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Cnicus benedictus extract-loaded electrospun gelatin wound dressing for treating diabetic wounds: An in vitro and in vivo study. 用于治疗糖尿病伤口的含桔梗提取物的电纺明胶伤口敷料:体外和体内研究。
IF 2.5 4区 医学 Q2 BIOPHYSICS Pub Date : 2024-01-01 DOI: 10.1177/22808000241245298
Jing Zhang, Shen Shen, Shijie Zhu, Fan Jia, Jin Li, Yu Sun

In the current study, Cnicus benedictus extract was loaded into electrospun gelatin scaffolds for diabetic wound healing applications. Scaffolds were characterized in vitro by mechanical testing, cell culture assays, electron microscopy, cell migration assay, and antibacterial assay. In vivo wound healing study was performed in a rat model of diabetic wound. In vitro studies revealed fibrous architecture of our developed dressings and their anti-inflammatory properties. In addition, Cnicus benedictus extract-loaded wound dressings prevented bacterial penetration. In vivo study showed that wound size reduction, collagen deposition, and epithelial thickness were significantly greater in Cnicus benedictus extract-loaded scaffolds than other groups. Gene expression studies showed that the produced wound dressings significantly upregulated VEGF and IGF genes expression in diabetic wounds.

在目前的研究中,本草纲目提取物被载入电纺明胶支架,用于糖尿病伤口愈合。通过机械测试、细胞培养试验、电子显微镜、细胞迁移试验和抗菌试验对支架进行了体外表征。在大鼠糖尿病伤口模型中进行了体内伤口愈合研究。体外研究显示,我们开发的敷料具有纤维结构和抗炎特性。此外,敷料还能防止细菌渗透。体内研究表明,与其他组别相比,负载了蛇床子提取物的支架在伤口缩小、胶原沉积和上皮厚度方面都有显著提高。基因表达研究表明,所生产的伤口敷料能明显提高糖尿病伤口中血管内皮生长因子和 IGF 基因的表达。
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引用次数: 0
Retraction Comparison of adhesive bond strength among fiber reinforced post and core with different cementation techniques: In vitro study. 回缩 采用不同粘接技术的纤维增强骨柱和骨核的粘接强度比较:体外研究
IF 3.1 4区 医学 Q2 BIOPHYSICS Pub Date : 2024-01-01 DOI: 10.1177/22808000241273951
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引用次数: 0
Application of Aleppo pine extract for skin burn treatment. 应用阿勒颇松提取物治疗皮肤烧伤。
IF 2.5 4区 医学 Q2 BIOPHYSICS Pub Date : 2024-01-01 DOI: 10.1177/22808000241236020
Najoua Salhi, Otman El Guourrami, Abdelaali Balahbib, Lamiae Rouas, Siham Moussaid, Amina Moutawalli, Fatima Zahra Benkhouili, Mouna Ameggouz, Riaz Ullah, Amal Alotaibi, Abdelhakim Bouyahya, Ching Siang Tan, Long Chiau Ming, My El Abbes Faouzi, Yahya Cherrah

Objective: To investigate the Pinus halepensis extracts and determine its healing and antibacterial effects, and to evaluate the treatment of skin burns.

Methods: Aqueous and ethanolic extracts and topical based on Aleppo pine plant extracts were prepared. Thirty male and female Wistar rats were used to study the cutaneous toxicity of extracts from the bark of P. halepensis. The extracts' healing potential for burn wounds were also assessed by evaluating the clinical and macroscopic aspects of the wounds. The antibacterial activity of crude extracts of P. halepensis as well as its wound healing abilities was verified in this investigation.

Results: In animals with acute dermal toxicity, there were no signs of treatment-related toxicity or death. The extracts of these plants could be transformed into phytomedicines for the treatment of infected wounds. The results demonstrated that formulated ointments are successful in treating second-degree burns in rats and may be suitable for the short-term therapeutic treatment of second-degree burns.

Conclusion: This study successfully answered our problem, regarding the efficacy of our extract for treating second-degree burns in rats. Further studies are needed to confirm these results by identifying the molecules responsible for these activities and examining their mechanism of action.

