Journal of oral biology and craniofacial research最新文献_第4页

Evaluating the role of inflammatory biomarkers as a diagnostic tool in peri-implantitis

Q1 Medicine

Journal of oral biology and craniofacial research

Pub Date : 2025-02-09 DOI: 10.1016/j.jobcr.2025.01.015

Ayan Saxena , Pavitra Kumar Rastogi , Nand Lal , Umesh Pratap Verma , Rameshwari Singhal , Md. Kaleem Ahmad

Background

Most studies have analyzed the presence of cytokines in Gingival crevicular fluid (GCF) in different periodontal diseases, but very limited studies have been conducted on Peri-implant crevicular fluid (PICF) in peri-implantitis.

Aim

The present study was conceptualized to explore the levels of Interleukin (IL)-1β and Interleukin (IL)-6 as a diagnostic marker in peri-implantitis.

Materials and methods

A total of 40 patients each having at least one dental implant were enrolled in the study. Clinical parameters were recorded around each implant and tooth nearest to it. Gingival crevicular fluid (GCF)/Peri-implant crevicular fluid (PICF) was collected to evaluate the concentration of IL‐1β and IL‐6. Conservative treatment was performed in peri-implantitis cases, 3 months after treatment their clinical parameters, IL-1β and IL-6 levels were recorded and compared with their pre-treatment values.

Results

Clinical parameters like Modified Plaque Index (MPI), Modified Bleeding Index (MBI) and Probing Pocket Depth (PPD) were statistically significantly higher in the peri-implantitis group as compared to the healthy implant group and healthy teeth group. IL-1β and IL-6 levels were also statistically significantly higher in the peri-implantitis group in comparison to healthy implants and healthy teeth group.

Conclusion

The study concludes that biomarkers in PICF can be used as a diagnostic tool to supplement the diagnosis of peri-implantitis along with the use of clinical parameters to make an early diagnosis of peri-implantitis possible.

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引用次数: 0

Effect of cryotherapy, laser therapy and intraligamentary dexamethasone injection on post-treatment pain after single visit RCT–A double-blinded, randomized placebo-controlled trial

Q1 Medicine

Journal of oral biology and craniofacial research

Pub Date : 2025-02-09 DOI: 10.1016/j.jobcr.2025.01.005

Dr Sana Fatima , Dr Sonali Taneja , Dr Vivek Aggarwal , Dr Akriti Dheer , Dr Punya Taneja

Aim

This study designed to evaluate the effect of adjuvant therapies on the intensity of post-treatment pain after single-visit RCT in molars with symptomatic apical periodontitis.

Method

ology: This trial was reported according PRIRATE 2020 guidelines and registered with CTRI/2019/03/018,153.100 patients diagnosed with symptomatic apical periodontitis with a preoperative pain allocated to 4 groups,Group-1: placebo,Group-2:Intraligamentary injection of dexamethasone, Group-3:cryotherapy, Group-4: laser therapy. Patients were instructed to record postoperative pain intensity and intake of analgesics after 6,12,24,48 & 72 h. Intergroup pain intensity was tested by using the Kruskal-Wallis test. The need for painkillers between groups was analyzed using Chi-square test. P value of <0.05 was considered statistically significant.

Results: Patients in the placebo group exhibited higher intensity. Group 3 showed lesser pain at all-time intervals.

Conclusion

All the adjuvant pain management therapies reduced the intensity of postoperative pain and the frequency of intake of analgesics.

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引用次数: 0

Advanced deep learning techniques for recognition of dental implants

Q1 Medicine

Journal of oral biology and craniofacial research

Pub Date : 2025-02-08 DOI: 10.1016/j.jobcr.2025.01.016

Veena Benakatti , Ramesh P. Nayakar , Mallikarjun Anandhalli , Rohit sukhasare

Background

Dental implants are the most accepted prosthetic alternative for missing teeth. With growing demands, several manufacturers have entered the market and produce a variety of implant brands creating a challenge for clinicians to identify the implant when the necessity arises. Currently, radiographs are the only tools for implant identification which is inherently a complex process, hence the need for implant identification technique. Artificial intelligence capable of analysing images in a radiograph and predicting implant type is an efficient tool. The study evaluated an advanced deep learning technique, DEtection TRanformer for implant identification.

