Journal of Cosmetic Dermatology最新文献

{"title":"Predictive Factors of Better Patient Satisfaction After Phenol-Croton Peel: A Retrospective Study of 102 Patients","authors":"Gustavo Carneiro Nogueira,&nbsp;Raquel Iracema de Freitas Macedo Oliveira,&nbsp;Mariana Rocha Andrade,&nbsp;Bárbara Arze Rocha,&nbsp;Naides Carneiro Nogueira,&nbsp;Márcio Roberto Silva,&nbsp;Ana Carolina Tardin Rodrigues de Medeiros,&nbsp;Marina Vieira Rodrigues de Queiroz,&nbsp;Felipe Xavier Clo,&nbsp;Ticiano Teixeira Cesar Clo,&nbsp;Carlos Gustavo Wambier,&nbsp;Gisele Viana de Oliveira","doi":"10.1111/jocd.70609","DOIUrl":"10.1111/jocd.70609","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Phenol-croton peels are the gold standard for treating sun-damaged skin and static wrinkles; their long-term outcomes and patient satisfaction rates have yet to be thoroughly investigated.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Aims</h3>\u0000 \u0000 <p>To evaluate patient satisfaction and both short- and long-term cutaneous side effects in individuals undergoing phenol-croton peels.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Materials and Methods</h3>\u0000 \u0000 <p>This retrospective cohort study analyzed 102 female patients who underwent phenol-croton peels and were followed up until 3 months after the procedure to assess short-term side effects and to identify any long-term side effects that persisted beyond this period. Univariate and multivariate analyses were performed to assess patient satisfaction and long-term cutaneous side effects.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Ninety-two percent of patients rated their satisfaction as 4 or 5. Persistent cutaneous side effects were observed in 12% of cases (hypopigmentation: 6, hyperpigmentation: 5, dryness: 1). Despite mild hypopigmentation, five patients expressed willingness to undergo the procedure again. In the univariate analyses, full-face treatment, increasing age, and the absence of cutaneous side effects were significantly associated with higher satisfaction scores (<i>p</i> &lt; 0.05). In the multivariate model, age and the absence of cutaneous side effects remained independently and significantly associated with the outcome. Full-face treatment, although not statistically significant in the final model, showed a trend toward association and contributed to the overall adjustment. Notably, cutaneous side effects decreased at follow-up performed at least 15 months after the procedure compared to follow-up conducted within 3 months post-procedure (<i>p</i> = 0.039).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Phenol-croton peels demonstrated high satisfaction rates despite occasional prolonged cutaneous side effects. However, these side effects significantly decreased at ≥ 15 months post-procedure compared to ≤ 3 months post-procedure. Careful patient selection and expertise in performing this procedure remain crucial for optimizing outcomes.</p>\u0000 </section>\u0000 </div>","PeriodicalId":15546,"journal":{"name":"Journal of Cosmetic Dermatology","volume":"25 2","pages":""},"PeriodicalIF":2.5,"publicationDate":"2026-01-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12833551/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146046735","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comprehensive Facial Skin Rejuvenation With Long-Term Regular Intense Pulsed Light Therapy: A Real-World Study","authors":"Birao Fan,&nbsp;Ruixing Yu","doi":"10.1111/jocd.70691","DOIUrl":"10.1111/jocd.70691","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Intense pulsed light (IPL) therapy is widely used for facial rejuvenation, targeting vascular, pigmentary, and textural changes. However, comprehensive, real-world evidence evaluating long-term, regular IPL treatment across multiple dimensions of skin improvement remains limited.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Objectives</h3>\u0000 \u0000 <p>This study aimed to assess the efficacy and safety of long-term, regular IPL therapy in improving facial erythema, pigmentation, and wrinkles, and to identify predictors of favorable response.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>This retrospective real-world study included 236 patients who underwent six or more IPL sessions between 2020 and 2025. Patients were categorized as acne, rosacea, or cosmetic subjects. VISIA imaging quantified erythema, pigmentation, and wrinkle indices, while the Global Aesthetic Improvement Scale (GAIS) was used to assess aesthetic outcomes. Logistic regression identified predictors of good response.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Significant improvements were observed in erythema, pigmentation, and wrinkle indices after treatment (all <i>p</i> &lt; 0.05). Regular treatment intervals and total number of sessions were independently associated with better outcomes (OR = 13.62 and 3.80, respectively, both <i>p</i> &lt; 0.05). Patients with Fitzpatrick Type IV skin showed lower response rates (OR = 0.12, <i>p</i> = 0.001). VISIA analyses demonstrated quantifiable reductions in erythema and pigmentation areas, while wrinkles showed notable textural improvement. No severe adverse events occurred.