Zhiyi Xu, Siqi Shen, Jingting Zhao, Jing Wang, Xinlan Wang, Li Gu, Shu Zhou, Jing Zhao, Liqun Gu, Lin Chen, Bingrong Zhou, Hui Hua
Background: Refractory rosacea can be effectively treated with fractional microneedle radiofrequency (FMR), but its optimal parameters need confirmation.
Objective: To explore the optimal parameters of FMR in treating rosacea-like dermatitis and the underlying mechanisms.
Methods: A rosacea-like dermatitis mouse model was intervened with FMR of varying pulse energy and width. By assessing the severity of erythema and measuring erythema area, optimal parameters of FMR to treat rosacea-like dermatitis in mice were determined. Pathological staining was performed to examine the infiltration of inflammatory cells and CD31+ microvessels. Expression levels of pro-inflammatory factors were detected by qRT-PCR. The involvement of the NF-κB signaling pathway and its downstream mediators (IL-1β, IL-6, TNF-α) in mice treated with low-power short-pulse-width fractional microneedle radiofrequency (LS-FMR) was detected using Western blotting. In a cohort of 20 patients with erythematotelangiectatic rosacea (ETR) and managed by one session of FMR treatment, therapeutic efficacy was assessed by Multispectral skin analysis system at 3 months of follow-up.
Results: LS-FMR at energy levels of 1, 2, 3 and 4 W and pulse width of 20 ms alleviated the severity of erythema and narrowed the erythema area in LL37-induced mice. It significantly inhibited the infiltration of mast cells and CD4+ T cells, polarization of CD4+ T cells to Th1/Th17 cells, angiogenesis, the activation of the NF-κB signaling pathway, as well as the expression of downstream inflammatory cytokines (IL-1β, IL-6, TNF-α). In a cohort of 20 ETR patients, just one session of FMR treatment significantly alleviated erythema at 3 months of follow-up, without obvious adverse events.
Conclusion: LS-FMR is a promising approach to treat rosacea by suppressing skin immune responses and angiogenesis.
Trial registration: Clinical trial number: Not applicable.
{"title":"Low-Power Short-Pulse-Width Fractional Microneedle Radiofrequency Relieves LL37-Induced Rosacea-Like Skin Inflammation.","authors":"Zhiyi Xu, Siqi Shen, Jingting Zhao, Jing Wang, Xinlan Wang, Li Gu, Shu Zhou, Jing Zhao, Liqun Gu, Lin Chen, Bingrong Zhou, Hui Hua","doi":"10.1111/jocd.70727","DOIUrl":"https://doi.org/10.1111/jocd.70727","url":null,"abstract":"<p><strong>Background: </strong>Refractory rosacea can be effectively treated with fractional microneedle radiofrequency (FMR), but its optimal parameters need confirmation.</p><p><strong>Objective: </strong>To explore the optimal parameters of FMR in treating rosacea-like dermatitis and the underlying mechanisms.</p><p><strong>Methods: </strong>A rosacea-like dermatitis mouse model was intervened with FMR of varying pulse energy and width. By assessing the severity of erythema and measuring erythema area, optimal parameters of FMR to treat rosacea-like dermatitis in mice were determined. Pathological staining was performed to examine the infiltration of inflammatory cells and CD31<sup>+</sup> microvessels. Expression levels of pro-inflammatory factors were detected by qRT-PCR. The involvement of the NF-κB signaling pathway and its downstream mediators (IL-1β, IL-6, TNF-α) in mice treated with low-power short-pulse-width fractional microneedle radiofrequency (LS-FMR) was detected using Western blotting. In a cohort of 20 patients with erythematotelangiectatic rosacea (ETR) and managed by one session of FMR treatment, therapeutic efficacy was assessed by Multispectral skin analysis system at 3 months of follow-up.</p><p><strong>Results: </strong>LS-FMR at energy levels of 1, 2, 3 and 4 W and pulse width of 20 ms alleviated the severity of erythema and narrowed the erythema area in LL37-induced mice. It significantly inhibited the infiltration of mast cells and CD4+ T cells, polarization of CD4+ T cells to Th1/Th17 cells, angiogenesis, the activation of the NF-κB signaling pathway, as well as the expression of downstream inflammatory cytokines (IL-1β, IL-6, TNF-α). In a cohort of 20 ETR patients, just one session of FMR treatment significantly alleviated erythema at 3 months of follow-up, without obvious adverse events.</p><p><strong>Conclusion: </strong>LS-FMR is a promising approach to treat rosacea by suppressing skin immune responses and angiogenesis.</p><p><strong>Trial registration: </strong>Clinical trial number: Not applicable.</p>","PeriodicalId":15546,"journal":{"name":"Journal of Cosmetic Dermatology","volume":"25 2","pages":"e70727"},"PeriodicalIF":2.5,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146149904","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Nicole Veltri, Michele Frank, Morgan Richter, Saulis Banionis, Julia Bifulco, Narendra Kumar
Background: Sequential monopolar-bipolar radiofrequency (RF) systems aim to provide multi-layer dermal heating for skin tightening and rejuvenation. Real-world outcome data for these devices remain limited.