Methods

A transformer-based deep learning technique, DEtection TRanformer was trained to identify implants in radiographs. A dataset of 1138 images consisting of five implant types captured from periapical and panoramic radiographs was chosen for the study. After augmentation, a dataset of 1744 images was secured and then split into training, validation and test datasets for the model. The model was trained and evaluated for its performance.

Results

The model achieved an overall precision of 0.83 and a recall score of 0.89. The model achieved an F1-score of 0.82 indicating a strong balance between recall and precision. The Precision-Recall Curve, with an AUC of 0.96, showed that the model performed well across various thresholds. The training and validation graphs showed a consistent decrease in the loss functions across classes.

Conclusion

The model showed high performance on the training data, though it faced challenges with unseen validation data. High precision, recall and F1 score indicate the model's potential for implant identification. Optimizing this model for a balance between accuracy and efficiency will be necessary for real-time medical imaging applications.

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引用次数: 0

Pharyngeal airway dimensions and adipose distribution in the minipig 小型猪咽部气道尺寸及脂肪分布。

Q1 Medicine

Journal of oral biology and craniofacial research

Pub Date : 2025-01-01 DOI: 10.1016/j.jobcr.2024.12.004

Doris H. Rosero Salazar , Riana Grewal , Anuj Vimawala , Daniel F. Leotta , Swati R. Levendovszky , Zi-Jun Liu

Objective

To evaluate the pharyngeal airway dimensions and regional pharyngeal adipose distribution in the young adult minipig model.

Materials and methods

Eight 7-8-months-old Yucatan minipigs, half male and female, were sedated and placed prone to scan the pharyngeal region. Magnetic resonance imaging (MRI) was performed using dynamic turbo-field echo (TFE)-sequence with respiratory gating and adipose-weighted sequence. Respiratory airflow velocity, pressure, and volume were also recorded. The sizes of velopharyngeal and oropharyngeal airway, and retroglossal areas were measured coronally during inspiration and expiration. The airway volumes from the nasal cavity to the retroglossal space were segmented, reconstructed, and evaluated in sagittal views. The adipose distribution in the tongue base, soft palate, pharyngeal wall, tongue body, and masseter muscle (reference) were segmented and measured in sagittal and coronal planes.

Results

The velopharyngeal and oropharyngeal areas were larger in inspiration than in expiration. These areas were also larger than that in the retroglossal space (p < 0.05). The nasal cavity showed a larger volume than that of the pharyngeal regions (p < 0.05). The adipose distribution was larger in the posterior region of the tongue base and anterior soft palate, both larger than the masseter muscle (p < 0.05).

Conclusion

The larger oropharyngeal dimensions and increased adipose distribution in the tongue base contribute to the functional morphology of the pharyngeal airway in the healthy minipig. These data provide the baseline for further analysis in enlarged and reduced tongue base minipig models.

目的：探讨成年小型猪模型咽部气道尺寸及咽部脂肪分布。材料与方法：8头7-8月龄的尤卡坦迷你猪，雌雄各占一半，镇静后俯卧位扫描咽区。磁共振成像（MRI）采用动态涡场回波（TFE）序列，呼吸门控和脂肪加权序列。同时记录呼吸气流速度、压力和体积。吸气和呼气时冠状测量腭咽、口咽气道及舌后区大小。从鼻腔到舌后间隙的气道体积被分割、重建，并在矢状位上评估。在矢状面和冠状面对舌基部、软腭、咽壁、舌体和咬肌（参考）的脂肪分布进行分割和测量。结果：吸气时腭咽和口咽区大于呼气时。结论：健康小型猪的口咽尺寸增大，舌底脂肪分布增加，有助于改善其咽道的功能形态。这些数据为进一步分析扩大和缩小舌基的迷你猪模型提供了基础。

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引用次数: 0

Comparative evaluation of remineralizing potential of four enamel remineralising agents using SEM-EDX – An in-vitro study

Q1 Medicine

Journal of oral biology and craniofacial research

Pub Date : 2025-01-01 DOI: 10.1016/j.jobcr.2025.01.006

R. Raj

Objective

Compare the remineralisation potential of four enamel remineralising agents on artificially demineralized enamel surface using Scanning electron microscopy- Energy dispersive x-ray.