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Long-term, regular IPL therapy effectively improves facial erythema, pigmentation, and wrinkles, confirming its value as a comprehensive rejuvenation strategy. Regular treatment intervals optimize cumulative effects, while objective imaging enhances precision in outcome evaluation. These findings support IPL as a safe, evidence-based, and multidimensional approach to long-term facial rejuvenation.</p>\u0000 </section>\u0000 </div>","PeriodicalId":15546,"journal":{"name":"Journal of Cosmetic Dermatology","volume":"25 2","pages":""},"PeriodicalIF":2.5,"publicationDate":"2026-01-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12833585/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146046778","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Regeneration in Aesthetic Medicine: Mechanisms, Evidence, and Clinical Boundaries","authors":"Antony de Paula Barbosa","doi":"10.1111/jocd.70669","DOIUrl":"10.1111/jocd.70669","url":null,"abstract":"&lt;div&gt;\u0000 \u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Background&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;Regeneration has emerged as a key concept in aesthetic medicine as the field evolves from predominantly volumetric correction toward biologically oriented strategies aimed at improving tissue quality, function, and long-term structural integrity. However, the widespread use of the term “regenerative” has often been used without biological precision, leading to conceptual overlap with repair, remodeling, and biostimulation. A critical evaluation of the biological basis and clinical evidence supporting regenerative claims is needed.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Objective&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;To critically synthesize current biological, translational, and clinical evidence related to skin regeneration in aesthetic medicine, with emphasis on extracellular matrix remodeling, immune modulation, mechanotransduction, and dermal–hypodermal integration, and to contextualize the regenerative potential and limitations of commonly used biomaterials.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Methods&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;A narrative review was conducted based on experimental studies, translational research, narrative and systematic reviews, and clinical investigations cited in the reference set. Evidence was qualitatively analyzed focusing on mechanisms of action, tissue-level interactions, immune responses, extracellular matrix dynamics, involvement of subcutaneous adipose compartments, and durability of clinical outcomes.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Results&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;Cutaneous regeneration is a multilevel functional process driven by coordinated extracellular matrix reorganization, controlled inflammation, mechanotransduction, angiogenesis, and dermal–hypodermal crosstalk. Particulate collagen biostimulators (poly-&lt;span&gt;l&lt;/span&gt;-lactic acid, poly-&lt;span&gt;d&lt;/span&gt;,&lt;span&gt;l&lt;/span&gt;-lactic acid, calcium hydroxyapatite, and polycaprolactone) demonstrate the most consistent evidence for sustained functional remodeling, with poly-&lt;span&gt;l&lt;/span&gt;-lactic acid showing the strongest longitudinal and histological support. Hyaluronic acid–based fillers and skinboosters primarily act as microenvironmental modulators with limited regenerative depth. Polydioxanone threads induce localized mechanobiological remodeling that is highly technique dependent. Biological bioregenerators, including polynucleotides, polydeoxyribonucleotides, and extracellular vesicles, show strong mechanistic plausibility but limited and heterogeneous clinical evidence.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Conclusion&lt;/h3&gt;\u0000 \u0000 ","PeriodicalId":15546,"journal":{"name":"Journal of Cosmetic Dermatology","volume":"25 1","pages":""},"PeriodicalIF":2.5,"publicationDate":"2026-01-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12828453/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146029657","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Where Should We Inject Botulinum Toxin for the Bunny Lines?","authors":"Kyu-Ho Yi,&nbsp;Soo-Bin Kim","doi":"10.1111/jocd.70673","DOIUrl":"10.1111/jocd.70673","url":null,"abstract":"&lt;p&gt;In aesthetic clinical practice, the treatment of “bunny lines”—the fine diagonal or vertical wrinkles that appear on the nasal sidewall during facial expressions such as smiling or laughing—has conventionally involved direct botulinum toxin (BoNT) injection into the crease itself (Figure 1). This approach assumes the presence of a hyperactive muscle immediately beneath the visible wrinkle. However, emerging evidence from detailed cadaveric dissections and ultrasonographic (US) analyses challenges this long-standing assumption and may explain the inconsistent and sometimes suboptimal outcomes associated with the “in-the-line” injection approach [&lt;span&gt;1&lt;/span&gt;].