Rohit K. Menon, Li Kar Yan, Divya Gopinath, Michael G. Botelho
Aim
Randomized controlled trials might be reporting a higher postoperative infection rate for third molar surgery compared to other study designs due to unclear criteria for the classification of “infections”. The aim of the present retrospective study was to assess the infection rate after third molar surgery with and without postoperative antibiotic prescription.
Methods
Case records of patients who underwent third molar extractions at the Prince Philip Dental Hospital in Hong Kong between 3 July 2012 and 22 June 2017 were evaluated retrospectively. Data extraction was performed for indications, clinical and radiographic findings, antibiotic treatment, postoperative complications, and treatment for postoperative infection. The odds ratio (OR) for postoperative infection was estimated.
Results
In total, 1615 extracted over 5 years from 992 patient records were included in the final analysis. Antibiotics were prescribed postoperatively for 44% of the extractions. The overall infection rate was 2.05%. There was no significant difference in infection rates between the groups which underwent extractions with or without antibiotics (OR = .68; P =.289). We found a significantly higher risk for infections with increasing age (P =.002).
Conclusion
Infection rates after third molar extraction is minimal in the current setting, with no significant benefit from postoperative antibiotic prescription.
{"title":"Is there a need for postoperative antibiotics after third molar surgery? A 5-year retrospective study","authors":"Rohit K. Menon, Li Kar Yan, Divya Gopinath, Michael G. Botelho","doi":"10.1111/jicd.12460","DOIUrl":"10.1111/jicd.12460","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Aim</h3>\u0000 \u0000 <p>Randomized controlled trials might be reporting a higher postoperative infection rate for third molar surgery compared to other study designs due to unclear criteria for the classification of “infections”. The aim of the present retrospective study was to assess the infection rate after third molar surgery with and without postoperative antibiotic prescription.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Case records of patients who underwent third molar extractions at the Prince Philip Dental Hospital in Hong Kong between 3 July 2012 and 22 June 2017 were evaluated retrospectively. Data extraction was performed for indications, clinical and radiographic findings, antibiotic treatment, postoperative complications, and treatment for postoperative infection. The odds ratio (OR) for postoperative infection was estimated.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>In total, 1615 extracted over 5 years from 992 patient records were included in the final analysis. Antibiotics were prescribed postoperatively for 44% of the extractions. The overall infection rate was 2.05%. There was no significant difference in infection rates between the groups which underwent extractions with or without antibiotics (OR = .68; <i>P </i>=<i> </i>.289). We found a significantly higher risk for infections with increasing age (<i>P </i>=<i> </i>.002).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Infection rates after third molar extraction is minimal in the current setting, with no significant benefit from postoperative antibiotic prescription.</p>\u0000 </section>\u0000 </div>","PeriodicalId":16204,"journal":{"name":"Journal of Investigative and Clinical Dentistry","volume":"10 4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-10-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1111/jicd.12460","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46499806","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The present study aims to evaluate the efficacy and safety of curcumin in both topical and systemic forms for management of oral submucous fibrosis in comparison with the antioxidants.
Methods
In this randomized parallel-group single-center trial, 119 patients were enrolled. Group I received antioxidants, group II received curcumin in systemic form and group III received curcumin in both systemic and topical forms. The primary outcomes assessed were interincisal mouth opening and burning sensation using a visual analog scale. The secondary outcomes were tongue protrusion and adverse reactions. The response to treatment was analyzed using ANOVA and Fisher's exact test.
Results
Significant improvement in mouth opening, burning sensation and tongue protrusion was observed in all groups at 12 weeks. Mean improvement in burning sensation did not show statistical difference across the groups. A significant difference between groups II and III for improvement in mouth opening and groups I and III for improvement in tongue protrusion was noted.
Conclusion
When administrated in both systemic and topical forms together, curcumin showed better results in the management of oral submucous fibrosis as compared with the systemic form alone or antioxidants. Curcumin has the potential to emerge as an effective alternative to conventionally prescribed medications.
