Na Wang, Siming Wei, Shuai Qiang, Juan Wang, Xianhui Zeng, Zhaoxiang Zhang
Background
Poland syndrome is a rare congenital condition characterized by unilateral breast deformity. Autologous fat transplantation has emerged as the preferred treatment due to its minimal invasiveness, rapid recovery, absence of rejection reactions, and potential for multiple surgeries to enhance postoperative outcomes. Previous animal studies have shown that botulinum toxin significantly improves fat retention rates following fat transplantation. Therefore, we aim to initiate a clinical study to investigate the effects of botulinum toxin on human fat transplantation.
Objective
This prospective comparative clinical study aims to evaluate the impact of combining botulinum toxin with autologous fat grafting on fat retention rates in patients with Poland syndrome.
Method
From October 2017 to December 2023, we enrolled 20 Poland syndrome patients, assigning them to an experimental group receiving fat and botulinum toxin for breast augmentation and a control group undergoing standard autologous fat grafting. Postoperative fat retention rates were compared, and outcomes were assessed using the Breast-Q score, alongside baseline patient data.
Results
There were no significant differences in baseline data between the two groups. At 3 and 6 months postoperatively, the fat retention rate in the experimental group was significantly higher than that in the control group. Regarding Breast-Q scores, the control group exhibited significantly lower scores in the Satisfaction with breast domain than the experimental group, with no notable differences in other domains.
Conclusion
The injection of a mixture of fat and botulinum toxin significantly enhances fat retention rates in patients with isolated breast deformities associated with Poland syndrome.
Trial Registration
This study has been registered with the China Clinical Trial Center (ChiCTR2100054878)
{"title":"Autologous Fat Graft Combined With Botulinum Toxin Injection for Breast Augmentation in Poland Syndrome: A Prospective and Comparative Study","authors":"Na Wang, Siming Wei, Shuai Qiang, Juan Wang, Xianhui Zeng, Zhaoxiang Zhang","doi":"10.1111/jocd.70070","DOIUrl":"https://doi.org/10.1111/jocd.70070","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Poland syndrome is a rare congenital condition characterized by unilateral breast deformity. Autologous fat transplantation has emerged as the preferred treatment due to its minimal invasiveness, rapid recovery, absence of rejection reactions, and potential for multiple surgeries to enhance postoperative outcomes. Previous animal studies have shown that botulinum toxin significantly improves fat retention rates following fat transplantation. Therefore, we aim to initiate a clinical study to investigate the effects of botulinum toxin on human fat transplantation.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>This prospective comparative clinical study aims to evaluate the impact of combining botulinum toxin with autologous fat grafting on fat retention rates in patients with Poland syndrome.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Method</h3>\u0000 \u0000 <p>From October 2017 to December 2023, we enrolled 20 Poland syndrome patients, assigning them to an experimental group receiving fat and botulinum toxin for breast augmentation and a control group undergoing standard autologous fat grafting. Postoperative fat retention rates were compared, and outcomes were assessed using the Breast-Q score, alongside baseline patient data.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>There were no significant differences in baseline data between the two groups. At 3 and 6 months postoperatively, the fat retention rate in the experimental group was significantly higher than that in the control group. Regarding Breast-Q scores, the control group exhibited significantly lower scores in the Satisfaction with breast domain than the experimental group, with no notable differences in other domains.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>The injection of a mixture of fat and botulinum toxin significantly enhances fat retention rates in patients with isolated breast deformities associated with Poland syndrome.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Trial Registration</h3>\u0000 \u0000 <p>This study has been registered with the China Clinical Trial Center (ChiCTR2100054878)</p>\u0000 </section>\u0000 </div>","PeriodicalId":15546,"journal":{"name":"Journal of Cosmetic Dermatology","volume":"24 2","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-02-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jocd.70070","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143404580","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
To develop a sunscreen formula with spectral selectivity that filters harmful light (280–550 nm) while allowing beneficial light (550–760 nm) to permeate and thus to boost collagen generation.
Methods
A variety of sunscreen filters and their combinations were tested for transmittance spectrum. The spectral selectivity was quantified by Selection Index (SI), and the optimal formula was identified. Then, human dermal fibroblasts (HDFs) were subjected to simulated sunlight exposure with the application of this formula. The cell viability and collagen levels were measured post-exposure.
Results
The combination of TiO2 and FeO(OH)·H2O displays spectral selectivity and reaches the optimal SI value at the mixing ratio of 64:36. This mixture, when formulated with traditional UV filters, significantly elevates the level of Collagen I.
Conclusion
This work uncovers the influence of spectral selectivity on the enhancement of sunscreen performance and proposes a filter combination with spectral selectivity. This formula, when integrated with conventional UV sunscreens, allows for the beneficial effects of sunlight to be more pronounced. This discovery may provide fresh insights for the design of future sunscreen products.
