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Integrating Ayurveda and modern mainstream medicine 阿育吠陀与现代主流医学相结合。
IF 1.7 Q3 INTEGRATIVE & COMPLEMENTARY MEDICINE Pub Date : 2024-09-01 DOI: 10.1016/j.jaim.2024.100997
K.P. Mohanan
This article is an attempt to understand the challenge of integrating the education provided by BAMS programs and MBBS programs, in order to initiate the process of integrating research and practice in Ayurveda and Modern Mainstream Medicine. The specific issues discussed in the article are framed within the broader context of the challenge of integrating any two bodies of knowledge, theories, or knowledge systems in education and research.
这篇文章试图了解将印度医学和印度医学科学院(BAMS)提供的教育与印度医学和印度医学科学院(MBBS)提供的教育相结合所面临的挑战,从而启动阿育吠陀与现代主流医学研究与实践相结合的进程。文章中讨论的具体问题是在将任何两种知识体系、理论或知识体系整合到教育和研究中这一更广泛的背景下提出的。
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引用次数: 0
Ayurinformatics Laboratory- A synergy platform for Ayurveda and technology Ayurinformatics 实验室--阿育吠陀与技术的协同平台。
IF 1.7 Q3 INTEGRATIVE & COMPLEMENTARY MEDICINE Pub Date : 2024-09-01 DOI: 10.1016/j.jaim.2024.101019
Prashant Kumar Gupta , Tanuja Manoj Nesari

The Ayush sector has attained buoyant growth in the past decade as a science, public health, medicine, and industry. Artificial Intelligence, computational drug designing, and other combinatorial techniques could further accelerate the sector's growth. In this edition, we delve into the confluence of Ayurveda and technology, a theme that resonates profoundly in the contemporary healthcare and wellness landscape. The fusion of Ayurveda, an ancient system of medicine rooted in holistic well-being, with cutting-edge technology, is not just a paradigm shift but a necessary evolution in pursuing an integrated healthcare system where all systems have their defined, recognized, and respected contribution. Here, We are highlight one-such fusion initiative "Ayurinformatics Laboratory".

作为一门科学、公共卫生、医学和工业,阿育什学在过去十年中取得了蓬勃发展。人工智能、计算药物设计和其他组合技术将进一步加速该行业的发展。在本版中,我们将深入探讨阿育吠陀与技术的融合,这一主题在当代医疗保健和健康领域引起了深刻共鸣。阿育吠陀是一种植根于整体健康的古老医学体系,它与尖端技术的融合不仅是一种模式的转变,也是追求综合医疗体系的必要发展,在这种体系中,所有系统都有其明确、公认和受尊重的贡献。在此,我们重点介绍 "阿育信息学实验室 "这一融合举措。
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引用次数: 0
Introduction of journal clubs for UG students of Ayurveda, a dire necessity 为阿育吠陀学本科生开设期刊俱乐部是当务之急
IF 1.7 Q3 INTEGRATIVE & COMPLEMENTARY MEDICINE Pub Date : 2024-09-01 DOI: 10.1016/j.jaim.2024.100977
Gaurav Soni
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引用次数: 0
Effects of Raupya Suvarna Sutashekhara, a herbo-mineral-metallic formulation as adjunct Oral Ayurvedic Medicine on long-term survival in patients of malignant brain tumor Raupya Suvarna Sutashekhara(一种辅助口服阿育吠陀药的矿物金属制剂)对恶性脑肿瘤患者长期生存的影响
IF 1.7 Q3 INTEGRATIVE & COMPLEMENTARY MEDICINE Pub Date : 2024-09-01 DOI: 10.1016/j.jaim.2024.101070
Sadanand Sardeshmukh, Vineeta Deshmukh, Arvind Kulkarni, Swapna Kulkarni, Vasanti Godse, Shrinivas Datar, Sushama Bhuvad, Shweta Gujar, Sameer Gore, Bhagyashree Sardeshmukh, Vinita Awalkanthe, Anita Shingte, Sneha Dalvi, Vijay Radye, Sandeep Chavan

Background

The incidence of brain tumors poses a significant threat, particularly with high-grade tumors that exhibit rapid growth and can significantly impair the patient's quality of life, despite treatment modalities. Ayurveda, a natural system of medicines helps to enhance health benefits when used as a complementary therapy in combination with conventional treatment through various herbal, herbo-mineral or herbo-mineral-metallic formulations. One of such formulations, Raupya Suvarna Sutshekhara (RSS), has Raupya bhasma and Suvarna bhasma (incinerated Silver and Gold respectively) ingredients and they are described as Rasayana (immunomodulatory) and possess Medhya (enhances the brain functions and intelligence) activity.

