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Impact of Fatigue on the Skin: Pilot Study on “996” Work-Life Pattern in China and the Influence of Their Lifestyle on the Skin 疲劳对皮肤的影响:中国“996”工作生活模式及其生活方式对皮肤影响的初步研究
IF 2.5 4区 医学 Q2 DERMATOLOGY Pub Date : 2026-01-21 DOI: 10.1111/jocd.70679
Xiaoyu Ma, Li Ma, Yimei Tan, Wencai Jiang, Pujos Muriel, Florante Ricarte, Doucet Olivier

Background

Modern living encouraged longer working hours and an increased sense of fatigue. In China, a rising trend called “996”, meaning working from 9 a.m. to 9 p.m., 6 days per week in succession, has raised concerns about the impact of fatigue on health, specifically on skin aging.

Methods

A one-week, single center, self-controlled clinical study was conducted to evaluate the impact of fatigue on skin phenotypes, through the enrollment of 31 Chinese women with a 996 work-life pattern based on Life Style questionnaires and Chalder fatigue scale. Clinical grading and instrumental measurements were conducted before the working week, after 1, 3, and 5 working days.

Results

The fatigue score of the participants accumulated during the working week. From clinical grading, periocular fine lines, fine lines of the cheeks, and forehead wrinkles were significantly worsened in the working week compared to the weekend. Skin elasticity parameters R0, R5, and R7 were also significantly worse compared to the weekend. Significantly increased porphyrin, yellowness, and decrease of redness of skin during working times were also observed. Additionally, the clinical evaluations were well recorded with self-perceptions from the questionnaire.

Conclusion

Fatigue is an inescapable stressor in modern life that impacts skin's health and appearance by accelerating signs of aging, altering skin color, and increasing risk of acne. This is a pilot study analyzing the population with intensive work-life patterns, serving as a reference to comprehensively assess the impact of modern living on skin.

背景:现代生活促使人们工作时间更长,疲劳感更强。在中国,一种名为“996”的新兴趋势,即从早上9点开始工作。到晚上9点。人们开始关注疲劳对健康的影响,特别是对皮肤衰老的影响。方法:采用基于生活方式问卷和Chalder疲劳量表的996种工作-生活模式,对31名中国女性进行为期一周的单中心自我对照临床研究,以评估疲劳对皮肤表型的影响。临床分级和仪器测量分别在工作周前、1、3和5个工作日后进行。结果:被试的疲劳评分在工作周内累积。从临床分级来看,与周末相比,工作日的眼周细纹、脸颊细纹和前额皱纹明显恶化。与周末相比,皮肤弹性参数R0、R5和R7也明显变差。在工作期间,还观察到卟啉明显增加,皮肤发黄,皮肤发红减少。此外,临床评估与问卷中的自我认知被很好地记录下来。结论:疲劳是现代生活中不可避免的压力源,它通过加速衰老、改变肤色和增加痤疮的风险来影响皮肤的健康和外观。这是一项针对工作生活密集人群的初步研究,为全面评估现代生活对皮肤的影响提供参考。
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引用次数: 0
Topical Volumizing Cream Improves Facial Volume and Skin Health in Adults With Rapid Weight Loss From Pharmacologic (GLP-1/GIP Agonists), Surgical, or Behavioral Interventions 局部增容乳膏可改善因药物(GLP-1/GIP激动剂)、手术或行为干预而体重迅速减轻的成人面部体积和皮肤健康。
IF 2.5 4区 医学 Q2 DERMATOLOGY Pub Date : 2026-01-20 DOI: 10.1111/jocd.70681
Nhi Nguyen, Alejandra Aguilar, Nasima Afzal, Andy Lee, Wardah Akram, Minh N. Duong, Raja K. Sivamani

Background

GLP-1 receptor agonists (GLP-1) and dual GLP-1/gastric inhibitory polypeptide (GIP) agonists emerged in recent years to promote weight loss. By reducing subcutaneous fat, collagen, and overall structural support of the skin, rapid weight loss can lead to visual face aging.

Aims

This study investigates the synergistic effect of a multi-ingredient topical that acts on different skin levels to treat facial aging in individuals experiencing rapid weight loss from GLP-1 and GIP/GLP-1 agonist use.

Patients/Methods

In this 12-week study, 33 participants from the Sacramento region were given the same topical volumizing cream (Vol.U.Lift, Image Skincare). Participants had 6 visits: screening, baseline, weeks 2, 4, 8, and 12. Tolerability assessments, facial photography, and measurements of hydration, elasticity, and wrinkles were acquired.

Results

29 subjects completed all study related procedures. Wrinkle severity appearance decreased at week 4 (14.5%, p < 0.001) and 12 (20.7%, p < 0.001). The ultrasound based skin and subcutaneous thickness increased at week 4 (17.3%, p = 0.04) and 12 (20.1%, p = 0.015); TEWL decreased at week 4 (10.39%, p ≤ 0.02) and 12 (12.7%, p ≤ 0.02); Skin hydration increased at week 2 (21.29%, p ≤ 0.01), 4 (19.50%, p ≤ 0.02), and week 12 (21.8%, p ≤ 0.02); Firmness (22.5%, p ≤ 0.002), viscoelasticity (13.1%, p ≤ 0.02) and net elasticity (23.2%, p ≤ 0.0002) increased at week 12.

