Journal of dentistry最新文献

{"title":"Synergistic effect of sodium fluoride and encapsulated calcium lactate on dental erosion-abrasion prevention","authors":"Sávio José Cardoso Bezerra ,&nbsp;Roberta Martins de Figueiredo ,&nbsp;Cláudia A. Kairalla ,&nbsp;Idalina Vieira Aoki ,&nbsp;Anderson T. Hara ,&nbsp;Taís Scaramucci","doi":"10.1016/j.jdent.2026.106503","DOIUrl":"10.1016/j.jdent.2026.106503","url":null,"abstract":"<div><h3>Objective</h3><div>This study aimed to encapsulate calcium ions in mesoporous silica coated with a polyelectrolyte multilayer, incorporate these particles into an experimental mouthrinse, and evaluate their potential to control dental erosion–abrasion.</div></div><div><h3>Methods</h3><div>Bovine enamel and dentin specimens were assigned to five groups: NaF (225 ppmF⁻), Ca²⁺ (encapsulated calcium), Ca+F (encapsulated calcium + NaF), F+Sn (225 ppmF⁻; 800 ppmSn²⁺), and Control (distilled water). Fluoride availability was measured using an ion-selective electrode. Specimens underwent a 5-day erosive–abrasive cycling model with citric acid challenges, brushing, and treatment with the assigned solutions. Surface loss (µm) was quantified by optical profilometry. Data were analyzed using one-way ANOVA and Tukey’s test (α = 5 %).</div></div><div><h3>Results</h3><div>Fluoride-containing solutions exhibited the expected ion availability, and no interaction between fluoride and encapsulated calcium was detected. In enamel, only F+Sn (4.81±0.13) significantly reduced surface loss compared to the Control (9.91±0.06) (p &lt; 0.001). In dentin, Ca+F (10.39±0.48) significantly reduced surface loss relative to the Control (12.07±1.33) (p = 0.014) and did not differ from F+Sn (9.10±1.29) (p = 0.095). NaF and Ca alone showed no significant protective effect for either substrate.</div></div><div><h3>Conclusions</h3><div>Mesoporous silica loaded with calcium, when combined with NaF, provided protection against dentin erosive wear but did not reduce enamel loss. Tin-containing formulations remained the most effective option for enamel.</div></div><div><h3>Clinical Significance</h3><div>A fluoride mouthrinse containing calcium encapsulated in mesoporous silica demonstrated protective potential for dentin under erosive–abrasive conditions, offering a promising tin-free alternative for individuals with dentin exposure requiring management of erosive tooth wear.</div></div>","PeriodicalId":15585,"journal":{"name":"Journal of dentistry","volume":"166 ","pages":"Article 106503"},"PeriodicalIF":5.5,"publicationDate":"2026-01-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145959597","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diagnostic accuracy of on-scan assessments compared to clinical assessments using a periodontal probe for detecting gingival recession: A cross-sectional study","authors":"N․E West ,&nbsp;M Wright ,&nbsp;S Daly ,&nbsp;R․G Newcombe ,&nbsp;M Davies ,&nbsp;M Kuralt ,&nbsp;N․X West","doi":"10.1016/j.jdent.2026.106504","DOIUrl":"10.1016/j.jdent.2026.106504","url":null,"abstract":"<div><h3>Aim</h3><div>Compare the diagnostic accuracy of measuring gingival recession (GR) using a digital ruler on intraoral scans with clinical measurements using a UNC-15 probe.</div></div><div><h3>Methods</h3><div>A prospective, observational, examiner-blinded, single-arm, cross-sectional, single-site study in adults aged 18+ with minimum of 20 teeth. All participants underwent an intraoral scan. Clinical GR was recorded on 6-sites (non-molar teeth) and 8-sites (molar teeth) by the principal examiner. Anonymised scans were assessed by the principal examiner twice (Ex1a, 1b) and two additional examiners (Ex2 and 3).</div></div><div><h3>Results</h3><div>109 participants were assessed; all had at least one site of buccal GR. Ex1a on-scan measurements compared to clinical measurements showed 66.9% sensitivity and 92.5% specificity. There were considerable differences between central and proximal sites, central sites showed greater sensitivity 77.0% and specificity 81.4% compared to proximal sites 38.5% and 97.2% respectively. Diagnostic precision was robust, agreement for intra-examiner variability (Examiner-1a vs 1b) was 98.5% (95% CI 98.1%-98.8%). Inter-examiner variability was 78.9% (95% CI, 77.0%-80.6%) for Ex-1a-Ex-2 and 86.2% (95% CI, 84.8%-87.5%) for Ex-1a-Ex-3.