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Sex Determination from Radiological Assessment of the Sacrum in Nepalese Population: A Cross-sectional Study 尼泊尔人群骶骨放射评估的性别决定:一项横断面研究
Pub Date : 2020-12-22 DOI: 10.22502/JLMC.V8I2.393
Subina Shrestha, S. Kc, S. Acharya
Introduction: Human skeleton shows variable degree of sexual dimorphism, but definitive inference can be obtained from only a few bones, sacrum being one of them. The morphometric differences of the bone will be helpful to obstetricians, as it shows special adaptations in females for child bearing. It is also important for physical anthropologists and forensic scientists for sex determination. The aim of this study was to find out whether sex could be determined by using sacral parameters from X-ray images of pelvis. Methods: The study included antero-posterior X-ray images of pelvis with clearly visible 680 sacra (311 of males and 369 of females) obtained by computer generated random numbers from records in the Department of Radiodiagnosis of a medical college in Nepal. X-ray images with the sacrum suspected for fractures and pathological diseases were excluded. Inbuilt software “CR Konica Minolta Aero DR/CR CS7” was used for measurements. Results: The mean sacral length and mean transverse diameter of S1 vertebra were higher in males; whereas, mean sacral breadth, mean left ala length, mean right ala length, mean ala length, mean sacral index and mean alar index were higher in females. These differences in sacral parameters between the two sexes were statistically significant (p<0.05). The percentage of bones identified by demarking points of sacral index was 15.17% and 0.32% respectively in the males and the females. Conclusion: The result of the present study supported determination of sex of an individual from radiological assessment of sacrum.
简介:人类骨骼表现出不同程度的两性异形,但只能从少数骨骼中得出明确的推断,骶骨就是其中之一。骨骼的形态计量差异将有助于产科医生,因为它显示出女性对生育的特殊适应。对于体质人类学家和法医学家来说,性别鉴定也很重要。本研究的目的是找出是否可以通过使用骨盆X射线图像中的骶骨参数来确定性别。方法:该研究包括通过计算机生成的随机数从尼泊尔一所医学院放射诊断系的记录中获得的具有清晰可见的680骶骨(男性311例,女性369例)的骨盆前后X射线图像。骶骨的X射线图像被怀疑有骨折和病理性疾病被排除在外。使用内置软件“CR Konica Minolta Aero DR/CR CS7”进行测量。结果:男性S1椎骨的平均骶骨长度和平均横径较高;女性的平均骶骨宽度、平均左额长度、平均右额长度、总额长度、骶骨指数和平均额指数均较高。两种性别的骶骨参数差异具有统计学意义(p<0.05)。通过骶骨指数标记点识别的骨骼百分比在男性和女性中分别为15.17%和0.32%。结论:本研究的结果支持通过骶骨的放射学评估来确定个体的性别。
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引用次数: 0
‘Publish or Perish’ Trend: Fueling the Predatory Journals “出版或灭亡”趋势:助长掠夺性期刊
Pub Date : 2020-12-16 DOI: 10.22502/JLMC.V8I2.409
A. Atreya
In the past, journals were published only in the print, and the only way to access them was through the library. However, today we can easily access journals and articles with a click. There are more online journals which have made it possible and feasible for authors to submit their work. As an editor of a journal, I am often approached by younger aspiring authors for accelerated publication of their manuscripts. The journal is biannual and undergoes double-blind peer review process which in itself is time consuming. The authors also fear the reviewer’s comment about major corrections or even rejection of their article. The criteria of mandatory publication for academic promotion has compelled medical professionals to write and publish research articles. To get their articles published quick and easy, they sometimes fall prey to predatory journals. The ‘Publish or Perish’ trend should be discouraged and young researchers should be mentored and encouraged to publish in good impact journals.
