K. A. Hawsawi, Rehab Aser, Z. Khoj, Ghassan M Barnawi, Waseem K. Alhawsawi
{"title":"Dowling–Degos disease: A case report of a follicular variant","authors":"K. A. Hawsawi, Rehab Aser, Z. Khoj, Ghassan M Barnawi, Waseem K. Alhawsawi","doi":"10.4103/JDDS.JDDS_32_20","DOIUrl":"https://doi.org/10.4103/JDDS.JDDS_32_20","url":null,"abstract":"","PeriodicalId":15535,"journal":{"name":"Journal of Dermatology and Dermatologic Surgery","volume":"6 1","pages":"46"},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89900153","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pembrolizumab is a humanized monoclonal antibody that targets programmed cell death receptor-1. Stevens–Johnson syndrome (SJS) secondary to pembrolizumab has rarely been described in the treatment of malignant melanoma (MM). A 62-year-old woman developed a widespread bullous eruption following administration of her third dose of pembrolizumab for the treatment of MM. A skin biopsy showed sub-epidermal bulla formation with lymphocytic infiltrate and a necrotic roof, consistent with a SJS/toxic epidermal necrolysis (TEN) disorder. Intravenous methylprednisolone was administered. Upon cessation of oral prednisolone, there was a recrudescence of the eruption. A repeat skin biopsy confirmed recurrent SJS. Following a prolonged taper with oral prednisolone, there was no further relapse of SJS. Severe cutaneous adverse reactions such as SJS/TEN have been reported with pembrolizumab and can be associated with significant morbidity and even mortality. High-dose systemic corticosteroids are frequently used in its treatment. Concerns about the potential negative effect of high-dose steroids have re-surfaced, given the observed reduced overall survival in patients with MM. Due to difficulties in performing studies in this population, the benefits and risk of steroids should be considered on a case-by-case basis.
{"title":"Atypical Stevens–Johnson syndrome caused by pembrolizumab in the treatment of metastatic melanoma – Are corticosteroids a safe treatment option?","authors":"C. O'Connor, E. Jordan, M. O'Connell","doi":"10.4103/jdds.jdds_73_20","DOIUrl":"https://doi.org/10.4103/jdds.jdds_73_20","url":null,"abstract":"Pembrolizumab is a humanized monoclonal antibody that targets programmed cell death receptor-1. Stevens–Johnson syndrome (SJS) secondary to pembrolizumab has rarely been described in the treatment of malignant melanoma (MM). A 62-year-old woman developed a widespread bullous eruption following administration of her third dose of pembrolizumab for the treatment of MM. A skin biopsy showed sub-epidermal bulla formation with lymphocytic infiltrate and a necrotic roof, consistent with a SJS/toxic epidermal necrolysis (TEN) disorder. Intravenous methylprednisolone was administered. Upon cessation of oral prednisolone, there was a recrudescence of the eruption. A repeat skin biopsy confirmed recurrent SJS. Following a prolonged taper with oral prednisolone, there was no further relapse of SJS. Severe cutaneous adverse reactions such as SJS/TEN have been reported with pembrolizumab and can be associated with significant morbidity and even mortality. High-dose systemic corticosteroids are frequently used in its treatment. Concerns about the potential negative effect of high-dose steroids have re-surfaced, given the observed reduced overall survival in patients with MM. Due to difficulties in performing studies in this population, the benefits and risk of steroids should be considered on a case-by-case basis.","PeriodicalId":15535,"journal":{"name":"Journal of Dermatology and Dermatologic Surgery","volume":"73 1","pages":"137 - 139"},"PeriodicalIF":0.0,"publicationDate":"2020-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77009700","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Jennifer Seyffert, T. Harding, A. Sanghvi, Nathan Bibliowicz, Martin Yungmann, Shawn Camner, Matt L. Leavitt, J. Solomon
