Journal of Cosmetic Dermatology最新文献

{"title":"The Relationship Between Nutrition Habits, BMI, Anxiety, and Seborrheic Dermatitis","authors":"Tayfun Batan,&nbsp;Ersoy Acer,&nbsp;Hilal Kaya Erdoğan,&nbsp;Esra Ağaoğlu,&nbsp;Muzaffer Bilgin,&nbsp;Zeynep Nurhan Saraçoğlu","doi":"10.1111/jocd.16737","DOIUrl":"10.1111/jocd.16737","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Seborrheic dermatitis (SD) is a chronic, inflammatory disease characterized by unknown etiopathogenesis. It affects skin areas rich in sebaceous glands. There are strong data on the relationship between nutrition habits, body mass index (BMI), psychoemotional status, and sebaceous gland diseases such as acne, rosacea, and androgenetic alopecia. However, there are very little data on SD, nutrition habits, BMI, and psychoemotional status.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Aims</h3>\u0000 \u0000 <p>We aimed to evaluate the nutrition habits, BMI, and psychoemotional status in patients with SD.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>One hundred patients with SD and 110 healthy controls aged 18–65 years were included. Adolescents Food Habits Checklist (AFHC), a questionnaire form consisting information about nutrition habits and Depression Anxiety Stress Scale-21 (DASS-21) were completed by the participants, and BMI was calculated.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Severity of SD was positively correlated with BMI (<i>p</i> = 0.018). Patients with SD consumed more bread and less fruits–vegetables (<i>p</i> = 0.001, <i>p</i> = 0.006). Margarine, animal fat, and sugar consumption was higher in patients with moderate to severe SD (<i>p</i> = 0.008, <i>p</i> = 0.050). AFHC score was lower in patients with SD (<i>p</i> = 0.009). DASS-21 anxiety subscale and DASS-21 total scores were higher in the moderate to severe SD group (<i>p</i> = 0.035, <i>p</i> = 0.049).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Nutrition habits, higher BMI, and psychoemotional status may play a critical role in the etiopathogenesis of SD. Healthy nutrition habits and psychoemotional status may prevent the occurrence and exacerbation of SD.</p>\u0000 </section>\u0000 </div>","PeriodicalId":15546,"journal":{"name":"Journal of Cosmetic Dermatology","volume":"24 1","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-01-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jocd.16737","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142931989","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Subcision—The Art of Controlled Aggression","authors":"Davin S. Lim","doi":"10.1111/jocd.16746","DOIUrl":"10.1111/jocd.16746","url":null,"abstract":"&lt;p&gt;We recently published a manuscript entitled “Complications of Subcision for Acne Scarring: Experience From Clinical Practice and Review of the Literature.” This article describes the various methodologies and instrumentations employed in subcision including the use of hypodermic needles, Nokor needles, cannulas, blunt blades, cataract blades, throught to repurposed dove tail Toledo cannulas and novel sharp-edged instruments such as the Taylor Liberator.&lt;/p&gt;&lt;p&gt;Different techniques have been described in the literature, ranging from the conservative localized undermining of focal areas, triangulation using longer instruments, and modification of hypodermic needles, through to aggressive field undermining in conjunction with energy devices. There are limited studies on the efficacy and side effects of different techniques due to the polymorphic nature of acne scarring in addition to a lack of standardized execution of the procedure itself. Most studies are multimodality treatments that reflect the variation of scar signatures seen in acne scar patients [&lt;span&gt;1&lt;/span&gt;].&lt;/p&gt;&lt;p&gt;Whilst some authors propose restricting the length of instrumentation to minimize collateral damage to retaining ligaments, others recommend employing longer flexible instruments alongside a more conservative approach to mitigate side effects at entry points. Despite initial studies showing positive outcomes with sharp needle instruments, recent research indicates that longer and broader instruments, rather than hypodermic needles, yield better results whilst minimizing operating times [&lt;span&gt;2&lt;/span&gt;].