过去,期刊只以印刷品的形式出版,访问它们的唯一途径是通过图书馆。然而,今天我们只需点击一下就可以轻松访问期刊和文章。越来越多的在线期刊使作者提交作品成为可能和可行的。作为一名期刊编辑,年轻有抱负的作家经常找我,要求我加快出版他们的手稿。该期刊每半年出版一次,并进行双盲同行评审,这本身就很耗时。作者们还担心评论者对他们文章的重大更正甚至拒绝发表评论。学术晋升的强制性出版标准迫使医学专业人员撰写和发表研究文章。为了让他们的文章快速轻松地发表,他们有时会成为掠夺性期刊的牺牲品。应该劝阻“要么发表,要么冒险”的趋势,应该指导和鼓励年轻的研究人员在有影响力的期刊上发表文章。
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引用次数: 0
Perception of Educational Environment among Nursing Students of Different Colleges: A Cross- Sectional Study 不同院校护生对教育环境感知的横断面研究
Pub Date : 2020-12-09 DOI: 10.22502/JLMC.V8I2.403
C. K. Garbuja, Sunita Rana, P. Thapa, Mohan Singh Rana
Introduction: Learners are key figures for whom the provision and perception of positive, progressive and encouraging interactive educational environment at any educational institution is very crucial. The study aimed to find the perception of nursing students of two different medical colleges regarding their educational environment. Methods: A cross-sectional descriptive study was conducted among 190 students through the use of internationally validated, non-culturally specific questionnaire. The responses were made on five points Likert scale scored from 0 to 4. The overall score was interpreted as very poor, plenty of problems, more positive than negative and excellent based on obtained score of 0-50, 51-100, 101-150 and 151-200 respectively. Descriptive statistics and one way analysis of variance test was used to analyze the collected data. Results: There were 98 (51.6%) participants from College of Medical Sciences and 92 (48.4%) from Lumbini Medical College and Teaching Hospital. The overall score of perception of educational environment were 142.13±14.90 (74.64%) and 144.34±15.59 (76.14%) in the two centers respectively which means more positive than negative perceptions. Only nature of accommodation was found statistically significant with students’ perception of teachers (p = 0.014). Conclusion: Majority opined a more positive than negative perception towards educational environment. Good communication skills of teachers, knowledgeable teachers, teaching to develop their competence level were some positive perceptions. Whereas, teachers being authoritarian, focus on short term and factual learning, lack of support system were the areas which could be improved.
学习者是关键人物,对他们来说,在任何教育机构中,提供和感知积极、进步和鼓励的互动教育环境都是至关重要的。本研究旨在了解两所不同医学院护生对教育环境的感受。方法:对190名学生进行横断面描述性研究,采用国际认可的、非文化特异性问卷。回答是在李克特量表上从0到4分的5分中做出的。综合得分为0-50分、51-100分、101-150分、151-200分,分别为“很差”、“问题多”、“正面多于负面”和“优秀”。采用描述性统计和单因素方差分析检验对收集到的资料进行分析。结果:医学院98人(51.6%),兰毗尼医学院及教学医院92人(48.4%)。两中心学生对教育环境的总体感知得分分别为142.13±14.90分(74.64%)和144.34±15.59分(76.14%),积极感知高于消极感知。只有住宿性质与学生对教师的看法有统计学意义(p = 0.014)。结论:大多数学生对教育环境的看法是积极的,而不是消极的。对教师沟通能力好、教师知识渊博、教学能力发展水平高的教师给予积极评价。教师专断、注重短期学习、注重事实学习、缺乏支持系统等方面有待改进。
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引用次数: 0
Reproductive Health Issues and Use of Family Planning Methods among Married Adolescent Mothers 已婚少女母亲的生殖健康问题和计划生育方法的使用
Pub Date : 2020-12-03 DOI: 10.22502/JLMC.V8I2.404
S. Nepal, S. Aryal
Introduction: Adolescent pregnancy is a major public health concern in low- and middle-income countries. Nepal ranks among the twenty countries with the highest child marriage rates in the world. Adolescent mothers are at higher risk for poorer maternal and neonatal outcomes. This study intended to find the reproductive health issues and use of family planning methods among married adolescent mothers at a tertiary care center in a western part of Nepal. Methods: This was a cross-sectional study conducted among adolescent mothers who attended the family planning counseling session at Community Medicine Out-patient Department at a tertiary care center. Pre-tested semi-structured questionnaire was used for data collection and variables were entered in SPSSTM version 16. Descriptive statistics were presented in terms of mean and percentage. Results: Among 235 adolescent mothers, the mean age of adolescent mothers was 18.02 years (SD = 1.13). Almost 93.2% had not used any kind of contraceptive methods previously. Limited knowledge, uncomfortable talking about contraception and spousal denial were common reasons for not using contraception. Obstetric related complications were observed in 13.6% and one in ten neonates required neonatal intensive care unit admission during the study period. After the counseling session, six out of ten expressed current choice of long-acting reversible contraceptives method in which Jadelle implant was preferred. Conclusion: Our study among the adolescent mothers showed that use of family planning methods before pregnancy had been very low. Policies need to focus on meeting the unmet need for family planning among married adolescent girls.
