Pub Date : 2018-04-10DOI: 10.18869/ACADPUB.JBUMS.20.9.36
حسن مروتی, محمدعلی بابایی, زهرا طوطیان, سیمین فاضلی پور, حجت عنبرا, عظیم اکبرزاده
{"title":"اثرات ویتامین E بر آسیبهای کبدی و کلیوی ناشی از مصرف دیانابول در موشهای سفید کوچک آزمایشگاهی","authors":"حسن مروتی, محمدعلی بابایی, زهرا طوطیان, سیمین فاضلی پور, حجت عنبرا, عظیم اکبرزاده","doi":"10.18869/ACADPUB.JBUMS.20.9.36","DOIUrl":"https://doi.org/10.18869/ACADPUB.JBUMS.20.9.36","url":null,"abstract":"","PeriodicalId":15108,"journal":{"name":"Journal of Babol University of Medical Sciences","volume":"1 1","pages":"36-47"},"PeriodicalIF":0.0,"publicationDate":"2018-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88633317","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2018-04-10DOI: 10.18869/ACADPUB.JBUMS.20.4.24
R. A. Aghali, M. Khalaj, N. Zeinalzadeh, H. Feizi, M. Farhoudi, M. Talebi
J Babol Univ Med Sci; 20(4); Apr 2018; PP: 24-9 Received: Oct 3
巴宝勒大学医学杂志;20 (4);4月2018;收稿时间:10月3日
{"title":"Comparison between the Plasma Levels of Long Noncoding RNA BDNF-AS in Patients with Alzheimer's disease and Healthy Subjects","authors":"R. A. Aghali, M. Khalaj, N. Zeinalzadeh, H. Feizi, M. Farhoudi, M. Talebi","doi":"10.18869/ACADPUB.JBUMS.20.4.24","DOIUrl":"https://doi.org/10.18869/ACADPUB.JBUMS.20.4.24","url":null,"abstract":"J Babol Univ Med Sci; 20(4); Apr 2018; PP: 24-9 Received: Oct 3","PeriodicalId":15108,"journal":{"name":"Journal of Babol University of Medical Sciences","volume":"89 1","pages":"24-29"},"PeriodicalIF":0.0,"publicationDate":"2018-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84390391","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2018-04-10DOI: 10.18869/ACADPUB.JBUMS.20.4.48
H. Kamali, Khazaei, E. Shobeiri, M. Khazaei
BACKGROUND AND OBJECTIVE: Thrombocytopenia is one of the complications of chemotherapy drugs that may cause death. Different animal models of thrombocytopenia are used for clinical research and identification of its causes, each with advantages and disadvantages. The aim of this review article is to investigate the methods of thrombocytopenia induction in laboratory animals and their advantages and disadvantages. METHODS: This systematic review was conducted using the keywords “thrombocytopenia platelet”, “chemotherapy”, “animal model”, in PubMed, Science Direct and Scopus databases from 1990 until October 2017. The title and abstract of several articles were reviewed, and after excluding the unrelated items, final articles were selected and reviewed. FINDINGS: Animal models of thrombocytopenia are of two types of immune and non-immune. Non-immune models reduce platelet production through bone marrow suppression. Antiplatelet antibodies are used in immune models. The immune and non-immune thrombocytopenic models have some advantages and limitations and are selected according to the current therapeutic goals. Mice and rats are commonly used as laboratory animals, and cyclophosphamide and carboplatin are the most commonly used drugs. CONCLUSION: According to the results of this study, due to the limitations of human subject research in diseases that lead to thrombocytopenia, there is a need to develop appropriate animal models for studying and identifying the factors affecting thrombocytopenia.
