Journal of Investigative and Clinical Dentistry最新文献

英文中文

Anti-apoptotic traits in gingival tissue from patients with severe generalized chronic periodontitis 重度全身性慢性牙周炎患者牙龈组织的抗凋亡特性

Q1 Medicine

Journal of Investigative and Clinical Dentistry

Pub Date : 2019-06-13 DOI: 10.1111/jicd.12422

Carlos Marcelo Figueredo, Juliana Cardoso Alves, Tatiane Flôr Coelho de Souza Breves Beiler, Ricardo Guimarães Fischer

Aim

In the present study, we aimed to evaluate the cytosolic and nuclear-mitochondrial expression of pro-apoptotic and anti-apoptotic markers in gingival tissue from patients with severe generalized chronic periodontitis (sGCP).

Methods

Twenty-four patients participated in the study: 15 (54.3 + 8.3 years) with sGCP and nine (38.2 + 5.4 years) with gingivitis alone. Gingival tissue was collected using a 1.5-mm diameter punch and homogenized using a cell disruptor. The supernatants were analyzed for the cytosolic and nuclear-mitochondrial fractions of caspase-3, Bax, Bak, Smac, lamin B, Bad, Bim, survivin, Bcl-xL, Mcl-1, and of the dimers Bcl-2/Bax, Bcl-xL/Bak and Mcl-1/Bak using a multiplex immunoassay.

Results

Significantly higher levels of cytosolic Bcl-xL/Bak, nuclear-mitochondrial Mcl-1/Bak, and cytosolic Bcl-xL were observed in gingival tissues from periodontitis patients compared to controls (P = 0.03, 0.03, and 0.05, respectively). The patients with gingivitis presented significantly increased levels of nuclear-mitochondrial Bad, cytosolic and nuclear-mitochondrial Bcl-2/Bax, and cytosolic Bim compared to the patients with periodontitis (P < 0.001, 0.03, 0.05, and 0.04, respectively).

Conclusion

Significantly higher levels of anti-apoptotic markers, such as Bcl-xL/Bak, Mcl-1/Bak, and Bcl-xL, and lower levels of pro-apoptotic markers Bad and Bim in inflamed tissues indicate an anti-apoptotic trait in patients with sGCP.

目的研究重度广泛性慢性牙周炎(sGCP)患者牙龈组织中促凋亡和抗凋亡标志物的胞浆和核线粒体表达。方法24例患者中，15例(54.3 + 8.3年)为sGCP, 9例(38.2 + 5.4年)为单纯牙龈炎。使用直径1.5 mm的穿孔器收集牙龈组织，并使用细胞干扰剂均匀化。利用多重免疫分析法分析上清液中caspase-3、Bax、Bak、Smac、lamin B、Bad、Bim、survivin、Bcl-xL、Mcl-1以及二聚体Bcl-2/Bax、Bcl-xL/Bak和Mcl-1/Bak的胞浆和核线粒体组分。结果牙周炎患者牙龈组织中胞浆Bcl-xL/Bak、核线粒体Mcl-1/Bak和胞浆Bcl-xL水平明显高于对照组(P值分别为0.03、0.03和0.05)。牙龈炎患者与牙周炎患者相比，核线粒体Bad、胞质和核线粒体Bcl-2/Bax、胞质Bim水平显著升高(P <0.001、0.03、0.05和0.04)。结论sGCP患者炎症组织中抗凋亡标志物Bcl-xL/Bak、Mcl-1/Bak、Bcl-xL水平升高，促凋亡标志物Bad、Bim水平降低，提示sGCP患者具有抗凋亡特征。

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引用次数: 4

Endodontically treated posterior teeth restored with or without crown restorations: A 5-year retrospective study of survival rates from fracture 根管治疗后牙有或没有冠修复:骨折存活率的5年回顾性研究

Q1 Medicine

Journal of Investigative and Clinical Dentistry

Pub Date : 2019-06-12 DOI: 10.1111/jicd.12426

Titalee Jirathanyanatt, Warattama Suksaphar, Danuchit Banomyong, Yaowaluk Ngoenwiwatkul

Aim

The aim of the present study was to investigate survival rates from fracture of endodontically treated posterior teeth (ETT) restored with or without crowns with recall periods of up to 5 years.

Methods

ETT with single-unit crown or resin composite restorations were studied based on the inclusion criteria. Restoration, tooth structure loss, adjacent teeth, fracture, and restorability were recorded. Survival rates from fracture were calculated, and risk factors were identified.

