Objective To explore the related factors of subependymal hemorrhage (SEH) and cerebral hemodynamic changes. Methods From October 2012 to October 2017, 200 cases of children with subependymal hemorrhage diagnosed by ultrasound in our department of pediatrics were selected as the observation group , and a total of 150 children who were admitted to the Department of Pediatrics in the same period due to craniocerebral diseases and other serious diseases were selected as control group. The independent risk factors of the children in the observation group were analyzed, and the difference of the maximum systolic blood flow velocity (SV), the diastolic maximum flow velocity (DV), the systolic and diastolic velocity ratio (S/D), the resistance index (RI), and the pulsatile index (PI) were compared between the two groups. Results Neonatal asphyxia, preterm birth, acidosis, neonatal respiratory distress syndrome (NRDS), patent ductus arteriosus and coagulation dysfunction were independent risk factors for subependymal hemorrhage. The bleeding side SV and DV of the observation group were higher than those of the control group, with statistically significant difference (P 0.05). Conclusions Children with ependymal hemorrhage can observe the hemodynamic indexes of anterior cerebral artery (ACA) dynamically by craniocerebral ultrasound, and judge the therapeutic effect by evaluating the systolic and diastolic blood flow velocity, so as to prevent the further aggravation of subependymal hemorrhage Key words: Infant, premature; Subependymal hemorrhage; Hemodynamics; Ultrasonography, doppler, transcranial
{"title":"Application value of intracranial vascular hemodynamics in neonatal subependymal hemorrhage","authors":"Haojie Ning, Dezhan Wei, Jieying Chen, Xueli Wu, Feng Zhang, Yu-Feng Cheng","doi":"10.3760/CMA.J.ISSN.1008-1372.2020.01.015","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1008-1372.2020.01.015","url":null,"abstract":"Objective \u0000To explore the related factors of subependymal hemorrhage (SEH) and cerebral hemodynamic changes. \u0000 \u0000 \u0000Methods \u0000From October 2012 to October 2017, 200 cases of children with subependymal hemorrhage diagnosed by ultrasound in our department of pediatrics were selected as the observation group , and a total of 150 children who were admitted to the Department of Pediatrics in the same period due to craniocerebral diseases and other serious diseases were selected as control group. The independent risk factors of the children in the observation group were analyzed, and the difference of the maximum systolic blood flow velocity (SV), the diastolic maximum flow velocity (DV), the systolic and diastolic velocity ratio (S/D), the resistance index (RI), and the pulsatile index (PI) were compared between the two groups. \u0000 \u0000 \u0000Results \u0000Neonatal asphyxia, preterm birth, acidosis, neonatal respiratory distress syndrome (NRDS), patent ductus arteriosus and coagulation dysfunction were independent risk factors for subependymal hemorrhage. The bleeding side SV and DV of the observation group were higher than those of the control group, with statistically significant difference (P 0.05). \u0000 \u0000 \u0000Conclusions \u0000Children with ependymal hemorrhage can observe the hemodynamic indexes of anterior cerebral artery (ACA) dynamically by craniocerebral ultrasound, and judge the therapeutic effect by evaluating the systolic and diastolic blood flow velocity, so as to prevent the further aggravation of subependymal hemorrhage \u0000 \u0000 \u0000Key words: \u0000Infant, premature; Subependymal hemorrhage; Hemodynamics; Ultrasonography, doppler, transcranial","PeriodicalId":15276,"journal":{"name":"中国医师杂志","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88116240","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-01-20DOI: 10.3760/CMA.J.ISSN.1008-1372.2020.01.008
Xue-mei Fan, Guang-xia Xi, Lingxia Zhao, Kun Yang
Objective To study the association of single nucleotide polymorphism (SNP)276 in adiponectin gene with essential hypertension in population with impaired glucose regulation in Han people of Shanxi region. Methods The study population consisted of 216 Chinese Hans residents with impaired glucose regulation (IGR) in Shanxi province. Polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) was applied to test the adiponectin SNP276G/T polymorphism. Results The distributions of genotypes and alleles of SNP276 both displayed significant difference between the IGR complicating norm tension group and the hypertension group (P=0.025, P=0.007). Compared with the TT genotype, the SNP276 non-TT (GT+ GG) genotype was associated with increased risk of complicating with hypertension (OR=3.346, 95% CI: 1.115-8.986, P=0.037), while after age- , sex- and BMI-adjusted, there was no significant difference between the 2 groups (P=0.349). Conclusions SNP276 in adipose most abundant gene transcript 1 (APM1) was associated with the susceptibility to be complicating essential hypertension in population with impaired glucose regulation in Han people of Shanxi region. Key words: Adiponectin; Polymorphism, single nucleotide; Impaired glucose regulation; Hypertension
