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Simulation and biomechanical evaluation of unpowered knee assisted exoskeleton 无动力膝关节辅助外骨骼的模拟与生物力学评价
Xinyao Tang, Xupeng Wang, Yawen Zhou
In order to evaluate the effectiveness of exoskeleton design, a detailed evaluation of human biomechanics is necessary. In this paper, an unpowered exoskeleton of the knee joint is designed. A simplified 5-bar model of the lower limb is used to establish a walking kinematics model, and the change equation of knee angle is obtained. The curve of the knee angle is obtained through Matlab simulation and Visual 3D software. The simulation results are similar to the experiment, and the change curve of knee angle is consistent with the test results of human walking. It shows that the simplified model and simulation test is reasonable and effective, and conform to the walking process of human lower limbs. The activation and metabolism of lower limb muscles in three wearing states were obtained by using the OpenSim software, and the muscle activation was compared with the EMG test. The experimental results show that the exoskeletons in the gait cycle have different effects on the muscles of the lower limbs. The exoskeletons can provide assisted force for walking, reducing muscle activity and metabolic rate.
为了评估外骨骼设计的有效性,有必要对人体生物力学进行详细的评估。本文设计了一种无动力的膝关节外骨骼。采用简化的下肢五杆模型建立了行走运动学模型,得到了膝关节角度的变化方程。通过Matlab仿真和Visual 3D软件得到膝关节角度曲线。仿真结果与实验结果相似,膝关节角度变化曲线与人体行走试验结果一致。结果表明,该简化模型和仿真试验合理有效,符合人体下肢行走过程。利用OpenSim软件获取三种佩戴状态下下肢肌肉的激活和代谢情况,并与肌电图进行对比。实验结果表明,步态周期中的外骨骼对下肢肌肉有不同程度的影响。外骨骼可以为行走提供辅助力量,减少肌肉活动和代谢率。
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引用次数: 0
Application of artificial intelligence in mental health and mental illnesses 人工智能在心理健康和精神疾病中的应用
Xishuang Feng, Maorong Hu, Wanhui Guo
Purpose of review: Artificial intelligence (AI), a hot area of research today, has been attempted to be applied in various fields of clinical medicine. This paper reviews the current status of research on AI in mental health and mental illness, including applications in the prevention, supplementary diagnosis, treatment and rehabilitation of mental illness. It also discusses the advantages, shortcomings and prospects of AI applications in the field of mental disorders, in order to provide references for research related to mental health applications based on AI technology. Research methods: The literature on the application of AI in mental illness interventions in recent years was searched through literature navigation. The aspects of mental illness prevention, diagnosis and treatment interventions were analyzed. Research conclusion: AI technology is developing rapidly and can complement the advantages of artificial diagnosis and treatment. However, AI still has a lot of room for development and has shortcomings at this stage that may bring some problems, such as algorithm bias, ethical aspects and difficulty in promotion at this stage. As mental health practitioners, we should actively adapt to and promote the further development of AI in the mental health field.
综述目的:人工智能(AI)是当今的一个研究热点,已被尝试应用于临床医学的各个领域。本文综述了人工智能在精神卫生和精神疾病领域的研究现状,包括在精神疾病的预防、辅助诊断、治疗和康复等方面的应用。探讨了人工智能在精神障碍领域应用的优势、不足及前景,以期为基于人工智能技术的精神健康应用相关研究提供参考。研究方法:通过文献导航检索近年来有关人工智能在精神疾病干预中的应用的文献。分析了精神疾病的预防、诊断和治疗干预措施。研究结论:人工智能技术发展迅速,可以补充人工诊疗的优势。但是,人工智能在现阶段还有很大的发展空间,也存在一些不足,可能会带来一些问题,比如算法偏差、伦理方面、推广难度等。作为心理健康从业者,我们应该积极适应和推动人工智能在心理健康领域的进一步发展。
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引用次数: 0
Identification of Cardiovascular Diseases Based on Machine Learning 基于机器学习的心血管疾病识别
Yubin Wang
Cardiovascular disease has been a major killer threatening human life and health. This paper is devoted to studying the characteristics of patients with cardiovascular diseases and classifying them by physical examination indicators. K-means algorithm is uesd to analyze the characteristics and xgboost is used to form a better classifier. The effect of the models are evaluated by relevant indexes. The experimental results show that, compared with normal people, patients with cardiovascular diseases have three characteristics: an older age, higher blood pressure, and heavier weight. Meanwhile, systolic blood pressure, cholesterol, and age are three important indicators for the classification of cardiovascular diseases.