Conclusions

The use of a topical volumizing cream improved the appearance of facial volume, wrinkles, and biophysical characteristics in participants who had undergone rapid weight loss primarily due to GLP-1/GIP agonist use.

背景:近年来出现了GLP-1受体激动剂(GLP-1)和GLP-1/胃抑制多肽(GIP)双激动剂来促进减肥。通过减少皮下脂肪、胶原蛋白和皮肤的整体结构支持,快速减肥会导致视觉面部老化。目的:本研究探讨了一种多成分局部作用于不同皮肤水平的治疗面部衰老的协同效应,这些患者因使用GLP-1和GIP/GLP-1激动剂而体重迅速减轻。患者/方法:在这项为期12周的研究中,来自萨克拉门托地区的33名参与者被给予相同的局部丰胸霜(Vol.U. 2)。Lift, Image护肤)。参与者有6次就诊:筛查、基线、第2周、第4周、第8周和第12周。获得耐受性评估、面部摄影、水合作用、弹性和皱纹测量。结果:29名受试者完成了所有研究相关程序。皱纹严重程度在第4周减少(14.5%,p)。结论:局部增容霜的使用改善了主要由于使用GLP-1/GIP激动剂而经历快速减肥的参与者的面部体积、皱纹和生物物理特征。
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引用次数: 0
A Novel Application of Injectable PRF for Superior Sulcus Hollowing 可注射PRF在上沟成形术中的新应用。
IF 2.5 4区 医学 Q2 DERMATOLOGY Pub Date : 2026-01-20 DOI: 10.1111/jocd.70666
Nese Arslan, Alperen Bahar, Ahmet Alp Bilgic, Şule Barman Kakil

Background

Superior sulcus hollowing is a frequent esthetic concern, commonly managed with synthetic fillers or fat grafts; however, these approaches carry potential risks and costs. Injectable platelet-rich fibrin (i-PRF), an autologous regenerative biomaterial, has shown promise in dermatologic and dental applications, but its use for periocular volume restoration remains unexplored.

Aims

To evaluate the efficacy, safety, and patient satisfaction of i-PRF injections for the correction of superior sulcus hollowing.

Patients/Methods

This single-center retrospective study included 24 eyes of 12 patients treated with i-PRF between 2021 and 2024. Sulcus depth was measured at baseline and at 3 and 6 months posttreatment. Subjective satisfaction was assessed using a binary scale. i-PRF was prepared using a low-speed centrifugation protocol and injected suborbicularis in three sessions spaced 1 week apart.

Results

A significant reduction in superior sulcus depth was observed from baseline to 3 months (13.3 ± 2.8 mm to 9.2 ± 3.7 mm; p = 0.002), followed by mild regression at 6 months (10.5 ± 3.3 mm). Patient satisfaction was high, with 18 out of 24 eyes (75%) reporting favorable outcomes at 3 months. No adverse effects were recorded.

Conclusions

This first clinical report of i-PRF for upper eyelid hollowing suggests that it may serve as a safe, autologous, and minimally invasive alternative for superior sulcus volume restoration. Further prospective studies with standardized outcome measures are warranted to validate these findings.

背景:上沟空心化是一个常见的美学问题,通常通过人工填充物或脂肪移植来处理;然而,这些方法有潜在的风险和成本。可注射的富血小板纤维蛋白(i-PRF)是一种自体再生生物材料,在皮肤科和牙科方面的应用前景广阔,但其在眼周体积修复方面的应用仍未探索。目的:评价注射i-PRF矫正上沟凹陷的疗效、安全性及患者满意度。患者/方法:这项单中心回顾性研究包括在2021年至2024年间接受i-PRF治疗的12例患者的24只眼睛。在基线和治疗后3个月和6个月测量沟深度。主观满意度采用二值量表进行评估。采用低速离心工艺制备i-PRF,每隔1周注射3次轮匝肌下。结果:从基线到3个月(13.3±2.8 mm至9.2±3.7 mm; p = 0.002),观察到上沟深度显着减少,随后在6个月(10.5±3.3 mm)轻度消退。患者满意度很高,24只眼睛中有18只(75%)在3个月时报告了良好的结果。无不良反应记录。结论:这是i-PRF治疗上睑凹陷的第一份临床报告,表明它可以作为一种安全、自体、微创的上睑沟体积修复方法。需要进一步采用标准化结果测量的前瞻性研究来验证这些发现。
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引用次数: 0
Managing Aesthetic Needs in Prescription Medication-Driven Rapid Weight Loss Patients: Results of an International Consensus. The Clinician Perspective 管理处方药物驱动的快速减肥患者的审美需求:国际共识的结果。临床医生的观点。
IF 2.5 4区 医学 Q2 DERMATOLOGY Pub Date : 2026-01-20 DOI: 10.1111/jocd.70644
Andreas Nikolis, Michael T. Somenek, Steven Dayan, Hugues Cartier, Sabrina G. Fabi, Luiz Avelar, Johnny Franco, Konstantin Frank, Alessandra Haddad, Mohammed A. Alsufyani, Jeff Huang, Inna Prygova, Tyler Safran

Introduction

The global prevalence of obesity has continued to increase at alarming rates. More recently, there has been an exponential increase in the usage of GLP1 agonists in both clinically obese patients and those seeking weight loss. As a result, there has been an influx of patients who are noticing substantial weight loss and changes to their bodies. Given this surge, it is of utmost importance to have homogeneity in clinical guidelines. A consensus panel was created to discuss clinical scenarios, definitions, and set the stage for the appropriate treatment of patients who have undergone massive weight loss.

