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Effects of composition and pH on the degradation of hyaluronate and carboxymethyl cellulose gels and release of nanocrystalline silver. 成分和 pH 值对透明质酸和羧甲基纤维素凝胶降解及纳米银释放的影响
IF 2.5 4区 医学 Q2 Biochemistry, Genetics and Molecular Biology Pub Date : 2024-01-01 DOI: 10.1177/22808000241257124
Colleen Nancy Ward, Payton E LeBlanc, Robert Edward Burrell

Adhesions are fibrous tissue connections which are a common complication of surgical procedures and may be prevented by protecting tissue surfaces and reducing inflammation. The combination of biodegradable polymers and nanocrystalline silver can be used to create an anti-inflammatory gel to be applied during surgery. In this study, sodium hyaluronate and sodium carboxymethyl cellulose were added in concentrations from 0.25% to 1% w/v to aqueous nanocrystalline silver solutions to create viscous gels. Gels were loaded into dialysis cassettes and placed in PBS for 3 days. pH was adjusted using potassium phosphate monobasic and sodium hydroxide. Release of silver into the PBS was measured at several time points. Polymer degradation was compared by measuring the viscosity of the gels before and after the experiment. Gels lost up to 84% of initial viscosity over 3 days and released between 24% and 41% of the added silver. Gels with higher initial viscosity did not have a greater degree of degradation, as measured by percent viscosity reduction, but still resulted in a higher final viscosity. Silver release was not significantly impacted by pH or composition, but still varied between experimental groups.

粘连是一种纤维组织连接,是外科手术的常见并发症,可通过保护组织表面和减少炎症来预防。可生物降解聚合物和纳米银的组合可用于制作消炎凝胶,在手术过程中使用。在这项研究中,透明质酸钠和羧甲基纤维素钠以 0.25% 至 1% w/v 的浓度添加到纳米银水溶液中,形成粘性凝胶。将凝胶装入透析盒,在 PBS 中放置 3 天,用磷酸二氢钾和氢氧化钠调节 pH 值。在几个时间点测量银在 PBS 中的释放量。通过测量实验前后凝胶的粘度来比较聚合物降解情况。凝胶在 3 天内降解了 84% 的初始粘度,并释放了 24% 至 41% 的添加银。初始粘度较高的凝胶降解程度并不高,以粘度降低的百分比来衡量,但最终粘度仍然较高。银的释放不受 pH 值或成分的明显影响,但各实验组之间仍有差异。
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引用次数: 0
Retraction Comparison of adhesive bond strength among fiber reinforced post and core with different cementation techniques: In vitro study. 回缩 采用不同粘接技术的纤维增强骨柱和骨核的粘接强度比较:体外研究
IF 3.1 4区 医学 Q2 BIOPHYSICS Pub Date : 2024-01-01 DOI: 10.1177/22808000241273951
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引用次数: 0
Application of Aleppo pine extract for skin burn treatment. 应用阿勒颇松提取物治疗皮肤烧伤。
IF 2.5 4区 医学 Q2 Biochemistry, Genetics and Molecular Biology Pub Date : 2024-01-01 DOI: 10.1177/22808000241236020
Najoua Salhi, Otman El Guourrami, Abdelaali Balahbib, Lamiae Rouas, Siham Moussaid, Amina Moutawalli, Fatima Zahra Benkhouili, Mouna Ameggouz, Riaz Ullah, Amal Alotaibi, Abdelhakim Bouyahya, Ching Siang Tan, Long Chiau Ming, My El Abbes Faouzi, Yahya Cherrah

Objective: To investigate the Pinus halepensis extracts and determine its healing and antibacterial effects, and to evaluate the treatment of skin burns.

Methods: Aqueous and ethanolic extracts and topical based on Aleppo pine plant extracts were prepared. Thirty male and female Wistar rats were used to study the cutaneous toxicity of extracts from the bark of P. halepensis. The extracts' healing potential for burn wounds were also assessed by evaluating the clinical and macroscopic aspects of the wounds. The antibacterial activity of crude extracts of P. halepensis as well as its wound healing abilities was verified in this investigation.

Results: In animals with acute dermal toxicity, there were no signs of treatment-related toxicity or death. The extracts of these plants could be transformed into phytomedicines for the treatment of infected wounds. The results demonstrated that formulated ointments are successful in treating second-degree burns in rats and may be suitable for the short-term therapeutic treatment of second-degree burns.