{"title":"Sunscreen Formula of FeO(OH)·H2O/TiO2 With Spectral Selectivity to Enhance Collagen Biosynthesis via Fibroblast Test","authors":"Xun Zhang, Ximing Wen, Yuling Wang, Fangru Jiang, Yiting Chen, Zhe Liu","doi":"10.1111/jocd.70060","DOIUrl":"https://doi.org/10.1111/jocd.70060","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>To develop a sunscreen formula with spectral selectivity that filters harmful light (280–550 nm) while allowing beneficial light (550–760 nm) to permeate and thus to boost collagen generation.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>A variety of sunscreen filters and their combinations were tested for transmittance spectrum. The spectral selectivity was quantified by Selection Index (SI), and the optimal formula was identified. Then, human dermal fibroblasts (HDFs) were subjected to simulated sunlight exposure with the application of this formula. The cell viability and collagen levels were measured post-exposure.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>The combination of TiO<sub>2</sub> and FeO(OH)·H<sub>2</sub>O displays spectral selectivity and reaches the optimal SI value at the mixing ratio of 64:36. This mixture, when formulated with traditional UV filters, significantly elevates the level of Collagen I.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>This work uncovers the influence of spectral selectivity on the enhancement of sunscreen performance and proposes a filter combination with spectral selectivity. This formula, when integrated with conventional UV sunscreens, allows for the beneficial effects of sunlight to be more pronounced. This discovery may provide fresh insights for the design of future sunscreen products.</p>\u0000 </section>\u0000 </div>","PeriodicalId":15546,"journal":{"name":"Journal of Cosmetic Dermatology","volume":"24 2","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-02-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jocd.70060","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143396821","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
To develop a stable and efficient delivery system for baicalin, a flavonoid with potential antioxidant and antiaging properties, to overcome its limitations in solubility, stability, and skin permeability.
Methods
Baicalin was encapsulated using ATP synthase molecular motor technology into bio-vesicles derived from yeast/bacillus cell membranes, forming “motor baicalin” (MB). The liposome baicalin (LB), baicalin raw material (BRM), and bio-vesicles were used for comparison. The stability, transdermal penetration, and antioxidant activity of MB, LB, BRM, and bio-vesicles were evaluated through in vitro and in vivo tests.
Results
MB formed a stable core-shell structure, significantly enhancing the water solubility and long-term stability of baicalin. The tests confirmed superior transdermal penetration and antioxidant activity of MB, evidenced by increased expression of SOD, CAT, and GSH-Px enzymes and improved cell proliferation and migration. Clinical trials demonstrated significant reductions in wrinkle depth and improvements in skin elasticity.
Conclusion
This study presents a promising approach to improving the stability and transdermal delivery of baicalin. MB showcases potent antioxidant and antiaging properties, making it a valuable component in skincare products.
{"title":"Transdermal Delivery of Baicalin Based on Bio-Vesicles and Its Efficacy in Antiaging of the Skin","authors":"Liang Chen, Fudi Wang, Xiaoyun Hu, Nihong Li, Ying Gao, Fengfeng Xue, Ling Xie, Min Xie","doi":"10.1111/jocd.70024","DOIUrl":"https://doi.org/10.1111/jocd.70024","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>To develop a stable and efficient delivery system for baicalin, a flavonoid with potential antioxidant and antiaging properties, to overcome its limitations in solubility, stability, and skin permeability.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Baicalin was encapsulated using ATP synthase molecular motor technology into bio-vesicles derived from yeast/bacillus cell membranes, forming “motor baicalin” (MB). The liposome baicalin (LB), baicalin raw material (BRM), and bio-vesicles were used for comparison. The stability, transdermal penetration, and antioxidant activity of MB, LB, BRM, and bio-vesicles were evaluated through in vitro and in vivo tests.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>MB formed a stable core-shell structure, significantly enhancing the water solubility and long-term stability of baicalin. The tests confirmed superior transdermal penetration and antioxidant activity of MB, evidenced by increased expression of SOD, CAT, and GSH-Px enzymes and improved cell proliferation and migration. Clinical trials demonstrated significant reductions in wrinkle depth and improvements in skin elasticity.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>This study presents a promising approach to improving the stability and transdermal delivery of baicalin. MB showcases potent antioxidant and antiaging properties, making it a valuable component in skincare products.</p>\u0000 </section>\u0000 </div>","PeriodicalId":15546,"journal":{"name":"Journal of Cosmetic Dermatology","volume":"24 2","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-02-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jocd.70024","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143404604","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Eduarda Mazurkievz de Freitas, Kátia Sheylla Malta Purim
Background
Cycling is a practice that is increasing globally. However, there is a paucity of studies regarding sun protection usage among cyclists.
Methods
The present study uses a cross-sectional design. An online survey was conducted using the Google Forms platform, and a self-administered form was used to gather the participant's sociodemographic details, sporting practices, and sun protection usage habits. The full questionnaire file can be found as Supporting Information. Descriptive statistics were analyzed using Microsoft Excel, and the chi-square test of independence was performed to determine the association between the variables using a contingency table.