Materials and methods

75 extracted maxillary and mandibular premolars coated with acid-resistant nail varnish, were stored in demineralising solution for 96 h to produce artificial caries lesions. The samples were divided into 5 groups (n = 15), Control (Demineralized- No treatment), Group I samples were treated with casein phosphoprotein-amorphous calcium phosphate (CPP-ACP), Group II with self-assembling peptide (SAP-14), Group III with tri-calcium phosphate (f-TCP) and Group IV with Bioactive glass (BAG), respectively. The pH cycling model was followed for 21 days. The samples were analysed via SEM-EDX (Carl Zeiss, Germany; Model: Merlin Compact) for qualitative assessment and quantitative analysis of calcium and phosphorous. The data were analysed for multiple group comparison using IBM SPSS version 20 with one-way ANOVA followed by a paired t-test.

Results

Calcium/Phosphorous ratio of all experimental groups; Group 1(1.92 ± .17), Group 2 (1.98 ± .16), Group 3 (1.81 ± .03), Group 4 (1.75 ± .08) was statistically different (p < 0.0005) from Control; while there was no difference between Group I and Group II (p = 0.33).

Conclusion

All experimental groups showed comparable remineralising potential. Even though no statistically significant difference is seen between Group I and Group II, after correlating with surface analysis it was concluded that Group II showed the greatest remineralising potential.

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引用次数: 0

Dental implant placement accuracy with robotic surgery compared to free-hand, static and dynamic computer assisted techniques: Systematic review and meta-analysis 与徒手、静态和动态计算机辅助技术相比，机器人手术的牙种植体放置准确性：系统回顾和荟萃分析。

Q1 Medicine

Journal of oral biology and craniofacial research

Pub Date : 2025-01-01 DOI: 10.1016/j.jobcr.2024.12.005

Hariram Sankar , M. Shalini , Anjana Rajagopalan , Satish Gupta , Amit Kumar , Rukhsar Shouket

Background

This systematic review and meta-analysis compared the accuracy of robotic-assisted dental implant placement (r-CAIS) with conventional freehand, static computer-assisted (s-CAIS), and dynamic computer-assisted (d-CAIS) techniques.

Methods

A comprehensive search was conducted in PubMed, Google Scholar, Semantic Scholar, and the Cochrane Library from January 2000 to January 2024. Studies meeting PICOST criteria, including clinical and in vitro studies, were included. Data on coronal, apical, and angular deviations were extracted for meta-analysis. The risk of bias (RoB) was assessed using the QUIN RoB and JBI RoB tools.

Results

A total of 134 models and 100 patients with edentulous and partially edentulous arches were included. Eight studies (four in vitro, four in vivo) were reviewed, demonstrating that r-CAIS offers superior accuracy compared to freehand, s-CAIS, and d-CAIS techniques. Among the studies, two in vitro and two in vivo studies had a low RoB, while others had a high RoB. The meta-analysis of five studies showed significant improvements in coronal, apical, and angular deviations with robotic systems.

Conclusion

Robotic-assisted systems showed greater accuracy than traditional non-robotic systems. However, this finding should be interpreted with caution due to the limited number of clinical studies and potential funding biases. Moreover, the high cost of robotic systems presents challenges for routine clinical implementation. Future research should focus on cost-effectiveness and seek broader clinical validation.

背景：本系统综述和荟萃分析比较了机器人辅助种植体植入（r-CAIS）与传统徒手、静态计算机辅助（s-CAIS）和动态计算机辅助（d-CAIS）技术的准确性。方法：综合检索2000年1月至2024年1月PubMed、谷歌Scholar、Semantic Scholar和Cochrane Library。符合PICOST标准的研究包括临床和体外研究。提取冠状、根尖和角度偏差数据进行meta分析。使用QUIN RoB和JBI RoB工具评估偏倚风险（RoB）。结果：共纳入134个模型和100例无牙和部分无牙弓患者。回顾了八项研究（四项体外研究，四项体内研究），表明与徒手、s-CAIS和d-CAIS技术相比，r-CAIS具有更高的准确性。在这些研究中，两项体外研究和两项体内研究的RoB较低，而其他研究的RoB较高。五项研究的荟萃分析显示，机器人系统在冠状、根尖和角度偏差方面有显著改善。结论：机器人辅助系统比传统的非机器人辅助系统具有更高的准确性。然而，由于临床研究数量有限和潜在的资金偏见，应该谨慎解释这一发现。此外，机器人系统的高成本对常规临床实施提出了挑战。未来的研究应侧重于成本效益，并寻求更广泛的临床验证。

