Journal of clinical and experimental neuropsychology最新文献

Introduction: The extent to which different types of attention are affected in RRMS based on disease duration has not been extensively analyzed. Therefore, the aim of this study was to determine whether MS patients differ compared to healthy individuals in a homogeneous sample of RRMS patients in terms of attention types and from which year of MS attention deficit starts. Another aim of the study was to examine the effect of MS duration and stimulus onset asynchrony on dual task performance.

Methods: The sample consisted of RRMS patients (n = 53) and healthy participants (n = 30) between the ages of 20-49, who were at least primary school graduates. Healthy participants in the comparison group were reached by snowball sampling technique. Stroop Test, Cancellation Test, Paced Auditory Serial Addition Test, Coding Test, WMS-R Digit Span and Visual Memory Span subtests were administered to assess attention. Divided attention performance was assessed with a dual task developed based on psychological refractory period paradigm.

Results: The results show that there is a significant difference between RRMS patients and healthy participants in terms of different types of attention (p < 0.05). Focused, sustained and divided attention of RRMS patients and the ability to resist interference showed a significant decline from the 7th year of the disease (p < 0.05); no significant difference was found between healthy participants and patients with 1-6 years of RRMS.

Conclusions: Although the results of the study are consistent with the literature which show that attention deficit develops in MS, it is important in terms of showing that attention deficit changes depending on the duration of the disease. Focused attention, sustained attention, interference resistance and divided attention performance of RRMS patients showed a significant decline after the 7th year of the disease.

Background: Performance validity (PV) and symptom validity (SV) tests assess biased responding that impact scores on neuropsychological tests. The extent to which PV and SV represent overlapping or unique constructs remains incompletely defined, especially among psychiatric patients in a non-forensic setting. The current study investigated this question using confirmatory factor analysis.

Method: Eighty-two inpatients with mood disorders were administered the Word Memory Test, and its primary indices formed a latent variable of PV. From the Minnesota Multiphasic Personality Inventory-2 the Fake Bad Scale (FBS), Response Bias Scale (RBS), and Henry-Heilbronner Index (HHI) were employed as a latent SV variable. Two models of the relationship between PV and SV were compared. One freely estimated the shared variance between SV and PV latent constructs. The other assumed the relationship between SV and PV was homogeneous, and covariance was fixed to 1.0.

Results: In the freely estimated model, covariance between PV and SV was -0.18, and model fit was excellent (CFI = 0.098; TLI = 0.096; SRMR = 0.08). For the fixed model, the RBS, HHI, and FBS achieved low loadings on the SV construct, and model fit was poor (CFI = 0.66; TLI = 0.43; SRMR = 0.42).

Conclusions: PV as indexed by the WMT and SV measured by the MMPI-2 are not overlapping constructs among inpatients with mood disorders. These data imply that PV and SV represent distinct constructs in this population. Implications for practice are discussed.

Introduction: We investigated the roles of group ethnicity and display rules of emotions in the neuropsychology of social cognition in Asian American and White participants recruited from a majority-minority college campus.

Method: 128 participants (mean age = 24.9 years) completed: 1) Advanced Clinical Solutions-Social Perception (ACS-SP), which includes separate measures of affect naming of facial expressions and emotional prosody interpretation of audio statements; 2) Display Rule Assessment Inventory (DRAI), a self-report measure of emotional expressivity across four settings (family, close friends, colleagues, and strangers) and in two distinct domains (should/actual) that asks participants what they believe people should do (social value) and what they would actually do (behavioral self-report).

Results: ACS-SP revealed evidence of cultural bias, as reflected by group ethnicity differences, for recognition of emotional prosody but not emotional facial expressions for Asian American versus White participants. The DRAI showed significant cultural differences only for family relationships with White participants endorsing stronger belief in the social value of expressing negative emotions of sadness, aversion, and fear. These AC-SP and DRAI group differences remained significant when covarying for spoken English language, as measured by an oral word reading test. Hierarchical regression results indicated that group ethnicity and family display rules each made specific and significant contributions to neuropsychological performance but did so in very different and distinct ways. Group ethnicity exerted its greatest effect on prosody interpretation whereas family display rules had its most pronounced influence on affect naming.