Results
The study sample comprised 379 cyclists, predominantly men (69.7%), and most cyclists were observed to be using some type of cycling-related application (81.3%). Approximately 67.3% of the cyclists used sunscreen. The sunscreen was applied once a day (45.4%), and the usage of sunscreen was lower in men (58%) and those with higher phototypes (69.2%). Furthermore, using long-sleeved shirts and sunglasses while cycling was 49.3% and 75.5% of the participants, respectively. Among the participants who did not use sun protection, 35% cycled for over 7 h a week.
Conclusion
The results indicate that cyclists must be encouraged to use sun protection, especially men and athletes with higher phototypes. Such use could be optimized in this population, associating the technologies related to the practice of cycling with health promotion.
{"title":"Sun Protection Used by Cyclists in Southern Brazil","authors":"Eduarda Mazurkievz de Freitas, Kátia Sheylla Malta Purim","doi":"10.1111/jocd.70049","DOIUrl":"https://doi.org/10.1111/jocd.70049","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Cycling is a practice that is increasing globally. However, there is a paucity of studies regarding sun protection usage among cyclists.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>The present study uses a cross-sectional design. An online survey was conducted using the Google Forms platform, and a self-administered form was used to gather the participant's sociodemographic details, sporting practices, and sun protection usage habits. The full questionnaire file can be found as Supporting Information. Descriptive statistics were analyzed using Microsoft Excel, and the chi-square test of independence was performed to determine the association between the variables using a contingency table.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>The study sample comprised 379 cyclists, predominantly men (69.7%), and most cyclists were observed to be using some type of cycling-related application (81.3%). Approximately 67.3% of the cyclists used sunscreen. The sunscreen was applied once a day (45.4%), and the usage of sunscreen was lower in men (58%) and those with higher phototypes (69.2%). Furthermore, using long-sleeved shirts and sunglasses while cycling was 49.3% and 75.5% of the participants, respectively. Among the participants who did not use sun protection, 35% cycled for over 7 h a week.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>The results indicate that cyclists must be encouraged to use sun protection, especially men and athletes with higher phototypes. Such use could be optimized in this population, associating the technologies related to the practice of cycling with health promotion.</p>\u0000 </section>\u0000 </div>","PeriodicalId":15546,"journal":{"name":"Journal of Cosmetic Dermatology","volume":"24 2","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-02-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jocd.70049","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143396819","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Lei Guo, Ping Xue, Xing Fan, Yue Yin, Wenjie Dou, Tong Li, Qing Yang
Background
Long linear scars in cross-sectional regions can adversely affect facial aesthetics and functionality, leading to substantial psychological distress. Early intervention with carbon dioxide ablative fractional laser (CO2-AFL) and 595-nm pulsed dye laser (PDL) has shown promise in mitigating post-surgical scarring. However, the effectiveness of this treatment for extensive facial scars across different areas remains unclear.
Methods
We reviewed medical records of 39 patients with long scars from facial trauma between January 2022 and October 2023. Treatment commenced with two sessions of PDL and three sessions of CO2-AFL 1 week post-suture removal. Outcomes were assessed using Antera 3D imaging and the Patient and Observer Scar Assessment Scale (POSAS 3.0). Quality of life improvements were measured using the Short Form-36 Health Survey (SF-36).
Results
All patients completed five sessions of laser treatment. Significant reductions were noted in Patient and Observer scores on the POSAS (p < 0.05). Antera 3D analysis revealed substantial improvements in average roughness, depression depth, and elevation depth across facial regions. The significance of improvements in color variation, texture elevation span, melanin hyperconcentration, and hemoglobin hyperconcentration varied by area. Patients also showed significant improvements in SF-36 scores for physical role limitations, social functioning, and emotional well-being compared to pre-treatment levels (p < 0.05).
Conclusions
Early sequential treatment with PDL and CO2-AFL effectively improves long scars in various facial areas.
{"title":"Efficiency of Early Sequential Laser Treatment for Facial Linear Scars in Cross-Sectional Regions","authors":"Lei Guo, Ping Xue, Xing Fan, Yue Yin, Wenjie Dou, Tong Li, Qing Yang","doi":"10.1111/jocd.70053","DOIUrl":"https://doi.org/10.1111/jocd.70053","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Long linear scars in cross-sectional regions can adversely affect facial aesthetics and functionality, leading to substantial psychological distress. Early intervention with carbon dioxide ablative fractional laser (CO<sub>2</sub>-AFL) and 595-nm pulsed dye laser (PDL) has shown promise in mitigating post-surgical scarring. However, the effectiveness of this treatment for extensive facial scars across different areas remains unclear.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>We reviewed medical records of 39 patients with long scars from facial trauma between January 2022 and October 2023. Treatment commenced with two sessions of PDL and three sessions of CO<sub>2</sub>-AFL 1 week post-suture removal. Outcomes were assessed using Antera 3D imaging and the Patient and Observer Scar Assessment Scale (POSAS 3.0). Quality of life improvements were measured using the Short Form-36 Health Survey (SF-36).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>All patients completed five sessions of laser treatment. Significant reductions were noted in Patient and Observer scores on the POSAS (<i>p</i> < 0.05). Antera 3D analysis revealed substantial improvements in average roughness, depression depth, and elevation depth across facial regions. The significance of improvements in color variation, texture elevation span, melanin hyperconcentration, and hemoglobin hyperconcentration varied by area. Patients also showed significant improvements in SF-36 scores for physical role limitations, social functioning, and emotional well-being compared to pre-treatment levels (<i>p</i> < 0.05).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Early sequential treatment with PDL and CO<sub>2</sub>-AFL effectively improves long scars in various facial areas.</p>\u0000 </section>\u0000 </div>","PeriodicalId":15546,"journal":{"name":"Journal of Cosmetic Dermatology","volume":"24 2","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-02-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jocd.70053","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143396820","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Raika Bourmand, Sofia E. Olsson, Shirin Soleimani, Arman Fijany
Background
The lip augmentation market is projected to reach a value of 11.6 billion USD by 2030. Hyaluronic acid (HA) fillers are the most common type due to biocompatibility and reversibility. However, there has been an increase in alternative procedures, such as the “lip flip,” involving the injection of botulinum neurotoxin A (BoNT-A) into the superior orbicularis oris muscle.