目的研究欧洲赤松(Pinus halepensis)提取物,确定其愈合和抗菌效果,并评估其对皮肤烧伤的治疗效果:方法:制备水提取物、乙醇提取物和基于阿勒颇松植物提取物的外用药。用 30 只雄性和雌性 Wistar 大鼠研究阿勒颇松树皮提取物的皮肤毒性。此外,还通过评估伤口的临床和宏观方面,评估了提取物对烧伤伤口的愈合潜力。在这项研究中,验证了半枝莲粗萃取物的抗菌活性及其伤口愈合能力:结果:在急性皮肤中毒的动物中,没有出现与治疗相关的中毒或死亡迹象。这些植物的提取物可转化为治疗感染伤口的植物药。结果表明,配制的软膏能成功治疗大鼠的二度烧伤,可能适合二度烧伤的短期治疗:这项研究成功地回答了我们的问题,即我们的提取物对治疗大鼠二度烧伤的疗效。为了证实这些结果,还需要进行进一步的研究,确定这些活性的分子并研究其作用机制。
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引用次数: 0
Exploring the purity of chitin from crustacean sources using deep eutectic solvents: A machine learning approach. 利用深共晶溶剂探索甲壳素的纯度:机器学习方法。
IF 2.5 4区 医学 Q2 BIOPHYSICS Pub Date : 2024-01-01 DOI: 10.1177/22808000241248887
Sasireka Rajendran, Madheswaran Muthusamy

Objective: Chitin a natural polymer is abundant in several sources such as shells of crustaceans, mollusks, insects, and fungi. Several possible attempts have been made to recover chitin because of its importance in biomedical applications in various forms such as hydrogel, nanoparticles, nanosheets, nanowires, etc. Among them, deep eutectic solvents have gained much consideration because of their eco-friendly and recyclable nature. However, several factors need to be addressed to obtain a pure form of chitin with a high yield. The development of an innovative system for the production of quality chitin is of prime importance and is still challenging.

Methods: The present study intended to develop a novel and robust approach to investigate chitin purity from various crustacean shell wastes using deep eutectic solvents. This investigation will assist in envisaging the important influencing parameters to obtain a pure form of chitin via a machine learning approach. Different machine learning algorithms have been proposed to model chitin purity by considering the enormous experimental dataset retrieved from previously conducted experiments. Several input variables have been selected to assess chitin purity as the output variable.

Results: The statistical criteria of the proposed model have been critically investigated and it was observed that the results indicate XGBoost has the maximum predictive accuracy of 0.95 compared with other selected models. The RMSE and MAE values were also minimal in the XGBoost model. In addition, it revealed better input variables to obtain pure chitin with minimal processing time.

Conclusion: This study validates that machine learning paves the way for complex problems with substantial datasets and can be an inexpensive and time-saving model for analyzing chitin purity from crustacean shells.

目的甲壳素是一种天然聚合物,在甲壳类动物、软体动物、昆虫和真菌的外壳等多种来源中含量丰富。由于甲壳素在生物医学应用中的重要性,人们已尝试以各种形式(如水凝胶、纳米颗粒、纳米片、纳米线等)回收甲壳素。其中,深共晶溶剂因其环保和可回收的特性而备受关注。然而,要获得高产率的纯甲壳素需要解决几个因素。开发一种生产优质甲壳素的创新系统至关重要,但目前仍面临挑战:本研究旨在开发一种新颖、稳健的方法,利用深共晶溶剂从各种甲壳类贝壳废料中研究甲壳素的纯度。这项研究将有助于通过机器学习方法设想获得纯甲壳素的重要影响参数。考虑到从以前进行的实验中获取的大量实验数据集,我们提出了不同的机器学习算法,以建立甲壳素纯度模型。我们选择了几个输入变量来评估作为输出变量的甲壳素纯度:对所提模型的统计标准进行了严格研究,结果表明,与其他选定模型相比,XGBoost 的预测准确率最高,达到 0.95。XGBoost 模型的 RMSE 和 MAE 值也最小。此外,它还揭示了更好的输入变量,从而以最短的加工时间获得纯甲壳素:这项研究证明,机器学习为解决复杂问题和大量数据集铺平了道路,并且可以成为分析甲壳类动物甲壳素纯度的一种廉价省时的模型。
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引用次数: 0
Engineering VEGF-like peptide QKCMP promotes rapid endothelialization of blood vessels. 工程血管内皮生长因子样肽 QKCMP 可促进血管快速内皮化。
IF 3.1 4区 医学 Q2 BIOPHYSICS Pub Date : 2024-01-01 DOI: 10.1177/22808000241301180
Haifeng Wang, Yi Huang, Chenhui Zhou, Fanyong Gong, Jiangyong Wang, Gao Chen

