Journal of oral biology and craniofacial research最新文献_第2页

In-vitro mechanical performance of three CAD-CAM bar designs for implant-supported metal–resin hybrid prostheses: a preliminary pilot study 三种CAD-CAM杆设计用于种植体支撑的金属-树脂混合假体的体外力学性能：初步试点研究

Q1 Medicine

Journal of oral biology and craniofacial research

Pub Date : 2026-01-20 DOI: 10.1016/j.jobcr.2026.101407

Arteaga-Losada Lorena , Laura-Fernadez Héctor , Puerta-Dominguez María Alejandra , Ascaso-Terren Carlos , Vives Eduard , Escuin-Henar Tomás , Torné-Durán Sergi

Background

Implant-supported hybrid metal–resin prostheses are widely used to rehabilitate edentulous patients. However, fractures of the veneering resin and screw complications remain common mechanical failures. Advances in CAD-CAM design and laser sintering technology may improve the structural integrity of these restorations.

Aims

To conduct a preliminary in-vitro evaluation of the fracture resistance of veneering resin in three CAD-CAM–designed bar configurations fabricated by laser sintering, describing their mechanical behavior and failure patterns under compressive stress.

Methods

Three bar designs (inverted T, L-shaped, and Ackerman circular) were digitally created and manufactured in cobalt–chromium using laser sintering. Each bar was veneered with autopolymerizing acrylic resin and subjected to compressive loading up to 1000 N at a 30° angle, in accordance with ISO 14801. Simultaneously, acoustic emission analysis was performed to detect microcracks and structural failures.

Results

No fractures of the veneering resin were observed. Mechanical failures occurred as deformation or fracture of prosthetic screws, beginning at 600 N. Acoustic emission detected early microcracks between 160 N and 400 N, and main fracture peaks between 627 N and 871 N. Among the three samples, the inverted T-shaped bar sustained the highest load before failure in this pilot test.

Conclusion

In this pilot in-vitro study, the veneering resin showed high resistance under simulated masticatory loading. The combination of CAD-CAM design, laser-sintered fabrication, and retentive elements may enhance mechanical performance. Further studies with larger sample sizes and cyclic loading are warranted to validate these preliminary findings.

植物支撑金属-树脂复合修复体广泛应用于无牙患者的修复。然而，贴面树脂骨折和螺钉并发症仍然是常见的机械故障。CAD-CAM设计和激光烧结技术的进步可以提高这些修复体的结构完整性。目的对三种由cad - cam设计的激光烧结棒材中贴面树脂的抗断裂性能进行初步体外评估，描述它们在压应力下的力学行为和破坏模式。方法采用激光烧结技术在钴铬合金中数字化制作3种棒材（倒T形、l形和Ackerman圆形）。每个棒都贴有自聚合丙烯酸树脂，并按照ISO 14801标准，在30°角处承受高达1000 N的压缩载荷。同时，进行声发射分析以检测微裂纹和结构破坏。结果未见贴面树脂断裂。在600 N时，假体螺钉发生变形或断裂，声发射在160 N ~ 400 N之间检测到早期微裂纹，在627 N ~ 871 N之间检测到主要断裂峰。在3个样品中，本次中试中，倒t形杆在失效前承受的载荷最高。结论在体外实验中，贴面树脂在模拟咀嚼负荷下表现出较高的抗咬性能。结合CAD-CAM设计、激光烧结制造和固位元件可以提高机械性能。进一步的研究与更大的样本量和循环加载是必要的，以验证这些初步发现。

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引用次数: 0

Tooth loss among adults with and without presence of systemic diseases – Age and Gender matched case control study 有和不存在全身性疾病的成年人牙齿脱落——年龄和性别匹配的病例对照研究

Q1 Medicine

Journal of oral biology and craniofacial research

Pub Date : 2026-01-20 DOI: 10.1016/j.jobcr.2026.01.007

Deshpande Vijaya Lakshmi, S. Jagadeeswara Rao, Dolar Doshi, Twinkle Tiwari, Lunavath Preethi

Background

Systemic diseases contribute to tooth loss by affecting immunity, circulation, and bone health. While most studies focus on elderly, this study assesses tooth loss among adults with and without systemic diseases to support early care.

Aim

To assess tooth loss among adults with and without systemic diseases in age- and gender-matched cases and controls.

Design

A case-control study was conducted among 280 adults (140 cases and 140 controls). Data on demographics, lifestyle factors (alcohol, smoking, oral hygiene), and systemic diseases were collected. Tooth loss was assessed using Tooth Loss Index. Statistical analysis included Chi-square, Mann-Whitney U test, logistic regression, and correlation analysis.

