Pub Date : 2016-01-01DOI: 10.5455/JEIM.160716.OR.154
O. B. Eze, O. Nwodo, V. N. Ogugua, P. Joshua
Objective: To evaluate the ameliorating effect of ethanol extract of Sida acuta Burm F. leaves on inflammatory disorder and some of its anti-oxidants activity. Methods: It was conducted using 25 adult wistar albino rats. They were divided into five groups of five rats each. Group1 administered 5 ml/kg of normal saline (control group). Group 2, 3 and 4 administered 100, 200 and 400 mg/kg of ethanol extract of Sida acuta leaves while group 5 were administered 200 mg/kg of phenylbutazone (vehicle control). Paw oedema was induced using 0.1 ml of undiluted fresh albumin egg (philogistic agent) into the subplantar surface of the right hind paw of the rats. Superoxide dismutase activity, Catalase activity, Vitamine E concentration and Malondialdehyde level were assessed. Results: The extract at doses of 100, 200 and 400 mg/kg and phenylbutazone 200 mg/kg were administered intraperitoneally to respective groups of the rats. Control group received 5 ml/kg of normal saline. Doses of the extract 100, 200 and 400 mg/kg significantly (p < 0.05) reduced the fresh egg albumin induced rat paw oedema compared to control administered 5 ml/kg normal saline. The oedema reductions were more than that obtained for phenylbutazone; the standard anti-inflammatory agent. Non-significant (p > 0.05) reductions were observed in the activity of superoxide dismutase in the sera of the test groups administered 100, 200 and 400 mg/kg extract and 200 mg/kg phenylbutazone respectively compared to the control. Significant (p < 0.05) increase was observed in the concentration of vitamin E and catalase activity in rats administered 400 mg/kg of the extract and 200 mg/kg phenylbutazone in groups 4 and 5 respectively compared to the control. Conclusion: It was observed that the ethanol extract of Sida acuta leaves posses anti-inflammatory and anti-oxidants properties which reduced paw oedema induced- inflammation to some extent.
{"title":"Effect of ethanol extract of sida acuta burm f. leaves on egg albumin-induced inflammation. -","authors":"O. B. Eze, O. Nwodo, V. N. Ogugua, P. Joshua","doi":"10.5455/JEIM.160716.OR.154","DOIUrl":"https://doi.org/10.5455/JEIM.160716.OR.154","url":null,"abstract":"Objective: To evaluate the ameliorating effect of ethanol extract of Sida acuta Burm F. leaves on inflammatory disorder and some of its anti-oxidants activity. Methods: It was conducted using 25 adult wistar albino rats. They were divided into five groups of five rats each. Group1 administered 5 ml/kg of normal saline (control group). Group 2, 3 and 4 administered 100, 200 and 400 mg/kg of ethanol extract of Sida acuta leaves while group 5 were administered 200 mg/kg of phenylbutazone (vehicle control). Paw oedema was induced using 0.1 ml of undiluted fresh albumin egg (philogistic agent) into the subplantar surface of the right hind paw of the rats. Superoxide dismutase activity, Catalase activity, Vitamine E concentration and Malondialdehyde level were assessed. Results: The extract at doses of 100, 200 and 400 mg/kg and phenylbutazone 200 mg/kg were administered intraperitoneally to respective groups of the rats. Control group received 5 ml/kg of normal saline. Doses of the extract 100, 200 and 400 mg/kg significantly (p < 0.05) reduced the fresh egg albumin induced rat paw oedema compared to control administered 5 ml/kg normal saline. The oedema reductions were more than that obtained for phenylbutazone; the standard anti-inflammatory agent. Non-significant (p > 0.05) reductions were observed in the activity of superoxide dismutase in the sera of the test groups administered 100, 200 and 400 mg/kg extract and 200 mg/kg phenylbutazone respectively compared to the control. Significant (p < 0.05) increase was observed in the concentration of vitamin E and catalase activity in rats administered 400 mg/kg of the extract and 200 mg/kg phenylbutazone in groups 4 and 5 respectively compared to the control. Conclusion: It was observed that the ethanol extract of Sida acuta leaves posses anti-inflammatory and anti-oxidants properties which reduced paw oedema induced- inflammation to some extent.","PeriodicalId":16091,"journal":{"name":"Journal of Experimental and Integrative Medicine","volume":"93 1","pages":"82-87"},"PeriodicalIF":0.0,"publicationDate":"2016-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77208250","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2016-01-01DOI: 10.5455/JEIM.120716.OR.155
S. Usman, O. Kalejaye, I. Isola, O. Oluwaniyi, A. K. Ojogbede, Ayooluwa Samuel Adu