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引用次数: 0

Evaluation of exo-long noncoding RNA MALAT1 in OSCC in comparison to dysplastic and normal: A cross-sectional study

Q1 Medicine

Journal of oral biology and craniofacial research

Pub Date : 2025-01-01 DOI: 10.1016/j.jobcr.2024.12.018

Ramya Sekar , Selvaraj Jayaraman , VishnuPriya Veeraraghavan , Kalaiselvi Krishnamoorthy , Shubhra Chauhan Aramanai , Sathan Raj Natarajan

Objective

This study explores the role of MALAT1 as a valuable target for creating minimally-invasive diagnostic methods and personalized treatments in the management of OSCC. It focuses on evaluating the role of exosomal MALAT1 in the progression of dysplasia to OSCC by influencing the PI3K/AKT pathway.

Method

This cross-sectional study evaluated MALAT1 expression and PI3K/AKT pathway components in exosomes derived from plasma samples of patients with various stages of oral dysplasia, OSCC and compared with normal. RNA concentration was estimated, real-time polymerase chain reaction (qPCR) was used for quantitative analysis. Gene expression levels of MALAT1, PI3K, AKT1, and PTEN were analysed and compared across groups using one way ANOVA and Post-hoc Tukey analysis was performed for pairwise comparisons to assess correlations between MALAT1 expression and PI3K/AKT pathway components.

Result

MALAT1 was found to be overexpressed in OSCC in comparison to normal, significantly (p < 0.001∗). There was no significant change in expression pattern of MALAT1 between dysplastic patients and normal, yet, significant association was found on corelation analysis between expression pattern of MALAT1 and PI3K/AKT/PTEN (p 0.001∗) among individuals of dysplasia and OSCC. As well pairwise comparisons of MALAT1 expression levels between all three stages of dysplasia showed significant association (p < 0.001∗).

Conclusion

MALAT1 stands out as a key player in the complex landscape of OSCC pathogenesis, impacting tumorigenesis, metastasis, and treatment outcomes through multifaceted molecular mechanisms. Continued research into MALAT1's regulatory roles and its interactions within the tumor microenvironment holds promise for uncovering novel therapeutic targets and biomarkers that could redefine the management of OSCC in the future.