{"title":"Comparative evaluation of curcumin and antioxidants in the management of oral submucous fibrosis","authors":"Arpita Rai, Mandeep Kaur, Virender Gombra, Shamimul Hasan, Narender Kumar","doi":"10.1111/jicd.12464","DOIUrl":"10.1111/jicd.12464","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Aim</h3>\u0000 \u0000 <p>The present study aims to evaluate the efficacy and safety of curcumin in both topical and systemic forms for management of oral submucous fibrosis in comparison with the antioxidants.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>In this randomized parallel-group single-center trial, 119 patients were enrolled. Group I received antioxidants, group II received curcumin in systemic form and group III received curcumin in both systemic and topical forms. The primary outcomes assessed were interincisal mouth opening and burning sensation using a visual analog scale. The secondary outcomes were tongue protrusion and adverse reactions. The response to treatment was analyzed using ANOVA and Fisher's exact test.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Significant improvement in mouth opening, burning sensation and tongue protrusion was observed in all groups at 12 weeks. Mean improvement in burning sensation did not show statistical difference across the groups. A significant difference between groups II and III for improvement in mouth opening and groups I and III for improvement in tongue protrusion was noted.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>When administrated in both systemic and topical forms together, curcumin showed better results in the management of oral submucous fibrosis as compared with the systemic form alone or antioxidants. Curcumin has the potential to emerge as an effective alternative to conventionally prescribed medications.</p>\u0000 </section>\u0000 </div>","PeriodicalId":16204,"journal":{"name":"Journal of Investigative and Clinical Dentistry","volume":"10 4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-10-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1111/jicd.12464","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48400134","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
In the present study, we aimed to identify and analyze the characteristics of highly cited articles in dentistry.
Methods
All articles belonging to Web of Science category of “dentistry, oral surgery and medicine” published until 2016 were analyzed. The bibliometric data of the highly cited articles were evaluated. The Y-index was applied to assess authors’ publication potential. Altmetric scores were recorded from Dimensions, a free online database.
Results
There were 3666 highly cited dentistry articles published in dental journals. Half of them were published in seven leading journals in their specialties. The major contributing countries were the USA, Sweden, the UK, and Switzerland. The highly cited articles were written by 3.7 authors on average. Jan Lindhe had the largest number of highly cited articles, whereas David H. Pashley had the highest potential to publish highly cited articles in dentistry.
Conclusions
Highly cited articles were distributed among various dental specialties, and the most productive periods were the late 1990s and the early 2000s. The Y-index gave dimensional details of the prolific authors. The current analysis was based on data extracted from Web of Science. Results could be different if data were extracted from other databases, such as Google Scholar.
{"title":"Highly cited dental articles and their authors: An evaluation of publication and citation characteristics","authors":"Andy Wai Kan Yeung, Yuh-Shan Ho","doi":"10.1111/jicd.12462","DOIUrl":"10.1111/jicd.12462","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Aim</h3>\u0000 \u0000 <p>In the present study, we aimed to identify and analyze the characteristics of highly cited articles in dentistry.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>All articles belonging to Web of Science category of “dentistry, oral surgery and medicine” published until 2016 were analyzed. The bibliometric data of the highly cited articles were evaluated. The Y-index was applied to assess authors’ publication potential. Altmetric scores were recorded from Dimensions, a free online database.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>There were 3666 highly cited dentistry articles published in dental journals. Half of them were published in seven leading journals in their specialties. The major contributing countries were the USA, Sweden, the UK, and Switzerland. The highly cited articles were written by 3.7 authors on average. Jan Lindhe had the largest number of highly cited articles, whereas David H. Pashley had the highest potential to publish highly cited articles in dentistry.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Highly cited articles were distributed among various dental specialties, and the most productive periods were the late 1990s and the early 2000s. The Y-index gave dimensional details of the prolific authors. The current analysis was based on data extracted from Web of Science. Results could be different if data were extracted from other databases, such as Google Scholar.</p>\u0000 </section>\u0000 </div>","PeriodicalId":16204,"journal":{"name":"Journal of Investigative and Clinical Dentistry","volume":"10 4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-10-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1111/jicd.12462","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49149740","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Bobby K. Joseph, Mohammad A. Ali, Hussain Dashti, Devipriya B. Sundaram
Aims
The aim of the present study was to determine the range, frequency, prevalence, and distribution of oral lesions submitted for histopathological diagnosis at the oral pathology laboratory at Kuwait University.