Objectives: Couples space the number of years between each child they want to give birth to through the use of contraceptive methods. It is widely reported that people who do not use any birth control plan may lack access or face barriers, which may include partners’ non-acceptance, fear of side effects or risks. This study is therefore carried out to determine the child spacing and family planning strategies, obtain the values and norms that influence the knowledge and practice of family planning, among rural community women of reproductive ages in South-Western Nigeria with a view to making necessary recommendations that would help improve family planning practices. Methods: This cross sectional study was carried out in towns across the three senatorial districts of two South-Western states of Ondo & Ekiti in Nigeria. The target population was women of reproductive age group in these districts. A multi-stage sampling technique was used to select the respondent. All data were statistically analysed, using statistical package for the social sciences (SPSS) and statistical test of significance was performed with Chi-Square test. Results: A total of 1500 consenting respondents participated in the study with a mean age ± SD of 33.69 ± 11.14 years. The main reason given for choice of family planning was reliability, main source of information is through government-owned hospital health personnel, male condom is the most widely used current family planning method while heavy menstrual period is the commonly known side effect. Conclusion: Indications show that educational status, religious factor and economic status influence family planning and choices made, there is therefore need for more campaign and public enlightenment programs on modern family planning methods, importance, choices and benefits, crucially including the religious leaders, in order to fast track the information spread and further improve the use of modern contraceptive methods.
{"title":"Family planning practices among rural community women in Nigeria","authors":"S. Usman, O. Kalejaye, I. Isola, O. Oluwaniyi, A. K. Ojogbede, Ayooluwa Samuel Adu","doi":"10.5455/JEIM.120716.OR.155","DOIUrl":"https://doi.org/10.5455/JEIM.120716.OR.155","url":null,"abstract":"Objectives: Couples space the number of years between each child they want to give birth to through the use of contraceptive methods. It is widely reported that people who do not use any birth control plan may lack access or face barriers, which may include partners’ non-acceptance, fear of side effects or risks. This study is therefore carried out to determine the child spacing and family planning strategies, obtain the values and norms that influence the knowledge and practice of family planning, among rural community women of reproductive ages in South-Western Nigeria with a view to making necessary recommendations that would help improve family planning practices. Methods: This cross sectional study was carried out in towns across the three senatorial districts of two South-Western states of Ondo & Ekiti in Nigeria. The target population was women of reproductive age group in these districts. A multi-stage sampling technique was used to select the respondent. All data were statistically analysed, using statistical package for the social sciences (SPSS) and statistical test of significance was performed with Chi-Square test. Results: A total of 1500 consenting respondents participated in the study with a mean age ± SD of 33.69 ± 11.14 years. The main reason given for choice of family planning was reliability, main source of information is through government-owned hospital health personnel, male condom is the most widely used current family planning method while heavy menstrual period is the commonly known side effect. Conclusion: Indications show that educational status, religious factor and economic status influence family planning and choices made, there is therefore need for more campaign and public enlightenment programs on modern family planning methods, importance, choices and benefits, crucially including the religious leaders, in order to fast track the information spread and further improve the use of modern contraceptive methods.","PeriodicalId":16091,"journal":{"name":"Journal of Experimental and Integrative Medicine","volume":"95 1","pages":"88-92"},"PeriodicalIF":0.0,"publicationDate":"2016-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88967492","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2016-01-01DOI: 10.5455/jeim.310316.rw.014
Fabián Hernández, Sathees B. C. Chandra
Abstract Cannabis sativa has long been linked as a medicinal treatment to many conditions such as cancer, epilepsy, bone fracture healing, anti-inflammatory response, neuro-degenerative disorders such as multiple sclerosis (MS), and rheumatoid arthritis. This article discusses the underlying conditions that are significantly controlled or modulated by cannabis. The primary components that have been isolated from cannabis are the psychoactive cannabinoid Δ (9)-tetrahydrocannabinol (THC) and cannabidiol (CBD). Both cannabinoids bind directly to endocannabinoid receptors that are located abundantly in the nervous system and visceral organs. Cannabis has also been used as a treatment to manage pain for chemotherapy patients and induce hunger in HIV (Human Immunodeficiency