Journal of Cosmetic Dermatology最新文献

{"title":"Targeting Circadian Rhythm for the Regulation of Skin Collagen Metabolism","authors":"Cheng Wang,&nbsp;Tianlin Song,&nbsp;Yurong Zhang,&nbsp;Nihong Li,&nbsp;Ling Xie,&nbsp;Min Xie,&nbsp;Xingwu Jiang,&nbsp;Guanglei Lü,&nbsp;Yun Meng,&nbsp;Chaochao Wang,&nbsp;Lijun Yue,&nbsp;Wei Yang,&nbsp;Yang Li,&nbsp;Yelin Wu,&nbsp;Liang Chen","doi":"10.1111/jocd.70638","DOIUrl":"10.1111/jocd.70638","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Collagen is essential for maintaining skin structure and function, and the circadian rhythm is known to regulate a wide range of physiological processes.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Aims</h3>\u0000 \u0000 <p>To investigate whether collagen metabolism in human skin fibroblasts exhibits circadian regulation, and to evaluate whether the time-coordinated application of baicalin at daytime and palmitoyl tripeptide-1 (PT-1) at nighttime synergistically promotes collagen fiber formation and improves overall skin quality.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>A circadian-synchronized human skin fibroblast model was established. The expression of collagen metabolism-related genes was analyzed using qPCR and immunofluorescence. Subsequently, an 8-week topical application study was conducted in mice using a regimen of daytime baicalin and nighttime PT-1. Finally, a clinical trial involving 30 female participants was conducted, employing the same time-coordinated application scheme.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Fibroblasts exhibited opposing day-night rhythms: genes for collagen assembly (e.g., LOX) peaked during the day, while those involved in synthesis/secretion (e.g., Sec61a2, Mia3, Pde4d, Vps33b) and degradation (e.g., CTSK, MMP1) peaked at night. Time phase-dependent interventions showed baicalin enhanced daytime assembly, while PT-1 boosted nighttime synthesis. In mice, a timed day-night combination therapy increased collagen fiber density. Clinical trial (<i>n</i> = 30) confirmed the efficacy, showing significant improvements in skin luminance (+16.29%), nasolabial fold depth (−36.35%), and firmness (R2: +24.35%).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Collagen metabolism is regulated by circadian rhythms. Chronomodulated baicalin and PT-1 application synergistically optimize collagen metabolism and improve skin quality.</p>\u0000 </section>\u0000 </div>","PeriodicalId":15546,"journal":{"name":"Journal of Cosmetic Dermatology","volume":"25 1","pages":""},"PeriodicalIF":2.5,"publicationDate":"2026-01-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12797011/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145959557","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Energy-Based Devices for the Treatment of Cutaneous Lesions in Patients With Lupus Erythematosus and Dermatomyositis","authors":"Hae Chang Joh,&nbsp;Mihn-Sook Jue,&nbsp;Joo Yeon Ko","doi":"10.1111/jocd.70642","DOIUrl":"10.1111/jocd.70642","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>The use of energy-based devices (EBDs) for aesthetic and dermatological conditions is increasing, but data on efficacy and safety in autoimmune connective tissue disease (CTD) patients remain limited.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Objectives</h3>\u0000 \u0000 <p>This study assesses EBD real-world treatment outcomes in Korean patients with lupus erythematosus (LE) and dermatomyositis (DM).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>A retrospective, uncontrolled study was conducted on 26 CTD patients (LE: 20, DM: 6) treated at Hanyang University Seoul Hospital (2015–2023). Various laser modalities, including pulsed-dye laser (PDL), intense pulsed light (IPL), long-pulse Nd:YAG (LPNY), Q-switched Nd:YAG (QSNY), and ablative fractional laser (AFL), were analyzed. Two independent dermatologists evaluated treatment outcomes using a 5-point modified Investigator's Global Assessment (IGA) scale.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Patients showed significant improvement in erythema, dyspigmentation, and overall skin morphology. Some LE patients also exhibited enhanced follicular activity. Treatments were well-tolerated, with only transient side effects reported, and no long-term complications or disease reactivation occurred.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>EBD treatments may provide cosmetic improvement in selected LE and DM patients and are generally safe. Larger controlled studies are needed to confirm efficacy and establish optimal protocols.