Methods
A retrospective analysis was conducted of all cases submitted to the oral pathology laboratory over an 18-year period. Age, sex, histopathological diagnosis, and location of the lesions were recorded. Lesions were classified into 10 diagnostic categories.
Results
Of the 697 biopsies examined, the average age of the patients ranged from 1 to 93 years with a mean age of 37.83 ± 16.62 (mean ± SD). The most common diagnostic category was mucosal pathologies (N = 205, 29.4%), followed by odontogenic cysts (N = 158, 22.7%) and reactive lesions (N = 97, 13.9%). The three most common histopathological diagnoses were hyperkeratosis (N = 70), dentigerous cyst (N = 48), and mucocele (N = 44). Twenty-five malignant neoplasms were diagnosed, the majority of them in males. A significant association was observed between age and the group of lesions of the oral cavity (P ≤ 0.001).
Conclusions
The present study provides the first set of data from Kuwait that covers a wide range of oral lesions. Mucosal pathologies were the most frequently diagnosed lesions and the majority of diagnoses were benign.
{"title":"Analysis of oral and maxillofacial pathology lesions over an 18-year period diagnosed at Kuwait University","authors":"Bobby K. Joseph, Mohammad A. Ali, Hussain Dashti, Devipriya B. Sundaram","doi":"10.1111/jicd.12432","DOIUrl":"10.1111/jicd.12432","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Aims</h3>\u0000 \u0000 <p>The aim of the present study was to determine the range, frequency, prevalence, and distribution of oral lesions submitted for histopathological diagnosis at the oral pathology laboratory at Kuwait University.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>A retrospective analysis was conducted of all cases submitted to the oral pathology laboratory over an 18-year period. Age, sex, histopathological diagnosis, and location of the lesions were recorded. Lesions were classified into 10 diagnostic categories.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Of the 697 biopsies examined, the average age of the patients ranged from 1 to 93 years with a mean age of 37.83 ± 16.62 (mean ± SD). The most common diagnostic category was mucosal pathologies (N = 205, 29.4%), followed by odontogenic cysts (N = 158, 22.7%) and reactive lesions (N = 97, 13.9%). The three most common histopathological diagnoses were hyperkeratosis (N = 70), dentigerous cyst (N = 48), and mucocele (N = 44). Twenty-five malignant neoplasms were diagnosed, the majority of them in males. A significant association was observed between age and the group of lesions of the oral cavity (<i>P</i> ≤ 0.001).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>The present study provides the first set of data from Kuwait that covers a wide range of oral lesions. Mucosal pathologies were the most frequently diagnosed lesions and the majority of diagnoses were benign.</p>\u0000 </section>\u0000 </div>","PeriodicalId":16204,"journal":{"name":"Journal of Investigative and Clinical Dentistry","volume":"10 4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1111/jicd.12432","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45535047","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
This paper evaluates the use of online video learning materials used for a simulation laboratory course for 2 consecutive cohorts of students using an evaluation and analytics approach.
Methods
100 online video clips were created to support students’ learning before, during and after the scheduled simulation laboratory teaching sessions in a fixed prosthodontics course. Videoed online presentations included screen-captured PowerPoint presentations, simulation laboratory psychomotor and clinical skills demonstrations, individual student case consultations and whole-class worksheet debriefings. Data files and access data were analyzed for 2 consecutive cohorts of 4th year students. An evaluation questionnaire was administered on the 2015 cohort.
Results
Feedback on learning resources were strongly positive. 100% of students reported that the videos helped in their learning, preparation for simulation laboratory classes, to refresh their memory prior to clinical care, prepare for the clinical competency test and prepare for examinations. In total, 4689 videos were accessed, 35% by class 2015 and 65% by 2016. 73% of these were watched during the simulation laboratory course, 13% were watched 2-3 weeks before examinations and 14% during the remainder of the year.
Conclusion
Videos were reported to support student learning and were valued for a range of learning needs. However, significant differences between student consumption and strategies need to be designed to engage low consumers.