Results

Cases had higher rates of alcohol use, smoking, and poor oral hygiene (p < 0.05). Tooth loss was significantly higher among cases (87.1 %) than controls (50 %), with greater mean missing teeth and higher Tooth Loss Index scores. Low education, alcohol, and smoking were significantly associated with increased tooth loss. Cases had nearly four times higher odds of significant tooth loss (OR = 3.82, p = 0.0001), with a strong positive correlation. (r = 0.82, p = 0.0001).

Conclusion

Systemic diseases are strongly associated with increased tooth loss in adults, highlighting need for early oral health interventions.

背景：全身性疾病通过影响免疫力、血液循环和骨骼健康而导致牙齿脱落。虽然大多数研究都集中在老年人身上，但本研究评估了有和没有全身性疾病的成年人的牙齿脱落情况，以支持早期护理。目的在年龄和性别匹配的病例和对照组中评估有和没有全身性疾病的成年人的牙齿脱落情况。设计对280名成人进行病例对照研究（140例和140例对照）。收集了人口统计学、生活方式因素（酒精、吸烟、口腔卫生）和全身性疾病的数据。采用牙损指数评估牙损情况。统计分析包括卡方检验、Mann-Whitney U检验、logistic回归和相关分析。结果患者饮酒、吸烟、口腔卫生不良发生率较高（p < 0.05）。病例中牙齿脱落率（87.1%）明显高于对照组（50%），平均缺失牙数和牙齿脱落指数得分均较高。受教育程度低、饮酒和吸烟与牙齿脱落的增加显著相关。病例发生明显牙齿脱落的几率高出近4倍（OR = 3.82, p = 0.0001），且呈正相关。（r = 0.82, p = 0.0001）。结论全身性疾病与成人牙齿脱落增加密切相关，强调早期口腔健康干预的必要性。

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引用次数: 0

Comparative analysis between resin-based root canal sealer and recent bioceramic-based root canal sealers using MicroCT, film thickness, and solubility 使用MicroCT、膜厚度和溶解度对树脂基根管密封剂和生物陶瓷基根管密封剂进行比较分析

Q1 Medicine

Journal of oral biology and craniofacial research

Pub Date : 2026-01-20 DOI: 10.1016/j.jobcr.2026.01.004

Amira Galal Ismail, Manar M. Galal, Tamer M. Hamdy

Background

This study is aimed at evaluating the sealing quality of the single cone obturation technique with resin-based root canal sealers (ADseal root canal sealers, control group) and the novel hydraulic bioceramic-based sealers (Fill Root ST and AH Plus Bioceramic sealers). The assessment was performed by micro-CT void analysis. In addition, film thickness and solubility of the sealers were also evaluated.

Materials and methods

Voids were evaluated on clear acrylic resin blocks with a standard artificial root canal model using micro-CT. Physical analysis of the sealers assessed film thickness and solubility. Statistical analysis included one-way ANOVA with Tukey's post-hoc test for multiple comparisons and repeated measure ANOVA for related samples.

Results

The AH Plus Bioceramic Sealer exhibited the least canal voids (5.70 %), while the Fill Root ST had intermediate voids, and ADseal had the highest (p < 0.001). The coronal third had the most voids, followed by the middle and apical thirds (p < 0.001). AH Plus Bioceramic Sealer had the thinnest film thickness (19.3 μm), followed by Fill Root ST (42.7 μm), and ADseal (81.7 μm) (p < 0.001). In solubility, ADseal had the lowest (0.9 %), Fill Root ST the highest (2.4 %), and AH Plus Bioceramic intermediate (1.5 %) (p < 0.001).

Conclusions

The bioceramic-based sealers (Fill Root ST and AH Plus Bioceramic) showed superior performance compared to ADseal in terms of void formation and film thickness, with voids most frequent in the coronal third and least in the apical third.

本研究旨在评价树脂根管密封剂（ADseal根管密封剂，对照组）和新型液压生物陶瓷根管密封剂（Fill root ST和AH Plus生物陶瓷根管密封剂）的单锥封闭技术的密封质量。通过微ct空隙分析进行评估。此外，还对密封剂的膜厚和溶解度进行了评价。材料与方法采用micro-CT对透明丙烯酸树脂块与标准人工根管模型的空隙进行评价。封口剂的物理分析评估了薄膜厚度和溶解度。统计分析包括单因素方差分析，采用Tukey事后检验进行多重比较，并对相关样本进行重复测量方差分析。结果AH +生物陶瓷密封器的根管空隙最少（5.70%），充填根管ST为中等空隙，ADseal为最高（p < 0.001）。冠状三分之一有最多的空隙，其次是中间和根尖三分之一（p < 0.001）。AH Plus Bioceramic Sealer的膜厚最薄（19.3 μm），其次是Fill Root ST （42.7 μm）和ADseal (81.7 μm) （p < 0.001）。在溶解度方面，ADseal最低（0.9%），Fill Root ST最高（2.4%），AH Plus生物陶瓷中间体（1.5%）（p < 0.001）。结论生物陶瓷基材（充填根ST和AH +生物陶瓷）在空洞形成和膜厚度方面优于ADseal，空洞在冠状三分之一最常见，在根尖三分之一最少。