</p>\u0000 </section>\u0000 </div>","PeriodicalId":15546,"journal":{"name":"Journal of Cosmetic Dermatology","volume":"25 1","pages":""},"PeriodicalIF":2.5,"publicationDate":"2026-01-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12793946/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145952016","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Fear of Overfilling (FOF): A Clinically Significant Response to Digital Aesthetics and the Dermatologist's Imperative to Preserve Facial Identity","authors":"Rafael Rodrigo Crisanto de Oliveira","doi":"10.1111/jocd.70652","DOIUrl":"10.1111/jocd.70652","url":null,"abstract":"&lt;p&gt;Hyaluronic acid (HA) fillers remain the cornerstone of contemporary aesthetic dermatology, offering reversibility, predictable outcomes, and the capacity to rejuvenate while maintaining core facial identity when anatomically guided [&lt;span&gt;1, 2&lt;/span&gt;]. Alongside the evolution in technique and safety, a parallel sociocultural transformation driven by digital aesthetics has reshaped public perception of fillers. Within this landscape, two interconnected phenomena have emerged as central to modern clinical practice: Overfilled Face Syndrome (OFS) and its psychological counterpart, the Fear of Overfilling (FOF). This commentary proposes FOF as a conceptual framework and heuristic tool rather than a formally validated diagnostic entity, serving to understand a clinically significant response to the hypervisibility of distorted aesthetic outcomes in digital environments. Recognizing FOF as a structured psychocultural phenomenon is essential for improving communication, enhancing adherence, and guiding modern treatment planning.&lt;/p&gt;&lt;p&gt;FOF is conceptualized as a psychologically and culturally mediated fear of identity disruption, not merely of poor aesthetic results. It is crucial to distinguish this construct from Body Dysmorphic Disorder (BDD), which is characterized by a pathological internal distortion of self-perception and an obsessive pursuit of correction for non-existent or slight physical defects [&lt;span&gt;3&lt;/span&gt;]. While BDD involves a persistent preoccupation with perceived flaws, FOF represents a rational, anticipatory concern regarding iatrogenic identity loss—the fear of “losing one's self” through clinical intervention. Furthermore, FOF is distinct from general procedural anxiety; while the latter is a physiological or psychological response to the medical act itself, FOF focuses specifically on the long-term aesthetic and psychosocial consequences of over-augmentation and the disruption of facial coherence. By articulating FOF as a distinct conceptual clinical construct, dermatologists are positioned as guardians of identity coherence amid an environment where unnatural aesthetic outcomes are simultaneously normalized and feared.&lt;/p&gt;&lt;p&gt;Modern patients frequently express concerns about looking “overdone” or “artificial,” worries heightened by the saturation of exaggerated outcomes on social media platforms [&lt;span&gt;4, 5&lt;/span&gt;]. Digital filters, portrait-mode elongation, and reshaping algorithms have collectively shifted internal norms of facial proportions. Although these tools promote idealized images, they paradoxically reinforce fear toward aesthetic procedures.&lt;/p&gt;&lt;p&gt;In this context, FOF emerges primarily as a fear of identity loss, representing a fundamental shift in patient psychology: Aesthetic decisions are increasingly based not only on traditional risk–benefit considerations but on the perceived threat to personal recognizability. This shift is further intensified by the paradox of enhancement: Progressive modifications—either t","PeriodicalId":15546,"journal":{"name":"Journal of Cosmetic Dermatology","volume":"25 1","pages":""},"PeriodicalIF":2.5,"publicationDate":"2026-01-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12794127/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145952096","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Topical Carboxytherapy Modulates the Skin Microbiome Following CO2 Laser Resurfacing: A Pilot Study","authors":"Barbara Hernandez-Rovira,&nbsp;Emma Villamaria,&nbsp;Julia Oh,&nbsp;Bengisu Ozarslan,&nbsp;Saranya Wyles","doi":"10.1111/jocd.70668","DOIUrl":"10.1111/jocd.70668","url":null,"abstract":"&lt;p&gt;Skin microbiome contributes to cutaneous homeostasis and barrier defense by regulating keratinocyte proliferation, angiogenesis, and immune responses [&lt;span&gt;1, 2&lt;/span&gt;]. Carbon dioxide (CO&lt;sub&gt;2&lt;/sub&gt;) laser resurfacing, widely used for photoaging and scar revision, induces controlled dermal injury and transient skin barrier disruption to trigger the wound healing cascade. Topical carboxytherapy, which delivers CO&lt;sub&gt;2&lt;/sub&gt; transdermally, is proposed to enhance tissue regeneration by improving oxygenation and microvascular perfusion [&lt;span&gt;3&lt;/span&gt;]; however, its mechanistic impact on skin physiology and microbial communities remains poorly defined. Given the role of skin microbiota in wound healing and inflammation, understanding how these procedures affect microbial dynamics is clinically relevant. This pilot study aimed to characterize the facial skin microbiome following full-face CO&lt;sub&gt;2&lt;/sub&gt; fractional resurfacing and post-procedural treatment with topical carboxytherapy (CO&lt;sub&gt;2&lt;/sub&gt; Lift, Lumisque, Weston, FL).