Aims
The purpose of this study is to review the current literature and evaluate the general public interest in dermal lip fillers compared to supralabial BoNT-A injections over the past decade.
Methods
The Google Trends database was used to collect relative monthly search volume for the terms “lip filler” and “lip flip” over a decade-long period (January 1, 2014–January 1, 2024). Google Trends data is automatically normalized with a value of 100 indicating maximal search volume and 1 indicating minimal search volume.
Results
Search volume for lip filler and lip flip increased similarly from 2014 to 2024. Lip filler was consistently more searched and had an average 75% increase in relative search volume per month. Meanwhile, “lip flip” had, on average, a 33% increase in search volume per month.
Conclusions
Although lip filler was more frequently inquired about than “lip flip,” the latter increased in popularity over time, reaffirming its popularity as a potential alternative to lip filler. Superior obicularis oris BoNT-A injections are rising in popularity and may be a valuable option for patients seeking cosmesis with hesitation toward dermal fillers.
{"title":"Lip Filler Versus “Lip Flip”: Longitudinal Public Interest and a Brief Review of Literature","authors":"Raika Bourmand, Sofia E. Olsson, Shirin Soleimani, Arman Fijany","doi":"10.1111/jocd.70048","DOIUrl":"https://doi.org/10.1111/jocd.70048","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>The lip augmentation market is projected to reach a value of 11.6 billion USD by 2030. Hyaluronic acid (HA) fillers are the most common type due to biocompatibility and reversibility. However, there has been an increase in alternative procedures, such as the “lip flip,” involving the injection of botulinum neurotoxin A (BoNT-A) into the superior orbicularis oris muscle.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Aims</h3>\u0000 \u0000 <p>The purpose of this study is to review the current literature and evaluate the general public interest in dermal lip fillers compared to supralabial BoNT-A injections over the past decade.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>The Google Trends database was used to collect relative monthly search volume for the terms “lip filler” and “lip flip” over a decade-long period (January 1, 2014–January 1, 2024). Google Trends data is automatically normalized with a value of 100 indicating maximal search volume and 1 indicating minimal search volume.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Search volume for lip filler and lip flip increased similarly from 2014 to 2024. Lip filler was consistently more searched and had an average 75% increase in relative search volume per month. Meanwhile, “lip flip” had, on average, a 33% increase in search volume per month.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Although lip filler was more frequently inquired about than “lip flip,” the latter increased in popularity over time, reaffirming its popularity as a potential alternative to lip filler. Superior obicularis oris BoNT-A injections are rising in popularity and may be a valuable option for patients seeking cosmesis with hesitation toward dermal fillers.</p>\u0000 </section>\u0000 </div>","PeriodicalId":15546,"journal":{"name":"Journal of Cosmetic Dermatology","volume":"24 2","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-02-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jocd.70048","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143389211","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
<p>Vitiligo is a chronic autoimmune disease characterized by skin depigmentation, affecting 0.5%–2% of the global population [<span>1</span>]. Patients often receive internal medications combined with local or systemic interventions, such as phototherapy, to regulate systemic immunity, improve the microenvironment of white spots, and inhibit lesion expansion [<span>2</span>]. Surgery is commonly employed for treating stable vitiligo [<span>3</span>]. Surgical procedures, such as skin grafts, microdrill grafts, and negative-pressure blister suction epidermal grafts, are typically restricted to smaller lesions and may cause cobblestone-like hyperpigmentation at the donor site [<span>4</span>]. ReCell is an epidermal cell transplantation technique used to treat stable, large-area vitiligo. It facilitates rapid regeneration and reepithelialization of the epidermis with an area expansion ratio of 20:1–80:1, depending on the treatment site [<span>5</span>]. Changes in the internal environment of skin lesions are critical to the effectiveness of surgical treatment and the subsequent repigmentation process. Narrow-band ultraviolet B (NB-UVB), a first-line phototherapy for vitiligo, supports surgical interventions by stimulating melanocyte proliferation, suppressing T lymphocytes, and inhibiting cytokines to create a favorable environment for transplanted melanocytes [<span>6</span>]. This study assessed the clinical efficacy of combining ReCell and NB-UVB in vitiligo patients.