Virus) positive patients. Cannabis has received vast amounts of attention because of its effect on treating epilepsy. Although the biochemical pathway for this is not yet known, the current evidence in favor of this treatment has opened the door for further research. Finally, the cannabis terpenoids that have been isolated from cannabis sativa are discussed as a future focal point for cannabis research. This review article sets to provide the medical community with a broad synopsis of recent research trials on Cannabis sativa that have indicated its medicinal benefits. The removal of the Public Health Service (PHS) Review, which has inhibited government funding and access to research samples, is an imperative step for obtaining further knowledge into the biochemical pathways and effects of medical cannabis.
{"title":"The current state and potential direction of cannabis research","authors":"Fabián Hernández, Sathees B. C. Chandra","doi":"10.5455/jeim.310316.rw.014","DOIUrl":"https://doi.org/10.5455/jeim.310316.rw.014","url":null,"abstract":"Abstract Cannabis sativa has long been linked as a medicinal treatment to many conditions such as cancer, epilepsy, bone fracture healing, anti-inflammatory response, neuro-degenerative disorders such as multiple sclerosis (MS), and rheumatoid arthritis. This article discusses the underlying conditions that are significantly controlled or modulated by cannabis. The primary components that have been isolated from cannabis are the psychoactive cannabinoid Δ (9)-tetrahydrocannabinol (THC) and cannabidiol (CBD). Both cannabinoids bind directly to endocannabinoid receptors that are located abundantly in the nervous system and visceral organs. Cannabis has also been used as a treatment to manage pain for chemotherapy patients and induce hunger in HIV (Human Immunodeficiency Virus) positive patients. Cannabis has received vast amounts of attention because of its effect on treating epilepsy. Although the biochemical pathway for this is not yet known, the current evidence in favor of this treatment has opened the door for further research. Finally, the cannabis terpenoids that have been isolated from cannabis sativa are discussed as a future focal point for cannabis research. This review article sets to provide the medical community with a broad synopsis of recent research trials on Cannabis sativa that have indicated its medicinal benefits. The removal of the Public Health Service (PHS) Review, which has inhibited government funding and access to research samples, is an imperative step for obtaining further knowledge into the biochemical pathways and effects of medical cannabis.","PeriodicalId":16091,"journal":{"name":"Journal of Experimental and Integrative Medicine","volume":"259 1-2 1","pages":"44-48"},"PeriodicalIF":0.0,"publicationDate":"2016-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78442718","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2016-01-01DOI: 10.5455/JEIM.140916.OR.160
O. Ayanniyi, A. O. Sanya, O. S. Ogunlade
ABSTRACT INTRODUCTION AND AIM: Back pain (BP) is a common complaint of women during pregnancy, and it constituted a burden to the affected individuals. The objective of this study was to determine the effects of McKenzie protocol (MP) in managing pregnancy-related BP among women. MATERIALS AND METHODS: Women with pregnancy-related BP were purposively recruited and randomly assigned to McKenzie protocol plus usual care (MPG) and Usual care only (UCG). The participants in the MPG were treated with MP in addition to the usual care. The women in the UCG received usual care only. Participants were treated within six weeks and then assessed. Pre and post-intervention pain intensity and disability level were assessed using Numerical pain rating scale and Modified Ronald Morris Disability Questionnaires. Data obtained were analyzed using descriptive and inferential statistics. RESULTS: There were no statistically significant differences in the independent t-test comparison of the pre-treatment pain intensity [LBP (p = 0 . 989), HBP (p = 0 .306), PGP (0 .296)] and functional disability scores [LBP (p = 0. 483); HBP (p = 0. 306), PGP(P = 0. 209)] between MPG and UCG respectively. At the end of the 6 weeks of intervention the independent t-test comparison of the post-treatment pain and disability scores of the participants in the MPG and UCG showed statistically significant difference in pain intensity score reduction [LBP (p = 0. 001), HBP (p = 0. 001), PGP (p = 0. 001)] and disability score reduction [LBP (p = 0. 001), HBP (p = 0. 001), PGP (p = 0. 001)] respectively. CONCLUSION: Addition of McKenzie protocol to usual care produced significant relief from back pain and disability of participants in the MPG at the end of six weeks intervention irrespective of back pain types. It is recommended that McKenzie protocol should be considered in the management of pregnancy- related back pain. Keywords: McKenzie protocol, usual care, pregnancy- related back pain.