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引用次数: 0

Effect of surface preparation methods on the shear bond strength of universal and self-etch adhesive systems: an in vitro study 表面处理方法对通用和自蚀刻胶粘剂系统剪切结合强度的影响：体外研究

Q1 Medicine

Journal of oral biology and craniofacial research

Pub Date : 2026-01-19 DOI: 10.1016/j.jobcr.2026.101408

Shiwangi Verma , Ravishankar Suman , Rajendra Goud , Snigdho Das , Srikant Gollapudi , Samapika Routray

Objectives

To assess the impact of three smear layer preparation methods on shear bond strength (SBS) to enamel and dentin, using two universal adhesives (Tetric N-Bond Universal, 3M Single Bond Universal) and one two-step self-etch adhesive (Kuraray Clearfil SE Bond).

Methods

Ninety extracted premolars were assigned to enamel and dentin groups (n = 45 each) and prepared with coarse grit (120), fine grit (600) silicon carbide paper, or air abrasion (Aluminium Oxide for enamel, Sylc for dentin). Surfaces were bonded with one of the adhesives and restored with composite. Enamel was treated in an etch-and-rinse mode, dentin in self-etch mode. SBS was tested using a universal testing machine. Failure surfaces were examined under SEM to assess fracture morphology and EDS to determine elemental composition. Data were analyzed using two-way ANOVA/Tukey's post-hoc test and Weibull statistics (P ≤ 0.05).

Results

In enamel, SBS generally increased from coarse to fine to air abrasion. Kuraray Clearfil SE Bond yielded the highest values, particularly with air abrasion (9.11 ± 0.51 MPa). In dentin, fine grit achieved the highest SBS across all adhesives, followed by air abrasion; coarse grit showed the lowest. Kuraray consistently outperformed the universal adhesives in most dentin conditions. SEM/EDS revealed predominantly adhesive failures; occasional cohesive failures in dentin (Ivoclar) and enamel (Kuraray) corresponded with higher SBS and Weibull reliability.

Conclusion

Both surface preparation and adhesive type significantly influence SBS. Kuraray showed superior performance and reliability, while fine grit and air abrasion enhanced bonding efficacy. SEM/EDS findings corroborated the mechanical results.

目的采用两种通用胶粘剂（Tetric N-Bond universal、3M Single bond universal）和一种两步自蚀刻胶粘剂（Kuraray Clearfil SE bond），评价三种涂抹层制备方法对牙釉质和牙本质剪切结合强度（SBS）的影响。方法将90颗拔除的前磨牙分为牙本质组和牙釉质组，每组45颗，分别用粗磨（120颗）、细磨（600颗）碳化硅纸或空气磨蚀（氧化铝磨蚀牙釉质，硫胺磨蚀牙本质）进行磨蚀。用其中一种粘合剂粘合表面，并用复合材料修复。牙釉质采用蚀刻-冲洗模式，牙本质采用自蚀刻模式。使用通用试验机对SBS进行了测试。在扫描电镜和能谱下对断裂表面进行了检查，以评估断裂形态和确定元素组成。数据分析采用双因素方差分析/Tukey事后检验和威布尔统计（P≤0.05）。结果在牙釉质中，SBS由粗到细再到气蚀逐渐增加。Kuraray Clearfil SE Bond获得了最高的值，特别是在空气磨损时（9.11±0.51 MPa）。在牙本质中，细砂在所有粘合剂中SBS最高，其次是空气磨损；粗粒度最低。在大多数牙本质条件下，Kuraray始终优于通用粘接剂。SEM/EDS主要显示胶粘剂失效；牙本质（Ivoclar）和牙釉质（Kuraray）偶尔的内聚失败与较高的SBS和Weibull可靠性相对应。结论表面处理和黏合剂类型对SBS均有显著影响。Kuraray表现出优异的性能和可靠性，而细粒度和空气磨损则增强了粘接效果。SEM/EDS结果证实了力学结果。

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引用次数: 0

Economic burden and economic impact of oral diseases in India: A systematic review and meta-analysis 印度口腔疾病的经济负担和经济影响：系统回顾和荟萃分析

Q1 Medicine

Journal of oral biology and craniofacial research

Pub Date : 2026-01-19 DOI: 10.1016/j.jobcr.2026.01.006

Vineetha Karuveettil , Chandrashekar Janakiram , Aparna Ramachandran , Denny John

Objective

To quantify the economic burden and financial impact of oral diseases in India—on individuals, households, the health system, and society—focusing on direct and indirect costs and out-of-pocket expenditure (OOPE).