{"title":"Association of SNP276 polymorphism in adiponectin gene with essential hypertension in population of Shanxi region with impaired glucose regulation","authors":"Xue-mei Fan, Guang-xia Xi, Lingxia Zhao, Kun Yang","doi":"10.3760/CMA.J.ISSN.1008-1372.2020.01.008","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1008-1372.2020.01.008","url":null,"abstract":"Objective \u0000To study the association of single nucleotide polymorphism (SNP)276 in adiponectin gene with essential hypertension in population with impaired glucose regulation in Han people of Shanxi region. \u0000 \u0000 \u0000Methods \u0000The study population consisted of 216 Chinese Hans residents with impaired glucose regulation (IGR) in Shanxi province. Polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) was applied to test the adiponectin SNP276G/T polymorphism. \u0000 \u0000 \u0000Results \u0000The distributions of genotypes and alleles of SNP276 both displayed significant difference between the IGR complicating norm tension group and the hypertension group (P=0.025, P=0.007). Compared with the TT genotype, the SNP276 non-TT (GT+ GG) genotype was associated with increased risk of complicating with hypertension (OR=3.346, 95% CI: 1.115-8.986, P=0.037), while after age- , sex- and BMI-adjusted, there was no significant difference between the 2 groups (P=0.349). \u0000 \u0000 \u0000Conclusions \u0000SNP276 in adipose most abundant gene transcript 1 (APM1) was associated with the susceptibility to be complicating essential hypertension in population with impaired glucose regulation in Han people of Shanxi region. \u0000 \u0000 \u0000Key words: \u0000Adiponectin; Polymorphism, single nucleotide; Impaired glucose regulation; Hypertension","PeriodicalId":15276,"journal":{"name":"中国医师杂志","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78081173","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-01-20DOI: 10.3760/CMA.J.ISSN.1008-1372.2020.01.019
Liang Chen, Xiudi Han, X. Xing, Xiaoli Zhu
Objective To explore the value of B-type natriuretic peptide (BNP) be used as a prognostic factor for community-acquired pneumonia. Methods This was a multicenter, retrospective study. Data of patients hospitalized with community-acquired pneumonia during 2014/1/1 to 2015/12/31 from four tertiary hospitals were reviewed, including demographic and clinical features, and outcomes. Univariate analysis and logistic regression analysis were performed to determine risk factors for 30-day mortality. Receiver operating characteristic curves (ROCs) was performed to verify the accuracy of BNP>1 000 pg/ml, CURB-65 score and BNP>1 000 pg/ml+ CURB-65 score (B-CURB65) as 30-day mortality predictors in the study patients. Results 1 786 patients hospitalized with community-acquired pneumonia (CAP) were entered into the final analysis. The 30-day mortality was 4.7%. Logistic regression analysis confirmed blood BNP>1 000 pg/ml was an independent risk factor associated with 30-day mortality of CAP patients. The area under the curve (AUC) of B-CURB65 was 0.774, which was higher than CURB-65 score (AUC=0.625, P=0.002). Conclusions Blood BNP is a valuable biomarker related to the 30-day mortality of CAP patients, which can increase the predicting accuracy of CURB-65 score. Key words: Natriuretic peptide, brain; Community-acquired pneumonia; Mortality
{"title":"The assessment of B-type natriuretic peptide be used as a prognositic factor for community-acquired pneumonia","authors":"Liang Chen, Xiudi Han, X. Xing, Xiaoli Zhu","doi":"10.3760/CMA.J.ISSN.1008-1372.2020.01.019","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1008-1372.2020.01.019","url":null,"abstract":"Objective \u0000To explore the value of B-type natriuretic peptide (BNP) be used as a prognostic factor for community-acquired pneumonia. \u0000 \u0000 \u0000Methods \u0000This was a multicenter, retrospective study. Data of patients hospitalized with community-acquired pneumonia during 2014/1/1 to 2015/12/31 from four tertiary hospitals were reviewed, including demographic and clinical features, and outcomes. Univariate analysis and logistic regression analysis were performed to determine risk factors for 30-day mortality. Receiver operating characteristic curves (ROCs) was performed to verify the accuracy of BNP>1 000 pg/ml, CURB-65 score and BNP>1 000 pg/ml+ CURB-65 score (B-CURB65) as 30-day mortality