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Prevalence of edentulousness, prosthetic need and panoramic radiographic findings of totally and partially edentulous patients in a sample of Turkish population - 在土耳其人口样本中,全牙和部分无牙患者的无牙患病率,义肢需求和全景x线检查结果
Pub Date : 2014-01-01 DOI: 10.5455/jeim.180614.or.106
H. Avsever, K. Gündüz, K. Orhan, G. Canitezer, B. Piskin, M. Akyol
Objective: The aim of this study was to investigate the panoramic radiographic findings of totally and partially edentulous patients and to reveal the significant role of radiographic evaluations before prosthodontic treatment in a sample of Turkish population. Methods: A total of 845 patients referred to our hospital for removable dentures were selected. All of the patients were totally or partially edentulous. The patients had clinical and radiographic examinations. All of the radiographs were evaluated for significant radiographic findings as follows: retained root fragments, embedded teeth, radio-lucencies, radio-opacities, maxillary sinus position and the location of the mental foramen. The obtained data were analyzed using descriptive statistics. Results: Positive radiographic findings were found in 40.47% of the patients who referred for removable prosthesis. Totally 84 retained roots were found in 74 patients; 64 (%76.2) of them have only one, and 10 (%11.9) have two retained roots. A total of 49 impacted teeth were found in 42 patients. According to our evaluation, 4.1% of patients (n = 35; female 17, male 18) have one; 0.8% of patients (n = 7; female 3, male 4) have two embedded teeth. Migrated sinus floor to the alveolar ridge was the most observed finding (37.5%), followed by resorption of alveolar ridge (4.5% of the patients, n = 38) in mental region. Moreover, 16 soft tissue calcifications, 12 osteosclerosis and 11 foreign bodies were found. Conclusions: Radiographic examination is crucial for pre-prosthetic evaluation on partially or totally edentulous patients that should considered as the first step to avoid the repetition of prosthetic rehabilitation, time waste, prestige loss and high treatment costs.
目的:本研究的目的是调查全无牙和部分无牙患者的全景x线片表现,并揭示在土耳其人群样本中修复治疗前x线片评估的重要作用。方法:选取845例来我院行活动义齿治疗的患者。所有患者全部或部分无牙。患者均行临床及影像学检查。所有的x线片都评估了以下重要的x线表现:保留的牙根碎片,嵌埋的牙齿,x线透光,x线混浊,上颌窦位置和颏孔位置。所得数据采用描述性统计进行分析。结果:40.47%的患者行可移动假体手术,x线片阳性。74例患者共发现84根保留;其中64个(%76.2)只有一个保留根,10个(%11.9)有两个保留根。42例患者共发现49颗阻生牙。根据我们的评估,4.1%的患者(n = 35;女17名,男18名)各1名;0.8%的患者(n = 7;雌性有两颗嵌齿,雄性有两颗嵌齿。窦底向牙槽嵴移位最多(37.5%),其次是精神区牙槽嵴吸收(4.5%,n = 38)。软组织钙化16例,骨硬化12例,异物11例。结论:x线检查对部分或全部无牙患者义肢前评估至关重要,应作为第一步考虑,以避免义肢康复的重复、时间浪费、声誉损失和高昂的治疗费用。
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引用次数: 1
Universal ethics in scientific publishing 科学出版中的普遍伦理
Pub Date : 2014-01-01 DOI: 10.5455/JEIM.060114.ED.018
S. Oter, George Ellington
In October 2013, John Bohannon, contributing correspondent of Science Magazine, published an intriguing work regarding the peer-review process of scientific open access journals, which attracted much attention around the globe. In brief, with the help of a professional team mainly based in Harvard University, he concocted analogous fake articles reporting anticancer effects of a chemical extracted from a lichen species. The articles contain major flaws in the study design and methodology, along with glaring mistakes in the presentation of results, and they end with irrelevant conclusions that should have led to their rejection after a quick editorial check. And yet, more than half of the 304 open access journals...
