首页 > 最新文献

Journal of Microscopy and Ultrastructure最新文献

英文 中文
Pioglitazone Induces Dysplastic Urothelial Changes in Urinary Bladder of Experimental Diabetes. 吡格列酮诱导实验性糖尿病患者膀胱尿路上皮发育不良。
Q3 Medicine Pub Date : 2023-01-01 DOI: 10.4103/jmau.jmau_34_21
Ahmed A M Abdel-Hamid, Alaa El-Din L Firgany

Objectives: Pioglitazone (PIO) is a widely prescribed oral antidiabetic drug that has concerns regarding a potential risk of developing carcinoma of the urinary bladder. The objective of the current study was to assess this potential risk.

Materials and methods: The potential risk of PIO-induced urinary bladder carcinoma was assessed in the current study by examining urinary bladder of rats for urothelial cytokeratin (CK) expression and proliferative activity by Ki67 immunostaining.

Results: Histological examination revealed dysplastic urothelial changes in PIO per se and diabetes mellitus + PIO (diabetic rats receiving PIO). In addition, a significantly (P < 0.05) decreased CK7 and CK8 expression together with a significantly increased CK20 as well as Ki67 expression was detected in the urothelial cells of groups administrated PIO, contrary to those which did not.

Conclusion: The manifestations of urothelial dysplasia evidenced by histological examination as well as by the aberrant expression in CK and Ki67 after PIO administration add supporting evidence at cellular and experimental level to the previous clinical suspicions.