predictors in the study patients. \u0000 \u0000 \u0000Results \u00001 786 patients hospitalized with community-acquired pneumonia (CAP) were entered into the final analysis. The 30-day mortality was 4.7%. Logistic regression analysis confirmed blood BNP>1 000 pg/ml was an independent risk factor associated with 30-day mortality of CAP patients. The area under the curve (AUC) of B-CURB65 was 0.774, which was higher than CURB-65 score (AUC=0.625, P=0.002). \u0000 \u0000 \u0000Conclusions \u0000Blood BNP is a valuable biomarker related to the 30-day mortality of CAP patients, which can increase the predicting accuracy of CURB-65 score. \u0000 \u0000 \u0000Key words: \u0000Natriuretic peptide, brain; Community-acquired pneumonia; Mortality","PeriodicalId":15276,"journal":{"name":"中国医师杂志","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74620437","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Objective To detect the diffusional kurtosis imaging (DKI) parameters of patients with Alzheimer's disease (AD), and evaluate the inner link of DKI parameters with cognitive function and serum nerve injury index. Methods 78 patients who were first diagnosed with AD in our hospital between December 2015 and January 2018 were enrolled in AD group, and 50 healthy volunteers who had physical examination in our hospital during the same period were enrolled in normal control group. The corpus callosum DKI parameters [mean kurtosis (MK), axial kurtosis (AK) and radial kurtosis (RK)] values, Mini-Mental State Examination (MMSE) score as well as serum nerve damage indexes [β amyloid 1-42 (Aβ1-422), S100B protein (S100B) and brain-derived neurotrophic factor (BDNF)] were compared between the two groups of subjects. Pearson test was used to evaluate the correlation of DKI parameters with MMSE score as well as serum nerve injury index in patients with AD. Results MK, AK and RK levels in AD group were lower than those in normal control group; MMSE score was lower than that of normal control group; serum Aβ1-42 and S100B contents were higher than those of normal control group while BDNF content was lower than that of normal control group (P<0.05). Correlation analysis revealed that the MK, AK and RK values in AD patients were directly correlated with the MMSE score as well as Aβ1-42, S100B and BDNF levels (P<0.05). Conclusions The corpus callosum DKI parameter levels decrease in AD patients, and the specific levels are closely related to the severity of cognitive function and nerve injury, which may be one of the effective methods for early assessment of AD condition. Key words: Alzheimer disease; Corpus callosum; Diffusion magnetic resonance imaging; Cognition; Cytokines
{"title":"The correlation of diffusional kurtosis imaging parameters with cognitive function and cytokine secretion in patients with Alzheimer's disease","authors":"Jianghong Liu, Jihong Zhang, Yi-Min Zhai, Li Wang, Lichun Zhang, Lehong Gao","doi":"10.3760/CMA.J.ISSN.1008-1372.2020.01.009","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1008-1372.2020.01.009","url":null,"abstract":"Objective \u0000To detect the diffusional kurtosis imaging (DKI) parameters of patients with Alzheimer's disease (AD), and evaluate the inner link of DKI parameters with cognitive function and serum nerve injury index. \u0000 \u0000 \u0000Methods \u000078 patients who were first diagnosed with AD in our hospital between December 2015 and January 2018 were enrolled in AD group, and 50 healthy volunteers who had physical examination in our hospital during the same period were enrolled in normal control group. The corpus callosum DKI parameters [mean kurtosis (MK), axial kurtosis (AK) and radial kurtosis (RK)] values, Mini-Mental State Examination (MMSE) score as well as serum nerve damage indexes [β amyloid 1-42 (Aβ1-422), S100B protein (S100B) and brain-derived neurotrophic factor (BDNF)] were compared between the two groups of subjects. Pearson test was used to evaluate the correlation of DKI parameters with MMSE score as well as serum nerve injury index in patients with AD. \u0000 \u0000 \u0000Results \u0000MK, AK and RK levels in AD group were lower than those in normal control group; MMSE score was lower than that of normal control group; serum Aβ1-42 and S100B contents were higher than those of normal control group while BDNF content was lower than that of normal control group (P<0.05). Correlation analysis revealed that the MK, AK and RK values in AD patients were directly correlated with the MMSE score as well as Aβ1-42, S100B and BDNF levels (P<0.05). \u0000 \u0000 \u0000Conclusions \u0000The corpus callosum DKI parameter levels decrease in AD patients, and the specific levels are closely related to the severity of cognitive function and nerve injury, which may be one of the effective methods for early assessment of AD condition. \u0000 \u0000 \u0000Key words: \u0000Alzheimer disease; Corpus callosum; Diffusion magnetic resonance imaging; Cognition; Cytokines","PeriodicalId":15276,"journal":{"name":"中国医师杂志","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73917111","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-01-20DOI: 10.3760/CMA.J.ISSN.1008-1372.2020.01.021