2013年10月,《科学》杂志特约记者约翰·博汉农发表了一篇关于科学开放获取期刊同行评议过程的有趣文章,引起了全球的广泛关注。简而言之,在主要来自哈佛大学的专业团队的帮助下,他炮制了类似的假文章,报道从地衣物种中提取的一种化学物质具有抗癌作用。这些文章在研究设计和方法上存在重大缺陷,在结果的呈现上也存在明显的错误,最后得出了不相关的结论,在经过编辑的快速检查后,这些结论本应被拒绝。然而,304种开放获取期刊中有一半以上……
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引用次数: 0
Mucus secreting activity and nitric oxide concentrations of ethanol-injured pylorus and duodenum of rats pretreated with Moringa oleifera - 辣木预处理乙醇损伤大鼠幽门、十二指肠粘液分泌活性及一氧化氮浓度
Pub Date : 2014-01-01 DOI: 10.5455/JEIM.260214.OR.097
O. K. Olaibi, O. Ijomone, I. Olawuni, S. O. Adewole, S. O. Akinsomisoye
Objective: The mechanism of ethanol-induced gastrointestinal mucosal lesions is known to include direct damage to mucus synthesis. The present study histochemically evaluated the activity of mucus secreting cells and determined the concentration of nitric oxide (NO) in ethanol injured pylorus and duodenum of rats pretreated with ethanol extract of Moringa oleifera (MO) leaves. Methods: Male adult rats were randomly assigned into five groups: group A served as control; group B received single dose of 5 ml/kg ethanol orally; group C received 200 mg/kg MO only orally for five days; group D and E received MO at 200 mg/kg and cimetidine at 100 mg/kg orally for five days, respectively, and then ethanol was administered at 5 ml/kg orally on the 6th day to these groups. Results: Ethanol significantly reduced NO concentration in pylorus, and this was attenuated with MO pretreatment. Pretreatment with both MO and cimetidine significantly attenuated the hemorrhagic injuries induced by ethanol. Pretreatment with MO increased activity of mucus secreting cells compared to ethanol only group. Conclusion: The present study demonstrated that the antiulcer activity of Moringa oleifera may be attributed to preservation of mucus secreting cells and maintenance of endogenous NO concentrations in ethanol injured gastroduodenal tissues.
目的:乙醇致胃肠道粘膜病变的机制包括直接损害粘液合成。本研究采用组织化学方法评价了辣木叶乙醇提取物预处理大鼠幽门和十二指肠后粘液分泌细胞的活性,并测定了一氧化氮(NO)浓度。方法:雄性成年大鼠随机分为5组:A组为对照组;B组给予单次剂量乙醇5 ml/kg口服;C组只口服200 mg/kg MO,连续5 d;D组和E组分别给予MO 200 mg/kg和西咪替丁100 mg/kg口服5 D,然后在第6天口服乙醇5 ml/kg。结果:乙醇能显著降低幽门组织NO浓度,而MO预处理能减弱该作用。MO和西咪替丁预处理均能显著减轻乙醇所致的出血性损伤。与纯乙醇组相比,MO预处理可提高粘液分泌细胞的活性。结论:辣木的抗溃疡作用可能与保护粘液分泌细胞和维持乙醇损伤胃十二指肠组织内源性NO浓度有关。
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引用次数: 5
Embryological basis of the virgin birth of Jesus 耶稣童贞女所生的胚胎学基础
Pub Date : 2014-01-01 DOI: 10.5455/JEIM.060113.HP.011
M. Irmak
Virgin Mary gave birth to Jesus without a father. A scenario is presented here for this miraculous event. She is a chimera of 46,XX/46,XY type resulting from the fusion of two embryos of different sex types and both ovary and testis develop in Her body. It is well known that in chimera XX cells tend to gather on the left side while XY cells on the right; therefore, an ovary develops at the left side with an oviduct and a testis develops at the right side of the abdominal cavity with no duct. Both gonads are functional and produce oocyte and spermatozoa respectively after puberty. At the time of ovulation, estrogens leads to a negative pressure in the left oviduct and this vacuum effect helps oocyte and sperms to be picked-up into the tube, taking both types of gametes to the fertilization site in the left oviduct. Because of the higher temperature of the oocyte at the left ovary, fertilization occurs with a Y-bearing sperm to give rise to a XY male embryo which becomes miraculously Jesus.