心血管疾病已成为威胁人类生命和健康的主要杀手。本文致力于研究心血管疾病患者的特点,并通过体检指标对其进行分类。使用K-means算法分析特征,使用xgboost形成更好的分类器。通过相关指标对模型的效果进行了评价。实验结果表明,与正常人相比,心血管疾病患者具有年龄较大、血压较高、体重较重三个特点。同时,收缩压、胆固醇、年龄是心血管疾病分类的三个重要指标。
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引用次数: 1
Data Mining-Based Analysis of Chinese Medicinal Herb Formulae in Metabolic associated fatty liver Disease Treatment 基于数据挖掘的中药方剂治疗代谢性脂肪肝的研究
Jixian Zheng, Sufei Song, Anni Zheng, Cui Cong, T. Sun, Qiu-ling Xu, Tao Liu
Introduction: Metabolism-associated lipid disorders (MAFLD) are the most common form of liver disease. Traditional Chinese medicine (TCM) has obvious efficacy in the treatment of MAFLD, but its therapeutic mechanism is unclear. The dosage regimen and potential mechanism of action of TCM for the treatment of MAFLD can be investigated using data mining methods. Methods: The literature related to TCM for the treatment of MAFLD in China Knowledge Network (CNKI), WANFANG Data and PUBMED in the last ten years were searched. The the frequency of drug use and its efficacy, flavour, and attribution were counted, and an analysis of high-frequency drug associations, cluster analysis, and factor analysis were conducted, respectively. Results: The top 6 single herbs of frequency are Poria, Licorice, Atractylodes Macrocephala, Bupleurum, Alisma, and Dried Tangerine Peel; the top 3 in frequency are tonic drugs, diuretic and dampening drugs, and blood stasis-activating drugs. The correlation analysis produced 4 association rules for drug combinations, 30 association rules for the three-flavour group and 18 association rules for the four-flavour group, which are related to Sijunzi Decoction, Erchen Decoction, Chaihu Shugan Powder. Hierarchical cluster analysis divides TCM into 5 categories, which are related to Taohong Siwu Decoction, Gegen Qinlian Decoction, Sini Powder, etc. The 8 drug groups obtained from the factor analysis reflect the treatment methods of strengthening spleen and soothing liver, eliminating dampness, and eliminating phlegm. Conclusion: Chinese drugs with the effects of strengthening the spleen, soothing the liver, dissipating humidity, toning the blood and lowering lipids, play a major role in the treatment of MAFLD.
代谢相关脂质紊乱(MAFLD)是最常见的肝脏疾病。中药治疗mald疗效明显,但其治疗机制尚不清楚。利用数据挖掘方法可以研究中药治疗MAFLD的给药方案和潜在的作用机制。方法:检索中国知网(CNKI)、万方数据(WANFANG Data)和PUBMED近十年来有关mld中医治疗的相关文献。统计用药频次、药效、风味、归因,分别进行高频药物关联分析、聚类分析和因子分析。结果:单药频率前6位依次为茯苓、甘草、苍术、柴胡、泽泻、陈皮;使用频率前3位依次为滋补药、利尿湿药和活血化瘀药。相关性分析得到4条药物组合关联规则,3味组关联规则30条,4味组关联规则18条,与四君子汤、二臣汤、柴胡疏肝散相关。层次聚类分析将中药分为5类,分别与桃红四物汤、葛根芩连汤、四逆散等相关。因子分析得到的8个药物组体现了健脾疏肝、祛湿化痰的治疗方法。结论:具有健脾、疏肝、散湿、补血、降脂作用的中药在治疗mald中起主要作用。
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引用次数: 0
Silencing BAG3 Inhibits Tumor Cell Proliferation by reducing the Activation of ERK in TNBC 沉默BAG3通过降低TNBC中ERK的激活抑制肿瘤细胞增殖
Zeqian Li
Triple-negative breast cancer has high reoccurrence rates after chemotherapy treatment. This kind of cancer easily transfers from its first position to other organs, and the death rates increase a lot during this process. New therapies targeting multiple signaling nodes are being explored nowadays. Previous studies have reported that BAG3 can interact with components of a different signaling pathway to promote tumor cell proliferation. In this paper, we explored whether protein ERK1/2, a component in the EGFR pathway, has a physical interaction with BAG3 and the effect of silencing BAG3 using SiBAG3 on activating ERK1/2 and tumor cell proliferation in vivo conditions. Six possible results are proposed to illustrate the relation between BAG3, ERK, and tumor cell proliferation. The study's results will provide theoretical evidence on whether preventing the interaction between BAG3 and ERK could be a potential treatment method for TNBC.