Objective

The study documents effects of Raupya Suvarna Sutshekhara in alleviating symptoms of malignant brain tumors.

Materials and methods

This retrospective cohort study was done for malignant brain tumor patients (n = 110) registered at our centre who were treated with Raupya Suvarna Sutshekhara 125 mg–250 mg (a herbo-mineral metallic formulation) as a treatment of choice of neural tonic along with supporting Ayurvedic medicines. Treatment response evaluation period ranged from 3 months to 5 years (median period 29 weeks). Clinical symptoms, weight, Karnofsky Performance Score (KPS), Quality of Life (QoL) score, and survival data with respect to treatment with RSS were analyzed.

Results

RSS showed a very significant (p < 0.001) effect on symptoms related to memory loss, headache, imbalance, loss of appetite, and generalized weakness while significant (p < 0.05) decrease in urinary incontinence, seizures, difficulty in thinking/articulating, and weakness in one part/side of the body. However, a not-quite significant change was seen in symptom confusion/disorientation. No significant improvement was seen in vision changes, facial numbness or tingling, swallowing difficulties, and tingling in extremities. Body weight and KPS also showed improvement. Patients with treatment between 2 and 5 years showed median survival up to 62 months.

Conclusions

It was observed that adjunct Ayurvedic treatment with RSS helped to reduce the severity of symptoms due to the tumor itself or side-effects of conventional treatments, maintain the quality of life of malignant brain tumor patients and has shown to increase survival with respect to the duration of the treatment.
背景脑肿瘤的发病率构成了重大威胁,尤其是生长迅速的高级别肿瘤,尽管采用了各种治疗方法,但仍会严重影响患者的生活质量。阿育吠陀是一种天然药物系统,它通过各种草药、矿物或矿物-矿物-金属配方作为辅助疗法与传统疗法相结合,有助于提高健康效益。其中一种配方是 Raupya Suvarna Sutshekhara(RSS),含有 Raupya bhasma 和 Suvarna bhasma(分别为焚烧银和金)成分,被称为 Rasayana(免疫调节),具有 Medhya(增强大脑功能和智力)活性。材料和方法这项回顾性队列研究的对象是在本中心登记的恶性脑肿瘤患者(n = 110),他们接受了 Raupya Suvarna Sutshekhara 125 毫克-250 毫克(一种草本矿物质金属制剂)的治疗,作为神经滋补剂的首选治疗方法,同时服用辅助的阿育吠陀药物。治疗反应评估期为 3 个月至 5 年(中位数为 29 周)。结果RSS对记忆力减退、头痛、失衡、食欲不振和全身乏力等相关症状有非常显著的疗效(p <0.001),而对尿失禁、癫痫发作、思维/发音困难和身体某一部分/一侧乏力有显著的疗效(p <0.05)。然而,症状混乱/精神错乱的变化并不明显。视力变化、面部麻木或刺痛、吞咽困难和四肢刺痛等症状没有明显改善。体重和 KPS 也有改善。结论 据观察,RSS 的辅助阿育吠陀疗法有助于减轻因肿瘤本身或常规治疗的副作用而引起的症状的严重程度,保持恶性脑肿瘤患者的生活质量,并在治疗期间提高了生存率。
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引用次数: 0
Ayurveda management of migraine - a case report 偏头痛的阿育吠陀疗法--病例报告。
IF 1.7 Q3 INTEGRATIVE & COMPLEMENTARY MEDICINE Pub Date : 2024-09-01 DOI: 10.1016/j.jaim.2024.100983
Giramalla Patil , Shivanand Patil , Prateek Hosur
Migraine is one of the most prevalent causes of functional disability worldwide. Migraine patients experience headaches of varying degrees, which are related with a higher level of disability and are triggered by psychological and physiological stressors. Migraine is estimated to affect 16.6% of the world's population, with women being three times more likely to experience it than men. Despite considerable advancements in modern and traditional medicine, a complete cure remains uncertain. In Ayurvedic treatises, migraine headache is referred to as Ardhavabedhaka under the classification of Shiroroga (diseases related to the head region).
35-year-old Indian male police inspector, suffering from recurrent right hemi-cranial headaches once in three days for the last three months, presented symptoms of Tridhoshaja Ardhvabhedaka (Migraine) associated with Amlapitta (hyperacidity).
After a thorough assessment of the patient, the treatment was meticulously planned based on the patient's Dosha pradhanyatha and Vyadhi avastha (stage of disease). For the proper Samprapti vighatana, Nidana parivarjana (abstinance from the eitiological factors), Deepana, Paachana, Siravyadha, Nasya and Dosha Shamana Chikitsa principles were adopted. Further, the severity of the migraine was assessed by MIDAS and NPR score, which subsequently decreased from 19 to 4, and the NPR scale decreased from 8 to 2 till completion of the therapeutic intervention.
This case report unequivocally highlights the pivotal role of the Ayurveda treatment regimen in effectively managing migraine. Overall, effective treatment of migraine cases requires the correct assessment of Dosha status and Vyadhi avastha and the correct selection of the appropriate medicine and procedures like Siravyadha and Nasya at that appropriate stage of the disease.
偏头痛是导致全球功能性残疾的最普遍原因之一。偏头痛患者会出现不同程度的头痛,与较高程度的残疾有关,是由心理和生理压力引发的。据估计,偏头痛影响着全球 16.6% 的人口,女性患偏头痛的几率是男性的三倍。尽管现代医学和传统医学都取得了长足的进步,但仍无法彻底治愈偏头痛。在阿育吠陀医学论文中,偏头痛被归入 "Shiroroga"(与头部有关的疾病)分类下的 "Ardhavabedhaka"。35 岁的印度男性警务督察在过去三个月中反复出现右侧半颅骨头痛,三天一次,症状为 Tridhoshaja Ardhvabhedaka(偏头痛),伴有 Amlapitta(胃酸过多)。在对患者进行全面评估后,根据患者的 Dosha pradhanyatha 和 Vyadhi avastha(疾病阶段)精心制定了治疗方案。为了采用适当的 Samprapti vighatana、Nidana parivarjana(戒除致病因素)、Deepana、Paachana、Siravyadha、Nasya 和 Dosha ShamanaChikitsa 原则。此外,通过 MIDAS 和 NPR 评分评估偏头痛的严重程度,偏头痛评分随后从 19 分降至 4 分,NPR 评分从 8 分降至 2 分,直至治疗干预结束。本病例报告明确强调了阿育吠陀疗法在有效控制偏头痛方面的关键作用。总之,要有效治疗偏头痛,就必须正确评估 Dosha 状态和 Vyadhi avastha,并在疾病的适当阶段正确选择适当的药物和程序,如 Siravyadha 和 Nasya。
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引用次数: 0
Ayurvedic management of systemic sclerosis - A case report 系统性硬化症的阿育吠陀疗法--病例报告
IF 1.7 Q3 INTEGRATIVE & COMPLEMENTARY MEDICINE Pub Date : 2024-09-01 DOI: 10.1016/j.jaim.2024.100956
Jagruti R. Parmar , Naiya Upadhyay , Manish V. Patel , Shivenarain N. Gupta

Scleroderma, an autoimmune connective tissue disorder, leads to skin and tissue thickening. In this autoimmune disease condition, the defense mechanism works against the body itself and mistakenly attacks normal cells. Ayurveda links it to vatarakta, initially affecting tvak, rakta, and mamsa. Vata is primarily involved, but as the disease progresses, all doshas and dhatu get involved.

A 45-year-old woman presented with skin hardening, skin depigmentation all over her body, limb stiffness, weakness, arthralgia, anorexia, constipation and burning in the chest region for the last three years.

She was diagnosed with diffuse systemic sclerosis (SSc) but as per Ayurveda we can correlate with aamvata and vatarakta based on her lakshanas(symptoms).

Ayurvedic treatment commenced with vardhamana pippali(Piper longum)rasayan, svedana karma, and virechan karma, followed by basti(enema) chikitsa (pathyadi kvath niruh basti) and oral ayurvedic medication viz., Manjisthadi kvatha, kaishora guggulu, Jatamansi(Nardostachys Jatamansi) churna, mishreya(Foeniculum vulgare) arka, dashang churna with water for local application and daily shamanarth panchtikta ghrit.