圣母玛利亚没有父亲就生下了耶稣。这里为这一奇迹般的事件呈现了一个场景。她是46,xx / 46,xy型嵌合体,由两个不同性别类型的胚胎融合而成,卵巢和睾丸都在她体内发育。众所周知,在嵌合体中,XX细胞倾向于聚集在左侧,而XY细胞倾向于聚集在右侧;因此,卵巢在左侧发育,有输卵管,睾丸在右侧发育,没有输卵管。青春期后,两个性腺功能正常,分别产生卵母细胞和精子。在排卵时,雌激素导致左侧输卵管的负压,这种真空效应有助于卵母细胞和精子被吸入输卵管,将两种类型的配子带到左侧输卵管的受精点。由于左侧卵巢的卵母细胞温度较高,携带y染色体的精子受精,产生一个XY染色体的男性胚胎,奇迹般地变成了耶稣。
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引用次数: 6
An option for painful diabetic neuropathy with simultaneous 'antioxidative' and 'anesthetic' properties: topical Citrullus colocynthis 同时具有“抗氧化”和“麻醉”特性的疼痛性糖尿病神经病变的一种选择:外用香瓜多糖
Pub Date : 2014-01-01 DOI: 10.5455/JEIM.031113.HP.009
M. Heydari, M. Shams, K. Homayouni, A. Borhani-Haghighi, A. Salehi, M. H. Hashempur
Diabetic neuropathy is probably the most common complication of diabetes mellitus. Secondary preventive measures for diabetic neuropathy with delaying, stopping or even reversing progressive course of neuropathy, pain control and prevention of ulceration can play important role in diabetic patients care. Oxidative stress plays an important role in pathogenesis of diabetic neuropathy. Treatments for diabetic neuropathy have been mainly focused on two purposes, pain control and repair of nerve injury. Therapeutic options for nerve injuries may not improve or even exacerbate painful symptoms. On the other hand most of treatments for pain control have little or no effect on nerve function. As a result of mentioned discrepancy between ‘nerve protection’ and ‘pain control’ in the treatment of painful diabetic neuropathy, it is hypothesized that Citrullus colocynthis as a therapeutic agent with simultaneous antioxidative and anesthetic effects can play an important role in treatment of painful diabetic neuropathy. Previous in vitro and animal studies of C.colocynthis demonstrated its ‘antioxidative’, ‘anesthetic’ and ‘antiulcerogenic’ effects. A randomized controlled double-blind clinical trial is needed to evaluate this hypothesis. © 2014 GESDAV
糖尿病性神经病变可能是糖尿病最常见的并发症。糖尿病神经病变的二级预防措施,延缓、停止甚至逆转神经病变的进展过程,控制疼痛和预防溃疡,在糖尿病患者的护理中发挥重要作用。氧化应激在糖尿病神经病变的发病机制中起重要作用。糖尿病神经病变的治疗主要集中在疼痛控制和神经损伤修复两个方面。神经损伤的治疗方案可能不会改善甚至加重疼痛症状。另一方面,大多数控制疼痛的治疗对神经功能的影响很小或没有影响。鉴于上述“神经保护”与“疼痛控制”在疼痛性糖尿病神经病变治疗中的差异,我们假设瓜蒌多糖作为一种同时具有抗氧化和麻醉作用的治疗剂可能在疼痛性糖尿病神经病变的治疗中发挥重要作用。先前的体外和动物研究表明,colocynthis具有“抗氧化”、“麻醉”和“抗溃疡”作用。需要一项随机对照双盲临床试验来评估这一假设。©2014 gesdav
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引用次数: 9
Evolution or adaptation? What do heritable adaptive changes imply? 进化还是适应?可遗传的适应性变化意味着什么?