&lt;/p&gt;&lt;p&gt;Two participants were enrolled and assigned to one of two post-laser care groups: the placebo group (&lt;i&gt;n&lt;/i&gt; = 1) received standard care with a petroleum-based ointment, while the intervention group (&lt;i&gt;n&lt;/i&gt; = 1) was treated with a gel-formulated carboxytherapy. VISIA-CR (Canfield Scientific Inc., Parsippany, NJ) imaging was performed at baseline and 12 weeks post-procedure (Figure 1). Microbiome samples were collected from the left versus right malar cheek at baseline and week 4 using standardized swabbing. Microbial profiling was performed via 16S rRNA gene sequencing with genus-level taxonomic assignment; sequencing depth and diversity metrics were evaluated descriptively, without statistical testing, due to the limited sample size. Genus-level taxonomic composition is shown in Figure 2. Given that only one participant was included per group, this exploratory pilot study was not powered for statistical comparison between groups, and all findings are presented as hypothesis-generating observations without inference of group differences or treatment effects.&lt;/p&gt;&lt;p&gt;&lt;i&gt;Cutibacterium&lt;/i&gt; spp. was the dominant genus across all subjects, with bilateral detection at both time points. Relative abundance increased from 79% at baseline to 92% at week 4. &lt;i&gt;Corynebacterium&lt;/i&gt; spp. was the second most abundant genus (11% at baseline, 3% at week 4), followed by low-abundance taxa including &lt;i&gt;Streptococcus&lt;/i&gt; spp. and &lt;i&gt;Staphylococcus&lt;/i&gt; spp. Alpha diversity patterns varied between participants at baseline and over time; both groups exhibited a slight decline. These findings are reported descriptively only. Beta diversity analysis suggested overall compositional stability within individuals between baseline and follow-up, though no formal clustering or between-group comparisons can be inferred.&lt;/p&gt;&lt;p&gt;An observed increase in the relative abundance of &lt;i&gt;Cutibacterium&lt;/i&gt; spp., presumed to be &lt;i&gt;C. acnes&lt;/i&gt;, following CO&lt;","PeriodicalId":15546,"journal":{"name":"Journal of Cosmetic Dermatology","volume":"25 1","pages":""},"PeriodicalIF":2.5,"publicationDate":"2026-01-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12793962/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145952103","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Rising Public Interest in Weight Loss Medications and Growing Awareness of Their Aesthetic Sequelae: An Infodemiologic Google Trends Analysis and Clinical Diagnostic Patterning","authors":"Alec D. McCarthy,&nbsp;Kay Durairaj,&nbsp;Jacob Linneman-Heath,&nbsp;Dusan Sajic,&nbsp;Mara Dacso,&nbsp;Alan Durkin","doi":"10.1111/jocd.70670","DOIUrl":"10.1111/jocd.70670","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Glucagon-like peptide-1 receptor agonists (GLP-1 RAs) have gained rapid popularity for both medical and consumer-directed weight loss. This growth has been accompanied by increased public discussion regarding facial aesthetic changes, commonly referred to as “Ozempic face,” characterized by volume depletion and cutaneous laxity.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>To quantify temporal patterns of public search interest in a widely known GLP-1 RA and evaluate corresponding awareness of its cosmetic facial sequelae using infodemiologic methods.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Google Trends data for “Ozempic” and related frequently co-searched queries were analyzed from November 2021 to December 2024. Trends in relative search volume (RSV) were examined, with particular focus on terms associated with facial aesthetics, including “Ozempic face” and “plastic surgeons Ozempic face.”</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>RSV for “Ozempic” showed a steady upward trajectory over the study period. Queries related to facial aesthetic consequences exhibited substantial proportional increases. Notably, “Ozempic face” demonstrated a 4600% rise in RSV, and searches for “plastic surgeons Ozempic face” similarly grew markedly.