Methods

To set standards for nonsurgical rejuvenation of patients at different ages, weight loss patterns, and genders, a consensus panel of 10 panelists was created with advanced expertise and knowledge on this patient population. Each panelist filled out a survey that addressed panelist demographics, including practice patterns and patient demographics, as well as treatment guidelines in both male and female patients. Following the survey, the panelists met to discuss preliminary results and obtain qualitative data to support their conclusions on the criteria.

Results

All 10 respondents (100%) were able to complete the survey in its entirety. The panel demonstrates the need to assess and address each treatment region individually in these patients. It also emphasizes the need to consider the appropriate range of volumization based on factors such as age, gender, and the degree of weight loss. While the consensus suggests initiating biostimulator treatment concurrently with weight loss to mitigate fat pad deflation and skin laxity, uncertainties remain regarding the optimal timing and dosing.

Conclusion

In conclusion, this consensus panel represents the first international effort to provide clinical guidance specifically for patients experiencing medication-derived weight loss (MDWL). When creating a treatment plan for the MDWL patient, following them throughout the weight loss journey is essential to understand the more global volume changes that they may be observing.

导言:全球肥胖患病率继续以惊人的速度增长。最近,GLP1激动剂在临床肥胖患者和寻求减肥的患者中的使用呈指数增长。结果,大量患者注意到他们的体重明显减轻,身体也发生了变化。鉴于这种激增,在临床指南中保持一致性是至关重要的。成立了一个共识小组,讨论临床情景、定义,并为大规模减肥患者的适当治疗奠定基础。方法:为制定不同年龄、减肥模式和性别患者的非手术年轻化标准,我们建立了一个由10名专家组成的共识小组,他们对这一患者群体具有先进的专业知识和知识。每位小组成员都填写了一份调查问卷,内容涉及小组成员的人口统计数据,包括实践模式和患者人口统计数据,以及男性和女性患者的治疗指南。调查结束后,小组成员开会讨论初步结果,并获得定性数据,以支持他们关于标准的结论。结果:10名被调查者(100%)均能完整完成调查。该小组表明,有必要对这些患者的每个治疗区域进行单独评估和处理。它还强调需要根据年龄、性别和体重减轻程度等因素考虑适当的体积范围。虽然普遍建议在减肥的同时开始生物刺激治疗,以减轻脂肪垫收缩和皮肤松弛,但关于最佳时间和剂量的不确定性仍然存在。结论:总而言之,这个共识小组代表了第一个国际努力,专门为经历药物源性减肥(MDWL)的患者提供临床指导。在为MDWL患者制定治疗计划时,在整个减肥过程中跟踪他们,对于了解他们可能观察到的更全面的体积变化至关重要。
{"title":"Managing Aesthetic Needs in Prescription Medication-Driven Rapid Weight Loss Patients: Results of an International Consensus. The Clinician Perspective","authors":"Andreas Nikolis,&nbsp;Michael T. Somenek,&nbsp;Steven Dayan,&nbsp;Hugues Cartier,&nbsp;Sabrina G. Fabi,&nbsp;Luiz Avelar,&nbsp;Johnny Franco,&nbsp;Konstantin Frank,&nbsp;Alessandra Haddad,&nbsp;Mohammed A. Alsufyani,&nbsp;Jeff Huang,&nbsp;Inna Prygova,&nbsp;Tyler Safran","doi":"10.1111/jocd.70644","DOIUrl":"10.1111/jocd.70644","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Introduction</h3>\u0000 \u0000 <p>The global prevalence of obesity has continued to increase at alarming rates. More recently, there has been an exponential increase in the usage of GLP1 agonists in both clinically obese patients and those seeking weight loss. As a result, there has been an influx of patients who are noticing substantial weight loss and changes to their bodies. Given this surge, it is of utmost importance to have homogeneity in clinical guidelines. A consensus panel was created to discuss clinical scenarios, definitions, and set the stage for the appropriate treatment of patients who have undergone massive weight loss.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>To set standards for nonsurgical rejuvenation of patients at different ages, weight loss patterns, and genders, a consensus panel of 10 panelists was created with advanced expertise and knowledge on this patient population. Each panelist filled out a survey that addressed panelist demographics, including practice patterns and patient demographics, as well as treatment guidelines in both male and female patients. Following the survey, the panelists met to discuss preliminary results and obtain qualitative data to support their conclusions on the criteria.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>All 10 respondents (100%) were able to complete the survey in its entirety. The panel demonstrates the need to assess and address each treatment region individually in these patients. It also emphasizes the need to consider the appropriate range of volumization based on factors such as age, gender, and the degree of weight loss. While the consensus suggests initiating biostimulator treatment concurrently with weight loss to mitigate fat pad deflation and skin laxity, uncertainties remain regarding the optimal timing and dosing.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>In conclusion, this consensus panel represents the first international effort to provide clinical guidance specifically for patients experiencing medication-derived weight loss (MDWL). When creating a treatment plan for the MDWL patient, following them throughout the weight loss journey is essential to understand the more global volume changes that they may be observing.</p>\u0000 </section>\u0000 </div>","PeriodicalId":15546,"journal":{"name":"Journal of Cosmetic Dermatology","volume":"25 1","pages":""},"PeriodicalIF":2.5,"publicationDate":"2026-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12820441/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146010660","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Advances in the Treatment of Striae Distensae 腹胀纹的治疗进展。
IF 2.5 4区 医学 Q2 DERMATOLOGY Pub Date : 2026-01-20 DOI: 10.1111/jocd.70683
Yi Wu, Huaigu Wang