Methods

Following JBI methodology and PRISMA 2020, we conducted a three-step search of MEDLINE, Embase, Scopus, CINAHL, DOSS, Cochrane CENTRAL, and grey literature. We included India-based studies reporting economic burden/financial impact at individual, household, or population levels. Eligible designs were cost-of-illness, cost/expenditure analyses, and cohort or cross-sectional studies; mixed-methods with extractable quantitative data were included. Two reviewers independently screened, appraised (JBI tools), and extracted data on direct/indirect costs, OOPE, catastrophic expenditure (CHE), and hardship financing. Findings were narratively synthesized; meta-analysis was undertaken in JBI SUMARI where appropriate.

Results

Of 1684 records, 15 met inclusion criteria, mostly cross-sectional across states. OOPE varied widely; oral-cancer treatment often ranged from INR 80,000 to over INR 2,30,000. Direct costs were higher in private settings; indirect productivity losses were reported. CHE ranged from 0.6 % to 96 % across definitions; pooling studies using the ≥20 % income threshold yielded a CHE prevalence of 18.8 %. Insurance coverage was low (<15 %) with limited protection. Up to one-third of patients relied on hardship financing (borrowing or asset sales).

Conclusion

Oral diseases impose a substantial economic burden in India, characterised by high OOPE, elevated CHE risk (pooled 18.8 %), and frequent distress financing. Priorities include stronger national data, standardised costing/reporting (price year, components, variance), and expanded financial protection to reduce household hardship and advance universal oral health coverage.

Systematic review registration number

The protocol is prospectively registered in the International Prospective Register of Systematic Reviews database (PROSPERO ID: CRD420251030651).

目的量化印度口腔疾病对个人、家庭、卫生系统和社会的经济负担和财政影响，重点关注直接和间接成本和自付费用（OOPE）。方法采用JBI方法学和PRISMA 2020，对MEDLINE、Embase、Scopus、CINAHL、DOSS、Cochrane CENTRAL和灰色文献进行三步检索。我们纳入了以印度为基础的研究，报告了个人、家庭或人口水平上的经济负担/财务影响。符合条件的设计是疾病成本、成本/支出分析和队列或横断面研究；包括可提取定量数据的混合方法。两位审稿人独立筛选、评估（JBI工具），并提取了直接/间接成本、OOPE、灾难性支出（CHE）和困难融资方面的数据。研究结果以叙述方式综合；适当时在JBI SUMARI中进行meta分析。结果在1684份记录中，有15份符合纳入标准，大部分是跨州的横截面记录。OOPE变化很大；口腔癌的治疗费用通常在8万卢比到23万卢比以上。私人部门的直接成本更高；有间接生产力损失的报告。不同定义的CHE范围从0.6%到96%；采用≥20%收入阈值的合并研究得出CHE患病率为18.8%。保险覆盖率很低（15%），保障有限。多达三分之一的患者依靠困难融资（借款或出售资产）。结论口腔疾病在印度造成了巨大的经济负担，其特点是口腔疾病发生率高，CHE风险升高（合计18.8%），以及频繁的紧急融资。优先事项包括加强国家数据、标准化成本核算/报告（价格年度、组成部分、差异）和扩大财务保护，以减少家庭困难和推进全民口腔健康覆盖。该方案已在国际前瞻性系统评价注册数据库（PROSPERO ID: CRD420251030651）中前瞻性注册。

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引用次数: 0

Comparison of effectiveness of hyaluronic acid and melatonin with guided tissue regeneration (GTR) membrane versus guided tissue regeneration (GTR) membrane alone in the treatment of intra-bony defects in human subjects: A split-mouth randomised controlled clinical trial 透明质酸和褪黑素联合引导组织再生膜（GTR）与单独引导组织再生膜（GTR）治疗人类骨内缺损的疗效比较：一项裂口随机对照临床试验

Q1 Medicine

Journal of oral biology and craniofacial research

Pub Date : 2026-01-16 DOI: 10.1016/j.jobcr.2026.01.001

Subasree Soundarajan, Sankari Malaiappan

Background

Melatonin is one substance that is primarily generated by the pineal gland and numerous other tissues and has vital involvement in many physiological processes, including bone remodeling. Over the last several years, another emerging molecule serving as a potential candidate for periodontal regeneration is the hyaluronic acid (HA), a key extracellular matrix component involved in cell migration. The aim of this study is the additive effect of hyaluronic acid and melatonin with GTR membrane in intrabony defects among patients with chronic periodontitis.