</div></div><div><h3>Conclusion</h3><div>Intraoral scan measurements are reproducible and can be utilised with accuracy. Measuring GR clinically is the current gold standard despite the limitations, intraoral scans can be utilised to overcome these limitations.</div></div>","PeriodicalId":15585,"journal":{"name":"Journal of dentistry","volume":"166 ","pages":"Article 106504"},"PeriodicalIF":5.5,"publicationDate":"2026-01-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145959565","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Polymeric coatings improve mechanical and biological properties of resin composites: An in vitro study","authors":"Seda Baktır ,&nbsp;Sezer Demirbuğa ,&nbsp;Hacer Balkaya ,&nbsp;Şengül Danışman ,&nbsp;Mustafa Serdar Önses ,&nbsp;Nusret Çelik","doi":"10.1016/j.jdent.2026.106350","DOIUrl":"10.1016/j.jdent.2026.106350","url":null,"abstract":"&lt;div&gt;&lt;h3&gt;Objective&lt;/h3&gt;&lt;div&gt;This study aimed to investigate the effects of polymeric coatings on the physical, chemical, and biological properties of resin composites (RCs).&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Methods&lt;/h3&gt;&lt;div&gt;A total of n = 10 RC discs were fabricated for each experimental group and coated with polydopamine (PDA), polyethylene glycol (PEG), or polyetheretherketone (PEEK) using a spin-coating technique. Three surface preparation protocols were applied: prior to polymerization, after polymerization with an oxygen-inhibition layer (OIL), and after polymerization without OIL. Surface characterization was performed using Scanning Electron Microscopy (SEM), Energy Dispersive X-ray Spectroscopy (EDX), X-ray Diffraction (XRD), and Fourier Transform Infrared Spectroscopy (FTIR). Oral fibroblast viability was evaluated using the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay at 24 h and 48 h. Scratch resistance, surface roughness, water contact angle, water sorption, solubility, and microhardness were also measured. Data normality was tested with the Shapiro–Wilk test. For normally distributed data, one-way and two-way analysis of variance (ANOVA) with Tukey’s HSD post-hoc test was applied. For non-normally distributed data, the Kruskal–Wallis test with Dunn’s post-hoc test or a two-way robust ANOVA with Bonferroni correction was performed. A significance level of &lt;em&gt;p&lt;/em&gt; &lt; 0.05 was considered statistically significant.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Results&lt;/h3&gt;&lt;div&gt;At 24 h, the post-polymerized PEEK group showed the highest cell viability, while PDA without OIL showed the lowest (&lt;em&gt;p&lt;/em&gt; &lt; 0.001). At 48 h, PDA without OIL exhibited the highest viability, whereas post-polymerized PDA showed the lowest (&lt;em&gt;p&lt;/em&gt; &lt; 0.001). PEEK coatings demonstrated the highest scratch resistance (&lt;em&gt;p&lt;/em&gt; = 0.035) and significantly improved microhardness (&lt;em&gt;p&lt;/em&gt; = 0.019). All coatings significantly reduced water contact angles, enhancing hydrophilicity (&lt;em&gt;p&lt;/em&gt; &lt; 0.05). No significant differences were found in water sorption and solubility. Surface roughness was influenced by the substrate, not the coating type.