Angiogenesis, which involves many essential processes, such as human reproduction, organ development, and wound healing, is regulated by multiple signaling pathways. QKCMP is a polypeptide with similar effects to vascular endothelial growth factor (VEGF), which promotes angiogenesis. In this study, zebrafish were treated with different concentrations of QKCMP, and it was found that QKCMP significantly promoted the growth of blood vessels. Human umbilical vein endothelial cells (HUVECs) was then treated with different concentrations of QKCMP, which proved that QKCMP could promote cell proliferation and inhibit cell apoptosis, and thus obtain a complete gene expression matrix. Genes and biological functions or pathways significantly associated with QKCMP were obtained using differential gene expression analysis, weighted gene co-expression network analysis (WGCNA), and enrichment analyses. Among them, genes significantly related to QKCMP are enriched in biological processes (BP) such as vascular formation and development, as well as the main signaling pathway: PI3K/AKT signaling pathway. The proproliferative and antiapoptotic effects of QKCMP on the HUVECs and the induction of cell cycle were then verified using cell counting kit 8 (CCK-8) and flow cytometry. Finally, it was confirmed that QKCMP promotes angiogenesis and rapid endothelialization by stimulating the PI3K-AKT and Hippo signaling pathways using quantitative real-time PCR (qRT-PCR) and western blot (WB).

血管生成涉及人类生殖、器官发育和伤口愈合等许多重要过程,受多种信号通路调控。QKCMP 是一种多肽,具有与血管内皮生长因子(VEGF)类似的促进血管生成的作用。本研究用不同浓度的 QKCMP 处理斑马鱼,发现 QKCMP 能显著促进血管生长。然后用不同浓度的 QKCMP 处理人脐静脉内皮细胞(HUVECs),证明 QKCMP 能促进细胞增殖和抑制细胞凋亡,从而获得完整的基因表达矩阵。通过差异基因表达分析、加权基因共表达网络分析(WGCNA)和富集分析,获得了与QKCMP显著相关的基因和生物功能或通路。其中,与 QKCMP 明显相关的基因富集于生物过程(BP),如血管形成和发育,以及主要的信号通路:PI3K/AKT 信号通路。然后,使用细胞计数试剂盒 8(CCK-8)和流式细胞术验证了 QKCMP 对 HUVEC 的增殖和抗凋亡作用以及诱导细胞周期的作用。最后,利用实时定量 PCR(qRT-PCR)和免疫印迹(WB)证实了 QKCMP 通过刺激 PI3K-AKT 和 Hippo 信号通路促进血管生成和快速内皮化。
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引用次数: 0
In vitro assessment of Momordica charantia/Hypericum perforatum oils loaded PCL/Collagen fibers: Novel scaffold for tissue engineering. 对负载 PCL/胶原纤维的 Momordica charantia/Hypericum perforatum 油进行体外评估:用于组织工程的新型支架
IF 2.5 4区 医学 Q2 BIOPHYSICS Pub Date : 2024-01-01 DOI: 10.1177/22808000231221067
Emre Fatih Ediz, Cansu Güneş, Meltem Demirel Kars, Ahmet Avcı

The research on tissue engineering applications has been progressing to manufacture ideal tissue scaffold biomaterials. In this study, a double-layered electrospun biofiber scaffold biomaterial including Polycaprolactone (PCL)/Collagen (COL) fibrous inner layer and PCL/ Momordica charantia (MC) and Hypericum perforatum (HP) oils fibrous outer layer was developed to manufacture a functional, novel tissue scaffold with the advantageous mechanical and biological properties. The main approach was to combine the natural perspective using medicinal oils with an engineering point of view to fabricate a potential functional scaffold for tissue engineering. Medicinal plants MC and HP are rich in functional oils and incorporation of them in a tissue scaffold will unveil their potential to augment both new tissue formation and wound healing. In this study, a novel double-layered scaffold prototype was fabricated using electrospinning technique with two PCL fiber layers, first is composed of collagen, and second is composed of oils extracted from medicinal plants. Initially, the composition of plant oils was analyzed. Thereafter the biofiber scaffold layers were fabricated and were evaluated in terms of morphology, physicochemistry, thermal and mechanical features, wettability, in vitro bio-degradability. Double-layered scaffold prototype was further analyzed in terms of in vitro biocompatibility and antibacterial effect. The medicinal oils blend provided antioxidant and antibacterial properties to the novel PCL/Oils layer. The results signify that inner PCL/COL layer exhibited advanced biodegradability of 8.5% compared to PCL and enhanced wettability with 11.7° contact angle. Strength of scaffold prototype was 5.98 N/mm2 thanks to the elastic PCL fibrous matrix. The double-layered functional biofiber scaffold enabled 92% viability after 72 h contact with fibroblast cells and furthermore provided feasible attachment sites for the cells. The functional scaffold prototype's noteworthy mechanical, chemical, and biological features enable it to be suggested as a different novel biomaterial with the potential to be utilized in tissue engineering applications.