Conclusions: The current results may help inform and advance culturally responsive neuropsychological models of social cognition.

Non-neurological factors such as the "expectation as etiology" or the "good old days" bias (EE/GOD bias) may partially explain persistent symptoms following mild traumatic brain injury (MTBI). What is less clear from existing research is the degree to which EE/GOD bias is related to other psychological correlates of persistent post-concussive symptoms (PPCS). We examined whether the EE/GOD bias was related to illness perception beliefs, intolerance of uncertainty, suggestibility, and domain identification. Participants with MTBI history and without (controls) reported frequency and severity of current PPCS; the MTBI group additionally reported premorbid PPCS. Participants also completed measures of psychological factors potentially associated with PPCS. Consistent with previous studies of the EE/GOD bias, the MTBI group endorsed less premorbid PPCS than current PPCS and when compared to the current symptom report of the control group. The MTBI group also endorsed more current PPCS than the control group. Higher EE/GOD bias was associated with several aspects of illness identity, including belief that symptoms would be more chronic, greater illness-related psychological distress, and greater cogniphobia. Higher EE/GOD bias was also related to higher intolerance of uncertainty and stronger personal identification with memory abilities. Regression showed that perceived symptom timeline, cogniphobia, and domain identification were unique predictors of EE/GOD bias. Findings confirm that the EE/GOD bias is seen in individuals with self-reported history of MTBI and corresponds to other psychological processes that potentially explain ongoing MTBI symptoms, providing greater insight into the potential mechanisms of PPCS. Future studies should examine the EE/GOD bias and associated psychological correlates in a clinical population and also assess for potential neuropsychological correlates. Findings suggest that psychological factors and premorbid symptom report should be considered in clinical assessment and also suggest potential mechanisms of treatment of individuals with acute MTBI or prolonged MTBI symptoms.

Objective: Social cognition is essential for individuals to perceive, process, and interpret social information that enables them to function effectively in society. Korsakoff's syndrome (KS) and alcohol-related dementia (ARD) are alcohol-related cognitive disorders that are likely to impair social cognition. This study aimed to investigate the ability to judge social norms in KS and ARD in comparison to healthy subjects.

Method: The study included 30 patients with KS, 10 patients with ARD, and 74 age-, sex-, and education-matched control participants. The Social Norms Questionnaire - Dutch version (SNQ-NL) was used to measure social cognition, and standardized tests were used to examine the association between social cognition and executive functioning.

Results: Both KS and ARD patients performed worse in judging social norms when compared to healthy controls, but there was no significant difference between KS and ARD. Both KS and ARD patients performed worse on the SNQ-NL, judging appropriate behavior as inappropriate (Overadhere errors), than controls. When compared to control participants, patients with KS demonstrated significantly more Break Errors, while the differences between the ARD group and the control group did not reach statistical significance. There were no significant correlations between the SNQ-NL variables and performances on standardized tests for executive functioning in both the KS and control group.

Conclusions: This study aimed to investigate the ability to judge social norms in KS and ARD in comparison to healthy subjects. The results show that compared to a control group, both KS and ARD patients performed worse in judging social norms. KS and ARD patients scored equally low on social norms identification. Overall, these findings can further help us understand the difficulties in social behavior as experienced by patients and care staff, since problems in accurately judging social norms could possibly contribute to the severe behavioral issues as observed in alcohol-related disorders.

Introduction: Patients with alcohol use disorder (AUD) may have distortions in time perception. This study investigated subjective time dilation (the tendency to perceive a time interval longer than it is) and its association with craving and impulsivity in AUD.