{"title":"Effects of the McKenzie protocol on pregnancy- related back pain -","authors":"O. Ayanniyi, A. O. Sanya, O. S. Ogunlade","doi":"10.5455/JEIM.140916.OR.160","DOIUrl":"https://doi.org/10.5455/JEIM.140916.OR.160","url":null,"abstract":"ABSTRACT INTRODUCTION AND AIM: Back pain (BP) is a common complaint of women during pregnancy, and it constituted a burden to the affected individuals. The objective of this study was to determine the effects of McKenzie protocol (MP) in managing pregnancy-related BP among women. MATERIALS AND METHODS: Women with pregnancy-related BP were purposively recruited and randomly assigned to McKenzie protocol plus usual care (MPG) and Usual care only (UCG). The participants in the MPG were treated with MP in addition to the usual care. The women in the UCG received usual care only. Participants were treated within six weeks and then assessed. Pre and post-intervention pain intensity and disability level were assessed using Numerical pain rating scale and Modified Ronald Morris Disability Questionnaires. Data obtained were analyzed using descriptive and inferential statistics. RESULTS: There were no statistically significant differences in the independent t-test comparison of the pre-treatment pain intensity [LBP (p = 0 . 989), HBP (p = 0 .306), PGP (0 .296)] and functional disability scores [LBP (p = 0. 483); HBP (p = 0. 306), PGP(P = 0. 209)] between MPG and UCG respectively. At the end of the 6 weeks of intervention the independent t-test comparison of the post-treatment pain and disability scores of the participants in the MPG and UCG showed statistically significant difference in pain intensity score reduction [LBP (p = 0. 001), HBP (p = 0. 001), PGP (p = 0. 001)] and disability score reduction [LBP (p = 0. 001), HBP (p = 0. 001), PGP (p = 0. 001)] respectively. CONCLUSION: Addition of McKenzie protocol to usual care produced significant relief from back pain and disability of participants in the MPG at the end of six weeks intervention irrespective of back pain types. It is recommended that McKenzie protocol should be considered in the management of pregnancy- related back pain. Keywords: McKenzie protocol, usual care, pregnancy- related back pain.","PeriodicalId":16091,"journal":{"name":"Journal of Experimental and Integrative Medicine","volume":"112 1","pages":"118-124"},"PeriodicalIF":0.0,"publicationDate":"2016-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75863958","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2016-01-01DOI: 10.5455/JEIM.270616.RW.016
Shaifur Rahman, H. M. Jamil, Naznin Akhtar, R. Islam, M. Rana, S. Abdul-Awal, S. M. Asaduzzaman
Gene expression mechanism are controlled and coordinated by epigenetic regulators, including histone modification, CpG-island methylation and chromatin looping. Imbalance of these epigenetic marks (epimutation) can lead to many anomalies including cancer. In recent years, research has suggested that cancer growth and survive through the combined effect of genetic (gene mutation) and epigenetic (epimutation) changes that ultimately reprogram the cell to undergo uncontrolled. After discovering the reversibility of epigenetic alterations, new perspective of cancer mechanisms and therapies have been opened. And the lists of novel therapies that work by reversing epigenetic effects (inhibition/activation based) are being increasingly explored. DNA methyltransferases inhibitors, histone deacetylases inhibitors and miRNAs have shown promising result in clinical trials both alone and in combination with other anticancer drugs. However, in this article we discussed the current understanding of epigenetic mechanisms of cancer development, and we also highlighted recent successes of the reversion in cancer epigenetics drug discovery.