{"title":"Evaluation of student use of videos to support learning in a simulation laboratory course: A perception and analytics approach","authors":"Michael G. Botelho","doi":"10.1111/jicd.12453","DOIUrl":"10.1111/jicd.12453","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Aim</h3>\u0000 \u0000 <p>This paper evaluates the use of online video learning materials used for a simulation laboratory course for 2 consecutive cohorts of students using an evaluation and analytics approach.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>100 online video clips were created to support students’ learning before, during and after the scheduled simulation laboratory teaching sessions in a fixed prosthodontics course. Videoed online presentations included screen-captured PowerPoint presentations, simulation laboratory psychomotor and clinical skills demonstrations, individual student case consultations and whole-class worksheet debriefings. Data files and access data were analyzed for 2 consecutive cohorts of 4th year students. An evaluation questionnaire was administered on the 2015 cohort.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Feedback on learning resources were strongly positive. 100% of students reported that the videos helped in their learning, preparation for simulation laboratory classes, to refresh their memory prior to clinical care, prepare for the clinical competency test and prepare for examinations. In total, 4689 videos were accessed, 35% by class 2015 and 65% by 2016. 73% of these were watched during the simulation laboratory course, 13% were watched 2-3 weeks before examinations and 14% during the remainder of the year.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Videos were reported to support student learning and were valued for a range of learning needs. However, significant differences between student consumption and strategies need to be designed to engage low consumers.</p>\u0000 </section>\u0000 </div>","PeriodicalId":16204,"journal":{"name":"Journal of Investigative and Clinical Dentistry","volume":"10 4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-09-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1111/jicd.12453","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45868664","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Arada Patarapongsanti, Panwadee Bandhaya, Benyapha Sirinirund, Sakornratana Khongkhunthian, Pathawee Khongkhunthian
Aim
The aim of the present study was to compare patient morbidity and healing outcomes of free gingival graft (FGG) harvesting at palatal donor sites and after using platelet-rich fibrin (PRF) and oxidized regenerated cellulose (ORC). FGG harvesting leaves open palatal wounds, which heal by secondary intention. Patients might experience discomfort or pain during the first 2 weeks of healing.
Methods
Eighteen participants requiring two FGG were recruited. The test and control sites were covered with PRF membrane and ORC. The complete epithelialization of the palatal wound, the percentage of wound healing, and postoperative pain were evaluated, 1, 3, and 7 days and 2, 3, and 4 weeks after surgery.
Results
Similar wound size reduction at 1 week (test: 36.87%, control: 38.78%) was found. At 2 weeks, the majority of the test group (88.89%) showed complete epithelialization, whereas 66.67% of the control group had complete epithelialization (P =.228). Pain was more prevalent in the control group (27.77%) than in the test group (11.1%) on day 1. None of the participants reported any pain or discomfort at the test sites on day 3.
Conclusions
PRF seems to reduce patient morbidity, but there is no difference in palatal wound healing (P > .05).