Lan Ma
Objective To investigate the influence of metformin on glycolipid metabolism and sex hormone in patients with polycystic ovarian syndrome (PCOS). Methods 98 patients with PCOS were randomly divided into two groups, with 49 cases in each group. The control group were treated with clomifene, while the observation group were treated with clomifene combined metformin. The endometrial thickness and ovarian volume were observed in two groups before and after treatment. The changes of glycolipid metabolism and sex hormone indexes in two groups were analyzed before and after treatment. Results The endometrial thickness of observation group was significantly better than control group after treatment, while the sex hormone levels, ovarian volume and antral follicle count (AFC) were lower than control group (P<0.05). The glycolipid metabolism indexes of total cholesterol (TC), triacylglycerol (TG), fasting blood glucose (FBG), fasting insulin (FIN) and homeostasis model assessment-insulin resistance (HOMA-IR) in observation group were significantly better than control group after treatment (P<0.05). The rate of ovulation and pregnancy in observation group was significantly higher than control group after treatment (P<0.05). Conclusions Clomifene combined metformin can significantly improve glycolipid metabolism and sex hormone of patients with PCOS. It is helpful in promoting ovulation and improving clinical pregnancy rate. Key words: Metformin; Polycystic ovary syndrome; Glucose metabolism; Lipid metabolism; Gonadal hormones
{"title":"Influence of metformin on glycolipid metabolism in patients with polycystic ovarian syndrome","authors":"Lan Ma","doi":"10.3760/CMA.J.ISSN.1008-1372.2020.01.021","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1008-1372.2020.01.021","url":null,"abstract":"Objective \u0000To investigate the influence of metformin on glycolipid metabolism and sex hormone in patients with polycystic ovarian syndrome (PCOS). \u0000 \u0000 \u0000Methods \u000098 patients with PCOS were randomly divided into two groups, with 49 cases in each group. The control group were treated with clomifene, while the observation group were treated with clomifene combined metformin. The endometrial thickness and ovarian volume were observed in two groups before and after treatment. The changes of glycolipid metabolism and sex hormone indexes in two groups were analyzed before and after treatment. \u0000 \u0000 \u0000Results \u0000The endometrial thickness of observation group was significantly better than control group after treatment, while the sex hormone levels, ovarian volume and antral follicle count (AFC) were lower than control group (P<0.05). The glycolipid metabolism indexes of total cholesterol (TC), triacylglycerol (TG), fasting blood glucose (FBG), fasting insulin (FIN) and homeostasis model assessment-insulin resistance (HOMA-IR) in observation group were significantly better than control group after treatment (P<0.05). The rate of ovulation and pregnancy in observation group was significantly higher than control group after treatment (P<0.05). \u0000 \u0000 \u0000Conclusions \u0000Clomifene combined metformin can significantly improve glycolipid metabolism and sex hormone of patients with PCOS. It is helpful in promoting ovulation and improving clinical pregnancy rate. \u0000 \u0000 \u0000Key words: \u0000Metformin; Polycystic ovary syndrome; Glucose metabolism; Lipid metabolism; Gonadal hormones","PeriodicalId":15276,"journal":{"name":"中国医师杂志","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86721124","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-01-20DOI: 10.3760/CMA.J.ISSN.1008-1372.2020.01.022
Ning-jing Yang