{"title":"Cancer epigenetics and epigenetical therapy","authors":"Shaifur Rahman, H. M. Jamil, Naznin Akhtar, R. Islam, M. Rana, S. Abdul-Awal, S. M. Asaduzzaman","doi":"10.5455/JEIM.270616.RW.016","DOIUrl":"https://doi.org/10.5455/JEIM.270616.RW.016","url":null,"abstract":"Gene expression mechanism are controlled and coordinated by epigenetic regulators, including histone modification, CpG-island methylation and chromatin looping. Imbalance of these epigenetic marks (epimutation) can lead to many anomalies including cancer. In recent years, research has suggested that cancer growth and survive through the combined effect of genetic (gene mutation) and epigenetic (epimutation) changes that ultimately reprogram the cell to undergo uncontrolled. After discovering the reversibility of epigenetic alterations, new perspective of cancer mechanisms and therapies have been opened. And the lists of novel therapies that work by reversing epigenetic effects (inhibition/activation based) are being increasingly explored. DNA methyltransferases inhibitors, histone deacetylases inhibitors and miRNAs have shown promising result in clinical trials both alone and in combination with other anticancer drugs. However, in this article we discussed the current understanding of epigenetic mechanisms of cancer development, and we also highlighted recent successes of the reversion in cancer epigenetics drug discovery.","PeriodicalId":16091,"journal":{"name":"Journal of Experimental and Integrative Medicine","volume":"54 1","pages":"143-150"},"PeriodicalIF":0.0,"publicationDate":"2016-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85224115","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2016-01-01DOI: 10.5455/JEIM.260116.OR.145
Y. Zidan, S. Bouderbala, M. Bouchenak
Objective: The aim of this study was to determine the effect of aqueous extract of Portulaca oleracea (Po) on lipid peroxidation as well as antioxidant enzymes activities in erythrocytes and tissues, in hypercholesterolemic rat. Methods: Male Wistar rats were fed on 1% cholesterol-enriched diet for 10 days, and were divided into two groups fed the same diet supplemented (Po-HC) or not (HC) with Po (0.5%) for four weeks. Results: Thiobarbituric acid reactive substances were significantly decreased in erythrocytes (-48%), adipose tissue (-37%) and heart (-37%) in Po-HC. Superoxide dismutase activity in erythrocytes, liver, muscle, heart and kidney was respectively, 1.2-, 1.3-, 1.2-, 1.5- and 1.2-fold higher in Po-HC group. Catalase activity in erythrocytes, liver and heart was respectively, 1.6-, 1.7- and 1.5-fold higher in Po-HC. Glutathione peroxidase activity was 1.2-fold increased in adipose tissue, whereas that of glutathione reductase was respectively 1.4 and 1.6-fold increased in adipose tissue and liver. Conclusion: Po is able to reduce oxidative stress in hypercholesterolemic rats by decreasing the lipid peroxidation and increasing the antioxidant enzymes activities of erythrocytes and tissues. The high content of phytoconstituents present in Po as flavonoids, alkaloids, omega-3 fatty acids, β-carotene, vitamin C, saponins and tannins are considered to be responsible for this effect.
