基托上白色念珠菌的抗真菌功效。
IF 2.5 4区 医学 Q2 Biochemistry, Genetics and Molecular Biology Pub Date : 2023-01-01 DOI: 10.1177/22808000231165666
Nadia Wajdan, Kashif Aslam, Rafat Amin, Sadaf Khan, Naseer Ahmed, Abhishek Lal, Eman M AlHamdan, Fahim Vohra, Tariq Abduljabbar, Artak Heboyan

Aim: The aim of the study was to compare the antifungal efficacy between commercial cleaner (Corega) and Miswak extract (Salvadora persica) against Candida albicans on heat cured Polymethyl methacrylate (PMMA) acrylic denture base resin.

Materials and methods: Forty-eight samples of heat cured PMMA acrylic denture base resin were fabircated in the study. The sterile acrylic resin specimens were immersed in standardized cell suspension of Candida albicans and incubated for 60 min at 370°C for cell adhesion and 2 h at 370°C for biofilm formation. After 24 h biofilm was evaluated by cell viability (CFUs) on SDA and cell counting of Candida albicans under light microscope at 400× magnification. The fungicidal effect of commercial cleaner and Miswak extract on Candida albicans biofilm was then evaluated by colony-forming units on SDA and cell counting under light microscope at 400× magnification.

Results: Screening test agar disk-diffusion assay showed mean inhibitory zone of 3 mm for commercial cleaner as compared to Miswak extract, which showed mean inhibitory zone of 2 and 1 mm for different concentrations. Broth microdilution method showed 31 mg/ml MIC and 62.5 mg/ml Minimal Fungicidal Concentration (MFC) values for commercial cleaner as compared to Miswak extract that showed 125 mg/ml MIC and 250 mg/ml MFC values against Candida albicans. A significant difference (p < 0.05) was observed between pre and post treatment of both commercial cleaner and Miswak extract, for CFUs and cell count for Candida albicans.

Conclusion: Commercial denture cleaner (Corega) showed better antifungal (C albicans) activity than Miswak extract (Salvadora persica) on heat cured PMMA acrylic denture base resin.

目的:本研究旨在比较商用清洁剂(Corega)和 Miswak 提取物(Salvadora persica)对热固化聚甲基丙烯酸甲酯(PMMA)丙烯酸义齿基托树脂上白色念珠菌的抗真菌功效:本研究共制作了 48 份热固化 PMMA 丙烯酸义齿基托树脂样本。将无菌丙烯酸树脂试样浸入白色念珠菌的标准细胞悬浮液中,在 370°C 下培养 60 分钟以检测细胞粘附情况,在 370°C 下培养 2 小时以检测生物膜形成情况。24 小时后,通过 SDA 上的细胞存活率(CFUs)和 400 倍放大镜下的白色念珠菌细胞计数对生物膜进行评估。然后,通过 SDA 上的菌落形成单位和 400 倍放大光镜下的细胞计数,评估商用清洁剂和 Miswak 提取物对白念珠菌生物膜的杀菌效果:筛选试验琼脂盘扩散法显示,商用清洁剂的平均抑制区为 3 毫米,而不同浓度的 Miswak 提取物的平均抑制区分别为 2 毫米和 1 毫米。肉汤微量稀释法显示,商用清洁剂的 MIC 值为 31 毫克/毫升,最低杀菌浓度 (MFC) 值为 62.5 毫克/毫升,而 Miswak 提取物对白色念珠菌的 MIC 值为 125 毫克/毫升,最低杀菌浓度 (MFC) 值为 250 毫克/毫升。商用清洁剂和 Miswak 提取物在处理前和处理后对白色念珠菌的 CFUs 和细胞数都有明显差异(p < 0.05):在热固化 PMMA 丙烯酸义齿基底树脂上,商用义齿清洁剂(Corega)比 Miswak 提取物(Salvadora persica)显示出更好的抗真菌(白色念珠菌)活性。
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引用次数: 0
Influence of carbon and graphene oxide nanoparticle on the adhesive properties of dentin bonding polymer: A SEM, EDX, FTIR study. 碳和氧化石墨烯纳米粒子对牙本质粘接聚合物粘接性能的影响:SEM、EDX、FTIR 研究。
IF 3.1 4区 医学 Q2 BIOPHYSICS Pub Date : 2023-01-01 DOI: 10.1177/22808000231159238
Hanan Alsunbul, Yasser F Alfawaz, Eman M Alhamdan, Imran Farooq, Fahim Vohra, Tariq Abduljabbar