Conclusion: This study successfully answered our problem, regarding the efficacy of our extract for treating second-degree burns in rats. Further studies are needed to confirm these results by identifying the molecules responsible for these activities and examining their mechanism of action.

目的研究欧洲赤松(Pinus halepensis)提取物,确定其愈合和抗菌效果,并评估其对皮肤烧伤的治疗效果:方法:制备水提取物、乙醇提取物和基于阿勒颇松植物提取物的外用药。用 30 只雄性和雌性 Wistar 大鼠研究阿勒颇松树皮提取物的皮肤毒性。此外,还通过评估伤口的临床和宏观方面,评估了提取物对烧伤伤口的愈合潜力。在这项研究中,验证了半枝莲粗萃取物的抗菌活性及其伤口愈合能力:结果:在急性皮肤中毒的动物中,没有出现与治疗相关的中毒或死亡迹象。这些植物的提取物可转化为治疗感染伤口的植物药。结果表明,配制的软膏能成功治疗大鼠的二度烧伤,可能适合二度烧伤的短期治疗:这项研究成功地回答了我们的问题,即我们的提取物对治疗大鼠二度烧伤的疗效。为了证实这些结果,还需要进行进一步的研究,确定这些活性的分子并研究其作用机制。
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引用次数: 0
Exploring the purity of chitin from crustacean sources using deep eutectic solvents: A machine learning approach. 利用深共晶溶剂探索甲壳素的纯度:机器学习方法。
IF 2.5 4区 医学 Q2 Biochemistry, Genetics and Molecular Biology Pub Date : 2024-01-01 DOI: 10.1177/22808000241248887
Sasireka Rajendran, Madheswaran Muthusamy

Objective: Chitin a natural polymer is abundant in several sources such as shells of crustaceans, mollusks, insects, and fungi. Several possible attempts have been made to recover chitin because of its importance in biomedical applications in various forms such as hydrogel, nanoparticles, nanosheets, nanowires, etc. Among them, deep eutectic solvents have gained much consideration because of their eco-friendly and recyclable nature. However, several factors need to be addressed to obtain a pure form of chitin with a high yield. The development of an innovative system for the production of quality chitin is of prime importance and is still challenging.

Methods: The present study intended to develop a novel and robust approach to investigate chitin purity from various crustacean shell wastes using deep eutectic solvents. This investigation will assist in envisaging the important influencing parameters to obtain a pure form of chitin via a machine learning approach. Different machine learning algorithms have been proposed to model chitin purity by considering the enormous experimental dataset retrieved from previously conducted experiments. Several input variables have been selected to assess chitin purity as the output variable.

Results: The statistical criteria of the proposed model have been critically investigated and it was observed that the results indicate XGBoost has the maximum predictive accuracy of 0.95 compared with other selected models. The RMSE and MAE values were also minimal in the XGBoost model. In addition, it revealed better input variables to obtain pure chitin with minimal processing time.

Conclusion: This study validates that machine learning paves the way for complex problems with substantial datasets and can be an inexpensive and time-saving model for analyzing chitin purity from crustacean shells.

目的甲壳素是一种天然聚合物,在甲壳类动物、软体动物、昆虫和真菌的外壳等多种来源中含量丰富。由于甲壳素在生物医学应用中的重要性,人们已尝试以各种形式(如水凝胶、纳米颗粒、纳米片、纳米线等)回收甲壳素。其中,深共晶溶剂因其环保和可回收的特性而备受关注。然而,要获得高产率的纯甲壳素需要解决几个因素。开发一种生产优质甲壳素的创新系统至关重要,但目前仍面临挑战:本研究旨在开发一种新颖、稳健的方法,利用深共晶溶剂从各种甲壳类贝壳废料中研究甲壳素的纯度。这项研究将有助于通过机器学习方法设想获得纯甲壳素的重要影响参数。考虑到从以前进行的实验中获取的大量实验数据集,我们提出了不同的机器学习算法,以建立甲壳素纯度模型。我们选择了几个输入变量来评估作为输出变量的甲壳素纯度:对所提模型的统计标准进行了严格研究,结果表明,与其他选定模型相比,XGBoost 的预测准确率最高,达到 0.95。XGBoost 模型的 RMSE 和 MAE 值也最小。此外,它还揭示了更好的输入变量,从而以最短的加工时间获得纯甲壳素:这项研究证明,机器学习为解决复杂问题和大量数据集铺平了道路,并且可以成为分析甲壳类动物甲壳素纯度的一种廉价省时的模型。
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引用次数: 0
In vitro assessment of Momordica charantia/Hypericum perforatum oils loaded PCL/Collagen fibers: Novel scaffold for tissue engineering. 对负载 PCL/胶原纤维的 Momordica charantia/Hypericum perforatum 油进行体外评估:用于组织工程的新型支架
IF 2.5 4区 医学 Q2 Biochemistry, Genetics and Molecular Biology Pub Date : 2024-01-01 DOI: 10.1177/22808000231221067
Emre Fatih Ediz, Cansu Güneş, Meltem Demirel Kars, Ahmet Avcı