引言:青少年怀孕是中低收入国家的一个主要公共卫生问题。尼泊尔是世界上童婚率最高的20个国家之一。青春期母亲的产妇和新生儿结局较差的风险更高。这项研究旨在了解尼泊尔西部一家三级护理中心已婚青少年母亲的生殖健康问题和计划生育方法的使用情况。方法:这是一项横断面研究,对象是参加三级护理中心社区门诊部计划生育咨询会议的青少年母亲。采用预测半结构化问卷进行数据收集,并在SPSSTM版本16中输入变量。描述性统计以平均值和百分比表示。结果:在235名青春期母亲中,青春期母亲的平均年龄为18.02岁(SD=1.13),近93.2%的母亲以前没有使用过任何避孕方法。知识有限、谈论避孕方法时感到不舒服以及配偶拒绝避孕是不使用避孕方法的常见原因。在研究期间,13.6%的新生儿出现产科相关并发症,十分之一的新生儿需要入住新生儿重症监护室。咨询会议结束后,十分之六的人表示目前选择的长效可逆避孕方法是首选Jadelle植入物。结论:我们对青春期母亲的研究表明,怀孕前计划生育方法的使用率很低。政策需要侧重于满足已婚少女未得到满足的计划生育需求。
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引用次数: 1
Study of Association Between Glycated Hemoglobin and Lipid Profile in Type 2 Diabetes Mellitus in Tertiary Care Center 三级医疗中心2型糖尿病患者糖化血红蛋白与血脂关系的研究
Pub Date : 2020-12-02 DOI: 10.22502/JLMC.V8I2.387
Tilchan Pandey, Jivan Khanal, Krishna Chandra Godar
Introduction: Diabetes is one of the major burdens of non-communicable disease causing morbidity and mortality. Glycated hemoglobin (HbA1c) has been used as a tool to monitor glycemic control in patients with type 2 diabetes mellitus and elevated HbA1c value is considered an independent risk factor for dyslipidemia. Methods: A total of 120 patients with type 2 diabetes mellitus were enrolled in this cross-sectional study. Means with standard deviation were used for age, height, weight and fasting blood sugar and Pearson correlation test was applied to identify correlation between Glycated hemoglobin (HbA1c) and lipid profile. Comparison of means was done by Z test in parametric data within the two groups. P value less than 0.05 was considered significant. Results: The mean HbA1c of male and female patients were 8.35±1.77 and 8.65±1.95 respectively. Among patients with good glycemic control, mean total cholesterol and mean high density lipoprotein were higher than poor glycemic control patients. Patients with poor glycemic control had higher mean triglyceride and low density lipoprotein than good glycemic control patients. Correlation coefficient for various components of lipid profile and HbA1c were: total cholesterol (r=0.189, p=0.038, n=120), triglyceride (r=0.418, p<0.01, n=120), low density lipoprotein (r=0.673,p<0.01,n=120) and high density lipoprotein ( r=-0.683, p<0.01, n=120). Conclusion: There was a significant moderate correlation between HbA1c and lipid profile. Lipid profile values were significantly higher in poor glycemic control than good glycemic control patients. Hence, HbA1c can be considered as a surrogate marker for dyslipidemia in type 2 DM patients.