Background

Striae distensae (SD) is a common cutaneous condition with an estimated incidence of 56%, associated with rapid skin expansion, hormonal changes, and genetic factors. While traditional treatments (e.g., topical tretinoin, various lasers) exhibit limitations, non-ablative fractional laser (NAFL), injectable fillers, alpha hydroxy acids (AHAs), and combination therapies have emerged as promising modalities, though certain aspects require clarification.

Aims

This review aims to synthesize current evidence on the pathogenesis and management of SD, with a particular focus on evaluating the recent progress of 1565 nm NAFL to provide guidance for clinical practice and future research.

Methods

A systematic literature search was conducted across PubMed, Web of Science, and Scopus databases following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. The review prioritized randomized controlled trials, meta-analyses, and substantial clinical studies published between 2010 and 2025.

Results

Striae distensae (SD) arises from mechanical tension, hormonal imbalance, and inflammation-induced dermal matrix disruption. Efficacious treatments include alpha hydroxy acids, injectable fillers, 1540 nm Er:Glass laser, 532 nm Nd:YAG laser, picosecond lasers, intense pulsed light, and combination therapies (e.g., fractional microneedling/CO2 laser + PRP). 1565 nm NAFL exhibits favorable efficacy, safety, and tolerance, with enhanced outcomes in combinations.

Conclusions

The management of SD is evolving towards individualized combination strategies. Fractional microneedling plus PRP and fractional CO2 laser resurfacing with PRP achieve good results in SD rubra and alba, while 1565 nm NAFL represents a significant advance in minimally invasive treatment. Future research should prioritize large-scale studies, standardized assessment methods, and exploration of novel combinations.

背景:扩张纹(SD)是一种常见的皮肤疾病,估计发病率为56%,与皮肤快速扩张、激素变化和遗传因素有关。虽然传统的治疗方法(如局部维甲酸、各种激光)存在局限性,但非烧蚀分数激光(NAFL)、可注射填充剂、α羟基酸(AHAs)和联合治疗已经成为有希望的治疗方式,尽管某些方面需要澄清。目的:本文旨在综合目前关于SD发病机制和治疗的证据,重点评价1565 nm NAFL的最新进展,为临床实践和未来的研究提供指导。方法:根据系统评价和meta分析的首选报告项目(PRISMA)指南,对PubMed、Web of Science和Scopus数据库进行系统文献检索。该综述优先考虑了2010年至2025年间发表的随机对照试验、荟萃分析和大量临床研究。结果:扩张纹是由机械张力、激素失衡和炎症引起的真皮基质破坏引起的。有效的治疗方法包括α羟基酸、可注射填料、1540 nm Er:Glass激光、532 nm Nd:YAG激光、皮秒激光、强脉冲光和联合治疗(例如,分数微针/CO2激光+ PRP)。1565 nm NAFL具有良好的疗效、安全性和耐受性,联合用药可提高疗效。结论:SD的治疗正朝着个体化联合治疗的方向发展。分式微针加PRP和分式CO2激光表面置换加PRP在SD红白斑中取得了良好的效果,而1565 nm NAFL在微创治疗方面取得了重大进展。未来的研究应优先考虑大规模研究、标准化评估方法和探索新的组合。
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引用次数: 0
Complications of Dermal Injectables—A Retrospective Study 皮肤注射并发症的回顾性研究。
IF 2.5 4区 医学 Q2 DERMATOLOGY Pub Date : 2026-01-19 DOI: 10.1111/jocd.70582
Lynhda Nguyen, Stefan W. Schneider, Ute Siemann-Harms, Katharina Herberger

Background

Hyaluronic acid (HA)-based injectables are generally considered safe. However, short- and long-term complications may occur.

Objective

To evaluate complications related to soft-tissue augmentation presented to the Department of Dermatology at a university hospital.