After 8 weeks, depigmentation was reduced, new hair growth emerged, mild skin softening occured, chest burning, anorexia, sleeplessness was decreased and enhanced mental well-being.

The treatment aimed to balance vitiated doshas and dhatu while alleviating symptoms, and enhancing overall well-being, demonstrating the efficacy of the holistic approach in managing scleroderma through Ayurveda.

Auto-immune disorder, scleroderma, chronic complications, skin tightness, salt pepper depigmentation, sclerodactyly.

硬皮病是一种自身免疫性结缔组织疾病,会导致皮肤和组织增厚。在这种自身免疫性疾病中,防御机制对身体本身起作用,错误地攻击正常细胞。阿育吠陀将其与 vatarakta 联系在一起,最初会影响 tvak、rakta 和 mamsa。一名 45 岁的女性在过去三年中出现了皮肤变硬、全身皮肤色素沉着、四肢僵硬、无力、关节痛、厌食、便秘和胸部烧灼感。她被诊断为弥漫性系统性硬化症(SSc),但根据阿育吠陀,我们可以根据她的 lakshanas(症状)将其与 aamvata 和 vatarakta 联系起来。阿育吠陀治疗开始于 vardhamana pippali(Piper longum)rasayan、svedana karma 和 virechan karma,随后是 basti(灌肠)chikitsa(patyadi kvath niruh basti)和口服阿育吠陀药物,即:Manjisthadi kvatha、Manjisthadi kvatha、Manjisthadi kvatha、Manjisthadi kvatha、Manjisthadi kvatha、Manjisthadi kvatha、Manjisthadi kvatha、8 周后,患者的色素沉着有所减轻,新的毛发开始生长,皮肤轻度变软,胸部烧灼感、厌食和失眠症状有所减轻,精神状态也有所改善。治疗的目的是平衡受损的道舒和道图,同时减轻症状,提高整体健康水平,这证明了通过阿育吠陀疗法治疗硬皮病的整体方法的有效性。
{"title":"Ayurvedic management of systemic sclerosis - A case report","authors":"Jagruti R. Parmar ,&nbsp;Naiya Upadhyay ,&nbsp;Manish V. Patel ,&nbsp;Shivenarain N. Gupta","doi":"10.1016/j.jaim.2024.100956","DOIUrl":"10.1016/j.jaim.2024.100956","url":null,"abstract":"<div><p>Scleroderma, an autoimmune connective tissue disorder, leads to skin and tissue thickening. In this autoimmune disease condition, the defense mechanism works against the body itself and mistakenly attacks normal cells. Ayurveda links it to <em>vatarakta</em>, initially affecting <em>tvak</em>, <em>rakta</em>, and <em>mamsa</em>. <em>Vata</em> is primarily involved, but as the disease progresses, all <em>doshas</em> and <em>dhatu</em> get involved.</p><p>A 45-year-old woman presented with skin hardening, skin depigmentation all over her body, limb stiffness, weakness, arthralgia, anorexia, constipation and burning in the chest region for the last three years.</p><p>She was diagnosed with diffuse systemic sclerosis (SSc) but as per Ayurveda we can correlate with <em>aamvata</em> and <em>vatarakta</em> based on her <em>lakshanas</em>(symptoms).</p><p>Ayurvedic treatment commenced with <em>vardhamana pippali</em>(<em>Piper longum</em>)<em>rasayan</em>, <em>svedana karma</em>, and <em>virechan karma</em>, followed by <em>basti</em>(enema) <em>chikitsa (pathyadi kvath niruh basti)</em> and oral ayurvedic medication viz., <em>Manjisthadi kvatha</em>, <em>kaishora guggulu</em>, <em>Jatamansi(Nardostachys Jatamansi) churna, mishreya(Foeniculum vulgare) arka, dashang churna</em> with water for local application and daily <em>shamanarth panchtikta ghrit.</em></p><p>After 8 weeks, depigmentation was reduced, new hair growth emerged, mild skin softening occured, chest burning, anorexia, sleeplessness was decreased and enhanced mental well-being.</p><p>The treatment aimed to balance vitiated doshas and dhatu while alleviating symptoms, and enhancing overall well-being, demonstrating the efficacy of the holistic approach in managing scleroderma through Ayurveda.</p><p>Auto-immune disorder, scleroderma, chronic complications, skin tightness, salt pepper depigmentation, sclerodactyly.</p></div>","PeriodicalId":15150,"journal":{"name":"Journal of Ayurveda and Integrative Medicine","volume":"15 5","pages":"Article 100956"},"PeriodicalIF":1.7,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0975947624000718/pdfft?md5=da9d36f463e172d0440b1f4e0ad8b25e&pid=1-s2.0-S0975947624000718-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142270914","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A multi-center, randomized, open label, two-arm study to evaluate safety & efficacy of nutraceutical tablet as adjuvant when compared with standard of care in patients with benign prostatic hyperplasia 这是一项多中心、随机、开放标签、双臂研究,旨在评估良性前列腺增生患者将营养保健品片剂作为辅助治疗与标准治疗相比的安全性和有效性。
IF 1.7 Q3 INTEGRATIVE & COMPLEMENTARY MEDICINE Pub Date : 2024-09-01 DOI: 10.1016/j.jaim.2024.100971
Suresh B. Patankar , Anupama Patankar , Sagar Patankar , Rajesh Raje , Chandu Devanpally , Pranjal Ausekar , GauravPatil , Shraddha Chitale