&lt;/p&gt;&lt;p&gt;Recent anatomical and imaging data demonstrate that the region between the medial canthus and nasal dorsum—where bunny lines manifest—is not underlain by a discrete muscle but rather represents a non-muscular interval termed the bunny triangle. In their multimodal study involving 39 cadaveric dissections and dynamic US examinations of 13 volunteers, Ahn et al. [&lt;span&gt;1&lt;/span&gt;] delineated this muscle-free triangle bordered by the procerus (superior-medial margin), transverse nasalis (superior-lateral margin), levator labii superioris alaeque nasi (LLSAN, inferomedial margin), and medial fibers of the orbicularis oculi (OOc, lateral margin). During active nose scrunching, US confirmed that the visible wrinkles correspond to skin folding over this non-muscular region, while adjacent muscles contract peripherally. The nasalis thickened dynamically in most participants, confirming its primary mechanical role in bunny line formation. Thus, the wrinkle is not generated by a localized underlying muscle but by convergent traction from neighboring muscles. Injecting BoNT directly into the crease therefore targets connective tissue and relies on passive diffusion, resulting in unpredictable efficacy and a higher likelihood of over- or under-treatment depending on the diffusion pattern [&lt;span&gt;2, 3&lt;/span&gt;].&lt;/p&gt;&lt;p&gt;The clinical implication of these findings is that the traditional “in-the-line” injection paradigm may be anatomically unsound. Instead, practitioners should adopt a border-targeted chemodenervation strategy focusing on the muscles actually responsible for wrinkle formation. This concept aligns with modern principles of functional anatomy, emphasizing selective modulation of active muscle borders rather than superficial crease injection.&lt;/p&gt;&lt;p&gt;Before injection, dynamic facial assessment should be performed. The patient is asked to smile, scrunch the nose, or express disgust to identify which borders contract most prominently—procerus, nasalis, LLSAN, or medial OOc. This individualized mapping acknowledges inter-patient variability in perinasal muscle dominance (Figure 2).&lt;/p&gt;&lt;p&gt;(Figure 3) Transverse nasalis (primary driver): Small intramuscular injections (1–2 U of BoNT-A) along its superior border on the upper nasal sidewall effectively attenuate line formation [&lt;span&gt;4&lt;/span&gt;].&lt;/p&gt;","PeriodicalId":15546,"journal":{"name":"Journal of Cosmetic Dermatology","volume":"25 1","pages":""},"PeriodicalIF":2.5,"publicationDate":"2026-01-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12828243/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146029714","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Global Recommendations for Facial Rejuvenation Using a Hyaluronic Acid and Calcium Hydroxyapatite Hybrid Injectable","authors":"Maurizio Cavallini,&nbsp;Andre Braz,&nbsp;Daniela Greiner-Krüger,&nbsp;Sylwia Lipko-Godlewska,&nbsp;Tapan Patel,&nbsp;Marva Safa,&nbsp;Sophie Shotter,&nbsp;Fernando Urdiales Gálvez,&nbsp;Graeme Kerson","doi":"10.1111/jocd.70608","DOIUrl":"10.1111/jocd.70608","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>The hybrid injectable HA-CaHA contains a formulated matrix of crosslinked hyaluronic acid (HA) gel with embedded calcium hydroxyapatite (CaHA) microspheres to increase skin elasticity and hydration as well as promote neocollagenesis, respectively. Clinical practice recommendations for use of HA-CaHA are limited.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Aims</h3>\u0000 \u0000 <p>The objective of this article was to provide global recommendations on safe and effective practices for injecting HA-CaHA.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Patient/Methods</h3>\u0000 \u0000 <p>An expert panel consisting of eight international consultants was invited to discuss and provide best-practice recommendations on HA-CaHA patient selection, skin laxity assessment, injection techniques, touch-up/retreatment practices, combination treatment protocols, and safety considerations.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>The expert panel recommended using HA-CaHA for structural support and soft tissue repositioning in patients with skin laxity, sagginess, and mild to moderate loss of volume and contour. They also recommended defining injection entry points by referring to the line of ligaments and the zygomatic arch and keeping injections in the lateral and thus less mobile areas of the face. Experts advised using a cannula instead of a needle, retreating only if mild to moderate skin laxity recurs, and injecting in small volumes. Measures to minimize potential side effects, including injection site responses, were discussed.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Expert clinical recommendations affirm the safe and effective use of HA-CaHA to improve soft tissue quality over time.