Journal of Ayurveda and Integrative Medicine最新文献

{"title":"Exploring the interaction hotspots of p-glycoprotein with herbal bioactives: In silico insights for integrative Ayurvedic therapeutics","authors":"Chandana Roy,&nbsp;Pratiti Ghosh","doi":"10.1016/j.jaim.2025.101238","DOIUrl":"10.1016/j.jaim.2025.101238","url":null,"abstract":"<div><h3>Background</h3><div>The human multidrug resistant efflux transporter p-glycoprotein plays a crucial role in the pharmacokinetics of xenobiotics, mediating their elimination from systemic circulation. Its overexpression contributes to multidrug resistance, posing challenges to effective therapeutic interventions.</div></div><div><h3>Objectives</h3><div>This study integrates Ayurvedic and contemporary biomedical research to investigate hotspot residues involved in the interaction of p-glycoprotein with bioactives from medicinal herbs to enhance the understanding of its substrate recognition and transport mechanisms.</div></div><div><h3>Material and methods</h3><div>The 3D structure of 6C0V was docked with 789 herbal ligand molecules utilizing the CDOCKER programme in Biovia Discovery Studio (version 4.5, 2021), revealing key residues involved in binding interactions. Alanine scanning mutagenesis was performed to evaluate the functional importance of these residues by analyzing changes in binding affinity through molecular docking.</div></div><div><h3>Result</h3><div>The study identified residues Ser979, Glu972, Leu332, Phe336, Leu976, Thr76, Leu975, Gly737 and Phe732 as potential hotspots for binding and inhibition of ligand efflux into the extracellular compartment. Targeting these energetically important residues with herbal compounds can guide the development of small-molecule drugs that bind with high specificity and reduce off-target interactions, minimizing undesirable side effects.</div></div><div><h3>Conclusion</h3><div>This study provides insight into the structural basis of p-glycoprotein-herbal ligand interactions, aiding in the design of specific plant-based inhibitors for overcoming multidrug resistance in treatment of chronic diseases.</div></div>","PeriodicalId":15150,"journal":{"name":"Journal of Ayurveda and Integrative Medicine","volume":"16 6","pages":"Article 101238"},"PeriodicalIF":1.9,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145409278","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ayurvedic management for Epidermolysis bullosa - A case report","authors":"K.M. Pratap Shankar ,&nbsp;Midhuna Mohan K","doi":"10.1016/j.jaim.2025.101255","DOIUrl":"10.1016/j.jaim.2025.101255","url":null,"abstract":"<div><div>Epidermolysis bullosa (EB) is an inherited or auto-immunity-mediated, heterogeneous group of rare genetic dermatoses characterized by fragile skin and mucosae with blister formation induced by minimal trauma. Junctional Epidermolysis Bullosa (JEB) is an autosomal recessive inherited subtype of EB with higher chances of malnutrition and nail involvement. Considering the key factors such as genetic disposition, chronicity, pathology, involvement of deeper tissues, and complexities, EB may be considered as <em>Kustha</em> (spectrum of diseases of the integumentary system) from an Ayurvedic perspective. A 34-year-old male patient diagnosed with JEB presented with a history of persistent non-healing ulcers, recurrent blisters, and bullae, usually occurring after minor trauma since the age of three months. The ulcers, scars, and lesions were widespread, covering approximately two-thirds of the body. After a thorough understanding of the Ayurvedic pathology of the disease, <em>Shamana</em> (pacifying therapy) and <em>Shodhana</em> (purificatory therapy) procedures were administered. Later, <em>raktamoshana</em> (Blood-letting through venesection and <em>jalaukavacharana</em>) was also employed. During the treatment and follow-up period, the episodes of new blister formations drastically reduced, and the ulcer formed from occasional blisters healed quickly without crusting. There was a considerable reduction in wound surface area. The patient's personal and social interactions improved. Quality of Life assessed through the Dermatology Life Quality Index (DLQI) showed improvement. The present case of JEB was effectively managed using various Ayurvedic treatment modalities. Understanding the Ayurvedic pathology and tailoring treatment strategies can yield better results in chronic, debilitating autoimmune dermatological conditions such as EB.