为制造理想的组织支架生物材料,有关组织工程应用的研究一直在取得进展。本研究开发了一种双层电纺生物纤维支架生物材料,包括聚己内酯(PCL)/胶原蛋白(COL)纤维内层和 PCL/ Momordica charantia(MC)和金丝桃油(HP)纤维外层,以制造一种具有良好机械和生物特性的功能性新型组织支架。主要方法是将药用油脂的自然观点与工程观点相结合,为组织工程制造一种潜在的功能性支架。药用植物 MC 和 HP 含有丰富的功能性油脂,将它们融入组织支架中将会发现它们在促进新组织形成和伤口愈合方面的潜力。本研究利用电纺丝技术制造了一种新型双层支架原型,其中有两层 PCL 纤维,第一层由胶原蛋白组成,第二层由从药用植物中提取的油组成。首先分析了植物油的成分。之后,制作了生物纤维支架层,并从形态、物理化学、热和机械特性、润湿性、体外生物降解性等方面进行了评估。还进一步分析了双层支架原型的体外生物相容性和抗菌效果。药用油混合物为新型 PCL/油层提供了抗氧化和抗菌特性。结果表明,与 PCL 相比,PCL/COL 内层的生物降解性提高了 8.5%,润湿性增强,接触角为 11.7°。由于 PCL 纤维基质具有弹性,支架原型的强度为 5.98 N/mm2。在与成纤维细胞接触 72 小时后,双层功能生物纤维支架的存活率达到 92%,而且还为细胞提供了可行的附着点。该功能性支架原型具有显著的机械、化学和生物特性,因此被认为是一种新型生物材料,有望应用于组织工程领域。
{"title":"In vitro assessment of <i>Momordica charantia</i>/<i>Hypericum perforatum</i> oils loaded PCL/Collagen fibers: Novel scaffold for tissue engineering.","authors":"Emre Fatih Ediz, Cansu Güneş, Meltem Demirel Kars, Ahmet Avcı","doi":"10.1177/22808000231221067","DOIUrl":"https://doi.org/10.1177/22808000231221067","url":null,"abstract":"<p><p>The research on tissue engineering applications has been progressing to manufacture ideal tissue scaffold biomaterials. In this study, a double-layered electrospun biofiber scaffold biomaterial including Polycaprolactone (PCL)/Collagen (COL) fibrous inner layer and PCL/ <i>Momordica charantia</i> (MC) and <i>Hypericum perforatum (HP)</i> oils fibrous outer layer was developed to manufacture a functional, novel tissue scaffold with the advantageous mechanical and biological properties. The main approach was to combine the natural perspective using medicinal oils with an engineering point of view to fabricate a potential functional scaffold for tissue engineering. Medicinal plants MC and HP are rich in functional oils and incorporation of them in a tissue scaffold will unveil their potential to augment both new tissue formation and wound healing. In this study, a novel double-layered scaffold prototype was fabricated using electrospinning technique with two PCL fiber layers, first is composed of collagen, and second is composed of oils extracted from medicinal plants. Initially, the composition of plant oils was analyzed. Thereafter the biofiber scaffold layers were fabricated and were evaluated in terms of morphology, physicochemistry, thermal and mechanical features, wettability, in vitro bio-degradability. Double-layered scaffold prototype was further analyzed in terms of in vitro biocompatibility and antibacterial effect. The medicinal oils blend provided antioxidant and antibacterial properties to the novel PCL/Oils layer. The results signify that inner PCL/COL layer exhibited advanced biodegradability of 8.5% compared to PCL and enhanced wettability with 11.7° contact angle. Strength of scaffold prototype was 5.98 N/mm<sup>2</sup> thanks to the elastic PCL fibrous matrix. The double-layered functional biofiber scaffold enabled 92% viability after 72 h contact with fibroblast cells and furthermore provided feasible attachment sites for the cells. The functional scaffold prototype's noteworthy mechanical, chemical, and biological features enable it to be suggested as a different novel biomaterial with the potential to be utilized in tissue engineering applications.</p>","PeriodicalId":14985,"journal":{"name":"Journal of Applied Biomaterials & Functional Materials","volume":"22 ","pages":"22808000231221067"},"PeriodicalIF":2.5,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139466654","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Antimicrobial hard denture reliners using quaternary ammonium methacryloxy silicate (K18 QAMS) and K18-functionalized filler. 使用季铵盐甲基丙烯酰氧基硅酸盐(K18 QAMS)和 K18 功能化填料的抗菌硬义齿衬垫。
IF 3.1 4区 医学 Q2 BIOPHYSICS Pub Date : 2024-01-01 DOI: 10.1177/22808000241284431
Sara Bellusa, Lianrui Chu, Evelyn Fung, Kyumin Whang

Objective: To determine the effects of adding a quaternary ammonium methacryloxy silicate (K18) and K18-functionalized filler (K18-Filler) on the material and antimicrobial properties of a hard denture reline material.