Background: Surgical wound dehiscence (SWD) is the third most common adverse event following dermatologic surgery. There have been no previous studies investigating risk factors for SWD following dermatologic surgery. There are no formal recommendations or standards of care to minimize or prevent SWD following dermatologic surgery. Purpose: The purpose of this study was to identify risk factors associated with dermatologic SWD. Methods: Multicenter retrospective data mined from EMA electronic medical record were collected from 22,548 matched excisions and postoperative visits performed on patients ≥18 years between January 1, 2019, and September 27, 2019. Matched data analysis was performed using IBM SPSS Statistics 25 to elucidate factors associated with SWD. Results: The prevalence of SWD was calculated to be 0.55%. A wound reported as positive for presumed infection or postoperative bleeding had 14.48 and 20.15 times the odds, respectively, of also being positive for SWD. A wound located on distal extremities (arm, hand, and lower leg) had 1.86 times the odds of being positive for SWD. Increasing age was found to be statistically significant. Wounds on individuals 80 years of age or greater had 1.7064 times the odds of being positive for SWD. Data did not support a correlation between SWD and sex, SWD and diabetes, or SWD and provider type. Conclusion: Factors that contribute to SWD dehiscence include presence of presumed infection, presence of bleeding, age >80, and location on the distal extremity. Data did not support a correlation between SWD and sex, SWD and diabetes, or SWD and provider type. Dermatologic surgeon identification and reduction of risk factors contributing to this adverse event may prevent SWD.
{"title":"Surgical wound dehiscence following cutaneous excisions: A retrospective study and review of the literature","authors":"Jennifer Seyffert, T. Harding, A. Sanghvi, Nathan Bibliowicz, Martin Yungmann, Shawn Camner, Matt L. Leavitt, J. Solomon","doi":"10.4103/jdds.jdds_71_20","DOIUrl":"https://doi.org/10.4103/jdds.jdds_71_20","url":null,"abstract":"Background: Surgical wound dehiscence (SWD) is the third most common adverse event following dermatologic surgery. There have been no previous studies investigating risk factors for SWD following dermatologic surgery. There are no formal recommendations or standards of care to minimize or prevent SWD following dermatologic surgery. Purpose: The purpose of this study was to identify risk factors associated with dermatologic SWD. Methods: Multicenter retrospective data mined from EMA electronic medical record were collected from 22,548 matched excisions and postoperative visits performed on patients ≥18 years between January 1, 2019, and September 27, 2019. Matched data analysis was performed using IBM SPSS Statistics 25 to elucidate factors associated with SWD. Results: The prevalence of SWD was calculated to be 0.55%. A wound reported as positive for presumed infection or postoperative bleeding had 14.48 and 20.15 times the odds, respectively, of also being positive for SWD. A wound located on distal extremities (arm, hand, and lower leg) had 1.86 times the odds of being positive for SWD. Increasing age was found to be statistically significant. Wounds on individuals 80 years of age or greater had 1.7064 times the odds of being positive for SWD. Data did not support a correlation between SWD and sex, SWD and diabetes, or SWD and provider type. Conclusion: Factors that contribute to SWD dehiscence include presence of presumed infection, presence of bleeding, age >80, and location on the distal extremity. Data did not support a correlation between SWD and sex, SWD and diabetes, or SWD and provider type. Dermatologic surgeon identification and reduction of risk factors contributing to this adverse event may prevent SWD.","PeriodicalId":15535,"journal":{"name":"Journal of Dermatology and Dermatologic Surgery","volume":"34 6 1","pages":"93 - 98"},"PeriodicalIF":0.0,"publicationDate":"2020-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77235150","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Nadia A. El Sherif, A. Elorfi, O. Bugrein, Soad Eldruki
Background: Mycosis fungoides (MF) represents the most common form of primary cutaneous T-cell lymphoma (CTCL) often with an indolent course. Purpose: The objective is to determine epidemiological and clinical features of MF among Libyan patients. Methods: Clinical and histopathological evaluation was carried out in 24 patients with MF in the Department of Dermatology at El-Jumhoria Hospital in Benghazi city between 2010 and 2019. Results: Twenty-four patients with a diagnosis of MF, 11 were female and 13 were male. Age of the patients ranged between 30 and 60 year with a mean of age ± standard deviation of 47.4 ± 8 years. Clinical presentation with patches and plaques was most common, seen in 58.3% of the patients. Poikilodermatous MF was seen in 37.5% patients, hypopigmented MF seen in 12.5% of patients, follicular MF seen in 8.3% of patients, and 8.3% patients had lymphomatoid papulosis. Pruritis