Materials and methods

15 bilateral intra-bony defects were treated either with Hyaluronic acid and melatonin along with GTR membrane (Group I), or GTR membrane alone (Group II). Clinical and radiographic parameters assessed were pocket depth, clinical attachment level, and volume of bone defect at baseline and 6 months after the intervention. The biochemical parameter assessed was Matrix metalloproteinase - 1 (MMP-1) and Tissue inhibitor of metalloproteinase (TIMP-1) at baseline and one month after the intervention.

Results

Both the study groups showed statistically significant differences in all the parameters from baseline to follow-up. However, group 1 (Hyaluronic acid + Melatonin + GTR membrane) showed statistically significant improvement in all the study parameters when compared to group 2 (GTR alone).

Conclusion

It can be concluded that the combination of hyaluronic acid and melatonin was effective in the regeneration of intrabony defects among patients with chronic periodontitis. However, further studies with a longer time period and with additional microbiological assessment would be desirable so as to substantiate the current results.

褪黑素是一种主要由松果体和许多其他组织产生的物质，在许多生理过程中起重要作用，包括骨重塑。在过去的几年里，另一个作为牙周再生的潜在候选分子是透明质酸（HA），它是参与细胞迁移的关键细胞外基质成分。本研究的目的是观察透明质酸和褪黑素与GTR膜对慢性牙周炎患者骨内缺损的加性作用。材料与方法15例双侧骨内缺损采用透明质酸、褪黑素联合GTR膜治疗（I组），GTR膜治疗（II组）。评估的临床和影像学参数包括基线和干预后6个月时的骨袋深度、临床附着水平和骨缺损体积。在基线和干预后1个月评估基质金属蛋白酶-1 （MMP-1）和金属蛋白酶组织抑制剂（TIMP-1）的生化参数。结果两个研究组从基线到随访的所有参数均有统计学差异。然而，与2组（单独使用GTR）相比，1组（透明质酸+褪黑素+ GTR膜）在所有研究参数上均有统计学意义的改善。结论透明质酸联合褪黑素治疗慢性牙周炎骨内缺损有较好的再生效果。然而，为了证实目前的结果，需要进行更长的时间和额外的微生物评估的进一步研究。

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引用次数: 0

Regional odontodysplasia: a report of unusual case with in-depth analysis 局部牙发育不良：罕见病例报告并深入分析

Q1 Medicine

Journal of oral biology and craniofacial research

Pub Date : 2026-01-15 DOI: 10.1016/j.jobcr.2025.12.012

Charles Béhot , Ophélie Cuisinier , Éden Serraf , Lisa Friedlander , Brigitte Vi-Fane , Pascal Garrec , Ali Nassif

Background/purpose

Regional odontodysplasia (RO) is a rare developmental anomaly affecting dental tissue formation, typically confined to a single quadrant. It manifests through hypoplastic enamel, irregular dentin, short roots with open apices, and a characteristic “ghost-like” radiographic appearance. Its etiology remains unclear, with vascular, genetic and inflammatory factors proposed.

Materials and methods

In this study, we report the case of a 15-year-old female with mandibular RO affecting canine, premolars, and molars, focusing on the clinical, radiographic, and microscopic analysis of the affected teeth, including mineral density evaluation.

Results

The 2nd premolar and first and second molars (teeth 35, 36, 37) exhibited severe morphological defects and were extracted due to extreme root shortening (40 %, 90 %, and >95 % reduction), while alveolar bone height remained preserved. The canine and 1st premolar were affected to a lesser extent and were conserved upon orthodontic treatment plan. Scanning electron microscopy revealed slight decreases in the number and diameter of the dentinal tubules in the affected teeth compared with those in the control teeth. Contrary to many reported cases of RO, mineral density analysis of enamel and dentin revealed no significant differences between affected and normal teeth. The observations reported in this case suggest that resorptive changes, possibly influenced by inflammatory factors, could contribute to the observed root anomalies. The preservation of alveolar bone height provides a favourable prognosis for prosthetic rehabilitation.

Conclusion

These findings help elucidate the structural and functional implications of ROs. This study highlights the importance of early diagnosis and multidisciplinary management for optimal outcomes.

