Journal of oral biology and craniofacial research最新文献

{"title":"Three-dimensional finite element analysis of stress distribution on different complex macro designs in commercially available implants: An in-vitro study","authors":"Saranya V ,&nbsp;Mervin Harris ,&nbsp;Silpa Abraham ,&nbsp;Ramanarayanan Venkitachalam ,&nbsp;Shiv Shankar Nair ,&nbsp;Anil Mathew","doi":"10.1016/j.jobcr.2024.10.003","DOIUrl":"10.1016/j.jobcr.2024.10.003","url":null,"abstract":"<div><h3>Objective</h3><div>This study aimed to investigate the effects of different commercially available complex implant macro designs on stress distributions using Finite element analysis. The experiment is done under varying simulated bone conditions to provide reference for clinical application.</div></div><div><h3>Materials and methods</h3><div>The study employed the Finite Element Analysis (FEA) method to compare four commercially available complex implant macro designs on a Computer-Aided Design (CAD) model of a maxillary bone segment. The three-dimensional geometrical model of the implants was reconstructed from computed tomography (CT)-slices in Digital Imaging and Communications in Medicine (DICOM) format and contact condition between the implant and the bone was considered as ‘Bonded’, implying perfect osseointegration. All materials used in the models were assumed to be isotropic, homogeneous, and linearly elastic. The Finite element simulations employed load of 400 N under both axial and non-axial conditions Stresses were analysed under different bone conditions.</div></div><div><h3>Results</h3><div>Average values of von Mises stresses were used for comparing stress levels between implant designs. There was a definite increase in the equivalent stress values from higher density(D1)to lower density (D4) bone conditions for all implants. The percentage of increase ranged from 23.63 to 49.39 on axial loading and 20.39 to 57.19 when subjected to non-axial loading. The equivalent stress values resulted from non-axial loading were 1.78–2.94 times higher than that of axial loading for all implants under all bone densities. Among the complex designs Equinox Myriad Plus implant exhibited the least stress under axial loading (12.749–19.046 MPa) and (37.462–49.217 MPa) for non-axial loading. The stress on the crestal module was higher (1.49–2.99 times) than the overall stress on the implant regardless of the loading direction or bone conditions.</div></div><div><h3>Conclusions</h3><div>Data from the present study shows Equinox Myriad Plus implant generating the least equivalent stress and this can be taken as indicator in the biomechanical performance of the design.</div></div>","PeriodicalId":16609,"journal":{"name":"Journal of oral biology and craniofacial research","volume":"14 6","pages":"Pages 761-766"},"PeriodicalIF":0.0,"publicationDate":"2024-10-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142528187","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of different agents on preload force of dental implants with bio high-performance poly-ether-ether-ketone abutments","authors":"Sabina Mary Paul,&nbsp;Kuttae Viswanathan Anitha,&nbsp;Muthukumar Balasubramaniam","doi":"10.1016/j.jobcr.2024.10.004","DOIUrl":"10.1016/j.jobcr.2024.10.004","url":null,"abstract":"<div><h3>Purpose</h3><div>This study evaluated the influence of different agents such as blood, artificial saliva, and normal saline on preload force of dental implants with bio-high-performance poly-ether-ether-ketone (Bio-HPP) abutments to determine its effect on screw loosening.</div></div><div><h3>Methods</h3><div>Forty (N = 40) Grade 5 titanium dental implant analog (GM Implant Analog; Neodent, Straumann) with Bio-HPP poly ether-ether ketone (PEEK) abutment and titanium screw was used in the study. The samples were embedded in acrylic split mold. In the control Group C, no agent was added. In the other three groups, blood (B), normal saline (N) and saliva (S) was added in the access cavity of the samples. A sequential torque of 15 Ncm, 20 Ncm, 25 Ncm, 30 Ncm up to 35 Ncm was applied with a digital torque meter (Eclatorq, model: SD-05bn, range:2.5–50 Ncm, torque accuracy: ± 2%cw). Samples were subjected to thermomechanical cyclic loading at 5–55⁰ Celsius for 1000 cycles (Chewing simulator, CS 4.4) to simulate six months of clinical service. Preload was measured as reverse torque value (RTV). Raw data in the form of mean ± standard deviation was documented and subjected to statistical analysis. A one-way ANOVA was performed to contrast the groups. Tukey HSD test was used to determine the multiple comparison assessment (<em>P</em> &lt; 0. 