was the complaint of 75% of the patients. About 25% of the patients had blood eosinophilia, 33.3% had raised lactic dehydrogenase enzyme. Tumor-node-metastasis-blood (TNMB) classification of the patients revealed that 66.7% had stage IB, 20.8% of patients had stage IIA, 8.3% of patients had stage IIB, and 4.2% patients had stage IVa. About 70.8% of patients received systemic Psoralen and ultraviolet A (PUVA) therapy, 20.8% patients received narrow band ultraviolet B, 4.2% patients treated with radiotherapy, and 4.2% patients received both chemotherapy and radiotherapy. About 45.8% of patients show remission of their disease, 12.5% patients show no response, 8.3% of patients still under treatment, 25% of patients lost follow-up, and 8.3% patients died. Conclusion: MF is a low-grade primary CTCL with different clinical presentations with variable response to therapy.
{"title":"Clinical and epidemiological profile of libyan patients with mycosis fungoides: A prospective study","authors":"Nadia A. El Sherif, A. Elorfi, O. Bugrein, Soad Eldruki","doi":"10.4103/jdds.jdds_24_20","DOIUrl":"https://doi.org/10.4103/jdds.jdds_24_20","url":null,"abstract":"Background: Mycosis fungoides (MF) represents the most common form of primary cutaneous T-cell lymphoma (CTCL) often with an indolent course. Purpose: The objective is to determine epidemiological and clinical features of MF among Libyan patients. Methods: Clinical and histopathological evaluation was carried out in 24 patients with MF in the Department of Dermatology at El-Jumhoria Hospital in Benghazi city between 2010 and 2019. Results: Twenty-four patients with a diagnosis of MF, 11 were female and 13 were male. Age of the patients ranged between 30 and 60 year with a mean of age ± standard deviation of 47.4 ± 8 years. Clinical presentation with patches and plaques was most common, seen in 58.3% of the patients. Poikilodermatous MF was seen in 37.5% patients, hypopigmented MF seen in 12.5% of patients, follicular MF seen in 8.3% of patients, and 8.3% patients had lymphomatoid papulosis. Pruritis was the complaint of 75% of the patients. About 25% of the patients had blood eosinophilia, 33.3% had raised lactic dehydrogenase enzyme. Tumor-node-metastasis-blood (TNMB) classification of the patients revealed that 66.7% had stage IB, 20.8% of patients had stage IIA, 8.3% of patients had stage IIB, and 4.2% patients had stage IVa. About 70.8% of patients received systemic Psoralen and ultraviolet A (PUVA) therapy, 20.8% patients received narrow band ultraviolet B, 4.2% patients treated with radiotherapy, and 4.2% patients received both chemotherapy and radiotherapy. About 45.8% of patients show remission of their disease, 12.5% patients show no response, 8.3% of patients still under treatment, 25% of patients lost follow-up, and 8.3% patients died. Conclusion: MF is a low-grade primary CTCL with different clinical presentations with variable response to therapy.","PeriodicalId":15535,"journal":{"name":"Journal of Dermatology and Dermatologic Surgery","volume":"23 1","pages":"99 - 104"},"PeriodicalIF":0.0,"publicationDate":"2020-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87556997","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Background: There is a paucity of the epidemiologic studies of alopecia areata (AA) in Arab countries, especially from Saudi Arabia. Purpose: The aim was to describe the epidemiological and the clinical features of AA and its associated disease in Jeddah, Saudi Arabia. Methods: A retrospective review of medical records of 83 patients with AA seen at King Abdulaziz Medical City, Jeddah, was performed between July 2017 and July 2018. AA was classified into mild (with <10% scalp involvement and AA limited to beard area), moderate (patchy AA with <50% scalp involvement), and severe (alopecia universalis, ophiasis, alopecia totalis, and patchy AA with ≥ 50% scalp involvement). Results: The most common types of AA were mild patchy AA with <10% scalp in 35 (42.2%) patients, followed by AA limited to beard area in 24 (28.9%). The most common associated disease was atopic dermatitis which was seen in 10 (12%) patients, followed by thyroid disorder in 9 (10.8%). The most common treatment was intralesional corticosteroid (79.7% of mild and 83% of moderate) for mild and moderate and diphencyprone for severe AA (44.4%). Conclusion: Early age of onset is associated with more severe AA. The most commonly associated diseases are atopic dermatitis and thyroid disorder.