背景/目的局部牙发育不良（RO）是一种罕见的影响牙齿组织形成的发育异常，通常局限于单一象限。表现为牙釉质发育不全，牙本质不规则，根短尖开，影像学表现为“鬼影样”。其病因尚不清楚，血管，遗传和炎症因素提出。材料和方法在本研究中，我们报告了一名15岁的女性下颌RO影响犬齿，前磨牙和磨牙的病例，重点是对受影响牙齿的临床，x线摄影和显微镜分析，包括矿物质密度评估。结果第2前磨牙和第1、2磨牙（35、36、37牙）形态缺损严重，根极短（减少40%、90%、95%）拔除，但牙槽骨高度保持不变。犬齿和第一前磨牙受影响较小，按正畸治疗方案保留。扫描电镜显示，与对照组相比，患牙的牙本质小管数量和直径略有减少。与许多报道的RO病例相反，牙釉质和牙本质的矿物质密度分析显示，受影响的牙齿和正常牙齿之间没有显着差异。本病例报告的观察结果表明，可能受炎症因素影响的吸收变化可能导致观察到的根异常。保留牙槽骨高度为修复提供了良好的预后。结论这些发现有助于阐明活性氧的结构和功能意义。这项研究强调了早期诊断和多学科管理对最佳结果的重要性。

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引用次数: 0

A hybrid MMBERT framework for classifying periodontal bone loss: Integrating visual and textual information 一个用于牙周骨丢失分类的混合MMBERT框架：整合视觉和文本信息

Q1 Medicine

Journal of oral biology and craniofacial research

Pub Date : 2026-01-14 DOI: 10.1016/j.jobcr.2025.12.013

Jennifer Jeyaruby, Pradeep Kumar Yadalam

Introduction

Periodontitis, a chronic inflammatory disease, causes bone loss and tooth instability. Early diagnosis, aided by clinical and radiographic assessments, is crucial. mmBERT, a multimodal deep learning approach, integrates image and text data to enhance bone loss prediction but faces challenges such as image variability and limited datasets. This study proposes a Hybrid mmBERT Framework to improve diagnostic accuracy in intraoral periapical (IOPA) radiographs.

Methods

A dataset of 150 IOPA images from Saveetha Dias includes expert-annotated interpretations of periodontal bone loss. Images are split into training and test sets. Clinical notes are preprocessed, normalized, and feature-extracted using ClinicalBERT. The mmBERT model fuses image and text embeddings into a 1024-dimensional space with a 0.3 dropout rate. Its architecture integrates a vision encoder (ResNet50), text encoder (ClinicalBERT), and a cross-modal transformer with 16 attention heads.

Results

The study shows strong overlap between predicted and ground-truth masks, good intersection-over-union performance, and acceptable boundary accuracy. The MMBERT model achieved final training and test accuracies of 99.11 % and 100 %, respectively, demonstrating its robustness and reliability in clinical applications.

Conclusion

The study presents a classification method for periodontal bone loss based on MMBERT architecture. It demonstrates promising radiographic interpretation performance while necessitating further clinical application research.

牙周炎是一种慢性炎症性疾病，会导致骨质流失和牙齿不稳定。在临床和放射学评估的帮助下进行早期诊断至关重要。mmBERT是一种多模态深度学习方法，它集成了图像和文本数据来增强骨质流失预测，但面临着图像可变性和数据集有限等挑战。本研究提出了一种混合mmBERT框架，以提高口腔内根尖周（IOPA） x线片的诊断准确性。方法来自Saveetha Dias的150张IOPA图像数据集包括专家注释的牙周骨质流失解释。图像分为训练集和测试集。使用ClinicalBERT对临床记录进行预处理、归一化和特征提取。mmBERT模型将图像和文本嵌入融合到1024维空间中，辍学率为0.3。它的架构集成了一个视觉编码器（ResNet50）、文本编码器（ClinicalBERT）和一个具有16个注意力头的跨模态转换器。结果预测掩模与真实掩模之间有较强的重叠，具有良好的交叉-超并性能，边界精度可接受。MMBERT模型的最终训练和测试准确率分别达到99.11%和100%，证明了其在临床应用中的鲁棒性和可靠性。结论提出了一种基于MMBERT结构的牙周骨丢失分类方法。它显示了良好的影像学解释性能，但需要进一步的临床应用研究。

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引用次数: 0

Comparison of ozone therapy and antimicrobial photodynamic therapy in periodontitis: A randomized clinical trial 臭氧治疗与抗菌光动力治疗牙周炎的比较：一项随机临床试验

Q1 Medicine

Journal of oral biology and craniofacial research

Pub Date : 2026-01-13 DOI: 10.1016/j.jobcr.2025.12.011

Shilpi Mangal , Shalini Kaushal , Nand Lal , Anjani Kumar Pathak , Bhaskar Agarwal , Suruchi Shukla

Background

This randomized clinical trial evaluated the comparative efficacy of ozone therapy and ICG-mediated antimicrobial photodynamic therapy as adjunctive to scaling and root planing in the management of periodontitis, by assessing clinical outcomes, inflammatory biomarkers, specifically interleukin-1β (IL-1β) and Pentraxin-3 (PTX-3), and microbial load via quantitative PCR.