三阴性乳腺癌化疗后复发率高。这种癌症很容易从最初的位置转移到其他器官,在这个过程中死亡率会增加很多。目前正在探索针对多个信号节点的新疗法。先前的研究报道BAG3可以与不同信号通路的组分相互作用,促进肿瘤细胞增殖。在本文中,我们探讨了EGFR通路中的一个组分ERK1/2蛋白是否与BAG3存在物理相互作用,以及在体内条件下使用SiBAG3沉默BAG3对激活ERK1/2和肿瘤细胞增殖的影响。我们提出了六个可能的结果来说明BAG3、ERK和肿瘤细胞增殖之间的关系。该研究结果将为阻止BAG3和ERK之间的相互作用是否可能成为TNBC的潜在治疗方法提供理论证据。
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引用次数: 0
Multi-omics clustering based on dual contrastive learning for cancer subtype identification 基于双重对比学习的多组学聚类在癌症亚型识别中的应用
Yuxin Chen
Multi-omics clustering aims to supplement a single omics with data information from multiple omics, assigning samples into their respective clusters without supervision. The existing multi-omics clustering methods tend to use the similarity measure function to construct the similarity network between samples, and then fuse the various omics networks together for clustering by some fusion methods. These methods relies heavily on the original features of the data and the similarity measure function. This paper proposes a novel multi-omics clustering method. The proposed model first uses neural networks to extract the feature embeddings of omics, and then aligns the feature embeddings of different omics in subspaces through contrastive learning. Finally, the feature embeddings are mapped to clustered soft labels, and the soft labels are aligned again using contrastive learning. Experiments show that our method outperforms the baseline methods.
多组学聚类旨在用多个组学的数据信息来补充单个组学,在没有监督的情况下将样本分配到各自的聚类中。现有的多组学聚类方法倾向于利用相似性度量函数构建样本间的相似性网络,然后通过一些融合方法将不同的组学网络融合在一起进行聚类。这些方法在很大程度上依赖于数据的原始特征和相似度量函数。提出了一种新的多组学聚类方法。该模型首先利用神经网络提取组学的特征嵌入,然后通过对比学习将不同组学的特征嵌入在子空间中对齐。最后,将特征嵌入映射到聚类软标签,并使用对比学习再次对齐软标签。实验表明,该方法优于基准方法。
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引用次数: 0
Predicting the Future of Achieving Herd Immunity in New York City 预测纽约市实现群体免疫的未来
Qi Zhuo
COVID-19 has a huge impact on the economic and social development of the world. In this paper, a simulation model of virus transmission was developed using the netlogo platform based on the characteristics of humans developing acquired immunity to a virus they once had, and predicted the prospects of achieving herd immunity under two scenarios: no vaccination and vaccination of a certain percentage of the population. The results show that failure to vaccinate leads to a longer duration of the outbreak, as well as an increase in the number of infected individuals and overall mortality. If vaccination is administered, the time to achieve herd immunity will be substantially reduced.
新冠肺炎疫情对世界经济社会发展产生巨大影响。本文基于人类对曾经感染过的病毒产生获得性免疫的特点,利用netlogo平台建立了病毒传播的模拟模型,并预测了不接种疫苗和一定比例人群接种疫苗两种情况下实现群体免疫的前景。结果表明,不接种疫苗会导致疫情持续时间更长,感染人数和总死亡率也会增加。如果接种疫苗,实现群体免疫的时间将大大缩短。
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引用次数: 0
Comparison Between Montelukast Sodium and Tiotropium Bromide for Asthma Treatment 孟鲁司特钠与噻托溴铵治疗哮喘的比较
Chenyi Zhang
Asthma is a common chronic disease that has various causes. Patients feel dyspnea and chest tightness when asthma is an outbreak. The mortality rate is decreasing due to the development of medicine to treat asthma. The primary two drugs are Montelukast sodium and Tiotropium bromide. They have different pH values but similar chemical characteristics, such as charge. These two drugs work similarly as well; both alleviate asthma by blocking specific receptors. They are both orally taken, but Montelukast is made to a tablet, while Tiotropium needs a handihaler to use. This difference creates a price difference.