Objective: This study was aimed at including 2.5 wt.% of carbon nanoparticles (CNPs) and graphene oxide NPs (GNPs) in a control adhesive (CA) and then investigate the effect of this inclusion on their mechanical properties and its adhesion to root dentin.

Materials and methods: Scanning electron microscopy and energy dispersive X-ray (SEM-EDX) mapping were conducted to investigate the structural features and elemental distribution of CNPs and GNPs, respectively. These NPs were further characterized by Raman spectroscopy. The adhesives were characterized by evaluating their push-out bond strength (PBS), rheological properties, degree of conversion (DC) investigation, and failure type analysis.

Results: The SEM micrographs revealed that the CNPs were irregular and hexagonal, whereas the GNPs were flake-shaped. EDX analysis showed that carbon (C), oxygen (O), and zirconia (Zr) were found in the CNPs, while the GNPs were composed of C and O. The Raman spectra for CNPs and GNPs revealed their characteristic bands (CNPs-D band: 1334 cm-1, GNPs-D band: 1341 cm-1, CNPs-G band: 1650 cm-1, and GNPs-G band: 1607 cm-1). The testing verified that the highest bond strength to root dentin were detected for GNP-reinforced adhesive (33.20 ± 3.55 MPa), trailed closely by CNP-reinforced adhesive (30.48 ± 3.10 MPa), while, the CA displayed lowest values (25.11 ± 3.60 MPa). The inter-group comparisons of the NP-reinforced adhesives with the CA revealed statistically significant results (p < 0.01). Failures of adhesive nature were most common in within the adhesives and root dentin. The rheological assessment results demonstrated a reduced viscosity for all the adhesives observed at advanced angular frequencies. All the adhesives verified suitable dentin interaction shown by hybrid layer and appropriate resin tag development. A reduced DC was perceived for both NP-reinforced adhesives, compared to the CA.

Conclusion: The present study's findings have demonstrated that 2.5% GNP adhesive revealed the highest, suitable root dentin interaction, and acceptable rheological properties. Nevertheless, a reduced DC was observed (matched with the CA). Prospective studies probing the influence of diverse concentrations of filler NPs on the adhesive's mechanical properties to root dentin are recommended.

研究目的本研究的目的是在对照粘合剂(CA)中加入 2.5 wt.%的碳纳米粒子(CNPs)和氧化石墨烯纳米粒子(GNPs),然后研究加入这两种纳米粒子对其机械性能及其与牙根粘合力的影响:扫描电子显微镜和能量色散 X 射线(SEM-EDX)制图分别研究了 CNPs 和 GNPs 的结构特征和元素分布。拉曼光谱对这些 NPs 做了进一步表征。粘合剂的表征方法包括评估其推出粘合强度(PBS)、流变特性、转化率(DC)调查和失效类型分析:扫描电镜显微照片显示 CNPs 呈不规则六边形,而 GNPs 则呈片状。拉曼光谱显示了 CNPs 和 GNPs 的特征带(CNPs-D 带:1334 cm-1,GNPs-D 带:1341 cm-1,CNPs-G 带:1650 cm-1,GNPs-G 带:1607 cm-1)。测试证实,GNP 增强型粘合剂与牙根的粘合强度最高(33.20 ± 3.55 兆帕),CNP 增强型粘合剂紧随其后(30.48 ± 3.10 兆帕),而 CA 粘合剂的粘合强度值最低(25.11 ± 3.60 兆帕)。NP 增强型粘合剂与 CA 的组间比较显示出具有统计学意义的结果(p 结论:NP 增强型粘合剂与 CA 的组间比较显示出具有统计学意义的结果:本研究结果表明,2.5% GNP 粘合剂显示出最高的、合适的根牙本质相互作用和可接受的流变特性。尽管如此,还是观察到了较低的直流电(与 CA 相匹配)。建议进行前瞻性研究,探讨不同浓度的填充 NP 对粘合剂与牙根的机械性能的影响。
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引用次数: 0
Bovine hydroxyapatite-based scaffold accelerated the inflammatory phase and bone growth in rats with bone defect. 牛羟基磷灰石支架促进骨缺损大鼠炎症期和骨生长。
IF 2.5 4区 医学 Q2 Biochemistry, Genetics and Molecular Biology Pub Date : 2023-01-01 DOI: 10.1177/22808000221149193
Maria Apriliani Gani, Aniek Setiya Budiatin, Dewi Wara Shinta, Chrismawan Ardianto, Junaidi Khotib