{"title":"Portulaca oleracea aqueous extract reduces oxidative stress in erythrocytes and tissues, in rats fed enriched-cholesterol diet -","authors":"Y. Zidan, S. Bouderbala, M. Bouchenak","doi":"10.5455/JEIM.260116.OR.145","DOIUrl":"https://doi.org/10.5455/JEIM.260116.OR.145","url":null,"abstract":"Objective: The aim of this study was to determine the effect of aqueous extract of Portulaca oleracea (Po) on lipid peroxidation as well as antioxidant enzymes activities in erythrocytes and tissues, in hypercholesterolemic rat. Methods: Male Wistar rats were fed on 1% cholesterol-enriched diet for 10 days, and were divided into two groups fed the same diet supplemented (Po-HC) or not (HC) with Po (0.5%) for four weeks. Results: Thiobarbituric acid reactive substances were significantly decreased in erythrocytes (-48%), adipose tissue (-37%) and heart (-37%) in Po-HC. Superoxide dismutase activity in erythrocytes, liver, muscle, heart and kidney was respectively, 1.2-, 1.3-, 1.2-, 1.5- and 1.2-fold higher in Po-HC group. Catalase activity in erythrocytes, liver and heart was respectively, 1.6-, 1.7- and 1.5-fold higher in Po-HC. Glutathione peroxidase activity was 1.2-fold increased in adipose tissue, whereas that of glutathione reductase was respectively 1.4 and 1.6-fold increased in adipose tissue and liver. Conclusion: Po is able to reduce oxidative stress in hypercholesterolemic rats by decreasing the lipid peroxidation and increasing the antioxidant enzymes activities of erythrocytes and tissues. The high content of phytoconstituents present in Po as flavonoids, alkaloids, omega-3 fatty acids, β-carotene, vitamin C, saponins and tannins are considered to be responsible for this effect.","PeriodicalId":16091,"journal":{"name":"Journal of Experimental and Integrative Medicine","volume":"19 1","pages":"21-25"},"PeriodicalIF":0.0,"publicationDate":"2016-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80808822","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2016-01-01DOI: 10.5455/JEIM.091116.OR.164
A. Emokpae, H. Chima, M. Ahmed
{"title":"Seminal plasma caspase 3, cytochrome c and total antioxidant capacity in oligospermic males and association with sperm indices","authors":"A. Emokpae, H. Chima, M. Ahmed","doi":"10.5455/JEIM.091116.OR.164","DOIUrl":"https://doi.org/10.5455/JEIM.091116.OR.164","url":null,"abstract":"","PeriodicalId":16091,"journal":{"name":"Journal of Experimental and Integrative Medicine","volume":"4 1","pages":"168"},"PeriodicalIF":0.0,"publicationDate":"2016-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74325612","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2016-01-01DOI: 10.5455/jeim.020916.rw.017
M. Alhajj, Sathees B. C. Chandra
{"title":"Pemphigus Vulgaris: A Comprehensive Presentation of the Desmosomal Adhesion Disrupting and Oral Blister Causing Multifactorial Autoimmune Disease","authors":"M. Alhajj, Sathees B. C. Chandra","doi":"10.5455/jeim.020916.rw.017","DOIUrl":"https://doi.org/10.5455/jeim.020916.rw.017","url":null,"abstract":"","PeriodicalId":16091,"journal":{"name":"Journal of Experimental and Integrative Medicine","volume":"37 1","pages":"151"},"PeriodicalIF":0.0,"publicationDate":"2016-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78816260","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2016-01-01DOI: 10.5455/JEIM.180916.OR.161
Ogunnaike Olubunmi Philip, Olatunji Sunday Yinka, O. Oladele, Lawrence Ibeojo Glory, O. John
Objective: The general objective of this study was to evaluate the prevalence of dysmenorrhea and its effects on the quality of life among females of different age groups in a community. Methods: The study involves the random selection of 450 subjects with the use of a cross sectional survey among three (3) different age groups of 13-20 years, 21-30 years and 30-44 years with the aid of structure questionnaire to obtain data. Results: The result showed that more than half (54.7%) of age range 13-20 years female experienced severe dysmenorrhea, 36% experienced mildly severe pain while 9.3% had no severe pain. Among 21-30 years group, it was found that 53.7% experienced severe pain, 37% experienced mildly severe pain while 9.3% had no severe pain. Also among 31-44 age range, 57.3% experienced severe dysmenorrhea, 33.3% had mildly severe