{"title":"The clinico-epidemiological profile of alopecia areata: A hospital-based study in Jeddah, Saudi Arabia","authors":"T. Mahjoub","doi":"10.4103/jdds.jdds_77_19","DOIUrl":"https://doi.org/10.4103/jdds.jdds_77_19","url":null,"abstract":"Background: There is a paucity of the epidemiologic studies of alopecia areata (AA) in Arab countries, especially from Saudi Arabia. Purpose: The aim was to describe the epidemiological and the clinical features of AA and its associated disease in Jeddah, Saudi Arabia. Methods: A retrospective review of medical records of 83 patients with AA seen at King Abdulaziz Medical City, Jeddah, was performed between July 2017 and July 2018. AA was classified into mild (with <10% scalp involvement and AA limited to beard area), moderate (patchy AA with <50% scalp involvement), and severe (alopecia universalis, ophiasis, alopecia totalis, and patchy AA with ≥ 50% scalp involvement). Results: The most common types of AA were mild patchy AA with <10% scalp in 35 (42.2%) patients, followed by AA limited to beard area in 24 (28.9%). The most common associated disease was atopic dermatitis which was seen in 10 (12%) patients, followed by thyroid disorder in 9 (10.8%). The most common treatment was intralesional corticosteroid (79.7% of mild and 83% of moderate) for mild and moderate and diphencyprone for severe AA (44.4%). Conclusion: Early age of onset is associated with more severe AA. The most commonly associated diseases are atopic dermatitis and thyroid disorder.","PeriodicalId":15535,"journal":{"name":"Journal of Dermatology and Dermatologic Surgery","volume":"7 1","pages":"122 - 124"},"PeriodicalIF":0.0,"publicationDate":"2020-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81573997","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Background: pH is increasingly a target in therapeutic strategies for skin barrier repair, but the relationship between pH, transepidermal water loss (TEWL), and atopic dermatitis (AD) severity is not well characterized. Purpose: The purpose of the study was to determine the relationship between skin pH with TEWL and their correlations with AD severity. Methods: A cross-sectional study enrolled children aged 4–12 years with AD. Measurements were made using HI 99181 and Tewameter TM 300 at two lesional sites and two nonlesional sites (left cubital fossa, left thigh, and forehead). Disease severity was evaluated using the Eczema Area and Severity Index (EASI) and pruritus score. Results: A total of 14 (58%) girls and 10 (42%) boys aged 7.3 ± 2.6 years with age of AD onset 3.0 ± 2.1 years participated. The mean EASI score was 8.9 ± 8.2, body surface area 13.1% ± 18.5%, pruritus score 5.9 ± 2.7, and Children Dermatology Life Quality Index 5.6 ± 4.9. pH and TEWL were higher at lesional compared to nonlesional skin, pH 5.2 ± 0.7 versus 4.6 ± 0.4, P < 0.01 and TEWL 31.1 ± 15.2 versus 16.0 ± 10.2, P < 0.01. Lesional pH positively correlated with TEWL (r = 0.59, P= 0.02 and r = 0.55, P = 0.01), while nonlesional pH was inversely correlated (r = −0.42,P = 0.04 and r = −0.40, P = 0.05). pH showed significant positive correlations with EASI and itch at one lesional site. Conclusion: pH and TEWL were higher at lesional skin. pH correlated positively with TEWL at lesional skin but inversely at nonlesional areas. Higher pH was associated with disease severity and itch. pH restoration may have therapeutic potential in AD.