</div></div>","PeriodicalId":15150,"journal":{"name":"Journal of Ayurveda and Integrative Medicine","volume":"16 6","pages":"Article 101255"},"PeriodicalIF":1.9,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145504412","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pedagogy experiments for Ayush academia","authors":"Girish Tillu","doi":"10.1016/j.jaim.2025.101273","DOIUrl":"10.1016/j.jaim.2025.101273","url":null,"abstract":"","PeriodicalId":15150,"journal":{"name":"Journal of Ayurveda and Integrative Medicine","volume":"16 5","pages":"Article 101273"},"PeriodicalIF":1.9,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145091468","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Development of an instrument for screening mental health based on Ayurvedic concept of Triguna","authors":"K.N. Ananda Lakshmy ,&nbsp;M.A. Shajahan","doi":"10.1016/j.jaim.2025.101175","DOIUrl":"10.1016/j.jaim.2025.101175","url":null,"abstract":"&lt;div&gt;&lt;h3&gt;Background&lt;/h3&gt;&lt;div&gt;As the bio-regulatory principles (&lt;em&gt;Dosha&lt;/em&gt;) are the essential components of the body, the three attributes (&lt;em&gt;Triguna&lt;/em&gt;)-&lt;em&gt;Satva, Raja&lt;/em&gt;, and &lt;em&gt;Tamas&lt;/em&gt; are the crucial components of the mind that determine an individual's mental status. Though &lt;em&gt;Triguna&lt;/em&gt;-based psychological assessment tools are available, there are no standardized tools to evaluate mental health using this unique Ayurvedic approach.So this research was undertaken to create a simple, self-administering instrument for screening mental health based on Ayurvedic concept-&lt;em&gt;Triguna&lt;/em&gt;.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Objective&lt;/h3&gt;&lt;div&gt;To develop a simple, reliable, and valid self-administering instrument based on &lt;em&gt;Triguna&lt;/em&gt; concept of Ayurvedic classics for screening mental health.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Methods&lt;/h3&gt;&lt;div&gt;Standard steps to develop the instrument -Conceptualization, item generation, item selection, item wording, Translation-back translation, pre-test, pilot study, Test-retest were done before the final administration of the draft instrument. Reliability and validity testing were carried out. Reliability assessment included Test-retest and internal consistency. Face, content, construct, criterion and convergent validity were done as part of the validity assessment. Exploratory factor analysis using Principal Component Analysis with Varimax rotation was employed for construct validation and item reduction. A cross-sectional study employing a stratified, multi-stage cluster sampling technique was conducted among 400 participants aged 20–40 years, representing rural, urban and coastal areas of Thiruvananthapuram, Kerala, India. The criterion validity of the newly developed tool was assessed against the WHO Subjective Well-being Inventory(SUBI).The reference standard, evaluated for its diagnostic properties including sensitivity, specificity, predictive values, and likelihood ratios, was administered alongside the draft instrument. After appropriate analyses, a 38-item self-administering instrument was developed and named as Mental Health Assessment Scale with &lt;em&gt;Triguna&lt;/em&gt; (MHAS-TG). Hypothesis validation and construct validity were assessed using diverse community samples, comprising 100 individuals from various geographical areas of Kannur District, 100 students from NIT Calicut (Kozhikode) and 50 ex-convicts from Kannur District.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Results&lt;/h3&gt;&lt;div&gt;The newly developed 38-item Mental Health self-Assessment Scale with &lt;em&gt;Triguna&lt;/em&gt; (MHAS-TG) is presented as a discriminating tool that showed high Test-retest (Intra Class Correlation coefficient - 0.8) and Internal consistency reliability (Cronbach's alpha = 0.9). The tool had adequate face validity and content validity (Content validity index- 0.84). Construct validity by Exploratory factor analysis yielded 38 items of 9-factor solution with a cumulative variance of 58.06 %. The self-administering tool with a score range of 0–114 derived a cut-off sc","PeriodicalId":15150,"journal":{"name":"Journal of Ayurveda and Integrative Medicine","volume":"16 5","pages":"Article 101175"},"PeriodicalIF":1.9,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144779299","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hashimoto's thyroiditis and hypothyroidism, treated with Shamana