The research on tissue engineering applications has been progressing to manufacture ideal tissue scaffold biomaterials. In this study, a double-layered electrospun biofiber scaffold biomaterial including Polycaprolactone (PCL)/Collagen (COL) fibrous inner layer and PCL/ Momordica charantia (MC) and Hypericum perforatum (HP) oils fibrous outer layer was developed to manufacture a functional, novel tissue scaffold with the advantageous mechanical and biological properties. The main approach was to combine the natural perspective using medicinal oils with an engineering point of view to fabricate a potential functional scaffold for tissue engineering. Medicinal plants MC and HP are rich in functional oils and incorporation of them in a tissue scaffold will unveil their potential to augment both new tissue formation and wound healing. In this study, a novel double-layered scaffold prototype was fabricated using electrospinning technique with two PCL fiber layers, first is composed of collagen, and second is composed of oils extracted from medicinal plants. Initially, the composition of plant oils was analyzed. Thereafter the biofiber scaffold layers were fabricated and were evaluated in terms of morphology, physicochemistry, thermal and mechanical features, wettability, in vitro bio-degradability. Double-layered scaffold prototype was further analyzed in terms of in vitro biocompatibility and antibacterial effect. The medicinal oils blend provided antioxidant and antibacterial properties to the novel PCL/Oils layer. The results signify that inner PCL/COL layer exhibited advanced biodegradability of 8.5% compared to PCL and enhanced wettability with 11.7° contact angle. Strength of scaffold prototype was 5.98 N/mm2 thanks to the elastic PCL fibrous matrix. The double-layered functional biofiber scaffold enabled 92% viability after 72 h contact with fibroblast cells and furthermore provided feasible attachment sites for the cells. The functional scaffold prototype's noteworthy mechanical, chemical, and biological features enable it to be suggested as a different novel biomaterial with the potential to be utilized in tissue engineering applications.

为制造理想的组织支架生物材料,有关组织工程应用的研究一直在取得进展。本研究开发了一种双层电纺生物纤维支架生物材料,包括聚己内酯(PCL)/胶原蛋白(COL)纤维内层和 PCL/ Momordica charantia(MC)和金丝桃油(HP)纤维外层,以制造一种具有良好机械和生物特性的功能性新型组织支架。主要方法是将药用油脂的自然观点与工程观点相结合,为组织工程制造一种潜在的功能性支架。药用植物 MC 和 HP 含有丰富的功能性油脂,将它们融入组织支架中将会发现它们在促进新组织形成和伤口愈合方面的潜力。本研究利用电纺丝技术制造了一种新型双层支架原型,其中有两层 PCL 纤维,第一层由胶原蛋白组成,第二层由从药用植物中提取的油组成。首先分析了植物油的成分。之后,制作了生物纤维支架层,并从形态、物理化学、热和机械特性、润湿性、体外生物降解性等方面进行了评估。还进一步分析了双层支架原型的体外生物相容性和抗菌效果。药用油混合物为新型 PCL/油层提供了抗氧化和抗菌特性。结果表明,与 PCL 相比,PCL/COL 内层的生物降解性提高了 8.5%,润湿性增强,接触角为 11.7°。由于 PCL 纤维基质具有弹性,支架原型的强度为 5.98 N/mm2。在与成纤维细胞接触 72 小时后,双层功能生物纤维支架的存活率达到 92%,而且还为细胞提供了可行的附着点。该功能性支架原型具有显著的机械、化学和生物特性,因此被认为是一种新型生物材料,有望应用于组织工程领域。
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引用次数: 0
Retraction Notice: "Anti-fungal efficacy of Miswak Extract (Salvadora Persica) and commercial cleaner against Candida albicans on heat cured polymethylmethacrylate denture base". 撤稿通知:"Miswak Extract(Salvadora Persica)和商用清洁剂对热固化聚甲基丙烯酸甲酯义齿基托上白色念珠菌的抗真菌功效"。
IF 2.5 4区 医学 Q2 Biochemistry, Genetics and Molecular Biology Pub Date : 2024-01-01 DOI: 10.1177/22808000241227498
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引用次数: 0
Retraction Notice: "Role of mineral trioxide aggregate in dentistry: A bibliometric analysis using Scopus database". 撤稿通知:"三氧化物矿物质聚合体在牙科中的作用:使用 Scopus 数据库进行文献计量分析"。
IF 2.5 4区 医学 Q2 Biochemistry, Genetics and Molecular Biology Pub Date : 2024-01-01 DOI: 10.1177/22808000231222708
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引用次数: 0
Evaluation of microstructure evolution and mechanical properties of Al-10Zn-1.63Si/Irvingia gabonensis particulates alloy composites. 评估 Al-10Zn-1.63Si/Irvingia gabonensis 粒子合金复合材料的微观结构演变和机械性能。
IF 2.5 4区 医学 Q2 Biochemistry, Genetics and Molecular Biology Pub Date : 2024-01-01 DOI: 10.1177/22808000241236021
Chukwuneke Jeremiah Lekwuwa, Sinebe Jude Ebieladoh, Umahi Justice Chidi, Nnakwo Kingsley Chidi, Olisakwe Henry Chukwuemeka