{"title":"Comparison of platelet-rich fibrin and cellulose in palatal wounds after graft harvesting","authors":"Arada Patarapongsanti, Panwadee Bandhaya, Benyapha Sirinirund, Sakornratana Khongkhunthian, Pathawee Khongkhunthian","doi":"10.1111/jicd.12467","DOIUrl":"10.1111/jicd.12467","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Aim</h3>\u0000 \u0000 <p>The aim of the present study was to compare patient morbidity and healing outcomes of free gingival graft (FGG) harvesting at palatal donor sites and after using platelet-rich fibrin (PRF) and oxidized regenerated cellulose (ORC). FGG harvesting leaves open palatal wounds, which heal by secondary intention. Patients might experience discomfort or pain during the first 2 weeks of healing.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Eighteen participants requiring two FGG were recruited. The test and control sites were covered with PRF membrane and ORC. The complete epithelialization of the palatal wound, the percentage of wound healing, and postoperative pain were evaluated, 1, 3, and 7 days and 2, 3, and 4 weeks after surgery.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Similar wound size reduction at 1 week (test: 36.87%, control: 38.78%) was found. At 2 weeks, the majority of the test group (88.89%) showed complete epithelialization, whereas 66.67% of the control group had complete epithelialization (<i>P </i>=<i> </i>.228). Pain was more prevalent in the control group (27.77%) than in the test group (11.1%) on day 1. None of the participants reported any pain or discomfort at the test sites on day 3.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>PRF seems to reduce patient morbidity, but there is no difference in palatal wound healing (<i>P</i> > .05).</p>\u0000 </section>\u0000 </div>","PeriodicalId":16204,"journal":{"name":"Journal of Investigative and Clinical Dentistry","volume":"10 4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-09-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1111/jicd.12467","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48860056","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Eduardo Frois Temponi, Paulo Eduardo Alencar Souza, Giovanna Ribeiro Souto, Luísa Mourão Dias Magalhães, Walderez Ornelas Dutra, Kenneth John Gollob, Tarcília Aparecida Silva, Rodrigo Villamarim Soares
Aim
To evaluate biological behavior of human peripheral mononuclear cells (PBMC) in contact with porous tantalum (PT) and Porphyromonas gingivalis (Pg).
Methods
Pg was incubated for 8 hours. The groups formed were: PBMC (control), PBMC + PT, PBMC + Pg and PBMC + PT + Pg. Cell viability was evaluated using MTT assay. The morphology and adhesion of PBMC to PT was evaluated using scanning electron microscopy. Expression of interleukin (IL)-10, transforming growth factor (TGF)-β, matrix metallopeptidase (MMP)-9 and receptor activator of nuclear factor-κΒ ligand (RANKL) was determined by enzyme-linked immunosorbent assay.
Results
MTT assay revealed that PT did not interfere in the mitochondrial activity of PBMC (P >.05). Scanning electron microscopy showed the adherence of PBMC to PT. IL-10 levels in PBMC + PT were similar to PBMC and lower than PBMC + Pg. TGF-β levels in PBMC + PT were higher than PBMC and PBMC + Pg. MMP-9 levels in PBMC + PT were similar to PBMC and lower than PBMC + Pg and PBMC + PT + Pg. RANKL levels in PBMC + PT were lower than in PBMC.
Conclusion
PT did not affect PBMC viability, allowed cell adhesion, reduced expression of RANKL and enhanced TGF-β in comparison with the control group.
{"title":"Effect of porous tantalum on the biological response of human peripheral mononuclear cells exposed to Porphyromonas gingivalis","authors":"Eduardo Frois Temponi, Paulo Eduardo Alencar Souza, Giovanna Ribeiro Souto, Luísa Mourão Dias Magalhães, Walderez Ornelas Dutra, Kenneth John Gollob, Tarcília Aparecida Silva, Rodrigo Villamarim Soares","doi":"10.1111/jicd.12472","DOIUrl":"10.1111/jicd.12472","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Aim</h3>\u0000 \u0000 <p>To evaluate biological behavior of human peripheral mononuclear cells (PBMC) in contact with porous tantalum (PT) and <i>Porphyromonas gingivalis</i> (<i>Pg</i>).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p><i>Pg</i> was incubated for 8 hours. The groups formed were: PBMC (control), PBMC + PT, PBMC + <i>Pg</i> and PBMC + PT + <i>Pg</i>. Cell viability was evaluated using MTT assay. The morphology and adhesion of PBMC to PT was evaluated using scanning electron microscopy. Expression of interleukin (IL)-10, transforming growth factor (TGF)-β, matrix metallopeptidase (MMP)-9 and receptor activator of nuclear factor-κΒ ligand (RANKL) was determined by enzyme-linked immunosorbent assay.