&lt;/p&gt;&lt;p&gt;The plane of subcision has been largely agreed upon, namely the hypodermis; however, there is no consensus regarding the extent of undermining of the scar field. With “point subcision” using hypodermic needles, scars are released within a short distance of the chosen instrumentation. In comparison, longer instruments with wide dissecting heads (Taylor Liberators, blunt dissectors, and Toledo cannula) are more efficient at transection of scar tissue, with the drawback of collateral damage to normal tissue between scar areas. Over the past few years, there has been a trend to employ these described instruments as they require significantly less treatment time coupled with superior outcomes [&lt;span&gt;2-4&lt;/span&gt;].&lt;/p&gt;&lt;p&gt;Side effects such as hematomas, fibroplasia, post-inflammatory hyperpigmentation, entry site scarring, and paresthesia have been documented in the literature [&lt;span&gt;5&lt;/span&gt;], however In the past 2 years, I have observed two complications referred from other clinics that have been infrequently reported. Although not solely linked to a single instrument, these issues are more frequently associated with the use of a broad-based W-tip tool known as the Taylor Liberator. Most frequently, these side effects have occurred after a single aggressive treatment session.&lt;/p&gt;&lt;p&gt;Firstly, there is the phenomenon of persistent facial swelling lasting (defined by duration grea","PeriodicalId":15546,"journal":{"name":"Journal of Cosmetic Dermatology","volume":"24 1","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-01-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jocd.16746","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142931984","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Randomized, Double-Blind, Placebo-Controlled Study to Evaluate the Safety and Efficacy of a Nutraceutical Supplement With Standardized Botanicals in Males With Thinning Hair","authors":"Neal Bhatia,&nbsp;Glynis Ablon,&nbsp;Patricia K. Farris,&nbsp;Adina Hazan,&nbsp;Isabelle Raymond","doi":"10.1111/jocd.16778","DOIUrl":"10.1111/jocd.16778","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Hair thinning in men is a prevalent issue for which treatment oftentimes consists of a multi-modal approach. Targeting key root causes of hair thinning, such as hormones, stress, and metabolism through vitamins, minerals, and botanicals, has been shown to be effective in improving hair growth and quality in women. This approach could also be effective in improving hair growth and quality in men with thinning hair.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Aims</h3>\u0000 \u0000 <p>This study investigates the safety and efficacy of a nutraceutical in improving hair growth and quality in men with thinning hair.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>This was a 6-month multi-center, double-blind, randomized, placebo-controlled trial. Men aged 21–61 years old with confirmed hair thinning were included. Subjects were randomized to receive the oral supplement or placebo. The study end points included changes in blinded Global Investigator Ratings for hair growth and quality, the Men's Hair Growth Questionnaire (MHGQ), and changes in the Arizona Sexual Experience Scale (ASEX) in the active group compared to baseline and placebo.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Daily intake of the nutraceutical resulted in significantly more subjects in the active group compared to the placebo rated as improved for hair growth and quality in the blinded investigator global assessments. Overall changes and responses to the MHGQ also corroborated blinded investigator ratings. There were no trends in either treatment group for changes in sexual function on the ASEX questionnaire, and the supplement was well tolerated.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Ingestion of a nutraceutical targeting key root causes of male hair thinning significantly improves hair growth and quality in men with no changes in sexual function.</p>\u0000 </section>\u0000 </div>","PeriodicalId":15546,"journal":{"name":"Journal of Cosmetic Dermatology","volume":"24 1","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-01-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11701407/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142931917","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Relationships Between Quality of Life and Emotional Resilience for Those With and Without Acne","authors":"Caroline J. Stone,&nbsp;Nicole Ufkes,&nbsp;Aaron M. Secrest,&nbsp;Maureen A. Murtaugh,&nbsp;Megan E. Vanneman,&nbsp;Ashley M. Snyder","doi":"10.1111/jocd.16744","DOIUrl":"10.1111/jocd.16744","url":null,"abstract":"&lt;p&gt;Although not life-threatening or physically debilitating, acne vulgaris has a greater psychological impact than many other chronic conditions [&lt;span&gt;1&lt;/span&gt;]. Compared with patients with asthma, epilepsy, back pain, arthritis, or psoriasis, patients with acne experience similar, if not greater, impairment in mental health scores [&lt;span&gt;1&lt;/span&gt;]. Resilience helps maintain mental health in vulnerable populations undergoing stressors [&lt;span&gt;2&lt;/span&gt;]. Despite extensive research on mental health and acne, there is a notable lack of data exploring the connection between skin-related quality of life (SRQL) and emotional resilience in patients with acne.