05).</div></div><div><h3>Results</h3><div>A mean reverse torque value of 35 Ncm ±0.00 was observed in both control and in groups exposed to normal saline (<em>P &gt;</em>.05). Measurements of 33.4 Ncm ±2.51 and 34.8 Ncm ±0.40 were found when exposed to blood and artificial saliva in order (<em>P</em> &lt; .05). When compared with control, exposure to blood showed significant variation in preload (<em>P</em> = .03).</div></div><div><h3>Conclusion</h3><div>A significant reduction in reverse torque force was observed when titanium implants and Bio-HPP abutments were exposed to blood, suggesting a potential risk of screw loosening (P &lt; .05). In contrast, minimal decrease and no significant change in preload were noted with exposure to saliva and normal saline (P &gt; .05).</div></div>","PeriodicalId":16609,"journal":{"name":"Journal of oral biology and craniofacial research","volume":"14 6","pages":"Pages 756-760"},"PeriodicalIF":0.0,"publicationDate":"2024-10-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142446644","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The relationship of tooth shade and skin tone and its influence on smile attractiveness in native South Indians: A web-based cross sectional survey","authors":"Hrudi Sundar Sahoo,&nbsp;Aishwarya Balasubramanian","doi":"10.1016/j.jobcr.2024.10.005","DOIUrl":"10.1016/j.jobcr.2024.10.005","url":null,"abstract":"<div><h3>Objectives</h3><div>This study aimed to investigate the influence of tooth shade and skin tone on smile attractiveness among native South Indians. The primary research question was whether there is a significant relationship between these variables and perceived smile attractiveness.</div></div><div><h3>Materials and methods</h3><div>A web-based cross-sectional survey was conducted with approval from the Institutional Review Board of (Thai Moogambigai Dental College and Hospital, Chennai). Standardized smile photographs of two South Indian models (one male and one female) were digitally modified to display four different tooth shades and four different skin tones, resulting in 32 images. These images were incorporated into a Google Form along with a questionnaire and a Visual Analog Scale (VAS) for attractiveness rating. The survey was distributed to 1200 participants, including both dental professionals and the general population, with 1000 valid responses recorded. Statistical analysis was performed using IBM SPSS Statistics, employing parametric tests to evaluate the data.</div></div><div><h3>Results</h3><div>The study found that lighter tooth shades were consistently rated higher in attractiveness for both genders. Lighter tooth shades such as FS1T1 and FS2T1 scored means of 6.88 and 7.27 respectively for females, while darker shades like FS1T4 scored lower with a mean of 4.95. Similarly, males showed a preference for lighter tooth shades with MS1T1 and MS2T1 scoring means of 5.57 and 5.78 respectively compared to darker shades like MS1T4 with a mean of 3.63. Significant differences were noted across age groups and genders, with younger participants and females showing a stronger preference for lighter tooth shades.</div></div><div><h3>Conclusions</h3><div>The study concludes that both tooth shade and skin tone significantly influence smile attractiveness, with a clear preference for lighter tooth shades among the surveyed population. These findings suggest the importance of considering these factors in aesthetic dental treatments to enhance patient satisfaction and achieve optimal results.</div></div><div><h3>Clinical relevance</h3><div>The results underscore the necessity for dental practitioners to take into account both tooth shade and skin tone when planning aesthetic dental treatments. This approach will help in achieving a more harmonious and natural appearance, ultimately improving patient satisfaction with the treatment outcomes. Future research should continue to explore the cultural and individual factors that contribute to these preferences in dental aesthetics.