导言:糖尿病是导致发病率和死亡率的非传染性疾病的主要负担之一。糖化血红蛋白(HbA1c)已被用作监测2型糖尿病患者血糖控制的工具,HbA1c升高被认为是血脂异常的独立危险因素。方法:对120例2型糖尿病患者进行横断面研究。年龄、身高、体重和空腹血糖采用标准差均值,采用Pearson相关检验确定糖化血红蛋白(HbA1c)与血脂的相关性。两组参数数据均值比较采用Z检验。P值小于0.05为显著性。结果:男性和女性患者的平均HbA1c分别为8.35±1.77和8.65±1.95。血糖控制良好的患者平均总胆固醇和平均高密度脂蛋白高于血糖控制不佳的患者。血糖控制较差的患者的平均甘油三酯和低密度脂蛋白高于血糖控制良好的患者。血脂各组分与HbA1c的相关系数分别为:总胆固醇(r=0.189, p=0.038, n=120)、甘油三酯(r=0.418, p<0.01,n=120)、低密度脂蛋白(r=0.673,p<0.01,n=120)、高密度脂蛋白(r= -0.683, p<0.01,n=120)。结论:HbA1c与血脂有显著的中度相关性。血糖控制不良的患者血脂值明显高于血糖控制良好的患者。因此,HbA1c可作为2型糖尿病患者血脂异常的替代指标。
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引用次数: 1
Microscopic Antegrade Parotidectomy for Different Types of Parotid Tumor 显微顺行腮腺切除术治疗不同类型腮腺肿瘤
Pub Date : 2020-11-05 DOI: 10.22502/JLMC.V8I2.338
Brihaspati Sigdel, T. Dubey
Introduction: Salivary gland tumor accounts for about 5% of all the neoplasms of the head and neck. 75% of such tumors occur in the parotid glands. Pleomorphic adenoma is the most common type of benign salivary gland tumor. It tends to recur after inappropriate treatment. Surgery of parotid tumor includes enucleation, superficial parotidectomy and total parotidectomy. Identification and preservation of facial nerve trunk and its branches are very important in parotid surgery. Advancement of microsurgical technique has helped in better visualization, identification and preservation of the facial nerve. Methods: This prospective study included twenty-seven patients. Preoperative ultrasonography and fine needle aspiration cytology were done for all cases. Computed tomography/magnetic resonance imaging were performed in some cases when needed. Standard microsurgical technique with the help of microscope was performed for antegrade parotidectomy. Data analysis was done using SPSS version 26.0. Results: The patients' age ranged from 12 to 78 years. Fifteen (55.6%) patients were female and 12 (44. 4%) were males. Sixteen (59.3%) tumors were located on the right side whereas 11 (40.7%) were on the left side. Most of the tumors (n=18, 66.7%) were pleomorphic adenoma. Two (7.4%) of the patients had temporary facial paralysis which improved with time. Two (7.4%) patients had developed hematoma. Frey’s syndrome was not found in follow-up. Conclusion: This study showed low morbidity in parotidectomy using microsurgical techniques. No permanent injury to the facial nerve was found.