&lt;/p&gt;&lt;p&gt;Resilience, the ability to adapt to stress and adversity [&lt;span&gt;2&lt;/span&gt;], is essential for maintaining mental health. Emotional resilience can mitigate the psychological impact of stressors, leading to better mental health outcomes and improved satisfaction with clinical care [&lt;span&gt;2&lt;/span&gt;]. This exploratory study aimed to address how emotional resilience, measured using the Connor–Davidson Resilience Scale (CD-RISC), correlates with SRQL, measured using the Skindex-16, in patients with acne versus acne-free controls.&lt;/p&gt;&lt;p&gt;The Skindex-16 is a validated patient-reported outcome measure that assesses the effects of skin disease on quality of life across three domains: physical symptoms like itching and irritation, emotional responses such as worry or embarrassment, and functional impacts including difficulties with social interactions and work [&lt;span&gt;3&lt;/span&gt;]. We used data from a previously published project on acne and lifestyle among adolescents and young adults [&lt;span&gt;4&lt;/span&gt;]. Individuals between the ages of 12 and 24 years, with and without acne were included. Controls were excluded if they ever used isotretinoin and/or if they had a chronic inflammatory skin disease flaring at their dermatology visit. For both cases and controls, female participants could not be pregnant or breastfeeding or ever have been diagnosed with polycystic ovary syndrome. Only participants with complete data were included, resulting in a sample of 195 participants, with an average age of 18.7 years and ranging from 12 to 24 years. Most participants were female (&lt;i&gt;n&lt;/i&gt; = 120 [61.5%]) and non-Hispanic White (&lt;i&gt;n&lt;/i&gt; = 159 [81.5%]) (Table 1). Most participants had left secondary education and were attending college or trade school after high school (&lt;i&gt;n&lt;/i&gt; = 76 [39.0%]), were attending graduate school (&lt;i&gt;n&lt;/i&gt; = 11 [5.6%]), or had left school entirely (&lt;i&gt;n&lt;/i&gt; = 27 [13.8%]). The rest were in middle school (&lt;i&gt;n&lt;/i&gt; = 24 [12.3%]) or high school (&lt;i&gt;n&lt;/i&gt; = 57 [29.2%]). Forty-seven (24.1%) had full-time employment, 68 (34.9%) worked part-time jobs, and 2 (1.0%) had both full-time and part-time jobs. Among acne cases, severity ranged from almost clear to severe. Skindex-16 instructions (but not questions) were modified to ask participants to reflect specifically on their acne or other skin condition.&lt;/p&gt;&lt;p&gt;","PeriodicalId":15546,"journal":{"name":"Journal of Cosmetic Dermatology","volume":"24 1","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-01-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11701875/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142931962","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Case Report: Management of Polycaprolactone-Based Dermal Filler–Induced Vascular Occlusion","authors":"Shirin Zaresharifi,&nbsp;Mehdi Gheisari,&nbsp;Hamideh Mohammadzadeh,&nbsp;Hojjat Layegh,&nbsp;Maliheh Amani","doi":"10.1111/jocd.16779","DOIUrl":"10.1111/jocd.16779","url":null,"abstract":"&lt;p&gt;A 42-year-old female presented to the clinic 3 days after receiving polycaprolactone (PCL)-based dermal filler injections in the hypodermal layer of nasolabial folds by the use of a needle. She had received 0.5 cc of PCL-based filler in each nasolabial fold under local anesthesia. She did not mention any pain during the injection. However, she noticed erythema and pain in the left nasolabial fold 1 day after the procedure, which she did not find significant and did not seek medical care for it; however, as the symptoms progressively worsened despite initial conservative management with over-the-counter analgesics she visited our clinic (Figure 1).&lt;/p&gt;&lt;p&gt;Her medical history was unremarkable, and she did not report any prior history of dermal filler injection in this area. The filler injection had been performed without immediate adverse events. Physical examination revealed erythema, tenderness, and moderate edema along the left nasolabial fold; there were also areas of dusky erythema and pustule formation indicating impending necrosis in the area. Her physical examination was otherwise unremarkable.