</p><p>The Ethics Committee of Chengdu Borun Vitiligo Hospital approved this study (2024BR-087-01) (Appendix S1). Written informed consent was obtained from all patients. Inclusion criteria included: ① meeting the diagnostic criteria for stable vitiligo as defined in the Vitiligo Diagnosis and Treatment Consensus (2021 edition) [<span>3</span>], ② no history of local or systemic glucocorticoid use within the past 6 months, and ③ a surgical treatment area exceeding 200 cm<sup>2</sup> in a single session. Criteria for stable vitiligo included: ① a vitiligo disease activity (VIDA) score of 0; ② clinical features such as porcelain-white spots with clear edges or residual pigmentation; ③ absence of isomorphic reactions for ≥ 1 year; and ④ under a Wood lamp, the affected skin area appeared smaller than the visually observed area. A total of 46 patients (21 males, 25 females; mean age: 23 years; age range: 15–48 years) were enrolled in the study. Patients were randomly assigned into two groups, with 23 patients in each. Both groups received ReCell treatment. The treatment group additionally underwent NB-UVB (Waldmann Company, Germany) irradiation starting 2 weeks postsurgery, at a frequency of twice per week. The initial dose was 300–400 mJ/cm<sup>2</sup>, with a 20% increment per treatment, for a total of 30 treatments [<span>7</span>].</p><p>Patients were followed up at 3 and 6 months postoperatively. Pigmentation was evaluated using photographs taken under a Wood's lamp, where fluoresce
{"title":"ReCell Combined With NB-UVB for the Treatment of Extensive Stable Vitiligo: A Randomized Controlled Trial","authors":"Xueya Tong, Zhiming Yuan, Yu Lei","doi":"10.1111/jocd.70032","DOIUrl":"https://doi.org/10.1111/jocd.70032","url":null,"abstract":"<p>Vitiligo is a chronic autoimmune disease characterized by skin depigmentation, affecting 0.5%–2% of the global population [<span>1</span>]. Patients often receive internal medications combined with local or systemic interventions, such as phototherapy, to regulate systemic immunity, improve the microenvironment of white spots, and inhibit lesion expansion [<span>2</span>]. Surgery is commonly employed for treating stable vitiligo [<span>3</span>]. Surgical procedures, such as skin grafts, microdrill grafts, and negative-pressure blister suction epidermal grafts, are typically restricted to smaller lesions and may cause cobblestone-like hyperpigmentation at the donor site [<span>4</span>]. ReCell is an epidermal cell transplantation technique used to treat stable, large-area vitiligo. It facilitates rapid regeneration and reepithelialization of the epidermis with an area expansion ratio of 20:1–80:1, depending on the treatment site [<span>5</span>]. Changes in the internal environment of skin lesions are critical to the effectiveness of surgical treatment and the subsequent repigmentation process. Narrow-band ultraviolet B (NB-UVB), a first-line phototherapy for vitiligo, supports surgical interventions by stimulating melanocyte proliferation, suppressing T lymphocytes, and inhibiting cytokines to create a favorable environment for transplanted melanocytes [<span>6</span>]. This study assessed the clinical efficacy of combining ReCell and NB-UVB in vitiligo patients.</p><p>The Ethics Committee of Chengdu Borun Vitiligo Hospital approved this study (2024BR-087-01) (Appendix S1). Written informed consent was obtained from all patients. Inclusion criteria included: ① meeting the diagnostic criteria for stable vitiligo as defined in the Vitiligo Diagnosis and Treatment Consensus (2021 edition) [<span>3</span>], ② no history of local or systemic glucocorticoid use within the past 6 months, and ③ a surgical treatment area exceeding 200 cm<sup>2</sup> in a single session. Criteria for stable vitiligo included: ① a vitiligo disease activity (VIDA) score of 0; ② clinical features such as porcelain-white spots with clear edges or residual pigmentation; ③ absence of isomorphic reactions for ≥ 1 year; and ④ under a Wood lamp, the affected skin area appeared smaller than the visually observed area. A total of 46 patients (21 males, 25 females; mean age: 23 years; age range: 15–48 years) were enrolled in the study. Patients were randomly assigned into two groups, with 23 patients in each. Both groups received ReCell treatment. The treatment group additionally underwent NB-UVB (Waldmann Company, Germany) irradiation starting 2 weeks postsurgery, at a frequency of twice per week. The initial dose was 300–400 mJ/cm<sup>2</sup>, with a 20% increment per treatment, for a total of 30 treatments [<span>7</span>].</p><p>Patients were followed up at 3 and 6 months postoperatively. Pigmentation was evaluated using photographs taken under a Wood's lamp, where fluoresce","PeriodicalId":15546,"journal":{"name":"Journal of Cosmetic Dermatology","volume":"24 2","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-02-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jocd.70032","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143389214","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
G. Ziade, R. Saade, D. Daou, D. Karam, A. Bendito, M. Tsintsadze
Background
Rhinoplasty is a prominent procedure in facial aesthetics, but extended surgical downtime remains its significant limitation. Nonsurgical rhinoplasty has gained popularity as an alternative, offering significant aesthetic improvements with minimal downtime. This study evaluates the clinical efficacy and safety of three nonsurgical rhinoplasty techniques combined, including hyaluronic acid (HA) filler, botulinum toxin type A (BTX), and barbed lifting threads.