Method: Thirty abstinent male inpatients with AUD (age 29-60 years) and thirty sex-, age-, and education-matched healthy controls completed a temporal generalization task, which assessed the preference (point of subjective equality, PSE) and sensitivity of time perception in the second range. Craving for alcohol was assessed using the Alcohol Urge Questionnaire. Impulsivity was assessed using a delay discounting task and the Barratt Impulsiveness Scale-11. A comprehensive battery of neuropsychological tests was used to measure executive function (flanker task, symbol digit modalities test, trail-making test-A/B), negative emotionality (Beck Depression Inventory-II, Self-rating Anxiety Scale), and incentive salience (monetary incentive delay task) following the Addictions Neuroclinical Assessment (ANA) framework.

Results: AUD patients exhibited a smaller PSE than healthy controls, perceiving a time interval 8% longer than it was. AUD patients with a smaller PSE showed a greater craving for alcohol but not greater impulsivity. Exploratory factor analysis incorporating the PSE and ANA measures revealed four latent factors. The PSE loaded highly onto a factor reflecting time perception but not three other factors reflecting executive function, negative emotionality, and incentive salience.

Conclusions: AUD patients exhibit a pathological form of subjective time dilation, which is associated with a greater craving for alcohol. Time perception may be an independent functional dimension for understanding addictive behaviors in AUD.

Introduction: Neck muscle vibration (NMV) has been proposed as a bottom-up intervention to enhance visuospatial exploration in post-stroke patients with unilateral spatial neglect (USN). While some studies report enlarged visual exploration during NMV application, others find no significant impact, highlighting inconsistencies in the literature. The diversity in NMV application methods and the variation in visuospatial outcome measures may contribute to these conflicting findings. This study aimed to overview the methodological approaches used to investigate NMV's effects on visuospatial behavior in USN patients, focusing on aspects beyond sample size and study design.

Methods: Among the seven databases, studies that applied NMV and assessed visual or perceptual outcomes were included in the analysis. Two independent reviewers screened titles and abstracts to select the studies to analyze. Data about the publication, population, modalities of application, and outcomes were extracted and synthesized.

Results: Twenty-five publications from 1988 to 2023 were included, involving a total of 512 participants, of whom 114 (22.3%) had USN. The presence of USN was assessed based on paper-and-pencil tests. The frequency of NMV was set between 80 and 125 hz. In 22 studies, NMV were applied on the left side of the neck muscles. Six studies proposed multiple NMV sessions, lasting between 5 and 50 minutes/day, 3-5 times/week, for 2-4 weeks. One study included a follow-up period of up to 1.4 years. The tasks during NMV often involved indicating the subjective straight ahead (SSA, n = 8), pointing out targets, or no specific activity (n = 7, each). The SSA and cancellation tests were the most frequent outcomes.

Conclusions: NMV application modalities varied widely across studies, with only vibration frequency showing consistency. The tasks performed during NMV and the outcome measures were diverse and generally unrelated to activities of daily living. Therefore, NMV effects during more ecologically valid tasks should be explored.

Objective: Prior research suggests that effort and reward are central to cognitive fatigue. To better understand the influence of reward on cognitive fatigue, this study examined the effect of reward type and frequency on cognitive fatigue.

Participants and methods: In an online between-subjects study, 400 participants completed a computerized switching task and were randomly sorted into one of the five possible groups based on reward condition: [1] infrequent money, [2] frequent money, [3] infrequent performance-feedback, [4] frequent performance feedback, and [5] no-reward. Cognitive fatigue was assessed using the Visual Analog Scale for Fatigue (VAS-F) during the task. Mixed effects models were used to estimate the influence of reward type and frequency on task performance and cognitive fatigue.

Results: We found that participants in the monetary groups were significantly faster (p < .001) compared to participants in the feedback and no-reward groups. We also found that participants in the frequent-money group were significantly faster than those in the infrequent-money group (p < .001). We found that the group receiving infrequent-money was associated with a decrease in VAS-F scores compared to no-reward (p = .04).

