Journal of dentistry最新文献

{"title":"Validation of a novel tool for automated tooth modelling by fusion of CBCT-derived roots with the respective IOS-derived crowns","authors":"Benedetta Baldini ,&nbsp;Dhanaporn Papasratorn ,&nbsp;Fernanda Bulhões Fagundes ,&nbsp;Rocharles Cavalcante Fontenele ,&nbsp;Reinhilde Jacobs","doi":"10.1016/j.jdent.2024.105546","DOIUrl":"10.1016/j.jdent.2024.105546","url":null,"abstract":"<div><h3>Objectives</h3><div>To validate a novel artificial intelligence (AI)-based tool for automated tooth modelling by fusing cone beam computed tomography (CBCT)-derived roots with corresponding intraoral scanner (IOS)-derived crowns.</div></div><div><h3>Methods</h3><div>A retrospective dataset of 30 patients, comprising 30 CBCT scans and 55 IOS dental arches, was used to evaluate the fusion model at full arch and single tooth levels. AI-fused models were compared with CBCT tooth segmentation using point-to-point surface distances—reported as median surface distance (MSD), root mean square distance (RMSD), and Hausdorff distance (HD)— alongside visual assessments. Qualitative assessment included visual inspection of CBCT multiplanar views. The automated fused model was also compared to expert-manual fusions for single tooth analysis in terms of accuracy, time efficiency, and consistency.</div></div><div><h3>Results</h3><div>AI-based fusion evaluation showed mean values of MSD, RMSD, and HD of 4 μm, 114 μm, and 940 μm for full arch; 5 μm, 104 μm, and 503 μm for single tooth analysis. Qualitative assessment showed discrepancies between fused tooth outline and CBCT tooth margin lower than 1 voxel for 59% of cases. AI-based fusion showed high similarity with expert-manual fusions with median MSD, RMSD, and HD values of 28 μm, 104 μm, and 576 μm, respectively. However, AI-based fusion was 32 times faster than manual fusion. Considering the time required for manual fusion, intra-observer agreement was high (ICC 0.93), while inter-observer agreement was moderate (ICC 0.48).</div></div><div><h3>Conclusion</h3><div>The AI-based CBCT/IOS fusion demonstrated clinically acceptable accuracy, efficiency, and consistency, offering substantial time savings and robust performance across different patients and imaging devices.</div></div><div><h3>Clinical significance</h3><div>Manual CBCT/IOS fusion performed by experts is effective but labor-intensive and time-consuming. AI algorithms show a remarkable ability to minimize human variability, resulting in more reliable and efficient fusion. This capability demonstrates the potential to provide a more personalized, precise and standardized approach for treatment planning and dental procedures.</div></div>","PeriodicalId":15585,"journal":{"name":"Journal of dentistry","volume":"153 ","pages":"Article 105546"},"PeriodicalIF":4.8,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142915030","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Load-bearing capacity of screw-retained fixed dental prostheses made of monolithic zirconia on different abutment designs and abutment-free implant connection","authors":"Tobias Schäfer ,&nbsp;Kiren J Mätzener ,&nbsp;Ronald E Jung ,&nbsp;Mutlu Özcan ,&nbsp;Jenni Hjerppe","doi":"10.1016/j.jdent.2025.105561","DOIUrl":"10.1016/j.jdent.2025.105561","url":null,"abstract":"<div><h3>Objectives</h3><div>A new abutment-free implant connection allows for direct screwing of FDPs on implants to avoid complications caused by cement rests or screw loosening, which may affect to screw torque and load distribution. The objective of this study was to test the initial (Fi) and final failure (Ff) loads and torque changes of abutment-free monolithic zirconia CAD-CAM fixed dental prostheses (FDPs) compared to titanium FDPs on different abutment designs.</div></div><div><h3>Methods</h3><div>Three-unit screw-retained FDPs (<em>n</em> = 50) on two implants (<em>n</em> = 100) were divided into groups (<em>n</em> = 10) based on the implant-abutment connection and material of the supra-structure: (1) abutment-free monolithic CAD-CAM zirconia FDP (Abut-free-Zr), (2) abutment-free veneered titanium FDPs (Abut-free-Ti), (3) monolithic zirconia FDPs with titanium base abutments (Zr-Ti-Base), (4) monolithic zirconia FDPs on multi-unit abutments (Zr-MU), (5) veneered titanium FDP on multi-unit abutments (Ti-MU). All specimens were subjected to thermo-mechanical aging (1′200’000 Cycles, 49 N, 1.67 Hz, 5º to 50º C, dwelling time 120 s). Torque of the screws was measured, and static loading was performed. Data were tested using ANOVA and Tukey's tests (<em>p</em> &lt; 0.05).