Methods
A total of 85 patients were included into three groups: 63 subjects received HA filler and BTX injections, 9 subjects received barbed threads followed by BTX injections, and 13 received threads followed by HA filler and BTX injections. Patients assessed their satisfaction 1 month and a year posttreatment as well as adverse effects 48 h and 1 week after treatment using FACE-Q questionnaire for nose.
Results
Both 1 month and a year after treatment, the triple combination of barbed threads with HA filler and BTX demonstrated superior nose FACE-Q scores compared to the two other groups, showing highest patient satisfaction and minimal efficacy decay over time. No significant difference in FACE-Q scores was observed between the two groups receiving HA filler + BTX and barbed threads + BTX at either 1 month or a year posttreatment. Adverse effects were reported by subjects in all three groups 48 h posttreatment and completely resolved by 1 week after treatment.
Conclusion
Combining nonsurgical rhinoplasty techniques—such as lifting threads, HA fillers, and botulinum toxin—can deliver effective aesthetic improvements with minimal downtime. Among these, the triple combination of HA filler, BTX, and lifting threads results in the highest and most sustained patient satisfaction, lasting no less than 1 year.
{"title":"Nasal Reshaping Using Barbed Threads Combined With Hyaluronic Acid Filler and Botulinum Toxin A","authors":"G. Ziade, R. Saade, D. Daou, D. Karam, A. Bendito, M. Tsintsadze","doi":"10.1111/jocd.70047","DOIUrl":"https://doi.org/10.1111/jocd.70047","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Rhinoplasty is a prominent procedure in facial aesthetics, but extended surgical downtime remains its significant limitation. Nonsurgical rhinoplasty has gained popularity as an alternative, offering significant aesthetic improvements with minimal downtime. This study evaluates the clinical efficacy and safety of three nonsurgical rhinoplasty techniques combined, including hyaluronic acid (HA) filler, botulinum toxin type A (BTX), and barbed lifting threads.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>A total of 85 patients were included into three groups: 63 subjects received HA filler and BTX injections, 9 subjects received barbed threads followed by BTX injections, and 13 received threads followed by HA filler and BTX injections. Patients assessed their satisfaction 1 month and a year posttreatment as well as adverse effects 48 h and 1 week after treatment using FACE-Q questionnaire for nose.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Both 1 month and a year after treatment, the triple combination of barbed threads with HA filler and BTX demonstrated superior nose FACE-Q scores compared to the two other groups, showing highest patient satisfaction and minimal efficacy decay over time. No significant difference in FACE-Q scores was observed between the two groups receiving HA filler + BTX and barbed threads + BTX at either 1 month or a year posttreatment. Adverse effects were reported by subjects in all three groups 48 h posttreatment and completely resolved by 1 week after treatment.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Combining nonsurgical rhinoplasty techniques—such as lifting threads, HA fillers, and botulinum toxin—can deliver effective aesthetic improvements with minimal downtime. Among these, the triple combination of HA filler, BTX, and lifting threads results in the highest and most sustained patient satisfaction, lasting no less than 1 year.</p>\u0000 </section>\u0000 </div>","PeriodicalId":15546,"journal":{"name":"Journal of Cosmetic Dermatology","volume":"24 2","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-02-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jocd.70047","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143389212","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
<p>Generally, postinflammatory hyperpigmentation (PIH) from fixed drug eruptions (FDE) can resolve spontaneously [<span>1</span>]. However, various underlying factors may impede this process. Here, we present a complex patient with severe perioral hyperpigmentation due to FDE, who showed marked improvement after six sessions of intradermal tranexamic acid (TXA) injections.</p><p>A 50-year-old female patient presented with a 1-year persistent hyperpigmentation on her lips and perioral area after repeatedly taking Ibuprofen to manage fever during the COVID-19 pandemic. The pigmentation worsened with continued use of the medication (Figure 1A). Despite discontinuing ibuprofen and using topical hydroquinone and tretinoin for over 6 months, her hyperpigmentation became even more severe. A diagnosis of PIH caused by FDE was made. After discussing with her, we advised strict sun protection and avoidance of physical irritation of the lips. Additionally, we introduced intradermal injections of TXA due to its anti-inflammatory and anti-melanin-producing properties. The TXA solution was prepared by diluting 0.2 mL of a 500 mg/5 mL ampoule in sterile water to a 10 mg/mL concentration, yielding a total of 2 mL. The injections were administered intradermally at a 15°–20° angle, targeting the superficial dermis and creating small semicircular wheals. During each session, 0.1 mL doses were injected 5 mm apart across 14 sites, totaling 1.4 mL per session. After six monthly TXA sessions, the patient's perioral hyperpigmentation showed significant improvement (Figure 1B).