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Public interest in GLP-1 RAs is strongly associated with rising awareness and concern about their facial aesthetic effects. These trends suggest that aesthetic practitioners should expect more patient inquiries regarding GLP-1–related facial changes and should proactively integrate counseling and corrective treatment options into clinical practice.</p>\u0000 </section>\u0000 </div>","PeriodicalId":15546,"journal":{"name":"Journal of Cosmetic Dermatology","volume":"25 1","pages":""},"PeriodicalIF":2.5,"publicationDate":"2026-01-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12793942/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145952026","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Menopause and Dermal White Adipose Tissue Depletion: Mechanistic Links, Adipogenesis, and Regenerative Therapeutic Replacement","authors":"Alan D. Widgerow,&nbsp;Mary E. Ziegler,&nbsp;Faiza Shafiq","doi":"10.1111/jocd.70671","DOIUrl":"10.1111/jocd.70671","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Menopause is linked to typical skin changes such as textural alterations, loss of skin hydration, elasticity, thinning, and increased fragility. Dermal white adipose tissue (dWAT), a distinct fat component located in the dermis and involved in hair cycle regulation, antimicrobial peptide production, and extracellular matrix (ECM) modulation, decreases with aging and photodamage. Emerging evidence suggests that estrogen contributes to an inhibitory effect on dWAT and promotes fibrotic remodeling of adipose tissue of the dermis.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>To examine the mechanistic evidence linking menopause with the loss of dWAT and to suggest and highlight potential strategies for replacing dWAT with agents such as magnolol, which promote the conversion of pre-adipocytes to adipocytes and restore lost fractions of the dWAT compartment.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>A review of the literature, a mechanistic examination, a histologic examination, and a clinical trial assessment were conducted.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>The loss of dWAT and fibrotic replacement are likely a factor causally linked to the decrease in estrogen observed during menopause. Reduced dWAT produces fewer adipokines such as adiponectin, which is directly involved in skin health by promoting collagen and hyaluronic acid (HA) production. Evidence suggests that select non-hormonal agents can offer a potential therapeutic benefit to menopausal skin promoting dWAT restoration through adipogenic pathways.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>dWAT depletion likely contributes to menopausal skin changes. Potential candidates for non-hormonal alternatives to address these menopausal concerns are discussed in this paper.</p>\u0000 </section>\u0000 </div>","PeriodicalId":15546,"journal":{"name":"Journal of Cosmetic Dermatology","volume":"25 1","pages":""},"PeriodicalIF":2.5,"publicationDate":"2026-01-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12793821/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145952042","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reparative Effects of a Topical Antioxidant Serum Containing Vitamin C, Vitamin E, and Ferulic Acid After Ablative Fractional CO2 Laser Treatment for Atrophic Acne Scars: A Randomized, Investigator-Blinded, Split-Face, Controlled Trial","authors":"Yu Shi,&nbsp;Sijia Xu,&nbsp;Wei Zhang","doi":"10.1111/jocd.70634","DOIUrl":"10.1111/jocd.70634","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Ablative fractional CO₂ laser is effective for acne scar treatment but is often associated with side effects such as erythema and dyspigmentation, along with prolonged recovery time.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Aims</h3>\u0000 \u0000 <p>The study aimed to evaluate the post-procedure reparative effects of a combination of vitamin C, E, and ferulic acid (CE Ferulic) in Chinese patients with atrophic acne scars.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>In this randomized, investigator-blinded, split-face, controlled trial, patients aged 18–50 with moderate-to-severe atrophic acne scars were randomly assigned to apply CE Ferulic to intervention-side face and normal saline (NS) to control-side face, immediately after ablative CO₂ laser treatment for 14 days. Patients were further divided into once-daily and twice-daily application subgroups. During the 14-day follow-up, the wound healing (measured by scabbing stage on Day 7), erythema index (EI), melanin index (MI), skin hydration, and transepidermal water loss (TEWL) were evaluated. Direct assessment of scar improvement was not within the scope of this study.