Results

Overall, survival rate of ETT with crowns (92.2%) was significantly higher than resin composites (77.4%) (P < 0.05). ETT with one or two surface loss/es and two adjacent teeth had a high survival rate of 86.9%, which was not significantly different to ETT with crowns (P ≥ 0.05). Restoration and adjacent teeth were identified as significant factors. The majority of fractured ETT with resin composites were restorable, whereas those with crowns were unrestorable. Survival rates from unrestorable fracture were not significantly different between the crown (93.1%) and resin composite (96%) (P ≥ 0.05).

Conclusions

The survival rate from the fracture of ETT restored with crowns was significantly higher than ETT restored with resin composites, but was not significantly different to ETT with one or two ETT with one or two surface loss/es and two adjacent teeth. ETT restored with resin composites had mostly restorable fracture, whereas ETT with unrestorable fracture were similar between the two restorations.

目的本研究的目的是调查有冠或无冠后牙根管治疗后牙(ETT)骨折的存活率，回忆期长达5年。方法根据纳入标准对单冠和树脂复合修复体进行研究。记录修复、牙齿结构损失、邻近牙齿、骨折和可修复性。计算骨折的存活率，并确定危险因素。结果整体而言，ETT带冠成活率(92.2%)显著高于树脂复合成活率(77.4%)(P <0.05)。1个或2个表面损失/es和相邻2颗牙的ETT成活率为86.9%，与有冠的ETT成活率差异无统计学意义(P≥0.05)。修复体和邻近牙齿被认为是重要的因素。采用树脂复合材料的断裂ETT大部分是可修复的，而有冠的则是不可修复的。冠状体与复合树脂的骨折不可恢复性生存率差异无统计学意义(P≥0.05)。结论牙冠修复的全牙体骨折成活率明显高于树脂复合材料修复的全牙体，但与单牙或双牙表面缺损的全牙体及相邻两牙的全牙体无显著差异。树脂复合材料修复的ETT骨折多为可恢复性骨折，而两种修复的ETT骨折不可恢复性骨折相似。

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引用次数: 12

Multiplex polymerase chain reaction for detection of bacteremia during dental extraction 多重聚合酶链反应检测拔牙过程中的菌血症

Q1 Medicine

Journal of Investigative and Clinical Dentistry

Pub Date : 2019-06-07 DOI: 10.1111/jicd.12425

Azita Azad, Farzan Modaresi, Maryam Zahed, Mahshid Zarei, Alireza Ranjbaran, Zahra Kargar Jahrom

Aim

Incidence of transient bacteremia following dental extractions ranges 30%-70% among adults and 58%-100% in children. This study aims to assess the multiplex polymerase chain reaction (PCR) technique in detection of transient bacteremia during dental extraction.

Methods

Twenty volunteers for dental extraction entered the study. Blood samples were taken at baseline and 30 seconds and 15 minutes after extraction. Five types of bacteria were selected, namely Streptococcus mutans, S. salivarius, S. sanguinis, Enterococcus faecalis and Lactobacillus. Blood samples were evaluated by microbial culture and multiplex PCR.

Results

Blood culture showed rates of 0%, 80% and 25% for bacteremia before, during and after dental extraction, respectively. A significant difference was observed between baseline and during extraction. Using PCR, bacteremia was deemed 20%, 100% and 30% before, during and after extraction, respectively, and a significant difference was witnessed between the baseline and during extraction. The highest incidence was at the 30-second mark after extraction, and the most prevalent type of bacteria was S. mutans.

Conclusions

Multiplex PCR can be used to determine bacterial diversity with high accuracy during occurrence of bacteremia. Therefore, in cases where positive blood cultures only indicate the presence of one species, we recommend the use of this method to detect more diverse bacteria types.

目的成人拔牙后短暂菌血症的发生率为30% ~ 70%，儿童为58% ~ 100%。本研究旨在探讨多重聚合酶链反应(PCR)技术在拔牙过程中短暂菌血症检测中的应用。方法20名拔牙志愿者加入研究。分别在基线、提取后30秒和15分钟采集血样。选取变形链球菌、唾液链球菌、血链球菌、粪肠球菌和乳杆菌5种细菌。血样采用微生物培养和多重PCR检测。结果拔牙前、拔牙中、拔牙后血培养菌血症率分别为0%、80%、25%。在基线和拔牙期间观察到显著差异。采用PCR方法，提取前、提取中、提取后菌血症分别为20%、100%、30%，基线值与提取时差异显著。在提取后30秒发生率最高，最常见的细菌类型是S. mutans。结论多重聚合酶链反应(PCR)可准确测定菌血症发生时的细菌多样性。因此，在阳性血培养只表明一种细菌存在的情况下，我们建议使用这种方法来检测更多样化的细菌类型。