Materials and Methods

A retrospective analysis was conducted using electronic medical records from January 2019 to January 2025. Adverse events related to HA-based injectables, their management, and outcomes were identified and evaluated.

Results

Thirty-one patients (mean age: 50.4 years) were included in the analysis. Injections have been administered by cosmeticians (2/31), nonmedical practitioners (2/31), or individuals of unknown qualification. The most common complications were biofilm formation and chronic immune reactions, followed by abscesses, Tyndall effect, vascular occlusion, and filler migration. Over half of the products involved were either uncertified or of unknown origin.

Conclusion

The findings highlight the need for qualified practitioners, careful product selection, and adherence to standardized techniques. Enhancing practitioner education, establishing evidence-based protocols, and strengthening regulatory oversight are essential to ensure patient safety in aesthetic medicine.

背景:透明质酸(HA)注射剂通常被认为是安全的。然而,短期和长期的并发症可能发生。目的:评价某大学附属医院皮肤科软组织隆胸术的并发症。材料与方法:对2019年1月至2025年1月的电子病历进行回顾性分析。确定并评估与ha注射剂相关的不良事件及其管理和结果。结果:31例患者被纳入分析,平均年龄50.4岁。注射由美容师(2/31)、非医疗从业人员(2/31)或资格不明的个人进行。最常见的并发症是生物膜形成和慢性免疫反应,其次是脓肿、廷德尔效应、血管闭塞和填充物迁移。超过一半的涉事产品要么未经认证,要么来源不明。结论:研究结果强调需要合格的从业人员,仔细的产品选择,并坚持标准化的技术。加强从业者教育,建立循证协议,加强监管监督是确保患者安全的必要条件。
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引用次数: 0
When Microneedling Backfires: A Hidden Risk of Hair Shaft Fragility in AGA Patients 当微针适得其反:AGA患者毛干脆弱的隐藏风险。
IF 2.5 4区 医学 Q2 DERMATOLOGY Pub Date : 2026-01-19 DOI: 10.1111/jocd.70682
Wen Xu, Jinlong luo, Yeqin Dai
<p>Microneedling is increasingly used as an adjunctive treatment for androgenetic alopecia (AGA), aiming to enhance transdermal delivery of minoxidil and activate perifollicular signaling through controlled dermal injury [<span>1, 2</span>]. While short-term efficacy has been reported, the safety margins of low-depth yet high-frequency protocols remain incompletely defined. Notably, hair-shaft structural damage has not been systematically described as a complication of microneedling for AGA. Here, we report two patients who developed paradoxical cosmetic deterioration characterized by hair-shaft fragility and breakage following repeated low-depth microneedling, despite an initial favorable response.</p><p>Patient 1 was a 37-year-old man with a 3-year history of AGA who underwent weekly microneedling using a 500-μm roller, combined with twice-daily topical 5% minoxidil and oral finasteride (1 mg daily) for 12 months. No topical anesthesia or occlusive dressing was used. Clinical improvement during the first 9 months was reported by the patient and supported by serial clinical photography and trichoscopy, whereas diffuse thinning developed over the final 3 months. Trichoscopy at the time of deterioration revealed anisotrichosis and numerous short, broken hairs consistent with shaft fragility (Figure 1a,b). Concurrent scanning electron microscopy (SEM) demonstrated focal cuticle–cortex delamination, widened inter-scale spaces, and deformation of cuticular plates, consistent with mechanical hair-shaft trauma (Figure 1c). The patient denied medication changes, systemic illness, or altered grooming practices. Scalp examination showed no erythema, folliculitis, or scale.</p><p>Patient 2 was a 45-year-old woman with a 10-year history of progressive vertex thinning who received the same weekly microneedling protocol with topical 5% minoxidil. Hair appearance improved during the first 3 months, based on patient report and clinical inspection, but deteriorated by month five, with prominent short, broken hairs and a scissor-cut pattern at the vertex (Figure 2a,b). SEM revealed lifted, fragmented, and detached cuticular scales, consistent with mechanical shaft injury (Figure 2c). She reported no recent physical trauma, new hair products, or changes in hair-care routines. Scalp examination was otherwise unremarkable.</p><p>Both cases followed a biphasic course: initial cosmetic improvement followed by reduced apparent hair bulk attributable to fracture-shortened fibers rather than increased shedding. This pattern argues against telogen effluvium, which typically presents with intact fibers and diffuse shedding [<span>3</span>]. The convergence of trichoscopic findings (broken hairs) and SEM-confirmed cuticular disruption supports iatrogenic hair-shaft damage as the proximate process [<span>4</span>]. Trichotillomania, alopecia areata, traction alopecia, and chemical injury were unlikely based on clinical history and trichoscopy. The absence of erythema, pustul
支持本研究结果的数据可根据通讯作者的合理要求提供。
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引用次数: 0
Efficacy and Safety of Punch Excision Combined With Adjuvant Therapies for Hypertrophic Scars and Keloids: A Narrative Review 穿孔切除联合辅助治疗肥厚性疤痕和瘢痕疙瘩的疗效和安全性:一篇叙述性综述。
IF 2.5 4区 医学 Q2 DERMATOLOGY Pub Date : 2026-01-19 DOI: 10.1111/jocd.70622
Qiang Fang, Xin Lin, Wen Liang, Weiming Qiu

Background

Pathological scars manifest as firm, elevated, erythematous plaques, or nodules after skin injury. As challenging wound-healing complications, hypertrophic scars and keloids significantly compromise aesthetics while causing functional impairment and psychosocial distress. Consequently, their management remains a central focus in dermatology. The skin punch has undergone substantial technical advancements, emerging as a promising therapeutic modality.

