Pub Date : 2021-01-01DOI: 10.5352/JLS.2021.31.1.52
Young Sun Lee, Gyoung-Hee Kim, J. Jung
{"title":"Distribution of Subgroups in Pseudomonas syringae pv. actinidiae Biovar 3 Strains Isolated from Korea","authors":"Young Sun Lee, Gyoung-Hee Kim, J. Jung","doi":"10.5352/JLS.2021.31.1.52","DOIUrl":"https://doi.org/10.5352/JLS.2021.31.1.52","url":null,"abstract":"","PeriodicalId":16322,"journal":{"name":"Journal of Life Science","volume":"17 1","pages":"52-58"},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88197772","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-01-01DOI: 10.5352/JLS.2021.31.2.158
Geun-Ho Kim, Eunjoo Lee, S. Ryu, H. Sohn, Jongsik Kim
{"title":"Anti-inflammatory Activities of Apple Extracts and Phloretin","authors":"Geun-Ho Kim, Eunjoo Lee, S. Ryu, H. Sohn, Jongsik Kim","doi":"10.5352/JLS.2021.31.2.158","DOIUrl":"https://doi.org/10.5352/JLS.2021.31.2.158","url":null,"abstract":"","PeriodicalId":16322,"journal":{"name":"Journal of Life Science","volume":"47 1","pages":"158-163"},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74362053","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-01-01DOI: 10.5352/JLS.2021.31.2.126
D. H. Kim, Jeong Hwan Kim, Seh-Kwang Park, J. Jeong, Mi-young Kim, S. Nam, Hyesook Lee, Yung-Hyun Choi
1 Department of Smart Bio-Health, Dong-eui University, Busan 47340, Korea 2 Research and Development Department, BGN CARE Co., Ltd., Busan 47195, Korea 3 BGN Eye Clinic, Seoul 05551, Korea 4 BGN Eye Clinic, Busan 47195, Korea Department of Biotechnology, Dong-eui University, Busan 47340, Korea Anti-Aging Research Center, Dong-eui University, Busan 47340, Korea Department of Biochemistry, Dong-eui University College of Korean Medicine, Busan 47227, Korea
{"title":"Comparison of the Cytoprotective Effects of Several Natural and Synthetic Compounds against Oxidative Stress in Human Retinal Pigment Epithelial Cells","authors":"D. H. Kim, Jeong Hwan Kim, Seh-Kwang Park, J. Jeong, Mi-young Kim, S. Nam, Hyesook Lee, Yung-Hyun Choi","doi":"10.5352/JLS.2021.31.2.126","DOIUrl":"https://doi.org/10.5352/JLS.2021.31.2.126","url":null,"abstract":"1 Department of Smart Bio-Health, Dong-eui University, Busan 47340, Korea 2 Research and Development Department, BGN CARE Co., Ltd., Busan 47195, Korea 3 BGN Eye Clinic, Seoul 05551, Korea 4 BGN Eye Clinic, Busan 47195, Korea Department of Biotechnology, Dong-eui University, Busan 47340, Korea Anti-Aging Research Center, Dong-eui University, Busan 47340, Korea Department of Biochemistry, Dong-eui University College of Korean Medicine, Busan 47227, Korea","PeriodicalId":16322,"journal":{"name":"Journal of Life Science","volume":"94 1","pages":"126-136"},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91050691","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-01-01DOI: 10.5352/JLS.2021.31.2.192
G. Kwon, Byunghyuk Kim, Jun-Hyeong Lee, H. Hwang, Jung-Bok Lee
Red yeast rice has been extensively used as food and traditional medicine for thousands of years in East Asian countries. It is produced by the fermentation of a particular yeast (in general, Monascus purpureus) as rice and various cereals (barley, soybean, etc.). Monascus sp. produces many secondary metabolites during its growth, including pigments, monacolins, and γ-aminobutyric acid. Some metabolites—specifically, monacolin K, γ-aminobutyric acid, dimerumic acid, and monascus pigments—have been reported to lower cholesterol and blood pressure while showing anti-obesity effects. In this study, we investigated the anti-obesity effect of ethanol extract from red yeast barley (RYB) fermented with Monascus sp. BHN-MK 2 on 3T3-L1 cells. The anti-obesity effects of RYB extract were examined: its lipid accumulation inhibitory effect was tested by Oil Red O staining, and obesity-related mRNA expression levels were tested by real-time RT-PCR in MDI stimulated 3T3-L1 cells. The intracellular lipid content of MDI-stimulated 3T3-L1 cells decreased significantly to 5.04%, 12.24%, and 23.52% in response to 200, 400, and 800 μg/ml RYB, respectively. Moreovers, we evaluated that RYB extract significantly downregulated the expression of C/EBPα, SREBP-1, and PPAR-γ gene in a dose-dependent manner. As a result, red yeast barley ethanol extracts exerted the strongest anti-obesity effects. Also, the results indicate that red yeast barley could be used as a functional anti-obesity food material.