Chikitsa principles of Panduroga – A case report","authors":"P.K.V. Anand,&nbsp;Vaishali Deshpande","doi":"10.1016/j.jaim.2025.101172","DOIUrl":"10.1016/j.jaim.2025.101172","url":null,"abstract":"<div><div>Hypothyroidism as a sequel to Hashimoto's thyroiditis is a very common thyroid illness. The conventional treatment is replacement of thyroid hormone to compensate insufficient production from the gland. The clinical features manifested is of widely variable intensity and may not be proportionate always to the blood levels of hormones. The disease does not have a direct mention in Ayurvedic classics. In such instances, treatment principle is adopted from the principles of treatment mentioned for those diseases which holds a similarity in etiopathogenesis, based on the clinical presentations and Dosha-Dooshya analysis. Thus, treatment principles of various diseases such as Galagandam, Agnimandyam, Sthoulyam etc., are being used for the treatment of thyroid diseases. A case of hypothyroidism presented with clinical features similar to Pandurogam was managed with the medicines described in the context of Pandurogam and Sopham. Higher TSH levels were brought to normal limits and high anti thyroid peroxidase level was reduced with a set of Ayurvedic medicines for a longer duration. Keeping away from the popular translation of Pandurogam as Anemia, a symptom oriented diagnostic work up based exclusively on the Ayurvedic classics, followed by symptom-oriented selection of medicines suited to the diagnosis is effective in reducing both symptoms and blood values. This gives the hope of managing hypothyroidism with alternate treatment methods other than supplementation of hormone for lifelong.</div></div>","PeriodicalId":15150,"journal":{"name":"Journal of Ayurveda and Integrative Medicine","volume":"16 5","pages":"Article 101172"},"PeriodicalIF":1.9,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144916669","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prakriti elucidates the inter-individual variability in coronary artery disease risk-predicting biomarkers: A tertiary care hospital-based case control study","authors":"Pamila Dua ,&nbsp;Bhavana Prasher ,&nbsp;Sandeep Seth ,&nbsp;Shivam Pandey ,&nbsp;Subir Kumar Maulik ,&nbsp;K.H. Reeta","doi":"10.1016/j.jaim.2025.101178","DOIUrl":"10.1016/j.jaim.2025.101178","url":null,"abstract":"<div><h3>Background</h3><div>Several biochemical tests and biomarkers are well-known for the assessment of risk towards coronary artery disease (CAD). However, conflicting results pose a significant challenge probably due to phenotypic heterogeneity. In Ayurveda, individuals are classified into phenotypes- <em>Prakriti,</em> which helps in predicting an individual's susceptibility to disease, its prognosis and selection of therapy. In the present study, an attempt was made to overcome this challenge with an aim to identify the association between different constitution types as mentioned in Ayurveda with biochemical markers for precisely predicting the risks for CAD.</div></div><div><h3>Methods</h3><div>200 clinically stable CAD patients and 100 healthy controls were recruited from the Cardiology OPD, AIIMS, New Delhi, India. A comprehensive set of tests to incorporate various aspects of CAD pathophysiology was performed. Assessment of <em>Prakriti</em> was done clinically and with AI/ML algorithm based validated questionnaire.</div></div><div><h3>Results</h3><div>The monocyte-lymphocyte ratio (MLR), fasting blood sugar, urea, creatinine, uric acid, and NT-pro BNP were significantly higher in CAD patients as compared to healthy controls. <em>Prakriti</em> stratification revealed maximum number of patients with <em>Kapha Prakriti</em>. MLR and IL-6 (associated with inflammatory and peripheral endothelial dysfunction) were high in <em>Vata</em> patients; diabetic control (associated with plaque instability and malfunctioned RAAS) was poor in <em>Kapha</em> patients and NT-pro BNP (associated with myocardial hypoxia) was higher in <em>Pitta</em> patients.</div></div><div><h3>Conclusion</h3><div>Though, several biochemical parameters were associated with risks for CAD, <em>Prakriti</em> classification provided more insights into the precise risks. This dual approach may help in guiding personalized treatment options in CAD management.