Pub Date : 2014-01-01 DOI: 10.5455/JEIM.021113.HP.008
M. Irmak
Received September 19, 2013 Accepted November 2, 2013 Published Online December 16, 2013 DOI 10.5455/jeim.021113.hp.008 Corresponding Author M.Kemal Irmak Gulhane Askeri Tip Akademisi Yuksek Bilim Konseyi 06010 Etlik, Ankara, Turkey. mkirmak@gata.edu.tr
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引用次数: 0
Mineralizing process and morphological structure of the femoral bone in rats under influence of aminophosphonates 氨基膦酸盐对大鼠股骨矿化过程和形态结构的影响
Pub Date : 2014-01-01 DOI: 10.5455/JEIM.260214.BR.019
S. Mostovoy, V. F. Shul’gin, E. Maksimova, I. Nauhatsky, Elena T. Melucova, Kristina A. Plehanova
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引用次数: 5
Effectiveness of Cyperus scariosus and Boswellia serrata on quality of life in women with stress urinary incontinence assessed with ICIQ-SF - 用ICIQ-SF -评价scarius和Boswellia serrata对女性压力性尿失禁患者生活质量的影响
Pub Date : 2014-01-01 DOI: 10.5455/JEIM.240614.OR.107
A. Padmaja, A. Sultana, Khaleequr Rahman, Sumana Nagapattinam
Objective: To investigate and compare the efficacy of oleo-gum-resin of root of Cyperus scariosus and Boswellia serrata with placebo in improving health related quality of life (HRQOL) in women with stress urinary incontinence (SUI). Methods: A parallel, randomized placebo-controlled, single-blind, pre- and post-test trial was conducted in the National Institute of Unani Medicine Hospital. The patients (n = 60) were randomly allocated to either test (n = 30) or control group (n = 30). In the test and placebo group, equal quantity of C.scariosus and B.serrata (4 g powder in two divided doses) plus pelvic floor muscle training (PFMT) and placebo plus PFMT, respectively, was given for 8 weeks. The outcome was to assess HRQOL by International Consultation on Incontinence Questionnaire-Short Form (ICIQ-SF). Mann-Whitney, Wilcoxon Matched paired, Chi-square or Fisher Exact tests were used to analyze the results. Results: The mean ICIQ-SF score in the test and control group at baseline was 10.2 ± 0.96 and 10.13 ± 0.89 respectively. At post-intervention, statistically significant improvement was recorded in the ICIQ-SF scores between groups. In addition, within the group comparison was statistically significant in both groups at each follow up. The percentage improvement from baseline at 12 weeks was 70% and 53% in the test and control groups, respectively. No adverse effects were noted. Conclusion: The test group yielded a more positive effect with regards to improvement in HRQOL than control group in women with stress urinary incontinence. Hence, test drugs plus PFMT appear to be a better alternative than PFMT alone.
目的:探讨并比较香柏根油胶树脂与安慰剂对女性压力性尿失禁(SUI)患者健康相关生活质量(HRQOL)的改善效果。方法:采用平行、随机、安慰剂对照、单盲、前后试验的方法。患者(n = 60)随机分为试验组(n = 30)和对照组(n = 30)。在试验组和安慰剂组中,等量的scariosus和b.s serrata (4 g粉末,分两次剂量)加盆底肌肉训练(PFMT)和安慰剂加PFMT,分别给予8周。结果是通过国际失禁咨询问卷-短表(ICIQ-SF)评估HRQOL。使用Mann-Whitney、Wilcoxon配对、卡方检验或Fisher精确检验来分析结果。结果:试验组和对照组基线时ICIQ-SF评分平均值分别为10.2±0.96和10.13±0.89。干预后,组间ICIQ-SF评分有统计学显著改善。此外,两组每次随访的组内比较均有统计学意义。12周时,试验组和对照组较基线的改善百分比分别为70%和53%。没有发现不良反应。结论:试验组对压力性尿失禁患者HRQOL的改善效果优于对照组。因此,试验药物加PFMT似乎是比单独PFMT更好的选择。
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引用次数: 0
Medical aspects of ablution and prayer 医学方面的洗礼和祈祷
Pub Date : 2014-01-01 DOI: 10.5455/JEIM.291213.HP.010
M. Irmak
Brain is protected from thermal damage by a so-called radiator system: the brain cooling system. As the brain gets hotter, the veins of this radiator system bring in cool blood from the evaporating surfaces of skin and craniofacial cavities. The craniofacial regions important in brain cooling system are very similar to the regions washed or wetted with ablution. So washing the face, oral and nasal cavities, and wetting scalp, ears and nape 4-5 times a day help the brain to remain cool throughout the day. This obviously means that with ablution cooler the head, healthier the brain. However, when a person is erect, the basal surface of the brain is in close contact with the cranial bones and therefore cerebrospinal fluid (CSF) could not cool the basal parts of the brain in erect position. Of course the relations of CSF to the skull and the brain are reversed when a person stoops (such as bowing and prostrating) allowing the CSF to intervene between the brain and the skull. Therefore stooping (as Muslims do about 120 times a day with prayer) would be beneficial for cooling the brain entirely by providing the CSF to wash-up the basal parts of brain. As for the other benefits of prayer, grounding is another aspect which provides a basis that restores and maintains natural electrical contact between the human body and the earth.