Background

Benign Prostrate Hyperplasia (BPH) is a progressive disease of ageing men that may be associated with enlargement of the prostate and lower urinary tract symptoms (LUTS). Herbal/Nutraceutical formulations in addition to standard of care (SOC) could alleviate the symptoms, and thus improve the quality of life of patients.

Objectives

To evaluate safety & efficacy of nutraceutical tablet as an adjuvant with SOC.

Materials and Methods

This was a prospective, randomized two-arm study aimed to assess the safety and efficacy of Herbal/Nutraceutical Formulation (IP) + SOC versus only SOC, in BPH patients. The primary efficacy endpoint was the change in international prostate symptom score (IPSS) within and between two arms. The safety was evaluated in terms of adverse events and change in prostate specific antigen (PSA) levels.

Results

140 eligible patients (70 / arm) were evaluated for efficacy and safety endpoints. The baseline characteristics of patients in two arms differed nonsignificantly. The change in IPSS-storage, voiding and QoL scores, from day 1 to 90 were statistically significant in both the arms (p < 0.0001). However, by day 90, the change in these scores in SOC+IP arm were significantly higher than that of SOC arm. Further, the change in International Index of Erectile Function (IIEF) scores was significant in SOC+IP arm (p < 0.05), while non-significant in SOC arm. The adverse events non-significantly differed between two arms.