目的:吡格列酮(PIO)是一种广泛使用的口服降糖药,但有潜在的膀胱癌风险。本研究的目的是评估这种潜在风险。材料和方法:本研究通过Ki67免疫染色法检测大鼠膀胱尿路上皮细胞角蛋白(CK)表达和增殖活性,评估pio诱导膀胱癌的潜在风险。结果:组织学检查显示PIO本身和糖尿病+ PIO(接受PIO的糖尿病大鼠)的尿路上皮发育异常。此外,与未给药组相比,给药组尿路上皮细胞CK7和CK8表达显著(P < 0.05)降低,CK20和Ki67表达显著升高。结论:尿路上皮异常增生的组织学表现以及PIO后CK和Ki67的异常表达,为以往的临床怀疑提供了细胞和实验水平的支持证据。
{"title":"Pioglitazone Induces Dysplastic Urothelial Changes in Urinary Bladder of Experimental Diabetes.","authors":"Ahmed A M Abdel-Hamid,&nbsp;Alaa El-Din L Firgany","doi":"10.4103/jmau.jmau_34_21","DOIUrl":"https://doi.org/10.4103/jmau.jmau_34_21","url":null,"abstract":"<p><strong>Objectives: </strong>Pioglitazone (PIO) is a widely prescribed oral antidiabetic drug that has concerns regarding a potential risk of developing carcinoma of the urinary bladder. The objective of the current study was to assess this potential risk.</p><p><strong>Materials and methods: </strong>The potential risk of PIO-induced urinary bladder carcinoma was assessed in the current study by examining urinary bladder of rats for urothelial cytokeratin (CK) expression and proliferative activity by Ki67 immunostaining.</p><p><strong>Results: </strong>Histological examination revealed dysplastic urothelial changes in PIO <i>per se</i> and diabetes mellitus + PIO (diabetic rats receiving PIO). In addition, a significantly (<i>P</i> < 0.05) decreased CK7 and CK8 expression together with a significantly increased CK20 as well as Ki67 expression was detected in the urothelial cells of groups administrated PIO, contrary to those which did not.</p><p><strong>Conclusion: </strong>The manifestations of urothelial dysplasia evidenced by histological examination as well as by the aberrant expression in CK and Ki67 after PIO administration add supporting evidence at cellular and experimental level to the previous clinical suspicions.</p>","PeriodicalId":16340,"journal":{"name":"Journal of Microscopy and Ultrastructure","volume":"11 1","pages":"34-40"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/62/c5/JMAU-11-34.PMC10153741.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9415554","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Seasonal changes in the localization of cytokeratin AE1, alpha-smooth muscle actin, and S100 proteins in the testis and epididymis of the African Fruit Bat (Epomops franqueti 非洲果蝠睾丸和附睾细胞角蛋白AE1、α -平滑肌肌动蛋白和S100蛋白定位的季节变化
Q3 Medicine Pub Date : 2023-01-01 DOI: 10.4103/jmau.jmau_121_22
O. Ekeolu, S. Olukole, B. Oke
{"title":"Seasonal changes in the localization of cytokeratin AE1, alpha-smooth muscle actin, and S100 proteins in the testis and epididymis of the African Fruit Bat (Epomops franqueti","authors":"O. Ekeolu, S. Olukole, B. Oke","doi":"10.4103/jmau.jmau_121_22","DOIUrl":"https://doi.org/10.4103/jmau.jmau_121_22","url":null,"abstract":"","PeriodicalId":16340,"journal":{"name":"Journal of Microscopy and Ultrastructure","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70800243","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Evaluation of antimicrobial efficacy and osteogenic potential of titanium coated with hydrogel of Calendula officinalis: An in Vitro Study 金盏菊水凝胶包覆钛的体外抗菌效果及成骨潜力评价
Q3 Medicine Pub Date : 2023-01-01 DOI: 10.4103/jmau.jmau_22_23
P. Sardesai, Ramesh P. Nayakar, Ritiha Uppin, Sayed M. Killedar, K. Sutar, Anandkumar G. Patil
{"title":"Evaluation of antimicrobial efficacy and osteogenic potential of titanium coated with hydrogel of Calendula officinalis: An in Vitro Study","authors":"P. Sardesai, Ramesh P. Nayakar, Ritiha Uppin, Sayed M. Killedar, K. Sutar, Anandkumar G. Patil","doi":"10.4103/jmau.jmau_22_23","DOIUrl":"https://doi.org/10.4103/jmau.jmau_22_23","url":null,"abstract":"","PeriodicalId":16340,"journal":{"name":"Journal of Microscopy and Ultrastructure","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70800574","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Utility of hematological and biochemical parameters as a screening tool for assessing coronavirus disease 2019 infection and its severity 血液学和生化参数作为评估2019冠状病毒病感染及其严重程度的筛选工具的应用
Q3 Medicine Pub Date : 2023-01-01 DOI: 10.4103/jmau.jmau_59_22
Sabina Khan, Sana Alam, V. Jain, Varun Kashyap, P. Kapur
{"title":"Utility of hematological and biochemical parameters as a screening tool for assessing coronavirus disease 2019 infection and its severity","authors":"Sabina Khan, Sana Alam, V. Jain, Varun Kashyap, P. Kapur","doi":"10.4103/jmau.jmau_59_22","DOIUrl":"https://doi.org/10.4103/jmau.jmau_59_22","url":null,"abstract":"","PeriodicalId":16340,"journal":{"name":"Journal of Microscopy and Ultrastructure","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70801191","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Histological assessment of systemic toxicity induced by zinc oxide nanoparticles and the prophylactic potency of ascorbate in albino rats 氧化锌纳米颗粒对白化大鼠全身毒性的组织学评价及抗坏血酸的预防作用
Q3 Medicine Pub Date : 2023-01-01 DOI: 10.4103/jmau.jmau_68_22
Amira R. Osman, Said M. Afify, Amira Frag, S. Alghandour
{"title":"Histological assessment of systemic toxicity induced by zinc oxide nanoparticles and the prophylactic potency of ascorbate in albino rats","authors":"Amira R. Osman, Said M. Afify, Amira Frag, S. Alghandour","doi":"10.4103/jmau.jmau_68_22","DOIUrl":"https://doi.org/10.4103/jmau.jmau_68_22","url":null,"abstract":"","PeriodicalId":16340,"journal":{"name":"Journal of Microscopy and Ultrastructure","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70801603","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Pleomorphic adenoma in an immunocompromised patient 免疫功能低下患者的多形性腺瘤
Q3 Medicine Pub Date : 2023-01-01 DOI: 10.4103/jmau.jmau_90_22
C. Babu, Sandhya Tamgadge, T. Pereira, Vishal Punjabi
{"title":"Pleomorphic adenoma in an immunocompromised patient","authors":"C. Babu, Sandhya Tamgadge, T. Pereira, Vishal Punjabi","doi":"10.4103/jmau.jmau_90_22","DOIUrl":"https://doi.org/10.4103/jmau.jmau_90_22","url":null,"abstract":"","PeriodicalId":16340,"journal":{"name":"Journal of Microscopy and Ultrastructure","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70801880","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A Comparative Evaluation of Efficacy of BioMin F and Propolis Containing Toothpastes on Dentinal Tubule Occlusion with and Without Use of an Adjunct 810 nm Diode Laser: An In vitro Scanning Electron Microscope Study. 生物素F与蜂胶牙膏治疗牙本质小管闭塞的体外扫描电镜对比研究
Q3 Medicine Pub Date : 2023-01-01 DOI: 10.4103/jmau.jmau_133_20
Komal Khare, Prashant Bhusari, Abhishek Soni, Sachin K Malagi, Dennis Abraham, Lynn Johnson