Materials and methods: 30% K18 in methyl methacrylate (K18-MMA; 0-20 wt% of reliner) and K18-Filler (0-30 wt% of reliner) were incorporated into KoolinerTM hard denture reliner. KoolinerTM served as the control. The cure (Shore A hardness), hydrophilicity (contact angles), mechanical (3-point bend test), water sorption, and antimicrobial properties against Streptococcus mutans, S. sanguinis, and Candida albicans were determined.

Results: Most K18 groups cured well and had comparable Shore A hardness values (range ~52 to 70 DHN) to that of controls (67.2 ± 1.8 DHN; Bonferroni corrected p > 0.0003). Even the softest group had hardness values within the range of commercial products. Half of the K18 groups had comparable contact angles to that of controls (range ~75° to 80° vs 83.41° ± 2.66°; Bonferroni corrected p > 0.0003), and most were within the range of commercial liners. K18-MMA and K18-Filler increased modulus but decreased ultimate transverse strength (UTS). All experimental groups had comparable or higher moduli than controls (range ~966 to 2069 MPa vs 1340 ± 119 MPa; Bonferroni corrected p < 0.0003), but only half of the experimental groups had comparable UTS to that of controls (range ~41 to 49 MPa vs 55.8 ± 1.5 MPa; Bonferroni corrected p > 0.0003). The 15% and 20% K18-MMA with 30% K18-Filler groups had significant antimicrobial activity against all three microbes (p < 0.05). However, the 15% and 20% K18-MMA with 30% K18-Filler groups had significantly higher water sorption at early time points (p < 0.05). After 8 weeks, they were comparable to each other (p > 0.05).

Conclusions: K18-MMA and K18-Filler are promising antimicrobial additives that produce hard denture liners with material properties within the range of commercial products and significant antimicrobial properties against S. mutans, S. sanguinis, and C. albicans. Further development is needed to reduce water sorption.

目的材料和方法:在 KoolinerTM 硬义齿衬垫中加入甲基丙烯酸甲酯中 30% 的 K18(K18-MMA;衬垫的 0-20 wt%)和 K18-Filler(衬垫的 0-30 wt%)。KoolinerTM 作为对照。测定了固化(邵氏 A 硬度)、亲水性(接触角)、机械性(3 点弯曲试验)、吸水性以及对变异链球菌、血清链球菌和白色念珠菌的抗菌性:大多数 K18 组固化良好,与对照组(67.2 ± 1.8 DHN;Bonferroni 校正 p > 0.0003)的肖氏 A 硬度值(范围 ~52 至 70 DHN)相当。即使是最柔软的组别,其硬度值也在商用产品的范围之内。半数 K18 组的接触角与对照组相当(范围 ~75° 至 80° vs 83.41° ± 2.66°;Bonferroni 校正后 p > 0.0003),而且大多数组都在商用衬垫的范围内。K18-MMA 和 K18-Filler 增加了模量,但降低了极限横向强度 (UTS)。所有实验组的模量与对照组相当或更高(范围 ~966 至 2069 兆帕对比 1340 ± 119 兆帕;Bonferroni 校正 p p > 0.0003)。15% 和 20% K18-MMA 与 30% K18-Filler 组对所有三种微生物都具有显著的抗菌活性(p p > 0.05):结论:K18-MMA 和 K18-Filler 是很有前途的抗菌添加剂,它们生产的硬义齿衬垫的材料性能在商业产品范围内,对变异性酵母菌、血清酵母菌和白色念珠菌具有显著的抗菌性能。还需要进一步开发,以减少吸水性。
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引用次数: 0
Physicochemical and biocompatibility characterisation of a 3D lyophilised platelet-rich fibrin scaffold for cleft lip and palate repair. 用于唇腭裂修复的三维冻干富血小板纤维蛋白支架的物理化学和生物相容性表征。
IF 3.1 4区 医学 Q2 BIOPHYSICS Pub Date : 2024-01-01 DOI: 10.1177/22808000241289208
Nurul Aida Ngah, Jithendra Ratnayake, George J Dias, Darryl C Tong, Siti Noor Fazliah Mohd Noor, Paul R Cooper, Haizal Mohd Hussaini