{"title":"Evaluation of exo-long noncoding RNA MALAT1 in OSCC in comparison to dysplastic and normal: A cross-sectional study","authors":"Ramya Sekar , Selvaraj Jayaraman , VishnuPriya Veeraraghavan , Kalaiselvi Krishnamoorthy , Shubhra Chauhan Aramanai , Sathan Raj Natarajan","doi":"10.1016/j.jobcr.2024.12.018","DOIUrl":"10.1016/j.jobcr.2024.12.018","url":null,"abstract":"<div><h3>Objective</h3><div>This study explores the role of MALAT1 as a valuable target for creating minimally-invasive diagnostic methods and personalized treatments in the management of OSCC. It focuses on evaluating the role of exosomal MALAT1 in the progression of dysplasia to OSCC by influencing the PI3K/AKT pathway.</div></div><div><h3>Method</h3><div>This cross-sectional study evaluated MALAT1 expression and PI3K/AKT pathway components in exosomes derived from plasma samples of patients with various stages of oral dysplasia, OSCC and compared with normal. RNA concentration was estimated, real-time polymerase chain reaction (qPCR) was used for quantitative analysis. Gene expression levels of MALAT1, PI3K, AKT1, and PTEN were analysed and compared across groups using one way ANOVA and Post-hoc Tukey analysis was performed for pairwise comparisons to assess correlations between MALAT1 expression and PI3K/AKT pathway components.</div></div><div><h3>Result</h3><div>MALAT1 was found to be overexpressed in OSCC in comparison to normal, significantly (<em>p</em> < 0.001∗). There was no significant change in expression pattern of MALAT1 between dysplastic patients and normal, yet, significant association was found on corelation analysis between expression pattern of MALAT1 and PI3K/AKT/PTEN (<em>p</em> 0.001∗) among individuals of dysplasia and OSCC. As well pairwise comparisons of MALAT1 expression levels between all three stages of dysplasia showed significant association (<em>p</em> < 0.001∗).</div></div><div><h3>Conclusion</h3><div>MALAT1 stands out as a key player in the complex landscape of OSCC pathogenesis, impacting tumorigenesis, metastasis, and treatment outcomes through multifaceted molecular mechanisms. Continued research into MALAT1's regulatory roles and its interactions within the tumor microenvironment holds promise for uncovering novel therapeutic targets and biomarkers that could redefine the management of OSCC in the future.</div></div>","PeriodicalId":16609,"journal":{"name":"Journal of oral biology and craniofacial research","volume":"15 1","pages":"Pages 123-128"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11754077/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143029094","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Binaural auditory beats vs music of choice as audio distraction behaviour guidance technique among children: A randomized controlled trial

Q1 Medicine

Journal of oral biology and craniofacial research

Pub Date : 2025-01-01 DOI: 10.1016/j.jobcr.2024.12.019

Bhuvanesh N. Bhusari, Shivayogi M. Hugar, Niraj Gokhale, Shweta Kajjari, Sanika Karmarkar, Varunika Sahai

Background

Binaural beat is created by presenting two different pure-tone sine waves with less than a 30Hz difference dichotically. In dental settings, children listening to familiar music during treatments gain control over the anxiety caused by tools like the airotor or syringe, creating a comforting, familiar environment.

Aim

To evaluate and compare anxiety level during restorative treatment using No Music, Music of choice and Binaural Auditory Beats as Audio distraction behaviour guidance technique in children aged 6–12 years.

Methods

In-vivo, double-blind, three-arm, parallel-group randomized study was conducted in the department of pediatric and preventive dentistry where 75 participants were allocated into 3 groups. The teeth with Class I cavity in primary and permanent molars were prepared and restored. Anxiety was measured pre- and post-intervention using Pulse oximeter and Venham's picture test.

Results

Children who were treated with Binaural beats and Music of choice showed reduction in anxiety levels as indicated by lower anxiety scores in Venham picture test and pulse rate values as compared to the control group.

Conclusion

Binaural auditory beats and Music of choice can be used effectively as a non-invasive treatment modality to reduce anxiety in apprehensive pediatric patients.

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引用次数: 0

Evaluation of patient comfort and satisfaction after the surgical removal of mandibular impacted molars using a piezo-electric technique: A randomized double-blind clinical trial 使用压电技术去除下颌阻生磨牙后患者舒适度和满意度的评估：一项随机双盲临床试验。

Q1 Medicine

Journal of oral biology and craniofacial research

Pub Date : 2025-01-01 DOI: 10.1016/j.jobcr.2024.12.009

Khalid Zabin Alotaibi , Waleed Mohammed Al Rasheed , Jiingade Krishnojirao Dayashankara Rao , Abdulrahman Altwaijri , Gharam Mefleh Alharbi , Shatha saleh Aljaber

Introduction

This is a double clinical trial conducted to study the patient satisfaction and comfort during and after surgical removal of impacted mandibular 3rd molar using Piezo electric tips.

Material and methods

Two groups of 25 each [14 (56 %) males and 11 (44 %) females] and [18 (72 % males and 07 (28 %) females] represented the Rotary and Piezo groups respectively with bilateral impactions. one side of the patient is operated by piezo and the other side by rotary instrument after a gap of 2–3 week between the procedures. The variables considered are pain, swelling, trismus, patient satisfaction and comfort. The readings were taken on base line,3rd day,7th and 14th day.