Objective To study the effects of single photon emission computed tomography/computed tomography (SPECT/CT) and magnetic resonance imaging (MRI) in the diagnosis of primary bone tumors. Methods A total of 104 patients with primary bone tumors in Zibo Central Hospital hospital from January 2016 to January 2018 were enrolled in this study. SPECT/CT and MRI examinations were performed on these patients, and the results of the examinations were compared with the results of surgical pathology. The diagnostic efficacy of the two methods for primary bone tumors were compared. Results ⑴Results of pathological examination: 70 cases were malignant tumors, and 34 cases were benign tumors; results of SPECT/CT: 72 cases were malignant tumors, and 32 cases were benign tumors; MRI: 76 cases were malignant tumors, and 28 cases were benign tumors; there was no difference between the two methods in the diagnosis of primary bone tumors. ⑵ The sensitivity, specificity, accuracy, positive predictive value and negative predictive value of SPECT/CT were 92.86%, 79.41%, 88.46%, 90.28% and 84.38% respectively, slightly higher than those of MRI (91.43%, 64.71%, 82.69%, 84.21% and 78.57%), but the difference was not statistically significant (P>0.05). ⑶ There was a high consistency between SPECT/CT and MRI in the diagnosis of primary bone tumors (Kappa value=0.613). ⑷ SPECT/CT is more accurate in the diagnosis of osteosarcoma, giant cell tumor, myeloma and fibrous dysplasia, while MRI is more accurate in the diagnosis of osteosarcoma, chordoma, Ewing's sarcoma and schwannoma. Conclusions SPECT/CT fusion imaging and MRI have high sensitivity and accuracy in the diagnosis of primary bone tumors, and the results of the two diagnostic methods have high consistency. SPECT/CT has a high accuracy in the diagnosis of ossification and calcification, while MRI has a high accuracy in the diagnosis of bone tumors in bone soft tissue and nervous system. Therefore, the joint application of the two methods can make up for each other's shortcomings and make the diagnosis of primary bone tumor more accurate. Key words: Tomography, emission-computed, single-photon; Magnetic resonance imaging; Bone neoplasms
{"title":"Diagnostic value of SPECT/CT tomographic fusion imaging and magnetic resonance imaging in primary bone tumors","authors":"Ning-jing Yang","doi":"10.3760/CMA.J.ISSN.1008-1372.2020.01.022","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1008-1372.2020.01.022","url":null,"abstract":"Objective \u0000To study the effects of single photon emission computed tomography/computed tomography (SPECT/CT) and magnetic resonance imaging (MRI) in the diagnosis of primary bone tumors. \u0000 \u0000 \u0000Methods \u0000A total of 104 patients with primary bone tumors in Zibo Central Hospital hospital from January 2016 to January 2018 were enrolled in this study. SPECT/CT and MRI examinations were performed on these patients, and the results of the examinations were compared with the results of surgical pathology. The diagnostic efficacy of the two methods for primary bone tumors were compared. \u0000 \u0000 \u0000Results \u0000⑴Results of pathological examination: 70 cases were malignant tumors, and 34 cases were benign tumors; results of SPECT/CT: 72 cases were malignant tumors, and 32 cases were benign tumors; MRI: 76 cases were malignant tumors, and 28 cases were benign tumors; there was no difference between the two methods in the diagnosis of primary bone tumors. ⑵ The sensitivity, specificity, accuracy, positive predictive value and negative predictive value of SPECT/CT were 92.86%, 79.41%, 88.46%, 90.28% and 84.38% respectively, slightly higher than those of MRI (91.43%, 64.71%, 82.69%, 84.21% and 78.57%), but the difference was not statistically significant (P>0.05). ⑶ There was a high consistency between SPECT/CT and MRI in the diagnosis of primary bone tumors (Kappa value=0.613). ⑷ SPECT/CT is more accurate in the diagnosis of osteosarcoma, giant cell tumor, myeloma and fibrous dysplasia, while MRI is more accurate in the diagnosis of osteosarcoma, chordoma, Ewing's sarcoma and schwannoma. \u0000 \u0000 \u0000Conclusions \u0000SPECT/CT fusion imaging and MRI have high sensitivity and accuracy in the diagnosis of primary bone tumors, and the results of the two diagnostic methods have high consistency. SPECT/CT has a high accuracy in the diagnosis of ossification and calcification, while MRI has a high accuracy in the diagnosis of bone tumors in bone soft tissue and nervous system. Therefore, the joint application of the two methods can make up for each other's shortcomings and make the diagnosis of primary bone tumor more accurate. \u0000 \u0000 \u0000Key words: \u0000Tomography, emission-computed, single-photon; Magnetic resonance imaging; Bone neoplasms","PeriodicalId":15276,"journal":{"name":"中国医师杂志","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86290022","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Objective To improve the awareness of emergency biliary obstruction (BO) disease, and to further improve the diagnosis and treatment ability of BO patients. Methods Data of the etiology, clinical manifestations, imaging data, laboratory tests, and emergency treatment outcomes in 63 BO patients were retrospectively analyzed. Results Common bile duct stones were the most common cause of BO patients (63.49%), followed by cholangiocarcinoma (19.05%); the most common clinical manifestations of BO patients were jaundice (90.48%), abdominal pain (87.30%), and fever (53.97%); the diagnostic ability of computed tomography (CT) and magnetic resonance cholangiopancreatography (MRCP) in patients with BO was significantly higher than that of ultrasound (P<0.05), but there was no significant difference between CT and MRCP (P=1.000); compared with benign group, hemoglobin and albumin in malignant group were significantly lower, while total bilirubin and direct bilirubin were higher, with statistically significant difference (P<0.05). Most patients in BO patients improved after treatment, and the mortality rate of BO patients was 3.17%(2/63) at the end of emergency visit. Conclusions Common bile duct stones and cholangiocarcinoma are still the most common causes of emergency BO patients. The most common clinical manifestations of patients with emergency BO are jaundice, abdominal pain, and fever. Better than abdominal ultrasound, CT and MRCP have comparable diagnostic capabilities in the diagnosis of emergency BO patients. Anemia, hyperbilirubinemia and hypoproteinemia are alarm indicators for malignant tumors in emergency BO patients. Most patients can temporarily get better at the end of emergency visit. Key words: Choledocholithiasis; Bile duct neoplasms; Biliary obstruction; Cholangiopancreatography, magnetic resonance; Emergency treatment; Biliary tract surgery procedures
{"title":"Analysis of clinical diagnosis and treatment in 63 patients with emergency biliary obstruction","authors":"Hongtao Wei, Tianpeng Zhang, Bing Liu, Jian-dong Zhang","doi":"10.3760/CMA.J.ISSN.1008-1372.2020.01.003","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1008-1372.2020.01.003","url":null,"abstract":"Objective \u0000To improve the awareness of emergency biliary obstruction (BO) disease, and to further improve the diagnosis and treatment ability of BO patients. \u0000 \u0000 \u0000Methods \u0000Data of the etiology, clinical manifestations, imaging data, laboratory tests, and emergency treatment outcomes in 63 BO patients were retrospectively analyzed. \u0000 \u0000 \u0000Results \u0000Common bile duct stones were the most common cause of BO patients (63.49%), followed by cholangiocarcinoma (19.05%); the most common clinical manifestations of BO patients were jaundice (90.48%), abdominal pain (87.30%), and fever (53.97%); the diagnostic ability of computed tomography (CT) and magnetic resonance cholangiopancreatography (MRCP) in patients with BO was significantly higher than that of ultrasound (P<0.05), but there was no significant difference between CT and MRCP (P=1.000); compared with benign group, hemoglobin and albumin in malignant group were significantly lower, while total bilirubin and direct bilirubin were higher, with statistically significant difference (P<0.05). Most patients in BO patients improved after treatment, and the mortality rate of BO patients was 3.17%(2/63) at the end of emergency visit. \u0000 \u0000 \u0000Conclusions \u0000Common bile duct stones and cholangiocarcinoma are still the most common causes of emergency BO patients. The most common clinical manifestations of patients with emergency BO are jaundice, abdominal pain, and fever. Better than abdominal ultrasound, CT and MRCP have comparable diagnostic capabilities in the diagnosis of emergency BO patients. Anemia, hyperbilirubinemia and hypoproteinemia are alarm indicators for malignant tumors in emergency BO patients. Most patients can temporarily get better at the end of emergency visit. \u0000 \u0000 \u0000Key words: \u0000Choledocholithiasis; Bile duct neoplasms; Biliary obstruction; Cholangiopancreatography, magnetic resonance; Emergency treatment; Biliary tract surgery procedures","PeriodicalId":15276,"journal":{"name":"中国医师杂志","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85022922","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-01-20DOI: 10.3760/CMA.J.ISSN.1008-1372.2020.01.006
Zhaoqing Lu, Guoxing Wang
Acute cholangitis (AC) is a morbid condition with acute inflammation and infection in the bile duct, which meets the diagnostic criteria of sepsis 3.0. AC mortality rate is high without treatment in time, and it is a main disease in emergency department. The occurrence and development of sepsis depend on the regulation of nerve and immunity system, and cholinergic anti-inflammatory pathway plays an important role in connecting nerve and immune function. The biliary tract is innervated by vagus nerves, which can be excited when the pressure increases in the biliary tract. The research on the role of vagus nerves and cholinergic anti-inflammatory pathway (CAIP) in sepsis caused by acute cholangitis is more advantageous than other infectious diseases. Key words: Vagus nerve; Acute cholangitis; Sepsis