</p><p>The type IV hypersensitivity reaction caused by FDE leads to damage to keratinocytes and melanocytes. Following drug withdrawal, dermal macrophages then phagocytize extravasated melanin, causing persistent PIH [<span>1</span>]. Basically, PIH from FDE is self-limiting [<span>1</span>]. However, in this case, the patient's hyperpigmentation not only failed to resolve but also worsened progressively after treatment. Hence, we considered there were additional factors that contributed to her atypical progression. First, her lesion is located on the lip, an area exposed to UV radiation and friction from eating. Second, she was in her perimenopausal period, also with skin type IV—a combination of skin type and fluctuating hormones that likely exacerbated her hyperpigmentation. Third, we can find that she also had melasma (Figure 1A), indicating a preexisting pigment metabolism abnormality. Collectively, factors such as UV exposure, mechanical friction, skin type, hormonal changes, and pigment metabolism issues likely intensified the pigmentation [<span>2</span>]. Therefore, for this patient, discontinuing the offending drug alone was insufficient; effective anti-inflammatory and antipigment treatments were necessary to counteract these ongoing factors contributing to persistent hyperpigmentation.</p><p>Topical treatments, such as retinoids, hydroxy acids, and broad-spectrum photoprotection, are th
{"title":"Intradermal Tranexamic Acid Injections: A Potential Therapy for Complex Cases of Drug-Induced Postinflammatory Hyperpigmentation","authors":"Juan He, Shinan Hou, Yi Yang","doi":"10.1111/jocd.70061","DOIUrl":"https://doi.org/10.1111/jocd.70061","url":null,"abstract":"<p>Generally, postinflammatory hyperpigmentation (PIH) from fixed drug eruptions (FDE) can resolve spontaneously [<span>1</span>]. However, various underlying factors may impede this process. Here, we present a complex patient with severe perioral hyperpigmentation due to FDE, who showed marked improvement after six sessions of intradermal tranexamic acid (TXA) injections.</p><p>A 50-year-old female patient presented with a 1-year persistent hyperpigmentation on her lips and perioral area after repeatedly taking Ibuprofen to manage fever during the COVID-19 pandemic. The pigmentation worsened with continued use of the medication (Figure 1A). Despite discontinuing ibuprofen and using topical hydroquinone and tretinoin for over 6 months, her hyperpigmentation became even more severe. A diagnosis of PIH caused by FDE was made. After discussing with her, we advised strict sun protection and avoidance of physical irritation of the lips. Additionally, we introduced intradermal injections of TXA due to its anti-inflammatory and anti-melanin-producing properties. The TXA solution was prepared by diluting 0.2 mL of a 500 mg/5 mL ampoule in sterile water to a 10 mg/mL concentration, yielding a total of 2 mL. The injections were administered intradermally at a 15°–20° angle, targeting the superficial dermis and creating small semicircular wheals. During each session, 0.1 mL doses were injected 5 mm apart across 14 sites, totaling 1.4 mL per session. After six monthly TXA sessions, the patient's perioral hyperpigmentation showed significant improvement (Figure 1B).</p><p>The type IV hypersensitivity reaction caused by FDE leads to damage to keratinocytes and melanocytes. Following drug withdrawal, dermal macrophages then phagocytize extravasated melanin, causing persistent PIH [<span>1</span>]. Basically, PIH from FDE is self-limiting [<span>1</span>]. However, in this case, the patient's hyperpigmentation not only failed to resolve but also worsened progressively after treatment. Hence, we considered there were additional factors that contributed to her atypical progression. First, her lesion is located on the lip, an area exposed to UV radiation and friction from eating. Second, she was in her perimenopausal period, also with skin type IV—a combination of skin type and fluctuating hormones that likely exacerbated her hyperpigmentation. Third, we can find that she also had melasma (Figure 1A), indicating a preexisting pigment metabolism abnormality. Collectively, factors such as UV exposure, mechanical friction, skin type, hormonal changes, and pigment metabolism issues likely intensified the pigmentation [<span>2</span>]. Therefore, for this patient, discontinuing the offending drug alone was insufficient; effective anti-inflammatory and antipigment treatments were necessary to counteract these ongoing factors contributing to persistent hyperpigmentation.</p><p>Topical treatments, such as retinoids, hydroxy acids, and broad-spectrum photoprotection, are th","PeriodicalId":15546,"journal":{"name":"Journal of Cosmetic Dermatology","volume":"24 2","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-02-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jocd.70061","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143389213","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Marina Landau, George Kroumpouzos, Mohamad Goldust
<p>Artificial intelligence (AI), particularly large language models (LLMs) like ChatGPT and Gemini, is expanding healthcare, specifically in the field of cosmetic dermatology. These advanced AI systems are designed to process and generate human-like text by analyzing vast amounts of data. Through natural language processing (NLP), LLMs offer innovative solutions that improve patient care, facilitate clinical workflows, and accelerate research efforts. However, while these models hold significant potential, it is crucial to address their limitations, as well as the ethical considerations and regulatory challenges associated with their use, to ensure responsible implementation [<span>1, 2</span>].