</div></div><div><h3>Results</h3><div>After thermo-mechanical aging, all screws showed reduced torque, Ti-MU significantly more reduction compared to Abut-Free-Ti (<em>p</em> = 0.0021). Titanium groups showed significantly lower Fi (N) values (171.4–230 vs 1272–1358,) due to veneering porcelain fractures (<em>p</em> = 0.0001) and significantly higher Ff (N) (2922 –3029 N vs. 1272–1358) values than zirconia groups (<em>p</em> &lt; 0.0001).</div></div><div><h3>Conclusions</h3><div>Three-unit abutment-free monolithic zirconia FPDs showed similar failure loads compared to other zirconia groups, while the titanium groups exhibited superior final failure loads. Different abutment designs did not seem to affect the failure loads.</div></div><div><h3>Clinical Significance</h3><div>The specific design of the novel implant interface allows for the fabrication of implant supported FDPs with personalized design directly on implant level without abutments. The monolithic zirconia FDPs on abutment-free implant connection can be used with good confidence since they exhibit similar mechanical stability as monolithic zirconia FDPs on titanium-base or multi-unit abutments.</div></div>","PeriodicalId":15585,"journal":{"name":"Journal of dentistry","volume":"153 ","pages":"Article 105561"},"PeriodicalIF":4.8,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142949876","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Accuracy of digital and conventional implant impressions in edentulous jaws: A clinical comparative study","authors":"A. Kernen-Gintaute ,&nbsp;M. Akulauskas ,&nbsp;F. Kernen ,&nbsp;N.U. Zitzmann ,&nbsp;B.C. Spies ,&nbsp;F. Burkhardt","doi":"10.1016/j.jdent.2025.105559","DOIUrl":"10.1016/j.jdent.2025.105559","url":null,"abstract":"<div><h3>Objectives</h3><div>This clinical study aimed to evaluate the accuracy of digital and conventional implant impressions in a fully edentulous maxilla and mandible.</div></div><div><h3>Methods</h3><div>A 53-year-old edentulous patient with four maxillary and two mandibular implants was selected. Ten intraoral scans (IOS) and a conventional impression per jaw were taken. Clinically verified upper and lower plaster models were digitized using both optical (reference data, <em>n</em> = 10 per model) and tactile laboratory scanner (<em>n</em> = 10 per model). Accuracy was evaluated by comparing the precision and linear/angular deviations of the implants with the reference data. Statistical analyses were conducted using Student's <em>t</em>-test and Kruskal–Wallis test (<em>α</em> = 0.05).</div></div><div><h3>Results</h3><div>In the maxilla, the most significant linear deviations exceeding the 100 µm threshold were found with IOS between implants 1–4. In the mandible, all linear deviations remained below 55 µm. Angular deviations between implants after IOS ranged from 0.01° to 0.40° in the mandible and &lt;0.01° to 1.86° in the maxilla. After tactile scanning, linear deviations did not exceed 100 µm threshold (except in one distance) and angular deviations ranged from 0.04° to 0.54° (mandible) and &lt;0.01° to 2.50° (maxilla). The optical scanner demonstrated significantly higher precision (<em>p</em> &lt; 0.001) compared to the IOS and tactile scanner.</div></div><div><h3>Conclusions</h3><div>Given the significant deviations observed, especially in the maxilla, the optical scanner following conventional impressions remained the preferred method for fully edentulous cases due to its superior accuracy.</div></div><div><h3>Clinical significance</h3><div>IOS could be a viable alternative particularly for shorter distances in the edentulous jaw, although the clinical implications of these deviations need to be investigated in future studies.