Hydroxyapatite (HA) is a biomaterial widely used to treat bone defect, such as due to traffic accident. The HA scaffold is obtained from synthetic HA or natural sources, such as bovine hydroxyapatite (BHA). This study aims to compare the characteristics and in vivo performance of BHA-based and HA-based scaffolds. For this purpose, the scaffold was formulated with gelatin (GEL) and characterised by SEM-EDX, FTIR and mini autograph. The defect model was carried out on the femur area of Wistar rats classified into three animal groups: defect, HA-GEL and BHA-GEL. Postoperatively (7, 14 and 28 days), the bone was radiologically evaluated, and stained with haematoxylin-eosin, anti-CD80 and anti-CD163. The BHA-GEL scaffold showed a regular surface and spherical particle shape, whereas the HA-GEL scaffold exhibited irregular surface. The BHA-GEL scaffold had higher pore size and compressive strength and lower calcium-to-phosphorus ratio than the HA-GEL scaffold. In vivo study showed that the expression of CD80 in the three experimental groups was not significantly different. However, the expression of CD163 differed significantly between the groups. The BHA-GEL group showed robust expression of CD163 on day 7, which rapidly decreased over time. It also showed increased osteoclasts, osteoblasts and osteocytes cell count that contributed to the integrity of the defect area. In conclusion, the BHA-based scaffold exhibited the desired physical and chemical characteristics that benefit in vivo performance versus the HA-based scaffold. Thus, the BHA-based scaffold may be used as a bone graft.

羟基磷灰石(Hydroxyapatite, HA)是一种广泛用于治疗交通事故等骨缺损的生物材料。透明质酸支架可从合成透明质酸或天然来源获得,如牛羟基磷灰石(BHA)。本研究旨在比较bha基支架和ha基支架的特点和体内性能。为此,支架用明胶(GEL)配制,并通过SEM-EDX, FTIR和迷你签名进行表征。在Wistar大鼠股骨区域建立缺损模型,分为缺损组、HA-GEL组和BHA-GEL组。术后(7天、14天和28天)对骨进行放射学评估,并用血红素-伊红染色、抗cd80和抗cd163染色。BHA-GEL支架表面呈规则形状,颗粒呈球形,而HA-GEL支架表面呈不规则形状。与HA-GEL支架相比,BHA-GEL支架的孔径和抗压强度更高,钙磷比更低。体内研究表明,CD80在三个实验组中的表达无显著差异。然而,CD163的表达在两组之间存在显著差异。BHA-GEL组在第7天表现出强烈的CD163表达,随着时间的推移迅速下降。它还显示破骨细胞、成骨细胞和骨细胞数量的增加有助于缺损区域的完整性。总之,与ha基支架相比,bha基支架表现出所需的物理和化学特性,有利于体内性能。因此,基于bha的支架可以用作骨移植。
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引用次数: 1
Evaluation of the biocompatibility of fish skin collagen with the mesenchymal stem cells in in vitro cultures. 评估鱼皮胶原与间充质干细胞在体外培养中的生物相容性。
IF 2.5 4区 医学 Q2 Biochemistry, Genetics and Molecular Biology Pub Date : 2023-01-01 DOI: 10.1177/22808000231211423
Kinga Rusinek, Anna Słysz, Tomasz Dębski, Katarzyna Siennicka, Aleksandra Zołocińska, Justyna Miszkiewicz-Jasińska, Anna Aleksandrowicz, Zygmunt Pojda