{"title":"Skin pH and its relationship with transepidermal water loss and disease severity in children with atopic dermatitis: A cross-sectional study","authors":"C. Lee, A. Jamil","doi":"10.4103/jdds.jdds_33_20","DOIUrl":"https://doi.org/10.4103/jdds.jdds_33_20","url":null,"abstract":"Background: pH is increasingly a target in therapeutic strategies for skin barrier repair, but the relationship between pH, transepidermal water loss (TEWL), and atopic dermatitis (AD) severity is not well characterized. Purpose: The purpose of the study was to determine the relationship between skin pH with TEWL and their correlations with AD severity. Methods: A cross-sectional study enrolled children aged 4–12 years with AD. Measurements were made using HI 99181 and Tewameter TM 300 at two lesional sites and two nonlesional sites (left cubital fossa, left thigh, and forehead). Disease severity was evaluated using the Eczema Area and Severity Index (EASI) and pruritus score. Results: A total of 14 (58%) girls and 10 (42%) boys aged 7.3 ± 2.6 years with age of AD onset 3.0 ± 2.1 years participated. The mean EASI score was 8.9 ± 8.2, body surface area 13.1% ± 18.5%, pruritus score 5.9 ± 2.7, and Children Dermatology Life Quality Index 5.6 ± 4.9. pH and TEWL were higher at lesional compared to nonlesional skin, pH 5.2 ± 0.7 versus 4.6 ± 0.4, P < 0.01 and TEWL 31.1 ± 15.2 versus 16.0 ± 10.2, P < 0.01. Lesional pH positively correlated with TEWL (r = 0.59, P= 0.02 and r = 0.55, P = 0.01), while nonlesional pH was inversely correlated (r = −0.42,P = 0.04 and r = −0.40, P = 0.05). pH showed significant positive correlations with EASI and itch at one lesional site. Conclusion: pH and TEWL were higher at lesional skin. pH correlated positively with TEWL at lesional skin but inversely at nonlesional areas. Higher pH was associated with disease severity and itch. pH restoration may have therapeutic potential in AD.","PeriodicalId":15535,"journal":{"name":"Journal of Dermatology and Dermatologic Surgery","volume":"38 1","pages":"84 - 87"},"PeriodicalIF":0.0,"publicationDate":"2020-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91465361","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
H. Rajegowda, Deepadarshan Kalegowda, S. Madegowda, Jayashree Palanayak
Background: Warts are benign tumors caused by infection of keratinocytes with human papillomavirus. Various modalities are available for the treatment of cutaneous warts such as destructive procedures, surgical methods, and immunotherapy. Recently, immunotherapy with intralesional antigens/vaccines is emerging as a novel method with encouraging results. Purpose: The study aimed to compare the efficacy of intralesional mumps, measles, and rubella (MMR) vaccine versus cryotherapy in the treatment of cutaneous warts. Methods: In this prospective study, 60 clinically diagnosed cases of cutaneous warts were enrolled and randomly divided into two groups of 30 each. Patients of Group A received 0.5 ml of reconstituted MMR vaccine, which was injected into the largest wart. The dose was repeated at 3-week intervals until complete clearance or for a maximum of 3 doses. In Group B, patients received cryotherapy with liquid nitrogen at weekly intervals for a maximum of 9 sessions. Patients of both the groups were followed up at the 3rd, 6th, and 9th weeks to evaluate clinical outcome on the Visual Analog Scale. Statistical analysis was done by the Chi-square test using SPSS software. Results: Out of 30 patients, 63.3% (19) of the patients of Group A showed complete clearance of warts compared with 33.3% (10) of the patients of Group B at the end of 9 weeks. Adverse effects were more with cryotherapy including pain, blistering, and depigmentation, whereas immunotherapy was well-tolerated except for the pain during injection. Conclusion: Intralesional MMR vaccine immunotherapy was more effective, with an added advantage of regression of distant warts, fewer sessions, and no serious side effects.