This study demonstrates the feasibility of using Irvingia gabonensis shell particulates (IGSp) as alternative reinforcing materials in the development of aluminium-based composites. In this experimental study, the microstructure, phase composition, and mechanical behaviour of Al-10Zn-1.63Si/xIGSp (wt%, x = 1, 3, 5 and 7) composites were investigated. The Al-10Zn-1.63Si based composites were fabricated using the stir-casting technique. Different weight percentages (1, 3, 5 and 7) of IGSp were added to the Al-10Zn-1.63Si matrix. The chemical constituents of the IGSp were determined using X-ray fluorescence (XRF). The grain characteristics and phase(s) compositions were determined using Scanning Electron Microscopy (SEM) and X-ray diffractometer (XRD). The ultimate tensile strength, hardness, and impact strength of the developed composites were also determined. The SEM and XRD results revealed the presence of different phases: aluminium phosphate (Al16P16O64), gahnite (ZnAl2O4), andalusite (Al2SiO5), Quartz (SiO2) and aluminium silicate (Al2O3.5.SiO2). Results show that addition of IGSp led to an increase in ultimate tensile strength, with the highest value (128 MPa) obtained at 3 wt% IGSp. The hardness of the composites increased with increasing concentrations of IGSp, reaching a maximum value of 285 HV after adding 7 wt% IGSp. The impact strength improved with the addition of IGSp, with the highest value (30 J) obtained at 1 wt% IGSp. The improvements in mechanical properties were attributed to the dispersion of three major phases: aluminium silicate (Al2O3.54.SiO2), Al16P16O64 and Al2O3.54.SiO2. These phases contributed to the enhanced strength and hardness of the composites. The study noted a sudden decrease in ultimate tensile strength with higher concentrations of IGSp due to the increase in the intensities of Al16P16O64 and precipitation of hard but brittle new phase; Al2Si60.6O126.33. The study concludes that IGSp has the potential to serve as an alternative reinforcing material for aluminium-based composites.

本研究证明了在铝基复合材料的开发中使用加蓬伊文尼亚壳颗粒(IGSp)作为替代增强材料的可行性。在这项实验研究中,研究了 Al-10Zn-1.63Si/xIGSp(重量百分比,x = 1、3、5 和 7)复合材料的微观结构、相组成和机械性能。铝-10Zn-1.63Si 复合材料是用搅拌铸造技术制造的。在 Al-10Zn-1.63Si 基体中添加了不同重量百分比(1、3、5 和 7)的 IGSp。使用 X 射线荧光 (XRF) 测定了 IGSp 的化学成分。使用扫描电子显微镜(SEM)和 X 射线衍射仪(XRD)测定了晶粒特征和相组成。此外,还测定了所开发复合材料的极限拉伸强度、硬度和冲击强度。扫描电子显微镜和 X 射线衍射仪的结果表明存在不同的物相:磷酸铝(Al16P16O64)、芒硝(ZnAl2O4)、黄铁矿(Al2SiO5)、石英(SiO2)和硅酸铝(Al2O3.5.SiO2)。结果表明,添加 IGSp 可提高极限拉伸强度,在添加 3 wt% IGSp 时可获得最高值(128 兆帕)。复合材料的硬度随着 IGSp 浓度的增加而增加,在添加 7 wt% IGSp 后达到最大值 285 HV。冲击强度随着 IGSp 的添加而提高,在添加 1 wt% IGSp 时达到最高值(30 J)。机械性能的改善归因于三种主要相的分散:硅酸铝(Al2O3.54.SiO2)、Al16P16O64 和 Al2O3.54.SiO2。这些相有助于增强复合材料的强度和硬度。研究注意到,随着 IGSp 浓度的增加,极限拉伸强度会突然下降,这是由于 Al16P16O64 的强度增加以及析出了硬而脆的新相:Al2Si60.6O126.33。研究得出结论,IGSp 有潜力成为铝基复合材料的替代增强材料。
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引用次数: 0
Fracture resistance evaluation of CAD/CAM zirconia and composite primary molar crowns with different occlusal thicknesses. 不同咬合厚度的 CAD/CAM 氧化锆和复合材料基磨牙冠的抗断裂性评估。
IF 2.5 4区 医学 Q2 Biochemistry, Genetics and Molecular Biology Pub Date : 2024-01-01 DOI: 10.1177/22808000241235994
Arif Bolaca, Yıldırım Erdoğan