Methods

To evaluate the efficacy of punch-based techniques in managing pathological scars, we conducted a comprehensive literature search using Boolean logic across electronic databases, with the core search strategy built upon the following terms: (“skin punch” OR “punch excision” OR “punch volume reduction”) AND (“pathological scar” OR “hypertrophic scar” OR “keloid”). Additional relevant studies were identified through citation tracking of the retrieved articles. This review systematically examines recent advancements in punch-assisted scar management, with particular focus on the mechanistic basis, diverse therapeutic modalities, clinical efficacy, and associated complications.

Results

This systematic appraisal of punch volume reduction for pathological scars affirms its robust efficacy in restoring aesthetic contour and functional integrity, while concurrently revealing substantial interpatient heterogeneity in therapeutic response and protracted convalescence intervals. Although the technique's clinical value is well-established, a critical deficit persists in stratified evidence across scar phenotypic spectra and temporal disease dynamics, with no codified protocols to direct therapeutic application. Confronted by the profound quality-of-life impairment attributable to pathological scars and accelerating clinical necessities, forthcoming research mandates large-scale prospective cohorts with prolonged surveillance, emphasizing technical innovation, preemptive complication management, and individualized treatment algorithms. The consolidated insights presented herein deliver both actionable guidance for contemporary evidence-based practice and a foundational conceptual architecture for future technological evolution in scar therapeutics.

背景:病理性疤痕表现为皮肤损伤后硬化、升高、红斑斑块或结节。作为具有挑战性的伤口愈合并发症,增生性疤痕和瘢痕疙瘩显著损害美学,同时引起功能障碍和心理社会困扰。因此,他们的管理仍然是皮肤病学的中心焦点。皮肤穿孔已经经历了实质性的技术进步,成为一种有前途的治疗方式。方法:为了评估基于打孔技术治疗病理性疤痕的效果,我们在电子数据库中使用布尔逻辑进行了全面的文献检索,核心搜索策略建立在以下术语上:(“皮肤打孔”或“打孔切除”或“打孔体积缩小”)和(“病理性疤痕”或“增生性疤痕”或“瘢痕疙瘩”)。通过对检索文章的引文跟踪,确定了其他相关研究。这篇综述系统地研究了最近在打孔辅助疤痕治疗方面的进展,特别关注了打孔辅助疤痕治疗的机制基础、不同的治疗方式、临床疗效和相关并发症。结果:对病理性疤痕的冲孔体积减少的系统评估证实了其在恢复美学轮廓和功能完整性方面的强大功效,同时也揭示了患者在治疗反应和延长的康复时间方面的巨大异质性。尽管该技术的临床价值已经确立,但在疤痕表型谱和时间疾病动态的分层证据中仍然存在严重缺陷,没有成文的协议来指导治疗应用。面对病理性疤痕导致的严重生活质量损害和加速的临床需求,未来的研究要求大规模前瞻性队列和长期监测,强调技术创新,先发制人的并发症管理和个性化治疗算法。本文提出的综合见解为当代循证实践提供了可操作的指导,并为疤痕治疗的未来技术发展提供了基础概念架构。
{"title":"Efficacy and Safety of Punch Excision Combined With Adjuvant Therapies for Hypertrophic Scars and Keloids: A Narrative Review","authors":"Qiang Fang,&nbsp;Xin Lin,&nbsp;Wen Liang,&nbsp;Weiming Qiu","doi":"10.1111/jocd.70622","DOIUrl":"10.1111/jocd.70622","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Pathological scars manifest as firm, elevated, erythematous plaques, or nodules after skin injury. As challenging wound-healing complications, hypertrophic scars and keloids significantly compromise aesthetics while causing functional impairment and psychosocial distress. Consequently, their management remains a central focus in dermatology. The skin punch has undergone substantial technical advancements, emerging as a promising therapeutic modality.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>To evaluate the efficacy of punch-based techniques in managing pathological scars, we conducted a comprehensive literature search using Boolean logic across electronic databases, with the core search strategy built upon the following terms: (“skin punch” OR “punch excision” OR “punch volume reduction”) AND (“pathological scar” OR “hypertrophic scar” OR “keloid”). Additional relevant studies were identified through citation tracking of the retrieved articles. This review systematically examines recent advancements in punch-assisted scar management, with particular focus on the mechanistic basis, diverse therapeutic modalities, clinical efficacy, and associated complications.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>This systematic appraisal of punch volume reduction for pathological scars affirms its robust efficacy in restoring aesthetic contour and functional integrity, while concurrently revealing substantial interpatient heterogeneity in therapeutic response and protracted convalescence intervals. Although the technique's clinical value is well-established, a critical deficit persists in stratified evidence across scar phenotypic spectra and temporal disease dynamics, with no codified protocols to direct therapeutic application. Confronted by the profound quality-of-life impairment attributable to pathological scars and accelerating clinical necessities, forthcoming research mandates large-scale prospective cohorts with prolonged surveillance, emphasizing technical innovation, preemptive complication management, and individualized treatment algorithms. The consolidated insights presented herein deliver both actionable guidance for contemporary evidence-based practice and a foundational conceptual architecture for future technological evolution in scar therapeutics.</p>\u0000 </section>\u0000 </div>","PeriodicalId":15546,"journal":{"name":"Journal of Cosmetic Dermatology","volume":"25 1","pages":""},"PeriodicalIF":2.5,"publicationDate":"2026-01-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jocd.70622","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145998369","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Assessment of Subepidermal Low-Echogenic Band via High-Frequency Ultrasound for Evaluating the Efficacy of Platelet-Rich Plasma Injection in Treating Facial Skin Photoaging: A Case Series 高频超声评价富血小板血浆注射治疗面部皮肤光老化的皮下低回声带疗效:一个病例系列。
IF 2.5 4区 医学 Q2 DERMATOLOGY Pub Date : 2026-01-19 DOI: 10.1111/jocd.70684
Wenjue Ye, Tong Liu, Wei Zhang, Sicheng Peng, Yong Liao