Craniofacial bone defects result from various disorders such as trauma, congenital malformations and infections. Cleft lip and palate are the most prevalent congenital craniofacial birth defect in humans. Growth factors (GFs) are soluble proteins secreted by cells that regulate various cellular processes and tissue regeneration. At present, developing three-dimensional scaffolds for delivering GFs to the site of injury has become an important aspect in craniofacial bone regeneration. This study aims to develop a novel 3D bone substitute using lyophilized-platelet-rich fibrin (LyPRF) biocomposite scaffolds for potential application for CLP repair. Collagen (C), bioglass (BG), and LyPRF were used to fabricate a biocomposite (C-BG-LyPRF) scaffold. The physical, chemical, and biocompatibility properties of the scaffold were evaluated. The C-BG-LyPRF scaffold demonstrated a mean pore diameter of 146 µm within a porosity of 87.26%. The FTIR spectra verified the presence of am-ide I, II, and III functional groups. The inorganic phase of the C-BG-LyPRF scaffold was composed of sodium, calcium, silicon, and phosphorus, as determined by EDX analysis. Furthermore, C-BG-LyPRF scaffold was biocompatible with MC3T3-E1 cells in both the Live/Dead and prolif-eration assays. Data demonstrate the developed C-BG-LyPRF scaffold exhibits biomimetic and biocompatibility properties, establishing it as a promising biomaterial for craniofacial regeneration.

颅面骨骼缺陷是由各种疾病造成的,如外伤、先天畸形和感染。唇腭裂是人类最常见的先天性颅面出生缺陷。生长因子(GFs)是细胞分泌的可溶性蛋白质,可调节各种细胞过程和组织再生。目前,开发用于向损伤部位输送生长因子的三维支架已成为颅颌面骨再生的一个重要方面。本研究旨在利用冻干血小板富集纤维蛋白(LyPRF)生物复合材料支架开发一种新型三维骨替代物,有望应用于中枢神经瘫痪修复。研究人员使用胶原蛋白(C)、生物玻璃(BG)和 LyPRF 制作了一种生物复合材料(C-BG-LyPRF)支架。对支架的物理、化学和生物相容性进行了评估。C-BG-LyPRF 支架的平均孔径为 146 微米,孔隙率为 87.26%。傅立叶变换红外光谱验证了酰胺Ⅰ、Ⅱ和Ⅲ官能团的存在。经 EDX 分析测定,C-BG-LyPRF 支架的无机相由钠、钙、硅和磷组成。此外,在活/死和增殖试验中,C-BG-LyPRF 支架与 MC3T3-E1 细胞均具有生物相容性。数据表明,所开发的 C-BG-LyPRF 支架具有仿生和生物相容性,是一种很有前途的颅面再生生物材料。
{"title":"Physicochemical and biocompatibility characterisation of a 3D lyophilised platelet-rich fibrin scaffold for cleft lip and palate repair.","authors":"Nurul Aida Ngah, Jithendra Ratnayake, George J Dias, Darryl C Tong, Siti Noor Fazliah Mohd Noor, Paul R Cooper, Haizal Mohd Hussaini","doi":"10.1177/22808000241289208","DOIUrl":"https://doi.org/10.1177/22808000241289208","url":null,"abstract":"<p><p>Craniofacial bone defects result from various disorders such as trauma, congenital malformations and infections. Cleft lip and palate are the most prevalent congenital craniofacial birth defect in humans. Growth factors (GFs) are soluble proteins secreted by cells that regulate various cellular processes and tissue regeneration. At present, developing three-dimensional scaffolds for delivering GFs to the site of injury has become an important aspect in craniofacial bone regeneration. This study aims to develop a novel 3D bone substitute using lyophilized-platelet-rich fibrin (LyPRF) biocomposite scaffolds for potential application for CLP repair. Collagen (C), bioglass (BG), and LyPRF were used to fabricate a biocomposite (C-BG-LyPRF) scaffold. The physical, chemical, and biocompatibility properties of the scaffold were evaluated. The C-BG-LyPRF scaffold demonstrated a mean pore diameter of 146 µm within a porosity of 87.26%. The FTIR spectra verified the presence of am-ide I, II, and III functional groups. The inorganic phase of the C-BG-LyPRF scaffold was composed of sodium, calcium, silicon, and phosphorus, as determined by EDX analysis. Furthermore, C-BG-LyPRF scaffold was biocompatible with MC3T3-E1 cells in both the Live/Dead and prolif-eration assays. Data demonstrate the developed C-BG-LyPRF scaffold exhibits biomimetic and biocompatibility properties, establishing it as a promising biomaterial for craniofacial regeneration.</p>","PeriodicalId":14985,"journal":{"name":"Journal of Applied Biomaterials & Functional Materials","volume":"22 ","pages":"22808000241289208"},"PeriodicalIF":3.1,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142377937","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Fracture resistance evaluation of CAD/CAM zirconia and composite primary molar crowns with different occlusal thicknesses. 不同咬合厚度的 CAD/CAM 氧化锆和复合材料基磨牙冠的抗断裂性评估。
IF 2.5 4区 医学 Q2 BIOPHYSICS Pub Date : 2024-01-01 DOI: 10.1177/22808000241235994
Arif Bolaca, Yıldırım Erdoğan

Objective: To evaluate the effect of different CAD/CAM materials and occlusal thicknesses on the fracture resistance of primary molar crowns.