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>MTT assay revealed that PT did not interfere in the mitochondrial activity of PBMC (<i>P </i>><i> </i>.05). Scanning electron microscopy showed the adherence of PBMC to PT. IL-10 levels in PBMC + PT were similar to PBMC and lower than PBMC + <i>Pg</i>. TGF-β levels in PBMC + PT were higher than PBMC and PBMC + <i>Pg</i>. MMP-9 levels in PBMC + PT were similar to PBMC and lower than PBMC + <i>Pg</i> and PBMC + PT + <i>Pg</i>. RANKL levels in PBMC + PT were lower than in PBMC.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>PT did not affect PBMC viability, allowed cell adhesion, reduced expression of RANKL and enhanced TGF-β in comparison with the control group.</p>\u0000 </section>\u0000 </div>","PeriodicalId":16204,"journal":{"name":"Journal of Investigative and Clinical Dentistry","volume":"10 4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-09-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1111/jicd.12472","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46607895","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Mariana D. Bellinaso, Fabio Z. M. Soares, Rachel de Olivera Rocha
The aim of the present study was to compare the restorative time for filling cavities in posterior teeth using bulk-fill and conventional resin composites through a systematic review and meta-analysis. A search for clinical trials and laboratory studies was performed in PubMed/MEDLINE, Scopus, the Latin American and Caribbean Health Sciences Literature database, the Brazilian Library in Dentistry, Cochrane Library, Clinical Trials, and ReBEC (Registro Brasileiro de Ensaios Clínicos) databases without publication year or language restriction. Two reviewers identified eligible studies according to the inclusion criteria: bulk-fill compared to conventional resin in class I or II, and the restorative time as an outcome. A meta-analysis of the restorative time mean difference between composites was performed (inverse variance method, random effects model; Z-test, P ≤ .05). From the 662 eligible studies, 133 were selected for full-text analysis; three were included in the systematic review and in the meta-analysis. Overall, the restorative time was lower when bulk-fill was used (P = .0007, Z = 3.37), as the subgroup full-body bulk-fill (P < .00001, Z = 21.00). There was no difference in restorative time between flowable bulk-fill and conventional resins (P = .08, Z = 1.76). Moderate-to-substantial heterogeneity was detected. Full-body bulk-fill composites decrease the restorative time in posterior teeth compared to conventional resins. Full-body bulk-fill resins require a shorter restorative time to perform restorations in posterior teeth than conventional resins, but the same is not valid for flowable bulk-fill resin composites.
本研究的目的是通过系统回顾和荟萃分析，比较使用大块填充和传统树脂复合材料填充后牙龋齿的恢复时间。在PubMed/MEDLINE、Scopus、拉丁美洲和加勒比健康科学文献数据库、巴西牙科图书馆、Cochrane图书馆、临床试验和ReBEC（Registro Brasileiro de Ensaios Clínicos）数据库中搜索临床试验和实验室研究，无出版年份或语言限制。两名评审员根据纳入标准确定了符合条件的研究：与I类或II类传统树脂相比的散装填充，以及作为结果的恢复时间。对复合材料之间的恢复时间平均差进行荟萃分析（逆方差法，随机效应模型；Z检验，P≤.05）。从662项符合条件的研究中，选择133项进行全文分析；三项纳入系统综述和荟萃分析。总体而言，当使用散装填充物时，恢复时间较低（P=.0007，Z=3.37），作为全身散装填充物的亚组（P<.00001，Z=21.00）。可流动散装填充物和传统树脂之间的恢复时间没有差异（P=.08，Z=1.76）。检测到中等至显著的不均匀性。与传统树脂相比，全身大块填充复合材料减少了后牙的恢复时间。与传统树脂相比，全身散装填充树脂在后牙进行修复所需的修复时间更短，但这对可流动散装填充树脂复合材料无效。
{"title":"Do bulk-fill resins decrease the restorative time in posterior teeth? A systematic review and meta-analysis of in vitro studies","authors":"Mariana D. Bellinaso, Fabio Z. M. Soares, Rachel de Olivera Rocha","doi":"10.1111/jicd.12463","DOIUrl":"10.1111/jicd.12463","url":null,"abstract":"<p>The aim of the present study was to compare the restorative time for filling cavities in posterior teeth using bulk-fill and conventional resin composites through a systematic review and meta-analysis. A search for clinical trials and laboratory studies was performed in PubMed/MEDLINE, Scopus, the Latin American and Caribbean Health Sciences Literature database, the Brazilian Library in Dentistry, Cochrane Library, Clinical Trials, and ReBEC (Registro Brasileiro de Ensaios Clínicos) databases without publication year or language restriction. Two reviewers identified eligible studies according to the inclusion criteria: bulk-fill compared to conventional resin in class I or II, and the restorative time as an outcome. A meta-analysis of the restorative time mean difference between composites was performed (inverse variance method, random effects model; Z-test, <i>P</i> ≤ .05). From the 662 eligible studies, 133 were selected for full-text analysis; three were included in the systematic review and in the meta-analysis. Overall, the restorative time was lower when bulk-fill was used (<i>P</i> = .0007, Z = 3.37), as the subgroup full-body bulk-fill (<i>P</i> < .00001, Z = 21.00). There was no difference in restorative time between flowable bulk-fill and conventional resins (<i>P</i> = .08, Z = 1.76). Moderate-to-substantial heterogeneity was detected. Full-body bulk-fill composites decrease the restorative time in posterior teeth compared to conventional resins. Full-body bulk-fill resins require a shorter restorative time to perform restorations in posterior teeth than conventional resins, but the same is not valid for flowable bulk-fill resin composites.