{"title":"Evaluation of Lipid Accumulation’s Inhibitory Activity on 3T3-L1 Cells with Red Yeast Barley Extracts","authors":"G. Kwon, Byunghyuk Kim, Jun-Hyeong Lee, H. Hwang, Jung-Bok Lee","doi":"10.5352/JLS.2021.31.2.192","DOIUrl":"https://doi.org/10.5352/JLS.2021.31.2.192","url":null,"abstract":"Red yeast rice has been extensively used as food and traditional medicine for thousands of years in East Asian countries. It is produced by the fermentation of a particular yeast (in general, Monascus purpureus) as rice and various cereals (barley, soybean, etc.). Monascus sp. produces many secondary metabolites during its growth, including pigments, monacolins, and γ-aminobutyric acid. Some metabolites—specifically, monacolin K, γ-aminobutyric acid, dimerumic acid, and monascus pigments—have been reported to lower cholesterol and blood pressure while showing anti-obesity effects. In this study, we investigated the anti-obesity effect of ethanol extract from red yeast barley (RYB) fermented with Monascus sp. BHN-MK 2 on 3T3-L1 cells. The anti-obesity effects of RYB extract were examined: its lipid accumulation inhibitory effect was tested by Oil Red O staining, and obesity-related mRNA expression levels were tested by real-time RT-PCR in MDI stimulated 3T3-L1 cells. The intracellular lipid content of MDI-stimulated 3T3-L1 cells decreased significantly to 5.04%, 12.24%, and 23.52% in response to 200, 400, and 800 μg/ml RYB, respectively. Moreovers, we evaluated that RYB extract significantly downregulated the expression of C/EBPα, SREBP-1, and PPAR-γ gene in a dose-dependent manner. As a result, red yeast barley ethanol extracts exerted the strongest anti-obesity effects. Also, the results indicate that red yeast barley could be used as a functional anti-obesity food material.","PeriodicalId":16322,"journal":{"name":"Journal of Life Science","volume":"14 1","pages":"192-198"},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91212920","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-01-01DOI: 10.5352/JLS.2021.31.2.248
Seo-Young Park, Yeong-Bin Baek, Sang-Ik Park, Chang-Min Lee, Sung-Hak Kim
{"title":"The Significance of Cancer Stem Cells in Canine Mammary Gland Tumors","authors":"Seo-Young Park, Yeong-Bin Baek, Sang-Ik Park, Chang-Min Lee, Sung-Hak Kim","doi":"10.5352/JLS.2021.31.2.248","DOIUrl":"https://doi.org/10.5352/JLS.2021.31.2.248","url":null,"abstract":"","PeriodicalId":16322,"journal":{"name":"Journal of Life Science","volume":"4 1","pages":"248-255"},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83678862","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-01-01DOI: 10.5352/JLS.2021.31.2.183
Sun Yu, B. Park, Ji Won Kim, You Lim Hwang, S. H. Kim, Sunah Kim, Lee Tae-Ho, AhnSoon Cheol
{"title":"Immunomodulatory Effects of Euglena gracilis Extracts","authors":"Sun Yu, B. Park, Ji Won Kim, You Lim Hwang, S. H. Kim, Sunah Kim, Lee Tae-Ho, AhnSoon Cheol","doi":"10.5352/JLS.2021.31.2.183","DOIUrl":"https://doi.org/10.5352/JLS.2021.31.2.183","url":null,"abstract":"","PeriodicalId":16322,"journal":{"name":"Journal of Life Science","volume":"25 1","pages":"183-191"},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73474645","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-01-01DOI: 10.5352/JLS.2021.31.1.73
Young-Soo Ryu, M. Heo
{"title":"Phylogenetic Diversity and Antibacterial Activity of Bacteria from Shindari of Jeju Traditional Fermented Food","authors":"Young-Soo Ryu, M. Heo","doi":"10.5352/JLS.2021.31.1.73","DOIUrl":"https://doi.org/10.5352/JLS.2021.31.1.73","url":null,"abstract":"","PeriodicalId":16322,"journal":{"name":"Journal of Life Science","volume":"1 1","pages":"73-82"},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83481036","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-01-01DOI: 10.5352/JLS.2020.30.6.532
J. Choi, J. Lim, Bo Ram Sim, Yung-Hun Yang
1 Department of Culinary Arts & Hotel Food Service-Major in Culinary Arts, Yeonsung University, Yanghwa-ro 37beon-gil 34, Manan-gu, Anyang-si, Gyeonggi-do 14011, Korea L.FOUNDER INC., 406, Business Incubation Seoul National University of Science & Technology 232, Gongneung-ro, Nowon-gu, Seoul 01811, Korea Department of Biological Engineering, College of Engineering, Konkuk University, Neuundong-ro 120, Gwangjin-gu, Seoul 05029, Korea
{"title":"Inhibitory Effect of Lactic Acid Bacteria-fermented Chrysanthemum indicum L. on Adipocyte Differentiation through Hedgehog Signaling","authors":"J. Choi, J. Lim, Bo Ram Sim, Yung-Hun Yang","doi":"10.5352/JLS.2020.30.6.532","DOIUrl":"https://doi.org/10.5352/JLS.2020.30.6.532","url":null,"abstract":"1 Department of Culinary Arts & Hotel Food Service-Major in Culinary Arts, Yeonsung University, Yanghwa-ro 37beon-gil 34, Manan-gu, Anyang-si, Gyeonggi-do 14011, Korea L.FOUNDER INC., 406, Business Incubation Seoul National University of Science & Technology 232, Gongneung-ro, Nowon-gu, Seoul 01811, Korea Department of Biological Engineering, College of Engineering, Konkuk University, Neuundong-ro 120, Gwangjin-gu, Seoul 05029, Korea","PeriodicalId":16322,"journal":{"name":"Journal of Life Science","volume":"4 1","pages":"532-541"},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74618873","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-01-01DOI: 10.5352/JLS.2020.30.5.420