简介:涎腺肿瘤约占头颈部肿瘤的5%。75%的此类肿瘤发生在腮腺。多形性腺瘤是涎腺良性肿瘤中最常见的类型。治疗不当易复发。腮腺肿瘤的手术包括腮腺摘除术、腮腺浅表切除术和腮腺全切除术。面神经干及其分支的识别和保存在腮腺手术中具有重要意义。显微外科技术的进步有助于更好地显示、识别和保存面神经。方法:这项前瞻性研究包括27名患者。所有病例均行术前超声检查和细针穿刺细胞学检查。在某些情况下需要进行计算机断层扫描/磁共振成像。标准显微外科技术在显微镜的帮助下进行顺行腮腺切除术。数据分析采用SPSS 26.0版软件进行。结果:患者年龄12~78岁。女性患者15例(55.6%)。4%)为男性。16个(59.3%)肿瘤位于右侧,而11个(40.7%)位于左侧。大多数肿瘤(n=18,66.7%)为多形性腺瘤。两名(7.4%)患者出现暂时性面瘫,随着时间的推移病情有所好转。两名(7.4%)患者出现血肿。随访中未发现弗雷综合征。结论:本研究显示应用显微外科技术进行腮腺切除术的发病率较低。面部神经未发现永久性损伤。
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引用次数: 0
Bacteriological Profile of Wound Infection and Antibiotic Susceptibility Pattern of Various Isolates in a Tertiary Care Center 某三级医疗中心伤口感染的细菌学特征及不同分离株的抗生素敏感性
Pub Date : 2020-10-29 DOI: 10.22502/JLMC.V8I2.367
Nabina Maharjan, B. S. Mahawal
Introduction: Wound infection due to various pathogenic microorganisms and the development of resistance to antibiotics is one of the major problems in medical sector. This study aimed to identify the etiological agents of wound infection along with their antibiotic susceptibility. Methods: A total of 400 wound swab specimens were collected from the patients visiting a tertiary center in western Nepal over a period of six months. Thus, collected specimens were processed in Microbiology laboratory for isolation of causative agents. Antibiotic susceptibility test was performed for entire isolates by Kirby Baur disc diffusion method. Methicillin-Resistant Staphylococcus aureus was detected by cefoxitin disc diffusion test and Extended- Spectrum Beta-Lactamases producing Enterobacteriaeae by Phenotypic confirmatory disc diffusion test as recommended by Clinical and Laboratory Standards Institute. Results: Two hundred and fifty-nine (64.7%) of specimens were infected, giving rise to 269 different isolates. Among these, 166 (61.7%) were gram positive and 101 (37.6%) were gram negative bacteria. Staphylococcus aureus (n = 130, 48.3%) was the most predominant bacteria followed by Escherichia coli (n=44, 16.3%), and Klebsiella pneumoniae (n=23, 8.5%). Gentamicin followed by co-trimoxazole was the most effective among the tested antibiotics for Staphylococcus aureus. Gentamicin and ciprofloxacin were shown effective for isolated gram-negative bacteria. Conclusion: Fifty-eight (44.6%) of total Staphylococcus aureus were Methicillin-Resistant Staphylococcus aureus positive and 16 (20.7%) of total Enterobacteriaceae were Extended-Spectrum Beta-Lactamases producers. The increased prevalence of Methicillin-Resistant Staphylococcus aureus and Extended-Spectrum Beta-Lactamase suggest rational use of antibiotics on the basis of antibiotic sensitivity results.
导读:各种病原微生物引起的伤口感染和抗生素耐药性的发展是医疗领域的主要问题之一。本研究旨在确定伤口感染的病原及其抗生素敏感性。方法:在6个月的时间里,从尼泊尔西部三级医疗中心就诊的患者中收集了400份伤口拭子标本。因此,收集的标本在微生物实验室进行处理,以分离病原体。采用Kirby Baur圆盘扩散法对全株进行药敏试验。采用头孢西丁圆盘扩散试验检测耐甲氧西林金黄色葡萄球菌,采用临床与实验室标准协会推荐的增谱β -内酰胺酶产肠杆菌采用表型确证型圆盘扩散试验检测耐甲氧西林金黄色葡萄球菌。结果:感染标本259份(64.7%),分离菌株269株。其中革兰阳性166例(61.7%),革兰阴性101例(37.6%)。以金黄色葡萄球菌(130株,48.3%)为主,其次为大肠埃希菌(44株,16.3%)和肺炎克雷伯菌(23株,8.5%)。对金黄色葡萄球菌最有效的抗生素是庆大霉素,其次是复方新诺明。庆大霉素和环丙沙星对分离的革兰氏阴性菌有效。结论:耐甲氧西林金黄色葡萄球菌阳性菌58株(44.6%),产广谱β -内酰胺酶菌16株(20.7%)。耐甲氧西林金黄色葡萄球菌和广谱β -内酰胺酶的流行率增加提示应根据抗生素敏感性结果合理使用抗生素。
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引用次数: 5
Comparison of External Fixation and Supplementary Kirschner-Wires Fixation With Volar Locking Plate for the Treatment of Intra- Articular Distal End Radius Fractures Volar锁定钢板外固定与Kirschner钢丝辅助固定治疗桡骨远端关节内骨折的比较
Pub Date : 2020-10-21 DOI: 10.22502/JLMC.V8I2.397
R. Dwivedi, M. Khatri, Arjun Kc