Conclusion

The herbal/nutraceutical formulation combined with SOC are safe and effective for the treatment of BPH. The combination therapy was effective in reducing urine-related symptoms and improving the QoL of BPH patients.
背景:良性前列腺增生症(BPH)是一种渐进性老年男性疾病,可能与前列腺增生和下尿路症状(LUTS)有关。除标准治疗(SOC)外,草药/保健品配方可减轻症状,从而改善患者的生活质量:材料与方法:这是一项前瞻性随机对照研究:这是一项前瞻性随机双臂研究,旨在评估前列腺增生症患者服用草药/保健品制剂(IP)+SOC 与仅服用 SOC 的安全性和有效性。主要疗效终点是两组患者体内和两组之间国际前列腺症状评分(IPSS)的变化。安全性则根据不良事件和前列腺特异性抗原(PSA)水平的变化进行评估:对 140 名符合条件的患者(70 人/组)进行了疗效和安全性终点评估。两组患者的基线特征差异不大。从第 1 天到第 90 天,两组患者的 IPSS-储尿、排尿和 QoL 评分的变化均有统计学意义(P < 0.0001)。然而,到第 90 天,SOC+IP 治疗组的这些评分变化明显高于 SOC 治疗组。此外,国际勃起功能指数(IIEF)评分的变化在 SOC+IP 组显著(p < 0.05),而在 SOC 组不显著。两组的不良反应差异不显著:结论:草药/保健品配方与SOC联合治疗良性前列腺增生症安全有效。联合疗法能有效减轻良性前列腺增生患者的尿相关症状,改善其生活质量。
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引用次数: 0
Integrating Ayurvedic philosophy with modern technologies for drug research and development: A critical need of mechanistic insights for wider acceptability 将阿育吠陀哲学与现代药物研发技术相结合:亟需深入了解机理,以获得更广泛的可接受性。
IF 1.7 Q3 INTEGRATIVE & COMPLEMENTARY MEDICINE Pub Date : 2024-09-01 DOI: 10.1016/j.jaim.2024.100954
Chavan Sandeep , Vidya Gupta , Vineeta Deshmukh , Sadanand Sardeshmukh
Ayurveda is a holistic science emphasizing healing and maintaining harmony and balance in the body. Medicines from natural resources and in pre-defined dosage forms are integral parts of successful Ayurvedic treatment in various diseases including complex ailments, such as cancer. Ayurvedic medicines are cocktails of several active phyto-compounds and/or natural resources and no isolated/purified molecules are used in the treatment. However, various unique methods employed using natural media, such as water, lipids, buttermilk, and lemon juice, just to name a few, lead to the elimination of unwanted constituents/impurities and enhance the bioavailability and efficacy of the drug. Such plausible alterations, selection, and/or retention of signature phytocompounds in the raw materials, during the process, and in the final drug need to be studied for precise product identification and analysis. Critical standardization of the manufacturing procedures is, therefore, mandatory for quality fidelity, assurance, and optimum efficacy. Moreover, the simultaneous multi-level and/or multi-targeted actions of Ayurvedic medicines against various dysfunctions due to their complex nature makes it extremely challenging to understand the mechanistic aspects during pre-clinical and clinical studies.
The present article focuses on probable challenges and ideal roadmaps for standardization and characterization of such herbal as well as metallic-mineral Ayurvedic medicines being used for various simple and complex diseases like cancer and their treatments. It is emphasized that Ayurvedic manufacturing procedures should be followed meticulously and the finished product be characterized thoroughly using advanced pharmaceutical and analytical techniques. It is also accentuated that detailed monographs or dossiers including shelf-life studies need to be officially published for knowledge dissemination and worldwide acceptance. Finally, safety and efficacy studies as per modern pharmacology ought to be conducted in suitable animal models for the judicious use of these medicines. Mainstream or adjuvant treatment of dreadful diseases such as cancer with Ayurvedic medicines will only be fruitful through rational experimentation and ethical reporting.