{"title":"Intralesional measles, mumps, and rubella vaccine versus cryotherapy in treatment of warts: A prospective study","authors":"H. Rajegowda, Deepadarshan Kalegowda, S. Madegowda, Jayashree Palanayak","doi":"10.4103/jdds.jdds_60_20","DOIUrl":"https://doi.org/10.4103/jdds.jdds_60_20","url":null,"abstract":"Background: Warts are benign tumors caused by infection of keratinocytes with human papillomavirus. Various modalities are available for the treatment of cutaneous warts such as destructive procedures, surgical methods, and immunotherapy. Recently, immunotherapy with intralesional antigens/vaccines is emerging as a novel method with encouraging results. Purpose: The study aimed to compare the efficacy of intralesional mumps, measles, and rubella (MMR) vaccine versus cryotherapy in the treatment of cutaneous warts. Methods: In this prospective study, 60 clinically diagnosed cases of cutaneous warts were enrolled and randomly divided into two groups of 30 each. Patients of Group A received 0.5 ml of reconstituted MMR vaccine, which was injected into the largest wart. The dose was repeated at 3-week intervals until complete clearance or for a maximum of 3 doses. In Group B, patients received cryotherapy with liquid nitrogen at weekly intervals for a maximum of 9 sessions. Patients of both the groups were followed up at the 3rd, 6th, and 9th weeks to evaluate clinical outcome on the Visual Analog Scale. Statistical analysis was done by the Chi-square test using SPSS software. Results: Out of 30 patients, 63.3% (19) of the patients of Group A showed complete clearance of warts compared with 33.3% (10) of the patients of Group B at the end of 9 weeks. Adverse effects were more with cryotherapy including pain, blistering, and depigmentation, whereas immunotherapy was well-tolerated except for the pain during injection. Conclusion: Intralesional MMR vaccine immunotherapy was more effective, with an added advantage of regression of distant warts, fewer sessions, and no serious side effects.","PeriodicalId":15535,"journal":{"name":"Journal of Dermatology and Dermatologic Surgery","volume":"26 1","pages":"110 - 115"},"PeriodicalIF":0.0,"publicationDate":"2020-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76221219","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Z. Mizaj, Spandana P Hegde, Guruprasad Bhat, Vishal B Amin, M. Pinto, M. Shenoy
Background: Anticancer chemotherapy is associated with multisystem adverse effects. Chemotherapy can affect skin, nails, and hair and may sometimes affect the quality of life to the point of requiring discontinuation of therapy. There are many new chemotherapeutic agents, and with that, a rise in the adverse effects attributed to them. Purpose: To evaluate the frequency of nail changes occurring due to anticancer therapy. Methods: We screened 100 cancer patients admitted in the oncology ward of a tertiary care center in South India from July to September 2017. The nail changes were documented and analyzed with emphasis on developing a relationship if any with a chemotherapeutic agent. Results: Nail changes were observed in 62 (62%) cases. Breast carcinoma (20 cases) was the most common malignancy. Doxorubicin (36 cases) and cyclophosphamide (27 cases) were the most common chemotherapeutic drugs associated with nail changes. Pigmentary changes (32 cases) were the most common nail plate changes. Blue lunula (24 cases) was the most common nail bed change, occurring with cyclophosphamide/doxorubicin. Pyogenic granuloma was the only nail fold change that was noted in a patient of carcinoma of breast treated with gefitinib. Conclusion: Cancer chemotherapy may be associated with a variety of nail changes. Addressing nail changes may have the potential to improve cancer treatment patients' quality of life.