</div></div>","PeriodicalId":15150,"journal":{"name":"Journal of Ayurveda and Integrative Medicine","volume":"16 5","pages":"Article 101178"},"PeriodicalIF":1.9,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144865078","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Integrating macro-microscopy, DNA barcoding and HPTLC for quality assessment of berberine containing botanicals traded as Maramanjal/Daruharidra","authors":"Sunil Kumar Koppala Narayana ,&nbsp;Pushkar Kaira ,&nbsp;Mahima Karthikeyan ,&nbsp;Murugammal Shanmugam ,&nbsp;Susikumar Sundharamoorthy ,&nbsp;Remya Andalil ,&nbsp;Divya Kallingil Gopi ,&nbsp;Radha Prakasam ,&nbsp;Shakila Ramachandran ,&nbsp;Kanagarajan Arumugam","doi":"10.1016/j.jaim.2025.101192","DOIUrl":"10.1016/j.jaim.2025.101192","url":null,"abstract":"<div><h3>Background</h3><div><em>Daruharidra/Maramanjal</em> is one of the most popular shrub used in Ayurveda, Siddha and other Indian medicinal systems. More than one botanical source is traded under this name, predominantly <em>Berberis aristata</em> and <em>Coscinium fenestratum</em> with an annual trade of 1000–2000 metric tonnes. The herbal drug trade is often reported with misidentification, adulteration and/or substitution issues due to morphological resemblance and confusion in vernacular names. This work aimed to integrate macro-microscopic, DNA marker strategies and phytochemical assay to differentiate <em>Berberis aristata</em> from its traded sources.</div></div><div><h3>Material and methods</h3><div>Thirteen marketed samples and one authentic field sample from natural habitat were collected from various regions of the Indian market under the trade name <em>Maramanjal/Daruharidra</em>. The traditional identification methods included macro-microscopic and phytochemical screening by High-Performance Thin Layer Chromatography (HPTLC). Additionally, DNA barcode-based molecular identification and phylogenetic analysis were done using the ITS2 (Internal Transcribed Spacer 2) marker.</div></div><div><h3>Results</h3><div>The macroscopic observations revealed 80 % ad-mixing of various allied botanicals in addition to accepted north Indian and south Indian sources such as <em>B. aristata</em> and <em>C. fenestratum</em> respectively. DNA barcoding enabled the identification of genuine and adulterated raw drugs from the collected samples. The HPTLC quantification revealed the presence of berberine in all 14 samples varying from 1.12 % to 26.33 %.</div></div><div><h3>Conclusions</h3><div>The macro-micro, HPTLC, and DNA barcoding helped in the identification of adulteration and substitution practices in this highly traded botanical drug. DNA barcoding can prove an effective tool for discovering the adulteration and substitution of <em>Maramanjal/Daruharidra</em> and this is its first report on the application of morphology, microscopy, phytochemical analysis, and DNA markers in differentiating these traded species.</div></div>","PeriodicalId":15150,"journal":{"name":"Journal of Ayurveda and Integrative Medicine","volume":"16 5","pages":"Article 101192"},"PeriodicalIF":1.9,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145044615","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Understanding Atherosclerotic Cardiovascular disease in the light of Ayurveda","authors":"Maanasi Menon ,&nbsp;Sushma Naranappa Salethoor ,&nbsp;Thushara Madathil ,&nbsp;Akhilesh Shukla","doi":"10.1016/j.jaim.2025.101186","DOIUrl":"10.1016/j.jaim.2025.101186","url":null,"abstract":"<div><div>Atherosclerotic cardiovascular disease (ASCVD) is the malady that claims most human lives around the world by literally cutting off their heart's blood supply. Unwholesome diet, sedentary lifestyle and psychological stress are the major risk factors leading to this condition. Even with technological and medical advancements, the burden of this disease has only aggravated further especially with the COVID pandemic also contributing to trigger this condition. There is an urgent need to find better solutions to combat this disease in such circumstances. The Indian traditional healthcare system, Ayurveda has a unique perspective of the heart and heart disease which when understood parallelly along with modern medical knowledge may offer better solutions. The descriptions of <em>Kaphaja Hridroga</em> in Ayurveda can be correlated to ASCVD, and this article is an effort to develop a synergistic understanding of the aetio-pathogenesis of ASCVD in the light of Ayurveda. Ayurveda management principles give more emphasis on prevention and non-pharmacological approaches such as diet and lifestyle modifications along with medical management and these principles of management of <em>Hridroga</em> can be tactfully integrated into conventional therapy for providing a more wholesome care.