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Conclusions&lt;/h3&gt;&lt;div&gt;Within the limitations of this short-term in vitro study, spin-coated PEEK, PDA, and PEG coatings improved the mechanical, biological, and hydrolytic performance of RCs. Among these, PEEK conferred the greatest mechanical reinforcement, significantly enhancing scratch resistance and microhardness. PDA exhibited a distinct time-dependent biological effect, with reduced fibroblast adhesion at 24 h but markedly increased proliferation at 48 h, highlighting its dynamic bioactivity. PEG, although consistently associated with lower fibroblast adhesion due to its antifouling properties, contributed to enhanced surface hydrophilicity. Collectively, these findings indicate that polymeric surface coatings can beneficially modulate RC behavior; however, without standardized aging protocols ","PeriodicalId":15585,"journal":{"name":"Journal of dentistry","volume":"166 ","pages":"Article 106350"},"PeriodicalIF":5.5,"publicationDate":"2026-01-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145959538","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Advanced nanoparticle-based antibacterial delivery for endodontic disinfection: A systematic review and meta-analysis","authors":"Kanwalpreet Kaur ,&nbsp;Seerat Kaura ,&nbsp;Ravinder S Saini ,&nbsp;Maurya Manjunath ,&nbsp;Shashit Shetty Bavabeedu ,&nbsp;Mario Alberto Alarcón-Sánchez ,&nbsp;Javier Flores-Fraile ,&nbsp;Artak Heboyan","doi":"10.1016/j.jdent.2026.106347","DOIUrl":"10.1016/j.jdent.2026.106347","url":null,"abstract":"<div><h3>Objective</h3><div>This systematic review and meta-analysis aimed to evaluate advanced nanoparticle-based antibacterial delivery systems for endodontic disinfection, assessing their antibacterial efficacy and clinical applicability compared to conventional treatments.</div></div><div><h3>Materials and Methods</h3><div>A comprehensive database search (PubMed, Embase, Scopus, Web of Science, Cochrane Library, Google Scholar) identified relevant <em>in vitro, in vivo</em> and clinical studies published from January 2000 to April 2025. Study quality and risk of bias were assessed using RoB 2 and SYRCLE tools. Data were synthesized qualitatively and quantitatively via meta-analysis. PRISMA 2020 guidelines were strictly adhered to throughout.</div></div><div><h3>Results</h3><div>From 1150 initial records, 35 studies (28 <em>in vitro</em>, 4 animal, 3 clinical) were included in the qualitative synthesis, with 11 studies eligible for meta-analysis. Nanoparticle-based interventions significantly improved bacterial elimination compared to conventional methods (pooled OR 3.03, 95% CI: 1.02–8.98; <em>p</em> = 0.045), though heterogeneity was moderate (I² = 62%). Nanoparticles also demonstrated enhanced biofilm disruption, smear layer removal and deeper dentinal penetration relative to standard irrigants. Reported safety and biocompatibility profiles were favourable, though clinical data remain limited.</div></div><div><h3>Conclusion</h3><div>Nanoparticle-based disinfection systems offer significant advantages over conventional endodontic irrigants, particularly in biofilm penetration and sustained antibacterial efficacy. Although preliminary clinical findings are promising, further well-designed clinical trials are necessary to confirm long-term clinical effectiveness and safety.</div></div><div><h3>Clinical Significance</h3><div>Nanoparticle-based disinfectants offer a practical advantage in situations where conventional irrigants fall short, particularly in deep dentinal areas and mature biofilms. By improving bacterial elimination and enhancing penetration into complex canal anatomy, these systems may help reduce persistent infection and support more predictable endodontic outcomes. Their favourable biocompatibility also suggests potential as complementary agents within current clinical protocols.</div></div>","PeriodicalId":15585,"journal":{"name":"Journal of dentistry","volume":"166 ","pages":"Article 106347"},"PeriodicalIF":5.5,"publicationDate":"2026-01-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145952153","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Laboratory-based additive modifications in glass ionomer cements: A scoping review using a systematic data mining and trend analysis framework (2015-2024)","authors":"Kenta Tsuchiya ,&nbsp;Sharanbir K Sidhu ,&nbsp;Salvatore Sauro ,&nbsp;Jukka P. Matinlinna ,&nbsp;Hidehiko Sano ,&nbsp;Monica Yamauti ,&nbsp;Shuhei Hoshika ,&nbsp;James Kit Hon Tsoi ,&nbsp;Atsushi Tomokiyo","doi":"10.1016/j.jdent.2026.106349","DOIUrl":"10.1016/j.jdent.2026.106349","url":null,"abstract":"<div><h3>Objectives</h3><div>This scoping review aimed at identifying laboratory-based additive modifications in commercial glass ionomer cements (GICs), analyzing trends between additives and properties improved, and highlighting research gaps relevant to clinical performance using an expert-guided informatics framework (EGIF), a human-in-the-loop approach grounded in materials informatics (MI).