Methods

This is a parallel-arm, single-blinded, randomized controlled trial that included 36 patients with Stage III Grade B periodontitis, allocated randomly to three groups. Group 1 {Scaling and Root planing (SRP)}, Group 2 {SRP + Ozone Therapy (OT}), and Group 3 {SRP + Antimicrobial Photodynamic Therapy (aPDT)}. Clinical parameters, biochemical markers, and microbial count were recorded at baseline, 1 month, and 3 months.

Result

The change in Plaque Index (PI), Gingival Index (GI), Probing Pocket Depth (PPD), and Clinical Attachment Level (CAL) from baseline to 1 month and from baseline to 3 months was significantly higher in the SRP + OT group (p < 0.001). Reduction in the microbial count of Porphyromonas gingivalis (Keystone pathogen) (Mean difference = −0.70, p < 0.001) and Tannerella forsythia (−0.51, p < 0.001), whereas SRP + aPDT provided superior suppression for Fusobacterium nucleatum (−0.76, p < 0.001) and Prevotella intermedia (0.40, p < 0.001). No meaningful difference was observed between the two adjuncts for Treponema denticola (p = 0.994).

Conclusion

All treatment modalities resulted in significant improvements in all the parameters over time. However, SRP + Ozone Therapy consistently achieved the improvement across all parameters, when compared to SRP alone or SRP with aPDT.

本随机临床试验通过定量PCR评估临床结果、炎症生物标志物，特别是白细胞介素-1β (IL-1β)和ptraxin -3 (PTX-3)，以及微生物负荷，评估臭氧治疗和icg介导的抗菌光动力治疗在牙周炎治疗中的辅助效果。方法：这是一项平行、单盲、随机对照试验，包括36例III期B级牙周炎患者，随机分为三组。1组{除垢和刨根（SRP）}， 2组{SRP +臭氧治疗（OT）}， 3组{SRP +抗菌光动力治疗（aPDT）}。在基线、1个月和3个月记录临床参数、生化指标和微生物计数。结果SRP + OT组牙菌斑指数（PI）、牙龈指数（GI）、探查袋深度（PPD）、临床附着水平（CAL）的变化较对照组（p < 0.001）显著升高。减少了牙龈卟啉单胞菌（Keystone病原菌）（平均差值= - 0.70,p < 0.001）和连铸单宁菌（- 0.51,p < 0.001）的微生物数量，而SRP + aPDT对核梭杆菌（- 0.76,p < 0.001）和中间普氏菌（0.40,p < 0.001）具有较好的抑制作用。密螺旋体和齿状体的检测结果无显著性差异（p = 0.994）。结论随着时间的推移，所有治疗方式均能显著改善患者的各项指标。然而，与单独SRP或SRP + aPDT相比，SRP +臭氧疗法在所有参数上都得到了持续的改善。