Introduction: Dentinal hypersensitivity (DH) is a common chronic condition that affects a high proportion of the adult population and is one of the main reasons why patients seek dental opinion and treatment. Despite considerable success in reducing DH, unfortunately, most of the present methods can provide only temporary and unpredictable desensitization. Therefore, new treatment methods that are effective for long periods and at the same time do not have the complications are needed. Recently, two new desensitizing agents BioMin F and Propolis have been introduced for the treatment of DH.

Aim: The aim of the study was to compare and evaluate the efficacy of BioMin F and Propolis containing toothpastes on dentinal tubule occlusion with and without the use of an adjunct 810 nm Diode Laser.

Materials and methods: Forty-five freshly extracted teeth were taken out of which thirty were sectioned into halves and divided into four test groups BioMin F, Propolis, BioMin F + Laser, and Propolis + Laser and control group. All the specimens were treated twice a day for 7 days and then evaluated under scanning electron microscope for partial and complete dentinal tubule occlusion.

Results: A significantly higher number of completely occluded tubules were seen in BioMin F + laser group followed by Propolis + laser, Biomin F, and Propolis.

Conclusion: Combination approach of desensitizing agent and laser provided a better result than the desensitizing agent alone and when compared individually Biomin F was more effective desensitizer as compared to Propolis.