Objectives: To evaluate the clinical efficacy, safety, and patient-reported outcomes of the DENSITY NOIR sequential RF device for aesthetic facial indications.
Methods: A retrospective multicentre case series was conducted across dermatology clinics in the United States. Consecutive patients who underwent DENSITY NOIR RF treatment and had standardized pre-and post-treatment photographs, along with follow-up surveys completed ≥ 30 days after treatment, were included in the study. Provider-rated improvement (4-point scale) and patient-reported outcomes, including visible improvement, satisfaction, pain, downtime, and likelihood to recommend, were summarized descriptively. Age-stratified subgroup analyses and correlation assessments were also performed.
Results: Twenty-five patients (88% female; age range 26-55 years) met the inclusion criteria. All demonstrated improvement from baseline; 56% showed moderate improvement, while 24% showed marked improvement. Patient satisfaction was high (100%), with 48% "very satisfied." Likelihood-to-recommend scores were strong (median 10/10). Downtime was minimal; 92% reported none. Age-subgroup analyses showed greater proportions of marked improvement and "very satisfied" responses among patients > 55 years. Pain scores were low, and no adverse events were recorded.
Conclusions: Sequential RF treatment demonstrated meaningful aesthetic improvement with excellent tolerability, high satisfaction, and negligible downtime. Findings support its value as a minimally invasive skin-rejuvenation option.
{"title":"Real-World Evaluation of Sequential Monopolar-Bipolar RF Device for Rejuvenation.","authors":"Nicole Veltri, Michele Frank, Morgan Richter, Saulis Banionis, Julia Bifulco, Narendra Kumar","doi":"10.1111/jocd.70687","DOIUrl":"https://doi.org/10.1111/jocd.70687","url":null,"abstract":"<p><strong>Background: </strong>Sequential monopolar-bipolar radiofrequency (RF) systems aim to provide multi-layer dermal heating for skin tightening and rejuvenation. Real-world outcome data for these devices remain limited.</p><p><strong>Objectives: </strong>To evaluate the clinical efficacy, safety, and patient-reported outcomes of the DENSITY NOIR sequential RF device for aesthetic facial indications.</p><p><strong>Methods: </strong>A retrospective multicentre case series was conducted across dermatology clinics in the United States. Consecutive patients who underwent DENSITY NOIR RF treatment and had standardized pre-and post-treatment photographs, along with follow-up surveys completed ≥ 30 days after treatment, were included in the study. Provider-rated improvement (4-point scale) and patient-reported outcomes, including visible improvement, satisfaction, pain, downtime, and likelihood to recommend, were summarized descriptively. Age-stratified subgroup analyses and correlation assessments were also performed.</p><p><strong>Results: </strong>Twenty-five patients (88% female; age range 26-55 years) met the inclusion criteria. All demonstrated improvement from baseline; 56% showed moderate improvement, while 24% showed marked improvement. Patient satisfaction was high (100%), with 48% \"very satisfied.\" Likelihood-to-recommend scores were strong (median 10/10). Downtime was minimal; 92% reported none. Age-subgroup analyses showed greater proportions of marked improvement and \"very satisfied\" responses among patients > 55 years. Pain scores were low, and no adverse events were recorded.</p><p><strong>Conclusions: </strong>Sequential RF treatment demonstrated meaningful aesthetic improvement with excellent tolerability, high satisfaction, and negligible downtime. Findings support its value as a minimally invasive skin-rejuvenation option.</p>","PeriodicalId":15546,"journal":{"name":"Journal of Cosmetic Dermatology","volume":"25 2","pages":"e70687"},"PeriodicalIF":2.5,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146149411","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}