</div></div>","PeriodicalId":16609,"journal":{"name":"Journal of oral biology and craniofacial research","volume":"14 6","pages":"Pages 746-750"},"PeriodicalIF":0.0,"publicationDate":"2024-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142442170","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A comparative evaluation of the antimicrobial efficacy of Chlorhexidine and Chlorine dioxide on self-ligating brackets contaminated with Streptococcus mutans biofilm- An In vitro study","authors":"Ashish Kumar Singh ,&nbsp;Yash Salkar ,&nbsp;Puneet Batra ,&nbsp;Garima Arora ,&nbsp;Shakila Mahesh","doi":"10.1016/j.jobcr.2024.10.001","DOIUrl":"10.1016/j.jobcr.2024.10.001","url":null,"abstract":"<div><h3>Objective</h3><div>To evaluate and compare antimicrobial efficacy of Chlorhexidine and Chlorine dioxide mouthwashes on <em>S</em>.<em>mutans</em> biofilm created on metal and ceramic self-ligating brackets.</div></div><div><h3>Materials and methods</h3><div>A total of 162 metal and ceramic self-ligating brackets (3M™ SmartClip™ &amp; Clarity SL™) were randomly divided into 3 groups and 2 subgroups. Standard procedures were followed to coat all brackets with <em>S</em>.<em>mutans</em> biofilm. The biofilms were cultivated which were then subjected to the effects of the mouthwashes. Quantitative assessment was carried out by comparing the number of viable colonies of <em>S</em>.<em>mutans.</em> A Mann-Whitney <em>U</em> test was used to compare the data between the experimental and control groups. (<em>p</em> &lt; 0.05).</div></div><div><h3>Result</h3><div>When compared to untreated controls the antimicrobial efficacy of Chlorhexidine Digluconate and Chlorine Dioxide mouthwashes was found to be statistically significant (<em>p</em> = 0.00). The comparison between Chlorhexidine digluconate and Chlorine dioxide mouthwashes was not statistically significant in Ceramic self-ligating group (<em>p</em> = 0.502) and statistically significant in Metal self-ligating group (<em>p</em> = 0.001)</div></div><div><h3>Conclusion</h3><div><em>S mutans</em> colonies on metal and ceramic self-ligating brackets can be reduced effectively by Chlorhexidine digluconate and Chlorine dioxide mouthwashes. Chlorhexidine digluconate more effective for metal bracket group. Both mouthwashes had comparable antimicrobial effectiveness, with the difference in the number of viable colonies following exposure for ceramic bracket groups.</div></div>","PeriodicalId":16609,"journal":{"name":"Journal of oral biology and craniofacial research","volume":"14 6","pages":"Pages 751-755"},"PeriodicalIF":0.0,"publicationDate":"2024-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142442172","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of ABO phenotype, rhesus factor, platelet count and hemoglobin level with oral hygiene status and severity of chronic periodontitis","authors":"Mohd Aamir Khan ,&nbsp;Nand Lal ,&nbsp;Tulika Chandra ,&nbsp;Wahid Ali ,&nbsp;Hira Ismail","doi":"10.1016/j.jobcr.2024.09.015","DOIUrl":"10.1016/j.jobcr.2024.09.015","url":null,"abstract":"<div><h3>Background</h3><div>The development of periodontal diseases has multifactorial causes including genetic factors. Limited investigations have been conducted to explore the association between ABO blood groups and the development and progression of periodontal diseases.</div></div><div><h3>Aim</h3><div>To evaluate and assess the association of ABO Phenotype and Rhesus factor with oral hygiene status, severity of chronic periodontitis and blood parameters like hemoglobin level and Platelet count in localized and generalized chronic periodontitis.</div></div><div><h3>Material and methods</h3><div>Study was carried out on 100 patients, out of which 80 patients of Generalized Chronic Periodontitis and 20 patients of Localized Chronic Periodontitis. Patients were categorized into Mild, Moderate and Severe Periodontitis.</div></div><div><h3>Result</h3><div>A highly significant association was found between severity of periodontitis and blood groups with blood group B and O were found to be at a greater risk to develop moderate to severe form of chronic periodontitis. Also subjects with blood group B and O showed worst oral hygiene among all the blood groups. Also patients suffering from chronic periodontitis showed a general trend towards lower limit of both hemoglobin level and platelet.</div></div><div><h3>Conclusion</h3><div>Genetic factors such as ABO blood group antigens may act as a risk influencer that plays a role in progression and severity of the chronic periodontitis, with blood group B and O being worst affected. Another observation was that a long standing case of chronic periodontitis can lead to anemia thus having systemic implications.