pain and 6.7% had no severe pain. 54% of age 13-20 years females adopted pharmacological method of pain relievers, 19.3% used non-pharmacological method while 24.7% combined both methods. Among 21-30 years age group, 26.7% used pharmacological treatment, 50% uses non pharmacological method and only 21.3% used both method. Poor work satisfaction was found to be 54.7% among 13-20 years female respondents, 70.0% among 21-30 years and 60.0% among 30-44 years respondents. Also, the study showed that 70% of the respondents experienced nauseous feelings, 65.3% experienced difficulties in breathing and 56.0% experienced decreased physical activities. Conclusion: The study concludes that socio-economic characteristics affect the prevalence and management of dysmenorrhea. Dysmenorrhea was shown to be more prevalent among females of younger ages and dysmenorrhea affects the quality of life among females of different age group. The effects manifested as: mood instabilities/emotional fluctuations (anger, aggression, joy, intense feeling of depression, irritability), reduction in academic performance (loss of concentration), and relationship with others are all affected by dysmenorrhea. This research shows that: lower BMI among ages 13-20 years and 21-30 years is directly associated with higher prevalence and severity of dysmenorrhea. This indicates that the younger females suffer a higher risk of having dysmenorrhea than the older females.
{"title":"A case study of the prevalence of dysmenorrhea and its effects among females of different age groups","authors":"Ogunnaike Olubunmi Philip, Olatunji Sunday Yinka, O. Oladele, Lawrence Ibeojo Glory, O. John","doi":"10.5455/JEIM.180916.OR.161","DOIUrl":"https://doi.org/10.5455/JEIM.180916.OR.161","url":null,"abstract":"Objective: The general objective of this study was to evaluate the prevalence of dysmenorrhea and its effects on the quality of life among females of different age groups in a community. Methods: The study involves the random selection of 450 subjects with the use of a cross sectional survey among three (3) different age groups of 13-20 years, 21-30 years and 30-44 years with the aid of structure questionnaire to obtain data. Results: The result showed that more than half (54.7%) of age range 13-20 years female experienced severe dysmenorrhea, 36% experienced mildly severe pain while 9.3% had no severe pain. Among 21-30 years group, it was found that 53.7% experienced severe pain, 37% experienced mildly severe pain while 9.3% had no severe pain. Also among 31-44 age range, 57.3% experienced severe dysmenorrhea, 33.3% had mildly severe pain and 6.7% had no severe pain. 54% of age 13-20 years females adopted pharmacological method of pain relievers, 19.3% used non-pharmacological method while 24.7% combined both methods. Among 21-30 years age group, 26.7% used pharmacological treatment, 50% uses non pharmacological method and only 21.3% used both method. Poor work satisfaction was found to be 54.7% among 13-20 years female respondents, 70.0% among 21-30 years and 60.0% among 30-44 years respondents. Also, the study showed that 70% of the respondents experienced nauseous feelings, 65.3% experienced difficulties in breathing and 56.0% experienced decreased physical activities. Conclusion: The study concludes that socio-economic characteristics affect the prevalence and management of dysmenorrhea. Dysmenorrhea was shown to be more prevalent among females of younger ages and dysmenorrhea affects the quality of life among females of different age group. The effects manifested as: mood instabilities/emotional fluctuations (anger, aggression, joy, intense feeling of depression, irritability), reduction in academic performance (loss of concentration), and relationship with others are all affected by dysmenorrhea. This research shows that: lower BMI among ages 13-20 years and 21-30 years is directly associated with higher prevalence and severity of dysmenorrhea. This indicates that the younger females suffer a higher risk of having dysmenorrhea than the older females.","PeriodicalId":16091,"journal":{"name":"Journal of Experimental and Integrative Medicine","volume":"382 1","pages":"125-133"},"PeriodicalIF":0.0,"publicationDate":"2016-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90214598","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2016-01-01DOI: 10.5455/JEIM.170316.OR.149