Methods: Sixty extracted primary molar teeth were prepared and randomly divided into six experimental groups according to the material and thickness. Primary molar crowns with a central groove thickness of 0.3 and 0.5 mm were fabricated from CAD/CAM zirconia (group Z), zirconia-reinforced lithium silicate (group ZLS), and pre-polymerized composite resin blocks (group C). Each crown was cemented with self-adhesive resin cement on the prepared tooth. All specimens were subjected to fracture tests until fracture. Fracture load values were recorded in Newtons (N). Data were statistically analyzed using a two-way analysis of variance (ANOVA) followed by Tukey multiple comparison test.

Results: The highest fracture load values were obtained in group Z at 0.5 mm occlusal thickness and were significantly higher compared with the other experimental groups (p < 0.05). Although the lowest fracture load values were obtained in group ZLS at 0.3 mm occlusal thickness, all the tested CAD/CAM primary molar crowns at both thicknesses demonstrated fracture load values exceeding reported chewing force in pediatric patients.

Conclusion: CAD/CAM primary molar crowns with reduced occlusal thickness may be used for the full-coverage restoration of primary molar teeth.

目的:评估不同的 CAD/CAM 材料和咬合厚度对基牙牙冠抗折性的影响:评估不同的 CAD/CAM 材料和咬合厚度对基牙牙冠抗折性的影响:制备 60 颗拔出的基磨牙,并根据材料和厚度随机分为 6 个实验组。用 CAD/CAM 氧化锆(Z 组)、氧化锆增强硅酸锂(ZLS 组)和预聚合复合树脂块(C 组)制作中心槽厚度为 0.3 毫米和 0.5 毫米的基磨牙牙冠。每个牙冠都用自粘性树脂粘接剂粘接在制备好的牙齿上。所有试样均进行断裂测试,直至断裂。断裂荷载值以牛顿(N)为单位记录。使用双向方差分析(ANOVA)对数据进行统计分析,然后进行 Tukey 多重比较试验:结果:Z 组在咬合厚度为 0.5 毫米时获得的断裂载荷值最高,与其他实验组相比明显较高(p 结论:Z 组的断裂载荷值最高,与其他实验组相比明显较高(p):减少咬合厚度的 CAD/CAM 基磨牙冠可用于基磨牙的全覆盖修复。
{"title":"Fracture resistance evaluation of CAD/CAM zirconia and composite primary molar crowns with different occlusal thicknesses.","authors":"Arif Bolaca, Yıldırım Erdoğan","doi":"10.1177/22808000241235994","DOIUrl":"10.1177/22808000241235994","url":null,"abstract":"<p><strong>Objective: </strong>To evaluate the effect of different CAD/CAM materials and occlusal thicknesses on the fracture resistance of primary molar crowns.</p><p><strong>Methods: </strong>Sixty extracted primary molar teeth were prepared and randomly divided into six experimental groups according to the material and thickness. Primary molar crowns with a central groove thickness of 0.3 and 0.5 mm were fabricated from CAD/CAM zirconia (group Z), zirconia-reinforced lithium silicate (group ZLS), and pre-polymerized composite resin blocks (group C). Each crown was cemented with self-adhesive resin cement on the prepared tooth. All specimens were subjected to fracture tests until fracture. Fracture load values were recorded in Newtons (N). Data were statistically analyzed using a two-way analysis of variance (ANOVA) followed by Tukey multiple comparison test.</p><p><strong>Results: </strong>The highest fracture load values were obtained in group Z at 0.5 mm occlusal thickness and were significantly higher compared with the other experimental groups (<i>p</i> < 0.05). Although the lowest fracture load values were obtained in group ZLS at 0.3 mm occlusal thickness, all the tested CAD/CAM primary molar crowns at both thicknesses demonstrated fracture load values exceeding reported chewing force in pediatric patients.</p><p><strong>Conclusion: </strong>CAD/CAM primary molar crowns with reduced occlusal thickness may be used for the full-coverage restoration of primary molar teeth.</p>","PeriodicalId":14985,"journal":{"name":"Journal of Applied Biomaterials & Functional Materials","volume":"22 ","pages":"22808000241235994"},"PeriodicalIF":2.5,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139990162","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Evaluation of microstructure evolution and mechanical properties of Al-10Zn-1.63Si/Irvingia gabonensis particulates alloy composites. 评估 Al-10Zn-1.63Si/Irvingia gabonensis 粒子合金复合材料的微观结构演变和机械性能。
IF 2.5 4区 医学 Q2 BIOPHYSICS Pub Date : 2024-01-01 DOI: 10.1177/22808000241236021
Chukwuneke Jeremiah Lekwuwa, Sinebe Jude Ebieladoh, Umahi Justice Chidi, Nnakwo Kingsley Chidi, Olisakwe Henry Chukwuemeka