</div></div>","PeriodicalId":16609,"journal":{"name":"Journal of oral biology and craniofacial research","volume":"14 6","pages":"Pages 730-734"},"PeriodicalIF":0.0,"publicationDate":"2024-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142437857","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fluoride effect on renal and hepatic functions: A comprehensive decade review of In vitro and In vivo studies","authors":"Sirigala Lavanya ,&nbsp;Kasirajan Hema Shree MDS ,&nbsp;Prathiba Ramani","doi":"10.1016/j.jobcr.2024.10.002","DOIUrl":"10.1016/j.jobcr.2024.10.002","url":null,"abstract":"<div><h3>Background</h3><div>This systematic review evaluates the toxicological effects of exposure to fluoride on renal and hepatic functioning. It compiles both in vitro &amp; in vivo studies across the last decade. By highlighting the potential health risks, the review aims to raise awareness and encourage a more attentive approach to fluoride use and exposure, instilling a sense of concern and vigilance in the audience.</div></div><div><h3>Methodology</h3><div>A thorough literature search covered relevant studies from 2013 to 2023, both experimental (in vitro) and animal (in vivo) research. The data extraction process focused on critical aspects such as sample size, methodologies used, key findings, and conclusions regarding fluoride's impact on kidney and liver functions. The review also includes a detailed analysis of gene expression, KEGG pathways, and STRING analysis, further enhancing the reliability of the results.</div></div><div><h3>Results</h3><div>Significant renal and liver damage were demonstrated in animal models exposed to high fluoride doses for long duration. Ferulic acid was found to mitigate fluoride-induced oxidative damage. The combined mean difference across studies was 6.52 [-5.22, 18.26], indicating high heterogeneity, which reflects diverse methodologies and findings. Notably, epigenetic and immune system impacts were underscored, with gene analysis identifying several genes involved in oxidative stress response, apoptosis, and inflammation pathways.</div></div><div><h3>Conclusion</h3><div>The findings emphasize the substantial evidence of its harmful effects on renal and liver functions at high exposure levels. Some studies indicate minimal impact, others demonstrate significant organ damage. The results underline the necessity for continued research to establish safe fluoride exposure limits and comprehend the mechanisms underlying its toxicity.</div></div>","PeriodicalId":16609,"journal":{"name":"Journal of oral biology and craniofacial research","volume":"14 6","pages":"Pages 735-745"},"PeriodicalIF":0.0,"publicationDate":"2024-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142437858","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hypertension and other etiological risk factors associated with the sublingual varices: A systematic review and meta-analysis","authors":"Anju James ,&nbsp;Chandrashekar Janakiram ,&nbsp;Vijay S. Kumar","doi":"10.1016/j.jobcr.2024.09.014","DOIUrl":"10.1016/j.jobcr.2024.09.014","url":null,"abstract":"<div><h3>Objective</h3><div>This review assesses the association between hypertension and other etiological risk factors associated with sublingual varices.</div></div><div><h3>Introduction</h3><div>Hypertension, smoking, type 2 diabetes, cardiovascular disease, and denture-wearing are risk indicators for sublingual varices. A better understanding of the potential risk factors associated with sublingual varices can assist dental clinicians in identifying underlying systemic conditions that require timely and appropriate management.</div></div><div><h3>Methods</h3><div>The search strategy aimed to retrieve both published and unpublished literature. The databases searched included PubMed, Scopus, Google Scholar, EBSCO-APA PsycInfo, Web of Science, CINAHL, ProQuest, and Shodhganga. All retrieved citations underwent screening to assess compatibility with the inclusion criteria. The methodological validity of the included studies was critically appraised using the JBI critical appraisal tool. Quantitative data were aggregated and analyzed through a meta-analysis. For dichotomous data, the effect size was presented as odds ratios.