&lt;/p&gt;&lt;p&gt;After 5 months of follow-up, the patient healed with minimal scarring and an excellent cosmetic outcome.&lt;/p&gt;&lt;p&gt;PCL-based fillers are generally considered safe for soft tissue augmentation due to their biocompatibility and longevity. However, as demonstrated in this case, vascular occlusion remains a significant risk associated with all dermal fillers, particularly in areas such as the nasolabial folds, where major arteries are present [&lt;span&gt;1&lt;/span&gt;]. Vascular occlusion can occur due to direct injection into a vessel, or external compression of nearby vasculature by the filler material and inflammation. This can lead to ischemia and, if untreated, tissue necrosis and significant scarring [&lt;span&gt;2&lt;/span&gt;].&lt;/p&gt;&lt;p&gt;Anatomical factors play a pivotal role in the occurrence of such complications. The facial artery, which arises from the external carotid artery, follows a tortuous course across the face, making it highly susceptible to inadvertent cannulation or compression. In the nasolabial fold, the facial artery and its branches, particularly the superior labial and angular arteries, lie close to typical filler injection planes within the dermis or hypodermis. The variable depth and tortuosity of the facial artery further complicate this risk. While in most individuals, it runs deeply in the lower two-thirds of the nasolabial fold before becoming more superficial in the upper one-third, in some patients, it may course superficially, lying within millimeters of the dermis even in the lower part, or it may be situated deeply at the alar base. This variability can lead to unpredictable outcomes, even when standard injection techniques are employed [&lt;span&gt;3&lt;/span&gt;].&lt;/p&gt;&lt;p&gt;Furthermore, areas such as the glabella and the periorbital regions are considered “high-risk zones” due to the presence of critical anastomoses between the facial and ophthalmic a","PeriodicalId":15546,"journal":{"name":"Journal of Cosmetic Dermatology","volume":"24 1","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-01-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jocd.16779","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142931969","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Epigenetic Modifications and the Role of Medical Lasers in Enhancing Skin Regeneration","authors":"Diala Haykal,&nbsp;François Will,&nbsp;Hugues Cartier,&nbsp;Serge Dahan","doi":"10.1111/jocd.16780","DOIUrl":"10.1111/jocd.16780","url":null,"abstract":"&lt;p&gt;As the demand for innovative and effective skin treatments grows, the field of dermatology continues to evolve, integrating cutting-edge technologies with new biological insights. Among the most impactful advances in recent years are medical laser therapies, widely used to treat skin. While the immediate effects of laser treatments are well-documented, research has begun to reveal that their benefits go deeper, potentially triggering long-lasting changes at the molecular level. At the heart of this molecular transformation is epigenetics, focusing on changes in gene expression that do not alter the underlying DNA sequence. Unlike permanent genetic mutations, epigenetic changes can be reversible and are heavily influenced by environmental and external factors, including therapeutic interventions like laser treatments. Epigenetic mechanisms, such as DNA methylation, histone modification, and non-coding RNA regulation, control many of the key biological processes involved in skin health, aging, and repair [&lt;span&gt;1, 2&lt;/span&gt;]. Recent research suggests that medical lasers induce epigenetic modifications that enhance skin regeneration and repair, offering longer lasting results than previously understood [&lt;span&gt;3&lt;/span&gt;]. This commentary aims to explore how lasers trigger long-lasting regenerative effects through epigenetic mechanisms and how this knowledge could shape future advancements in dermatological care [&lt;span&gt;4&lt;/span&gt;]. By understanding how lasers can tap into these epigenetic pathways, we open the door to more personalized and effective skin treatments that go beyond superficial improvements.