</div></div>","PeriodicalId":15585,"journal":{"name":"Journal of dentistry","volume":"153 ","pages":"Article 105559"},"PeriodicalIF":4.8,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142962010","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between non-carious cervical lesions, dentin hypersensitivity and anxiety in young adults: A cross-sectional study","authors":"Roberto Zimmer ,&nbsp;Gustavo Frainer Barbosa ,&nbsp;Fernando Freitas Portella ,&nbsp;Paulo Vinícius Soares ,&nbsp;Eduardo Galia Reston","doi":"10.1016/j.jdent.2025.105563","DOIUrl":"10.1016/j.jdent.2025.105563","url":null,"abstract":"<div><h3>Objectives</h3><div>To investigate the prevalence and factors associated with dentin hypersensitivity (DH) and non-carious cervical lesions (NCCLs).</div></div><div><h3>Methods</h3><div>The analytical cross-sectional study included 157 participants aged between 18 and 45 years, who were clinically examined and answered a questionnaire related to their lifestyle and daily habits (diet, parafunctional habits, temporomandibular disorders, general and oral health) and the Beck Anxiety Inventory. A descriptive analysis of the prevalence of DH and NCCL was performed, both at the individual level and considering the distribution among the teeth. Poisson regression models were used to investigate factors associated with hypersensitivity.</div></div><div><h3>Results</h3><div>The prevalence of DH and NCCL was 84.7 % and 49.7 %, respectively. The use of whitening toothpaste and brushing teeth immediately after meals were related to the presence of at least one tooth with DH, while the NCCL and anxiety factors were related to the presence of DH in both at least one tooth and more than four teeth per individual. On the other hand, individuals who used soft and extra soft toothbrushes, as well as those who had knowledge about oral health, had a lower prevalence of DH.</div></div><div><h3>Conclusions</h3><div>DH and NCCL have a high prevalence in the population and are associated with each other and with the individual's lifestyle and habits.</div></div><div><h3>Clinical significance</h3><div>Individuals with signs of anxiety had a higher prevalence of DH, while individuals with knowledge about the etiological factors had a lower prevalence of the disease.</div></div>","PeriodicalId":15585,"journal":{"name":"Journal of dentistry","volume":"153 ","pages":"Article 105563"},"PeriodicalIF":4.8,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142965505","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Feasibility, trueness and precision of intraoral scanners in digitizing maxillectomy defects with exposed zygomatic implants in situ: An in vitro 3D comparative study","authors":"Mahmoud E. Elbashti ,&nbsp;Adrien Naveau ,&nbsp;Benedikt Spies ,&nbsp;Anna-Lena Hillebrecht ,&nbsp;Samir Abou-Ayash ,&nbsp;Martin Schimmel ,&nbsp;Juan López-Quiles ,&nbsp;Pedro Molinero-Mourelle","doi":"10.1016/j.jdent.2025.105557","DOIUrl":"10.1016/j.jdent.2025.105557","url":null,"abstract":"<div><h3>Objectives</h3><div>To in-vitro evaluate the feasibility and accuracy (trueness and precision) of various intraoral scanners (IOS) to digitize maxillectomy defect models with exposed zygomatic implants in situ.</div></div><div><h3>Material and Methods</h3><div>Six partially edentulous and edentulous maxillectomy defect models with 2 zygomatic implants each were obtained. References scans were obatined by using a laboratory scanner (inEos X5; Dentsply Sirona). Three IOS, Trios 3, Trios 4 (3Shape A/S), and Primescan (Dentsply Sirona) were used first to digitize the entire model including implants and then to only scan the exposed part of zygomatic implants. The feasibility was assessed by evaluating the intraoral scanner's ability to accurately capture the maxillectomy defects and zygomatic implants, compared to a reference standard. Trueness and precision were evaluated using software's global best-fit alignment (GOM Inspect, GOM GmbH). Multifactorial analysis of variance (ANOVA) was used to compare the mean 3D deviation according to different scanners, groups, and model types. The significance level used in the analyses was 5 % (α=0.05).