</div></div><div><h3>Results</h3><div>Among the nine studies included in this review, eight were cross-sectional, and one was a case-control study. The total number of participants in all nine studies was 3,854, with individual survey participant numbers ranging from 151 to 1008. The methodological quality of all included studies was good. Risk factors such as history of smoking [OR 2.59 (95 % CI 1.39, 4.81), p = 0.003], hypertension [OR 4.99 (95 % CI 1.86, 13.39), p = 0.001], cardiovascular diseases [OR 6.01 (95 % CI 4.15, 8.70), p &lt; 0.001] and denture wearing [OR 2.64 (95 % CI 1.53, 4.53), p &lt; 0.001] were significantly associated with sublingual varices.</div></div><div><h3>Conclusion</h3><div>Hypertension, cardiovascular disease, history of smoking and denture wearing. are the risk factors associated with sublingual varices.</div></div><div><h3>Systematic review registration number</h3><div>PROSPERO CRD42023396643.</div></div>","PeriodicalId":16609,"journal":{"name":"Journal of oral biology and craniofacial research","volume":"14 6","pages":"Pages 720-729"},"PeriodicalIF":0.0,"publicationDate":"2024-10-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142425384","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Investigation of genetic polymorphisms in genes encoding growth factors and dental pulp calcification in orthodontic patients","authors":"Sandra Regina Santos Meyfarth ,&nbsp;Iago Ramirez ,&nbsp;Alice Corrêa Silva-Sousa ,&nbsp;Peter Proff ,&nbsp;Marilisa Carneiro Leão Gabardo ,&nbsp;Manoel Damião Sousa-Neto ,&nbsp;Flares Baratto-Filho ,&nbsp;Erika Calvano Küchler ,&nbsp;Leonardo Santos Antunes ,&nbsp;Christian Kirschneck","doi":"10.1016/j.jobcr.2024.09.013","DOIUrl":"10.1016/j.jobcr.2024.09.013","url":null,"abstract":"<div><h3>Background and objectives</h3><div>Pulp calcification is associated with many factors and triggers, including individual genetic predisposition and orthodontic forces. This study aimed to investigate whether genetic polymorphisms in <em>epidermal growth factor (EGF), epidermal growth factor receptor (EGFR1), transforming growth factor-beta 1 (TGFβ1), and transforming growth factor-beta receptor 2 (TGFβR2)</em> are associated with a risk of dental pulp calcifications in orthodontic patients.</div></div><div><h3>Materials and methods</h3><div>Digital orthopantomography (OPG) and genomic DNA from 132 patients were analyzed in this cross-sectional study. Pulp calcification was observed in the maxillary and mandibular first molars. Genomic DNA extracted from saliva cells was used to genotype eight genetic polymorphisms using real-time polymerase chain reaction: <em>EGF</em> (rs2237051 and rs4444903), <em>EGFR</em> (rs2227983 and rs763317), <em>TGFβ1</em> (rs1800469 and rs4803455), and <em>TGFβR2</em> (rs3087465 and rs764522). The association between pulp calcification and genetic polymorphisms was analyzed using allelic and genotypic distributions, and haplotype frequencies (<em>P</em> &lt; 0.05).</div></div><div><h3>Results</h3><div>The prevalence of pulp calcification was 42.4 % in 490 molars. Genotypic analysis and allelic distribution showed no statistically significant association between the evaluated growth factors and molar calcification (<em>P</em> &gt; 0.05). No haplotype combinations showed a statistically significant difference (<em>P</em> &gt; 0.05).</div></div><div><h3>Conclusion</h3><div>The genetic polymorphisms investigated were not associated with dental pulp calcification in orthodontic patients. Further studies should investigate other polymorphisms in genes encoding growth factors.</div></div>","PeriodicalId":16609,"journal":{"name":"Journal of oral biology and craniofacial research","volume":"14 6","pages":"Pages 712-719"},"PeriodicalIF":0.0,"publicationDate":"2024-10-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142425383","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of FokI (rs2228570) and BglI (rs739837) polymorphisms in VDR gene on permanent tooth eruption: A cross-sectional study","authors":"Caio Luiz Bitencourt Reis ,&nbsp;Kelem Cristina Cambraia Caproni Guerra ,&nbsp;Mariane Carolina Faria Barbosa ,&nbsp;Fabricio Fernandes Ferreira ,&nbsp;Daniela Coelho de Lima ,&nbsp;Raquel Assed Bezerra Segato ,&nbsp;Ana Cláudia Pedreira de Almeida ,&nbsp;Mirian Aiko Nakane Matsumoto ,&nbsp;Flares Baratto Filho ,&nbsp;Maria Angélica Hueb de Menezes ,&nbsp;Erika Calvano Küchler ,&nbsp;Daniela Silva Barroso de Oliveira","doi":"10.1016/j.jobcr.2024.09.012","DOIUrl":"10.1016/j.jobcr.2024.09.012","url":null,"abstract":"<div><h3>Introduction</h3><div>Genetic polymorphisms who disturb the mineral homeostasis during tooth development and eruption are candidate to clarify the molecular mechanisms involved in changes in the tooth eruption chronology. In this study, we evaluate whether the FokI (rs2228570) and BglI (rs739837) polymorphisms in the <em>Vitamin D receptor (VDR)</em> gene are associated with changes in the chronology of eruption of permanent teeth.