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Sixty-four patients were included in the analysis. On Day 7, the intervention side showed a higher complete scab detachment rate than the control side (60.9% vs. 34.4%, <i>p</i> = 0.0026). EI and MI reduced significantly greater on the intervention side compared to the control side (Days 3, 7, and 14; <i>p</i> &lt; 0.0001). On Day 14, the intervention side also demonstrated significantly better capability of maintaining skin hydration (<i>p</i> = 0.0367) and preventing TEWL (<i>p</i> = 0.0246) than the control side.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>This study found that CE Ferulic led to enhanced wound healing, reduced erythema and melanin levels, and improved skin hydration following laser treatment, suggesting its beneficial application in combination with laser treatment to accelerate skin recovery.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Trial Registration</h3>\u0000 \u0000 <p>ChiCTR2300078214</p>\u0000 </section>\u0000 </div>","PeriodicalId":15546,"journal":{"name":"Journal of Cosmetic Dermatology","volume":"25 1","pages":""},"PeriodicalIF":2.5,"publicationDate":"2026-01-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12793811/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145952069","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Facial Skin Revitalization With CPM-HA20G (Hyaluronic Acid + Glycerol): A Comparative Case Series Using Three Delivery Techniques With Ultrasound Confirmation","authors":"Kim Booysen,&nbsp;Frank Lin","doi":"10.1111/jocd.70660","DOIUrl":"10.1111/jocd.70660","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Skin boosters are commonly administered into the dermis or immediate subdermal plane using serial puncture technique. Alternative delivery methods, such as blunt cannulas and multiple-needle injector devices, are available, but their ability to achieve comparable clinical outcomes has been under-investigated. This case series presents the first prospective comparative evaluation of CPM-HA20G administered via three different modalities, assessing efficacy, safety, and adverse events, while utilizing ultrasound to confirm product placement. To minimize patient-related variability, a split-face study design was also employed.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>To demonstrate the efficacy, safety, and comparability of results when delivering CPM-HA20G via multiple modalities into the immediate subdermal plane.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Fifteen patients received three treatments of CPM-HA20G, four weeks apart, using serial puncture, blunt cannula, and multiple-needle injector device. A separate split-face case compared serial puncture with blunt cannula delivery in the same patient, with ultrasound confirmation of product placement. Satisfaction rates, pain scores, and skin quality were assessed at 4, 8, and 12 weeks.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>All 15 patients across the three modalities achieved comparable improvements in skin elasticity, firmness, and hydration. High patient satisfaction was reported, with no serious adverse effects observed. A paired <i>t</i>-test showed pain scores were significantly lower with blunt cannula (mean 2.2) compared with serial puncture (mean 4.6) and injector device (mean 4.5) (<b><i>p</i> &lt; 0.0001</b>). Blunt cannula delivery was also associated with a lower incidence of bruising, suggesting clinical advantages for patient comfort and recovery.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>This case series demonstrates that serial puncture technique, blunt cannula and multiple-needle injector device can be used to deliver safe, comparable, and effective CPM-HA20G treatments. These findings highlight comparable efficacy across modalities and suggest blunt-cannula delivery enhances patient comfort and recovery time.</p>\u0000 </section>\u0000 </div>","PeriodicalId":15546,"journal":{"name":"Journal of Cosmetic Dermatology","volume":"25 1","pages":""},"PeriodicalIF":2.5,"publicationDate":"2026-01-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12793817/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145952098","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neural Distribution–Guided Botulinum Toxin Injection for Platysma muscle: A Split-Neck Comparison With Conventional Technique","authors":"Kyu-Ho Yi,&nbsp;Isaac Kai Jie Wong,&nbsp;Irwan Junawanto,&nbsp;Gi-Woong Hong,&nbsp;Han Earl Lee,&nbsp;Jovian Wan","doi":"10.1111/jocd.70645","DOIUrl":"10.1111/jocd.70645","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>The platysma muscle plays a pivotal role in the formation of vertical neck bands and contributes to lower facial descent, making it a prime target for botulinum toxin type A (BoNT-A) in aesthetic neck rejuvenation. Conventional protocols typically involve injecting across the entire muscle, necessitating a high number of injection points and larger total doses, which may increase the risk of bruising, patient discomfort, and potential immunogenicity. Recent anatomical studies using Sihler's staining have demonstrated that motor innervation is predominantly concentrated in the upper portion of the platysma.