</div></div><div><h3>Data/Sources</h3><div>Reporting followed the PRISMA Extension for Scoping Reviews. PubMed and ScienceDirect were screened from 01 January 2015 to 31 December 2024. Additional relevant articles were identified through reference mining.</div></div><div><h3>Study selection/Results</h3><div>A total of 1,222 articles were screened, and 79 unique records selected and further analyzed. Additives to GICs were categorized into nine classes according to MeSH classification. Based on the final selected articles, trends were analyzed regarding the GIC base materials used in experiments, the types of additives incorporated, and the properties improved. Research on GIC modification has been steadily increasing, with Fuji™ Ⅸ GP and Fuji™ Ⅱ LC being the most frequently used base materials. Recent studies have primarily focused on improving physicochemical properties while maintaining or even enhancing bioactivity.</div></div><div><h3>Conclusions</h3><div>EGIF based on these data suggests that the incorporation of nano-sized metals or bioactive glass or glass fiber may compensate for the limitations of commercially available GICs and enhance their bioactivity. Furthermore, AI-assisted approaches are expected to facilitate the prediction of the optimal additive and their ratios.</div></div><div><h3>Clinical significance</h3><div>This review provides an evidence-based map of additive strategies for GIC modification. As it synthesizes only in vitro findings, the results may guide rational development of next-generation GICs but do not directly reflect clinical outcomes.</div></div>","PeriodicalId":15585,"journal":{"name":"Journal of dentistry","volume":"166 ","pages":"Article 106349"},"PeriodicalIF":5.5,"publicationDate":"2026-01-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145952118","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An artificial intelligence-assisted automated quantitative evaluation system for condylar morphological changes of temporomandibular joint","authors":"Yuan Li ,&nbsp;Mu-Qing Liu ,&nbsp;Zi-Neng Xu ,&nbsp;Fang-Duan Ni ,&nbsp;Yang Xiao ,&nbsp;Hai-Long Bai ,&nbsp;Peng Ding ,&nbsp;Kai-Yuan Fu ,&nbsp;Jie Lei","doi":"10.1016/j.jdent.2026.106348","DOIUrl":"10.1016/j.jdent.2026.106348","url":null,"abstract":"<div><h3>Objectives</h3><div>To develop an artificial intelligence (AI)-assisted system for the automated quantitative evaluation of temporomandibular joint (TMJ) condylar morphological changes.</div></div><div><h3>Methods</h3><div>This study utilized 212 cone-beam computed tomography (CBCT) scans of the TMJ from 114 patients, with radiologist-validated annotations. The proposed system comprised three modules: (1) an automated segmentation model based on the U-Net architecture, trained on 120 TMJs (60 normal and 60 osteoarthritis condyles) and tested on 32 TMJs (16 normal, 8 type I osteoarthritis condyles with surface erosion/destruction, and 8 type II condyles with osteophyte formation, sclerosis, deformity, or cyst-like lesions); (2) an automated registration model using mutual information similarity, validated on 20 paired pre- and post-treatment TMJ scans of 10 patients with normal condyles; and (3) an automated quantitative measurement model for assessing condylar morphological changes based on anatomical landmarks. Segmentation accuracy was evaluated using the Dice similarity coefficient. Furthermore, pre- and post-treatment bilateral CBCT data from 10 patients with unilateral osteoarthritis were used to assess system accuracy. Consistency between automated and manual measurements was evaluated using the intra-class correlation coefficient. Additionally, time efficiency was assessed.