Background

Facial skin photoaging manifests as wrinkles, laxity, roughness, enlarged pores, telangiectasia, pigmentation, and dermal structural changes. Histologically, dermal collagen degradation and dermal-epidermal junction disruption form the subepidermal low-echogenic band (SLEB) on ultrasound. Platelet-rich plasma (PRP) injection promotes skin regeneration but lacks objective imaging biomarkers.

Objective

To objectively evaluate the structural efficacy of PRP for facial photoaging by quantifying SLEB width and dermal thickness changes via high-frequency ultrasound (HFUS), alongside skin analyzer assessments.

Methods

This retrospective case series included 10 patients (Glogau I–III) receiving three monthly PRP injections. The treatment utilized a standardized dual-step protocol: manual precision injection targeting the deep dermis, followed by mechanical mesogun injection for uniform superficial coverage. SLEB width and dermal thickness were measured at four facial sites using HFUS before and 1 month after treatment. A skin analyzer assessed skin parameters. A comprehensive clinical evaluation was conducted using the Glogau classification and Global Aesthetic Improvement Scale (GAIS) for efficacy and patient satisfaction assessment.

Results

Post-treatment, HFUS revealed significant reductions in SLEB width (average decrease 29%–47%, all p < 0.001) and increases in dermal thickness (average increase 24%–51%, all p ≤ 0.003). Skin analyzer showed significant improvements in Pores, Wrinkles, Brown Spots, and Red Areas (all p < 0.05). Clinical evaluations confirmed significant improvement in Glogau classification (p < 0.01) and high patient satisfaction (100% reported improvement on GAIS). No serious adverse events were observed; only transient erythema/edema and mild pain were reported.

Conclusion

HFUS is a reliable, non-invasive tool for assessing PRP efficacy. SLEB width reduction serves as a sensitive, objective imaging biomarker, providing structural evidence for PRP's ability to improve photoaging damage.

背景:面部皮肤光老化表现为皱纹、松弛、粗糙、毛孔粗大、毛细血管扩张、色素沉着和真皮结构改变。组织学上,真皮胶原降解和真皮-表皮连接处破坏形成皮下低回声带(SLEB)超声。富血小板血浆(PRP)注射促进皮肤再生,但缺乏客观的成像生物标志物。目的:通过高频超声(HFUS)量化SLEB宽度和真皮厚度变化,并结合皮肤分析仪评估,客观评价PRP治疗面部光老化的结构效果。方法:本回顾性病例系列包括10例(Glogau I-III)患者,每月接受3次PRP注射。治疗采用标准化的双步骤方案:手动精确注射针对真皮深层,然后机械中导枪注射均匀的表面覆盖。在治疗前和治疗后1个月,分别用HFUS测量面部4个部位SLEB宽度和真皮厚度。皮肤分析仪评估皮肤参数。采用Glogau分类和GAIS(全球审美改善量表)进行疗效和患者满意度的综合临床评价。结果:治疗后,HFUS显示SLEB宽度显著减少(平均减少29%-47%),均为p结论:HFUS是评估PRP疗效的可靠、无创工具。SLEB宽度减少是一种敏感、客观的成像生物标志物,为PRP改善光老化损伤的能力提供了结构证据。
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引用次数: 0
Early Detection of Monopolar Radiofrequency Tip Rupture Using Polarized Dermoscopy: A Preventive Approach Against Treatment-Related Burns 利用极化皮肤镜早期检测单极射频针尖破裂:预防治疗相关烧伤的一种方法。
IF 2.5 4区 医学 Q2 DERMATOLOGY Pub Date : 2026-01-18 DOI: 10.1111/jocd.70678
Shiou-Han Wang, Patricia Yu-Chun Peng, Hsien-Li Peter Peng

Background

Monopolar radiofrequency (MRF) devices use a capacitive membrane (CM) tip to deliver uniform heat to tissue. A peri-procedural CM rupture, while rare, risks causing thermoelectric burns.