S. Akyol, S. Yuksel, M. A. Gulec, Þemsettin Þahin, K. Demircan, O. Akyol, H. Ozyurt
Objectives: Currently there is no effective chemotherapy for chondrosarcoma. Recent studies report that mesenchymal chondrosarcoma is relatively resistant to radiotherapy but sensitive to chemotherapy in some extend. It is unknown whether receptor tyrosine kinase is activated in chondrosarcoma. Potential new systemic treatment targets have been widely investigated. This study aimed to determine insulin-induced phosphorylation rate of signal proteins Akt, STAT-3, NF-κB and TLR4 by using Western Blot technique to find out a possible therapeutic target for human chondrosarcoma. Methods: Human chondrosarcoma cells (OUMS-27) were induced by 10 μmol/mL insulin for 60 min. The first group was untreated control group, while the others were insulin-induced groups for 10, 30, and 60 min by applying same amount of insulin. After the induction periods, cells were harvested and protein extractions were performed. Phosphorylated and unphosphorylated individual protein levels were detected. Results: Both pSTAT-3/STAT-3 and pNF-κB/NF-κB ratios were found to be remarkably increased (almost 3-fold) in 60 min group (almost 3-fold) compared those of controls. Conclusions: The mechanism of insulin action in OUMS-27 chondrosarcoma cell lines and other human chondrosarcomas has not yet been illuminated. According to our findings, STAT-3 and/or NF-κB could be intracellular molecules that transmit the message of insulin to inside of OUMS-27 cells. Especially the fact that the phosphorylated forms of these proteins increase 3 times after 60 minutes of the insulin induction supports our perspective. These signaling molecules might be considered as potential targets of effective chemotherapy alternatives.
{"title":"Protein profiles of Akt, STAT-3, NF-κB, and TLR4 in human chondrosarcoma cells: Potential therapeutic targets of insulin signaling pathway -","authors":"S. Akyol, S. Yuksel, M. A. Gulec, Þemsettin Þahin, K. Demircan, O. Akyol, H. Ozyurt","doi":"10.5455/JEIM.170316.OR.149","DOIUrl":"https://doi.org/10.5455/JEIM.170316.OR.149","url":null,"abstract":"Objectives: Currently there is no effective chemotherapy for chondrosarcoma. Recent studies report that mesenchymal chondrosarcoma is relatively resistant to radiotherapy but sensitive to chemotherapy in some extend. It is unknown whether receptor tyrosine kinase is activated in chondrosarcoma. Potential new systemic treatment targets have been widely investigated. This study aimed to determine insulin-induced phosphorylation rate of signal proteins Akt, STAT-3, NF-κB and TLR4 by using Western Blot technique to find out a possible therapeutic target for human chondrosarcoma. Methods: Human chondrosarcoma cells (OUMS-27) were induced by 10 μmol/mL insulin for 60 min. The first group was untreated control group, while the others were insulin-induced groups for 10, 30, and 60 min by applying same amount of insulin. After the induction periods, cells were harvested and protein extractions were performed. Phosphorylated and unphosphorylated individual protein levels were detected. Results: Both pSTAT-3/STAT-3 and pNF-κB/NF-κB ratios were found to be remarkably increased (almost 3-fold) in 60 min group (almost 3-fold) compared those of controls. Conclusions: The mechanism of insulin action in OUMS-27 chondrosarcoma cell lines and other human chondrosarcomas has not yet been illuminated. According to our findings, STAT-3 and/or NF-κB could be intracellular molecules that transmit the message of insulin to inside of OUMS-27 cells. Especially the fact that the phosphorylated forms of these proteins increase 3 times after 60 minutes of the insulin induction supports our perspective. These signaling molecules might be considered as potential targets of effective chemotherapy alternatives.","PeriodicalId":16091,"journal":{"name":"Journal of Experimental and Integrative Medicine","volume":"20 1","pages":"6-11"},"PeriodicalIF":0.0,"publicationDate":"2016-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81548812","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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