{"title":"Nail manifestations in cancer chemotherapy: A cross-sectional study","authors":"Z. Mizaj, Spandana P Hegde, Guruprasad Bhat, Vishal B Amin, M. Pinto, M. Shenoy","doi":"10.4103/jdds.jdds_79_20","DOIUrl":"https://doi.org/10.4103/jdds.jdds_79_20","url":null,"abstract":"Background: Anticancer chemotherapy is associated with multisystem adverse effects. Chemotherapy can affect skin, nails, and hair and may sometimes affect the quality of life to the point of requiring discontinuation of therapy. There are many new chemotherapeutic agents, and with that, a rise in the adverse effects attributed to them. Purpose: To evaluate the frequency of nail changes occurring due to anticancer therapy. Methods: We screened 100 cancer patients admitted in the oncology ward of a tertiary care center in South India from July to September 2017. The nail changes were documented and analyzed with emphasis on developing a relationship if any with a chemotherapeutic agent. Results: Nail changes were observed in 62 (62%) cases. Breast carcinoma (20 cases) was the most common malignancy. Doxorubicin (36 cases) and cyclophosphamide (27 cases) were the most common chemotherapeutic drugs associated with nail changes. Pigmentary changes (32 cases) were the most common nail plate changes. Blue lunula (24 cases) was the most common nail bed change, occurring with cyclophosphamide/doxorubicin. Pyogenic granuloma was the only nail fold change that was noted in a patient of carcinoma of breast treated with gefitinib. Conclusion: Cancer chemotherapy may be associated with a variety of nail changes. Addressing nail changes may have the potential to improve cancer treatment patients' quality of life.","PeriodicalId":15535,"journal":{"name":"Journal of Dermatology and Dermatologic Surgery","volume":"2 1","pages":"88 - 92"},"PeriodicalIF":0.0,"publicationDate":"2020-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79543527","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
A. Alsubhi, N. Salem, Maryam Mohab, Bashaer Alghamdi, Nouf Alghamdi, Raniya A. Alasiri, Rajwa A Sindi, Raneem A. Almastadi, Noor M Alfayez, Mawaddah Alsulaimani, Weaam Alsheikh, S. Alhamed, H. Mawardi
Background: Oral lichen planus is a chronic, immune-mediated disease that can impact the oral cavity significantly. Treatment options include topical and systemic corticosteroid therapy based on the disease severity. Intra-lesional corticosteroid injections (ILCI) have been incorporated in clinical practice as an effective modality to deliver treatment locally to expedite the healing process while limiting systemic toxicity. Purpose: The objective of this systematic review was to evaluate the role of ILCI in treating OLP. Methods: A systematic review of the literature was conducted in the PubMed and Web of Science databases following PRISMA protocol and up to September 2019. All English-language literature on ILCI for OLP was included. Relevant articles were systematically reviewed using multiple levels of elimination by title, abstract, and full text. Data from the included studies were extracted and analyzed. A total of six studies met the inclusion criteria. Results: Triamcinolone acetonide intra-lesional injection demonstrated efficacy and rapid healing of OLP lesions in three studies. Minor adverse events of secondary oral candidiasis and cushingoid features were reported. Conclusion: ILCI may be considered as an effective treatment option for OLP lesions with minimal side effects and risk of disease relapse.