{"title":"The role of vagus nerve in sepsis induced by acute cholangitis and its possible mechanism","authors":"Zhaoqing Lu, Guoxing Wang","doi":"10.3760/CMA.J.ISSN.1008-1372.2020.01.006","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1008-1372.2020.01.006","url":null,"abstract":"Acute cholangitis (AC) is a morbid condition with acute inflammation and infection in the bile duct, which meets the diagnostic criteria of sepsis 3.0. AC mortality rate is high without treatment in time, and it is a main disease in emergency department. The occurrence and development of sepsis depend on the regulation of nerve and immunity system, and cholinergic anti-inflammatory pathway plays an important role in connecting nerve and immune function. The biliary tract is innervated by vagus nerves, which can be excited when the pressure increases in the biliary tract. The research on the role of vagus nerves and cholinergic anti-inflammatory pathway (CAIP) in sepsis caused by acute cholangitis is more advantageous than other infectious diseases. \u0000 \u0000 \u0000Key words: \u0000Vagus nerve; Acute cholangitis; Sepsis","PeriodicalId":15276,"journal":{"name":"中国医师杂志","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75518602","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-01-20DOI: 10.3760/CMA.J.ISSN.1008-1372.2020.01.001
Hongli Xiao
Digestive tract is one of the biggest contact surfaces between human body and environmental factors. It has a large number of microorganisms from the environment. Once bacteria transfer and release into the blood, it will cause sepsis and endanger life. Therefore, we should pay more attention to the infectious diseases of digestive system. This paper reviews six articles published in this journal, and expounds the etiology and early recognition methods of severity of three common infectious diseases of acute digestive system, namely, acute diarrhea, acute cholangitis and acute pancreatitis, and puts forward potential targets for the treatment of sepsis from the perspective of neurohumoral and integrated traditional Chinese and western medicine. Therefore, we should pay attention to the early recognition of the severity of infectious diseases of digestive system and the treatment of integrated traditional Chinese and western medicine. Key words: Digestive system; Infection; Severity of illness; Early diagnosis; TCM WM THERAPY
{"title":"Pay attention to the early recognition of severe digestive system infection and the treatment of integrated traditional Chinese and western medicine","authors":"Hongli Xiao","doi":"10.3760/CMA.J.ISSN.1008-1372.2020.01.001","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1008-1372.2020.01.001","url":null,"abstract":"Digestive tract is one of the biggest contact surfaces between human body and environmental factors. It has a large number of microorganisms from the environment. Once bacteria transfer and release into the blood, it will cause sepsis and endanger life. Therefore, we should pay more attention to the infectious diseases of digestive system. This paper reviews six articles published in this journal, and expounds the etiology and early recognition methods of severity of three common infectious diseases of acute digestive system, namely, acute diarrhea, acute cholangitis and acute pancreatitis, and puts forward potential targets for the treatment of sepsis from the perspective of neurohumoral and integrated traditional Chinese and western medicine. Therefore, we should pay attention to the early recognition of the severity of infectious diseases of digestive system and the treatment of integrated traditional Chinese and western medicine. \u0000 \u0000 \u0000Key words: \u0000Digestive system; Infection; Severity of illness; Early diagnosis; TCM WM THERAPY","PeriodicalId":15276,"journal":{"name":"中国医师杂志","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80096393","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-01-20DOI: 10.3760/CMA.J.ISSN.1008-1372.2020.01.023
Xiaoqian Tan, H. Mei, Kun Liu, Jin Tang, Jiang-yan Wu, G. Zhu
Objective To detect the expression of miR-373 in osteosarcoma cells and explore its effects on cell proliferation, invasion, and migration. Methods Human osteosarcoma cell line SJSA-1 and human osteoblast hFOB 1.19 cultured in vitro. Human osteosarcoma cell line SJSA-1 were randomly divided into four groups: blank control group (CK group), negative control group (NC group), miR-373 over-expressed plasmid group (miR-373 mimic group) and miR-373 inhibited plasmid group (miR-373 inhibitor group). Cells were transfected with FuGENE® HD transfection reagent. After 48 hours of transfection, the relative expression of miR-373 was detected by quantitative real-time polymerase chain reaction (qRT-PCR), cell proliferation by cell counting kit-8 (CCK-8) and cell invasion and