</div></div><div><h3>Results</h3><div>The Dice similarity coefficient values for 16 normal, 8 type I, and 8 type II osteoarthritis condyles were 0.988, 0.986, and 0.981, respectively. The intraclass correlation coefficients of condyle and condylar head volumetric changes between the automated and manual methods were 0.983 and 0.995, respectively. The automated system completed measurements in 85 seconds versus 100 minutes for manual measurement.</div></div><div><h3>Conclusions</h3><div>The AI-assisted quantitative evaluation system demonstrated initial technical feasibility on a single-center CBCT dataset, providing an intuitive, user-friendly, and efficient assessment of the radiographic manifestations of condylar morphological changes. However, further validation using diverse cases is required.</div></div><div><h3>Clinical significance</h3><div>The TMJ condyle demonstrates active bone remodeling capacity, which is significantly influenced by clinical interventions such as prosthodontic treatment, orthodontic therapy, orthognathic surgery, and TMJ-related therapies. The proposed AI-assisted system facilitates rapid, objective quantification and three-dimensional visualization of condylar morphological changes. This dual functionality enables clinicians to evaluate disease progression and treatment effects on condylar morphological changes from radiographic perspectives.</div></div>","PeriodicalId":15585,"journal":{"name":"Journal of dentistry","volume":"166 ","pages":"Article 106348"},"PeriodicalIF":5.5,"publicationDate":"2026-01-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145952185","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Survival rate and prosthetic complications of short dental implants supporting implant overdentures: A systematic review and meta-analysis","authors":"Aspasia Pachiou ,&nbsp;Olga Naka ,&nbsp;Maria Sykara ,&nbsp;Nikitas Sykaras ,&nbsp;Panagiotis Tsirogiannis ,&nbsp;Daniel S Thoma ,&nbsp;Nadja Naenni","doi":"10.1016/j.jdent.2026.106351","DOIUrl":"10.1016/j.jdent.2026.106351","url":null,"abstract":"<div><h3>Objectives</h3><div>To evaluate the survival, marginal bone level changes (MBL), prosthetic complications, and patient-reported outcome measures (PROMs) of short dental implants (&lt;8 mm) supporting implant overdentures.</div></div><div><h3>Data</h3><div>Eight studies (3 RCTs, 5 prospective cohorts; 181 patients; 189 short implants) were synthesized.</div><div>Primary quantitative findings at 1 year:</div><div>Implant survival: 97.2% (95% CI, 93.1–98.9%; I² = 0%).</div><div>MBL: pooled mean 0.53 mm (95% CI, –0.20 to 1.27; I² = 95.8%).</div><div>Prosthetic complications: predominantly minor; 45.7% of patients experienced ≥1 maintenance event—most commonly matrix/insert replacement (24.7%) and relining (14.0%); overdenture fractures were uncommon (3.1%).</div><div>PROMs: consistently high satisfaction, but reporting was heterogeneous.</div><div>Certainty (GRADE): moderate for survival; low to very low for MBL, complications, and PROMs due to heterogeneity and imprecision.</div></div><div><h3>Sources</h3><div>Systematic review and meta-analysis conducted per PRISMA 2020 (PROSPERO CRD420251042692). Databases searched to May 2025: MEDLINE, Embase, and Scopus. Risk of bias assessed with RoB 2 (RCTs) and ROBINS-I V2 (cohorts). Quantitative synthesis used logit transformation with a Hartung–Knapp random-effects model for survival; inverse-variance random-effects model for MBL; and random-effects generalized linear mixed models (RE–GLMM) for complications. PROMs were narratively synthesized.</div></div><div><h3>Study selection</h3><div>Eligibility included randomized controlled trials and prospective clinical studies evaluating short dental implants (&lt;8 mm) supporting overdentures and reporting ≥1 target outcome (survival, MBL, prosthetic complications, PROMs). After screening and full-text assessment, 8 studies met the inclusion criteria and were included in the quantitative and/or qualitative synthesis.