</div></div><div><h3>Results</h3><div>All scanners showed adequate feasibility to scan the entire maxillectomy defects and exposed implants regardless of the structural complexity. The results of trueness showed that Primescan has the smallest 3D deviations (0.0252 mm) followed by Trios 4 (0,0275 mm), and then Trios 3 (0.0318 mm) (<em>p</em> &lt; 0.001). The results of precision showed that Primescan had the smallest 3D deviations (0.0026 mm) followed by Trios 3 (0,0080 mm), and then Trios 4 (0,0097 mm) (<em>p</em> &lt; 0.001).</div></div><div><h3>Conclusion</h3><div>Intraoral scanners differ in feasibility, trueness and accuracy of all scans, with Primescan providing the best combination of feasibility, trueness and accuracy, followed by Trios 4 and Trios 3.</div></div><div><h3>Clinical Significance</h3><div>Scanning maxillectomy defects with various exposed zygomatic implants can be feasible and accurate using intraoral scanners (Trios 3, Trios 4, and Primescan). The use of intraoral scanners for implant-prosthetic rehabilitation of maxillectomy defect can be a feasible alternative that can improve and simplify the workflow.</div></div>","PeriodicalId":15585,"journal":{"name":"Journal of dentistry","volume":"153 ","pages":"Article 105557"},"PeriodicalIF":4.8,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142971057","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of manufacturing trinomial and restoration thickness on the fabrication trueness, fit, and margin quality of additively manufactured resin-based ultrathin laminate veneers.","authors":"Münir Demirel, Mustafa Borga Donmez, Gülce Çakmak, Doğu Ömür Dede, Sebastian Hinz, Burak Yilmaz","doi":"10.1016/j.jdent.2025.105606","DOIUrl":"https://doi.org/10.1016/j.jdent.2025.105606","url":null,"abstract":"<p><strong>Objective: </strong>To evaluate the effect of the manufacturing trinomial (manufacturing technology, three-dimensional printer, and material) and restoration thickness on the fabrication trueness, fit, and margin quality of additively manufactured resin-based ultrathin laminate veneers (LVs) by comparing to those produced subtractively.</p><p><strong>Methods: </strong>Reference LVs were designed from the scan files of two identical maxillary central incisor typodonts prepared for 0.3 mm and 0.5 mm LVs. LVs were manufactured additively with resins of different compositions, either using a tilting stereolithography (Irix Max [AM-IX] and Irix Plus [AM-IP]) or a digital light processing printer (VarseoSmile Crown Plus [AM-VS] and Tera Harz TC- 80DP [AM-GR]), and subtractively (Tetric CAD [SM-TC]) (n=10). All LVs were digitized to evaluate their fabrication trueness and fit. The margin quality was assessed through visual examination. The trueness and fit data were analyzed with two-way analysis of variance and Tukey tests, while the chi-squared test was used to evaluate the margin quality (α = 0.05).</p><p><strong>Results: </strong>The interaction between the main factors and the manufacturing trinomial affected the fabrication trueness and fit, while restoration thickness affected the fit of tested LVs (P ≤ 0.001). AM-IP mostly had the lowest deviations, followed by AM-IX, and mostly had the lowest gaps (P ≤ 0.037). Thinner LVs had lower gaps (P < 0.001). Tested LVs mostly had slightly rough margins with small defects.</p><p><strong>Conclusions: </strong>LVs fabricated with the tilting stereolithography printer mostly had higher trueness. Using AM-IP or fabricating 0.3 mm LVs improved the fit. Nevertheless, all tested LVs had clinically acceptable fit.</p><p><strong>Clinical significance: </strong>Ultrathin laminate veneers fabricated with the manufacturing trinomial involving tested tilting stereolithography printer and resins may require less clinical adjustments. In addition, one of the resins (AM-IP) within this manufacturing trinomial or fabricating 0.3 mm laminate veneers may improve the fit.</p>","PeriodicalId":15585,"journal":{"name":"Journal of dentistry","volume":" ","pages":"105606"},"PeriodicalIF":4.8,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143122841","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Tooth loss explains income inequalities in dementia","authors":"Satomi Shimada,&nbsp;Yusuke Matsuyama,&nbsp;Jun Aida","doi":"10.1016/j.jdent.2024.105518","DOIUrl":"10.1016/j.jdent.2024.105518","url":null,"abstract":"<div><h3>Objectives</h3><div>Socioeconomic inequalities in oral health and dementia exist worldwide. This study investigated the mediating effects of tooth loss on the association between income and dementia.