</p>","PeriodicalId":16204,"journal":{"name":"Journal of Investigative and Clinical Dentistry","volume":"10 4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-09-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1111/jicd.12463","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43660208","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Physical properties of obturating materials have a direct effect on the quality of obturation; less viscous material will tend to extrude beyond the apex. We hypothesize that the use of absorbable gelatin sponge (AGS) can prevent the extrusion of these materials. This study aimed to evaluate the quality of obturation in root canals filled with iodoform-calcium hydroxide (Metapex) premixed paste and Metapex with AGS (MAGS) in primary molars.
Methods
This in vivo study comprised 60 primary mandibular molars which after instrumentation were divided into 2 groups according to the obturation material used, Metapex and MAGS, followed by radiographic evaluation to assess the quality of the obturation. The χ2-test was applied for statistical analysis.
Results
There was a statistically significant difference between Metapex and MAGS groups in achieving optimum obturation (P < .001). Metapex and MAGS exhibited 86.65% and 38.88% optimum obturation respectively. The overfilling of root canals effectively reduced from 38.88% to 4.44%.
Conclusion
The addition of AGS to Metapex causes a “tamponade effect”, which reduces the tendency of Metapex to extrude beyond the root apex. Root canal obturation using a modified filling paste like MAGS is effective in obtaining optimum obturation in primary teeth.
{"title":"Tamponade effect of resorbable biological barrier in quality of obturation in primary molar","authors":"Adesh Kakade, Heeresh Shetty, Anitha Santosh, Sayali Mali, Sheetal Badnaware, Bhagyashree Deshmukh, Karun Banthiya","doi":"10.1111/jicd.12468","DOIUrl":"10.1111/jicd.12468","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Aim</h3>\u0000 \u0000 <p>Physical properties of obturating materials have a direct effect on the quality of obturation; less viscous material will tend to extrude beyond the apex. We hypothesize that the use of absorbable gelatin sponge (AGS) can prevent the extrusion of these materials. This study aimed to evaluate the quality of obturation in root canals filled with iodoform-calcium hydroxide (Metapex) premixed paste and Metapex with AGS (MAGS) in primary molars.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>This in vivo study comprised 60 primary mandibular molars which after instrumentation were divided into 2 groups according to the obturation material used, Metapex and MAGS, followed by radiographic evaluation to assess the quality of the obturation. The χ<sup>2</sup>-test was applied for statistical analysis.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>There was a statistically significant difference between Metapex and MAGS groups in achieving optimum obturation (<i>P</i> < .001). Metapex and MAGS exhibited 86.65% and 38.88% optimum obturation respectively. The overfilling of root canals effectively reduced from 38.88% to 4.44%.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>The addition of AGS to Metapex causes a “tamponade effect”, which reduces the tendency of Metapex to extrude beyond the root apex. Root canal obturation using a modified filling paste like MAGS is effective in obtaining optimum obturation in primary teeth.</p>\u0000 </section>\u0000 </div>","PeriodicalId":16204,"journal":{"name":"Journal of Investigative and Clinical Dentistry","volume":"10 4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1111/jicd.12468","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43444530","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Thaís Yumi Umeda Suzuki, João Eduardo Gomes-Filho, André Luiz Fraga Briso, Wirley Gonçalves Assunção, Paulo Henrique dos Santos
Aim
The aim of the present study was to evaluate the pushout bond strength between glass-fiber posts to different regions of intraradicular dentin with different materials for adhesive cementation.