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Aims</h3>\u0000 \u0000 <p>To evaluate a neural distribution–based BoNT-A injection strategy targeting only the motor-rich upper platysma, compared with the conventional whole-muscle injection approach.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Fifteen patients with prominent platysmal bands received BoNT-A injections (JETEMA THE TOXIN, JETEMA Inc., Korea) in a split-side design: The right platysma was injected using a conventional 30-point technique, and the left platysma received 15 targeted injections in the upper portion based on mapped motor entry points. Efficacy was assessed by the degree of platysmal band relaxation at follow-up.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Both techniques achieved comparable improvement in platysmal band appearance, despite the targeted side requiring 50% fewer injection points.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Motor innervation–guided BoNT-A injections may achieve equivalent clinical outcomes while reducing injection burden, toxin dose, and complication risk.</p>\u0000 </section>\u0000 </div>","PeriodicalId":15546,"journal":{"name":"Journal of Cosmetic Dermatology","volume":"25 1","pages":""},"PeriodicalIF":2.5,"publicationDate":"2026-01-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12789713/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145944542","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The PharmaResearch Under Eyelid Fine Line Severity Scale: Development and Validation of a Standardized Clinical Assessment Tool for Infraorbital Fine Wrinkles","authors":"Sun Young Choi,&nbsp;Beom Joon Kim","doi":"10.1111/jocd.70583","DOIUrl":"10.1111/jocd.70583","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Fine lines under the lower eyelid are among the earliest and most prominent signs of facial aging. However, despite growing interest in noninvasive aesthetic procedures targeting this area, there is currently no validated clinical scale specifically designed to assess the severity of infraorbital fine lines. Furthermore, existing assessment tools—such as those for lateral canthal lines or infraorbital hollowing—fail to adequately capture the unique characteristics of horizontally oriented fine wrinkles in this region.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Aims</h3>\u0000 \u0000 <p>To develop and validate a novel photonumeric clinical grading tool, called the PharmaResearch Under Eyelid Fine Line Severity (PULS) scale, for the standardized assessment of infraorbital fine lines.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>A total of 53 healthy adults without facial dermatologic conditions were photographed under standardized conditions. From the resulting image set, 73 photographs (53 unique and 20 duplicate images) were selected. Five board-certified dermatologists used our newly developed 5-grade photonumeric scale to independently evaluate the severity of infraorbital fine lines. Inter- and intra-rater reliability was assessed using Fleiss' and Cohen's Kappa, respectively. Agreement rates were also calculated.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Inter-rater reliability analysis yielded a Fleiss' Kappa of 0.6114, indicating good inter-rater agreement. All raters showed perfect intra-rater reliability, with Cohen's Kappa values of 1.0000. The overall agreement rate across all evaluations exceeded 80%, supporting the reproducibility and consistency of the PULS scale.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>The PULS scale is a validated, reliable, and practical photonumeric grading tool that can address an unmet need in aesthetic dermatology by facilitating standardized evaluation of treatment outcomes for infraorbital fine lines in both clinical research and routine practice.</p>\u0000 </section>\u0000 </div>","PeriodicalId":15546,"journal":{"name":"Journal of Cosmetic Dermatology","volume":"25 1","pages":""},"PeriodicalIF":2.5,"publicationDate":"2026-01-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12783871/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145933411","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}