</div></div><div><h3>Methods</h3><div>This study used data from the Japan Gerontological Evaluation Study, which targeted people aged ≥65 years. The explanatory variable was equivalent income in 2010. The outcome variable was dementia incidence between 2010 and 2022. Cox proportional hazard regression was used to examine the association between income and dementia incidence, adjusting for confounders. We performed causal mediation analyses to evaluate the extent to which the number of natural teeth mediates the association.</div></div><div><h3>Results</h3><div>Among the 21,306 participants, the mean age was 73.4 years, and 53.5 % were females. The cumulative incidence of dementia was 19.7 % for people with higher incomes and 24.0 % for those with lower incomes. People with lower incomes had fewer teeth (the prevalence of having ≥20 teeth: 42.2 % in higher incomes and 31.1 % in lower incomes). Lower income was associated with dementia after adjusting for confounders (Hazard ratio (HR) [95 % confidence interval (CI)]: 1.18 [1.10; 1.26]), which was partially attenuated by controlling for the number of teeth (HR [95 % CI]: 1.17 [1.09; 1.25]). Causal mediation analysis demonstrated that the proportion mediated by the number of teeth was 6.6 %.</div></div><div><h3>Conclusions</h3><div>Our study found that tooth loss partially mediated the association between income and dementia. Preventing tooth loss appears to reduce inequalities in dementia among older people.</div></div><div><h3>Clinical significance</h3><div>Tooth loss has mediating effects on the association between income and dementia. Strategies for maintaining natural teeth seem effective in reducing the socioeconomic inequalities of dementia.</div></div>","PeriodicalId":15585,"journal":{"name":"Journal of dentistry","volume":"153 ","pages":"Article 105518"},"PeriodicalIF":4.8,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142800952","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Indexing status of orthodontic research published in presumed predatory journals: A bibliometric study","authors":"Michael P Maroulakos ,&nbsp;Dalya Al-Moghrabi ,&nbsp;Isabel Fleischmann ,&nbsp;Nikolaos Pandis ,&nbsp;Padhraig S Fleming","doi":"10.1016/j.jdent.2024.105464","DOIUrl":"10.1016/j.jdent.2024.105464","url":null,"abstract":"<div><h3>Objectives</h3><div>To examine the indexing status of presumed predatory orthodontic publications within established scientific databases.</div></div><div><h3>Methods</h3><div>Six electronic databases were searched to identify English language orthodontic articles published in 2022. Equal numbers of articles from legitimate (<em>n</em> = 159) and suspect or predatory journals (<em>n</em> = 159) were considered. Data regarding journal, article and author characteristics were obtained. The indexing status of the publications in PubMed, Ovid, Embase, Web of Science, Scopus and EBSCOhost was evaluated. The total number of databases that the article was indexed in, level of evidence, origin of first author and research funding were recorded. Univariable ordinal regression analyses were performed to explore potential association between article legitimacy and indexing status.</div></div><div><h3>Results</h3><div>The majority of studies in predatory journals were found in non-specialized journals (79.6 %). Scopus was the most porous database, indexing over half of predatory and suspect articles (56 %). In Web of Science (Core collection), the distribution of articles across different indexing categories varied (SCIE; 16.4 %, ESCI; 30.2 %). In contrast, only 8.2 % of these articles appeared in Medline. Articles in legitimate journals tended to have higher level of evidence and were indexed in more databases in comparison to predatory/suspect publications (OR = 1.5; 95 % CI: 1.37–1.64; <em>p</em> &lt; 0.01). The origin of the first author was a significant predictor for journal legitimacy (<em>p</em> &lt; 0.001).