</div></div>","PeriodicalId":15150,"journal":{"name":"Journal of Ayurveda and Integrative Medicine","volume":"16 5","pages":"Article 101186"},"PeriodicalIF":1.9,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145091455","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Management of Oligo-teratospermia with Vajikarana Chitkitsa resulting in healthy natural conception: A case report.","authors":"Swarda R Uppin, T U Aravinth","doi":"10.1016/j.jaim.2025.101190","DOIUrl":"10.1016/j.jaim.2025.101190","url":null,"abstract":"<p><p>Oligo-teratozoospermia is a condition affecting the normal sperm count and morphology leading to male factor infertility, majorly resulting due to improper lifestyle adaptations. In Ayurveda literature, the condition is well elaborated as Ksheenashukra having specified treatment modalities. This paper presents a case of infertile couple where in the male was diagnosed with Oligo-teratozoospermia, and was advised for ART due to teratogenecity. The patient approached Ayurveda fertility centre and was subjected to Ayurveda treatment with initial counseling, followed by Shodhana chikitsa and 2 courses of Vajikarana aushadhi prayoga. Within 3 months, the outcome resulted from Oligo-teratozoospermia to normozoospermia and the partner conceived within 2 cycles. The female experienced a safe and healthy antenatal phase and the couple was blessed with a baby boy.</p>","PeriodicalId":15150,"journal":{"name":"Journal of Ayurveda and Integrative Medicine","volume":"16 5","pages":"101190"},"PeriodicalIF":1.9,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12355026/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144804178","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A case report on Ayurvedic management of progressive bulbar palsy-A rare amyotrophic lateral sclerosis phenotype","authors":"Sinimol Thekkekkoottumughath Peethambaran ,&nbsp;Abhayadev Ashokan ,&nbsp;Varanasi Subhose","doi":"10.1016/j.jaim.2025.101176","DOIUrl":"10.1016/j.jaim.2025.101176","url":null,"abstract":"<div><div>This case report is the description of a devastating illness, Progressive Bulbar Palsy (PBP) of a sixty-seven years old male patient. He presented with complaints of slurred speech, hearing impairment, generalised weakness of limbs, weakened grip to hold objects in hand, difficulty to walk with normal speed, frequent dizzy feeling while walking, severe fatigue, increased anger, heaviness of head, depression, anxiety, decreased memory and headache for 1 year. When he consulted conventional medicine, in Magnetic Resonance Imaging (MRI) of brain, only ‘Partial empty sella’ and age related mild cerebral atrophy was detected and the patient was diagnosed PBP clinically. They prescribed Riluzole 50 mg tablet twice a day and Fluoxetine 10mg capsules at night time for 3 months, but obtained no relief for symptoms and consulted this Out Patient Department (OPD). In Ayurvedic parlance, PBP resembles conditions like <em>Kaphavruta vata</em>. In this patient, <em>Pittavritavata</em> symptoms like <em>bhrama</em> (∼dizziness) was also present in increased severity. Diagnosis was done with the aid of Gold Coast diagnostic criteria. Internal and external medications with properties alleviating <em>avarana</em> (∼occlusion) of <em>vata</em> by <em>kapha</em> and <em>pitta</em>, <em>shodhana</em> (∼expelling the aggravated doshas and cleanses the body internally), rejuvenating <em>(Rasayana) properties,</em> for overall strengthening of nervous system and musculoskeletal system, enhancing balance and coordination, improving speech and memory were used. The assessment was done before and after the treatment by ‘Amyotrophic Lateral Sclerosis Functional Rating Scale-Revised (ALSFRS-R). The score before and after the treatment was 35 and 45 respectively out of 48. The treatment helped to increase the quality of life exceptionally as symptomatic relief was obtained. As it is a devastating disorder with poor prognosis and most probably will lead to death, it is advisable to repeat the treatments in regular intervals, depending on the recurrence of symptoms, if any.</div></div>","PeriodicalId":15150,"journal":{"name":"Journal of Ayurveda and Integrative Medicine","volume":"16 5","pages":"Article 101176"},"PeriodicalIF":1.9,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144996897","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}