Objective: To evaluate the effect of different CAD/CAM materials and occlusal thicknesses on the fracture resistance of primary molar crowns.

Methods: Sixty extracted primary molar teeth were prepared and randomly divided into six experimental groups according to the material and thickness. Primary molar crowns with a central groove thickness of 0.3 and 0.5 mm were fabricated from CAD/CAM zirconia (group Z), zirconia-reinforced lithium silicate (group ZLS), and pre-polymerized composite resin blocks (group C). Each crown was cemented with self-adhesive resin cement on the prepared tooth. All specimens were subjected to fracture tests until fracture. Fracture load values were recorded in Newtons (N). Data were statistically analyzed using a two-way analysis of variance (ANOVA) followed by Tukey multiple comparison test.

Results: The highest fracture load values were obtained in group Z at 0.5 mm occlusal thickness and were significantly higher compared with the other experimental groups (p < 0.05). Although the lowest fracture load values were obtained in group ZLS at 0.3 mm occlusal thickness, all the tested CAD/CAM primary molar crowns at both thicknesses demonstrated fracture load values exceeding reported chewing force in pediatric patients.

Conclusion: CAD/CAM primary molar crowns with reduced occlusal thickness may be used for the full-coverage restoration of primary molar teeth.

目的:评估不同的 CAD/CAM 材料和咬合厚度对基牙牙冠抗折性的影响:评估不同的 CAD/CAM 材料和咬合厚度对基牙牙冠抗折性的影响:制备 60 颗拔出的基磨牙,并根据材料和厚度随机分为 6 个实验组。用 CAD/CAM 氧化锆(Z 组)、氧化锆增强硅酸锂(ZLS 组)和预聚合复合树脂块(C 组)制作中心槽厚度为 0.3 毫米和 0.5 毫米的基磨牙牙冠。每个牙冠都用自粘性树脂粘接剂粘接在制备好的牙齿上。所有试样均进行断裂测试,直至断裂。断裂荷载值以牛顿(N)为单位记录。使用双向方差分析(ANOVA)对数据进行统计分析,然后进行 Tukey 多重比较试验:结果:Z 组在咬合厚度为 0.5 毫米时获得的断裂载荷值最高,与其他实验组相比明显较高(p 结论:Z 组的断裂载荷值最高,与其他实验组相比明显较高(p):减少咬合厚度的 CAD/CAM 基磨牙冠可用于基磨牙的全覆盖修复。
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引用次数: 0
Full-ceramic resin-bonded fixed dental prostheses: A systematic review. 全陶瓷树脂粘结固定义齿:系统综述。
IF 2.5 4区 医学 Q2 Biochemistry, Genetics and Molecular Biology Pub Date : 2024-01-01 DOI: 10.1177/22808000241250118
Sareh Habibzadeh, Faranak Khamisi, Seyed Ali Mosaddad, Gustavo Vicentis de Oliveira Fernandes, Artak Heboyan