Methods
After endodontic filling, 40 teeth were divided into five groups according to adhesive cementation: Adper Single Bond 2 + RelyX ARC, Excite DSC + RelyX ARC (EXC), Adper SE Plus + RelyX ARC (SEP), RelyX Unicem, and Set. After the bonding process, roots were sectioned obtaining slices to be analyzed from each third. The bond strength was measured using the pushout test in a universal testing machine (Emic DL 3000) at a cross-head speed of .5 mm/minutes in different areas of the post space (cervical, middle, and apical). Data were subjected to analysis of variance and Fisher's test (α = .05).
Results
The highest values for the pushout bond strength were found for the SEP group in all experimental conditions, without a significant difference for the EXC group in the middle and apical regions. There was a decrease in pushout bond strength in the cervical-apical direction for all groups, except the EXC group, which did not show a difference among the different regions.
Conclusions
The different interactions of the resin materials and the intraradicular depth influenced the bond strength of adhesives materials to dentin substrate.
目的本研究的目的是评估不同材料的玻璃纤维桩与根内牙本质不同区域的粘结强度。方法根管充填后，将40颗牙齿按粘接方式分为5组：Adper Single Bond 2+RelyX ARC、Excite DSC+RelyX ARC（EXC）、Adper SE Plus+RelyX ARC（SEP）、RelyX Unicem和Set。在结合过程之后，对根部进行切片，从每三分之一处获得待分析的切片。使用通用试验机（Emic DL 3000）中的推出试验，以0.5 mm/分钟的十字头速度在桩间隙的不同区域（颈部、中部和心尖）测量结合强度。数据经过方差分析和Fisher检验（α=.05）。结果在所有实验条件下，SEP组的推出粘结强度最高，而EXC组在中部和心尖区域没有显著差异。除EXC组外，所有组的颈顶端方向的推出结合强度都有所下降，不同区域之间没有差异。结论树脂材料和根内深度的不同相互作用影响了粘接材料与牙本质基质的结合强度。
{"title":"Influence of the depth of intraradicular dentin on the pushout bond strength of resin materials","authors":"Thaís Yumi Umeda Suzuki, João Eduardo Gomes-Filho, André Luiz Fraga Briso, Wirley Gonçalves Assunção, Paulo Henrique dos Santos","doi":"10.1111/jicd.12461","DOIUrl":"10.1111/jicd.12461","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Aim</h3>\u0000 \u0000 <p>The aim of the present study was to evaluate the pushout bond strength between glass-fiber posts to different regions of intraradicular dentin with different materials for adhesive cementation.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>After endodontic filling, 40 teeth were divided into five groups according to adhesive cementation: Adper Single Bond 2 + RelyX ARC, Excite DSC + RelyX ARC (EXC), Adper SE Plus + RelyX ARC (SEP), RelyX Unicem, and Set. After the bonding process, roots were sectioned obtaining slices to be analyzed from each third. The bond strength was measured using the pushout test in a universal testing machine (Emic DL 3000) at a cross-head speed of .5 mm/minutes in different areas of the post space (cervical, middle, and apical). Data were subjected to analysis of variance and Fisher's test (α = .05).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>The highest values for the pushout bond strength were found for the SEP group in all experimental conditions, without a significant difference for the EXC group in the middle and apical regions. There was a decrease in pushout bond strength in the cervical-apical direction for all groups, except the EXC group, which did not show a difference among the different regions.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>The different interactions of the resin materials and the intraradicular depth influenced the bond strength of adhesives materials to dentin substrate.</p>\u0000 </section>\u0000 </div>","PeriodicalId":16204,"journal":{"name":"Journal of Investigative and Clinical Dentistry","volume":"10 4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1111/jicd.12461","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48406390","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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