&lt;/p&gt;&lt;p&gt;The concept of epigenetics has revolutionized our understanding of how gene expression is modulated by external influences, including environmental exposure, stress, and injury. Unlike genetic mutations, epigenetic changes leave the DNA sequence intact but modify the way genes are expressed. These changes are reversible, offering a tantalizing avenue for therapeutic interventions in dermatology. In skin biology, epigenetic mechanisms play a critical role in processes like wound healing, inflammation, and aging [&lt;span&gt;5&lt;/span&gt;]. Studies have shown that aging skin is associated with increased DNA methylation, which silences genes involved in collagen production and skin elasticity. Histone modifications, another key epigenetic mechanism, regulate the accessibility of chromatin, the structural framework of DNA, influencing gene transcription [&lt;span&gt;3, 6&lt;/span&gt;]. In aging skin, histone acetylation and methylation patterns become dysregulated, contributing to reduced cellular repair and regeneration. Non-coding RNAs, particularly microRNAs (miRNAs), have also emerged as important players in skin health. These small RNA molecules regulate gene expression at the post-transcriptional level by binding to messenger RNAs (mRNAs) and preventing their translation into proteins. Specific miRNAs have been linked to the regulation of inflammation, collagen synt","PeriodicalId":15546,"journal":{"name":"Journal of Cosmetic Dermatology","volume":"24 1","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-01-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jocd.16780","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142931973","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Embracing New Love: Why Customers Are Loyal to Plant Extract-Based Skin-Care Cosmetics","authors":"I-Hsuan Wu,&nbsp;Chaoyun Liang","doi":"10.1111/jocd.16731","DOIUrl":"10.1111/jocd.16731","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>In recent years, increases in consumer awareness regarding health and the environment have enhanced their willingness to purchase plant extract-based skin-care products. Although the skin-care product industry has paid increasing attention to consumer behavior in recent years, few studies have investigated customer loyalty to this type of product; in-depth research is urgently required to fill this gap.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Aims</h3>\u0000 \u0000 <p>This study investigated Taiwanese skin-care products derived from plant extracts by identifying the relationships between consumer prior experience, involvement, perceived value, and loyalty. It also examined how demographic characteristics influence consumer loyalty.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Patients/Methods</h3>\u0000 \u0000 <p>An online survey yielded 920 valid samples for statistical analysis. Three constructs of involvement, namely product, message, and situational involvement; three constructs of perceived value, namely functional, emotional, and social value; and three constructs of consumer loyalty, namely repurchase intention, willingness to receive information, and willingness to pay, were identified through factor analysis.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>The respondents' perceived value significantly influenced their loyalty toward Taiwanese plant-extract-based skin-care products. The factor with the strongest effect on repurchase intention was emotional value, followed by functional value, product involvement, and social value. The factor with the strongest influence on willingness to receive information and willingness to pay was functional value, followed by product involvement, situational involvement, and emotional value.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Respondents with higher educational levels were less likely to repurchase and less willing to receive information on plant extract-based skin-care products. Moreover, men were more willing to pay price premiums for these products than were women.</p>\u0000 </section>\u0000 </div>","PeriodicalId":15546,"journal":{"name":"Journal of Cosmetic Dermatology","volume":"24 1","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-01-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11699509/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142927312","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Genetic Causal Association Between Skin Microbiota and Biological Aging: Evidence From a Mendelian Randomization Analysis","authors":"Yuan Li,&nbsp;Liwen Ma,&nbsp;Lipan Fan,&nbsp;Chuyan Wu,&nbsp;Dan Luo,&nbsp;Feng Jiang","doi":"10.1111/jocd.16762","DOIUrl":"10.1111/jocd.16762","url":null,"abstract":"&lt;div&gt;\u0000 \u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Background&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;The skin microbiota, a complex community of microorganisms residing on the skin, plays a crucial role in maintaining skin health and overall homeostasis. Recent research has suggested that alterations in the composition and function of the skin microbiota may influence the aging process. However, the causal relationships between specific skin microbiota and biological aging remain unclear. Mendelian randomization (MR) analysis provides a powerful tool to explore these causal links by utilizing genetic variants as instrumental variables, thereby minimizing confounding factors and reverse causality that often complicate observational studies.