Despite the development of implant-supported prostheses, there are still patients for whom conservative treatments such as resin-bonded fixed dental prostheses (RBFDPs) are more appropriate. This study's objective was to analyze the available research on full-ceramic RBFDPs. In this study, Web of Science, MEDLINE/PubMed, Scopus, Embase, Cochrane Library, and Google Scholar databases were searched for articles published in English between 2010 and 2020. A total of 14 studies were reviewed based on the eligibility criteria. The results showed that using a cantilever design with one abutment had an advantage over two abutments. Additionally, it was proposed that preparations designed with retentive aids, such as a proximal box, groove, and pinhole, could improve RBFDP survival rates. IPS e.max ZirCAD, In-Ceram alumina, and zirconia CAD/CAM were the most commonly used framework materials. Most studies used air abrasion, salinization, or hydrofluoric acid for surface treatment. Adhesive resin cements were the most frequently used type of cement. The survival rate of In-Ceram ceramics (85.3%-94.8%) was lower than that of In-Ceram zirconia and IPS e.max ZirCAD. Debonding, followed by framework fracture, was the leading cause of failure. Following 3-10 years follow-up, the survival percentage of all-ceramic RBFDPs ranged from 76% to 100%. Although RBFDPs have demonstrated satisfactory success as a conservative treatment, long-term follow-ups and higher sample sizes in clinical research are required to gain more reliable outcomes on the clinical success rate of various RBFDP designs.

尽管种植体支持义齿已经发展成熟,但仍有一些患者更适合采用树脂粘结固定义齿(RBFDP)等保守治疗方法。本研究的目的是分析关于全瓷 RBFDP 的现有研究。在这项研究中,我们检索了 Web of Science、MEDLINE/PubMed、Scopus、Embase、Cochrane Library 和 Google Scholar 数据库中 2010 年至 2020 年间发表的英文文章。根据资格标准,共审查了 14 项研究。结果显示,使用一个基台的悬臂设计比使用两个基台更有优势。此外,研究还提出,带有固位辅助装置(如近端盒、凹槽和针孔)的基台可以提高 RBFDP 的存活率。IPS e.max ZirCAD、In-Ceram 氧化铝和氧化锆 CAD/CAM 是最常用的框架材料。大多数研究使用气磨、盐渍化或氢氟酸进行表面处理。粘接性树脂水门汀是最常用的水门汀类型。In-Ceram陶瓷的存活率(85.3%-94.8%)低于In-Ceram氧化锆和IPS e.max ZirCAD。脱粘是失败的主要原因,其次是骨架断裂。经过 3-10 年的随访,全陶瓷 RBFDP 的存活率从 76% 到 100% 不等。虽然 RBFDP 作为一种保守治疗方法已经取得了令人满意的效果,但要想获得各种 RBFDP 设计临床成功率的更可靠结果,还需要在临床研究中进行长期随访和增加样本量。
{"title":"Full-ceramic resin-bonded fixed dental prostheses: A systematic review.","authors":"Sareh Habibzadeh, Faranak Khamisi, Seyed Ali Mosaddad, Gustavo Vicentis de Oliveira Fernandes, Artak Heboyan","doi":"10.1177/22808000241250118","DOIUrl":"10.1177/22808000241250118","url":null,"abstract":"<p><p>Despite the development of implant-supported prostheses, there are still patients for whom conservative treatments such as resin-bonded fixed dental prostheses (RBFDPs) are more appropriate. This study's objective was to analyze the available research on full-ceramic RBFDPs. In this study, Web of Science, MEDLINE/PubMed, Scopus, Embase, Cochrane Library, and Google Scholar databases were searched for articles published in English between 2010 and 2020. A total of 14 studies were reviewed based on the eligibility criteria. The results showed that using a cantilever design with one abutment had an advantage over two abutments. Additionally, it was proposed that preparations designed with retentive aids, such as a proximal box, groove, and pinhole, could improve RBFDP survival rates. IPS e.max ZirCAD, In-Ceram alumina, and zirconia CAD/CAM were the most commonly used framework materials. Most studies used air abrasion, salinization, or hydrofluoric acid for surface treatment. Adhesive resin cements were the most frequently used type of cement. The survival rate of In-Ceram ceramics (85.3%-94.8%) was lower than that of In-Ceram zirconia and IPS e.max ZirCAD. Debonding, followed by framework fracture, was the leading cause of failure. Following 3-10 years follow-up, the survival percentage of all-ceramic RBFDPs ranged from 76% to 100%. Although RBFDPs have demonstrated satisfactory success as a conservative treatment, long-term follow-ups and higher sample sizes in clinical research are required to gain more reliable outcomes on the clinical success rate of various RBFDP designs.</p>","PeriodicalId":14985,"journal":{"name":"Journal of Applied Biomaterials & Functional Materials","volume":null,"pages":null},"PeriodicalIF":2.5,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140865277","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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