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引用次数: 1

Effect of non-surgical periodontal treatment on gingival crevicular fluid and serum leptin levels in periodontally healthy chronic periodontitis and chronic periodontitis patients with type 2 diabetes mellitus 牙周非手术治疗对牙周健康慢性牙周炎和慢性牙周炎合并2型糖尿病患者龈沟液及血清瘦素水平的影响

Q1 Medicine

Journal of Investigative and Clinical Dentistry

Pub Date : 2019-06-06 DOI: 10.1111/jicd.12420

Charu R. Ahuja, Abhay P. Kolte, Rajashri A. Kolte, Madhur Gupta, Suresh Chari

Aim

The aim of the present study was to evaluate the effect of non-surgical periodontal therapy (NSPT) on gingival crevicular fluid (GCF) and serum leptin levels and glycemic status in periodontally healthy patients with chronic periodontitis (CP) with and without type 2 diabetes mellitus (T2DM).

Methods

Ninety patients were divided into three groups: periodontally healthy (group 1), CP (group 2) and CP with T2DM (group 3). The groups were evaluated for clinical parameters of probing pocket depth (PPD), clinical attachment level (CAL), plaque index, gingival index, biochemical parameters of GCF, serum leptin levels, and glycemic status pre- and post-NSPT.

Results

The baseline PPD and CAL for group 2 was 4.98 ± 0.49 mm and 5.35 ± 0.55 mm, respectively; for group 3 it was 5.60 ± 0.38 mm and 6.01 ± 0.38 mm, respectively. There was a considerable reduction in these parameters post-NSPT, with group 2 showing better resolution. Pretreatment serum leptin levels revealed increasing values from group 1 to group 3 and decreasing GCF values from group 3 to group 1, exhibiting an inverse relationship. Group 3 also showed an improvement in glycemic status post-NSPT.

Conclusion

NSPT was effective in improving clinical parameters, increasing GCF, reducing serum leptin levels, and also improving glycemic status in patients with CP and CP with T2DM.

目的探讨非手术牙周治疗(NSPT)对伴有和不伴有2型糖尿病(T2DM)的慢性牙周炎(CP)患者龈沟液(GCF)、血清瘦素水平及血糖水平的影响。方法将90例患者分为牙周健康组(1组)、CP组(2组)和CP合并T2DM组(3组)，对各组患者进行探查袋深度(PPD)、临床附着水平(CAL)、菌斑指数、牙龈指数、GCF生化指标、血清瘦素水平、nspt前后血糖状态等临床指标的评估。结果2组基线PPD和CAL分别为4.98±0.49 mm和5.35±0.55 mm;3组分别为5.60±0.38 mm和6.01±0.38 mm。nspt后这些参数有相当大的降低，2组表现出更好的分辨率。预处理后血清瘦素水平从1组升高到3组，GCF值从3组降低到1组，呈反比关系。第三组在nspt后血糖状况也有所改善。结论NSPT可改善CP及CP合并T2DM患者的临床参数，提高GCF，降低血清瘦素水平，改善血糖状态。

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引用次数: 9

Electronic and paper mode of data capture when assessing patient-reported outcomes in the National Dental Practice-Based Research Network 在国家牙科实践为基础的研究网络评估患者报告的结果时，电子和纸张模式的数据捕获

Q1 Medicine

Journal of Investigative and Clinical Dentistry

Pub Date : 2019-06-02 DOI: 10.1111/jicd.12427

Dorota T. Kopycka-Kedzierawski, Rita Cacciato, Roslyn Hennessey, Cyril Meyerowitz, Mark S. Litaker, Marc W. Heft, Kimberly S. Johnson, Stephanie C. Reyes, James D. Johnson, Camille T. Baltuck, Gregg H. Gilbert, National Dental PBRN Collaborative Group

Aim

Our objectives were to describe the approach used in the National Dental Practice-Based Research Network to capture patient-reported outcomes and to compare electronic and paper modes of data capture in a specific network study.

Methods

This was a prospective, multicenter cohort study of 1862 patients with dentin hypersensitivity. Patient-reported outcomes were assessed based on patients’ perception of pain using Visual Analog Scales and Labeled Magnitude scales at baseline and at 1, 4 and 8 weeks post-baseline.

Results

Eighty-five percent of study patients chose to complete follow-up assessments via an electronic mode; 15% completed them via a paper mode. There was not a significant difference in the proportions of patients who completed the 8-week assessment when comparing the electronic mode to the paper mode (92% vs. 90.8%, P = 0.31, Rao-Scott clustered χ²-test).