牙本质过敏(DH)是一种常见的慢性疾病,影响了很大比例的成年人,是患者寻求牙科意见和治疗的主要原因之一。尽管在降低DH方面取得了相当大的成功,但不幸的是,目前大多数方法只能提供暂时和不可预测的脱敏。因此,需要长期有效且无并发症的新治疗方法。最近,两种新的脱敏剂BioMin F和蜂胶被引入治疗DH。目的:比较和评价含百奥敏F牙膏和含蜂胶牙膏在辅助使用和不使用810 nm二极管激光的情况下对牙本质小管闭塞的疗效。材料与方法:取45颗新拔牙,其中30颗切成两半,分为BioMin F组、蜂胶组、BioMin F + Laser组、蜂胶+ Laser组和对照组。每天治疗2次,连续治疗7 d,然后在扫描电镜下观察部分和完全牙小管闭塞情况。结果:BioMin F +激光组完全闭塞小管数量显著高于蜂胶+激光组、BioMin F +蜂胶组。结论:激光与脱敏剂联合使用的脱敏效果优于单用脱敏剂,且百奥敏F脱敏效果优于蜂胶。
{"title":"A Comparative Evaluation of Efficacy of BioMin F and Propolis Containing Toothpastes on Dentinal Tubule Occlusion with and Without Use of an Adjunct 810 nm Diode Laser: An <i>In vitro</i> Scanning Electron Microscope Study.","authors":"Komal Khare,&nbsp;Prashant Bhusari,&nbsp;Abhishek Soni,&nbsp;Sachin K Malagi,&nbsp;Dennis Abraham,&nbsp;Lynn Johnson","doi":"10.4103/jmau.jmau_133_20","DOIUrl":"https://doi.org/10.4103/jmau.jmau_133_20","url":null,"abstract":"<p><strong>Introduction: </strong>Dentinal hypersensitivity (DH) is a common chronic condition that affects a high proportion of the adult population and is one of the main reasons why patients seek dental opinion and treatment. Despite considerable success in reducing DH, unfortunately, most of the present methods can provide only temporary and unpredictable desensitization. Therefore, new treatment methods that are effective for long periods and at the same time do not have the complications are needed. Recently, two new desensitizing agents BioMin F and Propolis have been introduced for the treatment of DH.</p><p><strong>Aim: </strong>The aim of the study was to compare and evaluate the efficacy of BioMin F and Propolis containing toothpastes on dentinal tubule occlusion with and without the use of an adjunct 810 nm Diode Laser.</p><p><strong>Materials and methods: </strong>Forty-five freshly extracted teeth were taken out of which thirty were sectioned into halves and divided into four test groups BioMin F, Propolis, BioMin F + Laser, and Propolis + Laser and control group. All the specimens were treated twice a day for 7 days and then evaluated under scanning electron microscope for partial and complete dentinal tubule occlusion.</p><p><strong>Results: </strong>A significantly higher number of completely occluded tubules were seen in BioMin F + laser group followed by Propolis + laser, Biomin F, and Propolis.</p><p><strong>Conclusion: </strong>Combination approach of desensitizing agent and laser provided a better result than the desensitizing agent alone and when compared individually Biomin F was more effective desensitizer as compared to Propolis.</p>","PeriodicalId":16340,"journal":{"name":"Journal of Microscopy and Ultrastructure","volume":"11 1","pages":"41-46"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/cb/27/JMAU-11-41.PMC10153734.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9784178","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
Gold nanoparticles down-regulate alpha fetoprotein expression induced by meloxicam hepatotoxicity in adult male albino rats: Histological and immunohistochemical study 金纳米颗粒下调美洛昔康肝毒性诱导成年雄性白化大鼠α胎儿蛋白表达的组织学和免疫组织化学研究
Q3 Medicine Pub Date : 2023-01-01 DOI: 10.4103/jmau.jmau_109_22
S. Mohammed, H. A. Aziz, Mai Nashat, A. Awaad
{"title":"Gold nanoparticles down-regulate alpha fetoprotein expression induced by meloxicam hepatotoxicity in adult male albino rats: Histological and immunohistochemical study","authors":"S. Mohammed, H. A. Aziz, Mai Nashat, A. Awaad","doi":"10.4103/jmau.jmau_109_22","DOIUrl":"https://doi.org/10.4103/jmau.jmau_109_22","url":null,"abstract":"","PeriodicalId":16340,"journal":{"name":"Journal of Microscopy and Ultrastructure","volume":"114 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70799712","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Inappropriate oral habits and mucocele in children 儿童不适当的口腔习惯和粘液囊肿
Q3 Medicine Pub Date : 2023-01-01 DOI: 10.4103/jmau.jmau_18_23
Nandhini Gunasekaran, Dineshkumar Thayalan, A. James, A. Vignesh
{"title":"Inappropriate oral habits and mucocele in children","authors":"Nandhini Gunasekaran, Dineshkumar Thayalan, A. James, A. Vignesh","doi":"10.4103/jmau.jmau_18_23","DOIUrl":"https://doi.org/10.4103/jmau.jmau_18_23","url":null,"abstract":"","PeriodicalId":16340,"journal":{"name":"Journal of Microscopy and Ultrastructure","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70800710","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A Comparison of Proliferative Capacity of Reticular and Erosive Variants of Oral Lichen Planus by Argyrophilic Nucleolar Organizer Regions Method. 用嗜银核仁组织区法比较口腔扁平苔藓网状型和侵蚀型的增殖能力。
Q3 Medicine Pub Date : 2023-01-01 DOI: 10.4103/jmau.jmau_104_20
Swati Shrikant Gotmare, Anish A Gupta, Mandavi Waghmare, Pratibha Kavle, Asha Rathod, Sushma Sonawne, Treville Pereira