{"title":"Experimental Models of Thrombocytopenia in Laboratory Animals and their Application in Identifying the Complications of Chemotherapy Drugs","authors":"H. Kamali, Khazaei, E. Shobeiri, M. Khazaei","doi":"10.18869/ACADPUB.JBUMS.20.4.48","DOIUrl":"https://doi.org/10.18869/ACADPUB.JBUMS.20.4.48","url":null,"abstract":"BACKGROUND AND OBJECTIVE: Thrombocytopenia is one of the complications of chemotherapy drugs that may cause death. Different animal models of thrombocytopenia are used for clinical research and identification of its causes, each with advantages and disadvantages. The aim of this review article is to investigate the methods of thrombocytopenia induction in laboratory animals and their advantages and disadvantages. METHODS: This systematic review was conducted using the keywords “thrombocytopenia platelet”, “chemotherapy”, “animal model”, in PubMed, Science Direct and Scopus databases from 1990 until October 2017. The title and abstract of several articles were reviewed, and after excluding the unrelated items, final articles were selected and reviewed. FINDINGS: Animal models of thrombocytopenia are of two types of immune and non-immune. Non-immune models reduce platelet production through bone marrow suppression. Antiplatelet antibodies are used in immune models. The immune and non-immune thrombocytopenic models have some advantages and limitations and are selected according to the current therapeutic goals. Mice and rats are commonly used as laboratory animals, and cyclophosphamide and carboplatin are the most commonly used drugs. CONCLUSION: According to the results of this study, due to the limitations of human subject research in diseases that lead to thrombocytopenia, there is a need to develop appropriate animal models for studying and identifying the factors affecting thrombocytopenia.","PeriodicalId":15108,"journal":{"name":"Journal of Babol University of Medical Sciences","volume":"90 1","pages":"48-58"},"PeriodicalIF":0.0,"publicationDate":"2018-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78408663","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"فراوانی چاقی مرکزی و ارتباط آن با شاخصهای خونی و فشارخون در افراد کاندید آنژیوگرافی الکتیو مراجعه کننده به بیمارستان حشمت شهر رشت در سال 1395","authors":"مرجان مهدوی روشن, ارسلان سالاری, مریم شکیبا, مونا نقشبندی, محبوبه قلی پور","doi":"10.18869/ACADPUB.JBUMS.20.4.35","DOIUrl":"https://doi.org/10.18869/ACADPUB.JBUMS.20.4.35","url":null,"abstract":"","PeriodicalId":15108,"journal":{"name":"Journal of Babol University of Medical Sciences","volume":"30 1","pages":"35-41"},"PeriodicalIF":0.0,"publicationDate":"2018-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82104311","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2018-04-10DOI: 10.18869/ACADPUB.JBUMS.20.4.30
F. Abesi, S. Haghanifar, S. Khafri, Ali Montazeri
1.Dental Materials Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, I.R.Iran. 2.Oral Health Research Center, Institute of Health, Babol University of Medical Sciences, Babol, I.R.Iran. 3.Cancer Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, I.R.Iran. 4.Student Research Committee, Babol University of Medical Sciences, Babol, I.R.Iran.
{"title":"The Evaluation of the Anatomical Variations of Osteomeatal Complex in Cone Beam Computed Tomography Images","authors":"F. Abesi, S. Haghanifar, S. Khafri, Ali Montazeri","doi":"10.18869/ACADPUB.JBUMS.20.4.30","DOIUrl":"https://doi.org/10.18869/ACADPUB.JBUMS.20.4.30","url":null,"abstract":"1.Dental Materials Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, I.R.Iran. 2.Oral Health Research Center, Institute of Health, Babol University of Medical Sciences, Babol, I.R.Iran. 3.Cancer Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, I.R.Iran. 4.Student Research Committee, Babol University of Medical Sciences, Babol, I.R.Iran.","PeriodicalId":15108,"journal":{"name":"Journal of Babol University of Medical Sciences","volume":"44 1","pages":"30-34"},"PeriodicalIF":0.0,"publicationDate":"2018-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88870852","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Compare the Effects of Caffeine on QTc Interval and Blood Pressure During Isometric and Isotonic Contractions in Male Athletes and Non-Athletes","authors":"M. Kashef, N. Nejatmand, Ar Kashef, R. Gheyratmand","doi":"10.18869/ACADPUB.JBUMS.20.3.7","DOIUrl":"https://doi.org/10.18869/ACADPUB.JBUMS.20.3.7","url":null,"abstract":"J Babol Univ Med Sci; 20(3); Mar 2018; PP: 7-14 Received: Jun 2 2017, Revised: Oct 14 2017, Accepted: Dec 1","PeriodicalId":15108,"journal":{"name":"Journal of Babol University of Medical Sciences","volume":"2 1","pages":"7-14"},"PeriodicalIF":0.0,"publicationDate":"2018-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87591201","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2018-03-10DOI: 10.18869/ACADPUB.JBUMS.20.3.59
محمدرضا صالحی عمران, حمیدرضا وفایی, حسن صالحی عمران