Introduction: There are controversies regarding the benefit of open reduction and internal fixation with volar locking plates over closed reduction and external fixation along with supplementary Kirschner wires fixation for intra-articular distal end radius fracture. Therefore, this study aimed to compare the outcomes between external fixation along with supplementary Kirschner wires with volar locking plate in the treatment of intra-articular distal end radius fractures. Methods: This prospective, observational and analytical study was conducted over one and a half years. Forty-seven adults with displaced intra-articular distal end radius fracture were included in the study. Twenty-one cases were treated with closed reduction and external fixation along with supplementary Kirschner wires, whereas 26 patients were treated with open reduction and volar locking plate fixation. Results: At the end of three months, as per the Green and O’Brien scoring, the mean functional outcome score in the volar plate group was significantly better 80.77(±11.46) than the external fixation group 70.24(±10.66) (p=0.002). However, at the end of six months, the mean score in the volar plate group 86.15(±7.39) was not significantly different from the external fixation group 81.43(±9.63) (p= 0.63). Fracture reduction was achieved and maintained better in the volar locking plate group. Conclusion: Functional outcome of closed reduction and external fixation along with supplementary Kirschner wires is comparable with open reduction and internal fixation by volar locking plate in treatment of displaced intra-articular distal radius fractures. Radiological correction is achieved and maintained better with volar locking plates.
导读:对于桡骨远端关节内骨折,开放复位和掌侧锁定钢板内固定优于闭合复位和外固定并辅助克氏针内固定存在争议。因此,本研究旨在比较外固定带克氏针辅助掌侧锁定钢板治疗桡骨远端关节内骨折的效果。方法:这项前瞻性、观察性和分析性研究进行了一年半。47例成人桡骨远端关节内移位骨折纳入研究。21例采用闭合复位外固定联合克氏针,26例采用开放复位和掌侧锁定钢板固定。结果:三个月后,根据Green和O 'Brien评分,掌侧钢板组的平均功能结局评分为80.77(±11.46)分,显著优于外固定组70.24(±10.66)分(p=0.002)。6个月后,掌侧钢板组平均评分86.15(±7.39)分与外固定架组81.43(±9.63)分差异无统计学意义(p= 0.63)。掌侧锁定钢板组骨折复位和维持较好。结论:桡骨远端移位性关节内骨折采用克氏针辅助闭合复位外固定与掌侧锁定钢板切开复位内固定疗效相当。使用掌侧锁定钢板可以更好地实现和维持放射矫正。
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引用次数: 0
Medication Adherence Pattern for Benign Prostatic Hyperplasia: A Cross-Sectional Study 良性前列腺增生的药物依从模式:一项横断面研究
Pub Date : 2020-10-01 DOI: 10.22502/JLMC.V8I2.386
J. Shrestha, H. Joshi, P. Neupane
Introduction: Benign prostate hyperplasia is one of the most common diseases and a common cause of lower urinary tract symptoms in aging men. Various disease management approaches to optimize the patient’s long life and efficient status where patient adherence to the prescribed treatment plays a vital role. This study evaluated the medication adherence pattern of the patients to obtain successful treatment outcomes. Methods: A cross-sectional study was conducted in out-patient department of urology in a tertiary care hospital. Patients diagnosed with benign prostate hyperplasia were interviewed using a structured questionnaire. Results: The high expenses of medicine, fear of medication, lack of symptomatic relief were factors that showed statistically significant (p < 0.05) difference between adherent and non-adherent group. Similarly, the duration of diagnosis of the adherent group was significantly less than the non-adherent group including the pattern of physical activities (p < 0.05). Adherent group also had more participants working in business and services occupation compared to the non-adherent group. Conclusion: The general attitude (such as fear of medication and lack of symptomatic relief) is seen as major factors that affect adherent pattern in benign prostate hyperplasia patients. These issues can be solved using proper guidance. However, the cost of medicines also posts an immense issue for the non-adherent group.