</p>\u0000 </section>\u0000 </div>","PeriodicalId":15546,"journal":{"name":"Journal of Cosmetic Dermatology","volume":"25 1","pages":""},"PeriodicalIF":2.5,"publicationDate":"2026-01-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12824049/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146018626","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Radiofrequency Microneedling With 1927 nm Thulium Laser Versus Radiofrequency Microneedling Monotherapy for Rejuvenation of Photoaged Skin","authors":"Lynhda Nguyen,&nbsp;Marco Blessmann,&nbsp;Stefan W. Schneider,&nbsp;Katharina Herberger","doi":"10.1111/jocd.70685","DOIUrl":"10.1111/jocd.70685","url":null,"abstract":"&lt;div&gt;\u0000 \u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Background&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;The combination of radiofrequency microneedling (RFMN) with fractional 1927 nm thulium (Tm) laser has gained popularity in clinical practice. However, comparative studies remain limited.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Objectives&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;To evaluate the efficacy and safety of combined RFMN/Tm laser treatment versus RFMN alone for rejuvenation of photoaged skin of the lower face and neck area.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Material and Methods&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;A prospective, evaluator-blinded, clinical study. Patients were assigned to a combined protocol consisting of 1–3 RFMN treatment sessions immediately followed by Tm laser, supplemented by three additional Tm laser sessions at 6–8-week intervals. Study endpoints were compared with data from our previously published RFMN monotherapy cohort. Outcomes were assessed using validated clinical grading scales, computer-assisted analysis of submental volume, and a standardized color space system to quantify skin tone evening. Pain was assessed using a numeric rating scale. Adverse events (AEs) were monitored throughout the study period.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Results&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;26 received the combined treatment, and 27 patients were treated with RFMN alone. Mean ages were 50.7 ± 7.4 and 55.6 ± 8.9 years, respectively. Both groups showed significant reductions in submental volume without significant differences between them. However, only the combination group demonstrated a distinct improvement in hyperpigmented lesions, as quantified by the color analysis. Blinded evaluations noted improvements in the melomental area, jawline, and neck in both groups, while greater improvements in skin tone evening and therefore overall appearance were seen only in the combination group. No serious AEs were reported.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Conclusion&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;Both treatment modalities effectively addressed lower facial and neck laxity. The addition of Tm laser to RFMN provided additional benefits in treating pigmentary irregularities and improving overall clinical outcome without notably compromising downtime. Larger studies are warranted to validate these findings and assess long-term outcomes.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Trial Registration&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;This study was preregistered in clinicaltrials.gov (NCT06029725) on 23 August 2023&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 &lt;/div","PeriodicalId":15546,"journal":{"name":"Journal of Cosmetic Dermatology","volume":"25 1","pages":""},"PeriodicalIF":2.5,"publicationDate":"2026-01-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12824051/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146018763","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical Evaluation of an Integrated Tri-Modal Transdermal Device for Enhanced Serum Absorption","authors":"Youjin Kim,&nbsp;Seongwon Hong,&nbsp;Kiyoung Chang,&nbsp;Seoyeon Han,&nbsp;Huijun Leung,&nbsp;Jee Sun Lee,&nbsp;Soha Jeon,&nbsp;Hae Jo","doi":"10.1111/jocd.70674","DOIUrl":"10.1111/jocd.70674","url":null,"abstract":"&lt;p&gt;Physical transdermal delivery systems such as electroporation, sonophoresis, and iontophoresis have been studied for their potential to enhance cutaneous absorption of active ingredients, improving penetration and bioavailability in cosmetic and therapeutic applications [&lt;span&gt;1&lt;/span&gt;]. Electroporation delivers short high-voltage pulses that transiently disrupt the stratum corneum, forming micropores that allow passage of otherwise impermeable molecules [&lt;span&gt;2, 3&lt;/span&gt;]. Sonophoresis employs ultrasound waves (~1 MHz) to disorder intercellular lipid bilayers, widening diffusion pathways [&lt;span&gt;4&lt;/span&gt;]. Iontophoresis applies a low-level electrical current to drive charged actives via electro-repulsion and promote nonionic transport through electroosmosis [&lt;span&gt;5&lt;/span&gt;].