There are scarce published data suggesting, that collagen extracted from fish skin may be an attractive alternative to mammalian-derived collagen for the in vitro cell cultures. In this study, we investigated proliferation potential and differentiation capability into osteogenic and adipogenic lineages of rat adipose-derived mesenchymal stem cells (rASCs) and human adipose-derived mesenchymal stem cells (hASCs) cultured on collagen extracted from silver carp and African sharptooth catfish skins, compared with commercially available mammalian collagen and collagen-free culture dishes. Our results revealed no significant differences between fish collagen and mammalian collagen in supporting cell viability and proliferation capacity. Fish-derived collagen is a cheap material derived from production waste, does not contain transmissible pathogens of mammalian origin, supports human cell cultures at comparable level to conventional collagen sources, and may be considered as the product of choice for the in vitro cell cultures.

已发表的数据表明,从鱼皮中提取的胶原蛋白可能是哺乳动物来源胶原蛋白的一种有吸引力的体外细胞培养替代物。在这项研究中,我们研究了大鼠脂肪间充质干细胞(rASCs)和人脂肪间充质干细胞(hASCs)在鲢鱼皮和非洲尖齿鲶鱼皮提取的胶原蛋白上与市售哺乳动物胶原蛋白和无胶原蛋白培养皿相比的增殖潜力以及向成骨系和成脂系分化的能力。结果表明,鱼胶原蛋白与哺乳动物胶原蛋白在支持细胞活力和增殖能力方面没有明显差异。鱼源性胶原蛋白是一种从生产废料中提取的廉价材料,不含哺乳动物来源的可传播病原体,对人类细胞培养的支持水平与传统胶原蛋白来源相当,可视为体外细胞培养的首选产品。
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引用次数: 0
Spin-coating of Graphene Oxide as Counter Electrode for Dye-sensitized Solar Cells in Various Dispersing Solvents 不同分散溶剂中氧化石墨烯对电极染料敏化太阳能电池的自旋镀膜
IF 2.5 4区 医学 Q2 Biochemistry, Genetics and Molecular Biology Pub Date : 2022-12-30 DOI: 10.35745/afm2022v02.04.0004
T. Wu, Wei-Ming Huang, Yu-Chi Tsao, J. Tsai
Platinum (Pt) is the most commonly used counter electrode material for DSSCs. However, as Pt is a noble metal and expensive, researchers have tried to replace the Pt counter electrode with a variety of materials. In this study, graphene oxide (GO) powders were added to solvents of different polarities as precursor solutions for the counter electrode. The solvents were deionized water, dimethylformamide, isopropanol, and chlorobenzene in descending order of polarity. The prepared GO precursor solutions were coated on the Florine doped Tin Oxide (FTO) glass substrate via spin coating, then coated substrate subjected to thermal reduction reaction to obtain reduced graphene oxide, which was used as the counter electrode of the DSSC. The photoelectric conversion efficiency (PCE) of DSSC using deionized water as the dispersing solvent was 2.70%, which was five times higher than that of DSSC using chlorobenzene.
铂(Pt)是DSSCs最常用的对电极材料。然而,由于Pt是一种昂贵的贵金属,研究人员试图用各种材料代替Pt对电极。在这项研究中,氧化石墨烯(GO)粉末被添加到不同极性的溶剂中作为对电极的前驱体溶液。溶剂极性由高到低依次为去离子水、二甲基甲酰胺、异丙醇和氯苯。将制备好的氧化石墨烯前驱体溶液通过自旋涂层涂覆在氟掺杂氧化锡(FTO)玻璃基板上,再对基板进行热还原反应得到还原氧化石墨烯,作为DSSC的对电极。以去离子水为分散溶剂的DSSC的光电转换效率(PCE)为2.70%,比以氯苯为分散溶剂的DSSC提高了5倍。
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引用次数: 0