Results

Descriptive statistical analysis was performed using means and standard deviations for continuous variables and percentages for categorical variables. The level of significance was set at p < 0.05. The surgery time taken was more in the Piezo group (26.96 ± 12.201) in comparison with the Rotary group (21.32 ± 12.786- (p = 0.011∗). Satisfaction was rated better in the Piezo group (3.18 ± 0.909 vs 2.88 ± 0.881) (p = 0.013∗). Tactile sensation was less in the Piezo group (1.24 ± 0.436) vs (2.28 ± 0.678) (p = 0.001). Less pain was reported in the piezo group patients and the difference between the two groups was statistically significant only during the third day follow up (p = 0.001).

Conclusion

The overall patient satisfaction and comfort was better in piezo in spite of longer duration of surgery. It provides better quality of life as the patients experienced less pain and the total number of analgesics taken is significantly less compared to rotary group.

简介：本研究是一项双临床试验，旨在研究使用压电尖牙拔除下颌阻生第三磨牙手术期间和术后患者的满意度和舒适度。材料与方法：双侧嵌塞的Rotary组和Piezo组各25例[男性14例（56%），女性11例（44%）]，男性18例（72%），女性07例（28%）]。手术间隔2-3周后，患者的一侧采用压电式手术，另一侧采用旋转式手术。考虑的变量包括疼痛、肿胀、牙关、患者满意度和舒适度。在基线、第3天、第7天和第14天取读数。结果：对连续变量采用均值和标准差，对分类变量采用百分比进行描述性统计分析。结论：尽管手术时间较长，但患者总体满意度和舒适度较好。与旋转组相比，它提供了更好的生活质量，因为患者经历了更少的疼痛，并且服用的镇痛药总数显着减少。

{"title":"Evaluation of patient comfort and satisfaction after the surgical removal of mandibular impacted molars using a piezo-electric technique: A randomized double-blind clinical trial","authors":"Khalid Zabin Alotaibi , Waleed Mohammed Al Rasheed , Jiingade Krishnojirao Dayashankara Rao , Abdulrahman Altwaijri , Gharam Mefleh Alharbi , Shatha saleh Aljaber","doi":"10.1016/j.jobcr.2024.12.009","DOIUrl":"10.1016/j.jobcr.2024.12.009","url":null,"abstract":"<div><h3>Introduction</h3><div>This is a double clinical trial conducted to study the patient satisfaction and comfort during and after surgical removal of impacted mandibular 3rd molar using Piezo electric tips.</div></div><div><h3>Material and methods</h3><div>Two groups of 25 each [14 (56 %) males and 11 (44 %) females] and [18 (72 % males and 07 (28 %) females] represented the Rotary and Piezo groups respectively with bilateral impactions. one side of the patient is operated by piezo and the other side by rotary instrument after a gap of 2–3 week between the procedures. The variables considered are pain, swelling, trismus, patient satisfaction and comfort. The readings were taken on base line,3rd day,7th and 14th day.</div></div><div><h3>Results</h3><div>Descriptive statistical analysis was performed using means and standard deviations for continuous variables and percentages for categorical variables. The level of significance was set at p < 0.05. The surgery time taken was more in the Piezo group (26.96 ± 12.201) in comparison with the Rotary group (21.32 ± 12.786- (p = 0.011∗). Satisfaction was rated better in the Piezo group (3.18 ± 0.909 vs 2.88 ± 0.881) (p = 0.013∗). Tactile sensation was less in the Piezo group (1.24 ± 0.436) vs (2.28 ± 0.678) (p = 0.001). Less pain was reported in the piezo group patients and the difference between the two groups was statistically significant only during the third day follow up (p = 0.001).</div></div><div><h3>Conclusion</h3><div>The overall patient satisfaction and comfort was better in piezo in spite of longer duration of surgery. It provides better quality of life as the patients experienced less pain and the total number of analgesics taken is significantly less compared to rotary group.</div></div>","PeriodicalId":16609,"journal":{"name":"Journal of oral biology and craniofacial research","volume":"15 1","pages":"Pages 108-112"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11732487/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142983881","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effect of nanoemulsion carbonated hydroxyapatite-statin administration on Acp 5 and Runx-2 expression during orthodontic relapse in rats