&lt;/p&gt;&lt;p&gt;Combining physical enhancers is suggested to lead to additive or potentially synergistic improvements in transdermal flux [&lt;span&gt;6&lt;/span&gt;]. Previous studies have shown that combining two modalities enhances penetration more than either alone—for example, sonophoresis can lower the electroporation threshold and increase skin permeability, allowing iontophoresis to subsequently provide a sustained electrical driving force that maintains or augments flux [&lt;span&gt;1, 3, 6&lt;/span&gt;]. Although such dual-modality combinations have been explored, no clinical study has evaluated the integrated use of all three modalities or quantified tri-modal delivery using depth-resolved confocal Raman spectroscopy, particularly in consumer-grade devices.&lt;/p&gt;&lt;p&gt;This study used depth-resolved confocal Raman spectroscopy to assess penetration depth and concentration of a tri-modal delivery system compared with manual application. In this open-label crossover study (IRB approval: Ellead No. 240912T005), 22 healthy Korean women aged 23–60 years (mean ± standard deviation: 47.6 ± 9.4) without history of skin diseases were enrolled. Following a 30-min acclimatization (20°C–22°C; 40%–60% humidity), each participant received a 90-s serum application on one forearm. On the contralateral forearm, the same serum was applied followed by a single device application (electroporation + sonophoresis + iontophoresis). Device parameters were 9.2 V and 1 kHz for electroporation, 5 V and 1 kHz for iontophoresis, and 1 MHz ultrasound for sonophoresis, selected based on preclinical optimization and established safety-validated ranges in cosmetic skin-delivery applications. The serum contained plant-based collagen, cranberry biopeptides, fermented oligopeptides, and white chia peptides in a liposomal carrier. Raman spectroscopy (gen2 Skin Composition Analyzer; River Diagnostics, Rotterdam, Netherlands) was performed at baseline and 30 min after application, with 2 μm steps to 30 μm. Penetration quantity was expressed as Raman intensity relative to keratin (A.U./cm&lt;sup&gt;2&lt;/sup&gt;), and depth (μm) defined as the deepest point exceeding baseline. Statistical analyses were performed in SPSS version 27 (IBM, Armonk, NY, US","PeriodicalId":15546,"journal":{"name":"Journal of Cosmetic Dermatology","volume":"25 1","pages":""},"PeriodicalIF":2.5,"publicationDate":"2026-01-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12821079/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146010674","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of Fatigue on the Skin: Pilot Study on “996” Work-Life Pattern in China and the Influence of Their Lifestyle on the Skin","authors":"Xiaoyu Ma,&nbsp;Li Ma,&nbsp;Yimei Tan,&nbsp;Wencai Jiang,&nbsp;Pujos Muriel,&nbsp;Florante Ricarte,&nbsp;Doucet Olivier","doi":"10.1111/jocd.70679","DOIUrl":"10.1111/jocd.70679","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Modern living encouraged longer working hours and an increased sense of fatigue. In China, a rising trend called “996”, meaning working from 9 a.m. to 9 p.m., 6 days per week in succession, has raised concerns about the impact of fatigue on health, specifically on skin aging.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>A one-week, single center, self-controlled clinical study was conducted to evaluate the impact of fatigue on skin phenotypes, through the enrollment of 31 Chinese women with a 996 work-life pattern based on Life Style questionnaires and Chalder fatigue scale. Clinical grading and instrumental measurements were conducted before the working week, after 1, 3, and 5 working days.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>The fatigue score of the participants accumulated during the working week. From clinical grading, periocular fine lines, fine lines of the cheeks, and forehead wrinkles were significantly worsened in the working week compared to the weekend. Skin elasticity parameters R0, R5, and R7 were also significantly worse compared to the weekend. Significantly increased porphyrin, yellowness, and decrease of redness of skin during working times were also observed. Additionally, the clinical evaluations were well recorded with self-perceptions from the questionnaire.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Fatigue is an inescapable stressor in modern life that impacts skin's health and appearance by accelerating signs of aging, altering skin color, and increasing risk of acne. This is a pilot study analyzing the population with intensive work-life patterns, serving as a reference to comprehensively assess the impact of modern living on skin.