</div></div><div><h3>Conclusions</h3><div>Short implants supporting overdentures show high short-term survival, limited bone remodeling, and manageable maintenance demands, supporting their use where vertical bone height is limited. Long-term, adequately powered trials with standardized outcome reporting are needed to establish predictability over time.</div></div><div><h3>Clinical Significance</h3><div>Short implants supporting overdentures show high short-term survival, minimal bone remodeling, and manageable maintenance. They provide a practical option when vertical bone height is limited, reducing surgical procedures while maintaining patient satisfaction. Clinicians can consider them, acknowledging evidence is short term and standardized outcomes and robust follow-up remain necessary.</div></div>","PeriodicalId":15585,"journal":{"name":"Journal of dentistry","volume":"166 ","pages":"Article 106351"},"PeriodicalIF":5.5,"publicationDate":"2026-01-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145952171","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Artesunate-loaded hydrogel promotes osteogenic differentiation and bone regeneration under inflammation: An in vitro and in vivo study","authors":"Cuicui Zhao ,&nbsp;Xiaofei Dong ,&nbsp;Han Zhu ,&nbsp;Lingxue Gong ,&nbsp;Enkang Tong ,&nbsp;Rongrong Nie ,&nbsp;Xiangfeng Meng","doi":"10.1016/j.jdent.2026.106346","DOIUrl":"10.1016/j.jdent.2026.106346","url":null,"abstract":"<div><h3>Objective</h3><div>This study aimed to prepare an artesunate (AS)-loaded gelatin methacryloyl (AS/GelMA) composite hydrogel and systematically evaluate its anti-inflammatory and pro-osteogenic effects in a lipopolysaccharide (LPS)-induced inflammatory microenvironment.</div></div><div><h3>Methods</h3><div>The AS/GelMA hydrogel was prepared, and its physicochemical properties were characterized by scanning electron microscopy, Fourier-transform infrared spectroscopy, X-ray photoelectron spectroscopy, degradation, rheology, and compression tests. Biocompatibility was assessed by Cell Counting Kit-8, Live/Dead, and cytoskeleton staining, and anti-inflammatory and osteogenic activities were evaluated by quantitative real-time polymerase chain reaction, western blot, immunofluorescence, and Alizarin Red S staining of rat bone marrow mesenchymal stem cells (rBMSCs) under LPS-induced inflammation. <em>In vivo</em> rat mandibular inflammatory defect models were constructed and assessed at two and four weeks post-surgery using micro-computed tomography and histological staining.</div></div><div><h3>Results</h3><div>The addition of AS enhanced the hydrogel's mechanical strength while maintaining its biocompatibility, interconnected porous structure, and injectability. <em>In vitro</em>, the AS/GelMA hydrogel significantly inhibited the expression of pro-inflammatory factors and significantly promoted osteogenic differentiation and mineralization under inflammation. <em>In vivo</em>, the AS/GelMA group showed no obvious visceral toxicity and accelerated higher-quality new bone formation at two and four weeks compared to controls.</div></div><div><h3>Conclusions</h3><div>The AS/GelMA composite hydrogel effectively coordinated dual anti-inflammatory and pro-osteogenic bioactivities, significantly promoting the repair of inflammatory bone defects. Therefore, AS/GelMA represents a promising biomaterial strategy to improve regenerative outcomes under inflammation-compromised conditions.</div></div><div><h3>Clinical significance</h3><div>The AS/GelMA hydrogel promoted the repair of mandibular inflammatory bone defects in rats by coordinating anti-inflammatory and pro-osteogenic activities. This offers a promising biomaterial strategy for addressing residual inflammation-related bone loss in oral and maxillofacial surgery.