阿育吠陀是一门整体科学,强调治疗和保持身体的和谐与平衡。来自天然资源的药物和预先确定的剂型是阿育吠陀疗法成功治疗各种疾病(包括癌症等复杂疾病)不可或缺的组成部分。阿育吠陀药物是几种活性植物化合物和/或自然资源的混合体,治疗中不使用分离/提纯的分子。不过,阿育吠陀药物采用各种独特的方法,利用天然介质(如水、脂质、酪乳和柠檬汁等)去除不需要的成分/杂质,提高药物的生物利用度和疗效。需要对原材料、加工过程和最终药物中的此类似是而非的改变、选择和/或特征植物化合物的保留进行研究,以便对产品进行精确的鉴定和分析。因此,为了保证质量的真实性、可靠性和最佳疗效,必须对生产程序进行严格的标准化。此外,由于阿育吠陀药物性质复杂,同时具有多层次和/或多靶点作用,可用于治疗各种功能障碍,因此在临床前和临床研究中了解其机理方面的问题极具挑战性。本文重点介绍了用于癌症等各种简单和复杂疾病及其治疗的阿育吠陀草药和金属矿物药在标准化和表征方面可能面临的挑战和理想的路线图。文章强调,应严格遵守阿育吠陀药的生产程序,并利用先进的制药和分析技术对成品进行彻底表征。此外,还强调需要正式出版详细的专著或档案,包括保质期研究,以传播知识并为全世界所接受。最后,还应在合适的动物模型中进行现代药理学的安全性和有效性研究,以便合理使用这些药物。只有通过合理的实验和合乎伦理的报告,阿育吠陀药物对癌症等可怕疾病的主流或辅助治疗才能取得成效。
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引用次数: 0
Ayurvedic management of hemangiomatous ulcer: A case report 阿育吠陀疗法治疗血管瘤性溃疡:病例报告
IF 1.7 Q3 INTEGRATIVE & COMPLEMENTARY MEDICINE Pub Date : 2024-09-01 DOI: 10.1016/j.jaim.2024.101056
Praveen Kumar Yadav , Laxmikant S.D.
The most frequent infantile tumor is a hemangioma, and its most common complication is ulceration. A quickly progressing ulcer called a hemangioma can also result in secondary infection. The mechanism of ulcer formation is unknown but is thought to develop during the rapid growth phase. Infantile hemangiomas are diagnosed clinically, based on the progression of the lesion's history and a clinical examination. Physical interventions (laser surgery, cryosurgery, excision) and systemic corticosteroids or beta-blockers are the usual course of treatment; all carry the potential for substantial side effects. A two-month young female baby approached us, with a diagnosis of hemangiomatous ulcer. Skin grafting was advised by a plastic surgeon, but the baby's parents approached for Ayurveda treatment. The case was treated with oral medicine bilwadi agada and external treatments vranaprakshalana with triphala kwatha and jatyadi taila local application for 2 months. There was complete healing of the ulcer.
最常见的婴儿肿瘤是血管瘤,其最常见的并发症是溃疡。称为血管瘤的溃疡进展迅速,也可能导致继发感染。溃疡形成的机制尚不清楚,但据认为是在快速生长期形成的。婴儿血管瘤是根据病史和临床检查的进展情况进行临床诊断的。物理干预(激光手术、冷冻手术、切除术)和全身用皮质类固醇激素或β-受体阻滞剂是通常的治疗方法,但所有这些方法都可能产生很大的副作用。我们接诊了一名两个月大的女婴,诊断为血管瘤性溃疡。整形外科医生建议进行植皮手术,但婴儿的父母要求进行阿育吠陀治疗。该病例接受了为期 2 个月的口服药物 bilwadi agada 和外用疗法 vranaprakshalana 以及 triphala kwatha 和 jatyadi taila 局部涂抹。溃疡完全愈合。
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引用次数: 0
Antibacterial and cytotoxicity properties of a polyherbal mouthwash containing Achyranthes aspera and Trachyspermum ammi against selected periodontal pathogens 含有牛膝和Trachyspermum ammi的多草本漱口水对特定牙周病原体的抗菌和细胞毒性特性。
IF 1.7 Q3 INTEGRATIVE & COMPLEMENTARY MEDICINE Pub Date : 2024-09-01 DOI: 10.1016/j.jaim.2024.101046
Ram Surath Kumar , Anil V. Ankola , Mahantesh B. Nagamoti , Roopali M. Sankeshwari , Kishori P. Sutar , Shushant I. Jigan , Atrey J. Pai Khot