Conclusion

The electronic mode of data capture was as operational as the traditional paper mode, while also providing the advantage of eliminating data entry errors, not involving site research coordinators in measuring the patient-reported outcomes, and not incurring cost and potential delays due to mailing study forms. Electronic data capture of patient reported outcomes could be successfully implemented in the community dental practice setting.

我们的目的是描述国家牙科实践研究网络中用于获取患者报告结果的方法，并在特定网络研究中比较电子和纸质数据获取模式。方法对1862例牙本质过敏患者进行前瞻性、多中心队列研究。患者报告的结果是基于患者在基线和基线后1、4和8周使用视觉模拟量表和标记数量级量表对疼痛的感知进行评估。结果85%的研究患者选择通过电子模式完成随访评估;15%的人通过书面方式完成。电子模式与纸质模式比较，完成8周评估的患者比例差异无统计学意义(92% vs. 90.8%， P = 0.31, Rao-Scott聚类χ2检验)。结论电子数据采集模式与传统纸质数据采集模式具有相同的可操作性，同时也具有消除数据输入错误、不涉及现场研究协调员测量患者报告结果、避免因邮寄研究表格而产生成本和潜在延迟的优点。患者报告结果的电子数据捕获可以成功地实施在社区牙科诊所设置。

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引用次数: 1

Future of periodontics lies in artificial intelligence: Myth or reality? 牙周病的未来在于人工智能:神话还是现实?

Q1 Medicine

Journal of Investigative and Clinical Dentistry

Pub Date : 2019-05-23 DOI: 10.1111/jicd.12423

Manchala S. Reddy, Shishir R. Shetty, Raghavendra M. Shetty, Venkataramana Vannala, Shakeel Sk

引用次数: 4

Secondary dentition characteristics in an ethnic Chinese orthodontic population: A retrospective cross-sectional study 中华民族正畸人群的次牙列特征:一项回顾性横断面研究

Q1 Medicine

Journal of Investigative and Clinical Dentistry

Pub Date : 2019-05-15 DOI: 10.1111/jicd.12421

Grace X. L. Chan, Elaine L. Y. Tan, Ming T. Chew, Hung C. Wong, Kelvin W. C. Foong, Mimi Yow

Aim

To determine the prevalence of dental anomalies and its association with gender.

Methods

This retrospective cross-sectional study was conducted using radiographs, photographs and clinical records of patients who attended the Department of Orthodontics at the National Dental Centre Singapore. Records of 2508 ethnic Chinese orthodontic patients aged 14-25 years were examined for the prevalence of dental anomalies in the permanent dentition, excluding third molars. Statistical analyses were performed using SAS version 9.4 (SAS Institute Inc.). Logistic regression was used to determine the association between gender and the occurrence of various dental anomalies. Kappa coefficients were calculated to test for intra-examiner reproducibility. Statistical significance was set at P < 0.05.

Results

Prevalence of dental anomalies was 5.7% hyperdontia, 11.1% hypodontia, 5.5% peg-shaped upper lateral incisors, 21.9% impacted teeth, 1.3% transposition and 0.4% double teeth. There was no significant gender difference in the occurrence of the anomalies except hyperdontia, with males having significantly higher odds of hyperdontia compared with females (odds ratio, 1.488; 95% confidence interval, 1.062-2.085; P = 0.021).

Conclusion

Occurrence of hyperdontia is greater in males than females, while no significant gender differences were noted for hypodontia, peg-shaped upper lateral incisors, impacted teeth, transposition and double teeth.

目的探讨口腔畸形的发生率及其与性别的关系。方法回顾性分析了在新加坡国立牙科中心正畸科就诊的患者的x线片、照片和临床记录。对2508例14 ~ 25岁汉族正畸患者的恒牙(除第三磨牙外)牙畸形的发生率进行了调查。采用SAS 9.4版(SAS Institute Inc.)进行统计分析。采用Logistic回归来确定性别与各种牙齿异常发生之间的关系。计算Kappa系数以检验审查员内部的再现性。P <有统计学意义;0.05. 结果牙畸形发生率为:牙多畸形5.7%，牙下畸形11.1%，上侧门牙钉形5.5%，阻生牙21.9%，转位1.3%，双牙0.4%。除多牙症外，其他畸形的发生性别差异不显著，男性多牙症的发生率明显高于女性(优势比为1.488;95%置信区间为1.062 ~ 2.085;p = 0.021)。结论男性多牙症发生率高于女性，而下颌多牙症、桩状上侧切牙、阻生牙、转位、双牙的性别差异不显著。

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引用次数: 4

Could dental school teaching clinics provide better care than regular private practices? 牙科学校的教学诊所能提供比普通私人诊所更好的护理吗?