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Methods&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;We utilized a two-sample MR approach with population-based cross-sectional data from two German cohorts, KORA FF4 (&lt;i&gt;n&lt;/i&gt; = 324) and PopGen (&lt;i&gt;n&lt;/i&gt; = 273). In total, GWAS summary data from 1656 skin samples and datasets on accelerated biological age were analyzed to investigate the causal relationship between skin microbiota and accelerated biological aging. The primary analysis was performed using the inverse variance weighted (IVW) method with random effects and was further supported by MR-Egger regression, Cochran's &lt;i&gt;Q&lt;/i&gt; test, and a range of sensitivity analyses.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Results&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;The MR analysis revealed that for biological age acceleration (BioageAccel), the IVW analysis identified protective effects from certain skin microbiota, including Alphaproteobacteria_Dry (&lt;i&gt;p&lt;/i&gt; = 0.046), Asv033_sebaceous (&lt;i&gt;p&lt;/i&gt; = 0.043), Burkholderiales_Moist (&lt;i&gt;p&lt;/i&gt; = 0.008), and Proteobacteria_Moist (&lt;i&gt;p&lt;/i&gt; = 0.042). Similar protective effects were observed for Burkholderiales_Moist (&lt;i&gt;p&lt;/i&gt; = 0.045) and Proteobacteria_Moist (&lt;i&gt;p&lt;/i&gt; = 0.012) in the weighted median analysis. In contrast, Paracoccus_Moist (&lt;i&gt;p&lt;/i&gt; = 0.013) and Proteobacteria_Sebaceous (&lt;i&gt;p&lt;/i&gt; = 0.005) were associated with accelerated aging. When using PhenoAge acceleration as the outcome, the IVW analysis linked skin microbiota like Asv005_Dry (&lt;i&gt;p&lt;/i&gt; = 0.026), ASV039_Dry (&lt;i&gt;p&lt;/i&gt; = 0.003), Betaproteobacteria_Sebaceous (&lt;i&gt;p&lt;/i&gt; = 0.038), and Chryseobacterium_Moist (&lt;i&gt;p&lt;/i&gt; = 0.013) with accelerated aging. The weighted median analysis supported these findings and also identified protective effects from ASV011_Dry (&lt;i&gt;p&lt;/i&gt; = 0.021), ASV023_Dry (&lt;i&gt;p&lt;/i&gt; = 0.040), Bacteroidales_Dry (&lt;i&gt;p&lt;/i&gt; = 0.022), Enhydrobacter_Moist (&lt;i&gt;p&lt;/i&gt; = 0.038), Proteobacteria_Moist (&lt;i&gt;p&lt;/i&gt; = 0.002), and Rothia_Moist (&lt;i&gt;p&lt;/i&gt; = 0.038).&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Conclusion","PeriodicalId":15546,"journal":{"name":"Journal of Cosmetic Dermatology","volume":"24 1","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-01-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11699445/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142927314","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Intradermal Incobotulinum Toxin A for Postbreast Cancer Treatment Asymmetry: A Literature Review and Case Report","authors":"Alejandra Bugallo,&nbsp;Luis Alberto Parra,&nbsp;Andreina Martinez Amado,&nbsp;Victoria De la Fuente,&nbsp;Evalicia Murúa,&nbsp;Eliana Garcés,&nbsp;Andrea Marcela Parra","doi":"10.1111/jocd.16754","DOIUrl":"10.1111/jocd.16754","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Botulinum toxin (BTX) is globally the most common aesthetic procedure. Its usage has expanded beyond facial treatments to therapeutic areas, including managing scars and postsurgical deformities. Breast cancer survivors often face significant deformities and asymmetry during recovery.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Objectives</h3>\u0000 \u0000 <p>This study systematically reviewed literature from the past 4 years on botulinum toxin applications in breast cancer survivors and presented a case report of a patient treated with Incobotulinum toxin (IncoBonTA; Xeomin, Merz Pharmaceuticals GmbH, Frankfurt, Germany) for left breast deformity postchemotherapy and radiotherapy.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Following PRISMA guidelines, a systematic search was conducted on PubMed and Scopus using keywords: “botulinum toxin,” “breast cancer,” and “breast asymmetry,” identifying relevant literature from 2020 to 2024. Five full-text articles were included. Additionally, a 2024 case report of a patient with significant breast asymmetry postsurgery and radiotherapy was published.