migration by Transwell. Results The relative expression of miR-373 in SJSA-1 cells was significantly higher than that in hFOB-1.19 cells (P<0.05); compared with CK group and NC group, the relative expression of miR-373 in the miR-373 mimic group increased significantly (P<0.05), and the relative expression of miR-373 in the miR-373 inhibitor group was significantly lower than that in the control group (P<0.05); optical density (OD) value of miR-373 mimic group at 24 h, 36 h, and 48 h were significantly higher than that of CK group and NC group (P<0.05), and OD value of miR-373 inhibitor group at 24 h, 36 h, and 48 h were significantly lower than that of CK group and NC group (P<0.05); the number of cell migration in the miR-373 mimic group was significantly higher than that in the CK group and NC group (P<0.05), and the number of cell migration in the miR-373 inhibitor group was significantly lower than that in CK group and NC group (P<0.05); the number of cell migration in the miR-373 mimic group was significantly higher than that in the CK group and NC group (P<0.05), and the number of cell migration in the miR-373 inhibitor group was significantly lower than that in CK group and NC group (P<0.05). Conclusions The expression of miR-373 is up-regulated in osteosarcoma. Overexpression of miR-373 can promote the proliferation, invasion, and migration of osteosarcoma cells, while the low expression of miR-373 can inhibit the proliferation, invasion, and migration of osteosarcoma cells, which may be an important target for the diagnosis and treatment of osteosarcoma. Key words: Osteosarcoma; Cell line, tumor; miR-373; Cell proliferation; Cell invasion; Cell migration
{"title":"Effects of miR-373 on proliferation, invasion and migration of osteosarcoma cells","authors":"Xiaoqian Tan, H. Mei, Kun Liu, Jin Tang, Jiang-yan Wu, G. Zhu","doi":"10.3760/CMA.J.ISSN.1008-1372.2020.01.023","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1008-1372.2020.01.023","url":null,"abstract":"Objective \u0000To detect the expression of miR-373 in osteosarcoma cells and explore its effects on cell proliferation, invasion, and migration. \u0000 \u0000 \u0000Methods \u0000Human osteosarcoma cell line SJSA-1 and human osteoblast hFOB 1.19 cultured in vitro. Human osteosarcoma cell line SJSA-1 were randomly divided into four groups: blank control group (CK group), negative control group (NC group), miR-373 over-expressed plasmid group (miR-373 mimic group) and miR-373 inhibited plasmid group (miR-373 inhibitor group). Cells were transfected with FuGENE® HD transfection reagent. After 48 hours of transfection, the relative expression of miR-373 was detected by quantitative real-time polymerase chain reaction (qRT-PCR), cell proliferation by cell counting kit-8 (CCK-8) and cell invasion and migration by Transwell. \u0000 \u0000 \u0000Results \u0000The relative expression of miR-373 in SJSA-1 cells was significantly higher than that in hFOB-1.19 cells (P<0.05); compared with CK group and NC group, the relative expression of miR-373 in the miR-373 mimic group increased significantly (P<0.05), and the relative expression of miR-373 in the miR-373 inhibitor group was significantly lower than that in the control group (P<0.05); optical density (OD) value of miR-373 mimic group at 24 h, 36 h, and 48 h were significantly higher than that of CK group and NC group (P<0.05), and OD value of miR-373 inhibitor group at 24 h, 36 h, and 48 h were significantly lower than that of CK group and NC group (P<0.05); the number of cell migration in the miR-373 mimic group was significantly higher than that in the CK group and NC group (P<0.05), and the number of cell migration in the miR-373 inhibitor group was significantly lower than that in CK group and NC group (P<0.05); the number of cell migration in the miR-373 mimic group was significantly higher than that in the CK group and NC group (P<0.05), and the number of cell migration in the miR-373 inhibitor group was significantly lower than that in CK group and NC group (P<0.05). \u0000 \u0000 \u0000Conclusions \u0000The expression of miR-373 is up-regulated in osteosarcoma. Overexpression of miR-373 can promote the proliferation, invasion, and migration of osteosarcoma cells, while the low expression of miR-373 can inhibit the proliferation, invasion, and migration of osteosarcoma cells, which may be an important target for the diagnosis and treatment of osteosarcoma. \u0000 \u0000 \u0000Key words: \u0000Osteosarcoma; Cell line, tumor; miR-373; Cell proliferation; Cell invasion; Cell migration","PeriodicalId":15276,"journal":{"name":"中国医师杂志","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88024955","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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