</div></div><div><h3>Conclusion</h3><div>A high proportion of orthodontic publications appear in presumed predatory and suspect journals which are in turn often indexed in trustworthy databases. Medline was the least susceptible to predatory publications, while Scopus and ESCI were more prone.</div></div><div><h3>Clinical significance</h3><div>Predatory and suspect journals are increasingly prevalent with increasing prominence being afforded by their penetration through recognized databases.</div></div>","PeriodicalId":15585,"journal":{"name":"Journal of dentistry","volume":"153 ","pages":"Article 105464"},"PeriodicalIF":4.8,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142639014","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dental resin for periodontal and tooth root regeneration via metformin to enhance osteogenic and cementogenic differentiation of human periodontal ligament stem cells","authors":"Kan Yu ,&nbsp;Minjia Zhu ,&nbsp;Zixiang Dai ,&nbsp;Qinrou Zhang ,&nbsp;Le Xiao ,&nbsp;Xinyi Li ,&nbsp;Jialiang Dai ,&nbsp;Zihan Jia ,&nbsp;Jingyi Li ,&nbsp;Yuxing Bai ,&nbsp;Ke Zhang","doi":"10.1016/j.jdent.2024.105507","DOIUrl":"10.1016/j.jdent.2024.105507","url":null,"abstract":"<div><h3>Objectives</h3><div>This study developed a novel dental resin incorporating metformin to repair root caries and periodontitis defects. The objectives were to: (1) Develop a novel dental resin with metformin release to fulfill the clinical requirements for mechanical properties; and (2) investigate the metformin release pattern and the effects on osteogenic and cementogenic differentiation of human periodontal ligament stem cells (hPDLSCs).</div></div><div><h3>Methods</h3><div>Resin specimens with different concentrations of metformin were fabricated. Metformin release was measured using high-performance liquid chromatography. Cellular growth and proliferation on resin were assessed. Alizarin red S staining and an alkaline phosphatase (ALP) activity were determined. Quantitative real-time reverse transcription PCR was employed to determine osteogenic and cementogenic differentiation.</div></div><div><h3>Results</h3><div>The resin with 7.5 % metformin had mechanical properties comparable to those of a commercial control, thus satisfying the clinical requirements (mean ± SD; <em>n =</em> 10). hPDLSCs showed robust growth and proliferation on resin. At 14 days, the number of hPDLSCs increased by four-fold (<em>p &gt;</em> 0.1). ALP activity in the metformin group was 1.8 times higher than that of control (<em>p &lt;</em> 0.05). At 21 days, the metformin group showed a significant increase in mineral synthesis. Metformin group had cementogenic and osteogenic differentiation values that were 2.5 and 2.3 times higher, respectively, than control without metformin (<em>p &lt;</em> 0.05).</div></div><div><h3>Significance</h3><div>A metformin-resin was formulated that greatly promoted both cementogenic and osteogenic differentiation for the first time. This resin was mechanically strong and supported hPDLSC adhesion, growth and proliferation. This resin substantially enhanced hPDLSC osteogenic and cementogenic differentiation, yielding mineral synthesis of hPDLSCs more than 2-fold that of control without metformin. This new metformin-resin shows promise for the restoration of tooth root caries and the regeneration of periodontal tissues including alveolar bone and cementum.</div></div>","PeriodicalId":15585,"journal":{"name":"Journal of dentistry","volume":"153 ","pages":"Article 105507"},"PeriodicalIF":4.8,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142791924","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum to “A feasibility study to recruit, retain and treat periodontitis in volunteers with mild dementia, whilst monitoring their cognition” [Journal of Dentistry, 150 (2024) 105355]","authors":"Tanya L Cerajewska ,&nbsp;Maria Davies ,&nbsp;Shelley J Allen-Birt ,&nbsp;Marta Swirski ,&nbsp;Elizabeth J Coulthard ,&nbsp;Nicola X West","doi":"10.1016/j.jdent.2024.105537","DOIUrl":"10.1016/j.jdent.2024.105537","url":null,"abstract":"","PeriodicalId":15585,"journal":{"name":"Journal of dentistry","volume":"153 ","pages":"Article 105537"},"PeriodicalIF":4.8,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142894698","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}