背景:口腔扁平苔藓是一种慢性、免疫介导的疾病，可显著影响口腔。治疗方案包括根据疾病严重程度局部和全身皮质类固醇治疗。病灶内皮质类固醇注射(ILCI)已被纳入临床实践，作为一种有效的局部治疗方式，以加速愈合过程，同时限制全身毒性。目的:本系统综述的目的是评估ILCI在治疗OLP中的作用。方法:根据PRISMA协议，对截至2019年9月的PubMed和Web of Science数据库中的文献进行系统综述。所有关于OLP的ILCI的英语文献都被包括在内。通过标题、摘要和全文等多个层次的排除，系统地审查了相关文章。从纳入的研究中提取数据并进行分析。共有6项研究符合纳入标准。结果:三项研究表明，曲安奈德病灶内注射对OLP病变有良好的疗效和快速愈合。报告了继发性口腔念珠菌病的轻微不良事件和库欣样特征。结论:ILCI可被认为是OLP病变的有效治疗选择，副作用小，疾病复发风险小。
{"title":"Intralesional corticosteroid injections for the treatment of oral lichen planus: A systematic review","authors":"A. Alsubhi, N. Salem, Maryam Mohab, Bashaer Alghamdi, Nouf Alghamdi, Raniya A. Alasiri, Rajwa A Sindi, Raneem A. Almastadi, Noor M Alfayez, Mawaddah Alsulaimani, Weaam Alsheikh, S. Alhamed, H. Mawardi","doi":"10.4103/jdds.jdds_76_19","DOIUrl":"https://doi.org/10.4103/jdds.jdds_76_19","url":null,"abstract":"Background: Oral lichen planus is a chronic, immune-mediated disease that can impact the oral cavity significantly. Treatment options include topical and systemic corticosteroid therapy based on the disease severity. Intra-lesional corticosteroid injections (ILCI) have been incorporated in clinical practice as an effective modality to deliver treatment locally to expedite the healing process while limiting systemic toxicity. Purpose: The objective of this systematic review was to evaluate the role of ILCI in treating OLP. Methods: A systematic review of the literature was conducted in the PubMed and Web of Science databases following PRISMA protocol and up to September 2019. All English-language literature on ILCI for OLP was included. Relevant articles were systematically reviewed using multiple levels of elimination by title, abstract, and full text. Data from the included studies were extracted and analyzed. A total of six studies met the inclusion criteria. Results: Triamcinolone acetonide intra-lesional injection demonstrated efficacy and rapid healing of OLP lesions in three studies. Minor adverse events of secondary oral candidiasis and cushingoid features were reported. Conclusion: ILCI may be considered as an effective treatment option for OLP lesions with minimal side effects and risk of disease relapse.","PeriodicalId":15535,"journal":{"name":"Journal of Dermatology and Dermatologic Surgery","volume":"66 1","pages":"74 - 80"},"PeriodicalIF":0.0,"publicationDate":"2020-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90363835","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Background: Vitiligo is a common disorder characterized by depigmentation due to autoimmune destruction of melanocytes. The role of psychological stress in causing vitiligo is not well characterized. Purpose: This article aims at reviewing the role of stress in triggering and/or exacerbating vitiligo. Methods: Seven relevant studies were found in the literature search. Results: Most of the studies support the theory that stressful life events may trigger the onset or the progression of vitiligo. Conclusion: Studies depended mainly on retrospective reporting of stressful events could be a major source of bias.
{"title":"Does psychological stress trigger or exacerbate vitiligo: More data are needed","authors":"S. Almutairi, M. Aljasser","doi":"10.4103/jdds.jdds_26_19","DOIUrl":"https://doi.org/10.4103/jdds.jdds_26_19","url":null,"abstract":"Background: Vitiligo is a common disorder characterized by depigmentation due to autoimmune destruction of melanocytes. The role of psychological stress in causing vitiligo is not well characterized. Purpose: This article aims at reviewing the role of stress in triggering and/or exacerbating vitiligo. Methods: Seven relevant studies were found in the literature search. Results: Most of the studies support the theory that stressful life events may trigger the onset or the progression of vitiligo. Conclusion: Studies depended mainly on retrospective reporting of stressful events could be a major source of bias.","PeriodicalId":15535,"journal":{"name":"Journal of Dermatology and Dermatologic Surgery","volume":"31 1","pages":"81 - 83"},"PeriodicalIF":0.0,"publicationDate":"2020-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84026663","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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