简介:良性前列腺增生是老年男性最常见的疾病之一,也是引起下尿路症状的常见原因。各种疾病管理方法可优化患者的长寿命和有效状态,其中患者对处方治疗的坚持发挥着至关重要的作用。本研究评估了患者的药物依从性模式,以获得成功的治疗结果。方法:在某三甲医院泌尿外科门诊进行横断面研究。使用结构化问卷对诊断为良性前列腺增生的患者进行访谈。结果:用药费用高、对药物的恐惧、缺乏症状缓解是粘附组与非粘附组差异有统计学意义(p<0.05)的因素。同样,坚持组的诊断持续时间(包括体力活动模式)明显少于非坚持组(p<0.05)。与非坚持组相比,坚持组从事商业和服务职业的参与者也更多。结论:一般态度(如对药物的恐惧和缺乏症状缓解)是影响良性前列腺增生患者粘附模式的主要因素。这些问题可以通过适当的指导来解决。然而,药品成本也给不遵守规定的群体带来了巨大的问题。
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引用次数: 0
The Role of Aspartate Aminotransferase to Platelet Ratio Index as a Non-Invasive Predictor of Variceal Etiology of Upper Gastrointestinal Bleeding 天门冬氨酸转氨酶对血小板比率指数作为上消化道出血静脉曲张病因的无创预测因子的作用
Pub Date : 2020-09-20 DOI: 10.22502/JLMC.V8I2.376
A. Shrestha, P. Sharma, A. Lama, R. Gurung
Introduction: Non-invasive strategies to predict variceal from non-variceal bleeding will be highly beneficialfor preemptive management of Upper Gastrointestinal Bleeding (UGIB). This study aimed to assess the roleof aspartate aminotransferase (AST) to platelet ratio index (APRI) as a non-invasive predictor of varicealetiology of UGIB. Methods: This was a retrospective descriptive study conducted at Endoscopy Departmentof Dhulikhel Hospital between January 2017 and December 2019 in patients presenting with acute UGIB.We assessed the diagnostic utility of the APRI score relative to other objective measures by Area Under theReceiver Operating Characteristic (AUROC) curve analysis. Results: A total of 158 patients with historyof UGIB were included in the study. There were total 123 males (77.8%) and the mean age of the patientswas 50.3±16.1 years. The APRI score performed well in predicting a variceal etiology of acute UGIB, withAUROC 0.9. When APRI was used at cut-off of 1.3, it had a sensitivity of 84.1% and specificity of 76.8%,a positive predictive value of 70.7% and a negative predictive value of 89.9% while predicting varicealetiology of UGIB at presentation. The relative risk of varices at an APRI cut-off of 1.3 is 17.5 with a p-valueof <0.0001. Conclusion: The present study highlighted that APRI score can be used as an objective metricthat helps to predict a variceal etiology of acute UGIB.
引言:从非静脉曲张破裂出血预测静脉曲张破裂的非侵入性策略将对上消化道出血(UGIB)的早期治疗非常有益。本研究旨在评估天冬氨酸转氨酶(AST)与血小板比值指数(APRI)作为UGIB静脉曲张破裂病的非侵入性预测指标的作用。方法:这是一项回顾性描述性研究,于2017年1月至2019年12月在Dhulikhel医院内镜科对急性UGIB患者进行。我们通过受试者操作特征面积(AUROC)曲线分析,评估了APRI评分相对于其他客观指标的诊断效用。结果:本研究共纳入158例UGIB患者。共有123名男性(77.8%),患者的平均年龄为50.3±16.1岁。APRI评分在预测急性UGIB的静脉曲张病因方面表现良好,AUROC为0.9。当APRI在1.3的临界值下使用时,它在预测UGIB的水痘发病时的敏感性为84.1%,特异性为76.8%,阳性预测值为70.7%,阴性预测值为89.9%。APRI临界值为1.3时发生静脉曲张的相对风险为17.5,p值<0.0001。结论:本研究强调APRI评分可作为一种客观指标,有助于预测急性UGIB的静脉曲张病因。
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Journal of Lumbini Medical College
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