Q1 Medicine

Journal of oral biology and craniofacial research

Pub Date : 2025-01-01 DOI: 10.1016/j.jobcr.2024.12.013

Ananto Ali Alhasyimi , Niswati Fathmah Rosyida , Ika Dewi Ana

Background

Retention is an essential element of orthodontic treatment. In the past two decades, numerous biological treatments have been developed to alleviate orthodontic relapse. Pharmacologic bone modulation is a viable approach to mitigate relapse. The aim of this investigation was to determine whether administering nanoemulsion carbonated hydroxyapatite-statin (CHA-statin) would increase Runx-2 expression and decrease Acp 5 expression in rats experiencing experimental orthodontic relapse.

Materials & methods

Forty-eight rats (n = 48) were assigned to four groups: control, CHA, statin, and CHA-statin, with 12 rats in each group. A 30 g mesial traction was applied for 7 days via a closed-coil spring that connected the first maxillary molar to the maxillary incisor. To maintain the moved teeth, CHA, statin hydrogel, and nanoemulsion CHA-statin were administered intrasulcularly every 3 days for a period of 7 days. The removal of the devices facilitated the occurrence of relapse. The expression of Acp 5 and Runx-2 was evaluated using the immunohistochemistry method. The collected data were evaluated using analysis of variance and post hoc tests, with p < 0.05.

Results

A significant reduction in Acp 5-positive cells in the CHA-statin group was observed on days 7 and 14 of relapse movement compared with the other groups (p < 0.05), whereas the average Runx-2 expressions in the CHA-statin groups were significantly higher than in the other groups on days 1, 7, and 14 during the relapse phase (p < 0.05).

Conclusion

The nanoemulsion CHA-statin increased Runx-2 expression and decreased Acp 5 expression, thereby potentially preventing orthodontic relapse in rats.

{"title":"Effect of nanoemulsion carbonated hydroxyapatite-statin administration on Acp 5 and Runx-2 expression during orthodontic relapse in rats","authors":"Ananto Ali Alhasyimi , Niswati Fathmah Rosyida , Ika Dewi Ana","doi":"10.1016/j.jobcr.2024.12.013","DOIUrl":"10.1016/j.jobcr.2024.12.013","url":null,"abstract":"<div><h3>Background</h3><div>Retention is an essential element of orthodontic treatment. In the past two decades, numerous biological treatments have been developed to alleviate orthodontic relapse. Pharmacologic bone modulation is a viable approach to mitigate relapse. The aim of this investigation was to determine whether administering nanoemulsion carbonated hydroxyapatite-statin (CHA-statin) would increase Runx-2 expression and decrease Acp 5 expression in rats experiencing experimental orthodontic relapse.</div></div><div><h3>Materials & methods</h3><div>Forty-eight rats (n = 48) were assigned to four groups: control, CHA, statin, and CHA-statin, with 12 rats in each group. A 30 g mesial traction was applied for 7 days via a closed-coil spring that connected the first maxillary molar to the maxillary incisor. To maintain the moved teeth, CHA, statin hydrogel, and nanoemulsion CHA-statin were administered intrasulcularly every 3 days for a period of 7 days. The removal of the devices facilitated the occurrence of relapse. The expression of Acp 5 and Runx-2 was evaluated using the immunohistochemistry method. The collected data were evaluated using analysis of variance and post hoc tests, with <em>p</em> < 0.05.</div></div><div><h3>Results</h3><div>A significant reduction in Acp 5-positive cells in the CHA-statin group was observed on days 7 and 14 of relapse movement compared with the other groups (<em>p</em> < 0.05), whereas the average Runx-2 expressions in the CHA-statin groups were significantly higher than in the other groups on days 1, 7, and 14 during the relapse phase (<em>p</em> < 0.05).</div></div><div><h3>Conclusion</h3><div>The nanoemulsion CHA-statin increased Runx-2 expression and decreased Acp 5 expression, thereby potentially preventing orthodontic relapse in rats.</div></div>","PeriodicalId":16609,"journal":{"name":"Journal of oral biology and craniofacial research","volume":"15 1","pages":"Pages 129-135"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11758405/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143046559","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0