</div></div><div><h3>Material &amp; method</h3><div>This cross-sectional study randomly included 353 biologically unrelated children, both sexes, without systemic impairment or syndromes and history of trauma during the primary dentition. One operator perform the oral clinical examination. The tooth was considered erupted if there was a visible minimum of any tooth surface emerging from the mucosa. Genomic DNA was extracted from buccal epithelial cells from saliva samples. Genotyping was performed by Real-Time Polymerase Chain Reactions using TaqMan® technology. The average of the total number of erupted permanent teeth between the genotypes was compared by the Mann-Whitney test and multivariate Generalized Linear Models (GLM) (α = 5 %). β values with Confidence Interval (CI) 95 % were calculated.</div></div><div><h3>Results</h3><div>The heterozygous adenine-guanine genotype of the FokI significantly decreases the number of erupted permanent teeth (β = −1.15; CI 95 % = −2.22 to −0.07; p = 0.036). In the stratified analysis for maxillary and mandibular teeth, this genotype was associated with a decrease in the number of erupted maxillary permanent teeth (β = −0.65; CI 95 % = −1.22 to −0.09; p = 0.023). BglI was not associated with permanent teeth eruption.</div></div><div><h3>Conclusion</h3><div>The FokI, but not BglI, in the <em>VDR</em> may delay the eruption of permanent teeth.</div></div>","PeriodicalId":16609,"journal":{"name":"Journal of oral biology and craniofacial research","volume":"14 6","pages":"Pages 700-705"},"PeriodicalIF":0.0,"publicationDate":"2024-09-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142326362","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hydroxyapatite synthesis and characterization from marine sources: A comparative study","authors":"Krishna Meghal Balabadra,&nbsp;Suganya Panneer Selvam,&nbsp;Ramya Ramadoss,&nbsp;Sandhya Sundar","doi":"10.1016/j.jobcr.2024.09.009","DOIUrl":"10.1016/j.jobcr.2024.09.009","url":null,"abstract":"<div><h3>Background</h3><div>Hydroxyapatite (HAP) is a biocompatible material widely used in biomedical applications. Recent studies have explored various marine sources for HAP synthesis, demonstrating its potential for diverse applications.</div></div><div><h3>Objective</h3><div>This study aims to compare the characteristics of hydroxyapatite synthesized from sea shells and fish bones, specifically from the shells of <em>Scylla olivacea</em> (orange mud crab) and bones of <em>Eleutheronema tetradactylum</em> (fourfinger threadfin).</div></div><div><h3>Materials &amp; methods</h3><div>HAP was synthesized from <em>Scylla olivacea</em> shells and <em>Eleutheronema tetradactylum</em> bones. The synthesized HAP underwent comprehensive characterization, including scanning electron microscopy (SEM) for structural analysis, hemocompatibility testing, antibacterial assays, and energy-dispersive X-ray spectroscopy (EDS) analysis.</div></div><div><h3>Results</h3><div>SEM revealed a complex structure of HAP with a clustered arrangement and biofilm-like features. HAP derived from crab shells exhibited superior structural properties compared to that from fish bones. Both sources demonstrated good hemocompatibility, essential for biomedical applications. The antibacterial assays indicated effective antibacterial properties for both HAP sources, with crab shell-derived HAP showing slightly better performance. EDS analysis confirmed the presence of key elements necessary for HAP, with a consistent composition in both sources.</div></div><div><h3>Conclusion</h3><div>Our study concludes that hydroxyapatite derived from <em>Scylla olivacea</em> shells exhibits superior properties compared to that from <em>Eleutheronema tetradactylum</em> bones. This research establishes a precedent for future investigations into other marine species, thereby broadening the scope and potential of hydroxyapatite synthesis from natural sources.</div></div>","PeriodicalId":16609,"journal":{"name":"Journal of oral biology and craniofacial research","volume":"14 6","pages":"Pages 706-711"},"PeriodicalIF":0.0,"publicationDate":"2024-09-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142326363","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}