</p>\u0000 </section>\u0000 </div>","PeriodicalId":15546,"journal":{"name":"Journal of Cosmetic Dermatology","volume":"25 1","pages":""},"PeriodicalIF":2.5,"publicationDate":"2026-01-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12824052/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146018674","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Topical Volumizing Cream Improves Facial Volume and Skin Health in Adults With Rapid Weight Loss From Pharmacologic (GLP-1/GIP Agonists), Surgical, or Behavioral Interventions","authors":"Nhi Nguyen,&nbsp;Alejandra Aguilar,&nbsp;Nasima Afzal,&nbsp;Andy Lee,&nbsp;Wardah Akram,&nbsp;Minh N. Duong,&nbsp;Raja K. Sivamani","doi":"10.1111/jocd.70681","DOIUrl":"10.1111/jocd.70681","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>GLP-1 receptor agonists (GLP-1) and dual GLP-1/gastric inhibitory polypeptide (GIP) agonists emerged in recent years to promote weight loss. By reducing subcutaneous fat, collagen, and overall structural support of the skin, rapid weight loss can lead to visual face aging.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Aims</h3>\u0000 \u0000 <p>This study investigates the synergistic effect of a multi-ingredient topical that acts on different skin levels to treat facial aging in individuals experiencing rapid weight loss from GLP-1 and GIP/GLP-1 agonist use.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Patients/Methods</h3>\u0000 \u0000 <p>In this 12-week study, 33 participants from the Sacramento region were given the same topical volumizing cream (Vol.U.Lift, Image Skincare). Participants had 6 visits: screening, baseline, weeks 2, 4, 8, and 12. Tolerability assessments, facial photography, and measurements of hydration, elasticity, and wrinkles were acquired.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>29 subjects completed all study related procedures. Wrinkle severity appearance decreased at week 4 (14.5%, <i>p</i> &lt; 0.001) and 12 (20.7%, <i>p</i> &lt; 0.001). The ultrasound based skin and subcutaneous thickness increased at week 4 (17.3%, <i>p</i> = 0.04) and 12 (20.1%, <i>p</i> = 0.015); TEWL decreased at week 4 (10.39%, <i>p</i> ≤ 0.02) and 12 (12.7%, <i>p</i> ≤ 0.02); Skin hydration increased at week 2 (21.29%, <i>p</i> ≤ 0.01), 4 (19.50%, <i>p</i> ≤ 0.02), and week 12 (21.8%, <i>p</i> ≤ 0.02); Firmness (22.5%, <i>p</i> ≤ 0.002), viscoelasticity (13.1%, <i>p</i> ≤ 0.02) and net elasticity (23.2%, <i>p</i> ≤ 0.0002) increased at week 12.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>The use of a topical volumizing cream improved the appearance of facial volume, wrinkles, and biophysical characteristics in participants who had undergone rapid weight loss primarily due to GLP-1/GIP agonist use.</p>\u0000 </section>\u0000 </div>","PeriodicalId":15546,"journal":{"name":"Journal of Cosmetic Dermatology","volume":"25 1","pages":""},"PeriodicalIF":2.5,"publicationDate":"2026-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12817327/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146010662","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Novel Application of Injectable PRF for Superior Sulcus Hollowing","authors":"Nese Arslan,&nbsp;Alperen Bahar,&nbsp;Ahmet Alp Bilgic,&nbsp;Şule Barman Kakil","doi":"10.1111/jocd.70666","DOIUrl":"10.1111/jocd.70666","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Superior sulcus hollowing is a frequent esthetic concern, commonly managed with synthetic fillers or fat grafts; however, these approaches carry potential risks and costs. Injectable platelet-rich fibrin (i-PRF), an autologous regenerative biomaterial, has shown promise in dermatologic and dental applications, but its use for periocular volume restoration remains unexplored.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Aims</h3>\u0000 \u0000 <p>To evaluate the efficacy, safety, and patient satisfaction of i-PRF injections for the correction of superior sulcus hollowing.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Patients/Methods</h3>\u0000 \u0000 <p>This single-center retrospective study included 24 eyes of 12 patients treated with i-PRF between 2021 and 2024. Sulcus depth was measured at baseline and at 3 and 6 months posttreatment. Subjective satisfaction was assessed using a binary scale. i-PRF was prepared using a low-speed centrifugation protocol and injected suborbicularis in three sessions spaced 1 week apart.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>A significant reduction in superior sulcus depth was observed from baseline to 3 months (13.3 ± 2.8 mm to 9.2 ± 3.7 mm; <i>p</i> = 0.002), followed by mild regression at 6 months (10.5 ± 3.3 mm). Patient satisfaction was high, with 18 out of 24 eyes (75%) reporting favorable outcomes at 3 months. No adverse effects were recorded.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>This first clinical report of i-PRF for upper eyelid hollowing suggests that it may serve as a safe, autologous, and minimally invasive alternative for superior sulcus volume restoration. Further prospective studies with standardized outcome measures are warranted to validate these findings.</p>\u0000 </section>\u0000 </div>","PeriodicalId":15546,"journal":{"name":"Journal of Cosmetic Dermatology","volume":"25 1","pages":""},"PeriodicalIF":2.5,"publicationDate":"2026-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12820442/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146010652","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}