Q1 Medicine

Journal of Investigative and Clinical Dentistry

Pub Date : 2019-05-13 DOI: 10.1111/jicd.12329

Romesh P. Nalliah

Dental school clinics (DSC) consist of unlicensed dental students delivering care under the supervision of licensed dental professionals. Care delivery is slow due to inexperience of the provider and the series of supervisory checks that are necessary. Cost of care to the patient is less. To date, there has been no evaluation of the benefits of receiving care in a DSC beyond reduced fees. Research has shown the value of teaching hospitals in medicine, and the purpose of this article was to evaluate the total sum of benefits (the value proposition) of receiving dental care in a DSC.

牙科学校诊所(DSC)由无牌牙科学生组成，在持牌牙科专业人员的监督下提供护理。由于提供者缺乏经验和一系列必要的监督检查，护理交付缓慢。病人的护理费用更少。迄今为止，除了降低费用外，还没有对在DSC接受护理的好处进行评估。研究表明了教学医院在医学上的价值，本文的目的是评估在DSC中接受牙科护理的总收益(价值主张)。

引用次数: 1

Periodontal diagnosis, treatment, and referral patterns of general dental practitioners 牙周诊断、治疗和转诊模式的一般牙科医生

Q1 Medicine

Journal of Investigative and Clinical Dentistry

Pub Date : 2019-04-21 DOI: 10.1111/jicd.12411

Jennifer Kraatz, Ha Hoang, Saso Ivanovski, Robert S. Ware, Leonard A. Crocombe

Aim

The aim of the present study was to investigate the diagnosis, treatment, and referral patterns of periodontal patients by general dental practitioners (GDP).

Methods

A questionnaire was mailed to registered GDP with publicly-listed postal addresses in Tasmania, Australia. Information was collected on demographics, training and professional development, examination, diagnosis and referral patterns, and periodontal treatment patterns.

Results

Seventy-seven (44.5%) questionnaires were completed. Over 85% always or usually screened for periodontal disease. On average, 0 to ≤7 patients were diagnosed with periodontal disease. GDP were always or usually confident in treating gingivitis (100%), mild (98.7%) and moderate periodontitis (73.7%), and rarely or never confident in treating severe (81.6%) and aggressive periodontitis (86.8%). Over 38% frequently referred to periodontists, 35.5% sometimes, 21.1% rarely, and 5.3% never. Clinical factors associated with referral were periodontal pocketing of ≥6 mm, tooth mobility, no improvement following treatment, and a complex medical history.

Conclusions

Most GDP performed periodontal screening and diagnosis. They were confident in treating gingivitis and mild-to-moderate periodontitis. Referral to a periodontist was associated with disease severity, tooth mobility, a complex medical history, or unsuccessful treatment.

目的本研究的目的是调查普通牙科医生(GDP)对牙周病患者的诊断、治疗和转诊模式。方法将问卷邮寄至澳大利亚塔斯马尼亚州注册GDP单位。收集了人口统计、培训和专业发展、检查、诊断和转诊模式以及牙周治疗模式等方面的信息。结果共完成问卷77份(44.5%)。超过85%的人经常或经常接受牙周病筛查。平均0 ~≤7例患者被诊断为牙周病。GDP对牙龈炎(100%)、轻度(98.7%)和中度牙周炎(73.7%)一直或通常有信心，对重度(81.6%)和侵袭性牙周炎(86.8%)很少或从不有信心。超过38%的患者经常就诊，35.5%有时就诊，21.1%很少就诊，5.3%从不就诊。与转诊相关的临床因素是牙周袋≥6 mm，牙齿活动，治疗后无改善，以及复杂的病史。结论大多数GDP进行牙周筛查和诊断。他们对治疗牙龈炎和轻中度牙周炎很有信心。转诊到牙周病医生与疾病严重程度、牙齿活动度、复杂病史或治疗不成功有关。

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引用次数: 7

Cytogenetic biomonitoring in buccal mucosa cells after exposure to mouth rinses: Is it possible? 口腔黏膜细胞暴露于漱口水后的细胞遗传学生物监测:可能吗?

Q1 Medicine

Journal of Investigative and Clinical Dentistry

Pub Date : 2019-04-19 DOI: 10.1111/jicd.12419

Daniel A. Ribeiro

引用次数: 0

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