</div></div>","PeriodicalId":15585,"journal":{"name":"Journal of dentistry","volume":"166 ","pages":"Article 106346"},"PeriodicalIF":5.5,"publicationDate":"2026-01-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145948710","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Erratum to “Multidimensional oral frailty scale developed through an international e-Delphi approach” [Journal of Dentistry 165 (2026)/106276]","authors":"Keerthika Natarajan ,&nbsp;Mun Loke Wong ,&nbsp;Matthew Zhixuan Chen ,&nbsp;Gabriel Keng Yan Lee ,&nbsp;Mei Na Tan ,&nbsp;Xiaoli Gao","doi":"10.1016/j.jdent.2025.106324","DOIUrl":"10.1016/j.jdent.2025.106324","url":null,"abstract":"","PeriodicalId":15585,"journal":{"name":"Journal of dentistry","volume":"166 ","pages":"Article 106324"},"PeriodicalIF":5.5,"publicationDate":"2026-01-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145944230","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Multi-Architecture deep learning for CBCT segmentation of dental hard tissues and pulp in mixed dentition","authors":"Marwa Baraka ,&nbsp;Elbadry Elbadry ,&nbsp;Omer Abourida ,&nbsp;AbdulMajid Albaradi ,&nbsp;Youmna Wagih ,&nbsp;Mahmoud Gamal ,&nbsp;Marwan Torki","doi":"10.1016/j.jdent.2026.106344","DOIUrl":"10.1016/j.jdent.2026.106344","url":null,"abstract":"<div><h3>Objective</h3><div>To develop and evaluate deep learning-based 3D models (CNN, Transformer, and Mamba architectures) for automated segmentation of pulp, primary, and permanent dental structures in pediatric CBCT scans with mixed dentition.</div></div><div><h3>Methods</h3><div>A total of 151 CBCT scans were analyzed, comprising 105 internal dataset scans(29,478 images) and 46 external scans. Expert-annotated internal data were used for model development with 78 for training/validation and 27 for testing. Fully supervised multi-task models were trained to segment pulp, primary and permanent hard tissue structures. Six architectures (ResEncM, U-Mamba Bot/Enc, WNet, UNETR, SegResNet) were evaluated using DSC, IoU, HD95, segmentation volume, and processing time.</div></div><div><h3>Results</h3><div>Within the internal dataset, 3D_fullres ResEncM achieved the highest accuracy across structures and age groups. Permanent teeth were segmented most reliably (ages 6–9: DSC 0.9859 ± 0.0086, HD95 0.2035 ± 0.0925; ages 10–13: DSC 0.9825 ± 0.0100, HD95 0.2825 ± 0.0525), while primary teeth were less accurate, particularly in older children (10–13 years: DSC 0.8855 ± 0.1557, HD95 4.4201 ± 6.5116). U-Mamba Bot and U-Mamba Enc performed well, with U-Mamba Bot excelling in pulp segmentation and U-Mamba Enc in primary structures. WNet, UNETR, and SegResNet were less consistent, especially for primary teeth in older children. In external validation, ResEncM maintained the highest DSC (0.8464 ± 0.1226) and lowest HD95 (4.9078 ± 4.9058). All models showed no significant volume bias (<em>p</em> &gt; 0.05) and high volumetric correlations (ρ ≥ 0.997). UNETR was fastest (0.48 ± 0.38 min), followed by U-Mamba Bot (0.60 ± 0.40 min).</div></div><div><h3>Conclusion</h3><div>nnU-Net ResEncM showed the strongest overall performance, while U-Mamba Bot and U-Mamba Enc excelled in pulp and primary-tooth segmentation. All three models performed well across age groups, with primary tooth segmentation more accurate in younger children. External testing confirmed adequate performance, though lower than on the internal dataset, supporting the feasibility of automated CBCT segmentation.</div></div><div><h3>Clinical Significance</h3><div>Automated segmentation of pulp and hard dental structures can streamline CBCT assessment and enhance workflow efficiency in managing developing teeth and complex orthodontic or surgical cases. This study provides a framework for incorporating AI-assisted analysis into pediatric dental imaging by including both primary and developing permanent dentition, as well as anomalous cases.</div></div>","PeriodicalId":15585,"journal":{"name":"Journal of dentistry","volume":"166 ","pages":"Article 106344"},"PeriodicalIF":5.5,"publicationDate":"2026-01-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145948736","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}