Background

Chlorhexidine (CHX) is considered as a gold standard for its antibacterial efficacy and substantivity in chemical plaque control. However, some adverse effects are associated with its prolonged use. Herbal medicines like Achyranthes aspera and Trachyspermum ammi have been used in many clinical conditions, and they appear to be a valuable substitute next to CHX in the management of periodontal diseases.

Objective

This in vitro study was designed to assess and compare the antibacterial potential and cytotoxic effects of novel polyherbal mouthwash containing A. aspera and T. ammi with 0.2% CHX mouthwash against Porphyromonas gingivalis, Tannerella forsythia, and Aggregatibacter actinomycetemcomitans.

Methods

Ethanolic extracts of A. aspera and T. ammi were prepared by the Soxhlet apparatus method and were subjected to preliminary phytochemical screening. The individual plant extracts and the plant extract mixture (PEM) of A. aspera and T. ammi in the ratio of 1:1, 2:1, 1:2 (w/v) were assessed for minimum inhibitory concentration (resazurin microtitre assay) and minimum bactericidal concentration (spread plating method) against selected periodontal pathogens in comparison to CHX. The polyherbal mouthwash was assessed for zone of inhibition (well diffusion method) and cytotoxicity (MTT assay) on adult human gingival fibroblasts. All the experiments were performed in triplicate.

Results

The antibacterial activity was evident in the PEMs, and polyherbal mouthwash against tested periodontal pathogens and was comparable to CHX. The cytotoxicity assay findings confirmed that polyherbal mouthwash exhibited 82.1% of surviving cells which proved good biocompatibility.