Background: Oral lichen planus (OLP), an immune mediated disorder, has been recognized since 1869 and is presented as any one of the six variants. Reticular and erosive are the most frequently encountered. Its proliferative capacity can give some information regarding its progression. We adopted the argyrophilic nucleolar organizer regions (AgNORs) method because of its simplicity to use and dependable results. We evaluated AgNORs in basal, suprabasal, and squamous cell layers. We also compared these three layers within two variants, reticular, and erosive.

Materials and methods: Thirty clinically diagnosed patients of OLP were included in the study. Reticular and erosive variants were included in our study. This was followed by hematoxylin and eosin staining and later by the AgNOR method. The mean number of AgNORs per nucleus was calculated.

Results: Thirteen males and 17 females were the gender distribution. Twenty-three (76.67%) had reticular pattern and seven (23.33%) had erosive pattern. The basal cell layer had the highest mean AgNOR compared to suprabasal and squamous layers. Even among, erosive and reticular variants, the former had higher mean AgNOR counts.

Discussion: Our results suggest that the inflammatory infiltrate close to the epithelial cells can alter the proliferation index for the pattern of protein synthesis of these cells. Moreover, the high proliferative index in OLP can be related to a specific immunologic response.

Conclusion: We conclude that AgNOR can be used as a proliferative marker in earlier lesions to detect the severity.