Conclusions: The current study supports the role of reward in cognitive fatigue. Our results confirm well-established findings that money positively influences on-task behavior, especially when money is provided frequently. In a cognitively healthy sample, there is some evidence to suggest that money provided infrequently could decrease feelings of fatigue. Continued work is needed to understand how, and which, specific behavioral reward manipulations reduce fatigue, especially in clinical populations most affected by fatigue.

Objective: This study investigated the relationship between processing speed impairment severity and performance on the Rey 15-Item Test (RFIT) and RFIT + Recognition.

Method: Cross-sectional data from 285 examinees (228 valid/57 invalid) referred for neuropsychological assessment who were administered the RFIT, Weschler Adult Intelligence Scale-Fourth Edition (WAIS-IV) Processing Speed Index (PSI), Brief Visuospatial Memory Test - Revised, Rey Auditory Verbal Learning Test, and three independent criterion PVTs were included. PSI bands were operationalized as Intact (≥85SS; n = 163), Reduced/Possibly Impaired (77-84SS; n = 36), or Impaired (≤76 SS; n = 29). Receiver operator characteristic (ROC) curve analyses tested the RFIT and RFIT + Recognition's classification accuracy for detecting invalid performance for the overall sample and by PSI impairment status.

Results: Those with intact processing speed performed significantly better on the RFIT and RFIT + Recognition than those with reduced/possibly impaired and impaired processing speed. Though verbal/visual memory predicted RFIT scores independently, PSI contributed additional variance. ROC curves for RFIT and RFIT + Recognition were significant (AUC=.64-.84). Optimal cut-scores yielded modest sensitivity (30%-63%) and high specificity (89%-93%) among those with intact and reduced processing speed but yielded unacceptable accuracy in those with impaired speed (AUC=.59-.62).

Conclusions: Although the RFIT and RFIT + Recognition demonstrated acceptable classification accuracy in those with intact processing speed, accuracy diminished with increasing speed impairment. This finding was more pronounced for RFIT + Recognition compared to the traditional RFIT. As such, the RFIT may have limited clinical utility in examinees with more significant processing speed deficits.

Objectives: Despite the established impact of care recipient cognitive impairment on care partner (CP) distress, limited quantitative research has explored how social and leisure engagement may moderate this relationship, offering a potential avenue for enhancing well-being in both care partners and recipients. The current study therefore examined the between- and within-dyad associations between cognitive impairment of persons with dementia (PwD) and their family CP's distress, and whether social and leisure activity moderated this relationship.

Methods: Data were utilized from dyads (PwD, n = 33, and their CPs, n = 34) engaged in the Voices in Motion project, a social-cognitive choral intervention for PwD and their family CPs. Measures indexing PwD cognitive status, CP distress, and PwD and CP social and leisure engagement were assessed using an intensive repeated-measures burst design, with multilevel models of change employed to disaggregate between- and within-person effects.

Results: Diminished cognitive functioning in PwD was associated with increased CP distress (p < 0.01) between-dyads; however, this relationship was not significant within-dyads. The between-dyad association was significantly moderated by the extent of social and leisure engagement of both CPs (p < .001) and PwD (p = .04). Follow-up simple slopes demonstrated that, at mean- and high-levels (+1SD) of social and leisure engagement for PwD and/or CP, increased PwD cognitive function significantly predicted lower CP distress.

Conclusion: The significant moderating influence of social and leisure engagement of dyads underscores the protective role of such engagement for reducing care-related distress. Activity engagement for CPs and PwD may help modulate the deleterious impact of PwD cognitive impairment and attenuate CP distress. These findings highlight the potential for dyadic interventions that promote social and leisure activities to mitigate caregiving challenges and enhance quality of life for both CPs and PwD.