Molecular-Dynamical Investigation of Thermomechanical Properties of Spherical Solid and Hollow Nickel Nanopowder during Laser Additive Manufacturing Process 激光增材制造过程中球形固体和空心纳米镍粉末热力学性能的分子动力学研究
IF 2.5 4区 医学 Q2 Biochemistry, Genetics and Molecular Biology Pub Date : 2022-12-30 DOI: 10.35745/afm2022v02.04.0005
Ling-Feng Lai, Yu-Chen Su, Chun-Ming Chang, Kuei-Shu Hsu, D. Lu, Jian-Ming Lu
Molecular dynamics (MD) simulation with the embedded-atom method (EAM)/alloy potential is used to investigate the property of the nanoscale hollow spherical Nickel (Ni) powder during the laser additive manufacturing (AM) process. The thermomechanical properties of the Ni nanopowder is also explored (1) at room temperature and (2) from room temperature to the melting temperature during laser AM of powder bed fusion. As a result, the optimum parameters for the laser AM process are proposed. The optimal coalescence temperature of the nanoscale hollow spherical Ni powder is in the range between 980 and 1421K, while the melting temperature is in the range between 1320 and 1470 K. The coalescence and melting temperatures are lower than the melting point of Ni (1728 K).
采用嵌入原子法(EAM)/合金电位的分子动力学(MD)模拟研究了激光增材制造(AM)过程中纳米级空心球形镍(Ni)粉末的性能。研究了纳米Ni粉末在室温和室温至熔化温度下的热力学性能。最后,提出了激光增材加工的最佳工艺参数。纳米级空心球形Ni粉末的最佳聚结温度在980 ~ 1421K之间,熔融温度在1320 ~ 1470 K之间。熔结温度和熔点均低于Ni的熔点(1728k)。
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引用次数: 0
Direct Visualization of Si and Ge Atoms by Shifting Electron Picoscopy 用移动电子显微镜直接观察Si和Ge原子
IF 2.5 4区 医学 Q2 Biochemistry, Genetics and Molecular Biology Pub Date : 2022-12-30 DOI: 10.35745/afm2022v02.04.0002
O. Kucherov
The picoscopy images of the Si/Ge(100) system were analyzed, and electron cloud densitometry of silicon is presented in this study. The picoscopy is used to distinguish Ge, Si, and other chemical elements because different atoms have different densities of electron clouds. This result is in full accordance with Kucherov's law which states that the current passed through an electron cloud is proportional to the density of the cloud. The picoscopy image has shown Si crystals, Si/Ge solid solution, and their interface as the single crystal without defects. Local deformations in crystals were investigated using methods of direct visualization of individual atoms and measuring the distance of the center of atoms from the node of the crystal lattice. Visual сrystallography becomes a new way to study applied functional materials. This is the first publication on the real structure of a silicon atom.
分析了Si/Ge(100)体系的显微镜图像,提出了硅的电子云密度测定方法。由于不同的原子具有不同密度的电子云,因此使用微镜来区分锗、硅和其他化学元素。这一结果完全符合库切罗夫定律,即通过电子云的电流与电子云的密度成正比。显微镜图像显示Si晶体、Si/Ge固溶体及其界面为无缺陷的单晶。利用原子的直接可视化和原子中心到晶格节点的距离测量方法研究了晶体中的局部变形。视觉晶体学是研究应用功能材料的一种新方法。这是关于硅原子真实结构的第一份出版物。
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引用次数: 0
Design the Separation Method and Holder for Plastic Lenses 设计塑料镜片的分离方法和支架
IF 2.5 4区 医学 Q2 Biochemistry, Genetics and Molecular Biology Pub Date : 2022-12-30 DOI: 10.35745/afm2022v02.04.0001
Nguyen Ngoc Thai, Bing Liu, Kuan-Yu Lu, Gadi Ashok Kumar Reddy, K. Lee