Ji-Young Park, H. Choi, Hyejin Lee, J. Ahn
{"title":"Improvement of Artificial Antibody Secretion Using Supercharged Protein","authors":"Ji-Young Park, H. Choi, Hyejin Lee, J. Ahn","doi":"10.5352/JLS.2020.30.5.420","DOIUrl":"https://doi.org/10.5352/JLS.2020.30.5.420","url":null,"abstract":"","PeriodicalId":16322,"journal":{"name":"Journal of Life Science","volume":"3 1","pages":"420-427"},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80526347","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-01-01DOI: 10.5352/JLS.2020.30.3.250
Won-Kyung Yang, Jong Kuk Kim, K. Park, S. Suh, Hye-Jeong Lee, M. Park
Diabetes is a well-known risk factor for dementia and cognitive impairment. Diabetic polyneuropathy (DPN) is the most prevalent microvascular complication in type 2 diabetes mellitus (T2DM) patients. The purpose of this study was to evaluate the relation between diabetic peripheral polyneuropathy and cognitive factors in T2DM patients. Retrospective chart review of type 2 diabetic patients with results of a nerve conduction study (NCS) and a neurocognitive study. A total of 19 patients were included. DPN was defined using data from a nerve conduction study: a score of less than 24 in the Korean version of the Mini-Mental State Examination (K-MMSE) was considered as an indicator of cognitive impairment (CI). The mean age of the 19 patients was 71.6±5.0 years. The mean duration of diabetes was 8.4±9.1 years, and the mean HbA1c level was 8.1±1.8%. DPN was present in 7 of the 19 patients. Based on the K-MMSE score, CI was diagnosed in eight patients. The mean K-MMSE scores and the prevalence of CI was not different between the groups with and without DPN. There was no significant difference in DPN prevalence between the groups with and without CI. Education was significantly correlated with cognitive factors. Only the digit span-forward among the cognitive factors showed a significant negative correlation with nerve conduction velocity. In conclusion, the longer education period was associated with higher cognitive function and no significant correlation was observed between diabetic peripheral neuropathy and cognitive dysfunction in type 2 diabetic patients. Further prospective research is needed in the future.
{"title":"Correlation between Peripheral Neuropathy and Cognitive Factors in Type 2 Diabetic Patients","authors":"Won-Kyung Yang, Jong Kuk Kim, K. Park, S. Suh, Hye-Jeong Lee, M. Park","doi":"10.5352/JLS.2020.30.3.250","DOIUrl":"https://doi.org/10.5352/JLS.2020.30.3.250","url":null,"abstract":"Diabetes is a well-known risk factor for dementia and cognitive impairment. Diabetic polyneuropathy (DPN) is the most prevalent microvascular complication in type 2 diabetes mellitus (T2DM) patients. The purpose of this study was to evaluate the relation between diabetic peripheral polyneuropathy and cognitive factors in T2DM patients. Retrospective chart review of type 2 diabetic patients with results of a nerve conduction study (NCS) and a neurocognitive study. A total of 19 patients were included. DPN was defined using data from a nerve conduction study: a score of less than 24 in the Korean version of the Mini-Mental State Examination (K-MMSE) was considered as an indicator of cognitive impairment (CI). The mean age of the 19 patients was 71.6±5.0 years. The mean duration of diabetes was 8.4±9.1 years, and the mean HbA1c level was 8.1±1.8%. DPN was present in 7 of the 19 patients. Based on the K-MMSE score, CI was diagnosed in eight patients. The mean K-MMSE scores and the prevalence of CI was not different between the groups with and without DPN. There was no significant difference in DPN prevalence between the groups with and without CI. Education was significantly correlated with cognitive factors. Only the digit span-forward among the cognitive factors showed a significant negative correlation with nerve conduction velocity. In conclusion, the longer education period was associated with higher cognitive function and no significant correlation was observed between diabetic peripheral neuropathy and cognitive dysfunction in type 2 diabetic patients. Further prospective research is needed in the future.","PeriodicalId":16322,"journal":{"name":"Journal of Life Science","volume":"38 1","pages":"250-259"},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90781640","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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