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>The literature review indicated botulinum toxin's primary uses in breast cancer include pain management, upper limb impairment, postsurgical scars, and capsular contracture. Although some benefits were reported, further research is needed. In the case report, the patient was treated in one session with IncoBonTA at two different dilutions based on contracture severity without complications.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>The review showed promising advances in using botulinum toxin for deformities secondary to oncological treatment in breast cancer patients. The therapy was administered to a 53-year-old patient, resulting in significant aesthetic improvement, especially at the nipple and areola, suggesting that it was a viable option for these patients.</p>\u0000 </section>\u0000 </div>","PeriodicalId":15546,"journal":{"name":"Journal of Cosmetic Dermatology","volume":"24 1","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-01-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11699508/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142927318","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evolution of Pathogenesis and Trends in the Treatment of Melasma in Last Two Decades","authors":"Rashmi Sarkar,&nbsp;Aanchal Bansal,&nbsp;Michael Gold","doi":"10.1111/jocd.16758","DOIUrl":"10.1111/jocd.16758","url":null,"abstract":"&lt;p&gt;Melasma is a common relapsing pigmentary disorder that presents with symmetrically patterned hyperpigmented patches in the photo-exposed regions of the face such as the centro-facial, malar, and mandibular region. The first introduction of the disease was described in 1910. For decades, there has been a change in understanding of the etiopathogenesis and evolution of treatment in melasma. Syder and Elbuluk [&lt;span&gt;1&lt;/span&gt;] reviewed and summarized the history of melasma from its origin till the early 2000s and described that melasma is a multifactorial disease with a phenotypic presentation related to the interplay of genetic predisposition, oxidative stress, hormonal factors and light exposure. Further development and research in the past decade have elucidated other pathogenetic mechanisms.&lt;/p&gt;&lt;p&gt;The genetic origin has been described with an increased predisposition of the disease by 41%–61% in first-degree relatives, as compared to 16%–28% in the normal population, in a Brazilian study [&lt;span&gt;2&lt;/span&gt;]. It has been recently found to follow an autosomal dominant inheritance pattern. The presence of senescent fibroblasts in melasma skin leads to increased release of inflammatory and melanogenic factors. Esposito et al. [&lt;span&gt;3&lt;/span&gt;] found lower cell density, altered morphology, higher amount of cytoplasmic senescence-β-galactosidase with altered expression of genes in fibroblasts of melasma skin as compared to normal photo-exposed regions. The most important factors attributed to melasma development and aggravation are unsatisfactory use of sunscreens, incomplete blockage from solar radiations involved in melanogenesis including ultraviolet A and B rays, visible light and association with cooking heat and occupational exposure [&lt;span&gt;4&lt;/span&gt;]. Recent literature talks about molecular signs of oxidative stress such as increased expression of p38 protein kinase in the upper dermis in response to various stimuli, such as stress, inflammatory cytokines, ultraviolet rays, heat, and osmotic shock [&lt;span&gt;5&lt;/span&gt;].&lt;/p&gt;&lt;p&gt;The development of pathological understanding has broadened the therapeutic options over recent years and treatment can be tailored according to individualistic requirements.&lt;/p&gt;&lt;p&gt;A review of recent trends in the treatment of melasma by Zheng et al. [&lt;span&gt;6&lt;/span&gt;] in this journal highlighted the centrality of topical treatments like hydroquinone in combination with tretinoin and topical corticosteroids as triple combination creams in the early 2000s. Other topical agents like azelaic acid, glycolic acid and retinoic acid were also frequently used for their exfoliating and depigmenting properties. The early decade highlighted an enormous trend of chemical peel treatment with glycolic acid peels (20%–70%) and trichloroacetic acid peels to treat epidermal melasma (Figure 1). Peels were often recommended as a second-line therapy, especially for patients who did not respond to topical treatments [&lt;span&gt;7&lt;/span&gt;]. However, in the mid","PeriodicalId":15546,"journal":{"name":"Journal of Cosmetic Dermatology","volume":"24 1","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-01-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11694332/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142914433","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}