Conclusion

A. aspera and T. ammi based mouthwash possess comparable antibacterial activity against periodontal pathogens when compared to CHX.
背景:洗必泰(CHX)因其抗菌功效和在化学牙菌斑控制方面的有效性而被视为黄金标准。然而,长期使用会产生一些不良反应。Achyranthes aspera 和 Trachyspermum ammi 等草药已在许多临床病例中使用,在牙周疾病的治疗中,它们似乎是 CHX 的重要替代品:本体外研究旨在评估和比较含有香紫苏和安米的新型多草本漱口水与 0.2% CHX 漱口水对牙龈卟啉单胞菌、连翘菌和放线菌的抗菌潜力和细胞毒性作用:用索氏提取器法制备了 A. aspera 和 T. ammi 的乙醇提取物,并对其进行了初步的植物化学筛选。以 1:1、2:1、1:2(w/v)的比例分别评估了天南星和安米的单个植物提取物和植物提取物混合物(PEM)对选定牙周病原体的最小抑菌浓度(雷沙唑啉微滴定法)和最小杀菌浓度(涂布平板法),并与 CHX 进行了比较。评估了多草本漱口水对成人牙龈成纤维细胞的抑制区(井扩散法)和细胞毒性(MTT 法)。所有实验均一式三份:结果:PEMs 和多草本漱口水对测试的牙周病原体具有明显的抗菌活性,与 CHX 不相上下。细胞毒性试验结果表明,多草本漱口水中存活细胞的比例为 82.1%,证明其具有良好的生物相容性:结论:与 CHX 相比,A. aspera 和 T. ammi 漱口水对牙周病原体具有相当的抗菌活性。
{"title":"Antibacterial and cytotoxicity properties of a polyherbal mouthwash containing Achyranthes aspera and Trachyspermum ammi against selected periodontal pathogens","authors":"Ram Surath Kumar ,&nbsp;Anil V. Ankola ,&nbsp;Mahantesh B. Nagamoti ,&nbsp;Roopali M. Sankeshwari ,&nbsp;Kishori P. Sutar ,&nbsp;Shushant I. Jigan ,&nbsp;Atrey J. Pai Khot","doi":"10.1016/j.jaim.2024.101046","DOIUrl":"10.1016/j.jaim.2024.101046","url":null,"abstract":"<div><h3>Background</h3><div>Chlorhexidine (CHX) is considered as a gold standard for its antibacterial efficacy and substantivity in chemical plaque control. However, some adverse effects are associated with its prolonged use. Herbal medicines like <em>Achyranthes aspera</em> and <em>Trachyspermum ammi</em> have been used in many clinical conditions, and they appear to be a valuable substitute next to CHX in the management of periodontal diseases.</div></div><div><h3>Objective</h3><div>This <em>in vitro</em> study was designed to assess and compare the antibacterial potential and cytotoxic effects of novel polyherbal mouthwash containing <em>A. aspera</em> and <em>T. ammi</em> with 0.2% CHX mouthwash against <em>Porphyromonas gingivalis, Tannerella forsythia,</em> and <em>Aggregatibacter actinomycetemcomitans</em>.</div></div><div><h3>Methods</h3><div>Ethanolic extracts of <em>A. aspera</em> and <em>T. ammi</em> were prepared by the Soxhlet apparatus method and were subjected to preliminary phytochemical screening. The individual plant extracts and the plant extract mixture (PEM) of <em>A. aspera</em> and <em>T. ammi</em> in the ratio of 1:1, 2:1, 1:2 (<em>w/v</em>) were assessed for minimum inhibitory concentration (resazurin microtitre assay) and minimum bactericidal concentration (spread plating method) against selected periodontal pathogens in comparison to CHX. The polyherbal mouthwash was assessed for zone of inhibition (well diffusion method) and cytotoxicity (MTT assay) on adult human gingival fibroblasts. All the experiments were performed in triplicate.</div></div><div><h3>Results</h3><div>The antibacterial activity was evident in the PEMs, and polyherbal mouthwash against tested periodontal pathogens and was comparable to CHX. The cytotoxicity assay findings confirmed that polyherbal mouthwash exhibited 82.1% of surviving cells which proved good biocompatibility.</div></div><div><h3>Conclusion</h3><div><em>A. aspera</em> and <em>T. ammi</em> based mouthwash possess comparable antibacterial activity against periodontal pathogens when compared to CHX.</div></div>","PeriodicalId":15150,"journal":{"name":"Journal of Ayurveda and Integrative Medicine","volume":"15 5","pages":"Article 101046"},"PeriodicalIF":1.7,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142466220","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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Journal of Ayurveda and Integrative Medicine
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