{"title":"بررسی نتایج اکوکاردیوگرافی پس از ترمیم جراحی نارسایی شدید دریچه میترال قلب","authors":"محمدرضا صالحی عمران, حمیدرضا وفایی, حسن صالحی عمران","doi":"10.18869/ACADPUB.JBUMS.20.3.59","DOIUrl":"https://doi.org/10.18869/ACADPUB.JBUMS.20.3.59","url":null,"abstract":"","PeriodicalId":15108,"journal":{"name":"Journal of Babol University of Medical Sciences","volume":"8 1","pages":"59-63"},"PeriodicalIF":0.0,"publicationDate":"2018-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80626071","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2018-03-10DOI: 10.18869/acadpub.jbums.20.3.21
فرزانه چهل چراغی, خاطره عنبری
J Babol Univ Med Sci; 20(3); Mar 2018; PP: 21-8 Received: Sep 26 2017, Revised: Dec 9 2017, Accepted: Jan 9 2018. ABSTRACT BACKGROUND AND OBJECTIVE: Skin flap is one of the most commonly used methods in plastic surgery. Postoperative skin flap necrosis is one of the complications of flap skin. The aim of this study was to evaluate the effect of bone marrow mesenchymal stem cells (BM-MSCs) and chick embryo extract (CEE) on mast cells in a randomized skin flap in rats. METHODS: In this experimental study, 40 male albino Wistar rats weighing 250 – 300 g were divided into four groups of 10 (control, CEE/BM-MSCs, CEE and BM-MSCs). Skin flap (30 × 80 mm) was created behind the animals. Surgery was performed on day zero and therapeutic intervention was done on the same day. Mesenchymal stem cells were extracted from rat bone marrow and were injected. CEE was prepared from a 9-day-old embryo of Marandi chicken. On the seventh day after the surgery, samples were assessed in term of type, and the total number of mast cells (type 1 to 3) in the transfer line. FINDINGS: The difference between the mean number of mast cells type 1 (3.67±1.91) (p=0.99), and type 3 (1.9±1.47) (p=0.384) was not significant in the study groups, but was statistically significant in type 2 (2.27±1.42) in different study groups (p=0.005). There was also a statistically significant difference between the mean total number of mast cells (2.32±0.84) in the BM-MSCs group and other experimental groups (p=0.001). CONCLUSION: Based on the results of this study, increase in mast cell type 2, the improvement of small vessels and decrease in mast cell type 3 lead to the reduction of scarring and fibrosis.
{"title":"ارزیابی بافت شناسی انواع سلول های ماستوسیت در فلاپ پوستی به کمک سلول های بنیادی مزانشیمی مغز استخوان از طریق فاکتور رشد بیو لوژیکی","authors":"فرزانه چهل چراغی, خاطره عنبری","doi":"10.18869/acadpub.jbums.20.3.21","DOIUrl":"https://doi.org/10.18869/acadpub.jbums.20.3.21","url":null,"abstract":"J Babol Univ Med Sci; 20(3); Mar 2018; PP: 21-8 Received: Sep 26 2017, Revised: Dec 9 2017, Accepted: Jan 9 2018. ABSTRACT BACKGROUND AND OBJECTIVE: Skin flap is one of the most commonly used methods in plastic surgery. Postoperative skin flap necrosis is one of the complications of flap skin. The aim of this study was to evaluate the effect of bone marrow mesenchymal stem cells (BM-MSCs) and chick embryo extract (CEE) on mast cells in a randomized skin flap in rats. METHODS: In this experimental study, 40 male albino Wistar rats weighing 250 – 300 g were divided into four groups of 10 (control, CEE/BM-MSCs, CEE and BM-MSCs). Skin flap (30 × 80 mm) was created behind the animals. Surgery was performed on day zero and therapeutic intervention was done on the same day. Mesenchymal stem cells were extracted from rat bone marrow and were injected. CEE was prepared from a 9-day-old embryo of Marandi chicken. On the seventh day after the surgery, samples were assessed in term of type, and the total number of mast cells (type 1 to 3) in the transfer line. FINDINGS: The difference between the mean number of mast cells type 1 (3.67±1.91) (p=0.99), and type 3 (1.9±1.47) (p=0.384) was not significant in the study groups, but was statistically significant in type 2 (2.27±1.42) in different study groups (p=0.005). There was also a statistically significant difference between the mean total number of mast cells (2.32±0.84) in the BM-MSCs group and other experimental groups (p=0.001). CONCLUSION: Based on the results of this study, increase in mast cell type 2, the improvement of small vessels and decrease in mast cell type 3 lead to the reduction of scarring and fibrosis.","PeriodicalId":15108,"journal":{"name":"Journal of Babol University of Medical Sciences","volume":"97 1","pages":"21-28"},"PeriodicalIF":0.0,"publicationDate":"2018-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82749229","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2018-03-10DOI: 10.18869/ACADPUB.JBUMS.20.3.15
الهام شبیری, محمد غریب صالحی, محسن فتاحی باوندپور, جمال حسینی
{"title":"ارتباط نئوواسکولاریزاسیون آندومتریومای تخمدانی با شدت درد لگنی","authors":"الهام شبیری, محمد غریب صالحی, محسن فتاحی باوندپور, جمال حسینی","doi":"10.18869/ACADPUB.JBUMS.20.3.15","DOIUrl":"https://doi.org/10.18869/ACADPUB.JBUMS.20.3.15","url":null,"abstract":"","PeriodicalId":15108,"journal":{"name":"Journal of Babol University of Medical Sciences","volume":"46 1","pages":"15-20"},"PeriodicalIF":0.0,"publicationDate":"2018-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82634410","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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