哮喘是一种常见的慢性疾病,有多种原因。哮喘发作时,患者会感到呼吸困难和胸闷。由于治疗哮喘药物的发展,死亡率正在下降。主要的两种药物是孟鲁司特钠和噻托溴铵。它们的pH值不同,但化学特性相似,比如电荷。这两种药物的作用相似;两者都通过阻断特定受体来缓解哮喘。它们都是口服的,但孟鲁司特是制成片剂的,而噻托溴铵则需要一个手持工具来使用。这种差异造成了价格差异。
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引用次数: 0
Evaluation study on comfort of flexible Knee Joint Protector 柔性膝关节保护器的舒适性评价研究
Jiaxin Zhao, Xupeng Wang
In order to evaluate the comfort of knee joint protector more accurately, the paper proposes a comfort evaluation method, which is based on pressure distribution on type value points of knee joint protector. In this research, a 26-year-old healthy male postgraduate was used as the subject. Firstly, the point cloud data of knee morphology of the subject was obtained by 3D scanning and morphological reconstruction was performed. Secondly, the relationship during knee morphology, protector morphology as well as pressure was established, and the morphological mapping curves of the flexible knee joint protector were constructed. Thirdly, the pressure distribution calculation on the key data points were carried out, and were classified with high, normal and low pressure values. Then, by changing the morphology of knee joint protector, not only is the high value of regional pressure reduced and the comfort improved, but also the low value of regional pressure is increased in order to improve the function of the protector. The research results provide theoretical reference for the study of the comfort of flexible knee joint protector.
为了更准确地评价膝关节保护器的舒适性,提出了一种基于膝关节保护器类型值点压力分布的舒适性评价方法。本研究以一名26岁的健康男性研究生为研究对象。首先,通过三维扫描获取被试膝关节形态的点云数据,并进行形态重建;其次,建立膝关节形态、保护器形态与压力之间的关系,构建柔性膝关节保护器形态映射曲线;第三,对关键数据点进行压力分布计算,并将其分为高压值、正态值和低压值。然后,通过改变膝关节保护器的形态,既减少了高值的区域压力,提高了舒适性,又增加了低值的区域压力,从而提高了保护器的功能。研究结果为柔性膝关节保护器的舒适性研究提供了理论参考。
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引用次数: 0
Research on Prisoner Psychological Symptoms Quick Screening Model Based on Ensemble Learning 基于集成学习的囚犯心理症状快速筛选模型研究
Zhifei Xu, Yan Wang, Bo Jiang
With the rapid development of information technology such as artificial intelligence and big data, the organic combination of these new technologies with traditional psychological research paradigms can effectively improve the research logic, research methods and research tools of traditional psychological measurement, improve the objectivity, accuracy and efficiency of traditional psychological measurement, and thus improve the limitations of traditional psychological evaluation methods. Based on the big data of 25214 community correctional prisoners SCL-90 symptom self-assessment scale samples in a province, this paper first uses the machine learning XGB algorithm to generate the importance ranking of the items (features) of the self-assessment scale, carry out dimension reduction processing and feature selection, and then constructs a fusion algorithm model for classification prediction. This model takes GBDT, RF, AdaBoost as the baseline model, and uses Voting algorithm for fusion processing, In order to avoid the error bias caused by a single model, through performance comparison and analysis, the accuracy of the fusion processing results is the highest, reaching 0.974, and the recall and F1 score are also the highest, reaching 0.90 and 0.92 respectively.
随着人工智能、大数据等信息技术的快速发展,将这些新技术与传统心理学研究范式有机结合,可以有效改进传统心理测量的研究逻辑、研究方法和研究工具,提高传统心理测量的客观性、准确性和效率,从而改善传统心理评价方法的局限性。本文基于某省25214份社区矫正犯SCL-90症状自评量表样本的大数据,首先利用机器学习XGB算法生成自评量表项目(特征)的重要性排序,进行降维处理和特征选择,然后构建融合算法模型进行分类预测。该模型以GBDT、RF、AdaBoost为基准模型,采用Voting算法进行融合处理,为了避免单一模型带来的误差偏差,通过性能对比分析,融合处理结果的准确率最高,达到0.974,召回率和F1得分也最高,分别达到0.90和0.92。
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引用次数: 0
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Proceedings of the 3rd International Symposium on Artificial Intelligence for Medicine Sciences
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