</p><p>At their core, LLMs are sophisticated computer programs capable of understanding and generating human-like text. Imagine conversing with a knowledgeable assistant who can quickly summarize medical research, suggest treatment options, or answer complex questions. LLMs achieve this by learning patterns from extensive datasets, including books, articles, and scientific journals. With this training, they can synthesize information and provide coherent responses to user inquiries [<span>3</span>].</p><p>LLMs are expanding several aspects of cosmetic dermatology. One key application lies in patient education. By simplifying complex medical terminology, LLMs make cosmetic procedures, such as dermal fillers, neurotoxins, and laser therapies, more accessible to patients. This improved communication enables patients to make informed decisions about their care. Additionally, these tools have the potential to bridge knowledge gaps in underserved communities, although challenges like limited digital proficiency and internet access still persist.</p><p>Another critical application is personalized treatment planning. LLMs can analyze patient histories, procedural risks, and desired outcomes to provide evidence-based recommendations. For instance, they may suggest combining microneedling with platelet-rich plasma therapy to achieve optimal skin rejuvenation. While this personalization can enhance treatment outcomes, it requires clinician oversight to ensure that recommendations match individual patient needs and are free from bias.</p><p>LLMs also contribute to administrative efficiency in dermatology practices. Integrating these tools into electronic medical record (EMR) systems can automate tasks such as clinical note-taking, scheduling, and insurance coding. This automation reduces administrative burdens, allowing clinicians to devote more time to direct patient care [<span>4</span>].</p><p>Follow-up care and monitoring are additional areas where LLMs show efficiency. These models can interact with patients' postprocedure, ensuring adherence to recovery protocols, identifying potential complications, and assessing satisfaction levels. These capabilities enhance continuity of care and provide valuable feedback for clinicians to improve their services.</p><p>In tr
{"title":"Large Language Models in Cosmetic Dermatology","authors":"Marina Landau, George Kroumpouzos, Mohamad Goldust","doi":"10.1111/jocd.70044","DOIUrl":"https://doi.org/10.1111/jocd.70044","url":null,"abstract":"<p>Artificial intelligence (AI), particularly large language models (LLMs) like ChatGPT and Gemini, is expanding healthcare, specifically in the field of cosmetic dermatology. These advanced AI systems are designed to process and generate human-like text by analyzing vast amounts of data. Through natural language processing (NLP), LLMs offer innovative solutions that improve patient care, facilitate clinical workflows, and accelerate research efforts. However, while these models hold significant potential, it is crucial to address their limitations, as well as the ethical considerations and regulatory challenges associated with their use, to ensure responsible implementation [<span>1, 2</span>].</p><p>At their core, LLMs are sophisticated computer programs capable of understanding and generating human-like text. Imagine conversing with a knowledgeable assistant who can quickly summarize medical research, suggest treatment options, or answer complex questions. LLMs achieve this by learning patterns from extensive datasets, including books, articles, and scientific journals. With this training, they can synthesize information and provide coherent responses to user inquiries [<span>3</span>].</p><p>LLMs are expanding several aspects of cosmetic dermatology. One key application lies in patient education. By simplifying complex medical terminology, LLMs make cosmetic procedures, such as dermal fillers, neurotoxins, and laser therapies, more accessible to patients. This improved communication enables patients to make informed decisions about their care. Additionally, these tools have the potential to bridge knowledge gaps in underserved communities, although challenges like limited digital proficiency and internet access still persist.</p><p>Another critical application is personalized treatment planning. LLMs can analyze patient histories, procedural risks, and desired outcomes to provide evidence-based recommendations. For instance, they may suggest combining microneedling with platelet-rich plasma therapy to achieve optimal skin rejuvenation. While this personalization can enhance treatment outcomes, it requires clinician oversight to ensure that recommendations match individual patient needs and are free from bias.</p><p>LLMs also contribute to administrative efficiency in dermatology practices. Integrating these tools into electronic medical record (EMR) systems can automate tasks such as clinical note-taking, scheduling, and insurance coding. This automation reduces administrative burdens, allowing clinicians to devote more time to direct patient care [<span>4</span>].</p><p>Follow-up care and monitoring are additional areas where LLMs show efficiency. These models can interact with patients' postprocedure, ensuring adherence to recovery protocols, identifying potential complications, and assessing satisfaction levels. These capabilities enhance continuity of care and provide valuable feedback for clinicians to improve their services.</p><p>In tr","PeriodicalId":15546,"journal":{"name":"Journal of Cosmetic Dermatology","volume":"24 2","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-02-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jocd.70044","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143389280","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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