{"title":"Comparison of ozone therapy and antimicrobial photodynamic therapy in periodontitis: A randomized clinical trial","authors":"Shilpi Mangal , Shalini Kaushal , Nand Lal , Anjani Kumar Pathak , Bhaskar Agarwal , Suruchi Shukla","doi":"10.1016/j.jobcr.2025.12.011","DOIUrl":"10.1016/j.jobcr.2025.12.011","url":null,"abstract":"<div><h3>Background</h3><div>This randomized clinical trial evaluated the comparative efficacy of ozone therapy and ICG-mediated antimicrobial photodynamic therapy as adjunctive to scaling and root planing in the management of periodontitis, by assessing clinical outcomes, inflammatory biomarkers, specifically interleukin-1β (IL-1β) and Pentraxin-3 (PTX-3), and microbial load via quantitative PCR.</div></div><div><h3>Methods</h3><div>This is a parallel-arm, single-blinded, randomized controlled trial that included 36 patients with Stage III Grade B periodontitis, allocated randomly to three groups. Group 1 {Scaling and Root planing (SRP)}, Group 2 {SRP + Ozone Therapy (OT}), and Group 3 {SRP + Antimicrobial Photodynamic Therapy (aPDT)}. Clinical parameters, biochemical markers, and microbial count were recorded at baseline, 1 month, and 3 months.</div></div><div><h3>Result</h3><div>The change in Plaque Index (PI), Gingival Index (GI), Probing Pocket Depth (PPD), and Clinical Attachment Level (CAL) from baseline to 1 month and from baseline to 3 months was significantly higher in the SRP + OT group (<em>p</em> < 0.001). Reduction in the microbial count of <em>Porphyromonas gingivalis</em> (Keystone pathogen) (Mean difference = −0.70, <em>p</em> < 0.001) and <em>Tannerella forsythia</em> (−0.51, <em>p</em> < 0.001), whereas <strong>SRP + aPDT provided superior suppression</strong> for <em>Fusobacterium nucleatum</em> (−0.76, <em>p</em> < 0.001) and <em>Prevotella intermedia</em> (0.40, <em>p</em> < 0.001). No meaningful difference was observed between the two adjuncts for <em>Treponema denticola</em> (<em>p</em> = 0.994).</div></div><div><h3>Conclusion</h3><div>All treatment modalities resulted in significant improvements in all the parameters over time. However, SRP + Ozone Therapy consistently achieved the improvement across all parameters, when compared to SRP alone or SRP with aPDT.</div></div>","PeriodicalId":16609,"journal":{"name":"Journal of oral biology and craniofacial research","volume":"16 2","pages":"Article 101393"},"PeriodicalIF":0.0,"publicationDate":"2026-01-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145957725","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Synergistic effects of zinc oxide and ellagic acid on macrophage infiltration, angiogenesis, and collagen deposition in excisional wounds healing 氧化锌和鞣花酸对切除伤口愈合中巨噬细胞浸润、血管生成和胶原沉积的协同作用

Q1 Medicine

Journal of oral biology and craniofacial research

Pub Date : 2026-01-13 DOI: 10.1016/j.jobcr.2026.01.002

Intan Nirwana , Michelle Fidelia Alexandra , Tarissa Balqis Nuraida , Ahmad Thariq Bermani , Yasmin Shahaniz , Devi Rianti , Titien Hary Agustantina , Anita Yuliati , Khairul Annuar Shariff , Meircurius Dwi Condro Surboyo

Objectives

The combination of zinc oxide (ZnO) and ellagic acid (EA) in wound dressings offers synergistic benefits for wound healing due to their complementary antimicrobial, antioxidant, anti-inflammatory, and tissue regenerative properties. This study aimed to evaluate the effects of ZnO-EA dressing on macrophage infiltration, angiogenesis, and collagen density in excisional wounds on days 3 and 7 post-treatment.

Materials and methods

This in vivo posttest-only experimental study involved twenty Rattus norvegicus with excisional dorsal wounds, randomly assigned to two groups: a control group receiving ZnO dressing and a treatment group receiving ZnO-EA dressing. Each group was evaluated at day 3 and day 7, resulting in four observation subgroups. Tissue samples were collected to assess macrophage infiltration and angiogenesis using Hematoxylin and Eosin staining, and collagen density using Masson's Trichrome staining. Histological evaluation was performed under a light microscope at 400× magnification.

Results

Treatment with ZnO-EA resulted in significant increase in macrophages infiltration, the number of newly formed blood vessels, and collagen density in the treatment group compared to the ZnO group on both days 3 and 7 (p < 0.05).

Conclusion

The application of a ZnO wound dressing enriched with EA significantly enhances macrophage infiltration, angiogenesis, and collagen deposition during the wound healing process.

目的将氧化锌（ZnO）和鞣花酸（EA）结合在伤口敷料中，具有抗菌、抗氧化、抗炎和组织再生的协同作用。本研究旨在评价ZnO-EA敷料在治疗后第3天和第7天对切除创面巨噬细胞浸润、血管生成和胶原蛋白密度的影响。材料与方法本实验选取20只背部切除创面的褐家鼠，随机分为两组：对照组和治疗组分别采用ZnO- ea敷料。每组在第3天和第7天进行评估，形成4个观察亚组。收集组织样本，用苏木精和伊红染色评估巨噬细胞浸润和血管生成，用马松三色染色评估胶原蛋白密度。光镜下400倍放大进行组织学观察。结果与ZnO组相比，ZnO- ea治疗组在第3天和第7天巨噬细胞浸润、新生血管数量和胶原蛋白密度均显著增加（p < 0.05）。结论添加EA的氧化锌创面敷料可显著增强创面愈合过程中巨噬细胞的浸润、血管生成和胶原的沉积。

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引用次数: 0