Aims

To evaluate whether using polarized dermoscopy and preventive measures can detect CM ruptures early and prevent burns in MRF treatments.

Methods

We retrospectively reviewed all patients who underwent monopolar radiofrequency (MRF) treatment at a single dermatologic clinic between 2012 and 2024 and experienced a peri-procedural capacitive membrane (CM) rupture event. Non-contact polarized-dermoscopy-aided CM rupture detection and relevant preventive measures (cryogen checking, shaving, and patient education) were introduced since 2017. Clinical photographs were assessed by two board-certified dermatologists to verify thermoelectric burns.

Results

Among 13 cases of capacitive membrane (CM) rupture identified between 2012 and 2024, 8 ruptures were detected by naked-eye observation between 2012 and 2016, and all patients (8/8, 100%) developed thermoelectric burns. From 2017 onward, 5 ruptures were detected using non-contact polarized dermoscopy, and none of the associated patients (0/5, 0%) developed burns. This difference was statistically significant (p = 0.0008). In addition, the implementation of preventive measures—such as cryogen inspection and shaving protocols—was associated with a reduced number of CM rupture events (p = 0.0063).

Conclusions

Polarized dermoscopy, combined with preventive steps, enabled early detection of CM tip ruptures and prevented MRF-induced burns.

背景:单极射频(MRF)器件使用电容膜(CM)尖端向组织输送均匀的热量。术中CM破裂虽然罕见,但有引起热电灼伤的危险。目的:评价极化皮肤镜及预防措施在MRF治疗中是否能早期发现CM破裂及预防烧伤。方法:我们回顾性分析了2012年至2024年间在单一皮肤科诊所接受单极射频(MRF)治疗并经历了术中电容膜(CM)破裂事件的所有患者。自2017年以来,引入了非接触极化皮肤镜辅助CM破裂检测及相关预防措施(冷冻剂检查、剃须和患者教育)。临床照片由两名委员会认证的皮肤科医生评估,以验证热电烧伤。结果:2012 - 2024年发现的13例电容膜(CM)破裂病例中,2012 - 2016年裸眼观察发现8例,所有患者(8/8,100%)发生热电烧伤。自2017年起,使用非接触偏振皮肤镜检测到5例破裂,相关患者均未发生烧伤(0/ 5.0%)。差异有统计学意义(p = 0.0008)。此外,预防措施的实施,如冷冻检查和剃须方案,与减少CM破裂事件的数量有关(p = 0.0063)。结论:极化皮肤镜结合预防措施,可以早期发现CM尖端破裂,防止mrf引起的烧伤。
{"title":"Early Detection of Monopolar Radiofrequency Tip Rupture Using Polarized Dermoscopy: A Preventive Approach Against Treatment-Related Burns","authors":"Shiou-Han Wang,&nbsp;Patricia Yu-Chun Peng,&nbsp;Hsien-Li Peter Peng","doi":"10.1111/jocd.70678","DOIUrl":"10.1111/jocd.70678","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Monopolar radiofrequency (MRF) devices use a capacitive membrane (CM) tip to deliver uniform heat to tissue. A peri-procedural CM rupture, while rare, risks causing thermoelectric burns.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Aims</h3>\u0000 \u0000 <p>To evaluate whether using polarized dermoscopy and preventive measures can detect CM ruptures early and prevent burns in MRF treatments.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>We retrospectively reviewed all patients who underwent monopolar radiofrequency (MRF) treatment at a single dermatologic clinic between 2012 and 2024 and experienced a peri-procedural capacitive membrane (CM) rupture event. Non-contact polarized-dermoscopy-aided CM rupture detection and relevant preventive measures (cryogen checking, shaving, and patient education) were introduced since 2017. Clinical photographs were assessed by two board-certified dermatologists to verify thermoelectric burns.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Among 13 cases of capacitive membrane (CM) rupture identified between 2012 and 2024, 8 ruptures were detected by naked-eye observation between 2012 and 2016, and all patients (8/8, 100%) developed thermoelectric burns. From 2017 onward, 5 ruptures were detected using non-contact polarized dermoscopy, and none of the associated patients (0/5, 0%) developed burns. This difference was statistically significant (<i>p</i> = 0.0008). In addition, the implementation of preventive measures—such as cryogen inspection and shaving protocols—was associated with a reduced number of CM rupture events (<i>p</i> = 0.0063).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Polarized dermoscopy, combined with preventive steps, enabled early detection of CM tip ruptures and prevented MRF-induced burns.</p>\u0000 </section>\u0000 </div>","PeriodicalId":15546,"journal":{"name":"Journal of Cosmetic Dermatology","volume":"25 1","pages":""},"PeriodicalIF":2.5,"publicationDate":"2026-01-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jocd.70678","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145998339","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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Journal of Cosmetic Dermatology
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