大脑通过所谓的散热系统——大脑冷却系统——来保护大脑免受热损伤。当大脑变热时,这个散热系统的静脉从皮肤和颅面腔的蒸发表面带来凉爽的血液。在大脑冷却系统中重要的颅面区域与用沐浴液冲洗或润湿的区域非常相似。因此,每天洗脸、口腔和鼻腔、润湿头皮、耳朵和颈部4-5次,有助于大脑全天保持凉爽。这显然意味着,洗澡可以使头部更凉爽,大脑更健康。然而,当一个人直立时,大脑的基底表面与颅骨密切接触,因此脑脊液(CSF)不能冷却直立位置的大脑基底部分。当然,当一个人弯腰(比如鞠躬和俯伏)时,脑脊液与头骨和大脑的关系就会逆转,从而使脑脊液在大脑和头骨之间进行干预。因此弯腰(就像穆斯林每天祈祷时做的120次)将有助于通过提供脑脊液来清洗大脑的基础部分,从而彻底冷却大脑。至于祈祷的其他好处,接地是另一个方面,它提供了恢复和保持人体与地球之间自然电接触的基础。
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引用次数: 6
Phytochemical constituents and antidiabetic potential of Ipomoea carnea Jacq leaves extracts 山茱萸叶提取物的植物化学成分及抗糖尿病作用
Pub Date : 2014-01-01 DOI: 10.5455/JEIM.210214.OR.096
T. Khan, R. Raina, P. Verma, M. Sultana, M. K. Jyoti
Objective: Plants are a kind of library of diverse chemical scaffold and much of them remain to be explored. The present study aimed to evaluate the phytochemical ingredients of Ipomoea carnea Jacq leaves extracts and its antidiabetic potential in streptozotocin (STZ)-induced diabetes in Wistar rats. Methods: Diabetes was induced by single intra-peritoneal injection of STZ at a dose of 60 mg/kg body weigt (BW). The onset of diabetes happened within 5 days post-injection. Antidiabetic potential of different extracts were evaluated at the dose rate of 500 mg/kg BW through oral gavage continuously for 3 weeks in rats. Phytochemical ingredients like total phenolic, flavonoid and tannin contents were determined in hot, cold aqueous and alcoholic extracts of I.carnea leaves. Results: Alcoholic extract presented marked higher phenolic, flavonoid and tannin contents as compared to aqueous extracts. Repeated oral administration of extracts significantly decreases the blood glucose, plasma triglyceride, total cholesterol, low density lipoprotein level and increased high density lipoprotein level in rats as compared to the diabetic control group rats. Further, alcoholic extract showed better hypoglycemic and hypolipidemic effects than the aqueous extracts; this may be due to the presence of significantly higher levels of phenols and flavonoids. Conclusion: Observations of the study suggested that I.carnea leaf extracts have antidiabetic potential in rats. The antidiabetic potential of extracts may be due to the high content of phenols and flavonoids. © 2014 GESDAV
目的:植物是一个丰富多样的化学支架库,其中有许多还有待探索。本研究旨在评价香豆叶提取物的植物化学成分及其对链脲佐菌素(STZ)诱导的Wistar大鼠糖尿病的抑制作用。方法:单次腹腔注射STZ,剂量为60 mg/kg体重(BW)。糖尿病发生在注射后5天内。以500 mg/kg BW剂量率连续灌胃3周,评价不同提取物的降糖作用。采用热、冷、水、醇三种提取液,测定了其总酚、类黄酮、单宁等化学成分的含量。结果:醇提物的酚类、类黄酮和单宁含量明显高于水提物。与糖尿病对照组大鼠相比,反复口服提取物可显著降低大鼠血糖、血浆甘油三酯、总胆固醇、低密度脂蛋白水平,并使高密度脂蛋白水平升高。此外,酒精提取物比水提取物具有更好的降糖和降血脂作用;这可能是由于存在明显较高水平的酚类和类黄酮。结论:本研究表明,金银花叶提取物对大鼠具有抗糖尿病作用。提取物的抗糖尿病潜力可能是由于高含量的酚类和类黄酮。©2014 gesdav
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引用次数: 6
期刊
Journal of Experimental and Integrative Medicine
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