背景:口腔扁平苔藓(OLP)是一种免疫介导的疾病,自1869年以来一直被发现,并表现为六种变体中的任何一种。网状和侵蚀是最常见的。其增殖能力可以提供有关其进展的一些信息。我们采用亲银核仁组织区(AgNORs)方法,因为它使用简单,结果可靠。我们评估了基底、基底上和鳞状细胞层的AgNORs。我们还比较了这三层的两种变体,网状层和侵蚀层。材料与方法:选取30例临床诊断为OLP的患者。我们的研究包括网状和侵蚀型变异。随后进行苏木精和伊红染色,再进行AgNOR染色。计算每个细胞核中AgNORs的平均数目。结果:男性13例,女性17例。网状纹23例(76.67%),侵蚀纹7例(23.33%)。基底细胞层的平均AgNOR高于基底上层和鳞状层。即使在侵蚀型和网状型变异中,前者也有较高的平均AgNOR计数。讨论:我们的研究结果表明,炎症浸润靠近上皮细胞可以改变这些细胞的蛋白质合成模式的增殖指数。此外,OLP的高增殖指数可能与特定的免疫反应有关。结论:AgNOR可以作为早期病变的增殖标志物来检测病变的严重程度。
{"title":"A Comparison of Proliferative Capacity of Reticular and Erosive Variants of Oral Lichen Planus by Argyrophilic Nucleolar Organizer Regions Method.","authors":"Swati Shrikant Gotmare,&nbsp;Anish A Gupta,&nbsp;Mandavi Waghmare,&nbsp;Pratibha Kavle,&nbsp;Asha Rathod,&nbsp;Sushma Sonawne,&nbsp;Treville Pereira","doi":"10.4103/jmau.jmau_104_20","DOIUrl":"https://doi.org/10.4103/jmau.jmau_104_20","url":null,"abstract":"<p><strong>Background: </strong>Oral lichen planus (OLP), an immune mediated disorder, has been recognized since 1869 and is presented as any one of the six variants. Reticular and erosive are the most frequently encountered. Its proliferative capacity can give some information regarding its progression. We adopted the argyrophilic nucleolar organizer regions (AgNORs) method because of its simplicity to use and dependable results. We evaluated AgNORs in basal, suprabasal, and squamous cell layers. We also compared these three layers within two variants, reticular, and erosive.</p><p><strong>Materials and methods: </strong>Thirty clinically diagnosed patients of OLP were included in the study. Reticular and erosive variants were included in our study. This was followed by hematoxylin and eosin staining and later by the AgNOR method. The mean number of AgNORs per nucleus was calculated.</p><p><strong>Results: </strong>Thirteen males and 17 females were the gender distribution. Twenty-three (76.67%) had reticular pattern and seven (23.33%) had erosive pattern. The basal cell layer had the highest mean AgNOR compared to suprabasal and squamous layers. Even among, erosive and reticular variants, the former had higher mean AgNOR counts.</p><p><strong>Discussion: </strong>Our results suggest that the inflammatory infiltrate close to the epithelial cells can alter the proliferation index for the pattern of protein synthesis of these cells. Moreover, the high proliferative index in OLP can be related to a specific immunologic response.</p><p><strong>Conclusion: </strong>We conclude that AgNOR can be used as a proliferative marker in earlier lesions to detect the severity.</p>","PeriodicalId":16340,"journal":{"name":"Journal of Microscopy and Ultrastructure","volume":"11 1","pages":"12-16"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/8d/b1/JMAU-11-12.PMC10153732.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9416899","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
期刊
Journal of Microscopy and Ultrastructure
全部 Acc. Chem. Res. ACS Applied Bio Materials ACS Appl. Electron. Mater. ACS Appl. Energy Mater. ACS Appl. Mater. Interfaces ACS Appl. Nano Mater. ACS Appl. Polym. Mater. ACS BIOMATER-SCI ENG ACS Catal. ACS Cent. Sci. ACS Chem. Biol. ACS Chemical Health & Safety ACS Chem. Neurosci. ACS Comb. Sci. ACS Earth Space Chem. ACS Energy Lett. ACS Infect. Dis. ACS Macro Lett. ACS Mater. Lett. ACS Med. Chem. Lett. ACS Nano ACS Omega ACS Photonics ACS Sens. ACS Sustainable Chem. Eng. ACS Synth. Biol. Anal. Chem. BIOCHEMISTRY-US Bioconjugate Chem. BIOMACROMOLECULES Chem. Res. Toxicol. Chem. Rev. Chem. Mater. CRYST GROWTH DES ENERG FUEL Environ. Sci. Technol. Environ. Sci. Technol. Lett. Eur. J. Inorg. Chem. IND ENG CHEM RES Inorg. Chem. J. Agric. Food. Chem. J. Chem. Eng. Data J. Chem. Educ. J. Chem. Inf. Model. J. Chem. Theory Comput. J. Med. Chem. J. Nat. Prod. J PROTEOME RES J. Am. Chem. Soc. LANGMUIR MACROMOLECULES Mol. Pharmaceutics Nano Lett. Org. Lett. ORG PROCESS RES DEV ORGANOMETALLICS J. Org. Chem. J. Phys. Chem. J. Phys. Chem. A J. Phys. Chem. B J. Phys. Chem. C J. Phys. Chem. Lett. Analyst Anal. Methods Biomater. Sci. Catal. Sci. Technol. Chem. Commun. Chem. Soc. Rev. CHEM EDUC RES PRACT CRYSTENGCOMM Dalton Trans. Energy Environ. Sci. ENVIRON SCI-NANO ENVIRON SCI-PROC IMP ENVIRON SCI-WAT RES Faraday Discuss. Food Funct. Green Chem. Inorg. Chem. Front. Integr. Biol. J. Anal. At. Spectrom. J. Mater. Chem. A J. Mater. Chem. B J. Mater. Chem. C Lab Chip Mater. Chem. Front. Mater. Horiz. MEDCHEMCOMM Metallomics Mol. Biosyst. Mol. Syst. Des. Eng. Nanoscale Nanoscale Horiz. Nat. Prod. Rep. New J. Chem. Org. Biomol. Chem. Org. Chem. Front. PHOTOCH PHOTOBIO SCI PCCP Polym. Chem.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1