This study demonstrates the feasibility of using Irvingia gabonensis shell particulates (IGSp) as alternative reinforcing materials in the development of aluminium-based composites. In this experimental study, the microstructure, phase composition, and mechanical behaviour of Al-10Zn-1.63Si/xIGSp (wt%, x = 1, 3, 5 and 7) composites were investigated. The Al-10Zn-1.63Si based composites were fabricated using the stir-casting technique. Different weight percentages (1, 3, 5 and 7) of IGSp were added to the Al-10Zn-1.63Si matrix. The chemical constituents of the IGSp were determined using X-ray fluorescence (XRF). The grain characteristics and phase(s) compositions were determined using Scanning Electron Microscopy (SEM) and X-ray diffractometer (XRD). The ultimate tensile strength, hardness, and impact strength of the developed composites were also determined. The SEM and XRD results revealed the presence of different phases: aluminium phosphate (Al16P16O64), gahnite (ZnAl2O4), andalusite (Al2SiO5), Quartz (SiO2) and aluminium silicate (Al2O3.5.SiO2). Results show that addition of IGSp led to an increase in ultimate tensile strength, with the highest value (128 MPa) obtained at 3 wt% IGSp. The hardness of the composites increased with increasing concentrations of IGSp, reaching a maximum value of 285 HV after adding 7 wt% IGSp. The impact strength improved with the addition of IGSp, with the highest value (30 J) obtained at 1 wt% IGSp. The improvements in mechanical properties were attributed to the dispersion of three major phases: aluminium silicate (Al2O3.54.SiO2), Al16P16O64 and Al2O3.54.SiO2. These phases contributed to the enhanced strength and hardness of the composites. The study noted a sudden decrease in ultimate tensile strength with higher concentrations of IGSp due to the increase in the intensities of Al16P16O64 and precipitation of hard but brittle new phase; Al2Si60.6O126.33. The study concludes that IGSp has the potential to serve as an alternative reinforcing material for aluminium-based composites.

本研究证明了在铝基复合材料的开发中使用加蓬伊文尼亚壳颗粒(IGSp)作为替代增强材料的可行性。在这项实验研究中,研究了 Al-10Zn-1.63Si/xIGSp(重量百分比,x = 1、3、5 和 7)复合材料的微观结构、相组成和机械性能。铝-10Zn-1.63Si 复合材料是用搅拌铸造技术制造的。在 Al-10Zn-1.63Si 基体中添加了不同重量百分比(1、3、5 和 7)的 IGSp。使用 X 射线荧光 (XRF) 测定了 IGSp 的化学成分。使用扫描电子显微镜(SEM)和 X 射线衍射仪(XRD)测定了晶粒特征和相组成。此外,还测定了所开发复合材料的极限拉伸强度、硬度和冲击强度。扫描电子显微镜和 X 射线衍射仪的结果表明存在不同的物相:磷酸铝(Al16P16O64)、芒硝(ZnAl2O4)、黄铁矿(Al2SiO5)、石英(SiO2)和硅酸铝(Al2O3.5.SiO2)。结果表明,添加 IGSp 可提高极限拉伸强度,在添加 3 wt% IGSp 时可获得最高值(128 兆帕)。复合材料的硬度随着 IGSp 浓度的增加而增加,在添加 7 wt% IGSp 后达到最大值 285 HV。冲击强度随着 IGSp 的添加而提高,在添加 1 wt% IGSp 时达到最高值(30 J)。机械性能的改善归因于三种主要相的分散:硅酸铝(Al2O3.54.SiO2)、Al16P16O64 和 Al2O3.54.SiO2。这些相有助于增强复合材料的强度和硬度。研究注意到,随着 IGSp 浓度的增加,极限拉伸强度会突然下降,这是由于 Al16P16O64 的强度增加以及析出了硬而脆的新相:Al2Si60.6O126.33。研究得出结论,IGSp 有潜力成为铝基复合材料的替代增强材料。
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Journal of Applied Biomaterials & Functional Materials
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