Plastic lenses are very fragile and scratch easily. Therefore, to remove the plastic lens from the door without causing any damage, a precise base bracket is required. This article describes a method for separating plastic lenses using a 15 KHz ultrasonic horn. In this case, EDM and servo motors are used to make micro on the base holder by adjusting the gap voltage, pulse on time, pulse off-time, and outlet water pressure. To check longitudinal vibration at 15 KHz frequencies for ultrasonic horns, perform harmonic analysis by providing 15KHz frequency as the input value. The experimental results demonstrated that the average error of machining micro-holes is 0.01025 mm by EDM. The ultrasonic horn is designed to fit with 15 KHz, after tuning the ultrasonic vibration, the total machining time is 1.25 seconds, and all the plastic lenses on the workpiece gate can break within one cycle. The quality accuracy of the plastic lens is 90.83%.
塑料镜片非常脆弱,很容易划伤。因此,为了在不造成任何损坏的情况下将塑料镜片从门上取下,需要精确的底座支架。本文介绍了一种使用15khz超声波喇叭分离塑料透镜的方法。在这种情况下,使用电火花加工和伺服电机通过调节间隙电压、脉冲接通时间、脉冲关闭时间和出水压力来实现在底座支架上的微动。为了检查超声喇叭在15KHz频率下的纵向振动,通过提供15KHz频率作为输入值进行谐波分析。实验结果表明,电火花加工微孔的平均误差为0.01025 mm。超声变幅设计配合15khz,调整超声振动后,总加工时间为1.25秒,工件浇口上的所有塑料透镜可在一个周期内全部断裂。塑料镜片的质量精度为90.83%。
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引用次数: 0
Classification of Guide Rail Block by Xception Model 用异常模型对导轨块进行分类
IF 2.5 4区 医学 Q2 Biochemistry, Genetics and Molecular Biology Pub Date : 2022-12-30 DOI: 10.35745/afm2022v02.04.0003
Jun-Jie Liao, Jing-Wei Zhang, Bing-En Liu, K. Lee
Linear guide rail blocks are used in linear slide rail accessories to scrape off oil stains in the rails, installed on the front and rear ends of the slider. They are also used in milling machines, lathes, automated machines, robotic arms, electronic instruments, and so on. At present, the industry relies on manpower to carry out the quality inspection of this rail block which is difficult to standardize. Thus, automatic and digital deep learning inspection technology is introduced for the inspection. To understand the suitability of deep learning techniques applied to the linear guide block inspection process, we adopt the convolutional neural network model architecture and use the Xception model. In model training, the training effect is improved by amplifying the image method and testing many different defects. Through the Xception model, the training accuracy is about 98.7% after 30 epochs, the validation accuracy is about 97.4%, and the test accuracy is about 91.8%.
直线导轨块是用于直线滑动导轨上刮去导轨上油污的附件,安装在滑块的前后端。它们还用于铣床、车床、自动化机械、机械臂、电子仪器等。目前行业对这种钢轨块的质量检测主要依靠人力进行,难以标准化。因此,引入了自动化和数字化深度学习检测技术进行检测。为了了解深度学习技术应用于线性导块检测过程的适用性,我们采用卷积神经网络模型架构并使用Xception模型。在模型训练中,通过放大图像的方法和检测多种缺陷来提高训练效果。通过异常模型,30次后的训练准确率约为98.7%,验证准确率约为97.4%,测试准确率约为91.8%。
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引用次数: 1
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Journal of Applied Biomaterials & Functional Materials
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